Search | Preprints.org

Preprint ARTICLE | doi:10.20944/preprints202308.0610.v1

The Effect of High-Intensity Interval Exercise on Short-Term Glycaemic Control, Serum Level of Key Mediator in Hypoxia and Pro-Inflammatory Cytokines in Patients with Type 1 Diabetes

Barbara Hall, Aleksandra Żebrowska, Marcin Sikora, Szymon Siatkowski, Anna Robins

Subject: Biology And Life Sciences, Endocrinology And Metabolism Keywords: type 1 diabetes; high-intensity interval exercise; glycaemic control; hypoxia; inflammation

Online: 8 August 2023 (10:18:30 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202304.1197.v1

Coupled miR-155 Deficiency and Hypoxia Lead to the Upregulation of SLC2A3 (GLUT3) and VEGFA in the Leukemic B-cells

Elena Golovina, Tomas Heizer, Lenka Daumova, Martin Bajecny, Karina Savvulidi Vargova

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: B-cells, hypoxia, miRNA, CRISPR/Cas9, leukemia, gene expression, cell viability

Online: 29 April 2023 (03:34:08 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202211.0170.v1

The Wound Microenvironment and Recent Therapeutic Advances to Treat Wounds

Kevin Dzobo, Fatemeh Tavakoli Foroushani

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: wound healing; inflammation; microenvironment; stem cells; extracellular matrix; hypoxia; growth factors

Online: 9 November 2022 (03:41:12 CET)

Show abstract| Download PDF| Share

Working Paper ARTICLE

Inhalational Anesthetics Inhibit Neuroglioma Cell Proliferation and Migration via miR-138, -210 and -335

Masashi Ishikawa, Masae Iwasaki, Hailin Zhao, Junichi Saito, Cong Hu, Qizhe Sun, Atsuhiro Sakamoto, Daqing Ma

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: microRNA; sevoflurane; desflurane; hypoxia inducible factor-1α; matrix metalloproteinase 9; glioma

Online: 23 March 2021 (09:14:01 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202007.0527.v1

Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells

Andrew Sulaiman, Sarah McGarry, Jason Chambers, Emil Al-Kadi, Alexandra Phan, Li Li, Karan Mediratta, Jim Dimitroulakos, Christina Addison, Xuguang Li, Lisheng Wang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Triple Negative Breast Cancer; Cancer Stem Cell; Hypoxia; EGFR; Cisplatin; PDX

Online: 22 July 2020 (11:32:30 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints201805.0106.v1

The Diagnostic Value of HIF-2 Alpha to Determine The Development and Efficacy of Treatment for Contrast Induced Nephropathy: An Experimental Study

Ismail Altintop, Mehmet Tatli, Cigdem Karakukcu, Zeynep Soyer Sarica, Arzu Hanım Yay, Esra Balcioglu, Ahmet Ozturk

Subject: Medicine And Pharmacology, Pharmacy Keywords: contrast-induced nephropathy; hypoxia-inducible factor 2α; N-acetyl-cysteine; sildenafil

Online: 7 May 2018 (08:15:36 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0742.v1

A Network Comprised of miR-15b and miR-29a is Involved in VEGFA Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects

Adriana-Mariel Gentile, Said Lhamyani, Maria Mengual Mesa, Francisco Javier Pavón-Morón, John R Pearson, Julian Salas, Mercedes Clemente-Postigo, Lucia Perez Costillas, Gabriel Olveira, Rajaa El Bekay

Subject: Biology And Life Sciences, Aging Keywords: aging; angiogenesis; elderly; ischemia; microRNA; myocardial infarction; thymus adipose tissue; subcutaneous adipose tissue

Online: 12 September 2023 (07:09:18 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202307.1219.v1

Immunomodulatory and Antioxidant Drugs in Glaucoma Treatment

Francesco Buonfiglio, Norbert Pfeiffer, Adrian Gericke

Subject: Medicine And Pharmacology, Ophthalmology Keywords: autoimmune; glaucoma; retinal ganglion cell; optic nerve; inflammation; ischemia; oxidative stress; vascular dysregulation

Online: 18 July 2023 (11:37:09 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202208.0352.v1

A Novel Mitophagy Enhancer Protects Cardiomyocytes against Hypoxia/Reoxygenation

Xin Yan, Xiang Gao, Shanshan Hou, Steffen Jockusch, K Michael Gibson, Lanrong Bi

Subject: Chemistry And Materials Science, Medicinal Chemistry Keywords: Oxidative Stress, Free radical scavenging, Autophagy, Ischemia/reperfusion injury, Hypox-ia/reoxygenation, Mitophagy

Online: 18 August 2022 (14:33:17 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.0996.v1

Biomaterial Based Responsive Nanomedicines for Targeting Solid Tumor Microenvironment

Konstantinos Avgoustakis, Athina Angelopoulou

Subject: Chemistry And Materials Science, Biomaterials Keywords: biomaterials; tumor microenvironment; nanomedicine; hypoxia; acidosis; resistance; tumor vasculature; targeting; stimuli-responsiveness

Online: 14 December 2023 (03:08:59 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0097.v1

