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The Traditional Autonomic Narrative Misleads Yet Persists – A Critical Review and Proposed Alternative Narrative to Replace It
David Adelson
Posted: 17 November 2025
The Proximal Chemical Mandate Principle: A Framework for Invariant Biological Dynamic Optimization
Mukundan M
Posted: 17 November 2025
Promotion of Sweet Potato Growth and Yield by Decreasing Soil CO2 Concentrations with Forced Aeration
Yoshiaki Kitaya
Posted: 17 November 2025
SEQUENTION and the Superorganism: A Timeless, Projection-Based Framework for Collective Animal Behavior
Henry Arellano
Posted: 17 November 2025
Seed Coating Synergies: Harnessing Plant Growth Regulators to Strengthen Soybean Nodulation and Stress Resilience
Saranyapath Pairintra,
Nantakorn Boonkerd,
Neung Teaumroong,
Kamolchanok Umnajkitikorn
Soybean (Glycine max) is a globally important crop, but its productivity is often limited by suboptimal nodulation and nitrogen fixation, particularly under stress conditions. Bradyrhizobium diazoefficiens strain USDA110 is widely applied to enhance nodulation, yet its efficiency can be further improved by phytohormone modulation. This study examined the effects of seed coatings containing plant growth regulators (PGRs)—acetylsalicylic acid (ASA), aminoethoxyvinylglycine (AVG), indole-3-butyric acid (IBA), and 6-benzylaminopurine (BAP)—at varying concentrations from 5 – 500 nM, in combination with USDA110, on nodulation, nitrogenase activity, ethylene emission, physiological traits, and yield of soybean cultivar CM60. Laboratory assays identified 50 nM AVG, 5 nM IBA, and 5 nM ASA as optimal treatments, significantly enhancing nodule number and nitrogenase activity. Greenhouse trials under both well-watered and water-deficit conditions further demonstrated that USDA110 combined with AVG or IBA markedly improved photosynthesis, stomatal conductance, transpiration, plant height, and yield components compared with USDA110 or PGRs applied alone. Notably, USDA110 + AVG/IBA treatments sustained higher seed weight under drought, indicating strong synergistic effects in mitigating stress impacts. These findings highlighted that integrating USDA110 with specific PGRs represented a promising strategy to optimize nitrogen fixation and enhanced soybean productivity under both favorable and challenging conditions.
Soybean (Glycine max) is a globally important crop, but its productivity is often limited by suboptimal nodulation and nitrogen fixation, particularly under stress conditions. Bradyrhizobium diazoefficiens strain USDA110 is widely applied to enhance nodulation, yet its efficiency can be further improved by phytohormone modulation. This study examined the effects of seed coatings containing plant growth regulators (PGRs)—acetylsalicylic acid (ASA), aminoethoxyvinylglycine (AVG), indole-3-butyric acid (IBA), and 6-benzylaminopurine (BAP)—at varying concentrations from 5 – 500 nM, in combination with USDA110, on nodulation, nitrogenase activity, ethylene emission, physiological traits, and yield of soybean cultivar CM60. Laboratory assays identified 50 nM AVG, 5 nM IBA, and 5 nM ASA as optimal treatments, significantly enhancing nodule number and nitrogenase activity. Greenhouse trials under both well-watered and water-deficit conditions further demonstrated that USDA110 combined with AVG or IBA markedly improved photosynthesis, stomatal conductance, transpiration, plant height, and yield components compared with USDA110 or PGRs applied alone. Notably, USDA110 + AVG/IBA treatments sustained higher seed weight under drought, indicating strong synergistic effects in mitigating stress impacts. These findings highlighted that integrating USDA110 with specific PGRs represented a promising strategy to optimize nitrogen fixation and enhanced soybean productivity under both favorable and challenging conditions.
