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Preprint REVIEW | doi:10.20944/preprints202104.0078.v1

Influence Factors Psychological and Stigma During the COVID-19 Pandemic: Literature Review

Joko Susanto, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Psychological; Stigma; Covid-19

Online: 2 April 2021 (17:02:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0709.v1

COVID-19 Suicide among Adolescents and Youths during the Lockdown: An Exploratory Study based on Media Reports

Md. Dilshad Manzar, Abdulrhman Albougami, Norina Usman, Mohammed A. Mamun

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; lockdown; psychological impacts; self-harm; suicide; COVID-19 suicide; teenage suicide; adolescent suicide; youth suicide; press reporting suicide

Online: 31 August 2020 (05:43:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0742.v1

A Single Dose of Psilocybin Increases Synaptic Density and Decreases 5-HT2A Receptor Density in the Pig Brain

Nakul Ravi Raval, Annette Johansen, Lene Lundgaard Donovan, Nídia Fernandez Ros, Brice Ozenne, Hanne Demant Hansen, Gitte Moos Knudsen

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Psilocybin; psychedelics; neuroplasticity; SV2A; 5-HT2A; depression; autoradiography; functional-selectivity

Online: 30 November 2020 (16:30:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0380.v3

Infodemiological Study on COVID-19 Epidemic and COVID-19 Infodemic

Zhiwen Hu, Zhongliang Yang, Qi Li, An Zhang, Yongfeng Huang

Subject: Social Sciences, Psychology Keywords: Infodemiology; COVID-19 infodemic; social contagion; collective perceptual bias; collective behavioral propensities; psychological typhoon eye effect

Online: 16 March 2020 (15:12:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202012.0367.v1

Impact of COVID-19 Pandemic on Mental Health of University Students in Pakistan

Hafiz Muhammad Asif, Hafiz Abdul Sattar

Subject: Social Sciences, Psychology Keywords: Psychosocial impact; anxiety; Covid-19 stressors; policies; public health emergencies; pandemics

Online: 15 December 2020 (10:17:13 CET)

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Purpose: A novel coronavirus, SARS-CoV-2 was identified as the cause of COVID-19 eventually led to the declaration of Public health emergency of international concern and a pandemic by WHO due to its exponential global spread. Present study was conducted to investigate the impact of second wave of pandemic on mental wellbeing and social behaviors among university students of Pakistan during this crucial period of COVID-19 infection. Methods: A cross-sectional analytical study was designed to evaluate the psychosocial impact during the current COVID-19 outbreak among the students of The Islamia University of Bahawalpur, Pakistan. Snowball sampling or chain referral sampling procedure was adopted to recruit the participants in the study. Verbal informed consent was taken from all participants before recruitment in the study irrespective of their gender, age and socioeconomic status. Results: Mental health of university students during COVID-19 epidemic was affected to a varying degree revealing that 26.66% were recorded to have mild, 27.15% moderate and 17.04% suffering from severe anxiety out of total 1029 students. Students who were residing in urban areas with parents and having a steady family income were negatively associated and found protective factors against anxiety. However, having a relative or an acquaintance infected with COVID-19 was an independent risk factor for experienced anxiety. Positively associated factors with the level of anxiety symptoms included economic stressors, effects on daily-life, and academic delays whereas social support was negatively correlated with anxiety in COVID-19 related stressors. Conclusion: Public health emergencies and such pandemic are exerting serious psychological impacts on university students. It is recommended that the higher authorities should plan better policies to reduce this impact for the provision of high quality and timely crisis-oriented psychological services to university students.

Preprint ESSAY | doi:10.20944/preprints201612.0083.v1

Depression Measurement Instruments: An Overview of the Top Depression Rating Scales

John H. Morgan

Subject: Social Sciences, Sociology Keywords: depression; measurement scale; ratings; literature review

Online: 16 December 2016 (07:57:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0418.v1

Analyzing academic stress in adolescence and their relationship with students’ psychological and physical well-being: Development and validation of the Questionnaire of Academic Stress in Secondary Education

Rafael García-Ros, Francisco Pérez-González, José M. Tomás

Subject: Social Sciences, Psychology Keywords: academic stress; psychological and physical well-being; adolescence; secondary education; validity; reliability; gender and age differences

Online: 23 August 2018 (15:32:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0093.v2

Mental Health in Cypriot Citizens of the Rural Health Centre Kofinou

Georgios Stavrou, Eleni Jelastopulu, Lefkios Paikousis, Georgios Charalambous

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; anxiety; emotional distress; HADS; GDS; Health Centre

Online: 11 August 2016 (11:05:44 CEST)

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Objective: The main purpose of this study was to investigate the mental health of Cypriot citizens, living in the current difficult period of economic recession. Specific objective was to investigate the different factors (gender, age, socio-economic factors, etc.) that may affect the levels of emotional distress, anxiety and depression in visitors of the Rural Health Centre of Kofinou. Materials and Methods: The sample consisted of total 300 Cypriots who visited Kofinou Health Centre in the period between August and September 2015. For the middle-aged citizens the Greek version of the HADS scale (Hospital Anxiety Depression Scale) was administered to 150 persons (Michopoulos I., 2007), while for the visiting senior citizens (aged over 65 years) the Greek version of the GDS scale (Geriatric Depression Scale) was used (Fountoulakis K., et al., 1999). All analyses were performed with the social science analysis package SPSS (version 21). Results: HADS: A total of 150 people of average age 47±11,5 years (23-64), were 56% women, while the 77.3% stated they had drastic reduction of income as well as 46.7% suffered from chronic disease. The 36.6% and 28.7% of the visitors showed moderate and severe forms of anxiety and depression, accordingly. Higher emotional distress is associated with lower educational level (p<0,001). Moreover, patients with low income have higher levels of anxiety (p=0,003), depression (p=0,036) and total emotional distress (p=0,007), while those with chronic disease have a higher stress (p<0,001), depression (p<0,001) and total emotional distress symptoms (p<0,001) compared to non - patients. GDS: 150 patients out of which 77 were women (51.3%). The average age of participants was 72±5,5 years. 93(62%) participants declared a drastic reduction of income due to the financial crisis while 139 (92.7%) stated they had chronic disease. 53 participants (35.3%) think they have symptoms of depression after the economic crisis. The women showed higher level of geriatric depression symptoms than men (p<0.001). Higher levels of depression is associated with lower income (p=0.001). Conclusions: The study shows that stress levels, depression and emotional distress are increased in specific population groups. The main factors affecting the mental health of the participants are the presence of chronic disease, income and level of education.

Preprint ARTICLE | doi:10.20944/preprints201701.0138.v1

Danggui-Shaoyao-San, a Traditional Chinese Medicine, Relieved Depression and Cognitive Disorder Induced by Chronic Restraint Stress Involved in Regulating Dendritic Spines Remodeling

Kecheng Zhou, Junbin Yin, Huanghui Wu, Wei Hu, Zhen Gao, Fang Li, An'an Wu, Wen Wang, Junping Kou

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: Danggui-Shaoyao-San, chronic restraint stress, learning and memory, anxiety/depression, structural plasticity

Online: 31 January 2017 (15:30:41 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202005.0255.v1

Waves of Mental Health Demands During the COVID-19 Pandemic

Eduardo Honorato

Subject: Social Sciences, Psychology Keywords: COVID-19; Mental Health; Psychological Symptoms

Online: 15 May 2020 (15:17:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0030.v2

Using the Job Burden-Capital Model of Occupational Stress to Predict Depression and Well-Being among Electronic Manufacturing Service Employees in China

Chao Wang, Shuang Li, Tao Li, Shanfa Yu, Junming Dai, Xiaoman Liu, Xiaojun Zhu, Yuqing Ji, Jin Wang

Subject: Social Sciences, Psychology Keywords: occupational stress; job burden-capital model; structural equation model; depression; well-being

Online: 4 August 2016 (12:47:57 CEST)