Hematological and Physiological Responses under Repeated Acute Hypoxia in Rainbow Trout (Onchorynchus mykiss)

Nuria Ruiz, Irene García-Meilán, Ali Reza Khansari, Mariana Teles, Josep Pastor, Lluis Tort

Subject: Biology And Life Sciences, Aquatic Science Keywords: repeated stress; hematology; fish; rainbow trout; hypoxia; dissolved oxygen concentration; RDW; cortisol

Online: 1 June 2023 (13:40:17 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202209.0457.v2

Synchronizing Cancer Research Worldwide, a Way of Overcoming Resistance to Anti-angiogenic Drugs

Kumara Swamy

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Anti-angiogenic; HIF-1 α; Normalization-window; research; hypoxia; resistance; SBRT; Immunotherapy

Online: 7 October 2022 (09:45:53 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0242.v1

Characterization of the pVHL Interactome in Human Testis Using High-Throughput Library Screening

Antonella Falconieri, Giovanni Minervini, Federica Quaglia, Geppo Sartori, Silvio C.E. Tosatto

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: VHL; von Hippel-Lindau syndrome; ubiquitination; hypoxia; testis; yeast two-hybrid (Y2H)

Online: 14 December 2021 (14:59:05 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202109.0511.v1

Oxygen, pH, Lactate, and Metabolism- How Old Knowledge and New Insights Might be Combined for New Wound Treatment

Herbert Leopold Haller, Frank Sander, Sebastian Philipp Nischwitz, Daniel Popp, Matthias Rapp, Bernd Hartmann, Mehmet Demircan, Lars Peter Kamolz

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: Wound; chronic wound; hypoxia; Lactate; Acidosis; Alkalosis; neoangiogenesis; ECM; Polylactide; polylactide membranes

Online: 30 September 2021 (12:18:52 CEST)

Show abstract| Download PDF| Share

: Over time, we have come to recognize a very complex network of physiological changes enabling wound healing. An immunological process enables the body to distinguish damaged cells and begin a cleaning mechanism by separating damaged proteins and cells with matrix metallopro-teinases, a complement reaction, and free radicals. A wide variety of cell functions help to rebuild new tissue, dependent on energy provision and oxygen supply. Like in an optimized "biorector," disturbance can lead to prolonged healing. One of the earliest investigated local factors is the pH of wounds, studied in close relation to the local perfusion, oxygen tension, and lactate concentration. Granulation tissue with the wrong pH can hinder fibroblast and keratinocyte division and pro-liferation, as well as skin graft takes. Methods for influencing the pH have been tested, such as occlusion and acidification by the topical application of acidic media. In most trials, this has not changed the wound's pH to an acidic one, but it has reduced the strong alkalinity of deeper or chronic wound. Energy provision is essential for all repair processes. New insights into the metabolism of cells have changed the definition of lactate from a waste product to an indispensable energy provider in normoxic and hypoxic conditions. Neovascularization depends on oxygen provision and lactate, signaling hypoxic conditions even under normoxic conditions. An appropriate pH is necessary for successful skin grafting; hypoxia can change the pH of wounds. This review describes the close interconnections between the local lactate levels, metabolism, healing mechanisms, and pH. Furthermore, it analyzes and evaluates the different possible ways to support metabolism, such as lactate enhancement and pH adjustment. The aim of wound treatment must be the optimization of all these components. Therefore, the role of lactate and its influence on wound healing in acute and chronic wounds will be assessed.

Preprint ARTICLE | doi:10.20944/preprints202011.0204.v1

Hypoxia-Induced ROS Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via HIF-1α/Mff Regulation

Kun Wu, Yuan-yuan Mao, Qi Chen, Bolin Zhang, Sheng Zhang, Han-jiang Wu, Yan Li

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: hypoxia; cisplatin sensitivity; mitochondrial fission; ROS; head and neck squamous cell carcinoma

Online: 5 November 2020 (10:02:19 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202003.0285.v1

Targeting HIF-1α Function in Cancer through the Chaperone Action of NQO1

Eduardo Salido, David J. Timson, Isabel Betancor-Fernández, Rogelio Palomino-Morales, Angel L. Pey

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: HIF-1α; NQO1; hypoxia; angiogenesis; cancer; protein:protein interactions; ligand binding; proteasomal degradation

Online: 18 March 2020 (08:45:33 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202302.0344.v1

Endothelial Function and Hypoxic-Hyperoxic Preconditioning in Coronary Surgery with a Cardiopulmonary Bypass: Randomized Clinical Trial

Irina A. Mandel, Yuriy K. Podoksenov, Sergey L. Mikheev, Irina V. Suhodolo, Yulia S. Svirko, Vladimir M. Shipulin, Andrey G. Yavorovskiy, Andrey I. Yaroshetskiy

Subject: Medicine And Pharmacology, Anesthesiology And Pain Medicine Keywords: oxygen transport; cardioprotection; hypoxic-hyperoxic preconditioning; ischemia-reperfusion injury; cardiopulmonary bypass; endothelial damage markers

Online: 20 February 2023 (15:14:26 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202309.0432.v1

