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Dynamics Parameter Calibration for Performance Enhancement of Heavy-Duty Servo Press
Jian Li
,Shuaiyi Ma
,Bingqing Liu
,Tao Liu
,Zhen Wang
Posted: 12 December 2025
Derivation of Hubble’s Law: Unified Field-Theoretic Explanations for Dark Energy, Dark Matter and Huge Magnetic Toroids of the Galaxy
Haiqiang Wu
Posted: 12 December 2025
OpenADMET: Embracing the Avoid-Ome to Transform Drug Discovery
James S. Fraser
,Steven Edgar
,L. Naomi Handly
,Sriram Kosuri
,John D. Chodera
,Mark Murcko
,W. Patrick Walters
Posted: 12 December 2025
Reassessed Ability of Carbon-Based Physisorbing Materials to Keep Pace with Evolving Practical Targets for Hydrogen Storage
Patrick Langlois
,Chavdar Chilev
,Farida Lamari
Posted: 12 December 2025
Psychoactive Substance Use and Violent Death: Toxicological and Geospatial Evidence from a Four-Region Cross-Sectional Study in Brazil
Henrique Silva Bombana
,Vanderlei Carneiro da Silva
,Ivan Dieb Miziara
,Heráclito Barbosa Carvalho
,Mauricio Yonamine
,Vilma Leyton
Posted: 12 December 2025
The Geometry and Flow of Informational Time
Florian Neukart
Posted: 12 December 2025
An Integrated Cyber-Physical Digital Twin Architecture with QFT Robust Control for NIS2-Aligned Industrial Robotics
Vesela Angelova Karlova-Sergieva
,Boris Simon Grasiani
,Nina Georgieva Nikolova
The article presents an integrated framework for robust control and cybersecurity of an industrial robot, combining Quantitative Feedback Theory (QFT), Digital Twin (DT) technology, and PLC-based architecture aligned with the requirements of the NIS2 Directive. The proposed concept, denoted as Cyber-Physical Digital Twin with QFT & NIS2 Security (CPDTQN), unifies control, observability, synchronization, and traceability mechanisms within a single cyber-physical structure. The study employs the five-axis industrial manipulator FANUC M-430iA/4FH, modeled as a set of SISO servo-axis channels subject to parametric uncertainty and external disturbances. For each axis, QFT controllers and prefilters are synthesized, and the system performance is evaluated using joint-space and TCP-space metrics, including maximum error, RMS error, and 3D positional deviation. A CPDTQN architecture is proposed in which the QFT controllers are executed in MATLAB, a Siemens PLC (CPU 1215C, FW v4.5) provides deterministic communication via Modbus TCP, OPC UA, and NTP/PTP synchronization, and the digital twin implemented in FANUC ROBOGUIDE reproduces the robot’s kinematics and dynamics in real time. This represents one of the first architectures that simultaneously integrates QFT control, real PLC-in-the-loop execution, a synchronized digital twin, and NIS2-oriented mechanisms for observability and traceability. Simulation results using nominal and worst-case dynamic models, as well as scenarios with externally applied torque disturbances, demonstrate that the system maintains robustness and tracking accuracy within the prescribed performance criteria. Furthermore, the study analyzes how the proposed CPDTQN architecture supports key NIS2 principles, including command traceability, disturbance resilience, access control, and mechanisms for forensic reconstruction in robotic manufacturing systems.
