This study employed 15 CMIP6 GCMs and evaluated their ability to simulate rainfall over Uganda during 1981-2019. The models and the ensemble mean were assessed based on the ability to reproduce the annual climatologyseasonal rainfall distribution, trend, and statistical metrics, including mean bias error, root mean square error, and pattern correlation coefficient. The Taylor diagram and Taylor skill score (TSS) were used in ranking the models. The models performance varies greatly from one season to the other. The models reproduced the observed bimodal rainfall pattern of March to May (MAM) and September to November (SON) rains occurring over the region. Some models slightly overestimated, while some slightly underestimated, the MAM rainfall. However, there was a high rainfall overestimation during SON by most models. The models showed a positive spatial correlation with observed dataset, whereas a low correlation was shown interannually. Some models could not capture the rainfall patterns around local-scale features, for example, around the Lake Victoria basin and mountainous areas. The best performing models identified in the study include GFDL-ESM4, BCC-CMC-MR, IPSL-CM6A-LR, CanESM5, GDFL-CM4-gr1, and GFDL-CM4-gr2. The models CNRM-CM6-1 and CNRM-ESM2 underestimated rainfall throughout the annual cycle and mean climatology. However, these two models better reproduced the spatial trends of rainfall during both MAM and SON. The model spread in CMIP6 over the study area calls for further investigation on the attributions and possible implementation of robust approaches of Machine learning to minimize the biases.

This paper presents an analysis of precipitation extremes over the East African region. The study employs six extreme precipitation indices defined by the Expert Team on Climate Change Detection and Indices (ETCCDI) to evaluate possible climate change. Observed datasets and CMIP6 simulations and projections are employed to assess the changes during the two main rainfall seasons of March to May (MAM) and October to December (OND). The study evaluated the capability of CMIP6 simulations in reproducing the observed extreme events during the period 1995 – 2014. Our results show that the multi-model ensemble (herein referred to as MME) of CMIP6 models can depict the observed spatial distribution of precipitation extremes for both seasons, albeit with some noticeable exceptions in some indices. Overall, MME's assessment yields considerable confidence in CMIP6 to be employed for the projection of extreme events over the study area. Analysis of extreme estimations shows an increase (decrease) in CDD (CWD) during 2081 – 2100 relative to the baseline period in both seasons. Moreover, SDII, R95p, R20mm, and PRCPTOT demonstrate significant OND estimates compared to the MAM season. The spatial variation for extreme incidences shows likely intensification over Uganda and most parts of Kenya, while reduction is observed over the Tanzania region. The increase in projected extremes during two main rainfall seasons poses a significant threat to the sustainability of societal infrastructure and ecosystem wellbeing. The results from these analyses present an opportunity to understand the emergence of extreme events and the capability of model outputs from CMIP6 in estimating the projected changes. More studies are encouraged to examine the underlying physical features modulating the occurrence of extremes incidences projected for relevant policies.

Presentation of case: A 20 year old men from Simanjiro district in northern Tanzania presented with a 3 year history of splenomegaly, fatigue, cachexia, skin maculae and recent onset of watery diarrhea at Kilimanjaro Christian Medical Centre (KCMC) in Northern Tanzania. Due to laboratory findings of pancytopenia, diagnostic workup included bone marrow aspiration cytology and biopsy. Although the rapid test (IT LEISH, rK39 RDT) was negative, blood smear showed amastigote forms of Leishmaniasis in macrophages. Repeat bone marrow aspiration and PCR eventually confirmed VL. The patient denied travel to known endemic areas of visceral leishmaniasis (VL). Treatment was initiated with Amphotericin B, but the patient died on the fourth day of treatment from respiratory insufficiency. An autopsy revealed massive organ manifestations of VL. Case discussion: This is the first reported autochthonous case of VL in Tanzania. Clark et al. detected the vector Phlebotomous martini in Northern Tanzania in 2013, in a region boardering the district of our patient. The negative rapid test draws attention to the fact that sensitivity and specificity was found to be low in East African VL patients as displayed earlier by a Kenyan study. Therefore, tissue samples (spleen or bone marrow) remain necessary for diagnosis. The variety of symptoms in this presented case was remarkable, including the occurrence of Post Kala Azar Dermal Leishmaniasis (PKDL) and VL at the same time. This has been described in East African VL cases before as well as the occurrence of chronic diarrhea. An elongated undiagnosed period likely led to a mixed clinical picture that included: hepato-splenomegaly, PKDL, cachexia, and diarrhea.

This study examines the improvement in coupled intercomparison project phase six (CMIP6) models against the predecessor CMIP5 in simulating mean and extreme precipitation over the East Africa region. The study compares the climatology of the precipitation indices simulated by the CMIP models with the CHIRPS dataset using robust statistical techniques for 1981 – 2005. The results display the varying performance of the general circulation models (GCMs) in the simulation of annual and seasonal precipitation climatology over the study domain. CMIP6-MME shows improved performance in the local annual mean cycle simulation with a better representation of two peaks, especially the MAM rainfall relative to its predecessor. Moreover, simulation of extreme indices is well captured in CMIP6 models relative to its predecessor. The CMIP6-MME performed better than the CMIP5-MME with lesser biases in simulating SDII, CDD, and R20mm over East Africa. Remarkably, most CMIP6 models are unable to simulate extremely wet days (R95p). A few CMIP6 models (e.g., NorESM2-MM and CNRM-CM6-1) depicts robust performance in reproducing the observed indices across all analyses. Conversely, OND season shows the overestimation of some indices (i.e., R95p, PRCPTOT), except for SDII, CDD, and R20mm. Consistent with other studies, the mean ensemble performance for both CMIP5/6 shows better performance due to the cancellation of some systematic errors in the individual models. Generally, the CMIP6 depicts improved performance in the simulation of MAM season akin CMIP5 models. However, the new model generation is still marred with uncertainty, thereby depicting substandard performance over the East Africa domain. This calls for further investigation of attribution studies into the sources of persistent systematic biases and a prerequisite for identifying individual models with robust features that can accurately simulate observed patterns for future usage.

This study evaluates the historical mean surface temperature (hereafter T2m) and examines how T2m changes over East Africa (EA) in the 21^st century using CMIP6 models. An evaluation was conducted based on mean state, trends, and statistical metrics (Bias, Correlation Coefficient, Root Mean Square Difference, and Taylor skill score). For future projections over EA, five best performing CMIP6 models (based on their performance ranking in historical mean temperature simulations) under the shared socioeconomic pathways SSP2-4.5 and SSP5-8.5 scenarios were employed. The historical simulations reveal an overestimation of the mean annual T2m cycle over the study region with fewer models depicting underestimations. Further, CMIP6 models reproduce the spatial and temporal trends within the observed range proximity. Overall, the best performing models are as follows: FGOALS-g3, HadGEM-GC31-LL, MPI-ESM2-LR, CNRM-CM6-1, and IPSL-CM6A-LR. During the three-time slice under consideration, the Multi Model Ensemble (MME) project many changes during the late period (2080 – 2100) with expected mean changes at 2.4 °C for SSP2-4.5 and 4.4 °C for the SSP5-8.5 scenario. The magnitude of change based on Sen’s slope estimator and Mann-Kendall test reveal significant increasing tendencies with projections of 0.24°C decade-1 (0.65°C decade-1) under SSP2-4.5 (SSP5-8.5) scenarios. The findings from this study illustrate higher warming in the latest model outputs of CMIP6 relative to its predecessor, despite identical instantaneous radiative forcing.

The increasing cancer burden is a major health concern in Arab countries with variations in cancer profiles. Given the limited oncology research output and scarce data on cancer trial participation in the Arab region, this study explored the therapeutic cancer trial landscape in Arab countries over the past 20 years. A bibliometric analysis of the PubMed database was conducted on primary publications of therapeutic trials with a participating Arab center. Arab countries participated in 320 published cancer-related therapeutic trials (2000‒2021). There was a consistent increase in the number of trials, sample size, multiregional site participation, and number of randomized trials. However, most trials were small, did not receive external funding, and included a single Arab site. Compared with Arab-only trials, trials with joint non-Arab sites were larger (p = .003) and more likely to be externally funded (p < .001). Citation numbers and journal impact factors were higher in trial publications with joint non-Arab authorship than those without (p < .001, for both). Despite improving conduct and publication records of oncology trials with Arab centers, cancer trial participation remains limited in Arab countries. Concerted efforts are required to encourage sponsorship and international collaboration in this region.

In late/early 2019/2020, unprecedented high-water-levels were observed in Lake Victoria causing massive flooding in the low-lying lake-adjacent areas and disrupting human and natural systems in the Lake Victoria Basin (LVB). The high lake water-level coincided with unusually heavy and prolonged 2019 June to December precipitation in the LVB. The current study estimates future precipitation patterns over the LVB using HighResMIP and ScenarioMIP general circulation model (GCM) simulations from the 6^th phase of the Coupled Model Intercomparison Project (CMIP6). Results show that HighResMIP and ScenarioMIP simulations can adequately reproduce LVB’s precipitation patterns – albeit with location-specific biases. Generally, the GCM simulations tend to over-estimate precipitation patterns over Lake Victoria while under-estimating precipitation patterns over the lake-adjacent areas. Projections show significant future precipitation changes over the LVB relative to the 1970-1999 baseline, with more pronounced changes over the lake than in lake-adjacent areas. Overall, mean annual precipitation is projected to increase by about 18% and 31% by the end of the century, under SSP2-4.5 and SSP5-8.5 scenarios, respectively. Additionally, mean daily precipitation intensity (SDII) is projected to increase by up-to 14% while the maximum 5-day precipitation values (RX5Day) increase by up-to 71% under the SSP5-8.5 scenario. Heavy precipitation events, represented by the width of the right tail distribution of precipitation (99p-90p), are projected to increase by 50% and 94% under SSP2-4.5 and SSP5-8.5, respectively. Given that direct precipitation accounts for about 80% of Lake Victoria’s water budget, the lake’s future water-level fluctuations are likely to be more rampant and unpredictable under the changing climate. Hence, enhanced production and use of climate services is recommended to minimize the risk posed by potentially high water-level fluctuations in Lake Victoria and, ultimately, enhance the socio-economic safety of communities in the LVB.

Electric mobility begins to enter East-African markets. This paper aims to investigate what policy level solutions and stakeholder constellations are established in the context of e-mobility in Dar es Salaam, Kigali, Kisumu and Nairobi and in which ways they attempt to tackle implementation of electric mobility solutions. The study employs two key methods including content analysis of policy and programmatic documents as well as interviews based on purposive sampling ap-proach with stakeholders involved in mobility transitions. The study findings point out that transport operators and their representative associations are less recognized as major players in the transition, far behind new e-mobility players (start-ups) and public authorities. The study further indicates that a set of financial and technical barriers persist such as high upfront invest-ment costs in vehicles and infrastructure, or anxieties regarding competitiveness with fossil fuel vehicles, that constrain the uptake of such private e-mobility initiatives. This study concludes by identifying current gaps that need to be tackled by policy makers and stakeholders in order to implement inclusive electric mobility in East-African cities, considering modalities that include transport providers and address their financial constraints.

Turkey is located in the heart of complex transition geography between Eurasia and the Middle East. In the grand scheme, the so-called Eastern Mediterranean Basin is almost amidst the dusty belt and a hot spot of climate change. The downstream location of dust carrying winds from the closer desert sources reveals Turkey as an open plane to particulate matter exposure throughout the year. In order to clarify this phenomenon, it is aimed to find out the desert dust climatology of Turkey via CALIPSO onboard Lidar. This prominent instrument enables us to understand clouds, aerosols and their types and relatedly climatic systems with its valuable products. In this study, 9-year CALIPSO derived pure dust product is formed to explain horizontal and vertical distributions, transport heights and case incidences. Results indicated mass and conditional abundancy are higher with the location shifts from west to east. In the same direction, dominant spring months change to summer and autumn. Mountain range systems surrounding Anatolia are the main obstacles against lofted and buoyant dust particles travelling to northern latitudes. Even if high ridges accumulate mass load on the southern slopes, it also enables elevated particles to reach the ground level of the inner cities.

Accurate and consistent rainfall observations are vital for climatological studies in support of better planning and decision making. However, estimation of accurate spatial rainfall is limited by sparse rain gauge distributions. Satellite rainfall products can thus potentially play a role in spatial rainfall estimation but their skill and uncertainties need to be under-stood across spatial-time scales. This study aimed at assessing the temporal and spatial performance of seven satellite products (TARCAT (Tropical Applications of Meteorology using SATellite and ground-based observations (TAMSAT) African Rainfall Climatology And Time series), Climate Hazards Group InfraRed Precipitation with Station data (CHIRPS), Tropical Rainfall Measuring Mission (TRMM-3B43), Climate Prediction Center (CPC) Morphing (CMORPH), the Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks- Climate Data Record (PERSIANN-CDR), CPC Merged Analysis of Precipitation (CMAP) and Global Precipitation Climatology Project (GPCP) using gridded (0.05o) rainfall data over East Africa for 15 years(1998-2012). The products’ error distributions were qualitatively compared with large scale horizontal winds (850 mb) and elevation patterns with respect to corresponding rain gauge data for each month during the ‘long’ (March-May) and ‘short’ (October-December) rainfall seasons. For validation only rainfall means extracted from 284 rain gauge stations were used, from which qualitative analysis using continuous statistics of Root Mean Squared Difference, Standard deviations, Correlations, coefficient of determinations (from scatter plots) were used to evaluate the products’ performance. Results revealed rainfall variability dependence on wind flows and modulated by topographic influences. The products’ errors showed seasonality and dependent on rainfall intensity and topography. Single sensor and coarse resolution products showed lowest performance on high ground areas. All the products showed low skills in retrieving rainfall during ‘short’ rainfall season when orographic processes were dominant. CHIRPS, CMORPH and TRMM performed well, with TRMM showing the best performance in both seasons. There is need to reduce products’ errors before applications.

Morphological study of lakes defines the sensitivity of their watershed. Moreover, it plays important role in safeguarding the lake’s ecosystem services through proper planning and utilization of the lakes’ resources. In the last few decades, the morphology of lakes in Ethiopian and Kenyan Rift (EKR) valley are experiencing contradicting morphological changes. Being in the same system, some are shrinking and others are expanding beyond their natural boundaries. The objective of this review is to shed light on the trends in spatio-temporal water level fluctuation and their contributing factors for lakes to the academia and decision makers. Peer reviewed article journals, conference proceedings, thesis, and book chapters collected from online sources and supplied by authors on request formed a database of 346 documents where 226 are critically assessed. The review indicated that lakes in Ethiopian rift are shrinking and expanding, while Kenyan lakes are expanding. The en-dorheic lakes suffered the most fluctuations due to anthropogenic factors at the expense of loss of forest and woodlands in their watershed. While the lakes’ water quality related to the morphological changes are given less attention, the predicted 12 m drop of Lake Turkana due to projects in the Omo catchment did not materialize.

