Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Clinical Significance of Early Venous Filling Detected via Preoperative Angiography in Glioblastoma

Kotaro Tatebayashi
,
Noriyuki Nakayama
,
Daisuke Sakamoto
ORCID logo ,
Tomoko Iida
,
Shun Ono
,
Ikuo Matsuda
,
Yukiko Enomoto
,
Michihiro Tanaka
,
Mitsugu Fujita
ORCID logo ,
Seiichi Hirota
,
Shinichi Yoshimura
* ORCID logo
Version 1 : Received: 28 June 2023 / Approved: 3 July 2023 / Online: 3 July 2023 (12:47:58 CEST)

A peer-reviewed article of this Preprint also exists.

Tatebayashi, K.; Nakayama, N.; Sakamoto, D.; Iida, T.; Ono, S.; Matsuda, I.; Enomoto, Y.; Tanaka, M.; Fujita, M.; Hirota, S.; Yoshimura, S. Clinical Significance of Early Venous Filling Detected via Preoperative Angiography in Glioblastoma. Cancers 2023, 15, 3800. Tatebayashi, K.; Nakayama, N.; Sakamoto, D.; Iida, T.; Ono, S.; Matsuda, I.; Enomoto, Y.; Tanaka, M.; Fujita, M.; Hirota, S.; Yoshimura, S. Clinical Significance of Early Venous Filling Detected via Preoperative Angiography in Glioblastoma. Cancers 2023, 15, 3800.

Abstract

Preoperative angiography in glioblastoma (GBM) often shows arteriovenous shunts and early venous filling (EVF). Here, we investigated the clinical implications of EVF in GBM as a prognostic and vascular mimicry biomarker. In this retrospective multicenter study, we consecutively enrolled patients who underwent angiography with a GBM diagnosis between April 1, 2013, and March 31, 2021. The primary and secondary endpoints were the differences in overall survival (OS) and progression-free survival (PFS), respectively, between cases with and without EVF. Of 133 initially enrolled patients, 91 newly diagnosed with GBM underwent preoperative angi-ography and became the study population. The 6-year OS and PFS were significantly worse in the EVF than in the non-EVF group. Moreover, 20 GBM cases (10 with EVF and 10 without EVF) were randomly selected and evaluated for histological vascular mimicry. Except for two cases that were difficult to evaluate, the EVF group had a significantly higher frequency of vascular mimicry than the non-EVF group (0/8 vs. 5/10, P = 0.04). EVF on preoperative angiography is a robust prognostic biomarker for GBM and may help detect cases with a high frequency of histological vascular mimicry.

Keywords

glioblastoma; early venous filling; arteriovenous shunt; vascular mimicry; Avastin

Subject

Medicine and Pharmacology, Neuroscience and Neurology

Copyright: This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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