SHORT NOTE
|
doi:10.20944/preprints202312.0899.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
monoamine oxidase; inhibitors; 1,3-oxazole; benzenesulfonamide; drug research; Parkinson’s disease; MAO
Online: 12 December 2023 (14:22:48 CET)
REVIEW
|
doi:10.20944/preprints202310.1318.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
advanced melanoma; immunotherapy; target therapy; lysine histone methyl transferase inhibitors; UNC0642
Online: 20 October 2023 (08:35:45 CEST)
REVIEW
|
doi:10.20944/preprints202305.0751.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
Skin pigmentation; melanin; Tyrosinase inhibitors; hypopigmentation; hyperpigmentation; Vitiligo; skin-lightening; Depigmentation
Online: 10 May 2023 (11:32:48 CEST)
REVIEW
|
doi:10.20944/preprints202201.0468.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Flavivirus; NS2B-NS3; ZIKA Virus; Dengue Virus; West Nile Virus; Inhibitors
Online: 31 January 2022 (13:46:44 CET)
ARTICLE
|
doi:10.20944/preprints202106.0565.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
HIV-1 transcription; HIV-1 Tat; TAR RNA; small molecule inhibitors
Online: 23 June 2021 (11:04:21 CEST)
REVIEW
|
doi:10.20944/preprints202102.0150.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
CTLA-4; Treg cells: Immune checkpoint inhibitors; CD28; Antigen Presenting Cells
Online: 5 February 2021 (09:35:47 CET)
REVIEW
|
doi:10.20944/preprints202311.1632.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
checkpoint inhibitors; esophageal cancer; gastric cancer; immunotherapy; PD-L1; HER2; clinical trials; history; disparities
Online: 28 November 2023 (01:45:08 CET)
ARTICLE
|
doi:10.20944/preprints202211.0516.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antivirals; coronavirus; COVID-19; covalent drugs; dynamic light scattering; inhibitors; main protease; natural products
Online: 28 November 2022 (13:40:01 CET)
REVIEW
|
doi:10.20944/preprints202403.0061.v1
Subject:
Medicine And Pharmacology,
Clinical Medicine
Keywords:
Atrial Fibrillation; Heart Failure with Preserved Ejection Fraction (HFpEF); Cardiac Amyloidosis; Molecular Imaging; Catheter Ablation; SGLT2 Inhibitors
Online: 1 March 2024 (14:46:58 CET)
ARTICLE
|
doi:10.20944/preprints202212.0206.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Cell-to-cell fusion; proprotein convertases; metalloproteases; mutagenesis; PCSK9; protease inhibitors; SARS-CoV-2; shedding; SKI-1/S1P; SREBP-2.
Online: 12 December 2022 (14:20:01 CET)
ARTICLE
|
doi:10.20944/preprints202103.0752.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Mixture toxicity; Neurotoxicity; Antagonism; Organophosphate; Acetylcholinesterase inhibitors; GABA; Behavior; Risk assessment; Spontaneous movement activity
Online: 31 March 2021 (07:52:05 CEST)
REVIEW
|
doi:10.20944/preprints202405.1755.v1
Subject:
Transplantation,
Medicine And Pharmacology
Keywords:
Keywords. Sodium-glucose- cotransporters type 2 inhibitors, glucose reabsorption, sodium reabsorption, randomized clinical trials, diabetes, heart failure, chronic kidney disease, kidney transplantati
Online: 27 May 2024 (14:31:30 CEST)
ARTICLE
|
doi:10.20944/preprints202403.1433.v1
Subject:
Computer Science And Mathematics,
Artificial Intelligence And Machine Learning
Keywords:
FLT3 Inhibitors; Ligand-based Drug Design; Computer-Aided Drug Design; QSAR Modeling; AML Treatment
Online: 25 March 2024 (08:47:40 CET)
ARTICLE
|
doi:10.20944/preprints202403.1686.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
lung adenocarcinoma; drug-tolerant persister (DTP) cells; intrinsic resistance; tyrosine kinase inhibitors (TKIs); erlotinib; osimertinib; senescent cells; CD74
Online: 28 March 2024 (12:16:57 CET)
REVIEW
|
doi:10.20944/preprints202108.0372.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; non-small cell lung carcinoma; PD-1; PD-L1; immune PET; immunotherapy; Radiomics; PET/CT
Online: 18 August 2021 (08:20:43 CEST)
ARTICLE
|
doi:10.20944/preprints202406.0034.v1
Subject:
Neuroscience And Neurology,
Biology And Life Sciences
Keywords:
voltage-gated sodium channels; fibroblast growth factors; split luciferase assay; kinase inhibitors
Online: 3 June 2024 (08:07:35 CEST)
ARTICLE
|
doi:10.20944/preprints202404.0043.v1
Subject:
Obstetrics And Gynaecology,
Medicine And Pharmacology
Keywords:
KELIM score; Homologous recombination deficiency (HRD); Poly (ADP-ribose) polymerase inhibitors (PARPi).
