Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Harnessing Nasal Immunity with Iga to Prevent Respiratory Infections

Version 1 : Received: 29 August 2022 / Approved: 30 August 2022 / Online: 30 August 2022 (02:33:19 CEST)

A peer-reviewed article of this Preprint also exists.

Joseph, J. Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections. Immuno 2022, 2, 571-583. Joseph, J. Harnessing Nasal Immunity with IgA to Prevent Respiratory Infections. Immuno 2022, 2, 571-583.


Nasal cavity is a primary checkpoint for the invasion of several respiratory pathogens. Numerous pathogens including SARS-CoV-2, S. pneumonia, S. aureus, etc., adhere to the nasal epithelium or mucus to invade and trigger an infection. IgA serves as the first line of defense against foreign antigens and pathogens. They exhibit cross-reactivity against a diverse variety of antigens through immune exclusion, which intercepts the invasion of pathogens through the mucosal lining. Advances in intranasal immunization technology underscore the elevated neutralizing IgA levels at local and distal mucosa in contrast to the parenteral vaccines. This review highlights the adjuvants that induce IgA class switching and the challenges of maintaining nominal IgA levels at the mucosal surface. Finally, the review features the paradigm-shifting of conventional immunization techniques to IgA-inducing vaccines to enhance protection against homologous and heterologous pathogens.


Secretory IgA; IgA class switching; SARS-CoV-2; respiratory pathogens;nasal vaccines; vaccine adjuvants


Biology and Life Sciences, Immunology and Microbiology

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