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Preprint REVIEW | doi:10.20944/preprints202409.1408.v1

Extrarenal Visceral Arteries Injuries During Left Radical Nephrectomy: A 50-Year Continuing Problem

Marco Catarci, Leonardo Antonio Montemurro, Michele Benedetti, Paolo Ciano, Massimiliano Millarelli, Roberto Chiappa

Subject: Surgery, Medicine And Pharmacology Keywords: Superior mesenteric artery injuries; celiac trunk injuries; left radical nephrectomy

Online: 19 September 2024 (03:19:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0236.v2

God’s Certainty-Uncertainty Principle versus Heisenberg’s Uncertainty Principle: A Possible Path to Unification of Gravity and Quantum Mechanics

Espen Haug

Subject: Theoretical Physics, Physical Sciences Keywords: Heisenberg’ s uncertainty principle; general relativity; quantum gravity; quantum mechanics; Compton wavelength; de Broglie wavelength; Planck scale

Online: 19 September 2024 (03:17:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1205.v2

How Does the Threshold for Urban Household Registration in China Affect the Willingness of Rural to Urban Migrant Population to Settle Down?

Qian qian ZHANG, Li feng Su, Chao fan An

Subject: Business, Economics And Management, Economics Keywords: threshold for urban household registration; Rural urban migrant population's willingness to settle down; IV estimation

Online: 18 September 2024 (23:51:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1451.v1

Toward a Comprehensive Economic Comparison Framework for Solar Projects: A Case Study of Utility and Residential Scales

Bowen He, Han Zheng, Qixiao Zhang, Yayan Zhao, Huaizhi Tang, Ping Xi, Laiwei Wei, Muqing Li, Qun Guan

Subject: Energy And Fuel Technology, Engineering Keywords: Utility Solar Farms; Cost-Benefit Analysis; Economic Analysis; Life Cycle Approach; Battery Energy Storage System (BESS); Grid-tie Residential Solar Systems

Online: 18 September 2024 (16:43:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1448.v1

Multi-Sensor Soil Probe and Machine Learning Modeling

Sabine Grunwald, MOF Murad, Stephen Farrington, Woody Wallace, Daniel Rooney

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: digital twin, digital soil mapping, soil sensors, multi-sensor system, digital soil core, machine learning, artificial intelligence, soil properties, scale

Online: 18 September 2024 (15:49:20 CEST)

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We present a data-driven, in situ proximal multi-sensor digital soil mapping approach to develop digital twins for multiple agricultural fields. A novel Digital Soil CoreTM (DSC) Probe was engineered that contains seven sensors, each of a distinct modality, including sleeve friction, tip force, dielectric permittivity, electrical resistivity, soil imagery, acoustics, and visible and near-infrared spectroscopy. The DSC System integrates components the DSC Probe, DSC software, and deployment equipment to sense soil characteristics at a high vertical spatial resolution (mm scale) along in situ soil profiles up to a depth of 120 cm in about 60 sec. The DSC Probe in situ proximal data are harmonized into a data cube providing vertical high-density knowledge associated with physical-chemical-biological soil conditions. In contrast, conventional ex situ soil samples derived from soil cores, soil pits, or surface samples analyzed using laboratory and other methods are bound by substantially coarser spatial resolution and multiple compounding errors. Our objective was to investigate the effects of mismatched scale between high-resolution in situ proximal sensor data and coarser resolution ex situ soil laboratory measurements to develop soil prediction models. Our study was conducted in central California soil in almond orchards. We collected DSC sensor data and spatially co-located soil cores that were sliced into narrow layers for laboratory-based soil measurements. Partial Least Squares Regression (PLSR) cross-validation was used to compare results testing four data integration methods. Method A reduced the high-resolution sensor data to discrete values paired with layer-based soil laboratory measurements. Method B used stochastic distributions of sensor data paired with layer-based soil laboratory measurements. Method C allocated the same soil analytical data to each one of the high-resolution multi-sensor data within a soil layer. Method D linked the high-density multi-sensor soil data directly to crop responses (crop performance and behavior metrics) bypassing costly laboratory soil analysis. Overall, the soil models derived from Method C outperformed Methods A and B. Soil predictions derived using Method D were most cost-effective for directly assessing soil-crop relationships, making this method well-suited for industrial-scale precision agriculture applications.

Preprint ARTICLE | doi:10.20944/preprints202409.1427.v1

Chiral Sodium Glicerophosphate Catalyst for Enantioselective Michael Reactions of Chalcones

Giovanni Ghigo, Julia Rivella, Alessio Robiolio Bose, Stefano Dughera

Subject: Organic Chemistry, Chemistry And Materials Science Keywords: conjugate addition; organocatalyst; chiral catalyst

Online: 18 September 2024 (15:34:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1441.v1

Evolution Of Self-gravitating Fluid Spheres Involving Ghost Stars

Luis Herrera, Alicia Di Prisco, Justo Ospino

Subject: Theoretical Physics, Physical Sciences Keywords: Relativistic fluids; interior solutions; spherically symmetric sources

Online: 18 September 2024 (15:32:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1425.v1

Racial, Ethnic, and Socioeconomic Disparities in Access to Critical Procedures in Patients Hospitalized with Cirrhosis Complications

Miriam M. Sanchez, Chris A. Sabillon, Thomas G. Cotter, Marlyn J. Mayo, Kevin A. Sanchez, Chukwuma Egwim, Anunaya Aashish

Subject: Gastroenterology And Hepatology, Medicine And Pharmacology Keywords: Decompensated Cirrhosis; Portal Hypertension; Health Disparities; Hepatology; TIPS; EGD; Liver transplantation

Online: 18 September 2024 (15:30:12 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1424.v1

’Seeing is Believing’: How Neutron Crystallography Informs Enzyme Mechanism by Visualizing Unique Water Species

Qun Wan, Brad C. Bennett

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: neutron diffraction; deuterium; hydronium; protein structure; enzyme catalysis; H/D exchange

Online: 18 September 2024 (15:28:49 CEST)

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Hydrogen is the lightest atom and composes roughly half of the atomic content in macromolecules, yet their location can only be inferred or predicted in most macromolecular structures. This is because hydrogen can rarely be directly observed by the most common structure determination techniques (such as X-ray crystallography and electron cryo-microscopy). However, knowledge of hydrogen atom positions, especially for enzymes, can reveal protonation states of titratable active site residues, hydrogen bonding patterns, and the orientation of water molecules. Though we know they are present, this vital layer of information, which can inform a myriad of biological processes, is frustratingly invisible to us. The good news is that, even at modest resolution, neutron crystallography (NC) can reveal this layer and has emerged this century as a powerful tool for elucidating enzyme catalytic mechanisms. Due to its strong and coherent scattering of neutrons, incorporation of deuterium into the protein crystal amplifies the power of NC. This is especially true when solvation and the specific participation of key water molecules are crucial for catalysis. Neutron data allow the modeling of all three atoms in water molecules and have even revealed previously unobserved and unique species such as hydronium (D3O+) and deuteroxide (OD-) ions as well as lone deuterons (D+). Herein, we briefly review why neutrons are ideal probes for identifying catalytically important water molecules and these unique water-like species, limitations in interpretation, and four vignettes of enzyme success stories from disparate research groups. One of these groups was that of Dr. Chris G. Dealwis, who died unexpectedly in 2022. As a memorial appreciation of his scientific career, we will also highlight his interest and contributions to the neutron crystallography field. As both the authors were mentored by Chris, we feel we have a unique perspective on his love of molecular structure and admiration for neutrons as a tool to query those structures.