Early Versus Late Caffeine and/or Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) for Prevention of Intermittent Hypoxia Induced Neuroinflammation in the Neonatal Rat

Myra Batool, Charles L. Cai, Jacob V. Aranda, Kay D. Beharry

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: Brain; Caffeine; Cytokines; Ibuprofen; Intermittent Hypoxia; Myelination; Neuroinflammation; Non-steroidal Anti-inflammatory Drugs

Online: 6 September 2023 (11:12:33 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202005.0284.v1

Hypoxia, Partial EMT and Collective Migration: Emerging Culprits in Metastasis

Kritika Saxena, Mohit Kumar Jolly, Kuppusamy Balamurugan

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: hypoxia; HIF-1α; partial EMT; collective migration; inflammatory breast cancer; E-cadherin; metastasis

Online: 17 May 2020 (08:19:42 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202305.1171.v1

Topical Application of Autologous Peripheral Blood Mononuclear Cells in Patients with Small Artery Disease and Diabetic Foot Ulcers: Efficacy, Safety and Economic Evaluation

Benedetta Ragghianti, Bianca Maria Berardi, Edoardo Mannucci, Matteo Monami

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Diabetes mellitus; Foot ulcer; Cell-therapy; Small Artery Disease; Chronic Limb-Threatening Ischemia; Economic evaluation

Online: 17 May 2023 (02:41:10 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.0420.v1

Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factors Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels

Martina Minisini, Emanuele Cricchi, Claudio Brancolini

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: Hypoxia; phosphorylation; HIF-1 alpha; HIF-2 alpha; HIF-3 alpha, acetylation; HDACs; KATs

Online: 7 December 2023 (06:16:42 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202303.0519.v1

Spatial-Temporal Distribution Characteristics and Interrelationship of Sulfur and Iron Compounds in Sediments: A Model Study in the Closed-Section of Mikawa Bay, Japan

Mitsuyasu Waku, Ryota Sone, Tetsunori Inoue, Toshiro Ishida, Teruaki Suzuki

Subject: Environmental And Earth Sciences, Water Science And Technology Keywords: dissolved sulfide; iron; hypoxia; buffering capacity; environmental restoration; coastal waters; Mikawa Bay; dead zone

Online: 30 March 2023 (02:58:33 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202206.0034.v1

Ca²⁺ Signaling and Hypoxia/Acidic Tumour Microenvironment Interplay in Tumour Progression

Madelaine Magalie Audero, Natalia Prevarskaya, Alessandra Fiorio Pla

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Ca2+ signaling; TRP channels; SOC channels; PIEZO channels tumour acidic microenvironment; hypoxia; tumour progression

Online: 2 June 2022 (11:10:23 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202011.0193.v1

Current Status of Cell-Based Therapy in Patients with Critical Limb Ischemia

Frantisek Jaluvka, Peter Ihnat, Juraj Madaric, Vaclav Prochazka

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Cell therapy, Peripheral arterial disease, Bone marrow, Adipose tissue, Mesenchymal stem cells, Exosome, Critical limb ischemia.

Online: 4 November 2020 (12:37:47 CET)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202308.1410.v1

Altered Blood Molecular Markers of Cardiovascular Function in Rats After Intrauterine Hypoxia and Drug Therapy

Olena Popazova, Igor Belenichev, Oleh Yadlovskyi, Valentyn OKsenych, Aleksandr Kamyshnyi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: prenatal hypoxia; cardioprotective; heat shock proteins; Angioli; L-arginine; Thiotriazoline; Mildronate; HSP70; HIF-1; eNOS

Online: 21 August 2023 (10:05:21 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202210.0450.v1

The Tumor Microenvironment in Tumorigenesis and Therapy Resistance Revisited

Kevin Dzobo, Dimakatso Senthebane, Collet Dandara

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Tumor microenvironment; stromal cells; immune cells; ECM; cancer hallmarks; hypoxia; exosomes; drug resistance; targeted therapy

Online: 28 October 2022 (09:57:34 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202202.0044.v1

Early Effects of Extracellular Vesicles Secreted by Adipose Tissue Mesenchymal Cells in Renal Ischemia Followed by Reperfusion: Mechanisms Rely on the Restoration of the Redox Tissular Environment

Jarlene A Lopes, Federica Collino, Clara Rodrigues-Ferreira, Luzia da Silva Sampaio, Glória Costa-Sarmento, Camila H.C. Wendt, Fernando P. Almeida, Kildare R. Miranda, Tais H. Kasai-Brunswick, Rafael S. Lindoso, Adalberto Vieyra

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: extracellular vesicles; mesenchymal cells; proximal tubular cells; renal ischemia/reperfusion; mitochondria; anion superoxide; acellular therapy; regenerative medicine

Online: 3 February 2022 (10:07:54 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202301.0420.v1

Hydrolytic Enzymes, Proteases, Permeases, and Transporters as Cryptococcus neoformans Weapons in Human Infections

Olufemi Samuel Folorunso, Olihile Moses Sebolai

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Cryptococcus; extracellular protease; biofilm, secretory vesicles; hypoxia; hydrolytic enzyme; homeostasis; transcription factors; membrane permeases; membrane transporters

