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Preprint ARTICLE | doi:10.20944/preprints202004.0345.v1

Incidence of Venous Thromboembolism in Hospitalized Patients with COVID-19

Saskia Middeldorp, Michiel Coppens, Thijs F. van Haaps, Merijn Foppen, Alexander P. Vlaar, Marcella C.A. Muller, Catherine C.S. Bouman, Ludo F.M. Beenen, Ruud S. Kootte, Jarom Heijmans, Loek P. Smits, Peter I. Bonta, Nick van Es

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19; venous thrombosis; pulmonary embolism; venous thromboembolism; anticoagulants; mortality

Online: 19 April 2020 (13:08:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1080.v1

Choice and Duration of Anticoagulation for Venous Thromboembolism

Geoffrey D Barnes, Aroosa Malik, Nghi B Ha

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Venous Thromboembolism; Pulmonary Embolism; Deep Vein Thrombosis; Anticoagulation; cardio-vascular disease

Online: 14 December 2023 (10:49:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.1469.v1

Venous Thromboembolism (VTE) in Post-prostatectomy Patients- Systematic Review and Meta-Analysis

Mudassir Wani, Abdullah Al-Mitwalli, Subhabrata Mukherjee, Ghulam Nabi, Bhaskar K. Somani, Jayasimha Abbaraju, Sanjeev Madaan

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: Prostate cancer; Radical prostatectomy; Venous thromboembolism,; Mechanical prophylaxis; Pharmacological prophylaxis

Online: 22 May 2023 (07:12:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.1606.v1

System-wide Thromboprophylaxis Interventions for Hospitalized Patients at Risk of Venous Thromboembolism: Focus on Cross-Platform Clinical Decision Support

Nikolaos Tsaftaridis, Mark Goldin, Alex C Spyropoulos

Subject: Medicine And Pharmacology, Internal Medicine Keywords: Venous Thromboembolism; Clinical Decision Support Tools; Thromboprophylaxis; Hospitalized Patients; Electronic Health Records

Online: 28 February 2024 (08:06:12 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202409.2238.v1

Extensive Bilateral Pulmonary Embolism Secondary to Uterine Fibroid Induced Iliac Vein Compression; Case Report

Mustafa Alkhawam, Benjamin Matthews, Weihan Chen, Mouhamed Amr Sabouni, Samuel K McElwee

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Uterine fibroid; Venous thromboembolism; pulmonary embolism; Venous stasis; Hysterectomy

Online: 27 September 2024 (15:08:09 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202209.0035.v2

Application of Amniotic Membrane Allografts in Advanced Venous Leg Ulcer: A Case Study and Literature Review

Naomi Lambert, Eric Vinke, Tyler Barrett, Matthew Regulski

Subject: Biology And Life Sciences, Biology And Biotechnology Keywords: Chronic Venous Insufficiency; Venous Leg Ulcer; Dehydrated Amniotic Membrane Allograft

Online: 5 September 2022 (10:57:27 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202008.0203.v1

Single-Session treatment of Upper Extremity Deep Venous Thrombosis and Central Venous Catheter Malfunction using INARI ClotTriever

Siddharth Agarwal, Christopher Sosnofsky, Manu B. Aggarwal, Jamie Saum, Sandeep M. Patel

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: Percutaneous mechanical thrombectomy; ClotTriever; Upper extremity deep venous thrombosis; Central venous catheter

Online: 8 August 2020 (04:10:47 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202307.0077.v1

Syndrome Sinistre: Left Brachiocephalic Vein Compression and its Neurological Manifestations.

Karthikeyan M. Arcot, Vincent S. DeOrchis

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Venous Outflow Obstruction Brachiocephalic Vein

Online: 3 July 2023 (12:53:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0113.v1

Usefulness of Serial Multiorgan Point-of-Care Ultrasound in Acute Heart Failure: Results from a Prospective Observational Cohort

Marta Torres-Arrese, Gonzalo García de Casasola-Sánchez, Manuel Méndez-Bailón, Esther Montero-Hernández, Marta Cobo-Marcos, Mercedes Rivas-Lasarte, Luis Caurecel-Díaz, Pablo Rodríguez-Fuertes, Tomas Villén-Villegas, Yale Tung-Chen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: acute heart failure (AHF); venous congestion; Point-of-Care Ultrasound (POCUS); VExUS (venous excess ultrasonography score).

Online: 7 December 2021 (23:46:59 CET)

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Background and Objectives: Acute Heart Failure (AHF) is a common disease and a cause of high morbidity and mortality, constituting a major health problem. The main purpose of this study was to determine the impact of multiorgan ultrasound in identifying the pulmonary hypertension (PH) in patients admitted due to AHF, predict the evolution of the disease during hospitalization and identify areas of improvement in the care of patients with AHF. Materials and Methods: Patients were evaluated with a standard exam of lung ultrasound, echocardiography, inferior vena cava (IVC) and femoral, renal, hepatic, portal venous Doppler flow patterns at admission and on the day of discharge. Results: Thirty patients were enrolled during November 2021. The mean age was seventy-nine years (Standard Deviation – SD 13,4). Seven patients (23.3%) had a renal function worsening. Regarding ultrasound findings, venous excess ultrasonography score (VExUS) score was calculated at admission and at discharge, surprisingly remaining unchanged or even worsened in most of them (21 patients, 70.0%). The area under the curve for the Lung Score was 83.9% (p = 0.008), obtaining a cutoff value of 10 that showed a sensitivity of 82.6% and a specificity of 71.4% in the identification of intermediate and high PH. It was possible to monitor significant changes between both exams on the lung score (p <0.001), hepatic vein Doppler (p <0.001), portal vein Doppler (p = 0.030), intra-renal vein Doppler (p = 0.025) and VExUS score (p = 0.023), remaining similar the femoral vein Doppler (p = 0.177) and IVC (p = 0.132). Conclusions: Our study results suggest that performing serial multiorgan Point-of-Care ultrasound can help us to better identify high and intermediate probability of PH patients with AHF. Currently proposed multi-organ, venous Doppler scanning protocols, such as the VExUS score, should be further studied in different populations before expanding its use in AHF patients.