Preprint ARTICLE | doi:10.20944/preprints202409.1437.v1

Leveraging Innovation Capability and Organizational Resilience to Business Sustainability Among Small and Medium Enterprises: A PLS-SEM Approach

Banji Rildwan Olaleye, Joseph Nembo Lekunze, Tsediso Joseph Sekhampu, Ntseliseng Khumalo, Adebanji Adejuwon William Ayeni

Subject: Business And Management, Business, Economics And Management Keywords: Business sustainability; Environmental dynamism; Innovation capability; Organizational resilience; PLS-SEM; Sustainable competitive advantage; SMEs

Online: 18 September 2024 (15:27:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1422.v1

Accelerating Wound Repair: The Multifaceted Role of Mesenchymal Stem Cells

Abdul Ghani NI, Nurhidayatul MN, Khairul AK, Hasmad HN, Afifa NT, Helmi BS, Aida Juliana AJ, Farisha MN, Balqish MR, Chua KH, BiiChau T, Shamsul BS

Subject: Life Sciences, Biology And Life Sciences Keywords: Mesenchymal Stem Cells (MSCs); Paracrine mechanism; Growth factors; Chronic wounds; Secretome

Online: 18 September 2024 (15:24:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1444.v1

Impaired Development of Collagen Antibody-Induced Arthritis in Rab44-Deficient Mice

Yu Yamaguchi, Tomoko Kadowaki, Eiko Sakai, Mayuko Noguromi, Shun Oyakawa, Takayuki Tsukuba

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: Rab44; collagen antibody-induced arthritis; immune cells; osteoclasts

Online: 18 September 2024 (15:11:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1445.v1

Dissolved Hydrogen Concentration in the Psychrophilic Anaerobic Digestion of Food Leftovers and Its Correlation to VFA/ TIC Ratio

Daniela Platosova, Jiri Rusin, Radek Svoboda, Katerina Smutna

Subject: Environmental Science, Environmental And Earth Sciences Keywords: anaerobic digestion; fermentation; psychrophilic bioreactor; dissolved hydrogen; amperometric sensor

Online: 18 September 2024 (15:10:08 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202409.1432.v1

Hypothesis: Search for Sources of Systematic Error in Astrometric Measurements of the Cosmological Constant

Michael Overholt

Subject: Physical Sciences, Astronomy And Astrophysics Keywords: Lambda-CDM; dark energy; cosmological constant; Hubble Tension

Online: 18 September 2024 (14:59:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1435.v1

Organizational Resilience Opacity in the Prism of Circular Strategy – Metal Industry Manufacturing Practice

Sławomir Zapłata, Magdalena Muradin, Patryk Feliczek, Joanna Katarzyna Banach, Kacper Sieciński

Subject: Business And Management, Business, Economics And Management Keywords: organizational resilience; circular strategy; circular economy; metal industry manufacturing

Online: 18 September 2024 (14:29:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1439.v1

Global Trends in Breast Cancer Research: A Bibliometric Analysis from the Scopus Database (2014–2023)

Vishwas Hase, Ahirrao Manjusha

Subject: Library And Information Sciences, Social Sciences Keywords: Brest Cancer; Scientometrics; Bibliometrics; Cancer; Scopus

Online: 18 September 2024 (14:26:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1438.v1

Importance of Lactobacilli for Human Health

Piotr B. Heczko, Milena Giemza, Weronika Ponikiewska, Magdalena Strus

Subject: Dietetics And Nutrition, Medicine And Pharmacology Keywords: Lactobacillus, gut- vaginal- microbiota, neonates, innate immunity

Online: 18 September 2024 (14:19:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1430.v1

Preclinical evaluation of Electronic Health Records (EHR) to predict poor control of chronic respiratory diseases in primary care: a novel approach to focus our efforts

Fernando M. Navarro i Ros, José David Maya Viejo

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: ; asthma; COPD; electronic health records; clinical predictors; primary care ;

Online: 18 September 2024 (14:05:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1426.v1

Improving the Efficiency and Safety of Sentinel Stink Bug Eggs Using X-Rays

Evelyne Hougardy, Ronald P. Haff, Brian N. Hogg

Subject: Insect Science, Biology And Life Sciences Keywords: stink bug; egg parasitism; field monitoring; sentinel eggs; x-ray irradiation; egg sterilization

Online: 18 September 2024 (13:57:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1415.v1

Technological Interface Components that Support Accelerated ‎Learning in the Acquisition of Foreign Language Vocabulary

David Passig, Ganit Eshel-Kedmi, Adi Aharoni

Subject: Education, Social Sciences Keywords: Accelerated learning; Acquisition of a foreign language; Luznov model; ‎CALL; VR learning environment

Online: 18 September 2024 (13:40:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2167.v2

Evaluation of Compliance and Accuracy in Parkinson's Disease Motor Symptom Tracking: A Comparative Study of Digital and Traditional Paper Diaries Using a Smartphone Application (My Parkinson’s)

Nazlı Durmaz Çelik, Aslı Yaman Kula, Naci Murat, Müge Kuzu Kumcu, Aydan Topal, Serhat Özkan

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Parkinson’ s Disease; Mobile Applications; Parkinson’ s disease digital diary

Online: 18 September 2024 (13:40:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1413.v1

Sodium, Potassium Adenosine Triphosphatase as a Potential Target of the Anti-Tuberculosis Agents, Clofazimine and Bedaquiline

Khomotso Mmakola, Helen Steel, Mohamed Said, Moliehi Potjo, Mieke van der Mescht, Nomsa Hlatshwayo, Pieter Meyer, Gregory Tintinger, Ronald Anderson, Moloko Cholo

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: Bedaquiline; clofazimine; cardiomyocytes; cellular viability; multidrug-resistant-tuberculosis; sodium, potassium-adenosine triphosphatase; adenosine triphosphate

Online: 18 September 2024 (13:05:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1416.v1

Cultivating Health: Advancing Medicinal Plant Management Strategies in Iraq

Mahir Essa Jumaa Alsalahi

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: Traditional Medicine; Mesopotamian Civilization; Biodiversity; Ethno botany; Environmental Challenges; Herbal Remedies; Plant Compounds; International Trade

Online: 18 September 2024 (13:04:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1411.v1

Relationship Between Condylar and Ramal Asymmetries and ABO and RH Blood Groups: A Pilot Study

Mehmet Emrah Polat, Halil Ibrahim Durmus, Mehmet Gül

Subject: Dentistry And Oral Surgery, Medicine And Pharmacology Keywords: Blood groups; Condylar Asymmetry; Ramal Asymmetry

Online: 18 September 2024 (13:03:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1414.v1

Design Methods of Aluminium Pin-Ended Columns with Topology Optimised Cross Sections

Mehmet A Güler, Aykut Artac, Bora Yildirim, Konstantinos Daniel Tsavdaridis

Subject: Civil Engineering, Engineering Keywords: aluminium, columns, FE analysis, topology optimisation, DSM, CSM

Online: 18 September 2024 (12:56:11 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202409.1406.v1

Advances in Compounds Targeting Regulatory Mechanisms of Biofilm Formation in Unicellular Eukaryotes: Insights from 2024 Research and Applications in Vietnam

Dang Anh Tuan, Pham Vu Nhat Uyen, Jan Masak

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: biofilm formation; quorum sensing inhibitors; cyclic di-GMP; betulinic acid; pulmonarin B analogues; antimicrobial resistance; unicellular eukaryotes; Vietnam

Online: 18 September 2024 (12:50:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1405.v1

Estimation Network for Multiple Chemical Parameters of Astragalus Leaves Based on Attention Mechanism and Multivariate Hyperspectral Features

Yulong Zhou, Zhiyun Xiao, Tengfei Bao, Tao Fang

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: Astragalus membranaceus var. mongholicus; Chemical parameters; Hyperspectral estimation; Attention mechanism; Deep network

Online: 18 September 2024 (12:47:49 CEST)