Online: 24 January 2023 (03:08:39 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints202205.0030.v1

Right Ventricular Hypertrophy among COVID-19 Patients

Safia Haniya Yusuf, Jeffrey L. Ram

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: animal models; cardiac aftereffects; COVID-19; hypoxia; echocardiogram; pulmonary hypertension; right ventricular dilatation; right ventricular hypertrophy

Online: 5 May 2022 (09:36:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201911.0081.v1

The Zebrafish Xenograft Platform – A Novel Tool for Modeling KSHV-Associated Diseases

Eric S. Pringle, Jaime Wertman, Nicole Melong, Andrew J. Coombs, Andrew L. Young, David O'Leary, Chansey Veinotte, Carolyn-Ann Robinson, Michael N. Ha, Graham Dellaire, Todd Druley, Craig McCormick, Jason N. Berman

Subject: Biology And Life Sciences, Virology Keywords: Kaposi’s sarcoma-associated herpesvirus (KSHV); human herpesvirus-8; zebrafish; ddPCR; xenotransplantation; primary effusion lymphoma (PEL); hypoxia

Online: 8 November 2019 (03:23:22 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints201906.0301.v1

Tumor Angiogenic Inhibition Triggered Necrosis (TAITN) in Oral Cancer

Saori Yoshida, Hotaka Kawai, Taka Eguchi, Shintaro Sukegawa, May Oo, Chang Anqi, Kiyofumi Takabatake, Keisuke Nakano, Kuniaki Okamoto, Hitoshi Nagatsuka

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: tumor blood vessel; Tumor Angiogenic Inhibition Triggered Necrosis (TAITN); CXCR4 antagonist; oral squamous cell carcinoma; hypoxia

Online: 28 June 2019 (15:18:43 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201809.0364.v1

Current Landscape and the Potential Role of HIF and Selenium in Clear Cell Renal Cell Carcinoma Treatment

Rohan Garje, Josiah J. An, kevin Sanchez, Austin Greco, Jeffrey Stolwijk, Eric Devor, Youcef Rustum, Yousef Zakharia

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: clear cell renal cell carcinoma; hypoxia inducible factors (HIFs); selenium; PD-L1; miRNA; VEGF; mTOR inhibitors

Online: 19 September 2018 (05:10:22 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202312.1268.v1

Prevention of Delayed Graft Function in Kidney Transplant Recipients by Continuous Infusion of Prostaglandin-Analogue Iloprost: A Single-Center Prospective Study

Massimiliano Veroux*, Floriana Sanfilippo, Giuseppe Roscitano, Martina Maria Giambra, Alessia Giaquinta, Giordana Riccioli, Domenico Zerbo, Daniela Corona, Massimiliano Sorbello, Pierfrancesco Veroux

Subject: Medicine And Pharmacology, Transplantation Keywords: Kidney transplantation; Marginal Donor; Cold Ischemia Time; Donor Age; Acute kidney Injury; Deceased Donor; Graft Survival; Patient Survival

Online: 18 December 2023 (06:07:16 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202102.0384.v1

Prospects of Intraoperative Multimodal OCT Application in Patients With Acute Mesenteric Ischemia

Elena Kiseleva, Maxim Ryabkov, Mikhail Baleev, Evgeniya Bederina, Pavel Shilyagin, Vladimir Beschastnov, Ivan Romanov, Grigory Gelikonov, Natalia Gladkova

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: acute mesenteric ischemia (AMI); optical coherence tomography (OCT); optical coherence angiography (OCA); intraoperative diagnostics; gut vitality; image assessment

Online: 17 February 2021 (12:02:23 CET)

Show abstract| Download PDF| Share

Introduction: Despite the introduction of increasingly multifaceted diagnostic techniques and the general progress of emergency abdominal and vascular surgery, the outcome of treatment of patients with acute impaired intestinal circulation remains unsatisfactory. The non-invasive and high-resolution technique of optical coherence tomography (OCT) can be used intraoperatively to assess intestine viability and associated conditions that frequently emerge under conditions of impaired blood circulation. This study aims to demonstrate the effectiveness of multimodal (MM) OCT for intraoperative diagnostics of both the microstructure (cross-polarization OCT mode) and microcirculation (OCT angiography mode) of the small intestine wall in patients with acute mesenteric ischemia (AMI). Methods and Participants: A total of 18 patients were enrolled in the study. Nine of them suffered from AMI in segments II-III of the superior mesenteric artery (AMI group), where the ischemic segments of the intestine were examined. Nine others were operated for adenocarcinoma of the colon (control group), thus allowing areas of their normal small intestine to be examined for comparison. Data on the microstructure and microcirculation in the walls of the small intestine were obtained intraoperatively from the side of the serous membrane using the MM OCT system (IAP RAS, Russia) before bowel resection. The MM OCT data were compared with the results of histological examination. Results: The study finds that MM OCT visualized the damage to serosa, muscularis externa, and blood vessels localized in these layers in 100% of AMI cases. It also visualized the submucosa in 33.3% of AMI cases. The MM OCT image of non-ischemic (control group), viable ischemic and necrotic small intestines (AMI group) differed significantly across stratification of the distinguishable layers, the severity of intermuscular fluid accumulations and the type and density of the vasculature. Conclusion: The MM OCT diagnostic procedure optimally meets the requirements of emergency surgery. Data on the microstructure and microcirculation of the intestinal wall can be obtained simultaneously in real time without requiring contrast agent injections. The depth of visualization of the intestinal wall from the side of the serous membrane is sufficient to assess the volume of the affected tissues. However, the methodology for obtaining MM OCT data needs to be improved to minimize the motion artefacts generated in actual clinical conditions.