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Working Paper REVIEW

A New Perspective of Genetic Associations to the Cause of Multiple Sclerosis: The Role of Genes Expressed on Chromosomes 2 and 5

Robin Terese Montesano

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: multiple sclerosis; MS; cause; genes; polygenic; heredity; autoimmune; diet; depression; fatigue; suicide; seizures; bowel disorders; thyroid; mitochondria; chromosome 2; chromosome 5; glial cells; sunlight; vitamin D3; ultraviolet radiation; melanocyte stimulating hormone; melanocyte concentrating hormone; stress

Online: 22 July 2019 (04:37:27 CEST)

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The literature on the causation of multiple sclerosis (MS), both genetic and environmental, extends over hundreds of years, with no firm conclusions on the exact role of autoimmunity and lifestyle. The epidemiology of MS was the basis for this review, but with a new, extensive examination of genes pertaining to each disorder, and disease of first, and second, degree relatives of those with MS. The author’s motivation was to discover some relationship between MS, and notable familial conditions, as the heredity of MS is concluded to be 30%, and the disorders had a chronic and/or idiopathic nature. This investigation hoped to further understand the randomness of MS- who acquires it, and what symptoms develop- after the author’s decades of observing several incidences of multiple members developing MS in a single family. Online databases for the human genome were used to link genes to MS, and symptoms, including excessive depression, fatigue and suicide rates, in coordination with linking genes for specific familial conditions including seizures, stroke, mental illness, bowel disorders, and thyroid conditions. Interesting associations were found, notably a cluster of Th2 cytokines, known to cure the animal model of MS, important receptors for neurotransmitters and hormones, a gene specific to Epstein Barr Virus, and potential genes for mitochondrial dysfunction. The results surprised the author, showing polygenic regions of chromosome 2 and 5, especially a cluster at loci 5q31-q33, may be dysregulated. The conclusion agrees with past hypotheses MS results not from a single gene, but from various genes, including those expressed in glial cells. The individual theories to the causation of MS, starting with Charcot may be explained by multiple pathways converging into a single disease outcome. In coordination with a sunlight factor, chromosome 2 appears to mediate the immune system, and inflammation, through ultraviolet radiation producing vitamin D3 in the skin, but additionally through peptides formed in the melanocyte stimulating and concentrating hormone class. The impact of stress in MS could be primary, given the loci of several stress-related and stress-modulated genes on these chromosomes, and calls for more appreciation of, and greater care for, the MS patients’ state of mind.

Preprint ARTICLE | doi:10.20944/preprints201608.0049.v2

Understanding Farmers’ Decision Making in Agricultural Water Fee Payment in China: The Role of Mental Accounting

Weikang Zhang, Xinhong Fu, Jing Lu, Lin Zhang, Kwamega Michael, Guoqiang Liu, Yuying Liu, Fan Yang

Subject: Business, Economics And Management, Economics Keywords: mental accounting; agricultural water fee; behavioral economics; decision making; information processing; representativeness; negative psychological externalities

Online: 25 August 2016 (10:12:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0013.v1

Social Support and Emotional Maturity to Reduce Students’ Online Learning Anxiety During the Covid-19 Pandemic

Andik Matulessy, Sahat Saragih, Nawafil Nawafil, Hengki Perdana, Moses Pandin

Subject: Social Sciences, Education Keywords: Social support; emotional maturity; anxiety; online learning

Online: 4 January 2021 (11:26:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0226.v1

What Are Your Children Watching? Teacher’s Evaluation of the Educational, Emotional, Behavioral, Psychological, Physical & Religious impacts of Cartoons on the School Going Children

Syed Hassan Raza, Sarfraz Gondal, Sajid Mehmood Awan

Subject: Social Sciences, Psychology Keywords: educational impacts; emotional impacts; behavioral impacts; psychological impacts; physical impacts; religious impacts

Online: 29 August 2016 (12:24:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0041.v1

Assessing the Attitudes and Clinical Practices of Ohio Dentists Treating Patients with Dental Anxiety

Kristin A. Williams, Sarah Lambaria, Sara Askounes

Subject: Medicine And Pharmacology, Dentistry And Oral Surgery Keywords: dental anxiety; dental fear; anxiolytics; nitrous oxide

Online: 12 September 2016 (10:32:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0090.v1

A Pilot Study on the Effectiveness of a Heat-Pain Stimulus to Induce Pain, Anxiety, and Fear

Guillaume Durand

Subject: Social Sciences, Psychology Keywords: heat-pain; pilot study; anxiety; fear; psychopathy

Online: 24 February 2017 (07:18:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0654.v1

A Hybrid Deep Learning Model to Predict the Impact of COVID-19 on Mental Health form Social Media Big Data

Tapotosh Ghosh, Md. Hasan Al Banna, Md. Jaber Al Nahian, Kazi Abu Taher, M Shamim Kaiser, Mufti Mahmud

Subject: Computer Science And Mathematics, Data Structures, Algorithms And Complexity Keywords: COVID-19; Mental Health; Depression; Big data; Social media.

Online: 28 June 2021 (13:50:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0331.v1

Determining Symptomatic Factors of Nomophobia in Peruvian Students from the National University of Engineering

Jimmy Aurelio Rosales-Huamani, Rita Rocio Guzman-Lopez, Eder Eliseo Aroni-Vilca, Carmen Rosalia Matos-Avalos, Jose Luis Castillo-Sequera

Subject: Social Sciences, Behavior Sciences Keywords: nomophobia; anxiety; phobia; panic.

Online: 31 January 2019 (16:01:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201704.0041.v1

Association between Excessive Use of Mobile Phone and Insomnia and Depression among Japanese Adolescents

Tamura Haruka, Tomoko Nishida, Akiyo Tsuji, Hisataka Sakakibara

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: adolescents; depression; insomnia; mobile phone; Japanese

Online: 7 April 2017 (04:33:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0093.v1

Problems in Speaking Performance of Grade 8 Jade of Tagum City National High School

Genesis Genelza, Floree Jean Lapined, Sarah Jane Suarez, Merry Ann Alvez, Clarice Cabrera, Rachell Sabandal

Subject: Social Sciences, Language And Linguistics Keywords: anxiety; low participation; mother tongue; speaking performance

Online: 7 May 2022 (05:36:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0077.v1

Effects of Forest Therapy on Depressive Symptoms among Adults: A Systematic Review

Insook Lee, Heeseung Choi, Kyung-Sook Bang, Sungjae Kim, MinKyung Song, Buhyun Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: systematic review; forest therapy; depression; adults

Online: 14 March 2017 (08:45:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0463.v1

Burnout Prevalence and Its Associating Factors among Malaysian Healthcare Workers during COVID-19 Pandemic: An Embedded Mixed-Method Study

Nurhanis Syazni Roslan, Muhamad Saiful Bahri Yusoff, Asrenee Ab Razak, Karen Morgan

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: psychological wellbeing; burnout; health personnel; caregiver; pandemic

Online: 18 December 2020 (11:58:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0026.v2

Life Perceptions, Problems and Psychological Wellbeing in Preadolescent and Adolescent Patients in Treatment for Leukemia Compared with Healthy Peers

Marta Tremolada, Ilaria Tamara Chiavetta

Subject: Social Sciences, Psychology Keywords: children; adolescents; leukemia; in treatment; healthy peers; life perceptions; psychological wellbeing; reported problems

Online: 4 February 2019 (13:52:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0278.v1

Psychological Risks of Resettlers in Resettlement Planning: A Study in Moragahakanda Resettlement Project (MRP)

Rangajeewa Ratnayake, Hansani Disanayake

Subject: Arts And Humanities, Humanities Keywords: resettlement; psychological risks; development-induced displacement

Online: 30 January 2018 (06:48:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0559.v1

Depression, Anxiety and Stress among Health Care Professionals on Duty in COVID-19 Wards