Advances in remote sensing have led to use of satellite-derived rainfall products to complement the sparse rain gauge data. Although globally derived and some regional bias corrected, these products often show large discrepancies with ground measurements attributed to local and external factors that require systematic consideration. Decreasing rain gauge network however inhibits continuous validation of these products. We propose to deal with this problem by the use of Bayesian approach to merge the existing historical rain gauge information to create a consistent satellite rainfall data that can be used for climate studies. Monthly Bayesian bias correction is applied to the Climate Hazards Group Infrared Precipitation with Stations (CHIRPS v2) data to reduce systematic errors using a corresponding gridded (0.05°) rain gauge data over East Africa for a period of 33 (1981–2013) years of which 22 years are utilized to derive error fields which are then applied to an independent CHIRPS data for 11 years for validation. The bias correction is spatially and temporally assessed during the rainfall wet months of March-May (MAM), June-August (JJA) and October–December (OND) in East Africa. Results show significant reduction of systematic errors at both monthly and yearly scales and harmonization of their cumulative distributions. Monthly statistics showed a reduction of RMSD (29–56)% and MAE (28–60)% and an increase of correlations (2–32) %, while yearly ones showed reductions of RMSD (9-23)%, and MAE (7–27)% and increase of correlations (4–77)% for MAM months, reduction of RMSD (15–35)% and MAE (16–41)% and increase in correlations (5–16)% for JJA months, and reduction of RMSD (3–35)% and MAE (9–32)% and increase of correlations (3–65)% for OND months. Systematic errors of corrected data were influenced by local processes especially over Lake Victoria and high elevated areas. Large-scale circulations induced errors were mainly during JJA and OND rainfall seasons and were reduced by the separation of anomalous years during training. The proposed approach is recommended for generating long-term data for climate studies where consistencies of errors can be assumed.

Astroviruses (AstVs) are occurs globally and are common causes of gastroenteritis in human and animals. The genetic diversity and epidemiology of AstVs in Africa is not well known, hence, we aimed to genetically characterize astroviruses in asymptomatic smallholder piglets in East Africa. Twenty-four samples randomly selected from 446 piglets (<6 months old), initially collected for rotavirus study, was sequenced for metagenomic analysis. Thirteen (13/24) samples had contigs with high identity to genus Mamastrovirus. Analysis of 7 strains with complete (or near complete) genome revealed variable nucleotide and amino acid sequence identities with known PoAstV strains. The U083 and K321 strains had nucleotide sequence similarities ranging from 66.4 to 75.4 % to the known PoAstV2 strains, nucleotide sequence similarity of U460 strain with known PoAstV3 ranged 57.0 to 65.1 % to the, while K062, K366, K451, and K456 strains showed nucleotide sequence similarities of 63.5 to 80 % to the known PoAstV4 strains. The low sequence identities (<90 %) indicate that novel genotypes of PoAstVs are circulating in the study area. Multiple recombination events were detected in our PoAstV4 strains, indicating that the genetic diversity observed in these strains may be due to recombination. Importantly, we identified potential candidate epitopes with conserved peptides in our PoAstV strains that could aid in the design of immune diagnosis tools and subunit vaccines. Our data provide new intuitions into the genetic structure of porcine astroviruses in East African.

: The ichthyofauna of Lake Tanganyika consists of 12 families of fish of which five belong to Siluriformes (catfishes). Studies on siluriforms and their parasites in this lake are very fragmentary. The present study was carried out to help fill the knowledge gap on the monogeneans parasitizing the siluriform fishes of Lake Tanganyika in general and more particularly Clarias gariepinus. The gills of a specimen of Clarias gariepinus (Clariidae) were examined for ectoparasites. We identified the monogenean Gyrodactylus transvaalensis (Gyrodactylidae). This is the first time this parasite was found infecting gills. We are the first to observe a large spine in the male copulatory organ of this species, and to provide measurements of its genital spines; this completes the description of the male copulatory organ which is important in standard monogenean identification. This is the first monogenean species reported on C. gariepinus at Lake Tanganyika and the third known species on a representative of Siluriformes of this lake. It brings the total number of species of Gyrodactylus recorded in Lake Tanganyika to four. Knowing that other locations where this species has been reported are geographically remote from Lake Tanganyika, we propose a “failure to diverge” phenomenon for G. transvaalensis.

Emerging pollutants pose significant threats to Uganda's ecosystems and public health amidst rapid urbanization, industrial growth, and intensified agriculture. This systematic review comprehensively assessed these pollutants by analyzing existing Ugandan literature and research studies, revealing various types in different environmental compartments. These pollutants, including pharmaceuticals, personal care products, pesticides, industrial chemicals, heavy metals, radionuclides, biotoxins, disinfection byproducts, hydrocarbons, and microplastics, originate from urban, industrial, and agricultural regions. Wastewater and improper waste disposal are major contributors. From an initial search of 794 articles across multiple databases such as PubMed, African Journal Online (AJOL), Web of Science, Science Direct, and Google Scholar, 138 were found relevant. The review underscores potential ecological and health impacts, including antibiotic resistance, endocrine disruption, and carcinogenicity. Existing monitoring and regulation efforts are discussed, alongside the need for specific regulations, improved data collection, and public awareness campaigns. Recommendations include advanced wastewater treatment, sustainable agriculture, and source control measures. Emphasis is placed on further research to address knowledge gaps and develop effective policies and interventions. Uganda can mitigate these risks by implementing comprehensive monitoring, robust regulations, and sustainable practices, safeguarding the environment and public health.

Although numerous articles have been published to address drivers or barriers of corporate social responsibility (CSR), some parts of the world have received less attention. In this study, I reviewed the literature, from 2010 to 2021, to identify drivers and barriers of CSR in the the Middle East and North Africa (MENA) region and compare them with the findings in western countries. (2) Methods: For this study, I used a structured literature review method. By setting the inclusion and exclusion criteria, only 28 articles remained from selected database; (3) Results: The findings revealed some CSR drivers, such as leadership styles, profitability, reputation, moral commitment, and environmental conservation are common in both regions. There are also some differences between CSR drivers, for example religious beliefs, low concentration of ownership, and company characteristics are some of the drivers in the MENA region. Maintaining social license to operate, avoiding the risks of community opposition, pressure from the government, and consumer demand tend to be more important in western countries. Common barriers in both regions are lack of financial resources, cost, lack of CSR knowledge and awareness, and ownership concentration. This review also highlighted that lack of law enforcement, lack of stakeholder communication, lack of management commitment, lack of interests, corruption, and financial debts are some of the addressed barriers of CSR in the MENA region, while cost/benefit ratio, lack of customer interest, and lack of scientific frameworks are the special barriers in western countries. (4) Conclusions: While researchers in western countries have more focus on energy sector, there is a lack of research about drivers and barriers of CSR in the MENA region in several industries, including oil and gas.

Purpose: This study aimed to describe the molecular epidemiology and seasonality of human rhinovirus (HRV) in chronic obstructive pulmonary disease (COPD) and its association with COPD exacerbations in Abu Dhabi, the United Arab Emirates (UAE). Methods: Sputum specimens were collected for analysis from all COPD patients who visited a medical center from November 2021 to October 2022. The real-time quantitative polymerase chain reaction (qPCR) test was used to detect HRV. Results: Of the 78 COPD patients included in the study, 58 (74%) pa-tients presented with one or more exacerbation episodes. The incidence of COPD exacerbation peaked over the winter and substantially decreased during the summer. HRV positivity in pa-tients during exacerbation (E1) was 11/58 (19%) and 15/58 (26%) two weeks after the exacerbation episode (E2). There was no significant difference in the HRV load in these patients. No statistically significant difference was observed in the detection of HRV during exacerbation compared to patients with stable COPD. Conclusion: This is the first study to assess the association between HRV detection by qPCR and COPD exacerbations in the UAE. The high sensitivity of the detec-tion technology helped collect reliable epidemiologic data. Few studies have provided similar Middle East data. This study's pattern of COPD exacerbations and HRV detection parallels that of temperate countries. This information can help with future, more extensive surveillance of res-piratory viruses in the UAE and the Middle East and their association with COPD exacerbations.

In modern times like today, technology and science are developing very fast. This has resulted in a condition known as globalization. This era has had a significant impact on every country globally, including in Indonesia, such as the spread of culture is solid. This flow has many benefits and advantages. However, this globalization can also have a negative impact. One of them is the erosion of native Indonesian culture compared to foreign cultures. Therefore, this research to find the origin, causes, and impacts of the influx of cultural globalization on the current culture of East Java because it is the province of origin of the researchers. Here the researchers asks about the impact of this modern culture and how influential culture is to the people of East Java. The method used by the researchers in making this paper is Literature Review using qualitative descriptive writing with quantitative data. The researchers findings as material in this paper amounted to 24 materials with the provisions of 20 journal article materials, 2 article materials online provided that they were published in the last three years, and 2 E-books for methods on this paper. This study's boundaries are a modern culture that the researchers takes about western culture (western) and South Korean culture (Hallyu). In addition, this study only discusses cultures originating in East Java, such as Javanese.

Earth Observation (EO) techniques have significantly evolved over time, covering a wide range of applications in different domains. The scope of this study is to review the research conducted on EO in the Eastern Mediterranean, Middle East, and North Africa (EMMENA) region and to identify the main knowledge gaps. We searched through the Web of Science database for papers published between 2018 and 2022 for EO studies in the EMMENA. We categorized the papers in the following thematic areas: Atmosphere, Water, Agriculture, Land, Disaster Risk Reduction (DRR), Cultural Heritage, Energy, Marine Safety and Security (MSS) and Big Earth Data (BED); 6647 papers were found with the highest number of publications in the thematic areas of BED (27%) and Land (22%). Most of the EMMENA countries are surrounded by sea, yet there was a very small number of studies on MSS (0.9% of total number of papers). This study detected a gap in fundamental research in the BED thematic area. Other future needs identified by this study are the limited availability of very high resolution and near real time remote sensing data, the lack of harmonized methodologies and the need for further development of models, algorithms, early warning systems and services.

The Indian Himalayan Region (IHR), due to its topography, geography, and active tectonics, a rough mountain zone, is among the most vulnerable zones to the landslip danger. The most cutting-edge and accurate ways for creating a landslip susceptibility model (LSM) are advanced statistical techniques. The goal of the current work was to use advanced statistical techniques to analyse and evaluate the updated landslip susceptibility for East District in the NE Himalayas of Sikkim, India. The spatiotemporal landslip inventory for the years are produced using literature surveys, historical satellite imageries and on-site observations. Slope, aspect, elevation, curvature, plane curvature, profile curvature, topographic wetness index (TWI), lithology, distance to faults, distance to streams, distance to roads, normalised difference vegetation index (NDVI), rainfall, drainage density and land use/ land cover (LULC) are some of the topographic, environmental, geologic, and anthropogenic factors that were included in the spatial database. These LCFs were chosen to study the area's periodic landslip vulnerability. An inventory of 151 landslides from historical published records, field visits and Imagery interpretations, respectively, were used in the experimental design. Information Value Model (IVM), was used to evaluate the vulnerability to landslides as determined by fifteen LCFs. The goal of the study is to reduce the number of fatalities and possible economic harm caused by the region's frequent slope instabilities. It is expected that the application of statistical algorithms would assist relevant authorities and organisations in properly planning for and managing the region's landslip threat.

East Lake in Wuhan, China, harbors a high number of freshwater fish species of great conservation value, concurrently serving as vital resources for local livelihoods. However, the ecosystem is threatened by an array of anthropogenic activities, thus requiring consistent monitoring of the local fish community to enable more efficacious conservation management. In place of conventional surveying methods, we undertook the first analysis of the fish distribution within East Lake via metabarcoding of environmental DNA (eDNA). The accuracy and efficacy of eDNA metabarcoding relies heavily upon selecting an appropriate primer set for PCR amplification. Given the varying environmental conditions and taxonomic diversity across distinct study systems, it remains a challenge to propose an optimal genetic marker for universal use. Thus, it becomes necessary to select PCR primers suitable for the composition of fish in the East Lake. Here, we evaluated the performance of two primer sets, Mifish-U and Metafish, designed to amplify 12S rRNA barcoding genes in fishes. Our results detected a total of 116 taxonomic units and 51 fish species, with beta diversity analysis indicating significant differences in community structure diversity between the 6 sampling locations encompassing East Lake. While it was difficult to accurately compare the species-level discriminatory power and amplification bias of the two primers, Mifish outperformed Metafish in terms of taxonomic specificity for fish taxa and reproducibility. These findings will assist with primer selection for eDNA-based fish monitoring and biodiversity conservation in the East Lake and other freshwater ecosystems.

Here we describe the genome of an Echovirus 7 isolate of South-East Asian ancestry recovered from a child with acute flaccid paralysis (AFP) in Nigeria. The genome has 7,295nt and an open reading frame with 2,195 amino acids.

This paper examines patterns and drivers of energy choices for cooking and lighting in South Africa using the Statistics South African (StatSA, 2022) Census data at district municipality (districts) levels. Employing spatial and regression analysis, the findings show that electricity is the main source of energy for cooking across South Africa. However, there is a large swathe of the country covering districts, such as Vhembe and Mopani in Limpopo, eastern Mpumalanga, KwaZulu-Natal, and northern Eastern Cape provinces, where wood is the predominantly used energy type for cooking. There is almost uniform use of gas for cooking across the country. Electricity is the main energy source for lighting in South Africa. It is followed by candles, likely explained by loadshedding, and surprisingly solar energy a distant third. In terms of drivers, dwelling types play statistically significant role in what energy type to use for cooking and lighting, albeit differently. In terms of lighting, formal dwelling is positively related to the choice of electricity and informal dwelling is related to the choice of electricity (negatively) and candles (positively) for lighting. The level of higher education, household size, and the dependency ratio have varied statistically significant roles in the choice of either energy type for cooking or lighting by formal, informal, and traditional dwellers. Relevant policy prescriptions that are needed to engender the country towards sustainable energy use, diversification of energy types from electricity to other renewable energy sources, such as solar, and reduction in over-dependency on the biomass energy sources, such as paraffin and wood, especially in rural and poor districts, are proposed.

The forming of large rivers are the integral consequences of the deep earth process and the surface. In contrast to the hot topics for rivers related to orogenic domains, rift-related large rivers are largely ignored especially in deep time studies. The Cenozoic East Asia margin provides very good opportunity to observe this kind of rivers. It has been believed that basin-and-swell physiography dominated the East Asia margin and impeded the forming of large rives in the early Cenozoic. In this paper, we combined provenance analysis of East China Sea Basin, where is a crucial place to trace the river evolution in East Asia margin, and regional geologic constraints to reveal drainage reorganizations. Detrital zircon U-Pb ages from the Early Eocene sediments of the East China Sea Basin are firstly reported. Our results together with literature data demonstrate that regional provenance changes occurred at the middle Eocene from one singe age peak at ~110 Ma of proximal sources to multiple age spectrum derived from far inland. Source to sink analysis indicated that the North China Block and Korea Peninsular provided the most detritus. Sedimentation and tectonic features of rift basins in the potential source areas indicated that rivers flowed into Bohai Basin and Jianghan Basin cannot provide terrigenous clasts for the lower reaches in the Eocene. Contrastingly, the dominantly fluvial sediments across the Subei-South Yellow Sea Basin suggested external river system and a bypassing region since the middle Eocene, coinciding with provenance change in ECSB. All these demonstrated that a large river (East Asia River) established in east Asia margin in the middle Eocene and flowed southwestward approximately 1500km to the sea in southern ECSB. This river might last to the middle Miocene. The deep earth processes driven by Izanagi-Pacific ridge subduction resulted in the overfilled stage of Subei-South Yellow Sea Basin and the post-rift subsidence in west depression of ECSB, and thus facilitated the initiation of the EAR. Our finding shed new light on the evolving landscape in East Asia and showed how subduction of deep earth process controlled the initiation of rift-related large rivers.

