Hospital-based RNA Therapeutics

Tulsi Damase; Roman Sukhovershin; Min Zhang; Daniel Kiss; John Cooke

doi:10.20944/preprints202201.0073.v1

Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 22 December 2021 / Approved: 6 January 2022 / Online: 6 January 2022 (11:20:59 CET)

Hospital-based programs democratize mRNA therapeutics by facilitating the processes to translate a novel RNA idea from the bench to the clinic. Because mRNA is essentially biological software, therapeutic RNA constructs can be rapidly developed. The generation of small batches of clinical grade mRNA to support IND applications and first-in-man clinical trials, as well as personalized mRNA therapeutics delivered at the point-of-care, is feasible at a modest scale of cGMP manufacturing. Advances in mRNA manufacturing science and innovations in mRNA biology, are increasing the scope of mRNA clinical applications.

Messenger RNA • Hospital-based mRNA therapeutics • circular mRNA • self-amplifying mRNA • RNA-based CAR T-cell • RNA-based gene-editing tools

MEDICINE & PHARMACOLOGY, Other

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Hospital-based RNA Therapeutics

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