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In the context of smart agriculture, accurately estimating plant leaf chemical parameters is crucial for optimizing crop management and improving agricultural yield. Hyperspectral imaging, with its ability to capture detailed spectral information across various wavelengths, has emerged as a powerful tool in this regard. However, the complex and high-dimensional nature of hyperspectral data poses significant challenges in extracting meaningful features for precise estimation. To address this challenge, this study proposes an end-to-end estimation network for multiple chemical parameters of Astragalus leaves based on attention mechanism (AM) and multivariate hyperspectral features (AM-MHENet). We leveraging HybridSN and multilayer perception (MLP) to extract prominent features from the hyperspectral data of Astragalus membranaceus var. mongholicus (AMM) leaves and stems, as well as the surface and deep soil surrounding AMM roots. This methodology allows us to capture the most significant characteristics present in these hyperspectral data with high precision. The AM is subsequently used to assign weights and integrate the hyperspectral features extracted from different parts of the AMM. The MLP is then employed to simultaneously estimate the chlorophyll content (CC) and nitrogen content (NC) of AMM leaves. Compared with estimation networks that utilize only hyperspectral data from AMM leaves as input, our proposed end-to-end AM-MHENet demonstrates superior estimation performance. Specifically, AM-MHENet achieves an R2 of 0.983 with an RMSE of 0.73 for the estimation of CC in AMM leaves. For NC estimation, AM-MHENet achieves an R2 value of 0.977 with an RMSE of 0.27. These results underscore AM-MHENet’s effectiveness in significantly enhancing the accuracy of both CC and NC estimation in AMM leaves. Moreover, these findings indirectly suggest a strong correlation between the development of AMM leaves and stems, as well as the surface and deep soil surrounding the roots of AMM, and directly highlight the ability of AM to effectively focus on the relevant spectral features within the hyperspectral data. This findings from this study could offer valuable insights into the simultaneous estimation of multiple chemical parameters in plants, thereby making a contribution to the existing body of research in this field.

Preprint ARTICLE | doi:10.20944/preprints202409.1403.v1

Recommendation to Solve the Difference in Performance Management between Civil Servant in Timor-Leste

Cristovao de Alexandria Barros

Subject: Human Resources And Organizations, Business, Economics And Management Keywords: performance management; public management; public policy; civil servant; Timor-Leste civil servant

Online: 18 September 2024 (12:44:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1404.v1

The Impact of the Lighting Regimen and Feeding Program during Rearing on Hy-Line Brown Pullets at the End of Rearing and, During Early Lay

Wendy Isabelle Muir, Yeasmin Akter, Sebastian K.Y. Kho, Kenneth Bruerton, Peter John Groves

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: food restriction; reduced lighting; egg quality; egg production; body weight; feed intake; age of first egg; growth; photoperiod

Online: 18 September 2024 (12:43:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1402.v1

Histological Findings of Resected Tracheal Ring in SARS-CoV-2 Positive and Negative Tracheostomized Patients

Nieves Mata-Castro, Raul Castañeda Vozmediano, Cristian Perna, Carlos Prada, Lorena Sanz López

Subject: Otolaryngology, Medicine And Pharmacology Keywords: tracheostomy; COVID-19; SARS-CoV-2; histopathology

Online: 18 September 2024 (12:39:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1396.v1

Search for True Ternary Fission in the Reaction ⁴⁰Ar+²⁰⁸Pb

Md Ashaduzzaman, Antonio Di Nitto, Emanuele Vardaci, Giovanni La Rana, Pia Antonella Setaro, Tathagata Banerjee, Antonio Vanzanella, Giuseppe Alifano

Subject: Nuclear And High Energy Physics, Physical Sciences Keywords: Ternary Fission; Fusion-fission reactions; Heavy ions; Spectrometers for nuclear physics

Online: 18 September 2024 (12:37:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1362.v1

Prolonged Visual Evoked Potential Latencies in Dogs Naturally Infected with Canine Distemper Virus

Mary Gutiérrez, Luis Delucchi, Alejandro Bielli, José Manuel Verdes

Subject: Veterinary Medicine, Medicine And Pharmacology Keywords: canine distemper virus; dogs; electrophysiology; increased latency; veterinary neurology; visual evoked potentials

Online: 18 September 2024 (12:34:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1358.v1

Quantitation of EPA and DHA in Fish Oil Dietary Supplements Sold in the United States

Joseph E. Hilton, William N. Setzer, Prabodh Satyal, Ambika Poudel, Sawyer Ashcroft, Rakesh Satyal

Subject: Analytical Chemistry, Chemistry And Materials Science Keywords: Fish oil; EPA; DHA; Label Claim; of ω -3 fatty acid

Online: 18 September 2024 (12:12:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1350.v1

Comparation of CALPUFF and CFD Modeling of Toxic Gas Dispersion in Mountainous Environments

Mei Li, ChoHo Lo, Dongou Yang, Yuanchen Li, Zhe Li

Subject: Atmospheric Science And Meteorology, Environmental And Earth Sciences Keywords: Mountainous Environment; High Sulphur Gas; CALPUFF; CFD; Atmospheric Dispersion Model

Online: 18 September 2024 (12:11:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1349.v1

Historical Analysis of Resilience in Spanish Desalination Companies: Period 1980-2024

Borja Montano

Subject: Food Chemistry, Chemistry And Materials Science Keywords: Desalination Industry; Renewable; Energy Integration

Online: 18 September 2024 (12:08:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1401.v1

Effects of Salt Concentration on a Magnetic Nanoparticle-Based Aggregation Assay with a Tunable Dynamic Range

Gabrielle Rose Moss, Christian Knopke, Solomon G Diamond

Subject: Bioengineering, Engineering Keywords: aggregation assay; magnetic particle spectroscopy; biosensor; tunable dynamic range

Online: 18 September 2024 (12:07:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1412.v1

Design and Development of a Self-Sufficient Riding Reaper Machine

Berisso Woyessa Bekele

Subject: Mechanical Engineering, Engineering Keywords: harvesting; reaper machine; mechanization; cost reduction; efficiency; product development; planning; testing

Online: 18 September 2024 (12:04:16 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202409.1348.v1

Optimized Nanocellulose-Based Magnetic Metal-Organic Frameworks for Antibiotic Adsorption: A Cutting-Edge Strategy in Environmental Remediation

Pham Vu Nhat Uyen, Dang Anh Tuan

Subject: Chemical Engineering, Chemistry And Materials Science Keywords: Nanocellulose; Metal-Organic Frameworks; Water Remediation; Antibiotic Adsorption; Environmental Sustainability

Online: 18 September 2024 (12:00:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1392.v1

Cannabis for Tic Control: A Systematic Review and Meta-Analysis of Its Efficacy in Tourette Syndrome Management

Dr. Govind Singh Mann, Dr. Ahmed Farid Gadelmawla, Dr. Ali Dway, Fathima Hayathi Fayaz, Dr. Eleni Asfaw Kebede, Nandha Kumar Varadharaj, Dr. Ayesha Akram, Aneeza Khan, Dr. Uchechi Blessing Azuwike, Dr. Bharath Kanumuri Sampangi, Dr. Oluwaseun Adeolu Ogundijo

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: Cannabinoids; Tourette Syndrome; Tics; Endocannabinoid system

Online: 18 September 2024 (12:00:51 CEST)

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Background:Tourette syndrome (TS) is a characterized by motor and vocal tics, often accompanied by obsessive-compulsive disorder (OCD) and attention-deficit/hyperactivity disorder (ADHD). Cannabis-based medicines (CBM) present a promising avenue for future therapeutic intervention owing to their interaction with the endocannabinoid system, potentially mitigating tics and associated symptoms. Unlike conventional treatments such as antipsychotics, CBM exhibits improved tolerability and reduced side effects. While the available evidence is still limited, ongoing research underscores the potential of CBM to enhance the quality of life for patients, establishing it as a pivotal area for future therapeutic advancements in TS. Aim: In our systematic review and meta-analysis, we aim to assess the effectiveness of cannabis-based medicine (CBM) in the treatment of Tourette Syndrome. Methods: We searched in electronic databases (PubMed, Google Scholar, Science Direct, Cochrane Collaboration Database of Randomized Trials) was performed to identify cohort studies and randomized controlled trials (RCTs) up to 18th June 2024. Data extraction focused on baseline characteristics of the included studies and efficacy outcomes, including scores on the Yale Global Tic Severity Scale (YGTSS) and Premonitory Urge for Tics Scale (PUTS). We conducted the meta-analysis using Review Manager version 5.4. software. We compared the measurements before and after CBM intake using mean difference (MD) and 95% confidence interval (CI). Result: In total, 1105 articles were identified for screening, with eight studies included in the systematic review and seven in the meta-analysis. These studies involved 306 adult patients with TS treated with cannabis. YGTSS revealed a significant reduction in total scores (MD = -13.29, 95% CI [-21.67 to -4.91], P = 0.002) and PUTS revealed a significant decrease in scores (MD = -4.09, 95% CI [-7.24 to -0.93], P = 0.01). Conclusion: The research emphasizes the potential of cannabis-based medication in alleviating tics and premonitory urges associated with Tourette syndrome. While the initial results are promising, they are based on limited-scale studies. It is imperative to conduct larger, placebo-controlled trials encompassing diverse demographic groups to substantiate the effectiveness, ensure safety, and optimize dosages for long-term therapeutic advantages.