Available water resources in the Middle East, as one of the most water-scarce regions of the world, have undergone extra pressure due to climatic change, population growth, and economic development during the past decades. The objective of this study is to detect the trends and quantify the changes in aridity with respect to precipitation and potential evapotranspiration in 20 countries of the Middle East and the adjacent area. A Pixel-wised trend analysis was conducted on precipitation, potential evapotranspiration, and aridity index for 71 years from 1948 to 2018. A nonparametric Mann-Kendall test was used over 14106 points in the study area to detect the trends at monthly and annual time scales. Results showed statistically significant (|Z| >1.96) upward trends in aridity (a downward trend in aridity index) up to 96 percent from December through September in most parts of the region. Aridity in October and November had a downward tendency in most parts of the study area. At the annual time scale, 62.5 percent of the statistically significant trends in aridity were found to be upward (up to 96 percent increase in aridity) due to the combined effects of the decrease in precipitation and the increase in potential evapotranspiration and 37.5 percent of the detected trends were downward (up to 61 percent decrease in aridity). The highest and the lowest trends in aridity were found in the north of Sudan (96 percent increase in aridity) and Eastern Arabia (61 percent decrease in aridity), respectively.

The Middle East spans the transition between temperate Mediterranean climate in the Levant to hyper-arid sub-tropical deserts in the southern part of the Arabian Peninsula, with the complex alpine topography in the northeast feeding the Euphrates and Tigris rivers which support life in the southeastern Fertile Crescent (FC). Climate projections predict severe drying in major parts much of the ME in response to global warming, making it important to understand the controls of hydro-climate perturbations in the region. Here we discuss 23 ME speleothem stable oxygen isotope (δ¹⁸Occ) records from 16 sites from the SISAL_v1 database, which provide a record of past hydro-climatic variability. Sub-millennial changes in ME speleothem δ¹⁸Occ values primarily indicate changes in past precipitation amounts superimposed on variations of the main synoptic pattern in the region, specifically Mediterranean cyclones. The coherency (or lack thereof) between regional records is reviewed from Pleistocene to present, covering the Last Glacial Maximum (LGM), prominent events during deglaciation, and transition into the Holocene. The available speleothem δ¹⁸Occ time-series are investigated by binning and normalizing at 25-year and 200-year time windows over the Holocene. Important Holocene climatic oscillations are discussed, such as the 8.2 ka, 4.2 ka and 0.7 ka (the Little Ice Age) Before Present events. Common trends in the standardized anomalies are tested against different climate archives. Finally, recommendations for future speleothem-based research in the region are given along with comments on the utility and completeness of the SISAL database.

Sustainable development goals (SDGs) are a global agenda consisting of 17 goals which are to be achieved in 2030 by all member states. SDGs are more holistic goals i.e. these goals are closely interrelated and they affect the progress of one another. Sub-Saharan Africa countries are, once more lagging behind in the implementations of SDGs despite the efforts by governments, non-government organisations and international agencies. Rwanda, South Africa and Zambia where the three Sub-Saharan Africa countries on which the study focused. The three countries in this study were chosen on the basis that they cater to the general overview of African countries performance on SDGs. To conduct this study, a desk research method was adopted and secondary data was utilised. An in-depth analysis was done on the on three subs Saharan African countries i.e. Rwanda, South Africa, Zambia. Those goals where serious attention is needed are goals 1-9, 16 and 17. Most Sub-Saharan African countries performed better on goals 11, 12 and 15. It was concluded that the achievement of Sustainable development goals remains a mere dream for Sub Saharan Africa unless serious interventions are made.

Introduction Livestock abortigenic agents, which are microorganisms that lead to premature foetal death and expulsion before completion of the gestation period, are common in Africa and Asia. Abortion events cause economic losses by lowering reproduction (and hence herd/flock sizes) and effects on milk production. Despite the importance of livestock production for food security and livelihoods of millions of the world’s poorest communities, very little is known about the scale, magnitude or causes of livestock abortion in Africa. The aim of this review was to determine the current status of the burden of livestock abortion and surveillance measures adopted for livestock abortigenic pathogens in Africa and Asia, and to explore feasible surveillance technologies. Methodology A systematic literature search was conducted using Preferred Reporting of Systematic Reviews and Meta-analyses (PRISMA) guidelines in four databases for studies published between 1 Jan 1990 and 31 July 2021 that reported epidemiological surveys of livestock abortigenic pathogens in cattle, goats and sheep in Africa and Asia including; Brucella spp., Neospora caninum, Toxoplasma gondii, Rift valley fever virus, Coxiella burnetii, Chlamydia, Leptospira and Bovine viral Diarrhoea Virus. A meta-analysis was used to estimate the species-specific prevalence of the abortigenic diseases and the region where they were detected. Results In the systematic literature search, 48 full papers were included which in total included 50 species-specific surveillance reports from Africa and 19 from Asia. Adjusted median seroprevalence calculations estimated Brucella at 6.85% (range 1.2-11.6) of 9071 sheep, 3.35% (range 0.90-5.40) of 17,007 goats, 8.95% (range 0.50-63.60) of 171,733 cattle, Neospora at 6.80% (range 6.80 -6.80) of 555 sheep, 10.80 (range 10.80-10.80) of 185 goats, 12.65% (range 3.40- 25.60) of 3775 cattle, Toxoplasma at 27.50% (range 1.40 – 75.90) of 2284 sheep, 32.0% (range 20.00- 64.80) of 1226 goats, 7.50% (range 7.50 - 7.50) of 174 cattle, Coxiella at 9.20 (range 9.20 – 9.20) of 184 sheep, 24.20% (range 24.20-24.20) of 91 goats, 13.80% (range 13.80-13.80) of 217 cattle, Rift valley fever virus at 7.70 (2.40-40.00) of 874 sheep, 20.95 (range 2.50-40.00) of 547 goats, 7.45% (range 3.60-11.30) of 309 cattle, Bovine viral diarrhea virus at 78.90 (range 78.90 – 78.90) of 398 cattle, Leptospira at 70.50 (range 70.50 – 70.50) of 373 cattle and Chlamydia at 6.60 (6.60-6.60) of 803 sheep. We found that most studies, 45 (89%) used serological surveys, 1 (2%) used molecular and 1 (2%) reported to have used Mobile-phone based surveillance approach. Three studies (6.25%) of the 48 included were embedded in the national surveillance programs of the respective countries they were conducted, majority 89% were stand-alone cross-sectional studies. Conclusion In conclusion, livestock abortigenic pathogens are still a burden in many African and Asian countries.

Adherence is vital for medicine to have an effect, yet adherence is considered to be low. However, research into adherence tends to focus on quantitative analysis of performance, something which fails to perceive how people are adherent in their many different environments. As a contribution to gaining a deeper understanding, interviews were held with 30 individuals in UK, Egypt, Kazakhstan and 6 countries in sub-Saharan Africa to understand their perceptions on adherence for a range of drugs, and these were compared with an existing well-regarded list. New reasons for non-adherence were discovered, and a new viewpoint on adherence derived which considers adherence to be a single act and therefore as an individual opportunity to be adherent, permitting greater focus on the enablers and inhibitors of adherence at a point in time.

This article describes the challenges, pharmacological strategies, and recommendations for managing multidrug-resistant breast cancer in Sub-Saharan Africa (SSA). By examining the current breast cancer treatment landscape, region-specific challenges, and promising pharmacological interventions, the objective is to bring to light the insufficient research on breast cancer and its multidrug resistance in this part of the world and guide healthcare professionals, policymakers, and researchers in developing evidence-based strategies for improved breast cancer care in SSA. Breast cancer is the leading cause of cancer morbidity in SSA, necessitating continuous advancements in its management. This overview explores the evolution of breast cancer treatment, including surgery, targeted therapy, immunotherapy, radiotherapy, and chemotherapy. Despite these advancements, multidrug resistance poses a significant challenge, impacting treatment efficacy and patient outcomes.The article provides insights into various breast cancer treatment modalities, emphasizing surgery, targeted therapy, immunotherapy, radiotherapy, and chemotherapy. Each approach is discussed in detail, highlighting its significance in managing breast cancer. The effectiveness of these treatments is contingent on timely diagnosis and intervention. Multidrug resistance is examined as a critical obstacle in breast cancer treatment, elucidating its impact on treatment failure and patient outcomes. Mechanisms such as the efflux system, enhanced DNA repair, apoptosis inhibition, alterations in drug targets, and the tumor microenvironment contribute to multidrug resistance, emphasizing the need for a multifaceted understanding.The unique challenges faced in SSA regarding multidrug-resistant breast cancer are delineated. These include the lack of comprehensive data, late presentation and diagnosis, poor genomic studies, limited access to specialized care, financial constraints, inadequate infrastructure, and psychosocial support issues. Addressing these challenges is crucial for devising effective strategies. In response to multidrug resistance, the article discusses contemporary treatment strategies such as P-glycoprotein inhibitors, combined chemotherapy, and immunotherapy. Notable advancements, including the use of Tariquidar and synergistic effects of combined chemotherapy, are highlighted, presenting promising avenues for overcoming resistance.The article proposes recommendations to enhance breast cancer management in SSA, encompassing strengthening primary healthcare services, creating specialized oncology facilities and long-term monitoring and data collection. Breast cancer management in SSA is multifaceted, marked by challenges and evolving solutions. Multidrug resistance remains a significant hurdle, demanding a holistic approach. Promising advancements in pharmacological interventions offer hope, while comprehensive recommendations serve as a roadmap for progress. By implementing these strategies, SSA can substantially improve multidrug-resistant breast cancer care and overall patient well-being.

Pharmacogenomics may improve patient care by guiding drug selection and dosing, however this requires prior knowledge of the pharmacogenomics of drugs commonly used in a specific setting. The aim of this study was to identify a preliminary set of pharmacogenetic variants important in Southern Africa. We describe co-morbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV, and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using literature, a list of pharmacogenes vital in disposition of the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred in 31.5% of the participants and statins were frequently prescribed cholesterol lowering drugs. HIV was reported in 20.3% of the study participants with lamivudine/stavudine/efavirenz being the most prescribed antiretroviral combination. Based on these data, pharmacogenes of immediate interest in Southern African populations include ABCB1, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, SLC22A1, SLCO1B1 and UGT1A1. Variants in these genes are a good starting point for pharmacogenomic translation programs in Southern Africa.

Is human capital heterogeneity a decisive factor for Chinese enterprises to invest in Africa? Based on the Outward Foreign Direct Investment (OFDI） data of Chinese enterprises in 37 African countries from 2007 to 2017, this paper using the FGLS model, is the empirical analysis of the mechanism and effect of the human capital heterogeneity of host countries on OFDI location selection. The human capital heterogeneity can be divided into four dimensions: scale, quality, cost and structure, which can be measured by health level, education level, wage level, child dependency ratio and old-age dependency ratio. The results show that: (1) the host country's human capital scale and child dependency ratio structure have a significant positive impact on decision-making for OFDI; (2) the cost of human capital and the structure of old-age dependency ratio are negatively correlated with the inflow of OFDI; (3) different from the existing conclusions, the quality of human capital will inhibit the inflow of OFDI in the sample period; (4) the extended test shows that the quality of human capital has a significant positive impact on OFDI decision-making. The results of robustness test are reliable. Finally, according to the conclusion of this paper, policy recommendations are put forward.

Background. Predisposition to HIV+ is influenced by a wide range of correlated economic, environmental, demographic, social, and behavioral factors. While evidence among a candidate handful have strong evidence, there is lack of a consensus among the vast array of variables measured in large surveys. Methods. We performed a comprehensive data-driven search for correlates of HIV positivity in >600,000 participants of the Demographic and Health Survey (DHS) across 29 sub-Saharan African countries from 2003 to 2017. We associated a total of 7,251 and of 6,288 unique variables with HIV+ in females and males respectively in each of the 50 surveys. We performed a meta-analysis within countries to attain 29 country-specific associations. Results. We identified 344 (5.4% out possible) and 373 (5.1%) associations with HIV+ in males and females, respectively, with robust statistical support. The identified associations are consistent in directionality across countries and sexes. The association sizes among individual correlates and their predictive capability was low to modest, but comparable to established factors. Among the identified associations, variables identifying being head of household among females was identified in 17 countries with a mean odds ratio (OR) of 2.5 (OR range: 1.1-3.5, R² = 0.01). Other common associations were identified with marital status, education, age, and ownership of land or livestock. Conclusions. Our continent-wide search for variables has identified under-recognized variables associated with HIV+ that are consistent across the continent and sex. Many of the association sizes are as high as established risk factors for HIV+, including male circumcision.

Background: Human papillomavirus is a common pathogen that infects the skin and mucosal epithelium, is transmitted sexually; causes condylomas or squamous cell carcinomas. Two (16 and 18) of the 150 HPV serotypes are oncogenic types. Studies have been done on the infection by oncogenic human papillomavirus 16/18 and associated factors are found to be very limited in Ethiopia. Objective: This study aimed to assess the prevalence of oncogenic human papillomavirus infection (HPV 16/18) and associated factors among women. Methods: An institutional-based cross-sectional study was conducted among 337 women screened for cervical cancer in two hospitals in East Gojjam Zone from February to April 2021 G.C. Four BSc-qualified nurses who worked in the chosen hospitals collected the data using pretested questionnaire and an HPV test (OncoE6TM Cervical Test) specific to HPV16/18 in cervical swabs. Descriptive analysis was performed to determine the prevalence and a multivariate logistic regression model was used to identify the associated factors of HPV16/18 infection. Finally, statistical significance was declared at P < 0.05.Results: The prevalence of HPV infection was 14.2% (95% CI: 10.7% -18.1%). The mean age of the respondents was 36.7±9.1 years. Women with the age group of 55-65 years (AOR = 7.91, 95% CI: 1.95-32.09), early initiation of sexual intercourse (AOR = 5.36, 95% CI: 1.58-18.13), history of sexually transmitted infection (STI) (AOR = 3.52, 95% CI: 1.27-9.72), human immunodeficiency virus (HIV) positive status (AOR = 6.8, 95% CI: 1.99-23.54), and number of lifetime sexual partners (AOR = 4.37, 95% CI: 1.15-17.3) were important independent factors associated with the presence of oncogenic HPV infection. Conclusion and Recommendation: We found a relatively low prevalence of high-risk HPV infection. Age, early initiation of sexual intercourse at less than 18 years, STI of women, being HIV seropositive, and a number of sexual partners were important factors for high-risk HPV infection. Women aged > 46 years, women with early initiation of sex, a history of STI, being HIV positive, and a history of multiple sexual partners should be encouraged to be screened and vaccinated for HPV infection. Wider-ranging studies are also needed in HPV-infected women in association with the cervical lesion.

Nowadays, the demand of agricultural production increase, Moreover, the rapid increase of the population in Egypt led to an increase in the demand for food, prompting the government to reclaim more desert lands. Such a study contributes to providing information that contributes to the promising optimization of land resources. This study carried out in an area south Egypt covering 386,171.04 hectares (ha). Remote sensed data were manipulated for defining the land cover/use features. Setting up DEM configures the network of natural drainage flows via the descending slopes. It was a guide for allocating micro dams as water harvesting sites as well as minimizing the runoff hazards and managing the priority of land use suitability versus flood hazards. Land cover/use units were defined as terrestrial irrigated areas of sequentially herbacous crops and permanent trees covering 1387.83 ha in levees; 1608.82 ha in point bar; 718.89 ha in bow bar and 23938.29 ha in alluvial plain. Terrestrial natural vegetation is dominated by xerophytes herbaceous in wadis (123533.56 ha). Terrestrial non-vegetated areas includes bare areas of rock land (98102.59 ha) and 67201.57 in bajada. Artificial non linear surfaces include buildings (5403.59 ha) and linear features include roads and railways (875.78 ha). Aquatic areas include artificial irrigation and drainage canals (1062.15 ha) and natural water body of River Nile course (2785.92 ha). Current land suitability for specific Land Utilization Types (LUTs) was assessed by matching soil attributes with the growth requirement of each LUT. Current land suitability can be improved by decreasing of salinity and framing practices. Accordingly, the land units can be potentially more profitable for increasing the ability of extra crops to be more productive. Old cultivated areas are the most profitable land cover/use units highly suitable (S1) for all LUTs comparing with other land cover categories.

