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Preprint ARTICLE | doi:10.20944/preprints202404.0635.v1

Endometrial Proliferative Phase-Centered View on the Transcriptome Dynamics Across the Menstrual Cycle

Apostol Apostolov, Mladen Naydenov, Aive Kalinina, Maria Nikolova, Merli Saare, Elina Aleksejeva, Nadezhda Milova, Antoan Milov, Andres Salumets, Vesselin Baev, Galina Yahubyan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: endometrial cycle; mid-proliferative phase; late-proliferative phase; early-secretory phase; mid-secretory phase; late-secretory; transcriptome profiles

Online: 9 April 2024 (11:42:51 CEST)

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The endometrium, the inner mucosal lining of the uterus, undergoes complex molecular and cellular changes across the menstrual cycle in preparation for embryo implantation. Transcrip-tome-wide analyses have mainly been utilized to study the endometrial receptivity, the prerequisite for successful implantation, with most of the studies, so far, comparing the endometrial transcriptomes between (i) secretory versus proliferative endometrium or (ii) mid-secretory versus early-secretory endometrium. In the current study, we provide the complete transcriptome description of the endometrium across the entire menstrual cycle and, for the first time, comprehensively characterize the proliferative phase of the endometrium. Our temporal transcriptome analysis includes five time points: mid-proliferative, late-proliferative (peri-ovulatory phase), early-secretory, mid-secretory, and late-secretory phases. Thus, we exhaustively unveil the transitions between the consecutive proliferative and secretory phases, highlighting their unique gene expression profiles and possible distinct biological functions. Transcriptome analysis reveals many differentially expressed genes (DEGs) across the menstrual cycle, most of which are phase-specific. As an example of the coordinated gene activity, the expression profile of his-tone-encoding genes within the HIST cluster on chromosome 6 showed an increase in cluster activity during the late-proliferative and a decline during the mid-secretory phase. Moreover, numerous DEGs are shared among all phases. In conclusion, in the current study, we delineate the endometrial proliferative phase-centered view of transcriptome dynamics across the menstrual cycle. Data analysis highlights significant transcriptomic and functional changes occurring during the late-proliferative phase – an essential transition point from the proliferative to the secretory phase. Future studies should explore how the biology of the late-proliferative phase endometrium impacts the achievement of mid-secretory endometrial receptivity or contributes to molecular aberrations leading to embryo implantation failure.

Preprint ARTICLE | doi:10.20944/preprints202003.0358.v1

Detailed Experiment-Theory Comparison of Mid-Infrared Metasurface Perfect Absorbers

Naoki To, Saulius Juodkazis, Yoshiaki Nishijima

Subject: Physical Sciences, Optics And Photonics Keywords: metasurface; mid infrared absorption; perfect absorption

Online: 27 March 2020 (12:32:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0264.v1

Secretory Leucoprotease Inhibitor (SLPI) Promotes Survival during Acute Pseudomonas aeruginosa Infection by Suppression of Inflammation Rather than Microbial Killing

Megan Osbourn, Aoife M. Rogers, Alice V. Dubois, Donna M. Small, Fiachra Humphries, Nezira Delagic, Paul N. Moynagh, Sinead Weldon, Clifford C. Taggart, Rebecca J. Ingram

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Secretory leucoprotease inhibitor; SLPI; inflammation; infection; Pseudomonas

Online: 19 October 2022 (03:59:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202401.2074.v1

Nanoparticle-Based Secretory Granules Induce a Specific and Long-Lasting Immune Response through Prolonged Antigen Release

Laia Bosch-Camós, Carlos Martínez-Torró, Hèctor López-Laguna, Jara Lascorz, Jordi Argilaguet, Antonio Villaverde, Fernando Rodríguez, Esther Vázquez

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Recombinant proteins; Biomaterials; protein nanoparticles; secretory granules; immunization

Online: 30 January 2024 (05:30:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0031.v1

In vitro Expression, Characterisation and Subcellular Localisation of AvrPi54 Protein, an Effector of Rice Blast Fungus Magnaporthe oryzae

Banita Kumari Saklani, Kirti Arora, Ravi Kumar Asthana, Tilak Raj Sharma

Subject: Biology And Life Sciences, Plant Sciences Keywords: avirulence; resistance; avrPi54; secretory protein; localization; particle bombardment

Online: 4 June 2019 (12:58:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0061.v1