Preprint ARTICLE | doi:10.20944/preprints202307.1450.v1

Thrombin Generation is Associated with Venous Thrombo-embolism Recurrence, but not with Major Bleeding and Death in the Elderly: A Prospective Multicenter Cohort Study

Kristina Vrotniakaite-Bajerciene, Sereina Rütsche, Sara Calzavarini, Claudia Quarroz, Odile Stalder, Marie Méan, Marc Righini, Daniel Staub, Juerg H. Beer, Beat Frauchiger, Joseph Österwalder, Nils Kucher, Christian M. Matter, Marc Husmann, Martin Banyai, Markus Aschwanden, Lucia Mazzolai, Olivier Hugli, Nicolas Rodondi, Drahomir Aujesky, Anne Angelillo-Scherrer

Subject: Medicine And Pharmacology, Hematology Keywords: Thrombin generation; venous thromboembolism; elderly; bleeding; mortality

Online: 21 July 2023 (12:46:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202111.0161.v1

Risk Factors Associated with the Development of Metastases in Patients with Gastroenteropancreatic Neuroendocrine Tumors

Shuzo Kohno, Masahiro Ikegami, Toru Ikegami, Hiroaki Aoki, Masaichi Ogawa, Fumiaki Yano, Ken Etoh

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: neuroendocrine tumor; metastasis; lymphatic invasion; venous invasion

Online: 9 November 2021 (08:30:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1220.v1

Cyanoacrylate Glue for Treating Chronic Saphenous Vein Insufficiency: A Retrospective Observational Single-Center Study

Nicolas Falvo, Amine Latreche, Olivier Chevallier, Frédérik Ledan, Maud Jandot, Héla Daoud, Léo Fréchier, Romaric Loffroy

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: endovenous cyanoacrylate ablation; venous insufficiency; quality of life

Online: 16 June 2023 (10:34:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.1900.v1

Prognostic Value of Separate Extramural Vascular Invasion Reporting in Operative Samples of Rectal Cancer: Single-Institutional Experience

Mladen Đurić, Bojana Kožik, Tijana Vasiljević, Aleksandar Đermanović, Nevena Stanulović, Marina Đurić

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Rectal cancer (RC); Extramural venous invasion (EMVI); Predictive Medicine

Online: 24 September 2024 (14:04:05 CEST)

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Background/Objectives: Vascular invasion, especially extramural vascular invasion (EMVI) has emerged as prognostic parameter for rectal cancer (RC) in recent years. Prediction of reccurence and metastases development poses a significant challenge for oncologists, needing markers for prediction of adverse outcome. The aim of this study was to examine the prognostic significance of pathohistologically detected EMVI in untreated rectal cancer and its implications in separate reporting. Methods: We examined 100 untreated RC patients who underwent curative resection from January 2016 to June 2018 with follow up of 5 years. Patients were divided in equal EMVI- and EMVI+ groups based on histological re-examination of H&E stained postoperative surgical samples. Results: The presence of EMVI within the selected cohort was significantly associated with female gender, T3/T4 and N1/N2 post-operative stages, positive lymph nodes, lymph node ratio LNR2 and LNR3 groups, abundant tumor-infiltrating lymphocytes, positive lympho-vascular invasion (LVI), perineural (PNI), and circumferential resection margin (CRM) (p<0.05 in all tests). Within EMVI+ patients, local recurrences and/or metastases, and death outcomes were more frequent events (p=0.029 and p=0.035, respectively), while survival analyses revealed that EMVI+ patients had significantly shorter overall survival (OS, p=0.040) and disease-free survival (DFS, p=0.028). Concerning LVI, differences in OS between LVI+ and LVI- patients were not statistically significant (p=0.068), while LVI+ patients had significantly shorter DFS (p=0.024). Moreover, univariate COX regression analysis demonstrated the negative impact of EMVI on OS (HR: 2.053, 95% CI: 1.015-4.152; p=0.045) and DFS (HR: 2.106, 95% CI: 1.066-4.870; p=0.038), which was not the case for LVI+ RC patients. Conclusions: Obtained results strongly suggest significance of separate reporting of EMVI from lympho-vascular invasion, as it is potentially a surogate marker for adverse prognosis and outcome.