Maham Noor Afroz, Syeda Maria Hassan, Kanwal Bansari, Humza Faisal Siddiqui, Sana Irfan, Basma Ali, Hamza Sohail, Zoha Batool, Muhammad Khizar Memon, Sidra Memon, Faizan Shaukat

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Stress; Anxiety; Depression; HCPs; COVID-19

Online: 27 October 2020 (15:27:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0014.v1

The Depression Anxiety Stress Scale 21: Development and Validation of the Depression Anxiety Stress Scale 8-item in Psychiatric Patients and the General Public for Easier Mental Health Measurement in a Post-COVID-19 World

Amira Ali, Abdulmajeed A. Alkhamees, Hiroaki Hori, Yoshiharu Kim, Hiroshi Kunugi

Subject: Social Sciences, Psychology Keywords: Coronavirus disease 2019/COVID-19; Depression Anxiety Stress Scales-21/DASS-21; DASS-8; shortened version*; shorter version* of the DASS-21; psychiatric disorders; factorial structure/psychometric properties/structural validity/validation; measurement invariance/multigroup analysis; psychological distress; discriminant validity; item coverage; good predictive validity

Online: 1 September 2021 (12:15:27 CEST)

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Despite extensive investigations of the Depression Anxiety Stress Scales-21 (DASS-21) since its development in 1995, its factor structure and other psychometric properties still need to be firmly established, with several calls for revising its item structure. Employing confirmatory factor analysis (CFA), this study examined the factor structure of the DASS-21 and five shortened versions of the DASS-21 among psychiatric patients (N = 168) and the general public (N = 992) during the COVID-19 confinement period in Saudi Arabia. Multigroup CFA, Mann Whitney W test, Spearman’s correlation, and coefficient alpha were used to examine the shortened versions of the DASS-21 (DASS-13, DASS-12, DASS-9 (two versions), and DASS-8) for invariance across age and gender groups, discriminant validity, predictive validity, item coverage, and internal consistency, respectively. Compared with the DASS-21, all three-factor structures of the shortened versions expressed good fit, with the DASS-8 demonstrating the best fit and highest item loadings on the corresponding factors in both samples (χ2(16, 15) = 16.5, 67.0; p = 0.420, 0.000; CFI= 1.000, 0.998; TLI = 0.999, 0.997; RMSEA = 0.013, 0.059, SRMR = 0.0186, 0.0203). It expressed configural, metric, and scalar invariance across age and gender groups. Its internal consistency was comparable to other versions (α = 0.94). Strong positive correlations of the DASS-8 and its subscales with the DASS-21 and its subscales (r = 0.97 to 0.81) suggest adequate item coverage and good predictive validity of this version. The DASS-8 and its subscales distinguished the clinical sample from the general public at the same level of significance expressed by the DASS-21 and other shortened versions, supporting its discriminant validity. Neither the DASS-21 nor the shortened versions distinguished patients diagnosed with depression and anxiety from other conditions. The DASS-8 represents a valid short version of the DASS-21, which may be useful in research and clinical practice for quick identification of individuals with potential psychopathologies. Diagnosing depression/anxiety disorders may be further confirmed in a next step by clinician-facilitated examinations. Brevity of the DASS-21 would save time and effort used for filling the questionnaire and support comprehensive assessments by allowing the inclusion of more measures on test batteries.

Preprint ARTICLE | doi:10.20944/preprints202006.0356.v1

The Psychological Impact of COVID-19 Pandemic among Communities Living in Dilla Town, Ethiopia, April 2020

Chalachew Kassaw

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: anxiety; depression; stress; coronavirus; Dilla; Ethiopia

Online: 30 June 2020 (08:00:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0093.v1

Identification of Research Priorities in Infertility and Assisted Reproduction: An International, Multicenter Study in Partnership with Patients

D García, F Lindenberg, E Toft, A La Marca, R Borrás, AR Lorenzon, MB Chehin, L Silva, ELA Motta, M Ripero, j Madero, RM Marinho, CA Oliveira, JPJ Caetano, A Bolívar, S Brazal, A Rodríguez, R Vassena

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Patients involvement; research interests; ART treatments; treatment personalization; psychological effects; healthy habits; fertility protection; infertility prevention; lifestyle; diet

Online: 8 April 2019 (12:46:17 CEST)

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STUDY QUESTION: Which are the main research interests among patients of assisted reproductive technologies (ART)? SUMMARY ANSWER: Patients identified as research priorities that deserve further investigation: success rates and risks of ART, side-effects of treatments, resources to cope with infertility, effectiveness of alternative therapies, lifestyle habits to protect fertility, oocyte quality and ovarian reserve, and causes of genetic or hereditary infertility. WHAT IS KNOWN ALREADY: The involvement of patients and caregivers in setting research agendas in medicine has gathered significant momentum in the last decade. Patients’ involvement in setting research priorities offers several benefits: improved patient knowledge and awareness of their condition; greater understanding of the medical professionals of the impact of the condition on patients’ quality of life; reduced costs associated with redundant research activities. This is may be also applicable to research in infertility and ART, where patients’ interests have never been explored before. STUDY DESIGN, SIZE, DURATION: This is a cross-sectional study that consists of an anonymous online survey, which was sent up to three times to 2112 patients from 11 fertility centers in 5 countries between January-December 2018. The study design was based on the James Lind Alliance priority setting partnership model, which comprises the identification of patients groups, the exploration of the research agenda, the analysis of collected data and identification of priorities. PARTICIPANTS/MATERIALS, SETTING, METHODS: Overall, 2112 patients were contacted, and 945 surveys were answered (RR: 44.7%). Patients were asked to identify research questions relevant to them in the areas of infertility causes and prevention, fertility treatments (medication and ART), and the emotional aspects of infertility. Answers were categorized in topics and ranked by frequency. A long list of the top-30 research topics was extracted from the aggregate results, from which, a short list of the top-10 research topics was created. At the end, 10 research questions related to each of the 10 research topics were constructed, based on the answers given by patients. MAIN RESULTS AND THE ROLE OF CHANCE: Female (845, 89.4%) and male (100, 10.6%) patients were included. The mean age of patients was 37.8 (SD 1.74). Most of the patients did not have children at the time of the survey (523, 59%), while 51 (5.7%) were pregnant. Sixty (6.3%) patients did not start treatment, 579 (61.3%) were performing a treatment with their own gametes and 304 (32.2%) were treated through gamete donation. Patients were mainly interested in the effectiveness of ART -especially per clinical profile-, side effects of drugs, protection of fertility and prevention of infertility –especially through diet and exercise-, and psychological aspects of the infertility journey. The top-10 research questions (and weight) obtained were: 1) What are the side-effects of ART treatments? (41.6%); 2) What are the most effective methods to cope with infertility from the psychological point of view? (37.2%); 3) What effects could diet have on fertility? (25.9%); 4) What are ART success rates per clinical profile? (25.9%); 5) Are there habits and lifestyle factors that could prevent infertility? (20.0%); 6) What are the long-term risks associated to ART? (18.5%); 7) Are alternative therapies such as acupuncture, yoga, and meditation effective to treat/prevent infertility? (18.5%); 8) What is the impact of exercise on fertility? (15.4%); 9) How does oocytes quantity and quality affect fertility? (9.5%); 10) What are the genetic patterns or hereditary conditions causing/related to infertility? (9.5%). LIMITATIONS, REASONS FOR CAUTION: Although all respondents had attended a fertility center, not all of them were diagnosed as infertile (i.e. single women) and had started treatment at the time of response, while a few were pregnant; their priorities for research might have been influenced by their infertility journey. Also, all participants attended private fertility centers: areas of interest may be different in public settings. WIDER IMPLICATIONS FOR THE FINDINGS: Researchers and clinicians should keep in mind that, in addition to improvement of treatments’ success rates and side-effects, patients greatly value research on causes, prevention and emotional aspects of infertility. As their views might differ from those of medical professionals, patients’ voices should be incorporated in setting infertility research priorities.