The article presents an integrated framework for robust control and cybersecurity of an industrial robot, combining Quantitative Feedback Theory (QFT), Digital Twin (DT) technology, and PLC-based architecture aligned with the requirements of the NIS2 Directive. The proposed concept, denoted as Cyber-Physical Digital Twin with QFT & NIS2 Security (CPDTQN), unifies control, observability, synchronization, and traceability mechanisms within a single cyber-physical structure. The study employs the five-axis industrial manipulator FANUC M-430iA/4FH, modeled as a set of SISO servo-axis channels subject to parametric uncertainty and external disturbances. For each axis, QFT controllers and prefilters are synthesized, and the system performance is evaluated using joint-space and TCP-space metrics, including maximum error, RMS error, and 3D positional deviation. A CPDTQN architecture is proposed in which the QFT controllers are executed in MATLAB, a Siemens PLC (CPU 1215C, FW v4.5) provides deterministic communication via Modbus TCP, OPC UA, and NTP/PTP synchronization, and the digital twin implemented in FANUC ROBOGUIDE reproduces the robot’s kinematics and dynamics in real time. This represents one of the first architectures that simultaneously integrates QFT control, real PLC-in-the-loop execution, a synchronized digital twin, and NIS2-oriented mechanisms for observability and traceability. Simulation results using nominal and worst-case dynamic models, as well as scenarios with externally applied torque disturbances, demonstrate that the system maintains robustness and tracking accuracy within the prescribed performance criteria. Furthermore, the study analyzes how the proposed CPDTQN architecture supports key NIS2 principles, including command traceability, disturbance resilience, access control, and mechanisms for forensic reconstruction in robotic manufacturing systems.
Posted: 12 December 2025
Transcription-Coupled Repair as a Mutagenic Mechanism During Replication Stress
Evelyn Zambrano
,Cristopher Fierro
,Fernanda Morales
,Marcia Manterola
,Ricardo Armisen
,Katherine Marcelain
Posted: 12 December 2025
Metallic Flexible NiTi Wire Microcrack Transducer for Label-Free Impedimetric Sensing of E. coli
Gizem Özlü Türk
,Mehmet Çağrı Soylu
Posted: 12 December 2025
Novel Intranasal Replication-Deficient NS1ΔC Flu Vaccine Confers Protection from Divergent Influenza A and B Viruses in Mice
Daria Shamakova
,Marina A. Shuklina
,Nikita Yolshin
,Ekaterina Romanovskaya-Romanko
,Anna-Polina Shurygina
,Kira Kudrya
,Arman Muzhikyan
,Mariia V. Sergeeva
,Marina Stukova
Posted: 12 December 2025
Antimicrobial Activity, Antibiotic Susceptibility, and Growth Kinetics of Lactic Acid Bacteria and Yeasts Isolated from Selected Ugandan Cheese Varieties
Andrew Mwebesa Muhame
,Ediriisa Mugampoza
,Paul Alex Wacoo
,Gernot Zarfel
,Clemens Kittinger
Posted: 12 December 2025
Phage PM16 Therapy Induce Long-Term Protective Immunity Against Proteus mirabilis via Macrophage Priming
Lina Al Allaf
,Anton V. Chechushkov
,Vera V. Morozova
,Yulia N. Kozlova
,Tatiana A. Ushakova
,Nina V. Tikunova
Bacteriophages, traditionally viewed solely as antibacterial agents, are increasingly being studied for their immunomodulatory properties. In this study, we demonstrate that PM16 phage therapy not only effectively controls subcutaneous Proteus mirabilis infection in mice, but also induces long-term specific humoral immunity against subsequent reinfection. This immunomodulatory effect was dose-dependent. In vitro, PM16 directly activates macrophages, leading to increased production of proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β) and inducible nitric oxide synthase, and enhances macrophage bactericidal activity against P. mirabilis. We assume that the enhancement of the adaptive immune response is mediated not by the phage acting as a classical antigenic adjuvant, but by its ability to prime innate immune cells, specifically macrophages. This priming leads to more efficient bacterial clearance, antigen presentation, and the formation of protective immunological memory.
Bacteriophages, traditionally viewed solely as antibacterial agents, are increasingly being studied for their immunomodulatory properties. In this study, we demonstrate that PM16 phage therapy not only effectively controls subcutaneous Proteus mirabilis infection in mice, but also induces long-term specific humoral immunity against subsequent reinfection. This immunomodulatory effect was dose-dependent. In vitro, PM16 directly activates macrophages, leading to increased production of proinflammatory cytokines (tumor necrosis factor-α and interleukin-1β) and inducible nitric oxide synthase, and enhances macrophage bactericidal activity against P. mirabilis. We assume that the enhancement of the adaptive immune response is mediated not by the phage acting as a classical antigenic adjuvant, but by its ability to prime innate immune cells, specifically macrophages. This priming leads to more efficient bacterial clearance, antigen presentation, and the formation of protective immunological memory.