Preprint REVIEW | doi:10.20944/preprints202409.0782.v1

The Basic Principles of Pathophysiology of Venous Thrombosis

Sam Schulman, Alexander Makatsariya, Jamilya Khizroeva, Viсtoria Bitsadze, Daredzhan Kapanadze

Subject: Medicine And Pharmacology, Hematology Keywords: venous thromboembolism; hypoxia; stasis; cytokines; neutrophil extracellular traps; complements

Online: 10 September 2024 (09:32:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0085.v1

Clinical Significance of Early Venous Filling Detected via Preoperative Angiography in Glioblastoma

Kotaro Tatebayashi, Noriyuki Nakayama, Daisuke Sakamoto, Tomoko Iida, Shun Ono, Ikuo Matsuda, Yukiko Enomoto, Michihiro Tanaka, Mitsugu Fujita, Seiichi Hirota, Shinichi Yoshimura

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: glioblastoma; early venous filling; arteriovenous shunt; vascular mimicry; Avastin

Online: 3 July 2023 (12:47:58 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202306.1673.v1

Unintentional Two-Stage Surgery of Hypervascular Choroid Plexus Papilloma considering Venous Drainage: A Case Report

Daishiro Abe, Kohei Kanaya, Takafumi Kiuchi, Sumio Kobayashi, Kenji Sano, Tetsuyoshi Horiuchi

Subject: Medicine And Pharmacology, Surgery Keywords: choroid plexus papilloma; hypervascular tumor; surgical strategy; venous drainage

Online: 23 June 2023 (12:00:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0168.v1

Development and Validation of the Cvp-Score: A Cross-Sectional Study in Greece

Konstantinos Giakoumidakis, Athina Patelarou, Anastasia A. Chatziefstratiou, Michail Zografakis-Sfakianakis, Nikolaos V. Fotos, Evridiki Patelarou

Subject: Public Health And Healthcare, Nursing Keywords: Central venous pressure; intensive care units; questionnaire; reliability; validity

Online: 10 April 2023 (10:27:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0309.v1

FONDENOXAVID: A Retrospective Analysis on Utility of Thromboprophylaxis with Fondaparinux and Enoxaparin in Patients with COVID19 Infection in Italy

Giuseppe Vito Viggiano, Giuseppe Cardillo, Vincenzo Russo, Sara Mangiacapra, Antonella Cavalli, Chiara Pesci, Andrea Fontanella, Federica Agrusta, Annamaria Bellizzi, Maria Amitrano, Mariateresa Iannuzzo, Clara Sacco, Corrado Lodigiani, Pierpaolo Di Micco

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: covid19; sars cov2; fondaparinux; enoxaparin; venous thrpmbpembolism; inflammatory diseases

Online: 19 May 2020 (04:07:50 CEST)

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Background: After the outbreak of a novel coronavirus (i.e. SARS COV2) in China and its diffusion around the world, great attentions was reserved to the increased incidence of venous thromboembolism in these patients. A specific antiviral action of heparins toward SARS COV2 has been reported in vitro such as a well know action of heparins to prevent VTE in inpatients with infective disease has already been reported since several years. Yet, because fondaparinux represent the pharmacological antithrombotic active sequence of all heparins and because its clinical indication o prevent VTE in inpatients is similar to heprains, we realized a retrospective analysis in inpatients with SARS COV2 on the incidence of VTE during pharmacological prophylaxis with enoxaparin or fondaparinux. This retrospective analysis was named FONDENOXAVID. Methods: We conducted a retrospective cohort study that used patients with SARS COV2 during the Italian outbreak from February 18, 2020 to April 30, 2020. Our aim was to compare the clinical characteristics, prophylactic treatment and outcomes in inpatients positive to SARS COV2 at risk to develop venous thromboembolism, in particular venous thrombosis with or without pulmonary embolism, during in-hospital primary thromboprophylaxis with enoxaparin (40 mg or 60 mg once daily) or fondaparinux (2.5 mg once daily). Statistical analysis was conducted with using MatLab R2016B and eventually ad hoc functions. Results: There were not significative differences in clinical characteristics between patients that used enoxaparin or fondaparinux as thromboprpophylaxis for SARS COV2. The cumulative incidence of thrombotic events was not different in patients that used enoxaparin or fondaparinux as thromboprpophylaxis. No differences were found also in d-dimer and fibrinogen levels test at the admission and after 3 weeks as markers of prolonged inflammation due to SARS COV2. Discussion: The increased incidence of VTE in vivo has been reported in several studies although prophylaxis with low molecular weight heparin was conducted in some of them. The clinical indication to prevent VTE was similar for heparins and fondaparinux. In our results a non-inferiority to prevent VTE was recorded when inpatients with SARS COV2 were treated with prophylactic doses of enoxaparin or fondaparinux according to international guidelines. The incidence of VTE in this retrospective analysis showed that Fondaparinux at fixed doses of 2.5 mg daily was not inferior to enoxaparin (4000 UI daily). Our results testify that fondaparinux and enoxaparin showed the same efficacy to reduce the incidence of VTE in inpatients with SARS COV2.

Preprint ARTICLE | doi:10.20944/preprints202305.1062.v1

Symptoms-Based Clinical Algorithm for the Diagnosis and Treatment of Pelvic Congestion Syndrome

Frank A Cusimano, Nicole Ciuffo, Martyna Czarnik, Nicole Gentile, Adam Tonis, David A Greuner

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: Pelvic Congestion Syndrome; Pelvic Venous Insufficiency; Pelvic Pain; Contrast Venography; Venous Embolization; Stents; May-Thurner; Nutcracker; Pelvic Varicosities; Vulvar Varicosities; Pelvic Varicose Veins

Online: 15 May 2023 (16:07:08 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202308.2178.v1

Persistence Pays Off: Live Birth after Uterus Transplant, Over-coming Recurrent Pregnancy Loss with Cerclage Placement

Liza Johannesson, Sophie Anderson, J Michael Putman, Robert T Gunby, Lilly Zhang, Giuliano Testa, Anthony R Gregg

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: cerclage; cervical insufficiency; graft rejection; inflammation; uterus transplantation; venous outflow

Online: 31 August 2023 (12:10:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0980.v1

Cystathionine gamma lyase is regulated by flow and controls smooth muscle migration in human saphenous vein

Shuang Zhao, Céline Deslarzes-Dubuis, Severine Urfer, Martine Lambelet, Sébastien Déglise, Florent Allagnat