Preprint ARTICLE | doi:10.20944/preprints202202.0028.v1

Social Media Addiction and Emotions During the Disaster Recovery Period? – The Moderating Role of Post-COVID Timing

Dewan Muhammad Nur -A Yazdani, Tanvir Abir, Qing Yang, Jamee Ahmad, Abdullah Al Mamun, Noor Raihani Zainol, Kaniz Kakon, Shasha Wang, Kingsley E Agho

Subject: Social Sciences, Psychology Keywords: social media; addiction; anxiety; fear; health issues

Online: 2 February 2022 (10:53:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0006.v1

The differences between the Connor–Davidson Resilience Scale and the Brief Resilience Scale When Assessing Resilience: Confirmatory Factor Analysis and Predictive Effects

Yun-Ci Ye, Chia-Huei Wu, Cheng-Ta Yang

Subject: Social Sciences, Psychology Keywords: resilience; Connor-Davidson Resilience Scale; Brief Resilience Scale; depression; life satisfaction; confirmatory factor analysis

Online: 4 January 2022 (12:34:37 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0148.v1

Play Therapy to Reduce Anxiety in Children

Wahyu Endang Setyowati, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: play therapy; anxiety; children

Online: 5 April 2021 (14:33:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0381.v1

Perceived Stress, Depression and Alcohol Use Disorders in College Students During the COVID-19 Pandemic: A Socio-Economic Dimension

Beata Gavurova, Viera Ivankova, Martin Rigelsky

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alcohol dependence; Depression; Stress; Gender; Income; Differences; Behavioural disorders; Mental disorders; Socio-economic effects; Pandemic; Isolation; COVID-19; Slovak students

Online: 13 November 2020 (13:24:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0435.v1

Lifestyle Habits and Mental Health in Light of the Two COVID-19 Pandemic Waves in Sweden, 2020

Victoria Blom, Amanda Lonn, Björn Ekblom, Lena.V. Kallings, Daniel Väisänen, Erik Hemmingsson, Gunnar Andersson, Peter Wallin, Andreas Stenling, Örjan Ekblom, Magnus Lindwall, Jane Salier Eriksson, Tobias Holmlund, Elin Ekblom-Bak

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Physical activity; Sitting; Alcohol; Diet; Smoking; SARS-CoV-2; Sweden; Mental health; Health anxiety; Depression

Online: 19 February 2021 (10:07:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0053.v1

Protective Factors and Teachers’ Risk to Burnout during the Covid-19 Pandemic. Do Kolb’s Educator Roles Matter? - A Cluster Analysis

Camelia-Mădălina Răducu, Elena Stănculescu

Subject: Business, Economics And Management, Accounting And Taxation Keywords: teacher burnout; well-being; self-control; positive emotionality; professional experience; psychological profile; COVID-19

Online: 2 August 2021 (15:32:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0124.v1

Listening Music in Reducing Anxiety for Regional Anesthesia Cases

Mohd Rahmat Bin Abd Hamid, Marzida Binti Mansor, Mohd Fitry Bin Zainalabdin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Anesthesia; Anxiety; Regional anaesthesia; Music Therapy

Online: 6 July 2021 (08:15:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0651.v1

Impact of Pre-Exam Anxiety on the Academic Performance of Final Year Medical Students

Hamza Sohail, Syeda Maria Hassan, Basma Ali, Sana Irfan, Humza Faisal Siddiqui, Kanwal Bansari, Maham Noor Afroz, Zoha Batool, Faizan Shaukat

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Pre-exam anxiety; Poor academic performance; GPA

Online: 30 October 2020 (15:49:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0395.v1

Quantum-Like Cognition and Rationality: Biological and Artificial Intelligence Systems

Andrei Khrennikov

Subject: Social Sciences, Psychology Keywords: mathematical formalism; quantum mechanics; quantum instruments; psychological effects; cognition; decision making; classical rationality; quantum rationality; information overload

Online: 15 March 2021 (14:12:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202208.0227.v1

Differences in the Course of depression and anxiety After COVID-19 Infection Between Recovered Patients With and Without a Psychiatric History: A Cross-Sectional Study

Megumi Hazumi, Kentaro Usuda, Emi Okazaki, Mayumi Kataoka, Daisuke Nishi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; depression; anxiety; post-acute COVID-19 syndrome; post-COVID

Online: 12 August 2022 (04:56:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201910.0290.v1

The Impact of the Cinema on Young People (on the Example of the Changes of the Representation of the Elderly)

Tina Kubrak

Subject: Social Sciences, Psychology Keywords: psychology of cinema; influence of mass media; psychological influence of cinema; representations of youth; image of the elderly person

Online: 27 October 2019 (03:02:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0033.v1

Major Depression in Children with β-Thalassemia Major is Strongly Associated with the Number of Blood Transfusions, Iron Overload and Increased Levels of Interleukin-1β

Hussein Kadhem Al-Hakeim, Asawer Hassan Najm, Arafat Hussein Al-Aldujaili, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; cytokines; neuro-immune; inflammation; oxidative stress; antioxidants

Online: 3 September 2019 (16:20:18 CEST)

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Working Paper REVIEW

A Review on Mitigating Fear and Aggression in Dogs and Cats in a Veterinary Setting

Stefanie Riemer, Carmen Heritier, Ines Windschnurer, Christine Arhant, Lydia Pratsch, Nadja Affenzeller

Subject: Biology And Life Sciences, Animal Science, Veterinary Science And Zoology Keywords: Stress; fear; anxiety; aggression; veterinary visit; low-stress handling; counterconditioning; behaviour modification; anxiolytic medication; psychoactive drugs; dogs; cats

Online: 8 January 2021 (14:37:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202002.0084.v1

The Microbiota-gut-immune-glia (MGIG) Axis in Major Depression

Leszek Rudzki, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; leaky gut; microbiota; cytokines; neuroimmunomodulation; oxidative stress

Online: 6 February 2020 (10:30:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0625.v3

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Science in Mood and Anxiety Disorders

Lehel Balogh, Masaru Tanaka, Nóra Török, László Vécsei, Shigeru Taguchi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; anxiety disorders; existential psychotherapy; logotherapy; meaning-centered psychotherapy; functional magnetic resonance imaging; biomarker; kynurenines; Martin Heidegger; Viktor Frankl

Online: 24 March 2021 (13:18:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0485.v1

Short-term Psychological Effects of Forest Therapy: Early Evidence in Italy

Francesco Meneguzzo, Lorenzo Albanese, Michele Antonelli, Rita Baraldi, Francesco Riccardo Becheri, Francesco Centritto, Davide Donelli, Franco Finelli, Fabio Firenzuoli, Giovanni Margheritini, Valentina Maggini, Sara Nardini, Marta Regina, Federica Zabini, Luisa Neri

Subject: Social Sciences, Psychology Keywords: anger; anxiety; confusion; depression; fatigue; forest therapy; mental health; vigor; volatile organic compounds

Online: 20 May 2021 (11:22:20 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202005.0018.v1

Preparing for the COVID-19 Mental Health Crisis in Latin America – Using Early Evidence From Countries That Experienced COVID-19 First

Alberto Abad, Juliana Almeida Da Silva, João Vitor Zamana das Neves Braga, Priscila Medeiros, Renato Leonardo De Freitas, Norberto Cysne Coimbra, José Aparecido Da Silva

Subject: Social Sciences, Psychology Keywords: mental health; COVID-19; psychological reactions

Online: 2 May 2020 (15:59:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0114.v2

Complementary and Alternative Therapy for Pain and Anxiety in Cardiovascular Disease: A Literature Review

Indah Sri Wahyuningsih, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Anxiety, complementary therapies, coronary artery disease, pain

Online: 15 April 2021 (12:56:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0298.v1