PM_0.1 (particles diameter ≤ 0.1 µm), nanoparticles (NPs), and ultrafine particles (UFPs), were interchangeably used in the scientific communities. PM_0.1 originated from both natural and human sources. However, investigations of PM_0.1 and its effects on the environment, visibility, and human health risk to understand the levels of air pollution, sources, and impacts in South East Asia (SEA) countries continue to be lacking. The concentration of PM_0.1 in most SEA countries are much worse than those in western countries environment. A further motivation of this reviewed article is to provide a critical synthesis of the current knowledge and study of ambient PM_0.1 in SEA cities. The main influence of characteristics of PM_0.1 appears to be local sources including biomass burning and motor vehicles. Continuous monitoring of PM_0.1 in terms of both mass and number concentration should be further understood. A critical review is of great importance to facilitating air pollution control policies and predicting the behavior of PM_0.1 in SEA.

This paper examines the dynamic dependence structure of crude oil and East Asian stock markets at multiple frequencies using wavelet and copulas. We also investigate risk management implications and diversification benefits of oil-stock portfolios by calculating and comparing risk and tail risk hedging performance. Our results provide strong evidence of time-varying dependence and asymmetric tail dependence between crude oil and East Asian stock markets at different frequencies. The level and fluctuation of their dependencies increase as time scale increases. Furthermore, we find the time-varying hedging benefits differ at investment horizons and reduced over the long run.

Abattoir workers are liable to zoonotic infections from animals and animal products, pri-marily to diseases with asymptomatic and chronic clinical manifestations in animals such as brucellosis. No published reports exist on the seroprevalence of brucellosis in abattoir workers in South Africa. Therefore, this cross-sectional study was conducted to estimate the occurrence and risk factors for Brucella exposure in abattoir workers in Gauteng Province. A total of 103 abattoir workers and managers from six abattoirs, where brucellosis-positive slaughtered cattle and sheep were previously detected, were interviewed, and tested with serological assays using the Rose Bengal test (RBT), BrucellaCapt, and IgG-ELISA. A pre-tested questionnaire was administered to consenting respondents to obtain infor-mation on risk factors for brucellosis. Of the 103 respondents tested, the distribution of fe-male and male workers was 16 (15.5%) and 87 (84.5%), respectively. The seroprevalence for exposure to brucellosis was 21/103 (20.4%, 95%CI: 13.1-29.5) using a combination of RBT, BrucellaCapt, or IgG-ELISA. For test-specific results, seroprevalences by RBT, BrucellaCapt, and IgG-ELISA were 13/103 (12.6%, 95%CI: 6.9-20.6), 9/103 (8.74%, 95%CI: 4.1-15.9) and 18/103 (17.5%, 95%CI: 10.7-26.2), respectively. Low-throughput abattoirs were identified as associated risk as 29.3% of workers were seropositive compared to 12.7% of workers in high-throughput abattoirs, which highlights that direct contact at abattoirs poses higher risk to workers than indirect and direct contact outside abattoirs. This study confirmed the occurrence of Brucella spp. antibodies among abattoir workers in South Africa, possibly due to occupational exposure to Brucella spp. and highlight the occupational hazard to workers. Furthermore, findings underscore that abattoir facilities can serve as points for active and passive surveillance for indicators of diseases of public health importance. We recommend periodic implementation of brucellosis testing of abattoir workers country-wide to establish baseline data for informing appropriate preventive practices and reduce the potential burden of infection rate among these high-risk workers.

Arboviruses represents a real public health problem globally and in the Central African subregion in particular that represents a high risk zone for the emergence and re-emergence of arboviruses outbreaks. Furthermore, an updated review on the current arboviruses burden and associated mosquito vectors is lacking for this region. To contribute in filling this knowledge gap, the current study was designed with following objectives: (i) to systematically review data on the occurrence and distribution of arboviruses and mosquito fauna and (ii) to identify potential spillover mosquito species in Central African region in the last 30 years. Web search enabled the documentation of 2454 articles from different online databases. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) and The Quality of Reporting of Meta-analyses (QUORUM) steps for a systematic review enabled the selection of 164 articles that fulfilled our selection criteria. Of the six arboviruses (Dengue Virus (DENV), Chikungunya Virus (CHIKV), Yellow Fever Virus (YFV), Zika Virus (ZIKV), Rift Valley Fever Virus (RVFV), and West Nile Virus (WNV)) of public health concern studied, the most frequently reported were Chikungunya and Dengue. The entomological records showed >248 species of mosquitoes and regrouped under 15 genera with Anopheles (n= 100 species), Culex (n= 56 species) and Aedes (n=52 species) having high species diversity. Three genera were rarely represented with only one species and included: Orthopodomyia, Lutzia, and Verrallina, but individuals of the genera Toxorhinchites and Finlayas were not identified upto the species level. We found that two Aedes species (Ae. aegypti and Ae. albopictus) colonised the same microhabitat and were involved in major epidemics of the six medically important arboviruses and other less frequently identified mosquito-genera consisted of competent species and were associated with outbreaks of medical and zoonotic arboviruses. The present study reveals high species richness of competent mosquito-vectors that could lead to the spillover of medically important arboviruses in the region. Although epidemiological studies were found, they were not regularly documented and this also applies to vector competence and transmission studies. Future studies will consider unpublished information in dissertations, technical reports from different countries to enable it more consistent. A regional project entitled: Ecology of Arboviruses (EcoVir) is underway in three countries (Gabon, Benin and Cote d’Ivoire) to generate a more comprehensive epidemiological and entomological data on this topic.

South Africa is a water stressed country experiencing mass urbanisation especially towards coastal cities. The country is already enduring the impacts of global warming and climate change with risk of water scarcity in many areas. The risk was evident with Cape Town near encounter with ‘Day Zero’ i.e., the day when water supplies would have been switched off and residents required to queue for daily water rations. The drought exposed the inadequa-cies of the existing water supply system. Paradoxically, in the same drought period, vast amounts of unutilized stormwater that could have augmented water supply run unabated into the ocean through rivers around the city. The study determined that the problem was not necessarily water shortage but lack of adequate water storage. This study investigated the suitability of coastal reservoirs for stormwater harvesting on the over 3000 km South African coastline. The objective was to identify suitable locations for coastal reservoirs. The study un-dertook a systematic process of selecting several candidate locations and eliminating unsuita-ble sites based on international best practice i.e., coastal topography, climate, hydrology, fluvi-al environment, catchment size and river water quality. Nine candidate sites were identified and ranked based on suitability and associated benefits. The identified locations in order of ranking include Knysna River, Berg River, Buffalo River, Kowie River, Thukela River, Orange River, Port of Richards Bay, Port of Durban, and Lourens River. The Knysna site, with a mean annual precipitation of 600 - 800 mm/annum and mean annual runoff of 100 - 500 Mm3/annum, was determined to be the most optimal location.

Most schoolchildren carry schoolbags, of which a substantial proportion carry loads that exceed 15% of their body mass. Although the effects of loading have been investigated to varying degrees, the status of schoolbag loading and the acute affects thereof on gait and posture have not been thoroughly investigated within the South African context. A total of 60 participants in the 10-13-year age range volunteered for the present study. Significant differences were evident for relative load carriage (χ2(3) = 14.54, p &lt; .001), forefoot and heel forces (Mdiff = 17.05-34.86 N, p &lt; .001), force-ratios (Mdiff = 0.02, p = .029), and gait speed (Mdiff = -0.18 km/hr, p = .016).), but not for any postural angles (Mdiff = -3.37-6.08 deg, all p &gt; .052). Those who exceeded 15% BM were ~9 times more likely to report pain than those below 15% BM. The children in the current carried significantly heavier realtive loads (p &lt; .001) compared to similarly aged children from other countries. Loading leads to acute changes in posture and gait that are likely not meaningful. However, excessive loading (&gt;15% BM) leads to significantly higher perceptions and reporting of pain in 10-13 year-old children.

In tropical Africa, forests and savannas are the two most widespread biomes and potentially represent alternative stable states with divergent species composition. A classic, but untested, hypothesis posited by White (1983) suggests that the transition zones between forests and savannas contain a floristically impoverished assemblage with few representatives from each biome. Further, the evolutionary dimension of diversity has received limited attention, despite its importance for understanding the biogeographic history of biomes. Here, we quantify species richness and several measures of evolutionary diversity in 1° grid cells, using c. 300K occurrence records of trees and shrubs combined with biome affiliation data for 3,125 species. We find that assemblages in transition zones hold fewer woody species than assemblages in forest and savanna zones, as posited by White. However, transition zones hold more phylogenetic diversity than expected given their species richness, whether one considers forest and savanna assemblages separately or together. We also show that the Congo basin forest has low levels of phylogenetic diversity given the number of species and highlight south-eastern African savannas as a centre of savanna woody species richness and phylogenetic diversity. Regions with high phylogenetic diversity given the number of both forest and savanna species were centred around the Dahomey Gap and Cameroon, mainly in transition zones. Overall, our study shows that even if floristically impoverished, transition zones lead to unexpectedly high evolutionary diversity, suggesting they are important centres of evolutionary innovation and diversification.

Emerging information on the interactions between the COVID-19 pandemic and global food systems has highlighted how the pandemic is accentuating food crises across Africa. Less clear, however, are how the impacts differ between farming systems. Drawing on 50 key informant interviews with farmers, village leaders and extension officers, in South Africa and Tanzania, we identify the effects of COVID-19 and associated measures to curb the spread of the disease on farming production systems, the coping mechanisms adopted by farmers, and explore their longer-term plans for adaptation. We focus on a diverse range of production systems, from small-scale mixed farming systems in Tanzania, to large-scale corporate farms in South Africa. Our findings highlight how COVID-19 restrictions have interrupted the supply chains of agricultural inputs and commodities, increasing the storage time for produce, decreasing income and purchasing power, and reducing labour availability. Farmers’ responses were heterogeneous, with highly diverse small-scale farming systems and those less engaged with international markets least affected by the associated COVID-19 measures. Large-scale farmers were most able to access capital to buffer short-term impacts, whereas smaller-scale farms shared labour, diversified to subsistence produce and sold assets. However, compounded shocks, such as recent extreme climate events, limited the available coping options, particularly for smaller-scale and emerging farmers. The study highlights the need to understand the characteristics of farm systems to better equip and support farmers, particularly in contexts of uncertainty. We propose that policy actions should focus on (i) providing temporary relief and social support and protection to financially vulnerable stakeholders, (ii) job assurance for farmworkers, and engaging an alternative workforce in farming, (iii) investing in farming infrastructure, such as storage facilities, digital communication tools, and extension services, and iv) supporting diversified agroecological farming systems.

Objective In this study, we aim to synthesize some evidence on the impacts that COVID-19 is having on the epidemiology of Antimicrobial Resistance (AMR) in Africa since it was declared global pandemic by WHO in March 2020. Methodology A scoping review was undertaken by collecting and curating relevant resources from peer-reviewed articles and also from the gray literature. Mixed approaches of extracting data (qualitative and quantitative) were employed in synthesizing evidence, as suggested by Health Evidence Network (HEN). Findings A model constructed based on the synthesis of early evidences available on the effects of factors linked to COVID-19 in impacting the evolution of AMR in Africa predicted that, in cumulative terms, those factors favoring the evolution of AMR outpace those disfavoring it by no less than three folds. Conclusion COVID-19 is fueling the evolution of AMR almost unhindered in Africa. Due recognition of this crisis, concerted efforts for resource mobilization and global cooperation are needed to tackle it.

Energy demand has been overgrowing in developing countries. Moreover, the fluctuation of fuel prices is a primary concern faced by many countries that highly rely on conventional power generation to meet the load demand. Hence, the need to use alternative resources such as renewable energy is crucial to mitigate fossil fuel dependency alongside the reduction of Carbon Dioxide emission. Algeria’s being the largest county in Africa has rapid growth in energy demand since the past decade due to the significant increase of residential, commercial, and industry sectors. Currently, the hydrocarbon-rich nation highly dependent on fossil fuels for electricity generation, where renewable energy only has a small contribution to the country’s energy mix. However, the country has massive potential for renewable energy generations such as solar, wind, biomass, geothermal, and hydropower. Therefore, the government aims to diversify away from fossil fuel and promoting renewable energy generations through policies and renewable energy-related programs. The country’s Renewable Energy and Energy Efficiency Development Plan focuses on large scale solar, wind generation as well as geothermal and biomass technologies. This paper provides an update on the current energy position and renewable energy status in Algeria. Moreover, this paper discusses RE policies and programs that aim to increase the country’s renewable energy generation and its implementation status.

South Africa is afflicted with the worst epidemic of HIV in the world a legacy of the system of oscillating migrant labour in the region and the consequent social disruption that was the legacy of Apartheid. The initial response from the national government was slow and ineffective but once the magnitude of the epidemic became apparent the government began to respond. The investment in HIV- and TB-related activities in 2013 was R22 Bn or (US$2.5; 2013 exchange rate) of which the South Africa government contributed 80% and the Presidents Emergency Plan for AIDS Relief (PEPFAR) 17%. South Africa now has the more people on anti-retroviral therapy than any other country and treatment is being started much sooner after infection. Much of the best biomedical, virological, immunological, mathematical and social science around the treatment and prevention of HIV and AIDS and the associated epidemic of TB has been done by South African’s and their international collaborators. If the efforts to control the epidemic are maintained South Africa is on track to meet the UNAIDS 90-90-90target by 2020 and to End AIDS by 2030 in spite of the magnitude of the problem. While individual, patient level data are increasingly available, especially in the Western Cape, much greater efforts need to be made to ensure that the information collected in this way is used to give feedback and support to clinic staff, to ensure that health clinics are providing the best possible service, and to individual patients and people living with HIV to ensure that they are receiving the best possible care and support. South Africa needs to make better use of the rich and detailed data that are being collected from individual clinics and their patients to identify problems or difficulties at the clinic level and to ensure that individual patients are retained on treatment, are virally suppressed and receive the best possible care and support.

Human genetic studies have long been vastly Eurocentric, raising a key question about the generalizability of these study findings to other populations. Because humans originated in Africa, these populations retain more genetic diversity, and yet individuals of African descent have been tremendously underrepresented in genetic studies. The diversity in Africa affords ample opportunities to improve fine-mapping resolution for associated loci, discover novel genetic associations with phenotypes, build more generalizable genetic risk prediction models, and better understand the genetic architecture of complex traits and diseases subject to varying environmental pressures. Thus, it is both ethically and scientifically imperative that geneticists globally surmount challenges that have limited progress in African genetic studies to date while meaningfully including African investigators, as greater inclusivity and enhanced research capacity affords enormous opportunities to accelerate genomic discoveries that translate more effectively to all populations. We review the advantages and challenges of studying the genetic architecture of complex traits and diseases in Africa. For example, with greater genetic diversity comes greater ancestral heterogeneity; this higher level of understudied diversity can yield novel genetic findings, but some methods that assume homogeneous population structure and work well in European populations may work less well in the presence of greater diversity and heterogeneity in African populations. Consequently, we advocate for methodological development that will accelerate studies important for all populations, especially those currently underrepresented in genetics.