Preprint COMMUNICATION | doi:10.20944/preprints202409.1379.v1

A Retrospective Report of Carprofen Administration as Post-Operative Analgesia Reveals Negative Effects of Recommended Doses

Zoë Jäckel, Ahmed Adžemović, Benedikt Kloos, Stefanie Hardung, Rita Sanchez-Brandelik, Philippe Coulon, Ilka Diester

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: analgesia; laboratory animals; animal welfare; multimodal drug administration; stereotactic surgery; refinement

Online: 18 September 2024 (11:59:13 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202409.1384.v1

Diagnostic Systematics in Transitional Cell Carcinoma of the Bladder: Case Report

José Cabrales Fuentes

Subject: Other, Public Health And Healthcare Keywords: Imaging; Bladder tumor; transitional cell carcinoma

Online: 18 September 2024 (11:58:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1383.v1

Comparative Study of the Development of EFs in Children: Transition from the First Cycle to the Second Cycle of Early Childhood Education

ESPERANZA BAUSELA BAUSELA

Subject: Education, Social Sciences Keywords: BRIEF-P™; Development; Early Childhood Education; EFs; Parents; Teachers

Online: 18 September 2024 (11:57:06 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202409.1377.v1

Tellurium-Doped Bioactive Glassinduces Ferroptosis in Osteosarcoma Cells Regardless of FSP1

Elzbieta Pańczyszyn, Mari Lallukka, Mara Gagliardi, Valentina Saverio, Romina Monzani, Marta Miola, Enrica Verné, Marco Corazzari

Subject: Life Sciences, Biology And Life Sciences Keywords: Ferroptosis; Tellurium; osteosarcoma; FSP1; biomaterials

Online: 18 September 2024 (11:55:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1366.v1

Cycle Threshold Values of SARS-CoV-2 RT-PCR During Outbreaks in Nursing Homes: A Retrospective Cohort Study.

Juan Carlos Gasco-Laborda, Maria Gil-Fortuño, Maria Dolores Tirado-Balaguer, Noemi Meseguer-Ferrer, Oihana Sabalza-Baztán, Óscar Pérez-Olaso, Iris Gómez-Alfaro, Sandrine Poujois-Gisbert, Noelia Hernández-Pérez, LLedó Lluch-Bacas, Viorica Rusen, Alberto Arnedo-Pena, Juan Bautista Bellido-Blasco

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: SARS-CoV-2; PCR; cycle threshold; infections; nursing homes; outbreaks; retrospective cohort

Online: 18 September 2024 (11:47:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1399.v1

Exploring the Plastic Surgery Related Experiences, Needs, Confidence and Knowledge Gaps of Foundation Year Doctors

Natalia Gili

Subject: Surgery, Medicine And Pharmacology Keywords: Plastic surgery; junior doctors; experiences; needs; knowledge gaps

Online: 18 September 2024 (11:45:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1409.v1

Beyond Genetics: The Role of Familial Comorbidities in Shaping Migraine Phenotypes

Tugce Ozdemir Gultekin, Sevim Eyupoglu, Ezgi Uluduz, Derya Uluduz, Aynur Ozge

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: migraine; chronic migraine; episodic migraine; familial transmission; comorbidities; hypercholesterolemia; headache clinics

Online: 18 September 2024 (11:44:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1352.v1

Evaluating the Efficacy of Oral Chloral Hydrate and Determinants of Median Induction Time for Pediatric MRI Procedural Sedation: A Time-to-Event Analysis Perspective

Sara Amer Alomar, Ahmed Nawfal Alshammari, Fahad Alnajim, Maan Abdullah Albesair, Amr Esmail, Abdullah BinHasan, Fay Fahad Aldenaini, Mohammed Shahab Uddin

Subject: Pediatrics, Perinatology And Child Health, Medicine And Pharmacology Keywords: Chloral Hydrate; Magnetic Resonance Imaging (MRI); Pediatric Sedation; Procedural Sedation; Drug Efficacy; Pediatrics

Online: 18 September 2024 (11:39:31 CEST)

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Background: Magnetic Resonance Imaging (MRI) is essential in pediatric diagnostics; however, the need for effective sedation due to children’s inability to remain still presents a challenge. Oral Chloral Hydrate (OCH) is commonly used for its efficacy and safety, but there is a lack of detailed exploration of the median induction time, the period from administration to effective sedation. This study aimed to evaluate the efficacy of OCH and identify the determinants of the median induction time for pediatric MRI procedural sedation.Methods: This retrospective study evaluated oral chloral hydrate (50-100 mg/kg) for pediatric MRI sedation using records from the Imam Abdulrahman Bin Faisal Hospital (2018-2022). Pediatric patients (1–8 years) were assessed for sedation efficacy, with exclusion criteria for allergies or incomplete data. Time-to-event analysis (Kaplan–Meier and Cox regression) was used to identify factors influencing sedation induction time. The data included age, weight, dose, and outcomes. The analysis highlighted the key predictors of sedation success and optimized procedural sedation protocols.Results: The study included 183 pediatric patients with a median age of 30 months and a median chloral hydrate dose of 66 mg. Sedation success was 85.79%, with younger age and shorter induction times being significantly associated with success (p<0.001). Kaplan-Meier analysis showed no significant difference in induction times between the neurological and non-neurological groups (p=0.64). Cox regression identified longer MRI duration and multiple doses as significant factors influencing the timing of sedation (p=0.050, p=0.008). Bootstrap analysis confirmed a robust median induction time of 30 minutes.Conclusions: Oral chloral hydrate achieved 85.79% success in pediatric MRI sedation, with younger and lighter patients having better outcomes. The median sleep induction time was 30 minutes, and extending sedation to 60 minutes further improved the success rate.