Subject: Biology And Life Sciences, Anatomy And Physiology Keywords: Hydrogen sulfide (H2S), Cystathionine gamma-Lyase, intimal hyperplasia, venous bypass

Online: 14 July 2023 (07:58:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1209.v1

Pancreatectomy With En Bloc Superior Mesenteric Vein And All Its Tributaries Resection Without PV/SMV Reconstruction For “Low” Locally Advanced Pancreatic Cancer

VIACHESLAV EGOROV, Pavel Kim, Soslan Dzigasov, Eugeny Kondratiev, Alexander Sorokin, Alexey Kolygin, Mikhail Vyborniy, Grigoriy Bolshakov, Pavel Popov, Anna Demchenkova, Tatiana Dakhtler

Subject: Medicine And Pharmacology, Surgery Keywords: locally advanced PDAC; vein resection without PV/SMV reconstruction; pancreatic cancer; portal venous collaterals; low pancreatic cancer; superior mesenteric vein occlusion; CT-based venous reconstructions

Online: 20 May 2024 (07:05:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1913.v1

Prevalence and Clinical Burden of Venous Thromboembolic Events (VTEs) in Contemporary Total Knee Arthroplasties (TKAs) in US Hospitals

Halil Ibrahim Bulut, Maria Jose Maestre, Daniel Tomey

Subject: Medicine And Pharmacology, Orthopedics And Sports Medicine Keywords: Total Knee Arthroplasty; Pulmonary embolism; Deep vein thrombosis; Venous Thromboembolic Events

Online: 29 April 2024 (12:30:24 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.2264.v1

Chronic Fatigue Syndrome and Multiple Sclerosis have Reduced Craniospinal Compliance and Dilated Pressurized Bridging Cortical Veins: A Hypothesis Illustrated with Two Case Studies

Grant Bateman, Alexander Bateman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Chronic fatigue syndrome; myalgic encephalomyelitis; multiple sclerosis; cortical vein; venous pressure

Online: 31 May 2023 (14:31:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0455.v1

Case Report: An Unusual Case of High-Risk Pulmonary Embolism in a Post-COVID 19 Female Under Hormonal Contraception

Andrea Sonaglioni, Michele Lombardo, Adriana Albini, Douglas M. Noonan, Gaetana Anna Rispoli, Gian Luigi Nicolosi, Daniele Mazzarella, Roberto Cassandro, Sergio Harari

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: COVID-19 Coagulopathy; hormonal contraception; COVID-19; venous thromboembolism; pulmonary embolism; thrombolysis

Online: 8 May 2023 (05:29:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0135.v1

Arterial and Venous Thrombosis in COVID-19 Disease: From Molecular Pathway to Vaccine Administration

Francesco Nappi, Adelaide Iervolino, Sanjeet Singh Avtaar Singh

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Arterial and Venous Thrombosis; COVID-19 disease; SARS-CoV-2 infection; vaccines

Online: 4 June 2021 (10:46:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1479.v1

Clinical Implications of Umbilical Venous Blood Flow to Placental Ratio in Fetal Well-Being

Xiu-Qin Wu, Lin Ye, Xiao-bin Zhang, Xiao-Feng Yang, Yong-Qiang Yong-Qiang Hong, Wei-Hsiu Chiu

Subject: Medicine And Pharmacology, Obstetrics And Gynaecology Keywords: placental insufficiency; umbilical venous blood flow; placental pulsatility index; Doppler ultrasound; prenatal care

Online: 23 April 2024 (09:13:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1113.v1

Myocardial Infarction, Deep Venous Thrombosis, and Pulmonary Embolism in SARs-CoV-2 Hospitalizations; Insights from the National Inpatient Sample 2020

Endurance Evbayekha, Ovie Okorare, Gabriel Alugba, Anthony Willie, Ede Omosumwen, Chinemerem Martlin Emeasoba, Bolanle Hawau Salaudeen, Anita Ogochukwu Onyekwere, Awanwosa Valentine Agho, Omolola Okunromade, Adeniyi Kayode Busari, Agatha Olawunmi Akinsete, Erhieyovbe Emore, Ibilola Akorede Sanusi, Agunwa Nnaemeka, Victor Ameh Odoma, Lovette Ugonma, Emeka Kenneth Okobi, Okelue E. Okobi

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: SARS‐CoV‐2; COVID‐19; Pulmonary embolism; PE; deep venous thrombosis; DVT; hospitalization

Online: 19 July 2023 (04:41:51 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202302.0509.v1

A Bridge to Nowhere: Enabling Autonomy in a Case of Failed ECMO Rescue of Bleomycin Induced Pulmonary Toxicity

James Hall, Michael Khilkin, Sara Murphy, George Botros

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: bleomycin; ECMO; pulmonary fibrosis; pulmonary toxicity; veno-venous extracorporeal membrane oxygenation; lung transplant

Online: 28 February 2023 (06:46:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202409.1306.v1

Influence of Patient Position-Related Differences in Intra- and Postoperative Implications on Major Anesthesia Parameters in Posterior Fossa Surgery

Oana Maria Radu, Georgeta Magdalena Balaci, Daniel Corneliu Leucuța, Vlad Ioan Moisescu, Cristina Munteanu, Stefan Ioan Florian

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: hemodynamic implications; venous air embolism; sitting position; park-bench position; EtCO2; pneumocephalus; postoperative hematoma

Online: 17 September 2024 (10:42:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1330.v1

Treatment of Superficial Vein Thrombosis: Recent Advances, Unmet Needs and Future Directions