A Satellite View of the Atmospheric Dry Intrusion and its Influences on the Mid-Latitude Disastrous Weather

Yi-xuan Shou, Feng Lu, Shaowen Shou

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: dry intrusion; Stratosphere-troposphere exchange; mid-latitude; satellite

Online: 18 September 2016 (10:27:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1932.v1

DNA damage response & senescence-associated secretory phenotype pathway: Emerging targets for anti-aging

Jawad Nadeem, Amna Parveen, Sun Yeou Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Anti-aging, DNA damage response, senescence-associated secretory phenotype

Online: 28 September 2023 (04:56:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1307.v1

Acute Kidney Injury, Renal Replacement Therapy, and Sepsis after Cardiac Surgery: The Roles of TIMP2*IGBP7 and Mid-Regional Pro-Adrenomedullin

Antonio Lacquaniti, Fabrizio Ceresa, Susanna Campo, Giovanna Barbera, Daniele Caruso, Elenia Palazzo, Francesco Patanè, Paolo Monardo

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney Injury; TIMP2xIGBP7; mid-regional-pro-adrenomedullin; sepsis

Online: 19 July 2023 (08:15:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0548.v1

Deterministic Model of the Eddy Dynamics for a Midlatitude Ocean Model

Takaya Uchida, Bruno Deremble, Stephane Popinet

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Mesoscale eddy closure; Quasi geostrophy; Mid-latitude double gyre

Online: 24 May 2021 (09:37:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1256.v1

TitleBiological Effects of “Inflammageing” on Human Oral Cells: Insights into a Potential Confounder of Age-Related Diseases

Elli Alexakou, Athina Bakopoulou, Danae A Apatzidou, Aristeidis Kritis, Andigoni Malousi, Vassiliki Anastassiadou

Subject: Biology And Life Sciences, Life Sciences Keywords: inflammageing; senescence; pro-inflammatory stimulus; Senescence Associated Secretory Phenotype (SASP)

Online: 20 November 2023 (16:15:05 CET)

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Objectives: The term "inflammageing” describes the process of inflammation-induced aging that leads living cells to a state of permanent cell cycle arrest due to chronic antigenic irritation. This in vitro study aimed to shed light on the mechanisms of “inflammageing” on human oral cells. Methods: Primary cultures of human gingival fibroblasts (hGFs) were exposed to variable pro-inflammatory stimuli, including lipopolysaccharide (LPS), Tumor Necrosis Factor-alpha (TNFa), and gingival crevicular fluid (GCF) collected from active periodontal pockets of systemically healthy patients. Inflammageing was studied through two experimental models, employing either late-passage (“aged”) cells (p.10) that were exposed to the pro-inflammatory stimuli or early-passage (“young”) cells (p.1) continuously exposed during a period of several passages (up to p.10) to the above-mentioned stimuli. Cells were evaluated for the expression of beta-galactosidase activity (histochemical staining), senescence-associated genes (qPCR analysis), and biomarkers related to a Senescence Associated Secretory Phenotype (SASP), through proteome profile analysis and bioinformatics. Results: A significant increase (p<0.05) of beta-galactosidase-positive cells was observed after exposure to each pro-inflammatory stimulus. The senescence-associated gene expression included upregulation for CCND1 and downregulation for SUSD6, and STAG1, a profile typical for cellular senescence. Overall, pro-inflammatory priming of late-passage cells caused more pronounced effects in terms of senescence, than long-term exposure of early-passage cells to these stimuli. Proteomic analysis showed induction of SASP, evidenced by upregulation of several pro-inflammatory proteins (IL-6, IL-10, IL-16, IP-10, MCP-1, MCP-2, M-CSF, MIP-1a, MIP-1b, TNFb, sTNF-RI, sTNF-RII, TIMP-2) implicated in cellular aging and immune responses. The least potent impact on the induction of SASP was provoked by LPS and the most pronounced by GCF. Conclusion: This study demonstrates that long-term exposure of hGFs to various pro-inflammatory signals induced or accelerated cellular senescence with the most pronounced impact noted for the late-passage cells. The outcome of this analyses provides insights into oral chronic inflammation, as a potential confounder of age-related diseases.

