A Network Comprised of miR-15b and miR-29a is Involved in VEGFA Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects

Adriana-Mariel Gentile; Said Lhamyani; Maria Mengual Mesa; Francisco Javier Pavón-Morón; John R Pearson; Julian Salas; Mercedes Clemente-Postigo; Lucia Perez Costillas; Gabriel Olveira; Rajaa El Bekay

doi:10.20944/preprints202309.0742.v1

A peer-reviewed article of this Preprint also exists.

Gentile, A.M.; Lhamyani, S.; Mengual Mesa, M.; Pavón-Morón, F.J.; Pearson, J.R.; Salas, J.; Clemente-Postigo, M.; Pérez Costillas, L.; Fuster, G.O.; El Bekay Rizky, R. A Network Comprised of miR-15b and miR-29a Is Involved in Vascular Endothelial Growth Factor Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects. Int. J. Mol. Sci. 2023, 24, 14456. Gentile, A.M.; Lhamyani, S.; Mengual Mesa, M.; Pavón-Morón, F.J.; Pearson, J.R.; Salas, J.; Clemente-Postigo, M.; Pérez Costillas, L.; Fuster, G.O.; El Bekay Rizky, R. A Network Comprised of miR-15b and miR-29a Is Involved in Vascular Endothelial Growth Factor Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects. Int. J. Mol. Sci. 2023, 24, 14456.

Abstract

Adult human thymus degenerates into adipose tissue (TAT). In contrast to subcutaneous adipose tissue (SAT), TAT has been reported to exhibit enhanced angiogenic properties in elderly people. We have previously shown that vascular endothelial growth factor A (VEGFA) is the most abundant angiogenic growth factor in TAT of patients with ischemic cardiomyopathy (IC), and that VEGFA levels are increased in elderly (>70 years) compared with middle-aged patients. This makes TAT a promising candidate for angiogenic therapies and the regeneration of ischemic tissues following coronary surgery. MicroRNAs (miRNAs) have emerged as attractive therapeutic targets, especially those that regulate angiogenic processes. The study's purpose is to determine the miRNA network associated with both VEGFA pathway regulation and enrichment of age-linked angiogenesis in the TAT.

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A Network Comprised of miR-15b and miR-29a is Involved in VEGFA Pathway Regulation in Thymus Adipose Tissue from Elderly Ischemic Cardiomyopathy Subjects

Abstract

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