Online: 1 April 2024 (11:12:26 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202309.0196.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Neurodegenerative disorders; schizophremia; PDK1 inhibitors; Lipid replacement therapy; Aryl hydrocarbon receptor antagonists
Online: 4 September 2023 (14:29:13 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0458.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
polyamine analogs; monoamine oxidases; antiproliferative activity; inhibitors; docking studies; LN-229 cells
Online: 7 August 2023 (11:57:36 CEST)
REVIEW
|
doi:10.20944/preprints202308.0055.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
COVID-19; SARS-CoV-2 Mpro; protease inhibitors; coronavirus; peptidomimetics; Paxlovid; Nirmatrelvir
Online: 2 August 2023 (05:25:21 CEST)
ARTICLE
|
doi:10.20944/preprints202304.0530.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Poly (ADP-Ribose) Polymerase-1; PARP inhibitors; neoplasm; cancer; animal disease models
Online: 19 April 2023 (03:30:59 CEST)
ARTICLE
|
doi:10.20944/preprints202212.0170.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
SonoCloud; GL261 mouse model; ultrasound-mediated drug delivery; glioblastoma; immune checkpoint inhibitors
Online: 9 December 2022 (02:59:28 CET)
REVIEW
|
doi:10.20944/preprints202305.1239.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Hodgkin lymphoma; non-Hodgkin lymphoma; PD1 / PD-L1 checkpoint inhibitors; tumor mutational burden; predictive biomarkers
Online: 17 May 2023 (10:52:16 CEST)
ARTICLE
|
doi:10.20944/preprints202405.0084.v1
Subject:
Virology,
Biology And Life Sciences
Keywords:
natural extracts; chitosan; liposomes; encapsulation; drug release; coronavirus HCoV-0C43; antiviral activity; natural inhibitors of viral replication; cytotoxicity; phototoxicity
Online: 2 May 2024 (12:03:47 CEST)
REVIEW
|
doi:10.20944/preprints202207.0256.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
cancer; immunotherapy; adverse events; immune checkpoints inhibitors; chimeric antigen receptor therapy; bispecific antibodies; toxicity; renal; oncology
Online: 18 July 2022 (09:21:56 CEST)
REVIEW
|
doi:10.20944/preprints202012.0441.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
dystrohinopathy; Duchenne muscular disease; Becker muscular disease; dystrophic deficient cardiomyopathy; cardiac fibrosis; renin angiotensin system; angiotensin 2; angiotensin converter enzyme inhibitors; angiotensin receptor blockers; heart failure
Online: 18 December 2020 (07:18:16 CET)
COMMUNICATION
|
doi:10.20944/preprints202305.1298.v1
Subject:
Biology And Life Sciences,
Life Sciences
Keywords:
Mass spectrometry; RAS; ACE; ACE2; CPN; bradykinin; hypertension; cardiovascular disease; antihypertensiva; ACE inhibitors; angiotensin receptor blockers; bradykinin; neuropeptide re-porter assay
Online: 18 May 2023 (08:13:10 CEST)
SHORT NOTE
|
doi:10.20944/preprints202212.0230.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
monoamine oxidase; inhibitors; indole; 1,2,4-oxadiazole; drug research; neuroprotective drugs; Parkinson’s disease; MAO
Online: 13 December 2022 (07:12:01 CET)
ARTICLE
|
doi:10.20944/preprints201811.0330.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
hyperpigmentation; tyrosinase inhibitors; 3-(2,4-dihydroxyphenyl)propionic acid; structure-activity relationship study; B16-F10 cellular melanogenesis inhibition
Online: 14 November 2018 (09:59:45 CET)
ARTICLE
|
doi:10.20944/preprints202401.0661.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
Protozoan diseases; Drug repurposing; Cytotoxicity; Dihydrofolate reductase inhibitors; Potassium (K+) channel blocker; ADME properties
Online: 9 January 2024 (10:30:36 CET)
REVIEW
|
doi:10.20944/preprints202308.0688.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Urothelial cell cancer; metastasis, drug resistance, immunotherapy; immune checkpoint inhibitors; tumorigenesis; antibody–drug conjugate.