My Mind is Working Overtime – Towards an Integrative Perspective of Psychological Detachment, Work-Related Rumination and Work Reflection

Oliver Weigelt, Petra Gierer, Christine J. Syrek

Subject: Social Sciences, Psychology Keywords: rumination; psychological detachment; perseverative cognition; work reflection; vitality; burnout; thriving; work engagement; employee well-being; mental health

Online: 28 June 2019 (12:09:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0344.v1

Religious Pluralism and Decolonization of Indian Mind

Ilya Shmelev, Oleg Pavenkov, Elena Starovoytenko

Subject: Social Sciences, Religion Keywords: religious pluralism; decolonization of mind; semi-structured interview; psychological features; Hinduism; Indian culture; religious rights of human

Online: 29 May 2019 (05:03:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0423.v1

Psychological Distress and Well-Being among Students of Health Disciplines: The Importance of Academic Satisfaction in the Context of Academic Year-End and COVID-19 Stress

Nguyen Toan Tran, Jessica Franzen, Françoise Jermann, Serge Rudaz, Guido Bondolfi, Paolo Ghisletta

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: mental health; psychological well-being; depression; anxiety; stress; COVID-19; students' academic satisfaction; undergraduate students; Bachelor's degree students

Online: 16 March 2021 (12:20:50 CET)

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Background University students’ psychological health is linked to their academic satisfaction. This study aimed to investigate students’ psychological health and academic satisfaction in the context of COVID-19 and academic year-end stress. Methods Standardized self-filled scales for anxiety, depression, stress, psychological well-being, and an ad-hoc COVID-19 stress scale were used in this cross-sectional study. Participants were first- to third-year students of eight different health-related tracks in Geneva, Switzerland. Descriptive statistics and hierarchical regression analyses were applied. Results In June 2020, out of 2835 invited students, 433 (15%) completed the survey. Academic satisfaction was a stronger mental health predictor than COVID-19, which mainly predicted stress and anxiety. Lower academic satisfaction scores were significantly associated with stress (β = -.53, p < .001), depression (β = -.26, p < .001), anxiety (β = -.20, p < .001), while higher scores with psychological well-being (β = .48, p < .001). Being female was strongly associated with anxiety and stress but not with depression or psychological well-being. Lower age was associated with stress only. The nature of the academic training had a lesser impact on mental health and the academic year none. Compared to students starting the academic year, year-end students reported significantly lower academic satisfaction, higher depression, and particularly higher anxiety and stress. There was, however, no difference in psychological well-being. Conclusion Students suffer more from anxiety, stress, depression, and lower satisfaction with studies at the end of the academic year than at the beginning. Academic satisfaction plays a more substantial role than COVID-19 in predicting students’ overall mental health status. Training institutions should address the underlying factors that can enhance students’ academic satisfaction, especially during the COVID-19 period, in addition to ensuring that they have a continuous and adequate learning experience, as well as access to psychosocial services that help them cope with mental distress and enhance their psychological well-being.

Preprint REVIEW | doi:10.20944/preprints201805.0177.v1

Hippocampal Volume Changes in Patients with Mood Disorders: A Systematic Review of MRI Studies

Marcelo Antônio Oliveira Santos, Lucas Soares Bezerra, Alessandra Mertens Brainer-Lima, Ana Rita Ribeiro Marinho Carvalho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: hippocampus volume; mood Disorders; MRI; depression; subiculum; CA1

Online: 11 May 2018 (06:32:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0064.v1

Few Sex Differences in Hospitalized Suicide Attempters Aged 70 and Above

Stefan Wiktorsson, Therese Rydberg Sterner, Madeleine Mellqvist Fässberg, Ingmar Skoog, Anne Ingeborg Berg, Paul Duberstein, Kimberly Van Orden, Margda Waern

Subject: Social Sciences, Psychology Keywords: sex differences; suicide attempt; late life; depression; physical disability

Online: 11 December 2017 (13:04:01 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202004.0197.v2

Mental Health and COVID - 19: An Action Plan

Giulia Simonetti, Carmela Iosco, Gianfranco Taruschio

Subject: Social Sciences, Psychology Keywords: COVID-19; Post Traumatic Stress Disorder (PTSD); victims; psychological problems; counseling

Online: 30 April 2020 (05:40:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0176.v1

In Major Depression, Increased Serum Dynorphin and Kappa Opioid Receptor Levels are Positively Associated with Mu Opioid Receptor Levels and Immune Activation and Are Attenuated by Nicotine Dependence

Hussein Al-Hakeim, Suhaer Al-Fadhel, Arafat Hussein Al-Dujaili, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; cytokines; inflammation; endogenous opioid; opioid receptor

Online: 16 April 2019 (09:49:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0579.v1

A Study on Spinsterhood in Morocco: Students’ Attitudes towards Spinsterhood, FLDM, Fez

Sofian Herouach

Subject: Social Sciences, Sociology Keywords: unmarried women; modernity and individuality; education and career priorities; social stigma; social pressure; psychological influences

Online: 30 July 2018 (10:19:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0306.v1

Relationship between FoMO, Problematic Social Media Use, Self-Esteem, Negative Affectivity and Physical Exercise. A Structural Equation Model

Anastasios Dadiotis, Petros Roussos

Subject: Social Sciences, Psychology Keywords: Fear of missing out; FoMO; social media; Social networking sites; addiction; depression; anxiety; sleep; exercise

Online: 29 April 2022 (13:50:46 CEST)

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Working Paper ARTICLE

Depression in Bolivian Adults During COVID 19 Social Confinement: Moderating Effects of Resilience and Self-Efficacy

Eric Roth, Gustavo Choque, M. Fernanda García, Andrés Villalobos

Subject: Social Sciences, Psychology Keywords: Depression by confinement; COVID 19; Bolivia; perceived loneliness; anxiety; moderation effects

Online: 2 April 2021 (18:47:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0217.v1

An Overview of Mental Health During the COVID-19 Pandemic

Patrick Chen, Yanna Pusica, Dorsa Sohaei, Ioannis Prassas, Eleftherios Diamandis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; pandemic; mental health; psychological health; anxiety; suicide

Online: 8 March 2021 (13:32:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0194.v1

From Recession to Depression? Prevalence and Correlates of Depression, Anxiety, Traumatic Stress and Burnout in Healthcare Workers During the COVID-19 Pandemic in Greece: A Multi-Center, Cross-Sectional Study

Sofia Pappa, Nikolaos Athanasiou, Nikolaos Sakkas, Stavros Patrinos, Elpitha Sakka, Zafeiria Barmparessou, Stamatoula Tsikrika, Andreas Adraktas, Athanasia Pataka, Ilias Migdalis, Sofia Gida, Paraskevi Katsaounou

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; health care workers; Greece; mental health; depression; anxiety; traumatic stress; burnout

Online: 8 February 2021 (11:41:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0098.v2

Prevalence of Mental Disorders and Addictions among the Homeless Population in the Greater Paris Area, France

Anne Laporte, Stéphanie Vandentorren, Marc-Antoine Détrez, Caroline Douay, Yann Le Strat, Erwan Le Mener, Pierre Chauvin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: homeless; mental health; epidemiology; psychotic disorders; anxiety; mood disorders; alcohol

Online: 16 January 2018 (13:12:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0207.v1

The Prevalence and Sociodemographic Correlates of Social phobia in Oman: Online National Survey

Aamal Ambusaidi, Salim Al Huseini, Hiba Alshaqsi, Manal AlGhafri, Moon-Fai Chan, Nasser Al-Sibani, Samir Al-Adawi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Social Anxiety Disorder; Social Phobia, Online Survey; Adult, Oman; Liebowitz Social Anxiety Scale

Online: 8 August 2020 (09:39:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0091.v1

Tired, Worried and Burned Out But Still Resilient: A Cross-Sectional Study of Mental Health Workers During the Covid-19 Pandemic