Posted: 12 December 2025
Role of Morphological and Phenological Traits in Passive Resistance to Fusarium Head Blight in Wheat
Shayan Syed
,Žilvinas Liatukas
,Andrii Gorash
Posted: 12 December 2025
NP-Hardness Collapsed: Deterministic Resolution of Spin-Glass Ground States via Information-Geometric Manifolds (Scaling from N=8 to N=100)
Stefan Trauth
Posted: 12 December 2025
Dancing with the Algorithm: Gen Z’s Social Media Practices on TikTok and Instagram and Their Influence on Music Festival Experiences
Anđelina Marić Stanković
,Jovana Vuletić
,Milan Miletić
,Marija Bratić
,Ninoslav Golubović
This study examines how Generation Z’s digital practices on TikTok and Instagram shape their music festival experiences, focusing on event perception, engagement, and the development of collective identity. The aim is to identify key factors connecting online and offline aspects of festival participation. The research adopts a quantitative approach based on an online survey of 248 respondents born between 1995 and 2010 from various regions of Serbia. Data were analysed in SPSS 26.0 using Spearman correlation, quantile regression, and the Mann–Whitney test. Findings show that frequent social media use has a positive but limited effect on how important these platforms are perceived for the festival experience. However, user-generated content created by attendees plays a more significant role in shaping engagement and attitudes than influencer content. Influencer credibility also influences how festivals are interpreted digitally. The interplay between online interaction and offline participation motivates content sharing and reinforces a sense of community. Overall, the study concludes that social media and digital narratives are central to Generation Z’s festival experience. Authentic, attendee-created content strongly contributes to collective identity, helping bridge digital and physical dimensions – insights valuable for festival organisers, influencers, and cultural tourism.
This study examines how Generation Z’s digital practices on TikTok and Instagram shape their music festival experiences, focusing on event perception, engagement, and the development of collective identity. The aim is to identify key factors connecting online and offline aspects of festival participation. The research adopts a quantitative approach based on an online survey of 248 respondents born between 1995 and 2010 from various regions of Serbia. Data were analysed in SPSS 26.0 using Spearman correlation, quantile regression, and the Mann–Whitney test. Findings show that frequent social media use has a positive but limited effect on how important these platforms are perceived for the festival experience. However, user-generated content created by attendees plays a more significant role in shaping engagement and attitudes than influencer content. Influencer credibility also influences how festivals are interpreted digitally. The interplay between online interaction and offline participation motivates content sharing and reinforces a sense of community. Overall, the study concludes that social media and digital narratives are central to Generation Z’s festival experience. Authentic, attendee-created content strongly contributes to collective identity, helping bridge digital and physical dimensions – insights valuable for festival organisers, influencers, and cultural tourism.
Posted: 12 December 2025
The Discourse and Logic of the Concretisation Turn: A Critical Assessment of Professor Min Chao's Article 'Marx's Study of the French Revolution of 1848 and the Concretisation Turn in the Materialist Conception of History
Wei Meng
Posted: 12 December 2025
Student Mental Health Nurses’ Perceptions of Psychological Trauma Education and Its Impact on Their Practice, a Qualitative Study
Gwenne Louise McIntosh
,Margaret M Conlon
,Edel McGlanaghy
,Freya Collier-Sewell
Posted: 12 December 2025
Delivering Blue Economy and Nature Recovery in Coastal Communities – A Diverse Economies Perspective
Alex Midlen
Posted: 12 December 2025
The Implementation of Local Professionalism: Integrating De Javasche Bank Assets in Surabaya Post-Nationalization (1951–1953)
Clarisa Khairunisa
,Mutiara Zahira
,Khansa Ashilla Kaenuputri
,Firman Malik
,Ikhlasul Akmal Aditya
,Bintang Maheswara Al Fattah
,Hafna Ilmy Muhalla
,Nisya Aningrum
,Kemal Athallah Putra Jen
Posted: 12 December 2025
Evaluation of the CHIRPS Database in Association with Major Hurricanes in Mexico
José P. Vega-Camarena
,Luis Brito-Castillo
,Luis M. Farfán
,David Avalos-Cueva
,Emilio Palacios-Hernández
,Cesar O. Monzón
Posted: 12 December 2025
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