Online: 9 August 2023 (08:23:29 CEST)
HYPOTHESIS
|
doi:10.20944/preprints202305.1129.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
Lymphangiontrope; salt sensitivity; cardiorenal syndrome; SGLT2 inhibitors; Down’s syndrome; depression; schizophrenia; C Reactive Protein
Online: 16 May 2023 (08:51:13 CEST)
ARTICLE
|
doi:10.20944/preprints201801.0196.v1
Subject:
Medicine And Pharmacology,
Urology And Nephrology
Keywords:
comorbid diseases; erectile dysfunction; penile duplex doppler ultrasound; penile pathology; phosphodiesterase type 5 inhibitors
Online: 22 January 2018 (09:03:17 CET)
ARTICLE
|
doi:10.20944/preprints201908.0223.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
LSD1; molecular inhibitors; thieno[3,2-b]pyrrole-5-carboxamide derivatives; Molecular docking; 3D-QSAR; Molecular dynamics simulations
Online: 21 August 2019 (09:54:43 CEST)
REVIEW
|
doi:10.20944/preprints201807.0116.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
chemical space; chemoinformatics; data mining; databases; DNMT inhibitors; drug discovery; epi-informatics; molecular modeling; similarity searching; virtual screening
Online: 6 July 2018 (10:04:44 CEST)
REVIEW
|
doi:10.20944/preprints202405.0573.v1
Subject:
Gastroenterology And Hepatology,
Medicine And Pharmacology
Keywords:
Proton Pump Inhibitors (PPIs); Vonoprazan (VPZ); Intravenous infusion; Oral therapy; Bleeding peptic ulcers; Endoscopic therapy
Online: 9 May 2024 (09:15:54 CEST)
REVIEW
|
doi:10.20944/preprints202111.0317.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Non-Hodgkin lymphoma; Epigenetics; DNA methylation; HAT; HDAC; EZH2; bromodomain inhibitors; Drug combination; clinical testing
Online: 17 November 2021 (23:45:00 CET)
REVIEW
|
doi:10.20944/preprints201803.0227.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Antivenom; snakebite; small molecule toxin inhibitors; oligonucleotides; antibodies; phage display; next generation antivenom; recombinant antivenom
Online: 27 March 2018 (13:41:46 CEST)
REVIEW
|
doi:10.20944/preprints202306.1853.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
interleukin-1 beta (IL-1β); immune-checkpoint inhibitors (ICIs); non-small cell lung cancer (NSCLC); programmed death ligand 1 (PD-L1); therapeutic resistance
Online: 27 June 2023 (07:16:09 CEST)
ARTICLE
|
doi:10.20944/preprints202110.0145.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; PD-1; PD-L1; CTLA-4; immunotherapy; target therapy; BRAF; MET; melanoma; [18F]FDG PET/CT
Online: 8 October 2021 (14:14:14 CEST)
REVIEW
|
doi:10.20944/preprints202307.1242.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Immune checkpoint inhibitors (ICIs); Non–small cell lung cancer (NSCLC); PD-1 , PD-L1; CTLA-4
Online: 19 July 2023 (02:48:47 CEST)
ARTICLE
|
doi:10.20944/preprints202109.0429.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
hepatocellular carcinoma; hepatic arterial infusion chemotherapy; cisplatin; sorafenib; multikinase inhibitors; risk factors; propensity score-matched analysis
Online: 24 September 2021 (12:38:25 CEST)
CASE REPORT
|
doi:10.20944/preprints202005.0220.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
checkpoint inhibitors; tuberculosis; non-small cell lung cancer (NSCLC); Anti-PD-1; toxicity management; immunotherapy; pembrolizumab
Online: 13 May 2020 (04:38:50 CEST)
REVIEW
|
doi:10.20944/preprints201806.0056.v1
Subject:
Medicine And Pharmacology,
Pathology And Pathobiology
Keywords:
mTOR; mTORC1; mTORC2; rapamycin; rapalogues; rapalogs; mTOR inhibitors; senescence; ageing; aging; cancer; neurodegeneration; immunosenescence; senolytics; biomarkers
Online: 5 June 2018 (09:49:19 CEST)
REVIEW
|
doi:10.20944/preprints202309.0860.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
gastrointestinal cancer; immunotherapy; cancer vaccines; dendritic cell vaccine; adoptive cell treatment; cytokine-induced killer cells; immune checkpoint inhibitors; angiogenesis inhibition
Online: 13 September 2023 (10:07:21 CEST)
ARTICLE
|
doi:10.20944/preprints201804.0079.v1
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
Alzheimer’s disease (AD); amyloid precursor protein (APP); familial AD (FAD); sporadic AD (SAD); BACE1 inhibitors; APP-independent generation of beta amyloid
