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Molecular Strategies of Carbohydrates Binding to Intrinsically Disordered Regions in Bacterial Transcription Factors
Yuri A. Purtov,
Olga N. Ozoline
Posted: 18 November 2025
Evolution of Insect Pollination Before Angiosperms and Lessons for Modern Ecosystems
Ilaria Negri,
Mario E. Toledo
Posted: 18 November 2025
Reactive Oxygen Species Drive Cell Migration and PD-L1 Expression via YB-1 Phosphorylation in Pleural Mesothelioma
Muhammad Hashim,
Gerald Timelthaler,
Dominik Kirchhofer,
Beatrice Kudlacek,
Berta Mosleh,
Katharina Sinn,
Ezzat Mohamed Awad,
Alireza Mir Hoda,
Bettina Grasl Kraupp,
Balazs Dome
+4 authors
Posted: 18 November 2025
Interaction Between the Gut Microbiome, Genetic and Clinical Risk Factors for Metabolic Dysfunction‐Associated Steatotic Liver Disease (MASLD) in Patients with Type 2 Diabetes Mellitus from Different Geographical Regions of Argentina
Bárbara Suarez,
Adriana Mabel Álvarez,
María Florencia Mascardi,
Ana Laura Manzano Ramos,
Dong Hoon Woo,
María Mercedes Gutiérrez,
Guillermo Alzueta,
María del Carmen Basbus,
Santiago Bruzone,
Patricia Cuart
+10 authors
Background: Local specific biomarkers for MASLD risk stratification are urgently needed in Argentina. Aim: To characterized the interaction of gut microbiome signatures, genetic and clinical risk factors for MASLD in diabetics from different regions of Argentina. Material Methods: We recruited 214 diabetics from different regions. Anthropometric, clinical, and lifestyle data were obtained from all participants, who also underwent abdominal ultrasound for MASLD diagnosis and oral swabbing. PNPLA3 gene was amplified by PCR from the swabs, and rs738409 genotype was determined by bidirectional sequencing. To profile the MASLD-associated microbiome, stool was collected from 170 participants. V4 16S rRNA gene sequencing was performed and reads were analysed using QIIME2 2024.10.1. R Studio 2022.12.0 was used for statistical analyses. Results: MASLD prevalence was 77.9%, with similar rates in all regions. FIB-4 scores <1.3 and >2.67 were detected in 55.3% and 7.4% of patients, respectively. Half of diabetics had PNPLA3-GG genotype, with the highest rates in Northwestern Argentina (64.9%; p=0.02 vs Buenos Aires). PNPLA3-GG genotype was an independent risk factor for FIB-4 score (p=0.0008), and a protective factor against HbA1c (p=0.004), fasting plasma glucose (p=0.008), and cholesterol levels (p=0.02). Marked regional differences were observed in microbiota diversity and composition in Argentina. After adjusting for geographical region, Negativibacillus genus was exclusively detected in diabetics with MASLD and GG carriers. Catenibacterium genus was related to FIB-4>2.67. Short-chain fatty acids-producing bacteria were linked to absence of MASLD. Conclusions: These specific signatures could be potentially useful as MASLD biomarkers for risk stratification in diabetics from Argentina.
Background: Local specific biomarkers for MASLD risk stratification are urgently needed in Argentina. Aim: To characterized the interaction of gut microbiome signatures, genetic and clinical risk factors for MASLD in diabetics from different regions of Argentina. Material Methods: We recruited 214 diabetics from different regions. Anthropometric, clinical, and lifestyle data were obtained from all participants, who also underwent abdominal ultrasound for MASLD diagnosis and oral swabbing. PNPLA3 gene was amplified by PCR from the swabs, and rs738409 genotype was determined by bidirectional sequencing. To profile the MASLD-associated microbiome, stool was collected from 170 participants. V4 16S rRNA gene sequencing was performed and reads were analysed using QIIME2 2024.10.1. R Studio 2022.12.0 was used for statistical analyses. Results: MASLD prevalence was 77.9%, with similar rates in all regions. FIB-4 scores <1.3 and >2.67 were detected in 55.3% and 7.4% of patients, respectively. Half of diabetics had PNPLA3-GG genotype, with the highest rates in Northwestern Argentina (64.9%; p=0.02 vs Buenos Aires). PNPLA3-GG genotype was an independent risk factor for FIB-4 score (p=0.0008), and a protective factor against HbA1c (p=0.004), fasting plasma glucose (p=0.008), and cholesterol levels (p=0.02). Marked regional differences were observed in microbiota diversity and composition in Argentina. After adjusting for geographical region, Negativibacillus genus was exclusively detected in diabetics with MASLD and GG carriers. Catenibacterium genus was related to FIB-4>2.67. Short-chain fatty acids-producing bacteria were linked to absence of MASLD. Conclusions: These specific signatures could be potentially useful as MASLD biomarkers for risk stratification in diabetics from Argentina.
Posted: 18 November 2025
What Is Aging, and How Can We Defeat It?
