ARTICLE
|
doi:10.20944/preprints202209.0179.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
polypharmacy; duplicate therapy; digital health; inappropriate prescribing; contraindicated drugs; drug-drug interactions; pharmacoepidemiology
Online: 13 September 2022 (12:25:42 CEST)
REVIEW
|
doi:10.20944/preprints202005.0411.v1
Subject:
Medicine And Pharmacology,
Epidemiology And Infectious Diseases
Keywords:
COVID-19; Clinical Trials; disruption; non-COVID-19 clinical trials; drugs; therapeutic area
Online: 25 May 2020 (11:17:56 CEST)
REVIEW
|
doi:10.20944/preprints202005.0003.v1
Subject:
Medicine And Pharmacology,
Dentistry And Oral Surgery
Keywords:
Anti-platelets; Anti-rheumatic drugs; Bisphosphonates; Oral anticoagulants; Oral contraceptives; Vitamin K antagonist
Online: 2 May 2020 (11:50:24 CEST)
ARTICLE
|
doi:10.20944/preprints202004.0161.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
COVID-19; SARS-CoV-2; main protease inhibition; virtual screening; drugs; natural products
Online: 9 April 2020 (14:59:37 CEST)
ARTICLE
|
doi:10.20944/preprints202002.0453.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Michael acceptor; safe covalent drugs; oxidative stress inducers; trans-cinnamaldehyde; curcumin; colorectal cancer
Online: 29 February 2020 (04:22:03 CET)
ARTICLE
|
doi:10.20944/preprints201909.0204.v1
Subject:
Public Health And Healthcare,
Health Policy And Services
Keywords:
Office of Innovation; novel drugs; novel therapies; regulatory science; Latin American Regulatory landscape
Online: 18 September 2019 (12:51:16 CEST)
ARTICLE
|
doi:10.20944/preprints202312.2072.v1
Subject:
Medicine And Pharmacology,
Tropical Medicine
Keywords:
Bothrops jararaca; Snakebite; Local Lesions; Inflammation; Leukocyte-endothelium interactions; Antivenom; Anti-inflammatory drugs; Microcirculation.
Online: 27 December 2023 (09:47:41 CET)
REVIEW
|
doi:10.20944/preprints202212.0564.v1
Subject:
Biology And Life Sciences,
Biology And Biotechnology
Keywords:
Physiologically Based Pharmacokinetic Model (PBPK); Drugs; environmental chemicals; Adverse outcome pathway (AOP); machine learning
Online: 30 December 2022 (01:30:07 CET)
ARTICLE
|
doi:10.20944/preprints202211.0516.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Antivirals; coronavirus; COVID-19; covalent drugs; dynamic light scattering; inhibitors; main protease; natural products
Online: 28 November 2022 (13:40:01 CET)
REVIEW
|
doi:10.20944/preprints202207.0250.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Emergence of Omicron and its mechanism; mutation and sub-lineages; Monoclonal antibodies; Antiviral drugs
Online: 18 July 2022 (07:48:00 CEST)
REVIEW
|
doi:10.20944/preprints202106.0040.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Anesthetic drugs and techniques, opioids, propofol, volatile agent, breast cancer, cancer recurrence, Biomarkers, miRNA.
