Version 1
: Received: 15 October 2018 / Approved: 16 October 2018 / Online: 16 October 2018 (15:43:55 CEST)
How to cite:
Al-Imam, A. A Demographic and Biochemical Analytic of Cases of G6PD Deficiency:
A Cross-Sectional Study from the Middle East. Preprints2018, 2018100366. https://doi.org/10.20944/preprints201810.0366.v1
Al-Imam, A. A Demographic and Biochemical Analytic of Cases of G6PD Deficiency:
A Cross-Sectional Study from the Middle East. Preprints 2018, 2018100366. https://doi.org/10.20944/preprints201810.0366.v1
Al-Imam, A. A Demographic and Biochemical Analytic of Cases of G6PD Deficiency:
A Cross-Sectional Study from the Middle East. Preprints2018, 2018100366. https://doi.org/10.20944/preprints201810.0366.v1
APA Style
Al-Imam, A. (2018). A Demographic and Biochemical Analytic of Cases of G6PD Deficiency:
A Cross-Sectional Study from the Middle East. Preprints. https://doi.org/10.20944/preprints201810.0366.v1
Chicago/Turabian Style
Al-Imam, A. 2018 "A Demographic and Biochemical Analytic of Cases of G6PD Deficiency:
A Cross-Sectional Study from the Middle East" Preprints. https://doi.org/10.20944/preprints201810.0366.v1
Abstract
BACKGROUND
G6PD deficiency is an inherited an X-linked recessive condition leading to insufficient levels of glucose-6-phosphate dehydrogenase, thus causing hemolytic anaemia under certain conditions.
METHODS
Our study is explorative for cases admitted to Jordan University Hospital. The studied parameters include demographics, clinical manifestations, biochemical markers including Hb level, WBC count, liver enzymes, and blood grouping.
RESULTS
Most of the patients were admitted to the emergency unit (53.13%). Individuals who were Rh-positive represented 57.81%, while patients of AB blood group accounted for 75%. The mean values were 4.81 years (age), 29.06 hours (time-to-hospital admission), 38.10 degree Celsius (temperature), 6.11 gm/dl (Hb), 13242.19 (WBC count), 343.20 U/L (S. ALP), and 50.98 IU/L (S. ALT). There was no significant difference between males and females or between favism-induced versus drug-induced hemolytic episodes. AB and Rh positive blood groups are of protective effect in relation to liver enzymes. Patients who were admitted to the hospital within 24 hours from having clinical manifestations had a better prognosis.
CONCLUSION
This study is the first inferential research on G6PD deficiency from the Middle East to explore cases from one of the largest healthcare centres in Jordan. The role of blood grouping should be investigated prospectively.
Medicine and Pharmacology, Pediatrics, Perinatology and Child Health
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