Marcello Di Nisio, Giuseppe Camporese, Pierpaolo Di Micco, Romeo Martini, Walter Ageno, Paolo Prandoni

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: superficial vein thrombosis; low-molecular-weight heparin; fondaparinux; venous thromboembolism; anticoagulation; direct oral anticoagulants

Online: 20 June 2024 (10:15:47 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202404.1727.v1

Persistently High Platelet Factor 4 Levels in an Adolescent With Recurrent Late Thrombotic Complications After SARS-CoV-2 mRNA Vaccination

Yoichi Haga, Akira Ohara, Tsuneyoshi Yakuwa, Akari Yamashita, Midori Udo, Masaki Matsuoka, Hiroshi Ohara, Atsushi Yasumoto, Hiroyuki Takahashi

Subject: Medicine And Pharmacology, Hematology Keywords: ; platelet factor 4; SARS-CoV-2 vaccine; venous thrombosis; antiphospholipid syndrome; anticoagulants ;

Online: 28 April 2024 (07:30:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202402.0620.v1

Prognostic Significance of Heart Failure in Acute Pulmonary Embolism: A Comprehensive Assessment of 30-Day Outcomes

Mariam Farid-Zahran Osuna, Manuel Méndez-Bailón, José María Pedrajas, Rubén Alonso-Beato, Francisco Galeano-Valle, Vanesa Sendín Martín, Javier Marco-Martínez, Pablo Demelo-Rodríguez

Subject: Medicine And Pharmacology, Hematology Keywords: heart failure; venous thromboembolism; pulmonary embolism; mortality; bleeding; comorbidity; left ventricular ejection fraction (LVEF)

Online: 12 February 2024 (08:51:07 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202309.2109.v4

Long COVID: A Chronic Shortage of Blood. Treatment Proposal Based on Reasoned Speculation from Pathophysiological Principles

Pieter A. Molenaar

Subject: Medicine And Pharmacology, Internal Medicine Keywords: blood volume; allocation of blood flow; arteriolovenous anastomosis; venous blood buffer; vascular constriction; blood osmolality; haematocrit, albumin; haemodynamics

Online: 17 July 2024 (11:02:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.2230.v1

Primary LYmphedema Multidisciplinary Approach (P-LYMA) in Patients Affected by Primary Lower Extremity Lymphedema

Pedro Ciudad, Alberto Bolletta, Juste Kaciulyte, Oscar J. Manrique, Joseph M. Escandón

Subject: Medicine And Pharmacology, Surgery Keywords: Lymphedema; supermicrosurgery; suction-assisted lipectomy (SAL); lymphatico-venous anastomoses (LVA); vascularized lymph node transfer.

Online: 3 July 2023 (03:08:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0495.v1

Deep Learning Approaches to Automatic Chronic Venous Disease Classification

Marina Barulina, Aschat Sanbaev, Sergey Okunkov, Ivan Ulitin, Ivan Okoneshnikov

Subject: Computer Science And Mathematics, Artificial Intelligence And Machine Learning Keywords: chronic venous disease; deep leaning; data mining; Resnet50; DeiT; automatic classification; automatic CEAP classification

Online: 29 August 2022 (12:46:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2378.v1

Nurse-Driven Quality Improvement Interventions Reduced the Incidence of Central-Line-Associated Bloodstream Infection and Catheter-Related Bloodstream Infection to Close to Zero, a Turning Point in One Pediatric Oncologic Facility

Federico Turoldo, Antonella Longo, Mariavittoria Sala, Denis Valentini, Nicole De Vita, Sara Toniutti, Loredana Zuppel, Natalia Maximova

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: central venous catheter; pediatric; oncological; central-line– associated bloodstream infections; catheter-related bloodstream infections

Online: 30 July 2024 (07:34:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1715.v1

Percutaneous Deep Venous Arterialization for Limb Salvage of No Option Patients with Chronic Limb-Threatening Ischemia

Stavros Spiliopoulos, Efstathia Davoutis, Nikolaos-Achilleas Arkoudis, Kaji Sritharan, Symeon Lechareas

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: chronic limb-threatening ischemia; peripheral arterial disease; endovascular treatment; tibial vessels; percutaneous deep venous arterialization

Online: 26 September 2023 (04:44:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0230.v1

How the First Year of the COVID-19 Pandemic Impacted Patients’ Care in the Vascular Surgery Divisions of the Southern Regions of the Italian Peninsula

Eugenio Martelli, Giovanni Sotgiu, Laura Saderi, Massimo Federici, Giuseppe Sangiorgi, Matilde Zamboni, Allegra Rosa Martelli, Giancarlo Accarino, Giuseppe Bianco, Francesco Bonanno, Umberto Marcello Bracale, Enrico Cappello, Giovanni Cioffi, Giovanni Colacchio, Adolfo Crinisio, Salvatore De Vivo, Carlo Patrizio Dionisi, Loris Flora, Giovanni Impedovo, Francesco Intrieri, Luca Iorio, Gabriele Maritati, Piero Modugno, Mario Monaco, Giuseppe Natalicchio, Vincenzo Palazzo, Fernando Petrosino, Francesco Pompeo, Raffaele Pulli, Davide Razzano, Maurizio Ruggero Ruggieri, Carlo Ruotolo, Paolo Sangiuolo, Gennaro Vigliotti, Pietro Volpe, Antonella Biello, Pietro Boggia, Michelangelo Boschetti, Enrico Maria Centritto, Flavia Condò, Lucia Cucciolillo, Amodio Salvatore D'Amodio, Mario De Laurentis, Claudio Desantis, Daniela Di Lella, Giovanni Di Nardo, Angelo Disabato, Ilaria Ficarelli, Angelo Gasparre, Antonio Nicola Giordano, Alessandro Luongo, Mafalda Massara, Vincenzo Molinari, Andrea Padricelli, Marco Panagrosso, Anna Petrone, Serena Pisanello, Roberto Prunella, Michele Tedesco, Alberto Maria Settembrini