BACKGROUND G6PD deficiency is an inherited an X-linked recessive condition leading to insufficient levels of glucose-6-phosphate dehydrogenase, thus causing hemolytic anaemia under certain conditions. METHODS Our study is explorative for cases admitted to Jordan University Hospital. The studied parameters include demographics, clinical manifestations, biochemical markers including Hb level, WBC count, liver enzymes, and blood grouping. RESULTS Most of the patients were admitted to the emergency unit (53.13%). Individuals who were Rh-positive represented 57.81%, while patients of AB blood group accounted for 75%. The mean values were 4.81 years (age), 29.06 hours (time-to-hospital admission), 38.10 degree Celsius (temperature), 6.11 gm/dl (Hb), 13242.19 (WBC count), 343.20 U/L (S. ALP), and 50.98 IU/L (S. ALT). There was no significant difference between males and females or between favism-induced versus drug-induced hemolytic episodes. AB and Rh positive blood groups are of protective effect in relation to liver enzymes. Patients who were admitted to the hospital within 24 hours from having clinical manifestations had a better prognosis. CONCLUSION This study is the first inferential research on G6PD deficiency from the Middle East to explore cases from one of the largest healthcare centres in Jordan. The role of blood grouping should be investigated prospectively.

Epiphytic lichens are well-known indicators of air contamination. The chemical composition of lichens is affected by the concentration of pollutants in the environment. Usually, researchers assess long-term variations in trace elements or other pollutants in the study area or identify the spatial features of air contamination. The aim of this study is to create a database of trace element concentrations in the samples of the epiphytic lichen Hypogymnia physodes growing in the Kaliningrad region. The database can be used as a ‘reference point’ for monitoring studies. Another objective is to identify the spatial patterns of iron, manganese, nickel, cadmium, silver, lead, strontium, rubidium, and calcium in the Kaliningrad region. The samples of wild lichens were collected from pine and birch trees 1.2-1.8 m from the bases of the threes, using a regular grid, in August 2010. One-two-year-old thalli were used in the chemical analysis. The metals Ag, Cd, Cu, Pb, Ni, Fe, Mn, and Zn were determined by AAS (Mn, Fe by flame AAS and the others by ETA-AAS) and the elements Sr, Rb, and Ca by X-ray fluorescence. The concentration of metals in the western coastal area (the Sambian or Kaliningrad Peninsula) is higher than it is in the central and eastern parts of the region. Principal component factor analysis was carried out to detect and characterise different pollution sources and to identify the most polluted areas. The factors of metal emission were described. The authors examined the features of the spatial distribution of trace elements. Prevailing winds are form south-west. Therefore, the highest concentrations of trace elements were found on the Sambian peninsula and on the coasts of the Vistula and Curonian Lagoons. The high concentrations of trace elements in the samples of the lichen H.physodes, which were observed in the coastal part of the region, are associated with human impact and subsequent pollution. The chemical composition of lichens on the Sambian peninsula may have developed under the impact of both local pollution sources – vehicles, thermal energy facilities, and ports – and such factors as transboundary traffic and sea spray.

The arguments on the origin and evolution of the evergreen broad-leaved forest in eastern Asia, especially in the evolutionary process, exist generally, even contrary in some cases. The origin and evolution of the flora of eastern Asia, the formation time of Asian monsoon, and the implications from phylogenetic and molecular biogeographic studies in some important taxa, as well as in palaeobotanical evidences, are debatable. Most researches from different disciplines suggested that the monsoon in Miocene is a key to diversification of eastern Asian flora and its evergreen broad-leaved forest. The common view is that the evergreen broad-leaved forest of East Asia is closely related to the monsoon intensity and developments, which are caused by the uplift of Himalaya-Tibet, during or after the mid-Miocene. The analysis on the floristic elements show that the present subtropical evergreen broad-leaved forest in eastern Asia could have an early or ancient tropical origin and a tropical Asian affinity, but their species are dominated by the Chinese endemic or eastern Asian distribution, many of which are the tropical sister ones. The time of Himalayan uplift and intensity of monsoon climate is believed the key for the formation of the evergreen broad-leaved forest in eastern Asia. Combined existing palaeobotanical findings, the uplift of Himalayas and the formation of monsoon climate, as well as floristic elements of the subtropical evergreen broad-leaved forest, we believe that it was evolved from a Asian tropical rain forest after mid-Miocene in southeastern region of eastern Asia, while the ancient subtropical evergreen broad-leaved forests in southwestern region continuously evolved into the present subtropical ones.

In response to the fire protection design challenges faced by the integrated station-city engineering under the new model of station-city fusion, such as large building volume, diverse traffic types, functional integration, spatial complexity, and inapplicable standards, this paper selects Chongqing East Station as a typical engineering case. The fire safety engineering methods and performance-based fire protection design ideas were used. The paper summarized the fire protection difficulties, such as multifunctional combination construction, large fire protection distance, large fire protection zoning area, long evacuation distance, and design of evacuation (quasi) safety zones. Combining with the actual situation of the engineering, this paper analyzed the basic technical measures taken to address these design challenges. By adopting the method of fire safety engineering, the safety of the design scheme is verified, which can provide a solution approach for the current fire protection design challenges in the integrated station-city engineering.

Evidence regarding the effect of psychological factors and evacuation on cardiovascular disease occurrence after large-scale disasters is limited. This prospective study followed up a total of 37,810 Japanese men and women aged 30–89 years from the Fukushima Prefecture with no history of stroke or heart disease at baseline (2012), until 2017. This period included 3000 cardiovascular events recorded through questionnaires and death certificates. The participants’ psychological distress, trauma reaction, and evacuation status were defined, and divided into four groups based on combinations of psychological factors and evacuation status. We calculated the hazard ratios and 95% confidence intervals for only psychological, only evacuation, or both of them compared with neither using Cox proportional hazard models. Psychological factors along with evacuation resulted in approximately 5% to 25% higher magnitude of stroke and heart disease risk than psychological factors only among men. Compared to neither, the multivariable hazard ratios of those with both psychological distress and evacuation were 1.75 for stroke and 1.49 for heart disease, and those of both trauma reaction and evacuation were 2.01 and 1.57, respectively, among men. Evacuation combined with psychological factors increased the risk of stroke and heart disease risks especially in men after the Great East Japan Earthquake.

Pyrochlore group minerals are the main raw phases in granitic rocks of the Katugin complex-ore deposit that stores Nb, Ta, Y, REE, U, Th, Zr, and cryolite. They are of three main generations: primary magmatic (I), early postmagmatic (II), and supergene (III) pyrochlores. The primary magmatic phase (generation I) is fluornatropyrochlore with high concentrations of Na2O (to 10.5 wt.%), F (to 5.4 wt.%) and REE2O3 (to 17.1 wt.%) but low CaO (0.6-4.3 wt.%), UO2 (to 2.6 wt.%), ThO2 (to 1.8 wt.%), and PbO (to 1.4 wt.%). Pyrochlore of this type is very rare in nature and limited to a few occurrences, such as rare-metal deposits of Nechalacho in syenite and nepheline syenite (Canada) and Mariupol in nepheline syenite (Ukraine). It may have crystallized synchronously with or slightly later than melanocratic minerals (aegirine, biotite, and arfvedsonite) at the late magmatic stage when Fe from the melt became bound making impossible the formation of columbite. Second generation pyrochlore formed at the early postmagmatic stage of the Katugin deposit. It differs from that of first generation in lower Na2O concentrations (2.8 wt.%), relatively low F (4 wt.%), and les occupancy of the A and Y sites at similar contents of other components. Generation III pyrochlore is a product of supergene alteration processes. It is compositionally heterogeneous and contains K, Ba, Pb, Fe, and significant Si concentrations but low Na and F. Its compositions mostly fall within the filed of hydro- and kenopyrochlore.

The human coronaviruses (CoV) include HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1, some known for decades. The severe acute respiratory syndrome (SARS) CoV briefly emerged into the human population but was controlled. In 2012 another novel severely human pathogenic CoV – Middle Eastern Respiratory Syndrome (MERS)-CoV was identified in the Kingdom of Saudi Arabia, where 80% of over 2,000 human cases have been recorded across five years. Targeted research remains key to developing control strategies for MERS-CoV, a cause of mild illness in its camel reservoir. A new therapeutic toolbox being developed in response to MERS is also teaching us more about how CoVs cause disease. Travel-related cases continue to challenge the world’s surveillance and response capabilities and more data are needed to understand unexplained primary transmission. Signs of genetic change have been recorded but it remains unclear whether any impact on clinical disease. How camels came to carry the virus remains academic to the control of MERS. To date, human-to-human transmission has been inefficient, but virus surveillance, characterisation and reporting are key to responding to any future change. MERS-CoV is not currently a pandemic threat; it is spread mainly with the aid of human habit and error.

(1)Background: Fascioliasis is considered a neglected tropical disease affecting an estimated 17 million people in more than 70 countries worldwide. The highest prevalence of human fascioliasis is found in regions where livestock farming and consumption of raw or undercooked freshwater plants are common, such as parts of Africa, Asia, Europe, and Latin America. It is responsible for over 90,000 disability-adjusted years of life due to associated abdominal complications. We conducted a study to investigate the prevalence of human fascioliasis through a systematic review and meta-analysis of all available literature in Sun-Saharan Africa.(2). Methods: We screened a total of 126 publications using pubmed online search engine databases; Web of Science and CAB for articles published within a 20-year period between 2000 and 2022. We used a comprehensive search method using a combination of terms, parasite and disease names. The initial search resulted in a screening of articles by title, abstracts and full texts. The relevant information on the prevalence of human fascioliasis in Africa was extracted. Of the 126 publications, 33 articles were selected for meta-analysis. The essential information required was extracted from these documents and determined through statistical analysis in Microsoft Excel for calculating the prevalence of human fascioliasis in sub-Saharan Africa. The variance of each study was assessed using a bimodal distribution and heterogeneity assessment using a I2 index. Analysis was performed using random effects models.(3)Results: A total of 271 articles were searched through the database search and 33 articles were eligible studies that provided qualitative information on the prevalence of human fascioliasis in Africa. These make up 12.17% (n=33). The pooled prevalence estimates for human fascioliasis are 0.032% (IVhet PPE: 0.032% (95%CI 1.4-6.53). The highest prevalence rate was observed in Egypt with a prevalence of 100%. The prevalence of human fascioliasis is very high in some sub-Saharan countries, partly due to neglect of diagnostics, demonstrating the bias of available information for decision-making in human fascioliasis across Africa, given the spatial presence, scarcity and incompleteness are region.(4)Conclusions: The prevalence of Human fascioliasis is very high in some Sub-Saharan Countries partly due to neglect in diagnostics. This presents how highly focal with spatial occurrences, scarcity and patchy the available information for decision making is on Human fascioliasis across the Sub-Saharan African region.

Cameroon introduced the malaria vaccine in its routine immunization programme on 22 January 2024, in the 42 districts out of 200, among the most at risk of malaria. A cross-sectional analysis of data on vaccine key events in the introduction roadmap and vaccine uptake during the first 30 days was conducted. In addition to available gray literature related to the introduction of the malaria vaccine, data on malaria vaccine uptake by vaccination session, collected through a digital platform, were analyzed. A total of 1,893 reports were received from 22 January 2024 to 21 February 2024 from 766 health facilities (85% of overall completeness). Two regions out of 10 recorded less than 80% of completeness. As of 21 February 2024, 13,811 children have received the first dose of the malaria vaccine, including 7,124 girls (51.6%) and 6,687 boys (48.4%). Thirty six percent of children were vaccinated through outreach sessions versus 61.5% through sessions in fixed posts. The overall monthly immunization coverage with the first dose was 37%. Early results have shown positive attitudes towards and acceptance of malaria vaccines. Suboptimal completeness of data reporting and low coverage highlight persistent gaps and challenges in vaccine rollout.

Antimicrobial resistance (AMR) is a worldwide healthcare problem. Multidrug resistant organisms (MDRO) have the ability to spread quickly owing to their resistance mechanisms. Although colonized individuals are crucial MDRO dispensers, colonizing microbes have the potential to turn pathogenic under certain conditions, leading to symptomatic infections in carriers. Carbapenemase producing Enterobacterales (CPE) are among the most important MDRO involved in infections and colonizations, associating with multiple resistance mechanisms and virulence factors, causing infections with severe outcomes. All research papers identified in the most comprehensive online databases which contained information related to the topic of this article were analyzed, and relevant data was extracted and included. The first information on CPE could be traced back to the mid-2000s, but pertinent data for many African countries was established in the past 5-8 years. Information is presented chronologically for each country. Although no clear conclusions could be drawn for some countries, it was observed that CPE colonizations are present in most African countries and carbapenem-resistance levels are rising. The most common CPE involved are Klebsiella pneumoniae and Escherichia coli, and the most prevalent carbapenemases are NDM-type and OXA-48-type enzymes. Prophylactic measures, such as screening, are required to combat this phenomenon.

Globally, the need for sustainable urban development has never been more urgent than now. This is because estimates indicate that more than half of the global population will be living in urban areas by 2050, with South Africa estimated at 80%. This paper focuses on socio-economic nuances that impede sustainable urban development, as well as the strategies that can accelerate sustainable urban development in South Africa. Through a literature review methodology, the analysis identified the following issues as impediments to sustainable urban development in South Africa, informal settlements and businesses, lack of consultations with urban citizens, unresolved apartheid legacies, violence, crime and insecurity, and migration and immigration intricacies in South Africa. The paper also established the strategies to accelerate sustainable urban development as working with informality and against it, promoting inclusivity and access to resources, formulating, and accelerating policy reforms, investing in rural areas and towns, and finally investing in superior technology and innovation. These findings imply that there is a need to seek alternative development models and approaches, to address social challenges such as poverty, unemployment, and poor housing, aspects that impact negatively on urban development planning and sustainable development. This is because the major challenges to sustainable urban development are human-related challenges, that need social and economic solutions. There is also a need to reduce rural-urban migration by developing rural towns to ease pressure in major towns which are already spilling over.

Background Although COVID-19 outcomes vary between and within countries, there is little published data on how aspects of social determinants of health (SDoH) affect COVID-19 outcomes in the African context. Objective The current study set to examine COVID-19 case and death rates and their correlates among African countries using data from different sources. Methods An ecological cross-sectional study comprising 28 African countries with a recent Demographic and Health Survey, DHS (2010-2018). Response variables were COVID-19 case and death rates (as of August 15, 2020). Covariates comprised three healthcare systems measures; rates of hospital beds (2005-2017), ventilators (2020) and doctors (2010-2018) per 10,000 population, and 9 broad topics common to multiple SDoH frameworks aggregated to the country level; geography (urban residence), wealth index, education, employment, crowding, and access to information. Rates per 10,000 population were calculated for healthcare measures and mapped for visualization. A Negative Binomial regression was used to assess whether aspects of SDoH are correlated with COVID-19. Results Our analysis indicated that 1 in 4 (25.1%) households in study countries are without clean water and handwashing access. Country-level health system capacity (hospital beds, ventilators, and medical doctors) varied considerably between the countries. Negative Binomial regression showed that the odds of COVID-19 morbidity and death was higher in countries with a high proportion of households without access to quality water and doctors per 10,000 people. Having a high proportional of educated women (1.003: 95% CI, 1.001 – 1.005), hospital beds per population and less people per room (0.959: 95% CI, 0.920 – 1.000) was negatively correlated with COVID-19 deaths while being insured and owning a mobile phone was correlated with illness. Conclusion Both aspects of SDoH and healthcare system contribute either negatively or positively to COVID-19 outcomes. Addressing healthcare system capacity and economic and environmental SDoH will be critical for mitigating the spread of COVID-19 and re-emerging diseases on the African continent.