Preprint ARTICLE | doi:10.20944/preprints202310.1324.v1

Selection of the Most Informative Wavenumbers to Improve Prediction Accuracy of Milk Fatty Acid Profile Based on Milk Mid-Infrared Spectra Data

Wenqi Lou, Luiz Fernando Brito, Xiuxin Zhao, Jianbin Li, Yachun Wang

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: feature selection; milk mid-infrared spectra; fatty acids concentration; regression

Online: 20 October 2023 (10:15:41 CEST)

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Milk MIR spectra have been shown to provide valuable information on a wide range of traits to be used in dairy cattle breeding programs. Selecting the most informative variables from complex data can improve prediction accuracy and model robustness and, consequently, the interpretability of MIR spectra. Thus, we aimed to investigate the prediction performance of feature selection methods based on MIR spectra data, using the milk fatty acid (FA) profile as an example to illustrate the evaluated procedure. Data of MIR spectra, milk test-day records, and reference FA concentrations of 155 first-parity Holstein cows were used in the analyses. Four models comprising different explanatory variables and five feature selection methods were evaluated. The results indicated that the Competitive Adaptive Reweighted Sampling (CARS) method can effectively select the most informative variables from the MIR spectra, resulting in higher prediction accuracies than other variable selection approaches. The model including selected MIR spectra and cow information variables [days in milk at the test day, age at the test day, pregnancy stage (in days), number of days open, number of inseminations, and somatic cell count] yielded the best FA profile predictions based on Partial Least Square regression. In particular, ten FAs (C8:0, C10:0, C14:1, C17:0 isomers, C18:1, C18:1 isomer, medium-chain FA, unsaturation FA, monounsaturated FA, and polyunsaturated FA) presented accuracies based on the determination coefficient (R2cv) ranging from 0.66 to 0.85 in internal validation and from 0.65 to 0.84 in external validation. By running CARS 1,000 times in internal validations, we obtained the frequency of selected milk MIR wavenumber for 35 FAs. The most related wavenumbers to FAs were found within 1,003 to 1,145 cm-1, while other discrete areas were between 1,651 to 1,797 and 2,834 to 2,954 cm-1. These biomarkers may give insights into the relationship between MIR spectra and FA phenotypes. In conclusion, using CARS and cow information improved predictions of FAs based on MIR spectra in Chinese Holstein dairy cows. Additional validation studies should be conducted as larger datasets become available.

Preprint REVIEW | doi:10.20944/preprints202304.0295.v4

Treatments of COVID-19-Associated Taste and Saliva Secretory Disorders

Hironori Tsuchiya

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: COVID-19; taste disorder; saliva secretory disorder; treatment; pathogenic mechanism

Online: 14 April 2023 (03:34:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0229.v1

The Mid Miocene Climatic Optimum (MMCO) Indication at Low Latitude Sediment Case Study: The Miocene Cibulakan Formation, Bogor Basin

Wahyu Dwijo Santoso, Rubiyanto Kapid, Ben Ikhsan, Moehammad Ali Jambak, Dasapta Erwin Irawan

Subject: Environmental And Earth Sciences, Paleontology Keywords: Mid Miocene Climatic Optimum (MMCO); nannoplankton; temperature changes; Cibulakan Formation

Online: 24 January 2018 (18:50:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1072.v1

Geochemical Characteristics of Surface Sediments in the Xunmei Hydrothermal Field (26°S), Mid-Atlantic Ridge: Implications for Hydrothermal Activity

Peng Yang, Chuanshun Li, Yuan Dang, Lei Fan, Baoju Yang, Yili Guan, Qiukui Zhao, Dewen Du

Subject: Environmental And Earth Sciences, Oceanography Keywords: South Mid-Atlantic Ridge; metalliferous sediments; Xunmei Hydrothermal Field; geochemical characteristics

Online: 15 August 2023 (04:36:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0160.v2

NIH SenNet Consortium: Mapping Senescent Cells in the Human Body to Understand Health and Disease

Patty J Lee, Philip Blood, Katy Börner, Judith Campisi, Feng Chen, Heike Daldrup-Link, Phil De Jager, Li Ding, Francesca E. Duncan, Oliver Eickelberg, Rong Fan, Toren Finkel, Vesna Garovic, Nils Gehlenborg, Carolyn Glass, Ziv Bar-Joseph, Pragati Katiyar, So-Jin Kim, Melanie Königshoff, George Kuchel, Haesung Lee, Jun H. Lee, Jian Ma, Qin Ma, Simon Melov, Kay Metis, Ana L. Mora, Nicolas Musi, Nicola Neretti, João F. Passos, Irfan Rahman, Juan Carlos Rivera-Mulia, Paul Robson, Mauricio Rojas, Ananda L. Roy, Birgit Schilling, Pixu Shi, Jonathan Silverstein, Vidyani Suryadevera, Jichun Xie, Jinhua Wang, An-Kwok Ian Wong, Laura Niedernhofer