Subject: Medicine And Pharmacology, Hematology Keywords: COVID-19; carotid stenosis; abdominal aortic aneurysm; chronic limb-threatening ischemia; amputation; deep venous thrombosis

Online: 16 June 2022 (04:40:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0190.v1

Neurovascular Manifestations of Iron-Deficient Anemia: Narrative Review and Practical Reflections through A Teaching Case

Marialuisa Zedde, Giacomo Portaro, Laura Ferri, Francesco Cavallieri, Manuela Napoli, Claudio Moratti, Fabrizio Piazza, Franco Valzania, Rosario Pascarella

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: iron-deficient anemia; IDA; stroke; cerebral venous thrombosis; brain MRI; aortic thrombosis; pulmonary embolism; embolic pattern

Online: 10 August 2022 (04:31:26 CEST)

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Background: Anemia is one of the most frequent diseases worldwide, affecting a third of the general population. Anemia in general and in particular, iron-deficient anemia (IDA), has been associated to a higher risk of thrombotic manifestations, including ischemic stroke and cerebral venous thrombosis (CVT), as well as systemic extra cerebral arterial and venous thrombosis. Despite these data, anemia is seldom considered as an etiological factor of stroke. Methods: An individual case encompassing all known neurovascular and systemic arterial and venous thrombotic manifestations related to IDA is presented with the focus on clinical reasoning issues in the diagnostic pathways, starting from the neuroradiological signs. The main questions have been identified and addressed in a narrative review of the most relevant data in the literature from a pragmatic and clinical viewpoint. Results and Discussion: The presented case concerns a 46 years old man admitted to the Stroke Unit because of acute is-chemic stroke with multiple thrombi in large intracranial and extracranial vessels, multifocal ischemic lesions in several arterial territories and the concurrent finding of asymptomatic CVT, pulmonary embolism with lung infarction and aortic thrombosis. An extended diagnostic work-up excluded the main etiologies (arterial dissection, cardiac embolism, genetic and acquired prothrombotic disorders, as cancer and antiphospholipid syndrome), except for a severe IDA, such as to require blood transfusions followed by anticoagulant therapy for the several thrombotic manifestations. Neuroimaging and systemic vascular findings have been analyzed and the main issues proposed by the case in the diagnostic pathway have been identified and discussed in a pragmatic clinical road map reviewing the data provided by the literature. Conclusions: IDA is a common but treatable condition that, independently or synergically, may increase the risk of thrombotic events. The diagnostic and therapeutic approach has not yet defined and each case should be individually addressed in a pragmatic clinical road map.

Preprint ARTICLE | doi:10.20944/preprints202410.0971.v1

Characterizing Bloodstream Infections in Chronic Hemodialysis Patients: A Single Center Experience

Mohan Bilikallahalli Sannathimmappa, Rajeev Aravindakshan, Vinod Nambiar, Walaa Abdelmoeiz Ahmed, Layan Salim Al Mazroey, Amjad Mohammed Al-Gazali, Alrayan Hamood Alhooti, Arwa Basim Alhasani, Hind Yousuf Abdullah Al Blushi, Elham Said Ahmed AL Risi, Salima Al Maqbali

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: C-reactive protein; End organ dysfunction; Hemodialysis; Lactate; Sepsis; Central Venous Catheter; Hemodialysis; Multidrug Resistance; Sepsis; Staphylococcus

Online: 15 October 2024 (03:33:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.0740.v1

NLP-Driven Analysis of Pneumothorax Incidence Following Central Venous Catheter Procedures: A Data-Driven Reevaluation of Routine Imaging in Value-Based Medicine

Martin EM Breitwieser, Vanessa Moore, Teresa Wiesner, Florian Wichlas, Christian Deininger

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: pneumothorax; CVC; central venous catheterization; removal; NLP; natural language processing; machine learning; value-based medicine; cost-effectiveness

Online: 10 October 2024 (10:27:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1875.v1

Quality of Life in Patients With Venous Leg Ulcers Treated by Means of Local Hyperbaric Oxygen Therapy or Local Ozone Therapy – A Single Center Study

Jarosław Pasek, Sebastian Szajkowski, Grzegorz Cieślar

Subject: Public Health And Healthcare, Public Health And Health Services Keywords: quality of life; ozone therapy; local hyperbaric oxygen therapy; venous leg ulcers; treatment; hard to heal wounds

Online: 30 October 2023 (09:08:39 CET)