Maxim A. Kovalev
Posted: 18 November 2025
Bioelectrical Impedance Analysis and Phase Angle in Cancer Care: Prognosis, Nutrition, and Clinical Utility in 19.151 Patient
Maria Eduarda Oliveira Diniz,
Letícia Fóffano Monteiro Almeida,
Vitor Gabriel Soares Araújo,
Fernando Guimarães Teixeira,
Carly De Faria Coelho,
Rodrigo Alvaro Brandão Lopes-Martins
Posted: 18 November 2025
Genome-Wide Identification of the AMT Gene Family and Its Expression Profiling under Ammonium Nutrition and Pathogen in Wheat
Yanzhen Wang,
Jialu Li,
Xia Liu,
Rui Huang,
Menglin Lei,
Yaoyuan Zhang,
Guoqing Cui
Posted: 18 November 2025
Advances in Citrus Fruit Set and Development: A Review
Manuel Agustí,
Carmina Reig,
Amparo Martínez-Fuentes,
Carlos Mesejo
Posted: 18 November 2025
Lentinula edodes Cultured Extract Treated Mesenchymal-Derived Extracellular Vesicle Modulated Breast Cancer Stem Cells and Reprogramming of microRNAs
Farzaneh Sharifzad,
Nawal Alsadi,
Hamed Yasavoli-Sharahi,
Roqia Shahbazi,
Dylan Burger,
Chantal Matar
Posted: 18 November 2025
Climate Change and Fish-Parasite Relationships – A Review
Fernando Barreto Atroch,
Luis Filipe Rangel,
Camilo Ayra-Pardo,
Maria João Santos
Posted: 18 November 2025
Urea Coated with Iron and Zinc Oxide Nanoparticles Reduces Nitrogen Leaching in Sandy Soil and Improves the Performance of Young Corn Plants
Cleiton Farias de Oliveira,
Romildo da Silva Neves,
Thiago Felipe de Lima Arruda,
Sabrina dos Santos Costa,
Railene Hérica Carlos Rocha Araújo,
Ronaldo do Nascimento,
Alexandre Paiva da Silva,
Francisco Vaniés da Silva Sá,
Josinaldo Lopes Araujo Rocha
Posted: 18 November 2025
The Quantum Blueprint Formalism: An Informational Extension of Dissipative Quantum Field Theory in Living Systems
Marcus Schmieke
Posted: 18 November 2025
The Dual Structure of Mind and Life Can Explain Consciousness and Evolutionary Creativity Beyond Simulation
Pavel Straňák
Posted: 18 November 2025
Comparison of Normalization Methods for Selecting a Non-Small Cell Lung Cancer Marker Panel from Circulating miRNA RT-qPCR Data
Maria Yurievna Konoshenko,
Olga Evgenievna Bryzgunova,
Ekaterina Viktorovna Shutko,
Ekaterina Alekseevna Murina,
Antonina Aleksandrovna Ilyushchenko,
Yaroslava Mikhailovna Danilova,
Stanislav Dmitrievich Gorbunkov,
Kirill Alekseevich Zykov,
Pavel Petrovich Laktionov
Posted: 18 November 2025
Genome-Scale Phylogenetic Analyses Provide Insights of the Evolutionary History of Species Complexes in the Genus Fusarium
Shunsuke Nozawa,
Yosuke Seto,
Kyoko Watanabe
Posted: 18 November 2025
An Exploration of Aquatic Food Production and Marketing Mix in the Coastal States of Nigeria
Shehu L. Akintola,
Lateef A. Badmos,
Akinkunmi S Ojo,
Gbenga R. Ajepe,
Matthew A. Ajibade,
Mary A. Gbadamosi,
Victor T. Okomoda,
Idowu J Fasakin,
Sunil Siriwardena,
Charles Iyangbe
+2 authors
Posted: 18 November 2025
From Transcriptome to Therapy: The ncRNA Revolution in Neurodevelopmental Disorders
Jiayi Zhao,
Shanshan Li,
Xin Jin
Posted: 18 November 2025
Integrative Network Meta-Analysis Reveals Estrogen-Mediated RUNX2–PDLIM3–microRNA Crosstalk via Erg Signaling: Implications for Bone and Tissue Regeneration
Alshymaa Hassan
Estrogens govern the female reproductive cycle indefinitely. Estrogens, including estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4), regulate the female life cycle since early embryonic stages and play a crucial role in development, metabolism, and cell function. Throughout evolution, estrogen has regulated reproduction by affecting reproductive organ development and behavior. Estrogen impacts all vertebrates, including fish, and has a role in physiological and pathological states in both genders. The RUNX-2 gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with a Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. In 2022, a study was conducted to characterize novel genes that are regulated by estrogen binding to its receptors (α or β). The PDLIM3 gene, with a coefficient of variation (CV) of 0.083, received the most stable CV score among other genes. Our integrative research uncovers a unique regulatory cascade in which estrogen binding to ERα/β enhances PDLIM3 expression, then modulating the expression of miR-9, miR-10, and the newly identified miR-6769b, finally activating RUNX2 transcription.
Estrogens govern the female reproductive cycle indefinitely. Estrogens, including estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4), regulate the female life cycle since early embryonic stages and play a crucial role in development, metabolism, and cell function. Throughout evolution, estrogen has regulated reproduction by affecting reproductive organ development and behavior. Estrogen impacts all vertebrates, including fish, and has a role in physiological and pathological states in both genders. The RUNX-2 gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with a Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. In 2022, a study was conducted to characterize novel genes that are regulated by estrogen binding to its receptors (α or β). The PDLIM3 gene, with a coefficient of variation (CV) of 0.083, received the most stable CV score among other genes. Our integrative research uncovers a unique regulatory cascade in which estrogen binding to ERα/β enhances PDLIM3 expression, then modulating the expression of miR-9, miR-10, and the newly identified miR-6769b, finally activating RUNX2 transcription.
Posted: 18 November 2025
Emerging CRISPR Approaches for Countering Immune Evasion: Insight from Recent Studies
Sadam Abubakar,
Latifat Abdulsalam,
Lamin Fatty,
Rimsha Kanwal,
Muhammad Naeem,
Irshad Ahmad
Posted: 18 November 2025
Do Humans (and Animals) Think in Poetic Language?
Arturo Tozzi
Posted: 18 November 2025
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