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Cellular Senescence Network; Normal Aging; Senescence; Senescence-associated secretory phenotype; SenNet

Online: 15 September 2022 (12:52:05 CEST)

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Working Paper COMMUNICATION

Mid-Low Resolution Remote Sensing Ship Detection Using Super-Resolved Feature Representation

Shitian He, Huanxin Zou, Yingqian Wang, Runlin Li, Fei Cheng, Xu Cao

Subject: Computer Science And Mathematics, Computer Vision And Graphics Keywords: Ship detection; image super-resolution; mid-low resolution remote sensing images

Online: 16 August 2021 (12:51:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0263.v1

Geometry of Chalcogenide Negative Curvature Fibers for CO₂ Laser Transmission

Chengli Wei, Curtis R. Menyuk, Jonathan Hu

Subject: Physical Sciences, Optics And Photonics Keywords: CO2 lasers; negative curvature fibers; chalcogenide glass; fiber loss; mid-IR

Online: 16 July 2018 (08:40:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0386.v1

Integrated Photonic Sensors with Enhanced Evanescent Field: Unveiling the Dynamic Interaction with the Ambient Medium

Muhammad A. Butt

Subject: Physical Sciences, Optics And Photonics Keywords: Evanescent field; photonic sensor; optical waveguide; light-matter interaction; absorption; mid-infrared.

Online: 6 February 2024 (15:36:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2172.v1

Compact diode pumped solid state laser with intracavity pump-enhanced DFG emitting at ~3.5 microns

Liam Gerrit Keith Flannigan, Ali Atwi, Tyler Kashak, Daniel Poitras, Chang-qing Xu

Subject: Physical Sciences, Optics And Photonics Keywords: nonlinear optics; difference frequency generation; mid-infrared laser; DPSS laser; linear cavity

Online: 2 October 2023 (11:20:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.2127.v1

Impact of Inflammation on the In Vivo Activity of the Renal Transporters OAT1/3 in Pregnant Women Diagnosed with Acute Pyelonephritis

Jhohann Richard de Lima Benzi, Patrícia Pereira dos Santos Melli, Geraldo Duarte, Jashvant D. Unadkat, Vera Lucia Lanchote

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Inflammation; Pharmacokinetics; OAT1; OAT3; Pregnancy; Pyelonephritis; Furosemide; Furosemide glucuronide; Renal secretory clearance

Online: 31 August 2023 (12:38:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1335.v1

Improved Posttransplant Outcomes with HTK-Custodial When Compared to St. Thomas Solution for Preservation of the Cardiac Allograft

Filip Dulguerov, Tamila Abdurashidova, Emeline Christophel-Plathier¹, Barbara Pitta-Gros, Anna Nowacka, Ziyad Gunga, Raymond Pfister, Mario Verdugo-Marchese, Valentina Rancati, Lars Niclauss, Piergiorgio Tozzi, Albert Adelin, Zied Ltaief, Samuel Rotman, Philippe Meyer, Roger Hullin, Matthias Kirsch

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Heart Transplantation; Cardiac Preservation Solutions; Inotropic Score; Early Results; Mid-term Results

Online: 18 May 2023 (10:50:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0423.v1

Is “Cellular Senescence” a Misnomer?

David Gems, Carina Kern

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Aging; cellular senescence; fibroblast; osteoarthritis; remodeling-associated secretory phenotype (RASP); remodeling activation

Online: 27 July 2022 (13:38:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0287.v1

Benzaldehyde Attenuates the Fifth Stage Larval Excretory-Secretory Product of Angiostrongylus cantonensis-Induced Injury in Mouse Astrocytes via Regulation of Endoplasmic Reticulum Stress and Oxidative Stress

Kuang-Yao Chen, Yi-Ju Chen, Chien-Ju Cheng, Kai-Yuan Jhan, and Lian-Chen Wang

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Excretory-secretory products; Angiostrongylus cantonensis; Astrocytes; Benzaldehydes; endoplasmic reticulum stress; oxidative stress