Preprint ARTICLE | doi:10.20944/preprints202305.2160.v1

Wavelet Analysis of Respiratory Muscle sEMG Signals During the Physiological Breakpoint of Static Dry End-Expiratory Breath-Holding in Naive Apneists: A Pilot Study

Nataša Ž. Mišić, Mirko Ostojić, Saša Cvetković, Petar Miodragović, Zdravko Aničić, Anita Popović, Đorđe Stefanović

Subject: Engineering, Electrical And Electronic Engineering Keywords: breath-holding; hypoxia; hypercapnia; involuntary breathing movement; muscle fiber subtypes; heart rate variability; wavelet analysis; multiresolution analysis

Online: 31 May 2023 (02:41:15 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202304.0538.v1

The Roles of Ral-Interacting Protein 76 and Vascular Endothelial Growth Factor in the Ovarian Corpus Luteum and Tumor Microenvironment

Tae-Hee Min, Seunghyung Lee

Subject: Biology And Life Sciences, Life Sciences Keywords: Ral-interacting protein 76; vascular endothelial growth factor; small GTPase; hypoxia-inducible factor-1; corpus luteum; tumor

Online: 19 April 2023 (04:10:47 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202210.0180.v1

Sustainability of C-Reactive Protein (CRP) Apheresis in Acute Myocardial Infarction (AMI) - Results from a Supplementary Data Analysis of the Explorative CAMI-1 Study

Horst Skarabis, Jan Torzewski, Wolfgang Ries, Franz Heigl, Christoph D. Garlichs, Rudolf Kunze, Ahmed Sheriff

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: C-reactive protein; STEMI; AMI; CRP apheresis; CMR; MRI; infarct size; inflammation; inflammatory mediators; ischaemia; hypoxia; phagocytosis

Online: 12 October 2022 (13:41:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202012.0112.v1

The Role of Hypoxia-Inducible Factor Post-Translational Modifications in Regulating its Localisation, Stability and Activity

Adam Albanese, Leonard A. Daly, Daniela Mennerich, Thomas Kietzmann, Violaine Sée

Subject: Biology And Life Sciences, Biochemistry And Molecular Biology Keywords: Hypoxia; HIF-1α; HIF-2α; Posttranslational modifications; Phosphorylation; Acetylation; Ubiquitination; Sumoylation; S-Nitrosylation; Signalling; cystein phosphorylation; methylation

Online: 4 December 2020 (13:45:45 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202005.0085.v1

COVID-19: Multiple Diseases Simulating Extreme High-Altitude Exposure? Oxygen Transport Physiology and Scarce Need of Ventilators; Andean Condor’s-Eye-View

Gustavo R. Zubieta-Calleja, Natalia Zubieta-DeUrioste, Thuppil Venkatesh, Kusal Das, Jorge Soliz

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: COVID-19; HAPE; high-altitude; tolerance to hypoxia; oxygen transport triad; Cov-2; SARS; pneumonia; ventilators; EPO

Online: 5 May 2020 (15:26:05 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202310.1240.v1

Advancements in Treatment Strategies for Chronic Mesenteric Ischemia: A Comprehensive Review

Genti Xhepa, Andrea Vanzulli, Lucilla Violetta Sciacqua, Agostino Inzerillo, Pierre Faerber, Anna Maria Ierardi, Gianpaolo Carrafiello, Filippo Del Grande, Alexis Ricoeur

Subject: Medicine And Pharmacology, Surgery Keywords: review; chronic mesenteric ischemia; superior mesenteric artery; revascularization; treatment; endovascular revascularization (ER); percutaneous transluminal angioplasty (PTA); primary stenting (PMAS)

Online: 19 October 2023 (10:14:50 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202308.0249.v1

Ultra-High Resolution Electrocardiography Enables Earlier Detection of Transmural and Subendocardial Myocardial Ischemia Compared to Conventional Electrocardiography

Kirill V. Zaichenko, Anna A. Kordyukova, Dmitry L. Sonin, Michael M. Galagudza

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: heart; ischemia; reperfusion; electrocardiography; ultra-high resolution electrocardiography; power spectral density; ischemic heart disease; subclinical atherosclerosis; sensitivity; risk stratification

Online: 3 August 2023 (05:17:42 CEST)

Show abstract| Download PDF| Share

Preprint COMMUNICATION | doi:10.20944/preprints202403.0753.v1

Noninvasive Ambulatory Electrocardiographic Markers from Patients with COVID-19 Pneumonia: A Report of Three Cases