Online: 1 June 2021 (15:06:42 CEST)
ARTICLE
|
doi:10.20944/preprints202008.0667.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Ovarian cancer; drug resistance; apoptosis; proteomics; combination; cytotoxicity; artemisinin; oleanolic acid; platinum drugs; cisplatin
Online: 30 August 2020 (12:06:32 CEST)
ARTICLE
|
doi:10.20944/preprints201907.0047.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
biomarker gene; doses of drugs; fold change gene expression; error rate; toxicity; hierarchical clustering
Online: 3 July 2019 (07:44:28 CEST)
REVIEW
|
doi:10.20944/preprints202404.0437.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
neurodegenerative diseases; Parkinson’ s disease; Alzheimer’ s disease; drug discovery; disease-modifying drugs
Online: 5 April 2024 (12:39:57 CEST)
ARTICLE
|
doi:10.20944/preprints202306.1149.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
platelets; blood coagulation; fibrin; thrombin generation; antiplatelet drugs; acetylsalicylic acid; ticagrelor; glycoprotein IIb-IIIa antagonists
Online: 15 June 2023 (13:13:19 CEST)
REVIEW
|
doi:10.20944/preprints202304.0933.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
Spirocycles; three-dimensional; high-Fsp3; spirocyclizations; cyclodehydration; ketalization; intramolecular Claisen condensation; intramolecular alkylation; approved drugs
Online: 26 April 2023 (03:09:08 CEST)
REVIEW
|
doi:10.20944/preprints202304.0812.v1
Subject:
Chemistry And Materials Science,
Organic Chemistry
Keywords:
medicinal plants; ethnopharmacology; skin diseases; flora of Kazakhstan; atopic dermatitis; plant drugs; anti-inflammatory activity
Online: 24 April 2023 (03:49:43 CEST)
ARTICLE
|
doi:10.20944/preprints202106.0709.v1
Subject:
Social Sciences,
Psychology
Keywords:
drugs; perception of controlling drug use; drug use control strategies; risk and harm reduction approach
Online: 29 June 2021 (13:23:18 CEST)
REVIEW
|
doi:10.20944/preprints202009.0732.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Rosemary; Alzheimer’s disease; cognition; meta-analysis; preclinical study; mild cognitive dysfunction; herbal drugs; rosmarinic acid
Online: 30 September 2020 (10:04:01 CEST)
ARTICLE
|
doi:10.20944/preprints201912.0022.v1
Subject:
Physical Sciences,
Optics And Photonics
Keywords:
direct laser processing; femtosecond laser pulses; superhydrophobic textures; analyte enrichment; plasmonic nanostructures; SERS; medical drugs
Online: 3 December 2019 (11:19:55 CET)
REVIEW
|
doi:10.20944/preprints202401.0523.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
antibodies; biologics; chemical entities; fluorine-based drugs; imaging; natural products; new chemical entities; oligonucleotides; peptides; TIDES
Online: 8 January 2024 (09:44:44 CET)
ARTICLE
|
doi:10.20944/preprints202311.1379.v1
Subject:
Medicine And Pharmacology,
Pharmacy
Keywords:
antibacterial activity; antistaphylococcal synergistic effect; methicillin resistant S. aureus; musculoskeletal infections; non-steroidal anti-inflammatory drugs
Online: 22 November 2023 (06:33:47 CET)
REVIEW
|
doi:10.20944/preprints202305.0014.v1
Subject:
Public Health And Healthcare,
Physical Therapy, Sports Therapy And Rehabilitation
Keywords:
HBV/HDV coinfection; Evolving antiviral drugs; innovative immune therapeutic agents; combination of antiviral and immune therapy
Online: 1 May 2023 (04:18:06 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0310.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
COVID-19; CoviRx.org; database; drugs; pandemic; repurposing; SARS-CoV-2; therapies; treatments; Variants of Concern (VOC)
Online: 20 September 2022 (15:00:48 CEST)
ARTICLE
|
doi:10.20944/preprints202209.0188.v1
Subject:
Chemistry And Materials Science,
Medicinal Chemistry
Keywords:
MTBC; virtual screening; topological indices; linear discriminant analysis; pharmacological activity distribution diagrams; antimicrobial drugs; drug design
Online: 14 September 2022 (03:32:55 CEST)
REVIEW
|
doi:10.20944/preprints202108.0065.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
type 2 diabetes mellitus (T2DM); older people; frailty; antidiabetic drugs; comprehensive geriatric assessment; therapeutic targets; hypoglycemia.