Posted: 17 November 2025
Chronic Stress Leads to Differentiation of Mice by Glucocorticoid Sensitivity into Groups Characterized by Specific Behavioral Phenotype
Polina Ritter,
Rasha Salman,
Yuliya Ryabushkina,
Natalya Bondar
Posted: 17 November 2025
Identification of Molecular Signature for Heart Ischemia Diagnosis
Identification of Molecular Signature for Heart Ischemia Diagnosis
Felipe Leal Valentim
Posted: 17 November 2025
The Branching Process: A General Conceptual Framework for Addressing Current Ecological and Evolutionary Questions
Xuhua Xia
Posted: 17 November 2025
Morphology, Phytochemistry, and Genetics-Based Analysis of Endemic Species Belonging to Allium sect. Schoenoprasum (Amaryllidaceae) from the Kazakhstan Altai
Aidar Sumbembayev,
Zhanar Aimenova,
Alevtina Danilova,
Olga Lagus,
Zhanar Takiyeva,
Aidyn Orazov
The genus Allium L. (Amaryllidaceae) comprises ecologically flexible species widespread across mountain ecosystems, yet the relationships among morphology, environment, and genetics within section Schoenoprasum in Central Asia remain poorly understood. This study investigated four taxa – A. ledebourianum, A. ivasczenkoae, A. ubinicum, and A. schoenoprasum – from the Kazakhstan Altai to assess their morphological variation, ecological preferences, phytochemical activity, and genetic relationships. Populations occurred on gentle chernozem slopes under humid, nutrient-rich conditions and showed stable regeneration dominated by young individuals. Morphometric analyses revealed pronounced interspecific differentiation: A. ledebourianum attained the greatest height and umbel size, whereas A. ubinicum was smallest but possessed proportionally larger floral organs. Principal component analysis explained 94% of total variance, distinguishing A. ubinicum and A. schoenoprasum from the remaining taxa. Floral traits correlated significantly with temperature, moisture, and soil reaction, indicating strong environmental influence on phenotype. Extract assays showed variable bioactivity, with A. ubinicum displaying the highest antioxidant potential (IC₅₀ = 88 µL) and highest cytotoxicity (LC50 of 5.9 μg/mL), while A. ledebourianum shows no antioxidant activity and the lowest toxicity (LC₅₀ of 10.9 μg/mL). Phylogenetic reconstruction using matK, rbcL, and psbA–trnH chloroplast markers confirmed close affinity between A. ledebourianum and A. ivasczenkoae, while A. ubinicum formed a distinct lineage. Together, morphological, ecological, and molecular data highlight the Kazakhstan Altai as a center of diversification for section Schoenoprasum. These results emphasize the adaptive plasticity of endemic Allium species and their potential as sources of valuable bioactive compounds, underscoring the importance of conserving genetically and morphologically diverse populations in mountain ecosystems.
The genus Allium L. (Amaryllidaceae) comprises ecologically flexible species widespread across mountain ecosystems, yet the relationships among morphology, environment, and genetics within section Schoenoprasum in Central Asia remain poorly understood. This study investigated four taxa – A. ledebourianum, A. ivasczenkoae, A. ubinicum, and A. schoenoprasum – from the Kazakhstan Altai to assess their morphological variation, ecological preferences, phytochemical activity, and genetic relationships. Populations occurred on gentle chernozem slopes under humid, nutrient-rich conditions and showed stable regeneration dominated by young individuals. Morphometric analyses revealed pronounced interspecific differentiation: A. ledebourianum attained the greatest height and umbel size, whereas A. ubinicum was smallest but possessed proportionally larger floral organs. Principal component analysis explained 94% of total variance, distinguishing A. ubinicum and A. schoenoprasum from the remaining taxa. Floral traits correlated significantly with temperature, moisture, and soil reaction, indicating strong environmental influence on phenotype. Extract assays showed variable bioactivity, with A. ubinicum displaying the highest antioxidant potential (IC₅₀ = 88 µL) and highest cytotoxicity (LC50 of 5.9 μg/mL), while A. ledebourianum shows no antioxidant activity and the lowest toxicity (LC₅₀ of 10.9 μg/mL). Phylogenetic reconstruction using matK, rbcL, and psbA–trnH chloroplast markers confirmed close affinity between A. ledebourianum and A. ivasczenkoae, while A. ubinicum formed a distinct lineage. Together, morphological, ecological, and molecular data highlight the Kazakhstan Altai as a center of diversification for section Schoenoprasum. These results emphasize the adaptive plasticity of endemic Allium species and their potential as sources of valuable bioactive compounds, underscoring the importance of conserving genetically and morphologically diverse populations in mountain ecosystems.
