Preprint Article Version 1 This version is not peer-reviewed

A Demographic and Biochemical Analytic of Cases of G6PD Deficiency: A Cross-Sectional Study from the Middle East

Version 1 : Received: 15 October 2018 / Approved: 16 October 2018 / Online: 16 October 2018 (15:43:55 CEST)

How to cite: Al-Imam, A. A Demographic and Biochemical Analytic of Cases of G6PD Deficiency: A Cross-Sectional Study from the Middle East. Preprints 2018, 2018100366 (doi: 10.20944/preprints201810.0366.v1). Al-Imam, A. A Demographic and Biochemical Analytic of Cases of G6PD Deficiency: A Cross-Sectional Study from the Middle East. Preprints 2018, 2018100366 (doi: 10.20944/preprints201810.0366.v1).

Abstract

BACKGROUND G6PD deficiency is an inherited an X-linked recessive condition leading to insufficient levels of glucose-6-phosphate dehydrogenase, thus causing hemolytic anaemia under certain conditions. METHODS Our study is explorative for cases admitted to Jordan University Hospital. The studied parameters include demographics, clinical manifestations, biochemical markers including Hb level, WBC count, liver enzymes, and blood grouping. RESULTS Most of the patients were admitted to the emergency unit (53.13%). Individuals who were Rh-positive represented 57.81%, while patients of AB blood group accounted for 75%. The mean values were 4.81 years (age), 29.06 hours (time-to-hospital admission), 38.10 degree Celsius (temperature), 6.11 gm/dl (Hb), 13242.19 (WBC count), 343.20 U/L (S. ALP), and 50.98 IU/L (S. ALT). There was no significant difference between males and females or between favism-induced versus drug-induced hemolytic episodes. AB and Rh positive blood groups are of protective effect in relation to liver enzymes. Patients who were admitted to the hospital within 24 hours from having clinical manifestations had a better prognosis. CONCLUSION This study is the first inferential research on G6PD deficiency from the Middle East to explore cases from one of the largest healthcare centres in Jordan. The role of blood grouping should be investigated prospectively.

Subject Areas

Glucosephosphate Dehydrogenase Deficiency; G6PD; ABO Blood-Group System; Middle East; Arabs.

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