Review
Version 1
Preserved in Portico This version is not peer-reviewed
Immunomodulatory and Antioxidant Drugs in Glaucoma Treatment
Version 1
: Received: 17 July 2023 / Approved: 17 July 2023 / Online: 18 July 2023 (11:37:09 CEST)
A peer-reviewed article of this Preprint also exists.
Buonfiglio, F.; Pfeiffer, N.; Gericke, A. Immunomodulatory and Antioxidant Drugs in Glaucoma Treatment. Pharmaceuticals 2023, 16, 1193. Buonfiglio, F.; Pfeiffer, N.; Gericke, A. Immunomodulatory and Antioxidant Drugs in Glaucoma Treatment. Pharmaceuticals 2023, 16, 1193.
Abstract
Glaucoma, a group of diseases characterized by progressive retinal ganglion cell loss, cupping of the optic disc and by a typical pattern of visual field defects, is a leading cause of severe visual impairment and blindness worldwide. Elevated intraocular pressure (IOP) is the leading risk factor for glaucoma development. However, glaucoma can also develop at normal pressure levels. An increased susceptibility of retinal ganglion cells to IOP, systemic vascular dysregulation, endothelial dysfunction and autoimmune imbalances have been suggested to play a role in the pathophysiology of normal tension glaucoma. Since inflammation and oxidative stress play a role in all forms of glaucoma, the goal of this review article is to resent an overview on the inflammatory and prooxidant mechanisms in the pathophysiology of glaucoma and to discuss immunomodulatory and antioxidant treatment approaches.
Keywords
autoimmune; glaucoma; retinal ganglion cell; optic nerve; inflammation; ischemia; oxidative stress; vascular dysregulation
Subject
Medicine and Pharmacology, Ophthalmology
Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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