Online: 16 November 2021 (11:34:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0546.v1

Comparative Modeling of Infrared Fiber Lasers

Slawomir Sujecki, Lukasz Sojka, Trevor Benson, Angela Seddon, Emma Barney, Mario Faconi, Francesco Prudenzano, Marian Marciniak, Hovik Baghdasaryan, Pavel Peterka, Stefano Taccheo

Subject: Engineering, Electrical And Electronic Engineering Keywords: mid-infrared light sources; near-infrared light sources; rare earth-doped fibers

Online: 23 October 2018 (16:32:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0012.v1

Evaluation of Thiol-dependent Enzymes on the Pharmacological Effects Induced by the Catalytically Active PLA2 from Bothrops jararacussu

Marcos Hikari Toyama, Caroline R. C. Costa, Mariana Novo Belchor, Adeilso Bispo dos Santos Junior, Laila Lucyane Ferreira de Moraes, Airam Roggero dos Santos Silva, Marcos Antonio de Oliveira

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Secretory Phospholipase A2, Bothrops jararacussu, Oxidative Stress, Edema, Myonecrosis and Thiol Dependent Antioxidant

Online: 3 May 2021 (16:15:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0702.v1

An Integrated Analytical Approach Reveals Trichome Acylsugar Metabolite Diversity in the Wild Tomato Solanum Pennellii

Daniel B. Lybrand, Thilani M. Anthony, Arthur Daniel Jones, Robert L. Last

Subject: Biology And Life Sciences, Plant Sciences Keywords: acylsugar; wild tomato; Solanum pennellii; secretory glandular trichome; specialized metabolism; intraspecific variation; metabolomics

Online: 31 August 2020 (05:15:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0498.v1

Harnessing Nasal Immunity with Iga to Prevent Respiratory Infections

John Joseph

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Secretory IgA; IgA class switching; SARS-CoV-2; respiratory pathogens; nasal vaccines; vaccine adjuvants

Online: 30 August 2022 (02:33:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0354.v1

Risk Factors Contributing to the Progression of Paroxysmal and Persistent Atrial Fibrillation in Heart Failure Patients with Mid-Range Ejection Fraction

Lusine Hazarapetyan, Lyudmila Budaghyan, Alina Maloyan, Svetlana Grigoryan

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart failure; mid-range ejection fraction; atrial fibrillation; cardiac inflammation; cardiac fibrosis; risk factors.

Online: 15 July 2021 (10:18:01 CEST)

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Aims: Heart failure (HF) is frequently accompanied by atrial fibrillation (AF), a combination that worsens the outcomes of both diseases. Despite advances in the treatment of AF, it remains a serious and unsolved problem for clinicians and researchers. The aim of this study was to examine risk factors for incidents of paroxysmal and persistent AF in patients having heart failure with mid-range ejection fraction (HFmrEF). Methods. Overall, 71 patients with HFmrEF and non-valvular AF, including paroxysmal and persistent types, were enrolled in this study. As a control group, 42 HFmrEF patients without AF were also enrolled. All patients underwent detailed physical examination, including resting electrocardiography, echocardiography, and 24-hour ambulatory Holter monitoring. Levels of the inflammation markers high-sensitivity C-reactive protein (hs-CRP), interleukin-6 (IL-6), and tumor necrosis factor α (TNF-α) and the fibrotic marker transforming growth factor-β1 (TGF-β1) were measured by ELISA and expressed as odds ratios. Results: We show that paroxysmal AF was associated with higher diastolic blood pressure, whereas both paroxysmal and persistent forms of AF were associated with more frequent occurrence of hypertensive crisis episodes and greater body mass index. Progression from paroxysmal to persistent AF was associated with significant ventricular remodeling. Persistent and paroxysmal AF were associated with higher levels of inflammatory markers when compared to HFmrEF patients having no AF. In addition, TGF-1 was significantly increased in HFmrEF patients having persistent but not paroxysmal AF. Conclusions: Occurrence of AF, first paroxysmal and then persistent, in HFmrEF patients is associated with left ventricular remodeling and the appearance of systemic inflammatory and fibrotic markers. Changes in those parameters may be indicators by which to identify patients at increased risk of atrial fibrillation. Further studies are needed to determine the prognostic validity of these markers.