Sofia Pappa, Joshua Barnett, Ines Berges, Nikolaos Sakkas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; healthcare workers; United Kingdom; mental health; burnout; resilience; insomnia; depression; anxiety; lifestyle

Online: 5 April 2021 (10:24:40 CEST)

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The burden of COVID-19 pandemic on health systems and the physical and mental health of healthcare workers (HCWs) has been substantial. This cross-sectional study aims to assess the effects of Covid-19 on the psychological wellbeing of mental health workers who provide care to a vulnerable patient population that have been particularly affected during this crisis. A total of 387 HCWs from across a large urban mental health service completed a self-administered questionnaire consisting of socio-demographic, lifestyle and work-based information and validated psychometric scales. Depression and anxiety were measured using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Scale (GAD-7) respectively, sleep problems with the Athens Insomnia Scale (AIS), burnout with the Maslach Burnout Inventory (MBI) and resilience with the Resilience Scale-14 (RS-14). Multivariable logistic regression analysis was performed to determine potential mediating factors. Prevalence of burnout was notable, with 52% recording moderate/severe in Emotional Exhaustion, 19.5% moderate/severe in Depersonalisation and 55.5% low/moderate Personal Accomplishment. Over half of all respondents (52%) experienced sleep problems; the presence of depressive symptoms was a significant predictor of insomnia. An increase in potentially harmful lifestyle changes, such as smoking, alcohol consumption and over-eating was also observed. However, high Resilience was reported by 70% of the sample and the importance of this is highlighted. Female gender was associated with increased levels of depression and emotional exhaustion while those with a history of mental health conditions were most at risk of affective symptoms, insomnia and burnout. Overall, our study revealed considerable levels of psychological distress and maladaptive coping strategies but also resilience and satisfaction with organizational support provided. Findings can inform tailored interventions in order to mitigate vulnerability and prevent long-term psychological sequelae.

Preprint REVIEW | doi:10.20944/preprints201806.0054.v1

Neuropsychiatric Borreliosis/Tick-Borne Disease: An Overview

Robert C Bransfield

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Lyme disease; Borrelia burgdorferi; tickborne diseases; persistent infection; treatment; assessment; depression; anxiety; sleep disorders; opioid addiction

Online: 5 June 2018 (08:33:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0267.v1

A single-case design investigation for measuring the efficacy of Gestalt therapy to treat depression in older adults with dementia in Italy and in Mexico: a research protocol

Alessandra Merizzi, Rosanna Biasi, José Fernando Álvarez Zamudio, Margherita Spagnuolo Lobb, Sara Santini

Subject: Social Sciences, Psychology Keywords: Gestalt therapy; dementia; depression; single-case experimental design; psychosocial interventions

Online: 19 January 2022 (09:32:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0079.v1

Nightmares in Children with FASD, ASD and Their Typically Developing Peers

Rabya Mughal, Siu Sing Wong, Dagmara Dimitriou, Elizabeth Halstead

Subject: Social Sciences, Psychology Keywords: autism; sleep; fetal alcohol spectrum disorders; nightmares; anxiety; executive function; behaviour

Online: 3 August 2021 (13:07:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0219.v1

Analysis of the Uncertainty in the relationship between Self-Determined Motivation and competitive Anxiety in dual-career students: Application of Information Theory and Bayesian Networks

Xavier Ponseti, Pedro L. Almeida, Joao Lameiras, Bruno Martins, Aurelio Olmedilla-Zafra, Jeannete López-Walle, Alexandre García-Mas

Subject: Social Sciences, Psychology Keywords: Bayesian networks; self determined motivation; competitive anxiety; Entropy reduction.

Online: 10 October 2018 (11:48:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0623.v1

The Reification of the Clinical Diagnosis of Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS) as an Immune and Oxidative Stress Disorder: Construction of a Data-Driven Nomothethic Network and Exposure of ME/CFS Subgroups

Michael Maes, Marta Kubera, Kristina Stoyanova, Jean–Claude Leunis

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: depression; neuroimmune; inflammation; oxidative and nitrosative stress; autoimmune; bacterial translocation

Online: 29 January 2021 (13:17:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202106.0362.v1

Intersections between Pneumonia, Lowered Oxygen Saturation Percentage and Immune Activation Mediate Depression, Anxiety and Chronic Fatigue Syndrome-like Symptoms due to COVID-19: A Nomothetic Network Approach

Hawraa Al-Jassas, Hussein Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: COVID-19; depression; chronic fatigue syndrome; inflammation; neuro-immune; psychiatry

Online: 14 June 2021 (13:01:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0631.v1

Proposed Model and Approach to Graduate Mentorship and Supervision During COVID-19

Carol Nash

Subject: Social Sciences, Education Keywords: COVID-19; graduate students; anxiety; depression; mentorship; supervision; narrative research

Online: 29 January 2021 (15:20:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0106.v1

Physical Activity, Mental Health and Wellbeing During the first COVID-19 Containment in New Zealand: A Cross-sectional Study

Wendy J O’Brien, Claire E Badenhorst, Nick Draper, Arindam Basu, Catherine A Elliot, Michael J Hamlin, John Batten, Danielle Lambrick, James Faulkner

Subject: Social Sciences, Psychology Keywords: Coronavirus; pandemic; exercise; depression; anxiety; wellness; physical distancing; lifestyle behavior change

Online: 5 July 2021 (15:27:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0636.v1

Analysis of Stress, Anxiety and Depression of Children During COVID-19

Samir Bandyopadhyay, Shawni Dutta

Subject: Medicine And Pharmacology, Tropical Medicine Keywords: COVID-19; stress; mental anxiety; depression; children and attributes

Online: 28 August 2020 (11:27:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0707.v1

Comparative Study of the Restorative Effects of Forest and Urban Videos during Covid-19 Lockdown: Intrinsic and Benchmark Value

Federica Zabini, Lorenzo Albanese, Francesco Riccardo Becheri, Gioele Gavazzi, Fiorenza Giganti, Fabio Giovanelli, Giorgio Gronchi, Andrea Guazzini, Marco Laurino, Qing Li, Tessa Marzi, Francesca Mastorci, Francesco Meneguzzo, Stefania Righi, Maria Pia Viggiano

Subject: Social Sciences, Cognitive Science Keywords: Anxiety; Audio-Visual stimulation; COVID-19; Environmental enrichment; Forest environments; Forest therapy; Lockdown; Mental health; Stress; Quarantine

Online: 31 August 2020 (05:20:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0149.v1

The Relationships between Smartphone Addiction of Middle School Students and Smartphone Usage Types, Depression, ADHD, Stress, Interpersonal Problems, and Parenting Attitude

Youl Pyo Hong, Yeon Ok Yeom, Myung Ho Lim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Smartphone Addiction; Middle School Students; Smartphone Usage Types; Depression; Parenting Attitude

Online: 6 September 2020 (16:27:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0058.v1

From "Leaky Gut" to Impaired Glia-neuron Communication in Depression

Leszek Rudzki, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; leaky gut; microbiota; cytokines; neuroimmunomodulation; oxidative stress; glia; blood-brain barrier; LPS; TLR

Online: 5 June 2020 (15:06:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0216.v1

Development of the Mental Synthesis Evaluation Checklist (MSEC): A Parent-Report Tool for Mental Synthesis Ability Assessment in Children with Language Delay

Julia Braverman, Rita Dunn, Andrey Vyshedskiy

Subject: Social Sciences, Psychology Keywords: autism, ASD, psychological evaluations, ATEC, Autism Treatment Evaluation Checklist, MSEC, language delay, developmental disorder, language therapy

Online: 16 April 2018 (16:27:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0260.v1

Role of Responsible Leadership for Organizational Citizenship Behavior for the Environment in Light of Psychological Ownership and Employee Environmental Commitment: A Moderated Mediation Model

Ali Abbas, Bilal Bilal, Ye Chengang, Shahid Manzoor, Irfan Ullah, Hafiz Muhammad Arslan

Subject: Social Sciences, Anthropology Keywords: Responsible leadership; Psychological ownership; Employee environmental commitment; Organizational citizenship behavior for the environment; China.

