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A Systematic Method for Evaluating the Generalizability of Mobile-Specific Research: Green Computing as a Case Study
Robin Nunkesser
Posted: 06 January 2026
Anthropometric Indices and Markers of Atherothrombotic Risk in Subjects with Primary Hyperpathyroidism
Anda Mihaela Naciu
,Eleonora Sargentini
,Marco Bravi
,Annunziata Nusca
,Francesco Grigioni
,Luigi Bonifazi Meffe
,Nicola Napoli
,Andrea Palermo
,Gaia Tabacco
Background. Both primary hyperparathyroidism (PHPT) and chronic hypoparathyroidism (HypoPT) are associated with the onset and development of cardiovascular diseases (CVDs). Especially PHPT is accompanied by the presence of elevated atherothrombotic risk, while the importance of traditional and new anthropometric indices to reflect the cardiovascular risk remains uncertain in this condition. This study aims to investigate whether novel and traditional anthropometric indices distinguish PHPT and their correlation with atherothrombotic risk. Methods. 40 Subjects with HypoPT, 40 PHPT and 40 age- and sex-matched control subjects were consecutively enrolled for the evaluation of flow-mediated vasodilation (FMD) and carotid intimal-media thickness (IMT). A blood sample was collected for calcium-phosphate metabolism, PTH, TSH and 25-hydroxy vitamin D evaluation. Physical examination was performed to obtain traditional anthropometric parameters and derived indices of adiposity and cardiometabolic risk (waist height ratio (WHtR) and waist hip ratio (WHR) and conicity index (CI)). Results. The PHPT group showed higher central adiposity indices (WHtR p=0.002, and CI p=0.008). Among patients with parathyroid disorders, PHPT subjects display the highest reduction of FMD (p<0.001) and a marked increase of IMT (p<0.001). In the Ctrl group, WHtR showed a weak-to-moderate positive association with IMT (r=0.381, p=0.018). In the PHPT group, no anthropometric index was significantly correlated with IMT or FMD (all p>0.05). Conclusions. WHtR and CI provide evidence of increased central fat adiposity in PHPT but do not account for impaired atherothrombotic risk, indicating that anthropometric indices may lack relevance to cardiovascular risk in this condition and emphasising the importance of a specific assessment profile.
Background. Both primary hyperparathyroidism (PHPT) and chronic hypoparathyroidism (HypoPT) are associated with the onset and development of cardiovascular diseases (CVDs). Especially PHPT is accompanied by the presence of elevated atherothrombotic risk, while the importance of traditional and new anthropometric indices to reflect the cardiovascular risk remains uncertain in this condition. This study aims to investigate whether novel and traditional anthropometric indices distinguish PHPT and their correlation with atherothrombotic risk. Methods. 40 Subjects with HypoPT, 40 PHPT and 40 age- and sex-matched control subjects were consecutively enrolled for the evaluation of flow-mediated vasodilation (FMD) and carotid intimal-media thickness (IMT). A blood sample was collected for calcium-phosphate metabolism, PTH, TSH and 25-hydroxy vitamin D evaluation. Physical examination was performed to obtain traditional anthropometric parameters and derived indices of adiposity and cardiometabolic risk (waist height ratio (WHtR) and waist hip ratio (WHR) and conicity index (CI)). Results. The PHPT group showed higher central adiposity indices (WHtR p=0.002, and CI p=0.008). Among patients with parathyroid disorders, PHPT subjects display the highest reduction of FMD (p<0.001) and a marked increase of IMT (p<0.001). In the Ctrl group, WHtR showed a weak-to-moderate positive association with IMT (r=0.381, p=0.018). In the PHPT group, no anthropometric index was significantly correlated with IMT or FMD (all p>0.05). Conclusions. WHtR and CI provide evidence of increased central fat adiposity in PHPT but do not account for impaired atherothrombotic risk, indicating that anthropometric indices may lack relevance to cardiovascular risk in this condition and emphasising the importance of a specific assessment profile.