Motohiro Kimata, Kenichi Hashimoto, Naomi Harada, Yusuke Kawamura, Yoshifumi Kimizuka, Yuji Fujikura, Mayuko Kaneko, Nobuaki Kiriu, Yasumasa Sekine, Natsumi Iwabuchi, Tetsuro Kiyozumi, Akihiko Kawana, Susumu Matukuma, Yuji Tanaka

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: ambulatory electrocardiographic markers; coronavirus disease-19; COVID-19; global cardiac ischemia; Holter electrocardiograph; myocardial remodeling; SARS-CoV-2; sudden cardiac death

Online: 13 March 2024 (07:31:31 CET)

Show abstract| Download PDF| Supplementary Files| Share

Preprint ARTICLE | doi:10.20944/preprints202309.2168.v1

Alterations in the amyloid protein precursor, α-secretase, β-secretase, presenilins and tau protein Genes in the CA3 Area of the Hippocampus in a 2-Year Ischemic Model of Alzheimer’s Disease

Stanisław Czuczwar, Janusz Kocki, Barbara Miziak, Jacek Bogucki, Anna Bogucka-Kocka, Ryszard Pluta

Subject: Biology And Life Sciences, Neuroscience And Neurology Keywords: brain ischemia; Alzheimer’s disease; CA3 area; amyloid protein precursor; amyloid; α-secretase; β-secretase; presenilin 1 and 2; tau protein; genes

Online: 30 September 2023 (08:01:45 CEST)

Show abstract| Download PDF| Share

Understanding the phenomena underlying the non-selective susceptibility to ischemia of py-ramidal neurons in the CA3 area of the hippocampus is important from the point of view of elu-cidating the mechanisms of memory loss and the development of post-ischemic dementia. We used an ischemic model of Alzheimer's disease to study changes in amyloid protein precursor gene expression, its cleavage enzymes and tau protein in the CA3 area of the hippocampus af-ter a 10-minute brain ischemia with 12, 18, and 24-month survival. Quantitative reverse tran-scriptase PCR assay showed that the expression of all the genes that contribute to amyloid pro-duction was dysregulated within 2 years in the CA3 area of the hippocampus after ischemia. The expression of the amyloid protein precursor gene was above the control values at all times of the study. The expression of the α-secretase gene also exceeded the control values throughout the study. In contrast, the expression of the β-secretase gene reaching its maximum increase 12 months after ischemia, was below control values after 18 months and again above control values after 24 months of survival. Presenilin 1 and 2 gene expression was significantly elevated throughout the follow-up period, with peak expression of both genes occurring 12 months after ischemia. This suggests that the genes studied are involved in the non-amyloidogenic processing of amyloid protein precursor. Also, tau protein gene expression was significantly elevated throughout the observation period, and peak gene expression was present 12 months after is-chemia. Data indicate that an episode of brain ischemia with long-term survival causes damage and death of pyramidal neurons in the CA3 area of the hippocampus in a manner dependent on modified tau protein. Thus defining a new and important mechanism of pyramidal neuronal death in the CA3 area after ischemia. In addition tau protein gene modification after brain is-chemia is useful in identifying ischemic mechanisms occurring in Alzheimer's disease.

Preprint REVIEW | doi:10.20944/preprints201806.0302.v1

UNDERSTANDING THE ROLE OF DYSFUNCTIONAL AND HEALTHY MITOCHONDRIA IN STROKE PATHOLOGY AND ITS TREATMENT

Hung Nguyen, Sydney Zarriello, Mira Rajani, Julian Tuazon, Eleonora Napoli, Cesar Borlongan

Subject: Biology And Life Sciences, Cell And Developmental Biology Keywords: cerebral ischemia, blood brain barrier, endothelial cells, impaired mitochondria, neurovascular unit, regenerative medicine, stem cell therapy, transfer of healthy mitochondria, vasculature

Online: 19 June 2018 (14:27:25 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202312.0465.v1

The Thirty-Fifth Anniversary of K+ Channels in O2 Sensing: What We Know and What We Don’t Know.

Asuncion Rocher, Philip Irving Aaronson

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: O2 sensing; carotid body; hypoxia; hypoxic pulmonary vasoconstriction; BKCa channel; KV channel; TASK channel; mitochondria; reactive oxygen species; redox

Online: 7 December 2023 (07:11:34 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202405.0063.v1

Paradoxes: Cholesterol and Hypoxia in Preeclampsia

Nancy R Hart

Subject: Other, Biology And Life Sciences Keywords: preeclampsia; hypoxia inducible factors; cholesterol; dietary lipids; Hedgehog (Hh); Wnt/β catenin; membrane biophysics; endothelial nitric oxide synthase; dyslipidemia; oxidative stress

Online: 1 May 2024 (08:09:17 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202212.0030.v1

Controls of Central and Peripheral Blood Pressure and Hemorrhagic/Hypovolemic Shock

Amaresh K. Ranjan, Anil Gulati

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Blood Pressure; Cardiovascular Disorder; Hypertension; Hypotension; Hypoxia; Baroreflex; Hemorrhagic Shock; Hypovolemic Shock; Vasopressure; Resuscitation; Centhaquine (Lyfaquin); Sympathetic System; Parasympathetic System; Adrenoreceptors