Preprint REVIEW | doi:10.20944/preprints202409.1395.v1

The Long-Term Effects of Using Placebo in Asthma Treatments

Napatcha Kaewkumnerd, Pirada Ramingwong

Subject: Pulmonary And Respiratory Medicine, Medicine And Pharmacology Keywords: placebo; asthma; long-term effects; hyperreactivity; bronchial inflammation ;

Online: 18 September 2024 (11:39:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1361.v1

Construction of Lyapunov Certificates for Systems on Torus Using Trigonometric Polynomials

Mahmut Kudeyt, Swapnil Tripathi, Alkım Gökçen, Savaş Şahin, Ozkan Karabacak

Subject: Control And Systems Engineering, Engineering Keywords: almost global synchronization; trigonometric polynomials; stability certificates

Online: 18 September 2024 (11:38:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1351.v1

Functional Morphology of the Mouthparts of Ladybeetle Vibidia duodecimguttata (Coleoptera: Coccinellidae), with Emphasis on Their Sensilla

Long Chen, Yaping Shi, Ke Wang, Yuanxing Sun, Yanan Hao

Subject: Insect Science, Biology And Life Sciences Keywords: mouthparts; sensilla; Vibidia duodecimguttata; scanning electron microscopy

Online: 18 September 2024 (11:37:59 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1354.v1

The Therapeutic Target of SGLT2 Inhibitors and GLP-1 Agonists Is Superoxide Induced Diuretic Resistance

Wayne Kaesemeyer MD

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: superoxide; SGLT2 inhibitors; GLP-1 agonists; cardiorenal syndrome; diuretic resistance; heart failure

Online: 18 September 2024 (11:37:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1363.v1

Anticipated Immigration Rate Changes Necessary to Maintain Canadian Population with Proposed Expansion of Medical Assistance in Dying for Mental Health Disorders

Uzair Jamil, Joshua M. Pearce

Subject: Health Policy And Services, Public Health And Healthcare Keywords: Canada; euthanasia; immigration; medical assistance in dying; MAiD; population

Online: 18 September 2024 (11:37:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1360.v1

Urban Forestry in Sub-Saharan Africa: Challenges, Contributions, and Future Directions for Combating Climate Change and Restoring Forest Landscape

Sawaba ALE, Kossi ADJONOU, Kossi Novigno SEGLA, Kossi KOMI, Jean-Bosco Benewinde ZOUNGRANA, Coffi AHOLOU, Kouami Kokou

Subject: Forestry, Biology And Life Sciences Keywords: Urban forestry; green space; urban heat islands; forest landscape restoration; city planning

Online: 18 September 2024 (11:37:46 CEST)

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Since the 1960s, the countries of sub-Saharan Africa have been affected by an urban crisis due to the demographic explosion in cities and the resulting land pressures. These have resulted in the proliferation of spontaneous housing areas which question the future of urban vegetation and its degree of inclusion in city planning. To analyze the state of knowledge on the research already carried out on the development of urban landscape, particularly in sub-Saharan Africa, a literature review on urban forestry covering the period 1998-2022 was carried out in order to better orient future research works for a greater consideration to urban forestry and their contributions in combating the adverse effects of climate change. Out of a set of 110 scientific papers selected, 50 were considered relevant because of their direct link with urban forestry. From the analysis of this papers, a classification of the articles according to 05 themes was carried out. These are: management of green spaces in urban areas, functions of trees in an urban environment, development of urban forestry, characterization of urban tree flora and financing of urban forestry. Thus, “function of trees in an urban environment and the characterization of urban tree flora” are the most addressed respectively at 42% and 28%. “Financing urban forestry” is practically not addressed (2%). The analysis of the 50 selected articles reveals a significant geographic concentration of urban forestry research. Countries like South Africa, Kenya, and Ghana are more represented in the literature, while vast regions in Central and Western Africa (e.g., Democratic Republic of Congo, Chad, and Niger) have minimal or no documented research on urban forestry. Future research should address these underrepresented themes, as they are crucial for the long-term sustainability of urban forestry projects. Particularly, research on financing mechanisms is essential to unlock sustainable funding sources for urban forestry, a critical barrier to its expansion.

Preprint ARTICLE | doi:10.20944/preprints202409.1381.v1

Designing Personalized Learning Paths for Foreign Language Acquisition Using Big Data: Theoretical and Empirical Analysis

Yina Xia, Seong-Yoon Shin, Kwang-Seong Shin

Subject: Computer Science, Computer Science And Mathematics Keywords: Personalized Learning; Big Data Analytics; Language Acquisition; Educational Technology; Learner Engagement

Online: 18 September 2024 (11:37:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1400.v1

An Innovative Way of Studying Plane Curves Based on Educational Robotics at University Level

Szilvia Szilágyi, Attila Körei, And Ingrida Vaičiulytė

Subject: Robotics, Computer Science And Mathematics Keywords: educational robotics; STEM-based education; LEGO robotics; central trochoids; drawing devices; higher education

Online: 18 September 2024 (11:34:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1356.v1

Single-stage Image-guided Percutaneous Ablation with Thoracoscopic Resection for Multiple Pulmonary Lesions in a Hybrid Operating Room: A Retrospective Study

Ling-Kai Chang, Po-Keng Su, Pak-Si Chan, Shwetambara Malwade, Wen-Yuan Chung, Shun-Mao Yang

Subject: Surgery, Medicine And Pharmacology Keywords: Lung cancer; hybrid operating room; surgical resection; ablation; multiple lung lesions

Online: 18 September 2024 (11:29:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1391.v1

FGFR2 in the Development and Progression of Cutaneous Squamous Cell Cancer

Ethan M. Kallenberger, Alok Khandelwal, Priyatosh Nath, Shaun A. Nguyen, John DiGiovanni, Cherie-Ann O. Nathan

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: Cutaneous Squamous Cell Carcinoma; Fibroblast Growth Factor Receptor 2; Treatment Resistance; Epithelial Mesenchymal Transition; Metastasis; Immunosuppression

Online: 18 September 2024 (11:16:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1397.v1

Extended-Spectrum Beta Lactamase-Producing E. Coli in Freshwater Lakes Along an Anthropogenic Impact Gradient

Aaron Bivins, Abhishek Srivastava, Anant Katara, Katherine Weise, Akanksha Singh Kachhawaha

Subject: Public, Environmental And Occupational Health, Public Health And Healthcare Keywords: antibiotic resistance, E. coli, extended-spectrum beta-lactamase, lakes, antimicrobial resistance, Tricycle Protocol, environmental surveillance, ESBL-Ec

Online: 18 September 2024 (11:16:02 CEST)

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The World Health Organization recently proposed the Tricycle Protocol for harmonized surveillance of extended-spectrum beta lactamase-producing E. coli (ESBL-Ec) as a proxy for AMR among humans, animals, and the environment. We implemented the Tricycle Protocol with ceftriaxone (CRO) to screen for ESBL-Ec using membrane filtration (TBX-CRO) and Colilert Quanti-Tray (CQT-CRO) workflows in parallel applied to water samples collected from four lakes. ESBL-Ec and E. coli abundance and prevalence, and ESBL-Ec to E. coli ratios were significantly higher in the two highly impacted lakes (receiving sewage treatment plant effluent, open defecation site adjacent to informal settlements) compared to less impacted lakes (wildlife sanctuary, recreational site). The cumulative burden of antibiotic compounds was also higher in the highly impacted lakes. Even in the “pristine” lake in a bird sanctuary, ESBL-Ec and an antibiotic compound were present. Overall, the CQT-CRO format yielded reasonable qualitative (K = 0.603) and quantitative agreement (intra-class correlation coefficient = 0.849) and linearity (r² = 0.785) with the TBX-CRO format adapted from the Tricycle Protocol. However, CQT-CRO doubled the prevalence of ESBL-Ec in settings with decreased E. coli abundance. Consistent with observations for other third-generation cephalosporins, CRO performed poorly for screening the ESBL phenotype. Further, confirmed ESBL-Ec isolates were not associated with an increased number of resistance phenotypes compared with non-ESBL isolates. Instead, the number of resistance phenotypes was associated with the lake from which the sample was collected. In high-burden settings, AMR surveillance efficiency could be increased by directly testing generic E. coli isolates for ESBL phenotype and antibiotic susceptibility. Our experience also suggests that sequencing ESBL-Ec will likely be required to determine epidemiologically appropriate risk mitigation strategies where ESBL-Ec are prevalent. Resource limitations could jeopardize the relevance of the Tricycle Protocol for changing the trajectory of AMR in high-burden low-resource settings globally.