Breast cancer remains one of the most deadly non-communicable diseases in the world. The incidence of breast cancer in South Africa is increasing, with rural African women presenting with advanced stages of the disease. In this study, we aim to explore sociocultural factors influencing breast cancer screening practices among rural African women. A qualitative exploratory study was conducted using semi-structured interviews with 22 rural African women selected by purposive sampling. Thematic analysis was used to analyze the data. In this study, four sociocultural factors were identified as influencing breast cancer screening practices among rural African women. These factors included psychological factors, habits, beliefs, and healthcare perception. Women in rural African communities have deep-rooted traditional beliefs and practices regarding breast cancer. Consequently, this influences women's preventative health behaviours regarding breast cancer screening. To increase the number of women participating in breast cancer screenings, it is vital to develop culturally sensitive health education programs. Engaging community healers will also help to increase the number of women participating in breast cancer screening.

Groundwater modeling is a useful tool for assessing sustainability in water resources planning. However, groundwater models are difficult to construct in regions with limited data availability. We illustrated how remote sensing data can be used leverage limited in situ data to build and calibrate a regional groundwater model in the Goulbi Maradi alluvial aquifer in Southern Niger in Western Africa. We used data from the NASA Gravity Recovery and Climate Experiment (GRACE) satellite mission to estimate recharge rates, the primary source of water to the aquifer. Additionally, we incorporated groundwater storage changes obtained from GRACE data from 2009 to 2021 to establish an overall water budget from which we could back-calculate groundwater withdrawals from pumping in the region. This approach allowed us to calibrate the model and then convert it to a predictive tool to analyze the impact of various assumptions about future recharge and groundwater extraction patterns associated with the development of groundwater infrastruction in the region. The results indicate that the Goulbi Maradi alluvial aquifer is sustainable, even an increase of groundwater extraction up to 28%.

Viral hepatitis remains one of the largest public health concerns worldwide. Especially in Central Africa, information on hepatitis virus infections has been limited, although the prevalence in this region has been reported to be higher than the global average. To reveal the current status of hepatitis B and C viruses (HBV and HCV) infections and the genetic diversity of the viruses, we conducted longitudinal surveillance in Gabon. We detected 22 HBV and 9 HCV infections in 2,047 patients with febrile illness. Genetic analyses of HBV identified subgenotype A1 for the first time in Gabon and an insertion generating a frameshift to create an X-preC/C fusion protein. We also revealed that most of the detected HCVs belonged to the “Gabon-specific” HCV subtype 4e (HCV-4e), and the entire nucleotide sequence of the HCV-4e polyprotein was determined to establish the first reference sequence. HCV-4e strains possessed resistance-associated substitutions similar to those of other HCV-4 strains, indicating that the use of direct-acting antiviral therapy may be complex. These results provide a better understanding of the current situation of hepatitis B and C virus infections in Central Africa, and will help public health organizations develop effective countermeasures to eliminate chronic viral hepatitis in this region.

Many educational institutions are using technology-enhanced learning. However, studies have shown that increased access to technological tools/gadgets is a precursor to incidents of cyberbullying. Using Bronfenbrenner’s Ecological Theory, we explored educators’ knowledge and intervention strategies regarding cyberbullying in schools. The design used in this study was qualitative and descriptive in nature. Purposive sampling technique was used to recruit a sample of eight educators working at secondary school in Johannesburg, South Africa. Data were collected using one-on-one interviews. Thematic analysis method was used to analyse the data. The findings revealed educators had sufficient knowledge of cyberbullying and how it affects learners in schools. However, interventions the teachers had put in place to prevent and manage incidences of cyberbullying were found to be ineffective due to parental disengagement and learners not reporting cases of cyberbullying. Recommendations for enhancing management of cyberbullying cases are provided.

Inherited retinal dystrophies (IRDs) are a global problem that is largely unaddressed, especially in Africa. Black indigenous Africans are rarely represented in research that develop genetic tests and genetic therapies for IRDs yet their genomes are more diverse. The aim of this literature review is to synthesize information on the IRD genetic research conducted among indigenous black Africans to identify challenges and opportunities for progress. PubMed was searched to identify empirical publications reporting the genetic analysis of IRDs among indigenous Africans. A total of 10 articles were selected for the review. Based on the information in the articles, the main genetic testing methods in use include next-generation, whole exome, and Sanger sequencing. The main IRDs characterized by the genetic tests include retinitis pigmentosa, Leber Congenital Amaurosis, Stagardt disease, and cone dystrophy. Examples of implicated genes include MERTK, GUCY2D, ABCA4, and KCNV2 for the four IRDs respectively. Research activities on the genetics of IRDs are generally scanty in Africa. Even in South Africa and North Africa where some research activities were noted, only a few indigenous black Africans were in the study cohorts. There is an urgent need for genetic research on IRDs, especially in East, Central, and West Africa.

Smart primary healthcare building facility services capture a new level of process and operational data through advanced monitoring, enabling experts to use the building facilities to produce significant and efficient healthcare service delivery within the individual spheres of influence. This study assessed the impact of IoT services on achieving smart primary healthcare building facilities in the rural area of South Africa to enhance primary healthcare delivery. The study identified three (3) basic constructs of IoT services that comprised the application of IoT location recognition and tracking services, the application of the IoT high-speed communication network-based services, and the application of IoT-based services. The study is quantitative, and a questionnaire was used to collect data from the project managers and healthcare practitioners working with the primary healthcare agency in South Africa. The study found a variable degree of impact between the three (3) IoT constructs and the achievement of primary healthcare building facility services in South Africa. The study recommends adopting IoT essential services for achieving smart primary healthcare building facility services in the rural areas of South Africa and other developing countries facing similar primary healthcare delivery challenges.

Psychological distress (PD) may be common among adolescents. The study aimed to estimate population-based rates of PD among adolescents in South Africa. National cross-sectional data were analysed from 2,240 adolescents (17 years median age) that participated in a community-based population survey, the “2012 South African National Health and Nutrition Examination Survey (SANHANES-1).” Results indicated that 16.0% of the adolescents had PD, 13.1% among boys and 18.5% among girls. In adjusted logistic regression analysis, increasing age, girls, belonging to the Black African population group, having experienced two or more traumatic life events, poor self-rated health status, having activity limitations, perceived body overweight, fast food and snack consumption were associated with PD. Almost one in six adolescents in South Africa reported PD and several associated factors were identified.

Coronavirus disease 2019 (COVID-19) since its declaration as a pandemic by world health organization (WHO) has spread across the various continent with little known about the most effective public health response for containing and mitigating the transmission of the epidemic. It is important to state that some authors have published on the lessons learned from transmission and management of COVID-19 infection but only a few considered it from the Africa perspective. Despite the late arrival of the pandemic in Africa and the notion that the virus may not thrive because of the high temperature in the continent; today the narrative has changed with the number of infected patients increasing daily. Herein, the authors have shared their perspectives and opinions on the dynamics and response to COVID-19 from Africa context to create more awareness and approach in mitigating the spread of the virus should the continent becomes the epicenter of COVID-19.

Over the past few decades, there have been major advances in crop productivity across the world, which has been made possible through a combination of productivity enhancing technological innovations. Beyond this achievement however, most parts of Africa are still battling with low crop productivity resulting in food shortages and food insecurity. The yields of many staple crops are still far below their agronomic potentials with output increases being attributed largely to area expansion. This paper examines the implications of the current trends of crop/plant productivity for food security and rural livelihood development in Africa using Ghana as a case study. The paper argues that crop production in Africa is becoming a less viable and unattractive livelihood activity with farmers diversifying out of agriculture into non-agricultural activities such as illegal small-scale mining, which have negative consequences on the ability of African countries to attain the Sustainable Development Goals (SDGs).

Chan and colleagues in their paper titled “Human origins in a southern African palaeo-wetland and first migrations” (https://www.nature.com/articles/s41586-019-1714-1) report 198 novel whole mitochondrial DNA (mtDNA) sequences and infer that ‘anatomically modern humans’ originated in the Makgadikgadi–Okavango palaeo-wetland of southern Africa around 200 thousand years ago. This claim relies on weakly informative data. In addition to flawed logic and questionable assumptions, the authors surprisingly disregard recent evidence and debate on human origins in Africa. As a result, the emphatic and high profile conclusions of the paper are unjustified.

Nowadays one of the issues interesting for researchers of political, social, and economic sciences is to investigate immigration from different angles. Accordingly, they use a diverse range of instruments, different types of graphs, descriptive indices and complex mathematical models. Immigration has always been one of the paths helping humans in their own efforts for getting compatible with the environment and coping with difficulties. Nevertheless, if this issue has been considered as an instrument regulating resources and species automatically, in the present era, its negative aspects have been evident and socioeconomic consequences of immigration in the framework of development economy and security has attracted scholars’ attentions. One of the countries attracting for immigrants particularly in the continent of Africa is South Africa. Statistics indicates that this country is the most attractive one for refugees. Somalis are one of the most important and largest groups seeking refuge in South Africa because they are usually merchants who earn money in the poor places. However, business in the poor places endangers their lives and properties because of high rate of crimes and xenophobia. As a result, the target countries face a lot of socioeconomic and security problems. The present study tries to investigate the issue of Somali immigration using network models.

Despite numerous interventions to promote gender equality, sub-Saharan Africa has one of the highest prevalence rates of non-partner sexual assault in the world, thus constituting a major social and public health issue in the region. As social workers frequently provide services to this population, an exploratory cross-sectional study was conducted to explore rape myth acceptance among undergraduate social work students studying in Namibia. Findings revealed the positive influence of social work education in reducing rape myth acceptance as well as highlighted the influence of age, gender, country of origin, self-identification as a feminist, and religiosity on rape myth acceptance among this population.

In sub-Saharan Africa (SSA), cervical cancer is a critical public health issue; it is the second leading cause of cancer among women and the leading cause of female cancer deaths. Incidence and mortality rates are substantially higher than in high-income countries with population-based screening programs, yet implementing screening programs in SSA has so far proven to be challenging due to financial, logistical and sociocultural factors. Human Papillomavirus (HPV) vaccination is an effective approach for primary prevention of cervical cancer and presents an opportunity to reduce the burden from cervical cancer in SSA. With a number of SSA countries now eligible for GAVI support for vaccine introduction, it is timely to consider the factors that impede and facilitate implementation of vaccine programs in SSA. This article reviews the epidemiological and clinical features of cervical cancer in SSA and describes the current status of HPV vaccine implementation in SSA countries. The review considers the challenges that will need to be addressed, and effective approaches to the design and implementation of HPV vaccination programs, using Rwanda as a case study. The review aims to provide suggestions and guidance to those involved in the development and implementation of HPV vaccination programs in SSA.

A checklist of parasitic cymothoids from Malaysian waters is presented based on available literature and material collected from 2010 to 2020. Most of the collected specimens were recorded from waters of Terengganu, east coast of Peninsular Malaysia (facing South China Sea), whereas literature records were represented from Sarawak, along the Miri coast of northwest Borneo. The checklist comprises 18 species under 10 genera, seven of which are new records from Malaysia, which includes Anilocra nemipteri Bruce, 1987; Ceratothoa barracuda Martin, Bruce and Nowak, 2015; Ceratothoa carinata (Bianconi, 1869); Cymothoa epimerica Avdeev, 1979; Elthusa sigani Bruce, 1990; Joryma engraulidis (Barnard, 1936) and Renocila richardsonae Williams and Bunkley-Williams, 1992. Eight new host records are based on collected specimens: Anilocra nemipteri was dorsally attached on Nemipterus nemurus (Bleeker 1857), Nemipterus nematophorus (Bleeker 1854), Nemipterus tambuloides (Bleeker 1853), and Nemipterus thosaporni Russell 1991 (family Nemipteridae); Ceratothoa carinata was found in the buccal cavity of Decapterus macrosoma Bleeker 1851 (family Carangidae); Cymothoa eremita (Brunnich, 1783) was attached in the buccal cavity of Nemipterus tambuloides and Nemipterus furcosus (Valenciennes 1830); Elthusa sigani was found attached on Pterois russelli Bennett 1831 (family Scorpaenidae); and Renocila richardsonae was attached on the caudal fin of Upeneus japonicus (Houttuyn 1782) (family Mullidae). All cymothoid species listed here are known to have a Central Indo Pacific distribution, with some ranging as far as the western Indian Ocean. The cymothoid-host association is here listed from 28 fish families, with the most common reported from Carangidae (pompanos, jack mackerels, runners, scads), Engraulidae (anchovies) and Leiognathidae (ponyfishes, slipmouths). This paper is the first comprehensive treatment to update both verified literature data and deposited specimens, with a key for the family Cymothoidae in Malaysian waters.

Seafood, especially from the ocean, is now seen as a greener and more sustainable source of protein causing an increase in its demand. This has also led to people making choices towards seafood as a replacement of carbon intensive protein sources. As a result, the demand for seafood is growing, and the Aquaculture industry is required to increase their produce while keeping the produce safe and sustainable. There are many challenges faced by the aquaculture industry in meeting these increased demands. One such challenge is the presence of harmful algal blooms (HAB) in the ocean which can have a major impact on aquatic life. In this paper we look at the impact of this challenge on aquaculture and the mitigating strategies. We will focus on Abagold Limited, a land-based marine aquaculture business that specializes in large scale production of abalone (Haliotis midae) based in Hermanus, South Africa. HABs are considered a threat to commercial scale abalone farming along the South-African coastline and requires continuous monitoring. The most recent HAB was in February-April 2019, the area experienced a severe red-tide event with blooms of predominantly Lingulodinium polyedrum. We present some of the mitigation strategies employing digital technologies for future proofing the industry.

Africa is a home to growing number of biosafety organisations that work to enhance public health in their nations by bringing attention to the significance of biosafety and biosecurity. Since many African countries are low-resource countries, they frequently confront a number of obstacles that seriously limit their ability to create or grow a sustainable capacity for managing biosafety and biosecurity. The goals of biosecurity and biosafety protocols are to reduce both intentional and unintentional biological risks that could have disastrous effects on a nation's health system, agriculture, security, political and economic stability. Regrettably, on a national, regional, and international level, biosecurity and biosafety are frequently given insufficient priority.Eventhough, Africa are home to a growing number of biosafety organisations that work to enhance public health in their nations by bringing attention to the significance of biosafety and biosecurity, Standard Biosafety and Biosecurity Measures to contain hazardous infections are missing across the African continent. In this paper the current state, challenges, and future prospects of biosafety and biosecurity status of African nations discussed.