Online: 2 December 2022 (02:00:06 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201908.0186.v1

Roles of Extracellular Vesicles (EVs) Carrying HSPs in Cancer Biomarkers, Immune Surveillance, and Immune Evasion

Eman Taha, Kisho Ono, Takanori Eguchi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: heat shock protein (HSP); extracellular vesicle (EV); exosome; oncosome; immune evasion; resistance-associated secretory phenotype (RASP); EMT; hypoxia; biomarker; liquid biopsy

Online: 17 August 2019 (16:15:01 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202402.0256.v1

Identifying Hypoxia and Glycolysis in Chemotherapy- and Radiation-Induced Cardiotoxicity by Nuclear Medicine Diagnostic Imaging With 18F-Flurodeoxyglucose – Key Role of Coenzyme Q10 Deficiency in Acquired Mitochondrial Dysfunction

Roy Moncayo, Helga Moncayo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Coenzyme Q10; glycolysis; hypoxia; 18fluoro-desoxyglucose; 18F-FDG; positron emission tomography; BMIPP; fatty acid oxidation; baseline diagnosis; pediatric oncology; post-partum cardiomyopathy.

Online: 5 February 2024 (10:00:22 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202302.0107.v1

Non-invasive Assessment of Vascular Circulation Based on Flow Mediated Skin Fluorescence (FMSF)

Andrzej Marcinek, Joanna Katarzynska, Leslaw Sieron, Robert Skokowski, Jacek Zielinski, Jerzy Gebicki

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: flow mediated skin fluorescence; FMSF technique; NADH fluorescence; microcirculation; flowmo-tion; reactive hyperemia response; RHR; hypoxia sensitivity; HS; normoxia oscillatory index; NOI

Online: 7 February 2023 (02:14:48 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202204.0118.v1

SARS-CoV-2-Infection (COVID-19): Clinical Course and Cause(s) of Death

Giuliano Ramadori

Subject: Medicine And Pharmacology, Pathology And Pathobiology Keywords: SARS-CoV-2-infection; dehydration; hypoalbuminemia; pulmonary hypoxia; hyaline memrane; pulmonary engorgement; lung weight; acute respiratory distress syndrome; diffuse alveolar damage (DAD)

Online: 13 April 2022 (08:27:30 CEST)

Show abstract| Download PDF| Share

ABSTRACT Two years after first patients approached the emergency rooms of hospitals in Wuhan becouse of respiratory distress,thousend of SARS-CoV-2 infected persons continue to die every day worldwide.SARS-CoV-2-infected patients undergo a process of dehydration and malnutrition before they develop respiratory problems and approach the emergency room of a hospital.This is,in many cases, the consequence of high fever which causes massive loss of fluids. In addition loss of appetite, is responsible for the deficit of protein intake.Most of the virus-infected patients admitted to the emergency room are therefore hypovolemic and hypoproteinemic and suffer of respiratory distress accompanied by ground grass opacities at CT-scan of the lungs.Critically ill patients are treated following the guidelines for treatment of septic shock but with „conservative“ fluid replacement and administration of diuretics to assure sufficient hourly urine production. The combination of conservative fluid administration with reduced protein content in the enterally administered diet, together with administration of diuretics, has severe hemodynamic consequenses in mostly aged,dehydrated,critically ill patients. Many of them will develop acute kidney injury in the next 24 hours.In most of the cases, patients continue to loose weight by loosing skeletal muscle mass. Ischemic damage in the lung capillaries is responsible for the acute respiratory distreass syndrome (ARDS) and for the hallmark of autoptic findings,diffuse alveolar damage (DAD) characterized by hyaline membrane formation,fluid invasion of the alveoli recruitment of some inflammatory cells and progressive arrest of blood flow in the pulmonary vessels.The consequence is progressive congestion , increase of lung weight and progressive hypoxia (progressive severity of ARDS).Sequestration of blood in the lungs worsen hypovolemia and ischemia in different organs.This is most probably responsible for recruitment of inflammatory cells and for persistance of elevated serum levels of positive acute-phase markers and of hypoalbuminemia. Autoptic studies have been performed mostly in patients who died in the ICU after SARS-CoV-2-infection because of progessive ARDS.In those patients, tubulus epithelium necrosis in the kidney is a frequent finding as it has been the case in the first SARS-CoV-1 pandemic.In the death certification charts, many times weeks after first symptoms have started ,cardiac arrest is the cause of death after respitatory insufficiency.Replacement therapy with sufficient amount of fluid and albumin should be part of the early individualized life-saving supportive measures avoiding mechanical ventilation.