Online: 3 August 2021 (09:07:51 CEST)
REVIEW
|
doi:10.20944/preprints202011.0372.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
SARS-CoV-2; Covid-19; Antiviral Drugs; Immunomodulators; Neutralizing Antibody Therapy; Cell Therapy; Current Vaccine Stage
Online: 13 November 2020 (12:30:08 CET)
ARTICLE
|
doi:10.20944/preprints202002.0022.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
influenza B virus; mammalian adaptation; amino acid substitutions; pathogenicity; influenza model; animal model; virulence; antiviral drugs
Online: 3 February 2020 (06:24:05 CET)
ARTICLE
|
doi:10.20944/preprints201703.0050.v1
Subject:
Chemistry And Materials Science,
Physical Chemistry
Keywords:
mefenamic acid; diamond anvil cell; high-pressure; polymorphism; high-pressure crystallization; non-steroidal anti-inflammatory drugs
Online: 8 March 2017 (08:58:38 CET)
ARTICLE
|
doi:10.20944/preprints202403.0457.v1
Subject:
Medicine And Pharmacology,
Veterinary Medicine
Keywords:
Newcastle disease virus; natural compounds; antiviral drugs; NDV; MD simulation; Hemagglutinin Neuraminidase; biological activity; ADMET; pharmacophore; screening
Online: 8 March 2024 (03:56:28 CET)
REVIEW
|
doi:10.20944/preprints202401.2185.v1
Subject:
Biology And Life Sciences,
Virology
Keywords:
Avian Influenza; Pandemic Management; Epidemiology; Virology; Pathogenesis; Antiviral Drugs; Influenza Vaccines; Immune Response; Antigenic Drift; Antigenic Shift
Online: 31 January 2024 (08:04:16 CET)
ARTICLE
|
doi:10.20944/preprints202306.0784.v1
Subject:
Medicine And Pharmacology,
Neuroscience And Neurology
Keywords:
antiepileptic drugs; age; autism spectrum disorder; epilepsy; ketogenic diet; mitochondrial dysfunction; modified Atkins diet; neurodevelopmental regression, seizures
Online: 12 June 2023 (07:23:54 CEST)
ARTICLE
|
doi:10.20944/preprints202105.0546.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
triple negative breast cancer; Pembrolizumab; Atezolizumab; chemotherapy; anti-PD-L1; biomarkers; targeted therapies; development of novel drugs
Online: 24 May 2021 (09:23:50 CEST)
ARTICLE
|
doi:10.20944/preprints201812.0018.v2
Subject:
Biology And Life Sciences,
Biochemistry And Molecular Biology
Keywords:
colorectal cancer; differentially expressed genes; biomarkers; protein-protein interaction; reporter biomolecules; candidate drugs; systems biology; drug repositioning
Online: 29 December 2018 (07:05:05 CET)
ARTICLE
|
doi:10.20944/preprints202404.1441.v1
Subject:
Complementary And Alternative Medicine,
Medicine And Pharmacology
Keywords:
essential oils; GC-MS; antibacterial activity; gram-positive and gram-negative bacteria; diffusimetric antibiogram; antibacterial drugs; combinations; interactions
Online: 23 April 2024 (12:52:32 CEST)
ARTICLE
|
doi:10.20944/preprints202103.0267.v2
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
Scanning acoustic microscopy; speed of sound; attenuation of sound; anticancer drugs; tannic acid; acetic acid; microwave; Computer Imaging
Online: 11 March 2021 (11:25:34 CET)
REVIEW
Subject:
Biology And Life Sciences,
Animal Science, Veterinary Science And Zoology
Keywords:
Stress; fear; anxiety; aggression; veterinary visit; low-stress handling; counterconditioning; behaviour modification; anxiolytic medication; psychoactive drugs; dogs; cats
Online: 8 January 2021 (14:37:01 CET)
COMMUNICATION
|
doi:10.20944/preprints202403.0296.v1
Subject:
Environmental And Earth Sciences,
Other
Keywords:
detection technology of drugs in urban sewage; magnetic solid phase extraction; acoustic ejection mass spectrometry analysis method; fast detection
Online: 6 March 2024 (11:08:13 CET)
REVIEW
|
doi:10.20944/preprints202401.1465.v1
Subject:
Biology And Life Sciences,
Behavioral Sciences
Keywords:
intracranial self-stimulation; brain-stimulation reward; optogenetics; optical ICSS;
reward; aversion; drugs of abuse; new psychoactive substances
reward; aversion; drugs of abuse; new psychoactive substances
Online: 19 January 2024 (07:08:28 CET)
ARTICLE
|
doi:10.20944/preprints202309.1300.v1
Subject:
Biology And Life Sciences,
Toxicology
Keywords:
semaglutide; drug misuse; drug abuse; pharmacovigilance; image- and performance-enhancing (IPED) drugs; glucagon-like peptide-1 (GLP-1) agonists
Online: 20 September 2023 (05:05:11 CEST)