Preprint CONCEPT PAPER | doi:10.20944/preprints201804.0358.v1

Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite

Tommaso C. Bulfone, Stephen P. Samuel, Philip L. Bickler, Matthew R. Lewin

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: snakebite; antidote; inhibitor; small molecule therapeutics; SMT; secretory phospholipase; sPLA2; Neglected Tropical Disease; NTD

Online: 27 April 2018 (09:00:55 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201803.0211.v1

ERBB1 and ERBB2 Positive Medullary Thyroid Carcinoma: A Case Report

Michele Minuto, Emanuela Varaldo, Gianluca Marcocci, Amleto de Santanna, Ermanno Ciccone, Katia Cortese

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MTC; calcitonin; parafollicular C cells; secretory granules; immunofluorescence; ultrastructure; transmission electron microscopy; ERBB1; ERBB2

Online: 26 March 2018 (09:05:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0498.v2

On the Quantum Nature of a Fireball Created in Ultrarelativistic Nuclear Collisions

Valeriy Kizka

Subject: Physical Sciences, Nuclear And High Energy Physics Keywords: Hadronic matter; Quark-Gluon Plasma; heavy-ion collisions; hyperon production; mid-rapidity multiplicity; nuclear spin

Online: 7 October 2022 (15:06:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0124.v1

Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-directed Therapies.

Robert E. E. Brown, Robert L Hunter

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tuberculosis; secretory antigens; bronchiolar epithelium; alveolar pneumocytes; M2 polarization; COX-2, FAS; Pathogenesis; early lesion

Online: 5 November 2021 (14:50:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0404.v2

Early Lesion of Post-Primary Tuberculosis: Subclinical Driver of Disease and Target for Vaccines and Host-directed Therapies

Robert E. E. Brown, Robert L Hunter

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tuberculosis; secretory antigens; bronchiolar epithelium; alveolar pneumocytes; M2 polarization; COX-2, FAS; Pathogenesis; early lesion

Online: 29 September 2021 (09:56:22 CEST)

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Preprint DATA DESCRIPTOR | doi:10.20944/preprints202108.0153.v1

Passive Biaxial Tensile Dataset of Three Main Rat Heart Myocardia: Left Ventricle, Mid-Wall and Right Ventricle

Fulufhelo Nemavhola, Harry Ngwangwa, Neil Davies, Thoams Franz

Subject: Engineering, Mechanical Engineering Keywords: Cardiac mechanics; Biaxial testing; Rat heart; Left ventricle mechanics; Mid-wall mechanics; Right ventricle mechanics

Online: 6 August 2021 (08:24:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0631.v1

On the Relationship between Circulation Patterns, the Southern Annular Mode, and Rainfall Variability in Western Cape

Chibuike Chiedozie Ibebuchi

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Western Cape; Southern Annular Mode; Circulation type; Africa south of the equator; mid-latitude cyclone

Online: 26 May 2021 (11:04:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0433.v1

Mid-Miocene Formation of the Yangtze River-Lake System Revealed by Ancestral Spawning Reconstruction of Endemic Cyprinids

Yeke Wang, Feng Chen, Jun He, Liang Chen, Ge Xue, Yan Zhao, Yanghui Peng, Jun Chen, Ping Xie

Subject: Environmental And Earth Sciences, Atmospheric Science And Meteorology Keywords: Formation of the Yangtze river-lake system, Mid-Miocene, ancestral egg-type reconstruction, endemic cyprinids

Online: 22 January 2021 (08:41:48 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0144.v1

Intravenous Immunoglobulin for Treating Bacterial Infections: One More Mechanism of Action

Teiji Sawa, Mao Kinoshita, Keita Inoue, Junya Ohara, Kiyoshi Moriyama

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: immunoglobulin; IVIG; LcrV; PcrV; translocation; type III secretory toxin; type III secretion system; V-antigen

Online: 14 September 2019 (19:18:28 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201810.0339.v1

Better Resolution of High-Spin Cobalt Hyperfine at Low Frequency: Co-Doped Ba(Zn_1/3Ta_2/3)O₃ as a Model Complex

William E. Antholine, Shengke Zhang, Justin Gonzales, Nathan Newman

Subject: Physical Sciences, Chemical Physics Keywords: electron paramagnetic resonance; EPR; multi-frequency EPR; high-spin cobalt complex; resolution of A-mid

Online: 16 October 2018 (08:04:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0420.v1

Hydrolytic Enzymes, Proteases, Permeases, and Transporters as Cryptococcus neoformans Weapons in Human Infections