Preprint ARTICLE | doi:10.20944/preprints202404.1277.v1

Pulmonary Vascular Responses to Chronic Intermittent Hypoxia in a Guinea Pig Model of Obstructive Sleep Apnea

Elena Olea, Esther Valverde-Perez, Inmaculada Docio, Jesus Prieto-Lloret, Philip Irving Aaronson, Asuncion Rocher

Subject: Anatomy And Physiology, Medicine And Pharmacology Keywords: Systemic and pulmonary hypertension; intermittent hypoxia; hypoxic pulmonary vasoconstriction; carotid body; autonomic nervous system; obstructive sleep apnea; endothelial function; vessel remodeling; guinea pig

Online: 19 April 2024 (03:30:21 CEST)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202112.0041.v1

Genetics of Vascular Inflammation in Lower Limb Ischemia: The TNF-α Hypothesis in Peripheral Arterial Disease

Diego Caicedo, Clara V. Álvarez, Sihara Pérez, Jesús Devesa

Subject: Medicine And Pharmacology, Endocrinology And Metabolism Keywords: Vascular inflammation; Peripheral arterial disease (PAD); Chronic limb-threatening ischemia (CLTI); GHAS trial; TNF-α; hs-CRP; Neutrophil-to-lymphocyte ratio (NLR); NOX4; eNOS; VEGF-A.

Online: 3 December 2021 (09:44:42 CET)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202207.0171.v1

The Effects of Chronic Stress on Neuroanatomy and Cognitive Function

Niki Viradia, Jesica Godinez Paredes, Syed Hassan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s; aging; amygdala; brain plasticity; CA1; CA3; chronic stress; cognition; GABA; HIF-1; hippocampus; hypoxia; neurogenesis; Parkinson’s; prefrontal cortex; PSA-NCAM; ROS; spatial learning

Online: 12 July 2022 (04:25:55 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints201912.0386.v1

Exosome Release of Drugs: Coupling with Epithelial-Mesenchymal Transition

Takanori Eguchi, Kisho Ono, Stuart Calderwood, Kuniaki Okamoto

Subject: Medicine And Pharmacology, Pharmacology And Toxicology Keywords: resistance-associated secretory phenotype (RASP); extracellular vesicle (EV); exosome; oncosome; drug resistance; epithelial-mesenchymal transition (EMT); heat shock protein (HSP); cell stress response; hypoxia; acidosis; tumor immunology

Online: 29 December 2019 (13:46:21 CET)

Show abstract| Download PDF| Share

Preprint ARTICLE | doi:10.20944/preprints202306.0548.v1

Suppression of NASH-Related HCC by Farnesyltransferase Inhibitor Through Inhibition of Inflammation and Hypoxia-Inducible Factor-1α Expression

Kohei Yamada, Tomokazu Tanaka, Keita Kai, Shohei Matsufuji, Kotaro Ito, Yoshihiko Kitajima, Tatsuya Manabe, Hirokazu Noshiro

Subject: Medicine And Pharmacology, Gastroenterology And Hepatology Keywords: non-alcoholic steatohepatitis; hepatocellular carcinoma; farnesyltransferase inhibitor; hypoxia-inducible factor-1α; anti-inflammatory response; nuclear factor-κB; transforming growth factor-β; Warburg effect; reactive oxygen species; interleukin-6

Online: 7 June 2023 (12:05:28 CEST)

Show abstract| Download PDF| Supplementary Files| Share

Preprint REVIEW | doi:10.20944/preprints201805.0413.v1

A Current Overview of the Molecular Effects of Nanosilver

Shana J. Cameron, William G. Willmore

Subject: Biology And Life Sciences, Biophysics Keywords: silver nanoparticles; nanosilver; endocytosis; oxidative stress; reactive oxygen species; inflammation; wound healing; hypoxia; mitochondria; endoplasmic reticulum stress; unfolded protein response; autophagy; apoptosis; angiogenesis; epigenetics; genotoxicity; cancer; anti-cancer

Online: 28 May 2018 (15:51:12 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202206.0316.v1

The Stroma and Tumor Microenvironment Are Not the Most Instrumental Players in Tumor Cells Immune Evasion, Growth, and Resistance to Therapy

Hatem Tallima, Rashika El Ridi

Subject: Biology And Life Sciences, Immunology And Microbiology Keywords: Cancer surgery; Cancer radiotherapy; Cancer immunotherapy; Cancer stroma; Cancer-associated fibroblasts; Carcinogenesis; Cancer resistance to immunotherapy; Exosomes; Hypoxia; Neutrophil extracellular traps; Sphingomyelin; Neutral sphingomyelinase; Tumor microenvironment; Tumor-associated macrophages

Online: 22 June 2022 (10:25:07 CEST)

Show abstract| Download PDF| Share

Preprint REVIEW | doi:10.20944/preprints202111.0253.v1

Personalized Cell Therapy for Patients With Peripheral Arterial Diseases in the Context of Genetic Alterations: Artificial Intelligence-based Responder and Non-responder Prediction

Amankeldi Salybekov, Markus Wolfien, Shuzo Kobayashi, Takayuki Asahara

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Cell therapy; chronic limb-threating ischemia; peripheral artery disease; diabetes; atherosclerosis obliterans; thromboangiitis obliterans; personalized medicine; artificial intelligence; machine learning; genome-wide association studies; transcriptome-wide association studies; clonal hematopoiesis of indeterminate potential.

Online: 15 November 2021 (11:18:43 CET)

Show abstract| Download PDF| Share

Search Results

161 articles found