Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases

Nyarai Desiree Soko
* ORCID logo ,
Sarudzai Muyambo
ORCID logo ,
Michelle T.L. Dandara
,
Elizabeth Kampira
,
Dirk Blom
,
Erika S.W Jones
,
Brian Rayner
ORCID logo ,
Delva Shamley
ORCID logo ,
Phumla Sinxadi
,
Collet Dandara
* ORCID logo
Version 1 : Received: 14 June 2023 / Approved: 15 June 2023 / Online: 15 June 2023 (12:33:17 CEST)

A peer-reviewed article of this Preprint also exists.

Soko, N.D.; Muyambo, S.; Dandara, M.T.L.; Kampira, E.; Blom, D.; Jones, E.S.W.; Rayner, B.; Shamley, D.; Sinxadi, P.; Dandara, C. Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases. J. Pers. Med. 2023, 13, 1185. Soko, N.D.; Muyambo, S.; Dandara, M.T.L.; Kampira, E.; Blom, D.; Jones, E.S.W.; Rayner, B.; Shamley, D.; Sinxadi, P.; Dandara, C. Towards Evidence-Based Implementation of Pharmacogenomics in Southern Africa: Comorbidities and Polypharmacy Profiles across Diseases. J. Pers. Med. 2023, 13, 1185.

Abstract

Pharmacogenomics may improve patient care by guiding drug selection and dosing, however this requires prior knowledge of the pharmacogenomics of drugs commonly used in a specific setting. The aim of this study was to identify a preliminary set of pharmacogenetic variants important in Southern Africa. We describe co-morbidities in 3997 patients from Malawi, South Africa, and Zimbabwe. These patient cohorts were included in pharmacogenomic studies of anticoagulation, dyslipidemia, hypertension, HIV, and breast cancer. The 20 topmost prescribed drugs in this population were identified. Using literature, a list of pharmacogenes vital in disposition of the top 20 drugs was constructed leading to drug-gene pairs potentially informative in translation of pharmacogenomics. The most reported morbidity was hypertension (58.4%), making antihypertensives the most prescribed drugs, particularly amlodipine. Dyslipidemia occurred in 31.5% of the participants and statins were frequently prescribed cholesterol lowering drugs. HIV was reported in 20.3% of the study participants with lamivudine/stavudine/efavirenz being the most prescribed antiretroviral combination. Based on these data, pharmacogenes of immediate interest in Southern African populations include ABCB1, CYP2B6, CYP2C9, CYP2C19, CYP2D6, CYP3A4, CYP3A5, SLC22A1, SLCO1B1 and UGT1A1. Variants in these genes are a good starting point for pharmacogenomic translation programs in Southern Africa.

Keywords

pharmacogenomics; translation; Africa; comorbidities; clinical

Subject

Medicine and Pharmacology, Medicine and Pharmacology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Download PDF

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our Diversity statement.

Leave a public comment
Send a private comment to the author(s)
* All users must log in before leaving a comment
Views 0
Downloads 0
Comments 0
Metrics 0
Get PDF Cite Share 0
Bookmark BibSonomy Mendeley Reddit Delicious
×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.
We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.