Olufemi Samuel Folorunso, Olihile Moses Sebolai

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Cryptococcus; extracellular protease; biofilm, secretory vesicles; hypoxia; hydrolytic enzyme; homeostasis; transcription factors; membrane permeases; membrane transporters

Online: 24 January 2023 (03:08:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0022.v1

T Lymphocyte-Derived Exosomes and Their Applications in Cancer Therapy

Victor Calvo, Manuel Izquierdo

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: exosomes; T lymphocytes; immune synapse; secretory granules; multivesicular bodies; cytotoxic activity; cell death; CAR T lymphocytes

Online: 1 February 2022 (21:33:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0261.v1

Towards Real-Time In-Situ Mid-Infrared Spectroscopic Ellipsometry in Polymer Processing

Alexander Ebner, Robert Zimmerleiter, Kurt Hingerl, Markus Brandstetter

Subject: Chemistry And Materials Science, Polymers And Plastics Keywords: ellipsometry; quantum cascade laser; in-line monitoring; polymer films; polymer processing; real-time; mid-infrared spectroscopy

Online: 15 November 2021 (13:07:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0884.v2

Physical and Technological Aspects of Laser Induced Damage of ZGP Single Crystals under Periodically-Pulsed Laser Irradiation at 2.1 μm

Nikolay Yudin N. Yudin, Victor Dyomin, Alexander Gribenyukov, Oleg Antipov, Andrei Khudoley, Igor O. Kinyaevskiy, Mikhail Zinovev, Sergey Podzyvalov, Vladimir Kuznetsov, Elena Slyunko, Alexey Lysenko, Andrey Kalsin, Ilya Eranov, Houssain Baalbaki

Subject: Physical Sciences, Optics And Photonics Keywords: ZGP; single crystal; laser induced damage threshold; mid-IR optical parametric oscillators and generators; Ho3+:YAG lasers

Online: 23 November 2023 (04:52:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202110.0447.v1

The Unfolded Protein Response as Guardian of the Secretory Pathway

Toni Radanović, Robert Ernst

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: UPR; IRE1; PERK; ATF6; lipid bilayer stress; ER stress; secretory pathway; hydrophobic mismatch; membrane thickness; membrane stiffness

Online: 29 October 2021 (07:57:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0397.v1

Broadband Time-Resolved Absorption and Dispersion Spectroscopy of Methane and Ethane in A Plasma Using a Mid-Infrared Dual-Comb Spectrometer

Muhammad Ali Abbas, Luuk van Dijk, Khalil Eslami Jahromi, Mohammadreza Nematollahi, Frans J.M. Harren, Amir Khodabakhsh

Subject: Physical Sciences, Atomic And Molecular Physics Keywords: dual frequency comb spectroscopy; mid-infrared absorption and dispersion spectroscopy; electrical discharge plasma; time-resolved plasma kinetics

Online: 17 September 2020 (11:03:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0577.v1

Global Evidence of Obliquity Damping in Climate Proxies and Sea-Level Record during the Last 1.2 Ma: A Missing Link for the Mid-Pleistocene Transition

Paolo Viaggi

Subject: Environmental And Earth Sciences, Geophysics And Geology Keywords: mid-pleistocene transition; obliquity–oblateness feedback; obliquity damping hypothesis; water- mass redistribution; glacio-eustatic sea level; short eccentricity

Online: 8 September 2023 (13:07:04 CEST)

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A recent research has identified an inverse amplitude link between obliquity damping and short eccentricity amplification during Mid-Late Pleistocene based on LR04 δ18O and equatorial Pacific Site 846 sea surface temperature records, which is associated with the Earth's long-term cooling. In the present study, new evidence of this anticorrelation is presented from Antarctic D-CO2-CH4 records, global benthic-planktic δ18O, and regional (Atlantic, Pacific, Mediterranean, and Indian) climate-related proxies. Based on a critical review of theoretical constrains (Earth's oblateness changes and ice-volume phase lag in the obliquity band <5.0 kyr), this widespread and symmetric (bipolar) obliquity response damping has been interpreted as an effect of the obliquity-oblateness feedback, which could be the latent physical mechanism at the origin of the Mid-Pleistocene Transition (MPT). Indeed, results and considerations of the present work suggest that fast and positive/negative net variation of the Earth's oblateness in the obliquity band was controlled by dominant glacio-eustatic water mass component and, assuming a rapid response of the ice-volume to surface temperature changes, the mean obliquity lag response is estimated to be <5.0 kyr over the past 800 kyr. These elements may explain the interglacial/glacial damping observed in the obliquity response. The consolidation of the Earth's long-term icy-state in the subtrend IV, culminated with the post-MPT obliquity damping, might have contributed to the strengthening of the short eccentricity response by mitigating the obliquity ‘ice-killing’ during obliquity maxima (interglacials), favouring the obliquity-cycle skipping and a feedback amplified ice-growth in the short eccentricity band (obliquity damping hypothesis). This could suggest a different impact of the climate friction than what is generally believed, which is presumably the latent physical mechanism that triggers transient ‘competitive’ interaction between obliquity and short eccentricity started early during the Piacenzian.