ARTICLE
|
doi:10.20944/preprints202306.0611.v1
Subject:
Medicine And Pharmacology,
Medicine And Pharmacology
Keywords:
semaglutide; drug misuse; drug abuse; pharmacovigilance; image- and performance-enhancing (IPED) drugs; glucagon-like peptide-1 (GLP-1) agonists
Online: 8 June 2023 (09:01:58 CEST)
REVIEW
|
doi:10.20944/preprints202102.0193.v1
Subject:
Biology And Life Sciences,
Anatomy And Physiology
Keywords:
mild cognitive impairment (MCI); mild dementia; Alzheimer’s disease; Ginkgo biloba (EGb761®); Tebonin; anti-dementia drugs; randomized controlled trials
Online: 8 February 2021 (11:37:05 CET)
ARTICLE
|
doi:10.20944/preprints202011.0616.v1
Subject:
Medicine And Pharmacology,
Immunology And Allergy
Keywords:
action potential; atrial fibrillation; in silico model; population of models; Class I antiarrhythmic drugs; flecainide; disopyramide; quinidine; propafenone; Pitx2
Online: 24 November 2020 (13:28:26 CET)
ARTICLE
|
doi:10.20944/preprints202005.0199.v1
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
SARS-CoV-2; COVID-19; CADD; virtual screening; approved drugs; drug repurposing; essential targets; molecular docking; molecular dynamics simulations
Online: 11 May 2020 (13:14:18 CEST)
COMMUNICATION
|
doi:10.20944/preprints202002.0418.v2
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
virtual screening; molecular docking; drug repurposing; drug repositioning; anti-viral drugs; Coronavirus; COVID-19; 2019-nCoV; SARS-CoV-2
Online: 9 March 2020 (02:29:04 CET)
ARTICLE
|
doi:10.20944/preprints202401.1005.v1
Subject:
Biology And Life Sciences,
Neuroscience And Neurology
Keywords:
designer receptors exclusively activated by designer drugs (DREADDs); infralimbic cortex; sleep; stress; transcranial direct current stimulation (tDCS); ventrolateral preoptic area
Online: 15 January 2024 (02:28:51 CET)
ARTICLE
|
doi:10.20944/preprints202202.0300.v1
Subject:
Chemistry And Materials Science,
Analytical Chemistry
Keywords:
Electrochemical sensors; square-wave voltammetry; screen-printed electrodes; electrochemical profiling; illicit drugs; forensic analysis; Raman spectrometer; on-site detection; FTIR spectrometer
Online: 24 February 2022 (04:00:15 CET)
ARTICLE
Subject:
Medicine And Pharmacology,
Pharmacology And Toxicology
Keywords:
skin sensitization potential; prediction; in silico models; machine learning; local lymph node assay (LLNA); cosmetics; drugs; pesticides; chemical space; applicability domain
Online: 29 August 2019 (04:38:16 CEST)
REVIEW
|
doi:10.20944/preprints202312.1480.v1
Subject:
Chemistry And Materials Science,
Nanotechnology
Keywords:
Nano-drugs; Nanoparticle; Delivery System; Vaccine; Liposome; Exosome; Stealth Effect; SLN; Inclusion and Dispersion Systems; Solid State Reactive Mixing; Nanosome; Drug Carrier
Online: 20 December 2023 (10:54:31 CET)
REVIEW
|
doi:10.20944/preprints201807.0525.v2
Subject:
Medicine And Pharmacology,
Gastroenterology And Hepatology
Keywords:
4-Hydroxynonenal; lipid peroxidation; redox balance; oxidative stress; stomach; peptic ulcer; gastritis; Helicobacter pylori; gastric cancer; non-steroid anti-inflammatory drugs-induced gastropathy
Online: 23 August 2018 (04:24:43 CEST)
CASE REPORT
|
doi:10.20944/preprints202402.0716.v1
Subject:
Medicine And Pharmacology,
Orthopedics And Sports Medicine
Keywords:
Sinus Tarsi syndrome; Heel pain; Extracorporeal pulse-activated therapy (EPAT); Standard-of-care treatments; Non-steroidal anti-inflammatory drugs (NSAIDs); Foot orthosis; Laser therapy
Online: 13 February 2024 (08:01:19 CET)
REVIEW
|
doi:10.20944/preprints202302.0030.v1
Subject:
Medicine And Pharmacology,
Oncology And Oncogenics
Keywords:
angiogenesis inhibitors; VEGF inhibitors; ovarian cancer; progression-free survival; overall sur-vival; toxicity; systematic review; meta-analysis; randomized controlled trials; FDA approval of cancer drugs
Online: 2 February 2023 (05:26:47 CET)
ARTICLE
|
doi:10.20944/preprints202402.1524.v1
Subject:
Biology And Life Sciences,
Immunology And Microbiology
Keywords:
Coccomyxa subellipsoidea KJ; metallothioneins; Th17 cytokines; T cell activation; immunoregulation; transcriptome analysis; peripheral blood mononuclear cells; inflammatory factors; toxic shock syndrome toxin-1; immune regulatory drugs
Online: 27 February 2024 (10:26:51 CET)