Preprint Review Version 1 Preserved in Portico This version is not peer-reviewed

A Systematic Review on the Emergence of Omicron Variant and Recent Advancement in Therapies

Version 1 : Received: 16 July 2022 / Approved: 18 July 2022 / Online: 18 July 2022 (07:48:00 CEST)

How to cite: Pandey, R.P.; konyak, M.B.; Sharma, M.; Kharia, S.; Chang, C. A Systematic Review on the Emergence of Omicron Variant and Recent Advancement in Therapies . Preprints 2022, 2022070250 (doi: 10.20944/preprints202207.0250.v1). Pandey, R.P.; konyak, M.B.; Sharma, M.; Kharia, S.; Chang, C. A Systematic Review on the Emergence of Omicron Variant and Recent Advancement in Therapies . Preprints 2022, 2022070250 (doi: 10.20944/preprints202207.0250.v1).

Abstract

With the ongoing COVID pandemic, the emergence of a novel omicron variant in November 2021 has chaos the world. Despite mass vaccination, this omicron has spread rapidly raising concerns around the globe. The Omicron variant has a vast array of mutations as compared to another variant of concern with overall 50 mutations where 30 mutations are present in its spike protein. This mutation has led to immune escape and more transmissibility compared to other variants, including Delta. A cluster of mutations (H655Y, N679K, and P681H) present at the omicron spike protein could aid in transmission. Currently, no virus-specific data are available to predict the efficacy of anti-viral and mAbs drugs. However, two monoclonal antibody drugs: Sotrovimab and Evusheld are authorized for emergency use in COVID patients. This virus is not fading away soon. The easiest solution and less expensive measure to fight against this pandemic are following COVID appropriate protocols.There is need to strengthen the level of research for development of potential vaccines and anti-viral drugs. It is also important to monitor and expand genomic surveillance to keep track of the emergence of new variants thus avoiding the spread of new diseases worldwide. This article highlights the emergence of omicron and vast number of mutation in its protein. In addition, recent advancement in drugs approved by FDA to treat COVID patients has been listed and focused in this paper.

Keywords

Emergence of Omicron and its mechanism; mutation and sub-lineages; Monoclonal antibodies; Antiviral drugs

Subject

LIFE SCIENCES, Virology

Comments (0)

We encourage comments and feedback from a broad range of readers. See criteria for comments and our diversity statement.

Leave a public comment
Send a private comment to the author(s)
Views 0
Downloads 0
Comments 0
Metrics 0


×
Alerts
Notify me about updates to this article or when a peer-reviewed version is published.

We use cookies on our website to ensure you get the best experience.
Read more about our cookies here.