Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite

Tommaso C. Bulfone; Stephen P. Samuel; Philip L. Bickler; Matthew R. Lewin

doi:10.20944/preprints201804.0358.v1

Preprint Concept Paper Version 1 Preserved in Portico This version is not peer-reviewed

Version 1 : Received: 26 April 2018 / Approved: 27 April 2018 / Online: 27 April 2018 (09:00:55 CEST)

The World Health Organization (WHO) recently added snakebite envenoming to the priority list of Neglected Tropical Diseases (NTD). It is thought that ~75% of mortality following snakebite occurs outside the hospital setting, making the temporal gap between a bite and antivenom administration a major therapeutic challenge. Small molecule therapeutics (SMTs) have been proposed as potential pre-referral treatments for snakebite to help address this gap. Herein, we discuss the characteristics, potential uses and development of SMTs as potential treatments for snakebite envenomation. We focus on SMTs that are secretory phospholipase A2 (sPLA2) inhibitors and metalloprotease (MP) inhibitors.

snakebite; antidote; inhibitor; small molecule therapeutics; SMT; secretory phospholipase; sPLA2; Neglected Tropical Disease; NTD

Medicine and Pharmacology, Pharmacology and Toxicology

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Small Molecule Therapeutics for the Initial and Adjunctive Treatment of Snakebite

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