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Venous leg ulcers still pose a significant medical problem worldwide. The complexity of the problem determines the need for further interdisciplinary activities that will improve the quality of life of treated patients. The study compared the quality of life of patients with venous leg ulcers who received local hyperbaric oxygen therapy or local ozone therapy procedures as a part of comprehensive treatment. The study included 129 patients (62 men and 57 women) with venous leg ulcers. Group I underwent local hyperbaric oxygen therapy (HBOT), group II - local ozone therapy (OZONE). In both groups, the patients' quality of life was assessed before the start of treatment cycle, as well as 10 weeks and 6 months after the completion of the treatment, by using the EQ-5D-5L questionnaire and the Polish shortened version of the SF-36 scale. After completing the respective therapeutic cycle, both groups showed a statistically significant (p<0.001) improvement the quality of life according to the EQ-5D-5L questionnaire and the SF-36 scale. Differences were noted between 1st examination (before treatment) and 2nd examination (10 weeks after treatment), as well as 3 examination (6 months after treatment). In the EQ-5D-5L assessment of anxiety and depression, self-care and activities of daily living 6 months after the end of treatment, better results were found in the group of patients treated with local hyperbaric oxygen therapy (p<0.001). In this group, 6 months after the end of the treatment, a statistically significantly higher result on the EQ-VAS scale was also obtained (73.09±19.8 points vs. 68.03±17.37 points, p=0.043). However, in the SF-36 assessment 6 months after the end of treatment better results - a statistically significantly lower value of the quality of life index - were recorded in the group of patients treated with local ozone therapy (103.13±15.76 points vs. 109.89±15.42 points, p<0.015). Hyperbaric oxygen therapy and local ozone therapy procedures have a beneficial effect on improving the quality of life of patients with venous leg ulcers.

Preprint ARTICLE | doi:10.20944/preprints202401.0013.v1

Physiology of Deep Closed-Circuit Rebreather (CCR) Mixed Gas Diving: Gas Emboli, Spirometry and Biological Changes during a Week-Long Liveaboard Safari

Costantino Balestra, Clément Leveque, Simona Mrackic-Sposta, Alessandra Vezzoli, Pierre Wauthy, Peter Germonpré, Frauke Tillmans, François Guerrero, Pierre Lafère

Subject: Medicine And Pharmacology, Other Keywords: Decompression physiology; Venous gas emboli (VGE); Human; Reactive oxygen species (ROS); Oxidative stress; Inflammation; DCS; Hormesis; Acute Phase Reactants

Online: 3 January 2024 (03:17:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0758.v1

Comparative Clinical Performances of Tunneled Central Venous Catheter Versus Arterio-Venous Accesses in Patients Receiving High Volume Hemodiafiltration: The Case for High-Flow DualCath, a Tunneled Two Single Lumen Silicone Catheter

Bernard Canaud, Hélène Leray-Moragues, Leila Chenine, Marion Morena-Carrere, George Miller, Ludovic Canaud, Jean-Paul Cristol

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: Vascular access; Tunneled central venous catheter; Dialysis clinical performances; Diffusive dialysis dose; Convective dialysis dose; Effective blood flow; Recirculation

Online: 12 June 2023 (04:46:26 CEST)

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Tunneled central venous catheters (CVC) are mainly considered as rescue vascular access option in dialysis but still used in about one quarter of prevalent patients worldwide as being associated with poor performances and higher risks. Study design. In this retrospective single-center study, we aimed to report on clinical performances achieved with high-flow tunneled CVC (DualCath, DCath) and compared it with arteriovenous accesses (AVAs; AV fistula, AV graft, Thomas Shunt) in a hospital-based dialysis unit. Methods. Sixty-eight stage 5 chronic kidney disease dialysis dependent patients (CKD5D) receiving high volume hemodiafiltration were followed-up for 30 months. The study consisted of two phases: baseline cross-sectional and longitudinal follow-up of key performance indicators. Clinical performances consisting of effective blood flow and blood volume, recirculation, urea and ionic Kt/V and total Kt, ultrafiltration volume and percent reduction of ß2-M were measured monthly as part of quality control in our unit. Results. At baseline, effective blood flow with DCath was close to 400 ml/min, similar to AVAs. Recirculation with DCath (7%, 6-13%) was higher than AVAs. Diffusive dialysis dose delivered with DCath (spKt and eKt/V) and convective dialysis dose achieved with DCath were slightly lower than AVAs, but still much higher than recommended by guidelines. Percent reduction of ß2-M achieved with DCath was also 4 to 10% lower than AVAs. On longitudinal follow-up, main clinical performance indicators of DCath (total Kt and total ultrafiltration volume, L/session) were maintained very stable over time and close to those achieved with AVAs. Conclusions. As shown in this study, high-flow DualCath tunneled two single lumen silicone catheters may be used to deliver high volume hemodiafiltration in a reliable and consistent manner without compromising clinical performances. These results rely from the specific design of the two silicone cannulas and the strict adherence to best catheter practices.

Preprint ARTICLE | doi:10.20944/preprints202305.2005.v1

Implementation of a Vascular Access Specialist Team in a Tertiary Hospital: A Cost-Benefit Analysis

Laura Ricou Ríos, Candela Esposito Català, Arnau Pons Calsapeu, Cristina Adroher Mas, Isabel Andrés Martínez, Isaac Nuño Ruiz, Mònica Castellà Creus, Laia Castellà Fàbregas, Maria José García Quesada, Oriol Estrada Cuxart, Jordi Ara del Rey, Francesc López Seguó

Subject: Public Health And Healthcare, Nursing Keywords: Catheters; Cost Benefit Analysis; Economic evaluation; Healthcare-associated infections; Nursing care; Peripherally Inserted Central Catheter; Peripheral Venous Catheters; Ultrasound.