Preprint ARTICLE | doi:10.20944/preprints202310.1872.v12

Alena Tensor and Its Possible Applications in Unification Theories

Piotr Ogonowski, Piotr Skindzier

Subject: Theoretical Physics, Physical Sciences Keywords: unification; electrodynamics; general relativity; dark energy; dark matter; quantum field theory; quantum mechanics; continuum mechanics

Online: 18 September 2024 (11:13:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1387.v1

Study on the Design of a New Three-Dimensional Seismic Isolation Bearing Based on Improved Genetic Algorithm for Bridge Engineering

Ying Sheng, Zhenchao Yang, Yu Meng, Bin Jia

Subject: Civil Engineering, Engineering Keywords: three-dimensional seismic isolation bearing; bridge engineering; sensitivity of the design parameters; improved genetic algorithm; good seismic isolation effect

Online: 18 September 2024 (11:12:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1294.v1

Huan Xiao

Subject: Algebra And Number Theory, Computer Science And Mathematics Keywords: Riemann zeta function; Riemann hypothesis

Online: 18 September 2024 (11:12:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1378.v1

Ecological-Health Hazards and Multivariate Assessment of Contamination Sources of Potentially Toxic Elements from Al-Lith Coastal Sediments, Saudi Arabia

Talal Alharbi, Abdelbaset S. El-Sorogy, Khaled Al-Katany, Suhail Alhaji

Subject: Environmental Science, Environmental And Earth Sciences Keywords: potentially toxic elements; hazard Index; lead; arsenic; chromium; lifetime cancer risk

Online: 18 September 2024 (11:11:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1394.v1

A Systematic Review of the Current State of Numerical Groundwater Modeling in Latin American Countries: Challenges and Future Research

Baltazar Leo Lozano Hernández, Ana Elizabeth Marín Celestino, Diego Armando Martínez Cruz, José Alfredo Ramos Leal, Eliseo Hernández Pérez, Joel García Pazos, Oscar Guadalupe Almanza Tovar

Subject: Water Science And Technology, Environmental And Earth Sciences Keywords: FEFLOW; Flow simulation; Forecasting; Groundwater; Latin America; MODFLOW; Numerical modeling

Online: 18 September 2024 (10:55:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1307.v2

Exploring the Frontier of Semiconductor Technologies: Innovations, Sustainability and Future Opportunities—A Review

Luckman Yeboah, Peter Agyemang, Ayinawu Abdul Malik, Prince Acheampong, Joseph Morgan, Rose Addo, Boris Williams Henyo

Subject: Metallurgy And Metallurgical Engineering, Engineering Keywords: semiconductor; microchip; hardware; sustainability; transistors; manufacturing

Online: 18 September 2024 (10:42:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1302.v1

Motherhood in the Making: Key Determinants of Parenthood Motivation in Young Adult Women

Dario Vučenović, Matea Petrović, Katarina Jelić

Subject: Psychology, Social Sciences Keywords: childbearing motivation, attachment, emotional intelligence

Online: 18 September 2024 (10:29:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1347.v1

Evaluating Stacked Dielectric Elastomer Actuators as Soft Motor Units for Forming Artificial Muscles in Biomimetic Rehabilitation Robots

Vahid Mohammadi, Sahel Mohammadi Ghalehney, Mohammad Tajdani, Samuel C.K. Lee, Ahad Behboodi

Subject: Bioengineering, Engineering Keywords: Actuators; Muscles; Rehabilitation robotics; Soft robotics; SDEA; Force.

Online: 18 September 2024 (10:26:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1390.v1

Droplet Digital Pcr Enhances Sensitivity and Accuracy in Canine Distemper Virus Detection

Victoria Iribarnegaray, Guillermo Godiño, Camila Larrañaga, Kanji Yamasaki, José Manuel Verdes, Rodrigo Puentes

Subject: Veterinary Medicine, Medicine And Pharmacology Keywords: droplet Digital PCR; canine distemper virus; molecular diagnosis

Online: 18 September 2024 (10:24:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1389.v1

Nanostructured Polymer Dispersed Liquid Crystals Using a Ferroelectric Smectic a Liquid Crystal

Masaki Yamaguchi, Hiroyuki Matsukizono, Yasushi Okumura, Hirotsugu Kikuchi

Subject: Applied Chemistry, Chemistry And Materials Science Keywords: Polymer dispersed liquid crystals; Memory effect; Birefringence; Molecular orientation

Online: 18 September 2024 (10:21:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1393.v1

Bioprospecting of Metsnikowia pulcherrima Strains, Isolated from the Vineyard Ecosystem, as Novel Starter Cultures for Craft Beer Production

Julian Karaulli, Nertil Xhaferaj, Francesca Coppola, Bruno Testa, Francesco Letizia, Onejda Kyçyk, Renata Kongoli, Mamica Ruci, Fatbardha Lamçe, Kapllan Sulaj, Massimo Iorizzo

Subject: Food Science And Technology, Biology And Life Sciences Keywords: craft beer; Metschnikowia pulcherrima; Saccharomyces cerevisiae; sequential inoculation

Online: 18 September 2024 (10:06:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1380.v1

Nonlinear Responses of COVID-19 Incidence Rates to Temperature, Relative Humidity, Ultraviolet Radiation, and Diurnal Temperature Range

Hao Zhang, Jian Wang, Zhong Liang

Subject: Environmental Science, Environmental And Earth Sciences Keywords: COVID-19; meteorological factors; distributed lag nonlinear model (DLNM); global; Nonlinear Response

Online: 18 September 2024 (09:34:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1346.v1

Leveraging Bioactive Proteins and Peptides from Lumbricus Earthworms: Targeting SOCS2 E3 Ligase for Cardiovascular Therapy through Molecular Dynamics Simulations

Nasser Alotaiq, Doni Dermawan

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: cardiovascular disease; earthworm; lumbrokinase; molecular dynamics simulation; SOCS2; protein-protein interactions

Online: 18 September 2024 (09:16:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1342.v1

Heat Stress in Japanese Quails (Coturnix coturnix japonica): Benefits of Phytase Supplementation

Apolônio Gomes Ribeiro, Raiane dos Santos Silva, Dayane Albuquerque da Silva, Júlio Cézar dos Santos Nascimento, Lilian Francisco Arantes de Souza, Edijanio Galdino da Silva, José Evangelista Santos Ribeiro, Danila Barreiro Campos, Clara Virgínia Batista de Vasconcelos Alves, Edilson Paes Saraiva, Fernando Guilherme Perazzo Costa, Ricardo Romão Guerra

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: Antinutritional factors; Calcium absorption; Calbindin-D28K; Exogenous enzymes; TRPV6.

Online: 18 September 2024 (08:53:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1344.v1

Implementation and Evaluation of an evidence-based group antenatal care program in two Nigerian states: Design and baseline data collection

W. Douglas Evans, Chinwe L. Ochu, Jeffery B. Bingenheimer, Samson Babatunde Adebayo, Fasiku Adekunle David, Sani Ali Gar, Masduk Abdulkarim

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Group antenatal care; perinatal care; family planning; maternal and child health; program evaluation; implementation science; low and middle income countries; Nigeria

Online: 18 September 2024 (08:52:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1340.v1

Enhanced Chemical Stability of Tetramethylammonium Head Groups via Deep Eutectic Solvent: A Computational Study

Mirat Karibayev, Bauyrzhan Myrzakhmetov, Yanwei Wang, Almagul Mentbayeva

Subject: Physical Chemistry, Chemistry And Materials Science Keywords: Tetramethylammonium Head Groups; Deep Eutectic Solvent; Anion Exchange Membranes; Chemical Stability; Density Functional Theory; Molecular Dynamics; Ylide Formation; Nucleophilic Substitution

Online: 18 September 2024 (08:24:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1375.v1

Enhancing Upper Limb Stroke Rehabilitation with Electromyography-Monitored Virtual Reality-Based Games

Zunaidi Ibrahim, Basri Noor Cahyadi, Azlan Aziz, Ahmad Shamil

Subject: Control And Systems Engineering, Engineering Keywords: Upper limb rehabilitation; VR Games Rehabilitation; Electromyography (EMG); Deltoid Muscle Recovery; Kinect Xbox; Control Rehabilitation

Online: 18 September 2024 (08:21:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1372.v1

