Version 1
: Received: 13 April 2023 / Approved: 14 April 2023 / Online: 14 April 2023 (03:30:46 CEST)
How to cite:
Mvandal, S.P.; Mlonganile, W. Unraveling the Hidden Impact of Tumor Microenvironment: Insights into Novel Therapeutic Strategies for Oncology in Tanzania: Integrated Review. Preprints2023, 2023040340. https://doi.org/10.20944/preprints202304.0340.v1
Mvandal, S.P.; Mlonganile, W. Unraveling the Hidden Impact of Tumor Microenvironment: Insights into Novel Therapeutic Strategies for Oncology in Tanzania: Integrated Review. Preprints 2023, 2023040340. https://doi.org/10.20944/preprints202304.0340.v1
Mvandal, S.P.; Mlonganile, W. Unraveling the Hidden Impact of Tumor Microenvironment: Insights into Novel Therapeutic Strategies for Oncology in Tanzania: Integrated Review. Preprints2023, 2023040340. https://doi.org/10.20944/preprints202304.0340.v1
APA Style
Mvandal, S.P., & Mlonganile, W. (2023). Unraveling the Hidden Impact of Tumor Microenvironment: Insights into Novel Therapeutic Strategies for Oncology in Tanzania: Integrated Review. Preprints. https://doi.org/10.20944/preprints202304.0340.v1
Chicago/Turabian Style
Mvandal, S.P. and Wende Mlonganile. 2023 "Unraveling the Hidden Impact of Tumor Microenvironment: Insights into Novel Therapeutic Strategies for Oncology in Tanzania: Integrated Review" Preprints. https://doi.org/10.20944/preprints202304.0340.v1
Abstract
The tumor microenvironment (TME) plays a critical role in cancer progression and treatment outcomes. Despite advances in cancer research, many therapeutic strategies have failed to provide the desired clinical outcomes. In this integrated review, aimed to explore the role of TME in cancer biology and develop novel therapeutic strategies that target not only cancer cells but also the surrounding microenvironment. Study conducted a comprehensive literature search using PubMed, Embase, and Web of Science databases for articles published between 2016 and 2022. Inclusion of articles that discussed the impact of TME on cancer development and progression, as well as articles that proposed novel therapeutic strategies targeting the TME. The analysis of the literature revealed that the TME plays a crucial role in cancer development and progression by promoting cancer cell survival, angiogenesis, invasion, and metastasis, and by interfering with the efficacy of cancer therapies. The TME is composed of a complex network of non-cancerous cells, extracellular matrix components, and signaling molecules that interact with cancer cells. Several novel therapeutic strategies have been proposed based on the modulation of TME components. One of the most promising approaches is the use of immunotherapy, which aims to enhance the immune system's ability to recognize and attack cancer cells. Immunotherapy drugs such as checkpoint inhibitors, chimeric antigen receptor (CAR) T cells, and immune-stimulatory monoclonal antibodies have been approved for the treatment of different cancer types. These approaches have shown promising results in preclinical studies and clinical trials. The TME plays a critical role in cancer development and progression, and targeting its components represents a promising avenue for cancer therapy. Novel therapeutic strategies such as immunotherapy, extracellular matrix-targeting drugs, and nanoparticle-based therapies have shown promising results in preclinical studies and clinical trials. However, further research is needed to identify the most effective strategies and to overcome the challenges associated with TME targeting.
Medicine and Pharmacology, Oncology and Oncogenics
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