Natural radioactivity of 238U, 232Th and 40K for liquid and solid samples collected from Sidi Salem dam (Tunisia) and Aïn Dalia dam (Algeria) were measured using TERRA detector of rays (gam-ma, beta, and alpha), Atomic adsorption and Gamma-ray spectrometry were used to analyze the levels of radionuclides and toxic heavy metals, respectively. Toxic heavy metals (Fe, Bb, Zn, Ni, Cu, Cr and Cd) and associated health risks in surface water and sediment of dams have been in-vestigated in this present study. The radioactivity mean rates in the water samples were 1.72±0.01, 0.068±0.01 and 94.6±1.04 Bql-1 for 238U, 232Th and 40K respectively (Tunisia dam) and were 1.9± 0.24, 0.09±0.01 and 131.43±1.03 Bql-1 for 238U, 232Th and 40K respectively (Algeria dam). The 238U, 232Th and 40K radioactivity mean concentration measured in the sediment samples were 2.67±0.01, 0.18±0.012 and 197.87±2.01 Bqkg-1 respectively (Tunisian dam) and were 4.34±0.05, 0.27±0.05 and 287.61±3.34 Bqkg-1 respectively (Algeria dam). The activity concentration of 40K was higher than that of 238U and 232Th for the water and sediment samples. The mean activity concen-trations follow the order 40K > 238U > 232Th. The cumulative impact can be a serious immediate radiological health burden on the ecosystem, environment and people's health in this study area and can be transposable to any other similar region. The good knowledge of monitoring quality and quantity for the transboundary water resources and the international collaborations are es-sential to safeguard human health (women’s breasts cancer, thyroid cancer, neurological im-pact…), and avoid the conflicts, especially during these climatic upheavals of drought.

On February 28, 2023, the Facebook page of the United Nations Children's Fund (UNICEF) South Africa, announced the beginning of the HPV vaccination campaign for 2023. The aim of this study was to examine the attitudes of Facebook users, who commented on the UNICEF South Africa post, towards HPV vaccination to inform the development and implementation of interventions that can increase HPV vaccine acceptance and uptake. Several comments were questions regarding the eligible criteria for vaccination, side effects, consent form, and vaccination strategies. Many Facebook users were hesitant towards HPV vaccination due to various reasons including concerns around side effects, religious beliefs, vaccine stock outs, and their distrust in the institutions or systems involved in vaccination programmes. Few users accepted HPV vaccination because they believed that it was very important thing to do, beneficial for the children’s health, and they have vaccinated they children before. Our findings of the current study contribute to the promotion of acceptance and uptake of HPV vaccination by developing and implementing interventions tailored to address identified barriers that are associated with hesitant to HPV vaccination.

(1) Background: Respiratory infections are a major public health problem worldwide, with potentially serious consequences. Indeed, these infections remain one of the main causes of morbidity and mortality in children under 5 years old in developing countries. Etiological information on respiratory infections is crucial for prevention and case management strategies. This systematic review aims to describe the etiology of respiratory infections reported in studies carried out in sub-Saharan African countries; (2) Methods: Using PubMed, HINARI and Google scholar search engines, a systematic search was carried out to identify published articles on the etiology of viral and/or bacterial respiratory infections in sub-Saharan Africa in patients of all ages. We have only considered data from sub-Saharan Africa. Papers published from 2010 to 2021, in English or French have been included in this review; (3) Results: After reviewing 115 articles reporting studies carried out in the African continent, only 32 articles were selected of which, studies were conducted in 15 sub-Saharan African countries, including 6/32 (18.75%) in Cameroon. Twenty (62.5%) were cross-sectional studies, and twenty-four (75%) were hospital-based investigations. In these studies, RT-PCR and culture methods were respectively used for viruses and bacteria investigations. Respiratory syncytial virus was the most frequently identified, with prevalence ranging from 0.6% to 59%, followed by rhinovirus (9.3% -73%), influenza virus (flu) A/B (0.9%-69.1%), and human adenovirus (0.9% - 30.8%). Streptococcus pneumoniae (14.2% - 96%), followed by Haemophilus influenzae type b (2.5% - 54%), and Klebsiella pneumoniae (1.4% - 49.9%) were the most frequently detected bacteria; (4) Conclusions: This review has reported that many pathogens, mainly viruses, are associated with acute respiratory infections in sub-Saharan Africa in both children and adults. Unfortunately, the limited geographical distribution of data across sub-Saharan Africa does not allow most of countries to develop an effective strategy for the prevention and treatment of respiratory infections.

For women giving birth, every moment of delay in receiving skilled care significantly increases the risks of stillbirth, neonatal and maternal death. More than half of all births in developing countries including South Africa, take place outside a health facility and without skilled birth attendants. This has therefore, made it difficult to achieve the Sustainable Development Goals of global reduction in maternal mortality, which is a key health challenge globally, especially in developing countries and sub-Saharan Africa in particular. The aim of this study was to explore and describe the views of pregnant women regarding facility-based delivery. Focus group discussions were used to gather information from the pregnant women. Information was collected from six groups of pregnant women who had delivered babies at the antenatal care facilities in the past years. Results showed several factors associated with the failure to use institutional delivery service, such as long distance from the health care facility, lack of transport, lack of transport fare, shortages of skilled staff, failure to disclose pregnancy, cultural and religious beliefs, and staff attitudes.

Cryptococcosis is a leading cause of death among people with HIV in sub-Saharan Africa. Limited diagnostic and therapeutic options significantly impair treatment options in Africa. We investigated the burden of cryptococcosis and related mortality among people with HIV and suspected sepsis in Ethiopia. We conducted a prospective cohort at 1) Adama Hospital Medical College and 2) Asella Referral and Teaching Hospital from September 2019 to November 2020. We enrolled adult HIV-infected patients presenting with suspected sepsis and assessed 28-day survival. We performed blood cultures and cryptococcal antigen (CrAg) testing. In total, 82 participants were enrolled with a median age of 35 years and 61% being female. Overall, 11(13%) had positive CrAg tests, of which 5 had Cryptococcus detected in blood cultures. Despite high-dose fluconazole (1200mg/d) monotherapy in patients with positive CrAg tests, the 28-day mortality was 64%(7/11), being significantly higher than in CrAg-negative patients (9%(6/71); p&lt;0.001). Cryptococcosis is the leading cause of mortality among HIV-infected sepsis patients. CrAg screening in HIV-infected patients attending emergency department can minimize the cryptococcosis missing case irrespective of CD4 count and viral load. These findings warrant the need of a bundle approach for diagnosis of HIV-infected persons presenting with sepsis in low- and middle-income countries.

Though there has been a decline in the number of new cases of viral hepatitis-induced acute liver failure in Europe and the United States of America, viral hepatitis still remains the leading cause of acute liver failure in Asia-Pacific and South America. However, the epidemiology of viral-hepatitis-induced acute liver failure in sub-Saharan Africa-the world epicenter of viral hepatitis-is unclear. The aim of this review was to collate data on the incidence, prevalence, specific etiologic agents, features/diagnosis, treatment and prognosis of viral-induced acute liver failure in sub-Saharan Africa. One hundred and forty-seven cases of viral-induced acute liver failure were recorded in 11 studies conducted in six countries between 1981-2020. Etiological agents were: Hepatitis viruses A, B, C, and E, as well as Adenovirus, Enterovirus, Parvovirus, Herpes Simplex Virus (HSV) and EBV. HAV was the most frequent in paediatric subjects: (11/16) 69% and (19/30) 63%. HBV was the only etiological agent in the study that only included adults. HEV (genotype 2 in one study) contracted amidst hepatitis E outbreaks was the most commonly reported cause of ALF in pregnant women. Treatment was mainly supportive, and liver transplantation reported only in South Africa. Where reported, case fatality rates were high. In conclusion, viral-hepatitis induced acute liver failure is largely understudied in sub-Saharan Africa. The few available data are consistent with literature from the other parts of the world regarding aetiologic agents. Liver transplantation is not available in most sub-Saharan African countries, and short-term case fatality rates of individuals with acute liver failure could outstrip current rates from the other world regions.

Digital transformation of agriculture can support economic growth and food and nutri-tion security in Africa. This study provides an overview of the status of digital agriculture in five west African countries, analyzing their efforts in developing the enabling environment and inno-vations while formulating recommendations based on the identified gaps for the effective trans-formation of the sector. Information was retrieved through a literature search from various sources, including web pages and databases of national agricultural and digital transformation institutions and start-ups of the five target countries (Benin, Burkina Faso, Côte d'Ivoire, Ghana, Nigeria) and regional/international institutions. There have been increasing agri-digital initia-tives in the five countries, which were grouped into seven categories based on their objectives. Steady progress was also observed in mobile internet adoption, despite the differences in deploy-ing crucial infrastructure to promote digital agriculture. The mobile connectivity index (MCI) in all five countries is below 60. Nonetheless, Ghana and Cote d'Ivoire demonstrated more efforts in internet and electricity access, especially in rural areas. Benin and Nigeria have developed sep-arate documents depicting the roadmap for Digital Agriculture, while the other countries are working to create one or have it embedded in their national development plans. Similarities and specificities exist among countries for laws and processes protecting Agri-digital innovators. To be competitive and self-reliant in the global e-economy, these countries must reposition them-selves to accelerate changes in digital agriculture through effective governance and synergy of actions in different sectors and across nations.

The tumor microenvironment (TME) plays a critical role in cancer progression and treatment outcomes. Despite advances in cancer research, many therapeutic strategies have failed to provide the desired clinical outcomes. In this integrated review, aimed to explore the role of TME in cancer biology and develop novel therapeutic strategies that target not only cancer cells but also the surrounding microenvironment. Study conducted a comprehensive literature search using PubMed, Embase, and Web of Science databases for articles published between 2016 and 2022. Inclusion of articles that discussed the impact of TME on cancer development and progression, as well as articles that proposed novel therapeutic strategies targeting the TME. The analysis of the literature revealed that the TME plays a crucial role in cancer development and progression by promoting cancer cell survival, angiogenesis, invasion, and metastasis, and by interfering with the efficacy of cancer therapies. The TME is composed of a complex network of non-cancerous cells, extracellular matrix components, and signaling molecules that interact with cancer cells. Several novel therapeutic strategies have been proposed based on the modulation of TME components. One of the most promising approaches is the use of immunotherapy, which aims to enhance the immune system's ability to recognize and attack cancer cells. Immunotherapy drugs such as checkpoint inhibitors, chimeric antigen receptor (CAR) T cells, and immune-stimulatory monoclonal antibodies have been approved for the treatment of different cancer types. These approaches have shown promising results in preclinical studies and clinical trials. The TME plays a critical role in cancer development and progression, and targeting its components represents a promising avenue for cancer therapy. Novel therapeutic strategies such as immunotherapy, extracellular matrix-targeting drugs, and nanoparticle-based therapies have shown promising results in preclinical studies and clinical trials. However, further research is needed to identify the most effective strategies and to overcome the challenges associated with TME targeting.

While vaccines are a well-established method of controlling the spread of infectious diseases, vaccine hesitancy jeopardizes curbing the spread of COVID-19. Through the Vaccine Information Network (VIN), this study explored barriers and motivators to COVID-19 vaccine uptake. We conducted 18 focus group discussions with male and female community members, stratified by country, age group, and—for Zimbabwe only—by HIV status. Participants’ median age across both countries was 40 years (interquartile range of 22–40) and most (65.9%) were female. We conceptualized the key themes within the World Health Organization’s Strategic Advisory Group of Experts on Immunization (SAGE) 3Cs (convenience, confidence, complacency) vaccine hesitancy model. Barriers to vaccine uptake—lack of convenience, low confidence, and high complacency—included inaccessibility of vaccines and vaccination sites, vaccine safety and development concerns, and disbelief in COVID-19’s existence. Motivators to vaccine uptake—convenience, confidence and low complacency—included accessibility of vaccination sites, user-friendly registration processes, trust in governments and vaccines, fear of dying from COVID-19 and knowing someone who had died or become infected with COVID-19. Overall, vaccine hesitancy in South Africa and Zimbabwe was influenced by inconvenience, a lack of confidence, and high complacency around COVID-19 vaccines.

Drowning is a serious public health concern. Low middle income countries are mostly affected, as they carry 90% of the global drowning burden. The purpose of this epidemiological study is to provide a comprehensive overview of fatal drownings in South Africa between 2016 and 2021. The data used for the study was obtained from the South African Police Service. Descriptive statistics were used to summarise data. Statistical analysis included a t-test and chi-square test. The results indicate that the average fatal drownings per annum is 1477 in South Africa, with a drowning rate of 2.54 per 100 000 population from 2016 - 2021. The KwaZulu-Natal province had the highest incidence of drowning. The 0 – 4-year category has a high prevalence of drowning amongst all the age categories. More males drowned in South Africa compared to females. The study highlights key areas of concern these include age, sex, race, province, type of water body and time of day. This information is crucial to inform drowning prevention initiatives in South Africa.

Targeting genes involved in sexual determinism for vector or pest control purpose, requires a better understanding of their polymorphism in natural populations in order to ensure a rapid spread of the construct. By using genomic data from An. gambiae s.l., we analyzed the genetic variation and the conservation score of the fru gene in 18 natural populations across Africa. A total of 34339 SNPs were identified including 3.11% non-synonymous segregating sites. Overall, the nucleotide diversity was low and the Tajima's D neutrality test was negative indicating an excess of low frequency SNPs in the fru gene. The allelic frequencies of the non-synonymous SNPs were low (freq < 0.26) except two SNPs identified at high frequencies (freq > 0.8) in the Zinc-finger A and B protein domains. The conservation score was variable throughout the fru gene with maximum values in the exonic compared to the intronic regions. These results showed a low genetic variation in overall the exonic regions especially the male sex-specific exon and the BTB-exon 1 of the fru gene. These findings are crucial for the development of a gene drive construct targeting the fru gene that can rapidly spread without encountering resistance in wild populations.

Countries in West Africa are adversely affected by climate change (erratic rainfall and rising temperature) resulting in floods, desertification, drought and sea level rise. These events are anticipated to have negative impacts on agricultural development on the continent, ultimately, contributing to food insecurity and environmental degradation. This implies that the production capacity of agrarian communities is unable to meet the food demand of the growing urban population. Can sustainable and innovative urban farming technology such as aquaponics achieve food security as well as sustainable development in countries vulnerable to climate change? This study uses inferential statistic to examine the plant growth performance in micro-scale aquaponics and specific growth rate per day (SGR) for the fish growth performance vis-à-vis conventional urban farming production. A quantitative analysis use to examine the barriers to adoption based on survey of (five) urban aquaculture practitioners in Lagos, Nigeria. Literature review was use to assess the economic feasibility of a small-scale aquaponics system in developing countries based on Net-Discounted Benefit-Cost Rate (DBCR). The results suggest that aquaponics can improve food security through fish and vegetable production and it is likely that urban farming practitioners will adopt the technology if support mechanism are in place. Aquaponics systems present a novel opportunity to promote environmental conservation as well as sustainable food production and consumption in urban areas in Western Africa if adequate financial credit and knowledge transfer is provided.

To bring to the fore the aim of this research, effects of fluctuating temperature, was measured against food and nutrition security in the region using food production index, and undernourished population growth rate as proxies; controlled over share of arable land, irrigation, population and labour share for agriculture. Dynamic panel of generalized method of moments (GMM) was adopted, the period 2000 to 2016 were considered and 29 countries in sub-Sahara Africa were selected within the empirical framework of global water balance as mentioned by Rai and Singh (2012). Findings from the study reveals that the short run effect of temperature increase in degrees pose at least -3.1% negative and significant impact effects on the food production while the long run elasticity hits -7.5% and the controlled effect on arable land revealed a positive impact on the food production to the tune of 3.9%. Contrarily, arable land expansion reduces the under nourished population by -8.55%. Population increase on the other hand increases undernourished population in the region to the tune of 11.95%. The study therefore recommended expansion in the arable land and encourages population control policy in order to negate the undesired effects of temperature on food and nutritional security.