Online: 12 May 2021 (09:47:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201903.0105.v1

Upregulation of the Nitrosylome in Bipolar Disorder Type 1 (BP1), but not BP2, and Major Depression: Increased IgM Antibodies to Nitrosylated Conjugates are Associated with Indicants of Leaky Gut

Michael Maes, Denitsa Simeonova, Drozdstoy Stoyanov, Jean–Claude Leunis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression, bipolar disorder, oxidative and nitrosative stress, neuro-immune, inflammation, cytokines

Online: 8 March 2019 (09:13:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202204.0012.v1

Sexuality and Well-Being of Pakistani-Descent Female Adolescents Living in Canada: Perceptions and Recommendations

Neelam Punjani, Saima Hirani, Zubia Mumtaz, Margot Jackson, Elisavet Papathanassoglou, Kathy Hegadoren

Subject: Social Sciences, Sociology Keywords: Adolescent girls; Immigrant; Sexuality; Girls Voices; Well-being; Psychological Health; Pakistani

Online: 4 April 2022 (10:30:02 CEST)

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The sexual health needs of female immigrant adolescents in Canada have been largely unmet and have increased in magnitude over the last few years. Evidence suggests that immigrant adolescents lack sexual and reproductive health knowledge and use fewer sexual health-related services and sex education resources than do non-immigrant youth. In Pakistani immigrant adolescents, this difference appears to be associated with socio-cultural and religious practices. This paper aims to describe how first-or-second generation Pakistani-descent female adolescents, living in Canada, describe their perspectives on developing sexuality and well-being. In addition, this paper explicates female adolescents’ perceptions of their needs to support their sexuality while going through the adolescence stage. Using a qualitative interpretive descriptive design, individual interviews were conducted in combination with drawing timelines. A purposive sample of 21 female adolescents who were first- or second-generation Pakistani-descent was obtained. A thematic analysis approach was used for data analysis. Findings suggest that immigrant female adolescents encounter mental health concerns as a result of confusing messages they received from their parents related to sexuality. Also, discrimination, exclusion from sex education classes, and lack of knowledge on sexual health can result in social exclusion, avoidance of health care, and poor mental health outcomes such as depression and anxiety. These participants related experiences are potentially contributed by the lack of communication with parents about sexuality and lack of health care providers who can understand and speak to their needs and realities as immigrant individuals. Female adolescents expressed their need to break the silence around the topic of sexuality, to have a non-judgemental and blame-free attitude from adults, and for open, honest, and stigma-free conversations. This study provides preliminary qualitative evidence of the interplay between experiences of developing sexuality and overall well-being, particularly psychological wellbeing in female adolescent immigrants. It is crucial to involve, listen to, and incorporate adolescent girls’ voices when planning and implementing interventions to support healthy sexuality among immigrant adolescents.

Preprint REVIEW | doi:10.20944/preprints202103.0740.v1

Neurobehavioral Alterations in Occupational Noise Exposure: A Systematic Review

Veronica Traversini, Nicola Mucci, Lucrezia Ginevra Lulli, Eleonora Tommasi, Luigi Vimercati, Raymond Paul Galea, Simone De Sio, Giulio Arcangeli

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: occupational noise; job; work; behavioral disorders; psychological disorders; annoyance; occupational medicine; prevention.

Online: 30 March 2021 (13:39:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0135.v1

Lowered Zinc and Copper Levels in Drug-Naïve patients with Major Depression: Effects of Antidepressants, Ketoprofen and Immune Activation

Ahmed Jasim Twayej , Hussein Al-Hakeim, Arafat Hussein Al-Dujaili , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Depression, inflammation, neuro-immune, interleukins, ketoprofen, zinc

Online: 14 January 2019 (11:47:42 CET)

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There is now evidence that major depression is accompanied by lowered serum zinc, an immune-inflammatory biomarker. However, the effect of anti-inflammatory drugs as adjuvant to antidepressants on serum zinc and copper in relation to pro- and anti-inflammatory cytokines are not studied. The aim of the present work is to examine the effects of treatment with sertraline with and without ketoprofen on serum levels of zinc and copper in association with immune-inflammatory biomarkers in drug-naïve major depressed patients. We measured serum zinc and copper, interleukin (IL)-1β, IL-4, IL-6, IL-18, interferon (IFN)-γ, and transforming growth factor (TGF)-β1 in 40 controls and 133 depressed patients. The clinical efficacy of the treatment was measured using the Beck Depression Inventory-II (BDI-II) at baseline and 8 weeks later. In drug-naïve major depressed patients we found significantly reduced baseline levels of serum zinc and copper in association with upregulation of all cytokines, indicating activation of the immune-inflammatory responses system (IRS) as well as the compensatory immune regulatory system (CIRS). Treatment with sertraline significantly increased zinc and decreased copper levels, while ketoprofen did not have a significant add-on effect on zinc but attenuated the suppressant effects of sertraline on copper levels. During treatment, there was a significant inverse association between serum zinc and activation of the IRS/CIRS. The improvement in the BDI-II during treatment was significantly associated with increments in serum zinc coupled with attenuation of the IRS/CIRS. In conclusion, lower serum zinc is a hallmark of depression, while increments in serum zinc and attenuation of the immune-inflammatory response during treatment appear to play a role in the clinical efficacy of sertraline. Intertwined changes in zinc levels and the immune response play a role in the pathophysiology of major depression and participate in the mechanisms underpinning the clinical efficacy of antidepressants.

Preprint ARTICLE | doi:10.20944/preprints201812.0283.v1

Depression, Acculturative Stress and Social Connectedness among International University Students in Japan: prevalence and correlation.

Minh Hoang NGUYEN, Tam Tri LE, Serik MEIRMANOV

Subject: Social Sciences, Education Keywords: depression; acculturation stress; social connectedness; international students, university students, ASSIS, suicidal ideation

Online: 24 December 2018 (14:52:30 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0062.v1

Sickness Behaviour and Depression: An Updated Model of Peripheral-Central Immunity Interactions

Federico Turkheimer, Mattia Veronese, Valeria Mondelli, Diana Cash, Carmine Pariante

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Major depression; inflammation; sickness behaviour; mechanism; model; microglia; zcitokynes; CRP; blood brain barrier; choroid plexus

Online: 3 March 2022 (10:28:08 CET)

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Preprint REVIEW | doi:10.20944/preprints201906.0107.v1

Neuropharmacology of the neuropsychiatric symptoms of dementia: possible targets for novel therapeutic approaches

Damiana Scuteri, Laura Rombolà, Luigi Antonio Morrone, Giacinto Bagetta, Shinobu Sakurada, Tsukasa Sakurada, Paolo Tonin, Maria Tiziana Corasaniti

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: dementia, behavioural and psychological symptoms of dementia, neuropsychiatric symptoms, aromatherapy, bergamot essential oil.