Self-Esteem, Student Engagement, and Academic Performance in Universitas Terbuka, Indonesia

Udan Kusmawan

Subject: Education, Social Sciences Keywords: Self-esteem; Student engagement; Academic performance; Distance education; Family systems

Online: 18 September 2024 (07:24:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1353.v1

Machine Learning Discoveries of Interleukin-X Synergy in ETC-1922159 Treated Colorectal Cancer Cells

Shriprakash Sinha

Subject: Mathematical And Computational Biology, Computer Science And Mathematics Keywords: ; Interleukin(IL),PorcupineinhibitorETC-1922159,Sensitivityanalysis, Colorectal cancer. ;

Online: 18 September 2024 (07:13:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1341.v1

A Combined Protection System for Wind Generators

Vladimir Kaverin, Gulim Nurmagambetova, Gennadiy Em, Sultanbek Issenov, Galina Tatkeyeva, Aliya Maussymbayeva

Subject: Other, Social Sciences Keywords: protection system; wind generator; emergency situations; icing; lightning; vibration; temperature increase

Online: 18 September 2024 (07:12:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1231.v1

Simplified Modelling Techniques for Dynamic Wireless Power Transfer

Krzysztof Jakubiak, Jun Liang, Liana Cipcigan, Chuanyue Li, Jinzhe Wu

Subject: Electrical And Electronic Engineering, Engineering Keywords: dynamic wireless power transfer; wireless power transfer; electric vehicles; dynamic wireless charging; mutual inductance; system modeling; high-frequency simulation; wireless charging; system modeling

Online: 18 September 2024 (05:35:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1232.v1

Predictive Model of the Effects of Skin Phototype and Body Mass Index on Photobiomodulation Therapy for Orofacial Disorders

Alice Cassemiro, Lara Jansiski Motta, Paulo Fiadeiro, Elsa Fonseca

Subject: Optics And Photonics, Physical Sciences Keywords: photobiomodulation; Monte Carlo; laser dosimetry; machine learning

Online: 18 September 2024 (05:31:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1233.v1

Immobilization of Phospholipase D on Magnetic Graphene Oxide for Efficient Phosphatidylserine Production

Huiyi Shang, Bishan Guo, Juntan Wang, Huijuan Li, Haihua Zhu

Subject: Biology And Biotechnology, Biology And Life Sciences Keywords: phospholipase D; immobilization; phosphatidylserine

Online: 18 September 2024 (05:26:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1304.v1

Whole Exome Sequencing of Meningioma in Sudanese Patients

Sawsan Aldeaf, Alsadig Gassoum, Nihad Elsadig, Mohamed Arbab, Muntaser Ebrahim

Subject: Medicine And Pharmacology, Other Keywords: WES; AKT1; CD44; meningioma; candidate genes; NCNS

Online: 18 September 2024 (05:24:59 CEST)

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Introduction Meningioma is the second most common primary intracranial tumor of the central nervous system. in Sudan, meningioma is the most common primary brain tumor, among Sudanese patients, Surgical total excision of meningioma offers a better survival, however, Chemotherapy has largely been unsuccessful for meningioma treatment, and therefore, refractory and recurrence meningioma treated with palliative surgery and radiotherapy. Monosomy of chromosome 22 is the utmost common genetic alteration among meningioma and many genes were investigated and described in the development of this tumor of which , NF2 hSNF5/INI1gene, P53. In addition to this, Molecular signal pathways in meningioma, and that contribute to the survival, proliferation, self-renewal, and differentiation properties of normal stem cells which are abnormally activated and nominated as cancerous stem cell (CSCs). Objectives 1/ To identify the possible pathway of candidate genes in both setting and whole genes hypothesis free approach 2/ To assess the presence of mutations in candidate genes among histological subtypes of meningioma in Sudan. Material and methods This is a prospective cross-sectional study done at the National Center of Neurological Sciences (NCNS) Khartoum, from 2018 to 2021. The study included all cerebral tumors that were radio- logically diagnosed preoperatively as meningioma. Ethical approval was taken from Institute of Endemic disease, Khartoum University, and written consent was obtained Three DNA extracts were randomly selected from 20 meningioma tissue samples and processed for WES. All genes harboring exonic and splice site variations stratified into SNVs and INDELs sets were prepared. The 1000G online database was used to explore novel mutations per 3 samples. SIFT and PolyPhen-2 programs were used to predict possible impact of amino acids substitution. To address meticulous genes interaction and particular centrality, all shared genes within the class INDEL and SNVs were used as input on Network Analysis to predict protein- protein interaction and functional gene ontology. Finally, shared mutations within genes of centrality were detected via Sanger sequencing and mutations were correlated between histological sub-types and recurrenceThree non meningioma brain tumor used as control. Results WES analysis revealed high number for mutational signature within 2 classes (INDEL and SNVs) per 3 samples, the findings of 1000 genome online database showed number of novel mutations; 5618 in fibrous , 6032 in meningothelial while in recurrent fibrous sample 5930. Network analysis of shared genes per each class (INDEL, SNVs), showed UBC is the most protein of remarkable degree centrality over thousand of genes. Whereas, all shared genes per 3 samples within the 2 classes (INDEL and SNVs) revealed Akt1 with the highest degree of centrality and betweenness. Akt1 rs17846829was detected in 20% of the samples, while CD44 stemness gene revealed mutation A>G (rs9666607) in all meningioma samples (100%), this mutation was associated with 60% of the recurrence. Conclusions Nevertheless, the present study, highlight how such complex molecular processes might contribute to tumorogenesis, in attempt to shed light over thousands of genes and multifaceted network analysis rather than a solitary gene which is challenging question.

Preprint ARTICLE | doi:10.20944/preprints202409.1228.v1

A Decentralized Digital Watermarking Framework for Secure and Auditable Video Data in Smart Vehicular Networks

Xinyun Liu, Ronghua Xu, Yu Chen

Subject: Electrical And Electronic Engineering, Engineering Keywords: Intelligent Transportation System (ITS); Internet of Vehicles (IoV); Digital Watermarking; Deep Learning; Blockchain; Security

Online: 18 September 2024 (05:22:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1357.v1

Antibiotic Resistance of Helicobacter pylori: Data from Central Asia

Seysenbekova Aizhan, Lavrinenko Alyona, Laryushina Yelena, Ayatbek Otemis, Volnovaya Olga, Maxim Solomadin, Yekaterina Yuchmevich, Antonella Chesca

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Helicobacter pylori; antibiotic resistance; Central Asia

Online: 18 September 2024 (05:22:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1244.v1

The Influence of In-Plane Constraints on Fatigue Crack Growth Rate

Jaroslaw Galkiewicz, Urszula Janus-Galkiewicz, Sebastian Lipiec

Subject: Mechanical Engineering, Engineering Keywords: fatigue crack growth; Paris’ law; in-plane constraints; brittle fracture; Williams’ solution

Online: 18 September 2024 (05:17:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1240.v1

Platelet Responses after Tapering and Discontinuation of Fostamatinib in Patients with Immune Thrombocytopenia: A Continuation of the Fostasur Study

Maria-Eva Mingot-Castellano, Gloria Garcia-Donas, Rosa Maria Campos-Alvarez, Maria Carmen Fernández-Sánchez de Mora, Josefa Luis-Navarro, Juan Francisco Domínguez-Rodriguez, Maria del Mar Nieto-Hernandez, Irene Sánchez-Bazán, Maria Yera-Cobo, Rocio Cardesa-Cabrera, Francisco Jose Jímenez-Gonzalo, Isabel Caparrós-Miranda, Laura Entrena-Ureña, Sergio Jurado-Herrera, Dolores Fernández Jimenez, Dana Díaz-Canales, Gloria Moreno-Carrasco, Cristina Calderón-Cabrera, Ramiro Jose Nuñez-Velazquez, Begoña Pedrote-Amador, Reyes Jiménez-Bárcenas