Preprint ARTICLE | doi:10.20944/preprints202308.1198.v1

Numerical Analysis of the Axial-Flexural Behavior of CFST Columns with Active Transverse Prestressing

Xiao Hu, Albert Albareda, Xiangbo Bu, Francesc López-Almansa

Subject: Engineering, Civil Engineering Keywords: seismic behavior; mid-rise framed buildings; composite building columns; concrete-filled steel tubes; confinement effect; active hoop prestress

Online: 16 August 2023 (11:08:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0733.v1

Protein-Bound Uremic Toxins in Senescence and Kidney Fibrosis

Yi Yang, Milos Mihajlovic, Rosalinde Masereeuw

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: chronic kidney disease; uremic toxins; renal tubular transport; extracellular matrix remodeling; apoptosis resistance; inflammatory response; senescence-associated secretory phenotype factors

Online: 9 August 2023 (10:49:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints201908.0186.v1

Roles of Extracellular Vesicles (EVs) Carrying HSPs in Cancer Biomarkers, Immune Surveillance, and Immune Evasion

Eman Taha, Kisho Ono, Takanori Eguchi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy

Online: 17 August 2019 (16:15:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0468.v1

Fluid inclusion studies of barite disseminated in hydrothermal sediments of the Mohns Ridge

Marina D. Kravchishina, Vsevolod Yu. Prokofief, Olga M. Dara, Boris V. Baranov, Alexey A. Klyuvitkin, Karina S. Iakimova, Vladislav Yu. Kalgin, Alla Yu. Lein

Subject: Environmental And Earth Sciences, Geochemistry And Petrology Keywords: barite; fluid inclusion; hydrothermal vent field; hydrothermal fluid; mineralization; volcanogenic massive sulfide deposits; ultraslow-spreading ridge; Mohns Ridge; Arctic Mid-Ocean Ridge.

Online: 7 July 2023 (10:09:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0299.v1

MSSI-based Dispersion-managed Link Configured by Randomly-distributed RDPS Only in Former Half Section

Jae-Pil Chung, Seong-Real Lee

Subject: Physical Sciences, Optics And Photonics Keywords: dispersion management; mid-span spectral inversion; dispersion map; optical phase conjugator; residual dispersion per span; random distribution; chromatic dispersion; nonlinear Kerr effect; wavelength division multiplexed

Online: 17 August 2022 (04:17:45 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0386.v1

Exosome Release of Drugs: Coupling with Epithelial-Mesenchymal Transition

Takanori Eguchi, Kisho Ono, Stuart Calderwood, Kuniaki Okamoto

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology

Online: 29 December 2019 (13:46:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0102.v1

Effectiveness of Acute Malnutrition Treatment at Health Center and Community Level with a Simplified, Combined Protocol in Mali: An Observational Cohort Study

Suvi T. Kangas, Bethany Marron, Zachary Tausanovitch, Elizabeth Radin, Josiane Andrianarisoa, Salimou Dembele, Issa Niamanto Coulibaly, Cesaire Ouedraogo, Marie Biotteau, Bareye Ouologuem, Soumaila Daou, Fatoumata Traore, Issiaka Traore, Marc Nene, Jeanette Bailey

Subject: Medicine And Pharmacology, Dietetics And Nutrition Keywords: acute malnutrition; combined protocol; community-based management of acute malnutrition; ef-fectiveness; Mali; mid-upper-arm circumference; moderate acute malnutrition; ready-to-use ther-apeutic food; treatment; severe acute malnutrition; simplified protocol; wasting

Online: 7 September 2022 (05:21:16 CEST)

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