Version 1
: Received: 18 April 2023 / Approved: 19 April 2023 / Online: 19 April 2023 (04:10:47 CEST)
How to cite:
Min, T.; Lee, S. The Roles of Ral-Interacting Protein 76 and Vascular Endothelial Growth Factor in the Ovarian Corpus Luteum and Tumor Microenvironment. Preprints2023, 2023040538. https://doi.org/10.20944/preprints202304.0538.v1
Min, T.; Lee, S. The Roles of Ral-Interacting Protein 76 and Vascular Endothelial Growth Factor in the Ovarian Corpus Luteum and Tumor Microenvironment. Preprints 2023, 2023040538. https://doi.org/10.20944/preprints202304.0538.v1
Min, T.; Lee, S. The Roles of Ral-Interacting Protein 76 and Vascular Endothelial Growth Factor in the Ovarian Corpus Luteum and Tumor Microenvironment. Preprints2023, 2023040538. https://doi.org/10.20944/preprints202304.0538.v1
APA Style
Min, T., & Lee, S. (2023). The Roles of Ral-Interacting Protein 76 and Vascular Endothelial Growth Factor in the Ovarian Corpus Luteum and Tumor Microenvironment. Preprints. https://doi.org/10.20944/preprints202304.0538.v1
Chicago/Turabian Style
Min, T. and Seunghyung Lee. 2023 "The Roles of Ral-Interacting Protein 76 and Vascular Endothelial Growth Factor in the Ovarian Corpus Luteum and Tumor Microenvironment" Preprints. https://doi.org/10.20944/preprints202304.0538.v1
Abstract
Ral-interacting protein 76 (RLIP76) is a potential factor with vascular endothelial growth factor (VEGF) in the corpus luteum and tumor angiogenesis. RLIP76, VEGF, and hypoxia-inducible factor-1 (HIF-1) are proteins that activate angiogenic functions in tumor and endothelial cells. RLIP76 is a main factor in tumor growth, and VEGF is a major endothelial cell protein for angiogenesis. Also, RLIP76 regulates a small GTPase (R-Ras, oncogene) in cell survival, spreading, and migration. HIF-1 is important in the corpus luteum, tumor angiogenesis, and tumor growth. VEGF and HIF-1 regulate the angiogenic function of RLIP76, and RLIP76 controls vascular growth in endothelial and tumor cells. RLIP76, R-Ras, VEGF, and HIF-1 may be useful in the research of corpus luteum and cancer therapy and the study of mechanisms of tumor angiogenesis. This review will help to elucidate the roles of RLIP76/R-Ras and VEGF via HIF-1 in corpus luteum and tumor angiogenesis, tumorigenesis, and the specific regulation of RLIP76 in luteal, tumor, and endothelial cells. Thus, we reviewed the angiogenesis of the corpus luteum and tumor in the ovarian and tumor microenvironment.
Keywords
Ral-interacting protein 76; vascular endothelial growth factor; small GTPase; hypoxia-inducible factor-1; corpus luteum; tumor
Subject
Biology and Life Sciences, Life Sciences
Copyright:
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