Subject: Medicine And Pharmacology, Hematology Keywords: tapering; sustained response; ITP; fostamatinib; thrombopoietin analogs; Syk inhibitor; Syk; remission; purpura; thrombocytopenic; idiopathic; diarrhea; hemorrhage; thrombocytopenia

Online: 18 September 2024 (05:14:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1237.v1

Long-Term Effects of Nitrogen Sources on Yields, Nitrogen Use Efficiencies, and Soil

Jorge A. Delgado, Robert E D'Adamo, Catherine E Stewart, Bradley Floyd, Steve J Del Grosso, Daniel K Manter, Ardell D Halvorson, Amber Brandt

Subject: Soil Science, Environmental And Earth Sciences Keywords: EEF; manure nitrogen; nitrogen use efficiencies; phosphorus; soil and water conservation; sustainability

Online: 18 September 2024 (05:10:22 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202409.1236.v1

UE4 Redundant Asset Detection Method Based on Pointer Analysis

Tingzhen Liu

Subject: Software, Computer Science And Mathematics Keywords: program analysis; static analysis; pointer analysis; data flow analysis; flow sensitivity; game develop

Online: 18 September 2024 (05:05:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1291.v1

Qualitative Insights into Cultural Heritage Protection in Serbia: Evaluating Legal and Institutional Gaps

Vladimir M. Cvetković, Stefan Gole, Renate Renner, Tin Lukić

Subject: Safety Research, Social Sciences Keywords: disasters; hazards; cultural heritage; protecting; qualitative research; interview; Serbia

Online: 18 September 2024 (04:57:53 CEST)

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This research is dedicated to a comprehensive examination of the strengths and weaknesses inherent in the legal and institutional measures designed to protect cultural heritage in the Republic of Serbia from the adverse effects of natural disasters, including earthquakes, landslides, rockfalls, floods, torrents, storms, hail, and forest fires. The study aims to identify the primary challenges and shortcomings within the existing legal and institutional framework, while also pinpointing and analyzing best practices and potential improvements for the protection system. This research posits a preliminary hypothesis suggesting that challenges may exist within the legal and institutional framework for the protection of cultural heritage in the Republic of Serbia, potentially limiting effective response and recovery following natural disasters. This hypothesis will be further developed and adapted based on the analysis of available data. Data collection for this research was conducted through semi-structured interviews with experts and an in-depth analysis of existing documentation. By conducting interviews with experts in the field, the research seeks to gather critical data and insights that will enhance the understanding of these issues and contribute to formulating viable solutions. The analysis and processing of data were carried out using ATLAS.ti software, which facilitated a comprehensive and systematic examination of the collected qualitative information. Furthermore, an assessment of the current capacity of institutions to respond rapidly and effectively to natural disasters that pose a threat to cultural heritage is a key component of the study. The ultimate goal is to develop recommendations that will fortify the legal and institutional framework, thereby bolstering the resilience of cultural heritage sites in Serbia against future natural disasters. The results of the research, highlight significant deficiencies in the legal framework, inadequate institutional capacities and resources, as well as a lack of proper training for crisis response. The need for improved inter-institutional cooperation and the development of technical-logistical resources is emphasized. This paper represents a significant contribution to the understanding and enhancement of the cultural heritage protection system, providing a foundation for further research and strategy development in this area.

Preprint ARTICLE | doi:10.20944/preprints202409.1355.v1

Comparison of Different Quantitative Precipitation Estimation Methods Based on a Severe Rainfall Event in Tuscany, Italy, November 2023

Alessio Biondi, Luca Facheris, Fabrizio Argenti, Fabrizio Cuccoli

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: Weather radar; rain gauge; quantitative precipitation estimation (QPE); rainfall; data fusion; merging methods

Online: 18 September 2024 (04:55:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1293.v1

Microbiological Diagnosis – an Important Tool for Prevention and Management of Peri-Implant Infective Diseases

Adrian Țandără, Cristian Funieru, Oana Slușanschi, Cristina Preoteasa

Subject: Dentistry And Oral Surgery, Medicine And Pharmacology Keywords: peri-implant infective diseases; microbiota; antibiogram

Online: 18 September 2024 (04:51:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1287.v1

A Game-Theoretic Model of Global AI Development Race: Dynamics of Domination and Technological Catch-up

Richard Murdoch Montgomery

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: Artificial Intelligence; Technological Race; Game Theory; Monte Carlo Simulation; Technological Domination; Catch-up Dynamics; National Development Strategies; Global Competition; Innovation Policy; Technological Leapfrogging

Online: 18 September 2024 (04:48:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1309.v1

Emerging Trends in Flavonoid Research: Advances in Understanding and Applications

Shashank Tiwari, Shreya Talreja

Subject: Other, Public Health And Healthcare Keywords: Flavonoids; phytochemicals; antioxidants; anti-inflammatory; anticancer; cardiovascular health; neuroprotection; antimicrobial; dietary sources; metabolism; bioavailability; therapeutic potential

Online: 18 September 2024 (04:44:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1285.v1

Wearable Light Loggers in Field Conditions: Corneal Light Characteristics, User Compliance and Acceptance

Oliver Stefani, Reto Marek, Jürg Schwarz, Sina Plate, Johannes Zauner, Björn Schrader

Subject: Other, Public Health And Healthcare Keywords: light dosimetry; usability; daytime light exposure; evening light exposure; wearable light loggers; wearable technology; circadian lighting; corneal light exposure

Online: 18 September 2024 (04:42:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1326.v1

Machine Learning-Based Mortality Risk Stratification in Synovial Sarcoma Patients: A Retrospective Study

Saba Naderian Jahromi, Sadaf Raoufi, Mohammad Rahimi, Danial Bazmandeh, Asal Salehi, Kianmehr Saleh, Aidin Tarokhian

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: Machine Learning; Synovial Sarcoma; Artificial Intelligence; Mortality

Online: 18 September 2024 (03:59:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202409.1336.v1

The Evolving Global Epidemiology of Human Melioidosis

Francesca F Norman, Barbra M Blair, Sandra Chamorro-Tojeiro, Marta Gonzalez-Sanz, Lin H Chen

Subject: Epidemiology And Infectious Diseases, Medicine And Pharmacology Keywords: Burkholderia pseudomallei; travel; imported; climate change; Hemophagocytic lymphohistiocytosis; nosocomial transmission

Online: 18 September 2024 (03:51:56 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202409.1320.v1

Evaluating the Impact of Fed and Domestic Monetary Policies on Long-Term Government Bond Yields

Srinivas Raju Gottimukkala

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Federal Open Market Committee; Financial; Ordinary Least Squared; US Federal Reserve

Online: 18 September 2024 (03:46:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1325.v1

Exploring the Impact of Crypto-Ransomware on Critical Industries: Case Studies and Solutions

Austin Yee Meng Jun, Bryan Alexander Jinu, Lay Kah Seng, Muhamad Haris Firdaus Bin Zainol Maharaiq, Wadthanak Khongsuwan, Bryan Thong Kai Junn, Aidan Au Wen Hao, Siva Raja Sindiramutty

Subject: Computer Science, Computer Science And Mathematics Keywords: Crypto Ransomware; Cybersecurity; Ransomware Attack; Cryptocurrency; Data Encryption

Online: 18 September 2024 (03:22:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0172.v13

Dirac Fermion of a Monopole Pair (MP) Model

Samuel Yuguru

Subject: Theoretical Physics, Physical Sciences Keywords: Dirac fermion; Quantum mechanics; Quantum field theory; Dirac belt-trick; 4D space-time

Online: 18 September 2024 (03:22:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1322.v1

Perception of the Barriers to the Implementation of a Successful Climate Change Policy in Bulgaria

Kliment Minev Naydenov, Antonina Traykova Atanasova

Subject: Environmental And Earth Sciences, Other Keywords: climate change; policy; effectiveness; regulations; perceptions; barriers; stakeholders

Online: 18 September 2024 (03:22:25 CEST)

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