Preprint Article Version 1 Preserved in Portico This version is not peer-reviewed

Case Report: An Unusual Case of High-Risk Pulmonary Embolism in a Post-COVID 19 Female Under Hormonal Contraception

Version 1 : Received: 6 May 2023 / Approved: 8 May 2023 / Online: 8 May 2023 (05:29:27 CEST)

How to cite: Sonaglioni, A.; Lombardo, M.; Albini, A.; Noonan, D.M.; Rispoli, G.A.; Nicolosi, G.L.; Mazzarella, D.; Cassandro, R.; Harari, S. Case Report: An Unusual Case of High-Risk Pulmonary Embolism in a Post-COVID 19 Female Under Hormonal Contraception. Preprints 2023, 2023050455. https://doi.org/10.20944/preprints202305.0455.v1 Sonaglioni, A.; Lombardo, M.; Albini, A.; Noonan, D.M.; Rispoli, G.A.; Nicolosi, G.L.; Mazzarella, D.; Cassandro, R.; Harari, S. Case Report: An Unusual Case of High-Risk Pulmonary Embolism in a Post-COVID 19 Female Under Hormonal Contraception. Preprints 2023, 2023050455. https://doi.org/10.20944/preprints202305.0455.v1

Abstract

Coronavirus 19 disease (COVID-19) may be complicated by thrombotic events, particularly venous thromboembolism (VTE), which have been reported both in critically ill hospitalized patients and in individuals with mild symptoms. It is known that the chronic use of oral contraceptive pills (OCPs) is associated with higher risk of VTE. To date, there are only few reports concerning the association of OCPs and VTE/pulmonary embolism (PE) in COVID-19 patients. Given that during the convalescent phase of disease, a state of endothelial dysfunction, hypercoagulability and a low-grade inflammation may be persistent, the occurrence of thromboembolic events following acute COVID-19 infection may be not surprising. Herein, we report a case of high-risk PE detected in a post-COVID-19 young woman under hormonal contraception, which required thrombolytic treatment. A number of prothrombotic phenomena, such as overweight, hormonal contraceptive therapy, recent COVID-19 infection and prolonged immobilization, might have synergically contributed to the development of a sublethal thromboembolic event.

Keywords

COVID-19 Coagulopathy; hormonal contraception; COVID-19; venous thromboembolism; pulmonary embolism; thrombolysis

Subject

Medicine and Pharmacology, Clinical Medicine

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