Online: 6 April 2018 (15:16:08 CEST)
ARTICLE
|
doi:10.20944/preprints202308.0332.v2
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
homologous recombination deficiency (HRD); biomarkers; ovarian cancer; DNA repair; BRCA1/2; poly (ADP–ribose) polymerase inhibitors (PARPi); next generation sequencing (NGS)
Online: 6 September 2023 (09:09:09 CEST)
REVIEW
|
doi:10.20944/preprints202402.0153.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
angiotensin-converting enzyme(ACE); angiotensin-converting enzyme inhibitors (ACEi); angioedema; bradykinin mediated angioedema; tratement of ACEi induced AE
Online: 2 February 2024 (11:53:14 CET)
REVIEW
|
doi:10.20944/preprints202305.0122.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Non-small cell lung cancer (NSCLC); EGFR; Tyrosine kinase inhibitors (TKIs); Uncommon mutation; Compound mutation; Intracranial activity; Immunotherapy
Online: 3 May 2023 (09:29:08 CEST)
ARTICLE
|
doi:10.20944/preprints201811.0609.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
immune checkpoint inhibitors; immune-related adverse events (irAEs); tolerance; ipilimumab; nivolumab; interleukin-2; hyperthermia; low-dose-combination therapy
Online: 28 November 2018 (10:23:31 CET)
REVIEW
|
doi:10.20944/preprints202401.0165.v1
Subject:
Medicine And Pharmacology,
Pulmonary And Respiratory Medicine
Keywords:
lung vascular endothelium; endothelial barrier integrity; zinc-dependent HDACs; deacetylation; HDAC inhibitors; acute lung injury; acute respiratory distress syndrome
Online: 3 January 2024 (07:42:38 CET)
ARTICLE
|
doi:10.20944/preprints202104.0270.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
Systemic amyloidosis; amyloid fibrils; amyloidogenesis inhibitors; antibody light chains; light chain stabilizers; doxycycline; EGCG; thioflavin T; filter trap; PAINS
Online: 9 April 2021 (15:07:24 CEST)
REVIEW
|
doi:10.20944/preprints202402.1384.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Cystic fibrosis; Pseudomonas aeruginosa; Antivirulence therapy; Quorum quenching and biofilm inhibition; Lectin and efflux pump inhibitors; Iron chelation
Online: 23 February 2024 (15:01:30 CET)
ARTICLE
|
doi:10.20944/preprints202110.0297.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
gastric cancer; immunotherapy; immune checkpoint blockade (ICB); immune checkpoint inhibitors (ICI),; DNA repair gene signature (DRGS); prognostic biomarker; score system
Online: 20 October 2021 (22:47:19 CEST)
REVIEW
|
doi:10.20944/preprints201902.0101.v1
Subject:
Medicine And Pharmacology,
Ophthalmology
Keywords:
age-related macular degeneration; anti-inflammatory agents; dry AMD; geographic atrophy; intravitreal injection; complement inhibitors; neuroprotective agents; non-exudative AMD
Online: 12 February 2019 (11:00:52 CET)
REVIEW
|
doi:10.20944/preprints202103.0262.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
immune checkpoint inhibitors; immune checkpoint radiolabeled antibodies; PD-1; PD-L1; immune PET; immunotherapy; AI; Radiomics; Deep learning; CAR-T cells
Online: 9 March 2021 (11:12:55 CET)
ARTICLE
|
doi:10.20944/preprints202305.0276.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
fibroblast activation protein α (FAP-α); cancer-associated fibroblasts (CAFs); FAP inhibitors (FAPIs); PET imaging; gallium-68; (R)-pyrrolidin-2-yl-boronic acid-based radiopharmaceuticals
Online: 5 May 2023 (02:40:01 CEST)
ARTICLE
|
doi:10.20944/preprints202201.0380.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
Therapeutic biomarkers; circulating tumor cells; Immunocytochemistry; targeted therapy; Fluorescence in situ hybridization (FISH); Immune Checkpoint Inhibitors; Liquid Biopsy; Hormonal Treatments; Breast Cancer; Lung Cancer
Online: 25 January 2022 (11:31:05 CET)
ARTICLE
|
doi:10.20944/preprints201812.0064.v1
Subject:
Biology And Life Sciences,
Other
Keywords:
combinatorial search forest; sensitivity analysis; support vector ranking algorithm; unknown biological hypotheses; Wnt pathway; PORCN-WNT inhibitors; ETC-1922159; Sobol indices; Hilbert Schmidt independence criterion indices (HSIC); F-divergence (Fdiv); systems biology
Online: 5 December 2018 (07:52:17 CET)