There is growing adoption of corporate sustainability practice in both for-profit and not-for-profit organizations. This proliferation is largely due to the increasing concerns for social, environmental and economic factors in which we assume shared responsibility. Despite the growing attention of researchers and practitioners, several corporations failed to meet their sustainability responsibilities. Several reasons could be associated to this phenomenon such as lack of regulatory mechanism, accountability, etc. This review, however, seeks to examine how nongovernmental organizations (henceforth, NGOs) influence corporate sustainability adoption (i.e. sustainability reporting). In the review of prior research, we leveraged the institutional-legitimacy and corporate governance theories. The findings suggest that NGOs have greater potential in sustainability discourse through two salient actions, namely (1) collaborative partnership, and (2) confrontational tactics. While the former promotes stakeholder involvement in corporate decision making through dialogue, joint-projects on CSR, sustainability reporting, the latter, however, is the last resort – involving “naming and shaming” corporations for poor social and environmental performance through public and social media. The objective of such action is to cause reputational damage to businesses. Finally, it is also observed that crucial to NGO power and influence is the collaboration with government and civil society organizations in the fight for environmental sustainability and accountability.

The novel COVID-19 pandemic prompted an unprecedented Institutional reaction to aggregate existing capacity from silos of research laboratories to establish a multidisciplinary research laboratory for COVID19 testing. In less than two weeks, resources were mobilized from the community to strengthen public health response and epidemic control. Such strengthening of institutional research capacity to support public health response contributes to a natural knowledge transfer, facilitates collaboration, and generates new frontiers for knowledge production that should ultimately lead to professional development and retention of skilled human resources. This report describes the pre-established mechanisms and involvement of the authors that made it possible to set-up a multidisciplinary laboratory in a remarkably short period of time. We also discuss the opportunities and sustainability of multidisciplinary laboratory research post-COVID19. Existing institutional capacity can be repurposed to establish multidisciplinary research laboratories to support the strengthening of basic and clinical translational research capacity in resource limited settings and impact on public health and scientific knowledge for socioeconomic development.

The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, has been declared by the World Health Organization (WHO) as a pandemic. Unfortunately, finding a vaccine or developing drugs from the scratch is a time-consuming luxury given the widespread and high fatality rates of the virus. In the short term, repurposing of drugs already in use seem to be the most rational step to quickly and effectively curb the virus. Several antiviral agents had been proposed as possible remedies, but the 4-aminoquinolines, Chloroquine (CHQ) and hydroxychloroquine (HCHQ) appear to be generating more interest. They are generic, cheaply available and have proven efficacy against malaria parasites in Africa. The human immunodeficiency virus (HIV), on the other hand, targets the immune system thereby reducing the patient’s ability to fight infections. Sadly, 68% of the global HIV burden occur in Africa. It is therefore anticipated that incidence of severe forms of COVID-19 could occur in Africa because of associated endemic conditions that compromise the immune system. With CHQ and HCHQ being considered for clinical use against COVID-19, there is a need to highlight their potential merits and confounding variables in the subgroup of patients with or without HIV.

The study sought to gauge the impact of COVID-19 pandemic in unleashing digital transformation in the education sector in South Africa. In order to gauge the impact, the study tracked the rate at which the 4IR tools were used by various institutions during the COVID-19 lockdown. Data were obtained from secondary sources, mainly newspaper articles, magazines and peer-reviewed journals. The findings are that, in South Africa, during the lockdown, a variety of 4IR tools were unleashed from primary education to higher and tertiary education where educational activities switched to remote learning (online learning). These observations point to the fact that South Africa generally has, some pockets of excellence to drive the education sector into the 4IR, which has the potential to increase access. Access to education, particularly at a higher education level, has always been a challenge due to a limited number of spaces available. Much as this pandemic has brought with it massive human suffering across the globe, there is an opportunity to assess successes and failures of deployed technologies, costs associated with them, and scaling these technologies to improve access.

South Africa possesses the largest anti-retroviral therapy (ART) program in the world but the path to this record was dramatic. There is scarce literature employing a comprehensive framework to explain this ART policy change and inform current policy making processes. This paper applies the Advocacy Coalition Framework (ACF) to analyse the interactions among diverse actors, institutions and networks that were associated with the ART policy change in South Africa. Post-apartheid, HIV/AIDS and AIDS-related mortality were serious public health problems. At the time, the discernible coalitions in the AIDS policy subsystem were the prescience coalition and AIDS dissidents. In view of the availability of compelling scientific evidence on the pathogenesis of HIV/AIDS, the clinical usefulness of ART, the availability of funding for national ART roll-out, strong global advocacy to reduce the cost of ART, all of these in an era when access to adequate HIV care was increasingly considered a human right, the environment to establish an appropriate ART policy for the country was conducive. However, AIDS dissidents dominated the policy agenda via their control over key institutions, the use of various dimensions of power, biasing evidence to inform policy, and promoting the activities of strong interest groups that were not in support of ART. National ART roll-out ultimately emerged as a political priority as a result of external shocks (on the ART policy subsystem) which disfavoured the dominant coalition. Failure to supplement this application of the ACF with key pubic policy concepts such as power dimensions, evidence use in policy, governance and emergence of global health networks would have led to suboptimal appraisal of the ART policy change and misinformation of current policy making processes.

The prevalence of congenital hearing impairment (HI) is highest in Africa. Estimates evaluated genetic causes to account for 31% of HI cases in Africa, but the identification of associated causative genes mutations have been challenging. In this study, we reviewed the potential roles, in humans, of 38 novel genes identified in a murine study. We gathered information from various genomic annotation databases and performed functional enrichment analysis using online resources i.e. genemania and g.proflier. Results revealed that 27/38 genes are express mostly in the brain, suggesting additional cognitive roles. Indeed, HERC1- R3250X had been associated with intellectual disability in a Moroccan family. A homozygous 216-bp deletion in KLC2 was found in two siblings of Egyptian descent with spastic paraplegia. Up to 27/38 murine genes have link to at least a disease, and the commonest mode of inheritance is autosomal recessive (n=8). Network analysis indicates that 20 other genes have intermediate and biological links to the novel genes, suggesting their possible roles in HI. This study will contribute to advance our knowledge in unravelling the biological roles of novel murine HI genes in humans and could enhance the understanding of the genetic causes of HI in Africans.

Improvements that can be attained in seasonal climate predictions in various parts of Africa using the multimodel supersensemble scheme are presented in this study. The synthetic superensemble (SSE) used follows the approach originally developed at Florida State University (FSU). The technique takes more advantage of the skill in the climate forecast data sets from atmosphere-ocean general circulation models running at many centres worldwide including the WMO global producing centers (GPCs). The module used in this work drew data sets from the Four versions of FSU coupled model system, seven models from the DEMETER project which is the forerun to the current European Ensembles Forecast System, the NCAR Model, and the Predictive Ocean Atmosphere Model for Australia (POAMA), all making a set of 13 individual models. An archive consisting of monthly simulations of precipitation was available over all the 5 regions of Africa, namely Eastern, Central, Northern, Southern, and Western Africa. The results showed that the SSE forecast for precipitation carries a higher skill compared to each of the member models and the ensemble mean. Relative to the ensemble mean (EM), the SSE provides an improvement of 18% in simulation of season cycle of precipitation climatology. In Eastern Africa, during December-February season, a north-south gradient of precipitation prevails between Tropical East Africa and the sector of the region towards Southern Africa. This regional scale climate pattern is a direct influence of the Intertropical Convergence Zone (ITZC) across the African continent during this time of the year. The SSE emerges with superior skill scores such as lowest root mean square error above the EM and the member models, for example in the prediction of spatial location and precipitation magnitudes that characterize the see-saw precipitation pattern in Eastern Africa. In all parts of Africa, and especially Eastern Africa where seasonal precipitation variability is a frequent cause huge human suffering in due to droughts and famine, the multimodel superensemble and its subsequent improvements will always provide a forecast that out weighs the best Atmosphere-Ocean Climate Model.

This paper contributes to the understating of tornadoes in South Africa using case study analysis. In South Africa tornadoes are the recurring phenomenon (the climatology) but so far they have received less attention. Damages from storms itself (tornadoes inclusive) are significant in South Africa relative to other weather-related disasters for example floods, heat waves, and droughts. For their understanding, a case study approach was adopted in the current study. Data were in courtesy of the following, National Oceanic and Atmospheric Administration (NOAA), National Centers for Environmental Predictions (NCEP), Eumetsat Germany, and South African Weather Service (SAWS). The aim of the study was to provide an overview of the occurrence of tornadoes in South Africa using a Klerksdorp tornado, which occurred on March 4, 2007, Northwest Province in South Africa. From the case study analysis, the tornado was associated with the cold front and cut-off low (both are extratropical circulation) which were the dominant weather systems of the day. Therefore we conclude that, a case study approach may be the best way to study events of these nature for a more informed decision, for example, issuing an early warning system. In future, case studies, for example, involving interaction between extratropical and tropical circulation will also be an interesting study.

This commentary is focused on radioactive contaminations in the Urals, where the consequences were more severe in the long term than those after the Chernobyl accident. The difference is that the latter was a technogenic catastrophe, but the former - a radioactive contamination tolerated since 70 years with several accidents in between. In earlier publications of Russian researchers no cancer frequency elevation was reported after exposures below 0.5 Sv or generally in the populations exposed to low doses. Later on, the same scientists started to claim similar relative risks for cancer and other diseases among exposed people in the Urals and in atomic bomb survivors from Hiroshima and Nagasaki. Apparently, an unofficial directive has been behind this ideological shift noticed around the year 2005. Trimming of statistics has been not unusual in the former Soviet Union. Potential motives included fostering radiophobia, stirring anti-nuclear protests in other countries and strangulation of nuclear energy aimed at the boosting of fossil fuel prices. Recent publications claiming cardiovascular risks after low-dose low-rate exposures and recommending more stringent standards of radiological protection are discussed here in some detail. Such recommendations for dose rates compatible with the natural radiation background are obviously nonsensical.

Target 9.c of the 2015 United Nations (UN) sustainable development goals (SDGs) specifically addresses increasing access to information and communication technology (ICT) resources, and striving for universal access to the internet by 2020. The present study seeks to evaluate the effectiveness of the youth related national strategies implemented in this regard by a select number of countries in the Middle East region. The study does so, by relying on a spatial bivariate copula regression analysis of data on youth respondents from five countries, extracted from the 2018 Program for international students’ assessment (PISA). Focusing specifically on evaluating the availability of ICT resources to the youth population, and also identifying the impact of ICT resources on youth subjective well-being in the region, we find that except for the UAE and Qatar that have above OECD average youth performance on the ICT resource index, youth from the remaining countries reported below OECD level average access to ICT resources. The within region cross-country comparative analysis of ICT resources availability to the youth population at home, also highlighted significant heterogeneity across the five countries, post 2015 SDG adoption by UN country members. Furthermore, looking at the impact of ICT resources on youth well-being, controlling for not only cross-country spatial correlations, and factors such as home educational resources, cultural possessions at home, parental occupation status, youth expected occupation status, economic and socio-cultural status, age, gender, and grade level in school; we found that every standard deviation increase in ICT resources to the youth population in the region raises their self-expressed sense of belonging in school by 1.88% standard deviations. Given the empowering nature of ICT resources to youth, and the potential of both to support national as well as regional economic development initiatives, a concerted effort to ease ICT resources diffusion by member countries in the middle east region could assist not only each country in its own development path, but also the region as a whole to live up to its growth potential by the 2030.

Scrub typhus is a life-threatening infectious disease and always creating a diagnostic dilemma in terms of rapid turnaround time and accuracy, qRT PCR can become a very good option to achieve the desired result with the molecular level of accuracy and boost up the rapid patient management. This study was performed to evaluate the performance of qRT PCR in comparison to commonly used IgM ELISA and Weil-Felix tests to diagnose scrub typhus, as well as to look for the demographic and clinical profile of the disease in North-East India. It was a hospital-based prospective study conducted in a tertiary care hospital of north-east India, over a period of 1 year, in which all the samples from suspected scrub typhus cases were screened by Weil-Felix test as per institute’s diagnostic protocol after which IgM ELISA for Scrub Typhus was performed. All the IgM positive samples and 20 highly suspected but ELISA negative samples were subjected to qRT PCR, targeting 56 kDa type-specific gene of O. tsutsugamushi. Statistical analysis was done by MS-Excel for Windows v2013® and MedCalc® v17.9 for Windows (MedCalc Software, Acacialaan 22, B-8400 Ostend, Belgium). In this study, we have successfully evaluated the performance of qRT PCR kit for diagnosis of scrub typhus. Out of 54 samples tested, 24 IgM ELISA positive samples and 3 IgM ELISA negative samples have shown the presence of bacterial DNA with quantification of DNA copies. It has also been observed that 21 out of 27 PCR positive samples (77.8%) were detected within the 1st 7 days of illness. All the demographic, as well as clinical data, were also analysed. The performance of the commercial qRT PCR kit used in our study is satisfactory, which provides the extra advantage of quantification of DNA copies and increases diagnostic accuracy within the 1st week of fever.

Organic farming has positive, impact on environment, soil health, and healthy food quality. Worldwide demand for organic foods is increasing by leaps and bounds in recent years. The present investigation was undertaken during 2014 to 2018 to evaluate the effect of cowpea (Vigna unguiculata) co-culture with maize (Zea mays L.) on productivity enhancement over prevailing maize-fallow system, and to assess the feasibility of inclusion of short duration winter crops after maize with appropriate residue management practices on productivity and soil health. The experiment comprised of six cropping systems in main plot and three soil moisture conservation (SMC) measures options in sub plot. Results indicated that the inclusion of second crop in place of fallow and cowpea co-culture with maize increased average maize grain yield by 6.2 to 23.5% as compared to that of maize-fallow (MF). Use of maize stover mulch (MSM) + weed biomass mulch (WBM) increases maize grain yield by 19.1 and 6.5% over those of MSM and no mulch (NM), respectively. Various soil moisture conservation (SMC) measures had significant (p=0.05) effect on crop yields and water productivity. Double cropping system had significantly (p=0.05) higher amount of soil available NPK, soil organic carbon (SOC), microbial biomass carbon (MBC) and dehydrogenase activity (DHA) at 0-15 cm and at 15-30 cm depth than those under MF. The SWC measures of MSM+WBM had significantly higher available N, SOC, and MBC by 5.5, 4.8 and 8.1% than those under NM, respectively. Correspondingly, soils under MSM and MSM+WBM had 2.24 and 2.99% lower bulk density (ρb) in 0-15 cm and 2.21 and 2.94% lower ρb in 15-30 cm than that of NM. The energy use efficiency (EUE) was significantly higher under MCV (7.90%) over rest of the cropping sequences. MSM+WBM and MSM recorded 25.1 and 16.6% higher net energy over NM, respectively. The net return (INR 159.99×103/ha) and B:C ratio (2.86) were significantly higher with MCV system followed by MCR cropping sequence. MSM+WBM had significantly higher net return (INR 109.44×103/h), B:C ratio (2.46) over those under MSM (INR 97.6×103/h) and NM (INR 78.61×103/h). Overall the cowpea co-culture with maize and inclusion of short cycle winter crops along with MSM+WBM in maize-based cropping systems was found productive in terms of crop and water, profitable, energy efficient and sustained the soil health.