Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

Right Ventricular Hypertrophy among COVID-19 Patients

Version 1 : Received: 2 May 2022 / Approved: 5 May 2022 / Online: 5 May 2022 (09:36:47 CEST)

How to cite: Yusuf, S.H.; Ram, J.L. Right Ventricular Hypertrophy among COVID-19 Patients. Preprints 2022, 2022050030. Yusuf, S.H.; Ram, J.L. Right Ventricular Hypertrophy among COVID-19 Patients. Preprints 2022, 2022050030.


COVID-19 affects many organs in our body, including the heart and lungs. COVID-19 cases that require hospitalization often exhibit pulmonary hypertension (PH) due to changes in the lung microvasculature in which the blood vessels become stiff, damaged, or narrow, causing increased pulmonary arterial pressure. This review examines the hypothesis that PH can lead to right ventricular hypertrophy (RVH) as a long-lasting aftereffect of COVID-19. Recent studies have shown that significant percentages of hospitalized patients develop right ventricular hypertension and right ventricular dilatation (RVD), which may lead to right ventricular failure and death. Despite recommendations for echocardiogram reports to include right ventricular wall thickness to assess RVH, few published reports have reported this parameter. Relevant studies on animal models of PH in which the timing of PH can be precisely controlled suggest that one to three weeks of PH can cause RVH. Thus, according to the hypothesis proposed here COVID-19 patients who have long-lasting severe disease (e.g., needed to be on a ventilator for one or more weeks) accompanied by PH and RVD may develop RVH as a long-lasting sequela outlasting the infection itself. Echocardiogram studies of recovered COVID-19 patients may determine whether oft-reported cardiovascular sequelae include RVH.


animal models; cardiac aftereffects; COVID-19; hypoxia; echocardiogram; pulmonary hypertension; right ventricular dilatation; right ventricular hypertrophy


Medicine and Pharmacology, Cardiac and Cardiovascular Systems

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