Posted: 17 November 2025
Modulation of Oncogenic NOTCH Signaling in Highly Aggressive Neoplasia by Targeting the γ-Secretase Complex: A Systematic Review
Pablo Martínez-Gascueña,
María-Luisa Nueda,
Victoriano Baladrón
Posted: 17 November 2025
Circulating miR-1246 as a Diagnostic and Prognostic Biomarker in Dengue Infection: A Case–Control Study
Frienson Pradhan,
Kriti Rajbhandari,
Rasika Ghulu,
Vishesh Rajbhandari,
Ashna Dhakal,
Amol Dahal
Posted: 17 November 2025
Germplasm Pools for Quinoa Improvement
Kayla B. Stephensen,
Sabrina Costa-Tártara,
Riley L. Roser,
David E. Jarvis,
Peter J. Maughan,
Eric N. Jellen
Posted: 17 November 2025
Similarity Between Symptoms of Dementia and Brain Tumors and the Impact of Diagnostic Delay
Isabella Chander
Posted: 17 November 2025
From Editing Genes to Orchestrating Networks: CRISPR and the Future of Precision Oncology
Ashutosh Kumar Maurya,
Hitakankshi Naik,
Sachidananda Behera,
Vikash Kumar Nayak,
Rajendra Pilankatta
Posted: 17 November 2025
Edaphic Determinants of Biomass Hyperdominance in Large Trees of the Amazon
Manuelle Pereira,
Jorge Reategui-Betancourt,
Robson Borges de Lima,
Paulo Bittencourt,
Eric Gorgens,
Gustavo Abreu,
Marcelino Guedes,
José Silva,
Carla de Sousa,
Joselane Priscila da Silva
+2 authors
Posted: 17 November 2025
Training Load Oscillation and Epigenetic Plasticity: Molecular Pathways Connecting Energy Metabolism and Athletic Personality
Dan Cristian Mănescu
Posted: 17 November 2025
A Naked Lyophilized mRNA Vaccine Against Seasonal Influenza, Administered by Jet Injection, Provides a Robust Response in Immunized Animals
Sergei V. Sharabrin,
Svetlana I. Krasnikova,
Denis N. Kisakov,
Mariya B. Borgoyakova,
Vladimir A. Yakovlev,
Elena V. Tigeeva,
Ekaterina V. Starostina,
Victoria R. Litvinova,
Lyubov A. Kisakova,
Danil I. Vahitov
+8 authors
Posted: 17 November 2025
Body Heating and Viruses: A Thermophysiological Approach
Lev Neymotin
This study introduces the Body Heating Theory (BHT)—a physiological model explaining how controlled thermogenesis produced through brief, vigorous muscular activity can suppress viral replication and enhance immune performance. Integrating concepts from fever physiology, exercise immunology, and viral kinetics, the paper reframes body heating as a measurable, self-regulated defense mechanism rather than a secondary symptom of infection. Most respiratory viruses replicate optimally at 33–36 °C, while immune efficiency peaks between 37–39 °C. Within this narrow overlap, even a 0.5–1 °C rise in core temperature can shift the competitive balance toward the host. Early muscular activation—initiated during the first 24–48 hours after exposure—accelerates immune modulation, increases lymphatic flow, and limits viral expansion by shortening one or more replication cycles. This effect parallels the natural benefits of fever but can be safely achieved through deliberate exercise-based thermogenesis. The theory introduces a “grace period” in which temperature elevation advances immune activation ahead of viral kinetics, providing a practical rationale for early intervention. Implementation through rhythmic resistance exercise, such as IsoTone sessions, demonstrates a portable, non-pharmaceutical method for maintaining immune readiness and mitigating common colds. By linking temperature, motion, and immunity into one coherent framework, BHT positions controlled thermogenesis as a foundational element of preventive medicine and a testable model for integrating physiology, behavior, and health.
This study introduces the Body Heating Theory (BHT)—a physiological model explaining how controlled thermogenesis produced through brief, vigorous muscular activity can suppress viral replication and enhance immune performance. Integrating concepts from fever physiology, exercise immunology, and viral kinetics, the paper reframes body heating as a measurable, self-regulated defense mechanism rather than a secondary symptom of infection. Most respiratory viruses replicate optimally at 33–36 °C, while immune efficiency peaks between 37–39 °C. Within this narrow overlap, even a 0.5–1 °C rise in core temperature can shift the competitive balance toward the host. Early muscular activation—initiated during the first 24–48 hours after exposure—accelerates immune modulation, increases lymphatic flow, and limits viral expansion by shortening one or more replication cycles. This effect parallels the natural benefits of fever but can be safely achieved through deliberate exercise-based thermogenesis. The theory introduces a “grace period” in which temperature elevation advances immune activation ahead of viral kinetics, providing a practical rationale for early intervention. Implementation through rhythmic resistance exercise, such as IsoTone sessions, demonstrates a portable, non-pharmaceutical method for maintaining immune readiness and mitigating common colds. By linking temperature, motion, and immunity into one coherent framework, BHT positions controlled thermogenesis as a foundational element of preventive medicine and a testable model for integrating physiology, behavior, and health.
Posted: 17 November 2025
A Monoclonal Antibody-Based Indirect Competitive ELISA for Detecting Goose Astrovirus Antibodies
Jun-Feng Lv,
Yanhan Liu,
Zhihui Liu,
Zhonghao Wang,
Wenxuan She,
Cun Liu,
Ye Tian
Posted: 17 November 2025
Harnessing Setaria as a Model for C4 Plant Adaptation to Abiotic Stress
Juan Gomes,
João Fernandes-Esteves,
João Travassos-Lins,
Andres Acevedo,
Tamires Rodrigues,
Marcio Alves-Ferreira
Posted: 17 November 2025
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