Online: 29 May 2023 (09:58:33 CEST)

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Background: The use of peripherally inserted central catheters and midline catheters is growing due to their potential benefits. These devices can increase patient safety and satisfaction while reducing the use of resources. As a result, many hospitals are establishing vascular access specialist teams staffed by nurses who are trained in the insertion and maintenance of these catheters. Objective: Evaluate ex-ante whether the benefits of replacing peripheral venous catheters, peripherally inserted central catheters and midline catheters with ultrasound-guided peripherally inserted central catheters and midline catheters by a vascular access specialist team outweigh their costs. Methods: Cost-benefit analysis from the perspective of the healthcare provider based on administrative data. The study estimates the reduction in resources used when replacing peripherally inserted central catheters, midline catheters and peripheral venous catheters with ultrasound-guided peripherally inserted central catheters and midlines, as well as the additional resources required for their use. Results: Each ultrasound-guided peripherally inserted central catheter replacing a peripherally inserted central catheter, results in a measurable resource reduction of approximately €31. When 3 peripheral venous catheters are replaced by an ultrasound-guided peripherally inserted central catheter, the saving is €63. Similarly, each ultrasound-guided midline catheter replacing a midline, results in a reduction of €16, while each ultrasound-guided midline catheter replacing 3 peripheral venous catheters results in a reduction of €96. Conclusion: The benefits of replacing peripheral venous catheters, peripherally inserted central catheters and midline catheters by introducing a vascular access specialist team trained in the implantation of ultrasound-guided peripherally inserted central catheters and midline catheters, outweigh its cost mainly because of the decrease in hospital stay due to the lowered risk of healthcare-associated infections. These results motivate the implementation of the service, adding to previous experience suggesting that it is also preferable from the point of view of patient safety and satisfaction.

Preprint ARTICLE | doi:10.20944/preprints202310.1464.v1

Effect of Pharmacoprophylaxis on Postoperative Outcomes in Adult Elective Colorectal Surgery: A Multi-Center Retrospective Cohort Study within an Enhanced Recovery after Surgery Framework

William Olin Blair, Mary Allison Ellis, Maria Fada, Austin Allen Wiggins, Rachel Stratmen Wolfe, Gourang P Patel, Kara K Brockhaus, Molly Droege, Laura M Ebbitt, Brian Kramer, Eric Likar, Kerilyn Petrucci, Sapna Shah, Jerusha Taylor, Paula Bignham, Samuel Krabacher, Jin Hyung Moon, Monica Rogoz, Edson Jdean-Jacques, Robdert K Cleary, Ransome Eke, Rachelle Findley, Richard H Parrish II, Enhanced Recovery Comparative Pharmacotherapy Collaborative

Subject: Medicine And Pharmacology, Pharmacy Keywords: enhanced recovery; ileus; outcomes, postoperative; pain, postoperative; pharmacotherapy; postoperative nausea and vomiting; prophylaxis; surgical site infection; surgery, colorectal; venous thromboembolism

Online: 23 October 2023 (15:34:14 CEST)

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Working Paper ARTICLE

Cytomegalovirus-Associated Venous and Arterial Thrombotic Disease

Amar Kelkar, Brian Loc, Michael Tarantino, Anita Rajasekhar, Huaping Wang, Mona Kelkar, John Farrell

Subject: Medicine And Pharmacology, Immunology And Allergy Keywords: Acquired Coagulation Disorders; Arterial thrombosis; prophylaxis; diagnosis; and treatment; Infections in immunocompromised hosts; Viral Infection; Venous thromboembolism; prophylaxis; diagnosis; treatment

Online: 16 October 2020 (12:09:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202410.1178.v1

Combining Erection Restoration and Factual Penile Enhancement Based on Revolutionary Penile Fibro-vascular Assembly

Cho-Hsing Chung, Ko-Shih Chang, Heng-Shuen Chen, Yi-Ying Hsieh, Yu-Hsiang Chang, Geng-Long Hsu, Mang-Hung Tsai, Jeff SC Chueh

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: factual penile enhancement; penile fibro-vascular assembly; penile venous stripping; veno-occlusive dysfunction; erection-related veins; deep dorsal vein; cavernosal vein

Online: 15 October 2024 (11:18:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1377.v1

Emergent Combining Factual Penile Girth Enhancement and Erection Restoration Based on Revolutionary Penile Fibro-vascular Assembly

Ko-Shih Chang, Cho-Hsing Chung, Yi-Kai Chang, Geng-Long Hsu, Mang-Hung Tsai, Jeff SC Chueh

Subject: Medicine And Pharmacology, Clinical Medicine Keywords: factual penile enhancement; penile fibro-vascular assembly; penile venous stripping; veno-occlusive dysfunction; erection-related veins; deep dorsal vein; cavernosal vein

Online: 20 June 2024 (15:40:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0166.v1

Mediators of Regional Kidney Perfusion during Surgical Pneumoperitoneum Creation and the Risk of Acute Kidney Injury – A Review of Basic Physiology

Csaba Kopitkó, László Medve, Tibor Gondos, Karim Magdy Mohamed Soliman, Tibor Fülöp

Subject: Medicine And Pharmacology, Urology And Nephrology Keywords: acute kidney injury; intra-abdominal pressure; oxidative stress; renal cortical blood flow; renal medullar blood flow; renal lymphatic drainage; venous congestion

Online: 18 April 2022 (10:45:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202301.0010.v1

Usefulness of Systemic Venous Ultrasound Protocols in the Prognosis of Heart Failure Patients: Results from a Prospective Multicentric Study

Marta Torres-Arrese, Arantzazu Mata-Martínez, Davide Luordo-Tedesco, Gonzalo García-Casasola, Rodrigo Alonso-González, Esther Montero-Hernández, Marta Cobo-Marcos, Beatriz Sánchez-Sauce, Valentín Cuervas-mons, Yale Tung-Chen

Subject: Medicine And Pharmacology, Cardiac And Cardiovascular Systems Keywords: point-of-care ultrasound; Doppler ultrasound; VExUS; venous excess ultrasonography; acute heart failure; portal vein; hepatic vein; intrarenal vein; inferior vena cava

Online: 3 January 2023 (07:33:46 CET)

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