Online: 12 June 2019 (15:33:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202107.0028.v2

Depression Diagnosis by Deep Learning Using EEG Signals: A Systematic Review

Atefeh Safayari, Hamidreza Bolhasani

Subject: Computer Science And Mathematics, Algebra And Number Theory Keywords: Deep Learning; Depression; Electroencephalogram; EEG; Depressive Disorders; Systematic Literature Review

Online: 10 November 2021 (15:29:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0236.v1

Total and Ionized Calcium and Magnesium Are Significantly Lowered in Drug-Naïve Depressed Patients: Effects of Antidepressants and Associations with Immune Activation

Arafat Hussein Al-Dujaili , Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; neuro-immune; cytokines; inflammation; indoleamine 2,3-dioxygenase

Online: 26 February 2019 (11:05:49 CET)

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Major depressive disorder (MDD) is associated with changes in the levels of the cations calcium (Ca) and magnesium (Mg) as well as circulating pro- and anti-inflammatory cytokines. The immune-inflammatory nature of MDD has encouraged researchers to use anti-inflammatory drugs as an adjuvant treatment for MDD. However, the effect of this treatment on cation levels has not been studied. The present study examined a) differences in both cations between drug-naïve MDD patients and controls, and b) the effects of a combination of sertraline and ketoprofen, an anti-inflammatory drug, on Ca and Mg (both total and ionized). In the same patients we also examined the associations between both cations and IL-1β, IL-4, IL-6, IL-18, IFN-γ, TGF-β1, zinc and indoleamine 2,3-dioxygenase (IDO). Clinical improvement was estimated using the Beck Depression Inventory-II (BDI-II) at baseline and after follow up for two months. Serum Ca and Mg (total and ionized) were significantly lower in MDD patients as compared with controls, while treatment significantly increased calcium but decreased magnesium levels. There were significant and inverse correlations between the BDI-II scores from baseline to endpoint and Ca (both total and ionized), but not Mg, levels. The effects of calcium on the BDI-II score remained significant after considering the effects of zinc, IDO and an immune activation z unit weighted composite score based on the sum of all cytokines. There was a significant and inverse association between this immune activation index and calcium levels from baseline to endpoint. In conclusion, reduced levels of both cations play a role in the pathophysiology of major depression. Increased calcium levels are coupled to the clinical efficacy of antidepressants and attenuation of immune activation. The suppressant effect of antidepressants on Mg levels may be a side effect of those drugs. New antidepressant treatments should be developed that increase the levels both Ca and Mg.

Preprint ARTICLE | doi:10.20944/preprints201808.0358.v1

Efficient delineation of nested depression hierarchy in digital elevation models for hydrological analysis using level-set method

Qiusheng Wu, Charles R. Lane, Lei Wang, Melanie K. Vanderhoof, Jay R. Christensen, Hongxing Liu

Subject: Environmental And Earth Sciences, Remote Sensing Keywords: depression filling; digital elevation models; hydrological analysis; level-set method; LiDAR; surface depressions

Online: 20 August 2018 (14:13:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202102.0460.v1

COVID-Well Study: Qualitative Evaluation of Supported Wellbeing Centres and Psychological First Aid for Healthcare Workers During the COVID-19 Pandemic

Holly Blake, Alisha Gupta, Mahnoor Javed, Ben Wood, Steph Knowles, Emma Coyne, Joanne Cooper

Subject: Social Sciences, Psychology Keywords: COVID-19; pandemic; psychological wellbeing; workforce; peer-to-peer support; psychological first aid; wellbeing

Online: 22 February 2021 (11:37:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201911.0368.v1

The Role of Perceived Social Support in the Psychological Well-Being of Young Offenders: from Pretrial Detention to Correctional Camps

Fedor Ushkov, Roman Shilko, Ludmila Shaigerova, Alexandra Dolgikh, Olga Almazova, Olga Vakhantseva, Yuri Zinchenko

Subject: Social Sciences, Psychology Keywords: psychological well-being; young offenders; social support; pretrial detention; correctional camps; positive and negative feelings; positive and negative affects

Online: 29 November 2019 (04:16:05 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0083.v1

Psychological Distress among Bangladeshi Dental Students during the COVID-19 Pandemic

Farah Sabrina, Mohammad Tawfique Hossain Chowdhury, Sujan Kanti Nath, Ashik Abdullah Imon, S M Abdul Quader, Md Shahed Jahan, Ashek Elahi Noor, Clopa Pina Podder, Unisha Gainju, Rina Niroula, Muhammad Aziz Rahman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Psychological distress; Fear; Coping; COVID-19; Bangladesh; Dental; Mental health

Online: 6 December 2021 (15:22:59 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201804.0299.v1

Psychological Pressure Distorts High Jumpers’ Perception of the Height of the Bar

Yoshifumi Tanaka, Joyo Sasaki, Kenta Karakida, Kana Goto, Yufu M. Tanaka, Takayuki Murayama

Subject: Social Sciences, Psychology Keywords: action-specific perception; dynamic perception; high jump; psychological stress

Online: 23 April 2018 (12:59:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0037.v1

Hygiene Behavior in Face of the Corona Pandemic: Compliance Rates and Associations With Fear, SARS-COV-2 risk, Mental Health and Disability

Sonia Lippke, Franziska M. Keller, Christina Derksen, Lukas Kötting, Alina Dahmen

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; disability; risk factors; communication; medical rehabilitation; psychosomatic patients; general public; infection; physical health; psychological health

Online: 2 September 2021 (12:08:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0086.v1

Continuous Health Promotion and Participatory Ergonomics in a Small Company

Nicola Magnavita

Subject: Public Health And Healthcare, Public, Environmental And Occupational Health Keywords: workplace; health promotion; work-related stress; anxiety; depression; participatory ergonomics; wellbeing; best practice; work organization

Online: 12 February 2018 (09:09:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0032.v1

Telecommuting, Off-Time Work, and Intrusive Leadership in Workers’ Well-Being

Nicola Magnavita, Giovanni Tripepi, Carlo Chiorri

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: smart work; psychosocial stressors; health promotion; work-related stress; Covid-19; anxiety; depression; happiness

Online: 1 March 2021 (14:43:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0201.v1

Mental Health, Greenness and Nature Related Behaviours in the Adult Population of Stockholm County during Covid-19-related Restrictions

Mare Lõhmus, Cecilia U. D. Stenfors, Tomas Lind, André Lauber, Antonios Georgelis

Subject: Social Sciences, Psychology Keywords: COVID-19; greenness; mental health; societal change; social isolation; psychological factors; resilience

Online: 5 March 2021 (21:37:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0593.v1

Neuroinflammatory Remodeling of the Anterior Cingulate Cortex as a Key Driver of Mood Disorders in Gastrointestinal Disease and Disorders

Chelsea Matisz, Aaron Gruber

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: gut inflammation; neuroinflammation; inflammatory bowel disease; Crohn’s disease; ulcerative colitis; irritable bowel syndrome; Celiac disease; functional dyspepsia; anterior cingulate cortex; microglia; sympathetic nervous system; mood disorders; depression; anxiety; cognition

Online: 25 September 2020 (03:45:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0664.v1

Assessment of the Psychological Impact and Perceived Stress Due to COVID-19 Lockdown in Young Adult Population of India.

Sreelakshmi M, Irfanul Haque, Sarita Jangra Bhyan, Ankit Gaur, Aashi Jain, Amrita Kumari, Besty Thomas, Nancy Goel, Rashi Chauhan

Subject: Social Sciences, Psychology Keywords: COVID-19 lockdown; psychological impact; perceived stresses-R scale; PSS scale; young adults

Online: 28 July 2020 (04:39:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0215.v1

Major Depressive Disorder is Associated with Impaired Mitochondrial Function in Skin Fibroblasts

Kerstin Kuffner, Julian Triebelhorn, Katrin Meindl, Christoph Benner, André Manook, Daniel Sudria, Ramona Siebert, Caroline Nothdurfter, Thomas C. Baghai, Konstantin Drexler, Mark Berneburg, Rainer Rupprecht, Vladimir M. Milenkovic, Christian H. Wetzel

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: major depression; skin fibroblasts; mitochondria; bioenergetics; oxidative phosphorylation; adenosine triphosphate; calcium imaging; mitochondrial membrane potential; mitochondrial DNA copy number

Online: 12 March 2020 (14:11:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0377.v1

Healthy Practice of Female Soccer and Futsal: Identifying Sources of Stress, Anxiety and Depression

Aurelio Olmedilla, Enrique Ortega, Francisco Javier Robles-Palazón, Miquel Salom, Alexandre García-Mas

Subject: Social Sciences, Psychology Keywords: psychological impact; sport injuries; gender

Online: 27 May 2018 (11:21:52 CEST)

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