Posted: 06 January 2026
Managing Borderless Project Teams: PM Playbooks for Iterative Delivery
Abhi Gaikwad
Posted: 06 January 2026
Adaptive Implementation of Project Oversight Systems in Resource-Constrained Enterprises: An Organizational Case Insight
Abhijit Gaikwad
Posted: 06 January 2026
Performance-Based Seismic Resistance Assessment of Reinforced Slopes Using the Force-Equilibrium Finite Displacement Method
Ching-Chuan Huang
Posted: 06 January 2026
Dissecting AI-related Paper Retraction Across Countries and Institutions
Khalid Saqr
Research integrity is currently besieged by a surge in synthetic manuscripts. A forensic workflow is operationalized herein to isolate and quantify ``computer-aided'' misconduct within the global scholarly record. A corpus of \( N=3,974 \) retracted DOIs sourced from the Retraction Watch Database was analyzed, with records cross-linked to institutional metadata via the OpenAlex API. Through the application of fractional attribution modeling and the calculation of Shannon entropy (\( H \)) for retraction rationales, a distinct geographic schism in fraud typologies was identified. High-output hubs, specifically China and India, exhibit high reason entropy (\( H > 4.2 \)), where ``Computer-Aided Content'' frequently clusters with established ``Paper Mill'' signatures. These AI-driven retractions exhibit a compressed median Time-to-Retraction (TTR) of \( \sim \)600 days, nearly twice as fast as the \( 1,300 \)+ day latencies observed in the US and Japan---where retractions remain skewed toward complex image and data manipulation. The data suggests that while traditional fraud has not been replaced by generative AI, it has been effectively industrialized. It is concluded that current post-publication filters fail to keep pace with the near-zero marginal cost of synthetic content, necessitating a shift toward provenance-based verification.
Research integrity is currently besieged by a surge in synthetic manuscripts. A forensic workflow is operationalized herein to isolate and quantify ``computer-aided'' misconduct within the global scholarly record. A corpus of \( N=3,974 \) retracted DOIs sourced from the Retraction Watch Database was analyzed, with records cross-linked to institutional metadata via the OpenAlex API. Through the application of fractional attribution modeling and the calculation of Shannon entropy (\( H \)) for retraction rationales, a distinct geographic schism in fraud typologies was identified. High-output hubs, specifically China and India, exhibit high reason entropy (\( H > 4.2 \)), where ``Computer-Aided Content'' frequently clusters with established ``Paper Mill'' signatures. These AI-driven retractions exhibit a compressed median Time-to-Retraction (TTR) of \( \sim \)600 days, nearly twice as fast as the \( 1,300 \)+ day latencies observed in the US and Japan---where retractions remain skewed toward complex image and data manipulation. The data suggests that while traditional fraud has not been replaced by generative AI, it has been effectively industrialized. It is concluded that current post-publication filters fail to keep pace with the near-zero marginal cost of synthetic content, necessitating a shift toward provenance-based verification.
Posted: 06 January 2026
Traditional Alliance of Women in the Socio-Political Sphere and Resilient Subject to Climate Change: The Case of Guinea-Bissau
Ana Belén Cruz Valiño
Posted: 06 January 2026
Metabolic Reprogramming Following Mitochondrial Transfer Between IDH2 Mutant Chondrosarcoma Cells and a Normal B-Cell Line
Caleb Wyckoff
,Christopher Osgood
,Ellen Jing
,Michael Stacey
Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma, cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers. Mitochondrial-mediated transfer between cancer and recipient cells is a significant event that impacts the metabolism of both cell types. The presence of intercellular nanotubular structures between IDH2 mutant chondrosarcoma cells motivated investigation into mitochondria-mediated physiological alterations resulting from mitochondrial transfer to immune cells. Mitochondrial transfer is a two-way process, and we hypothesized that mitochondria derived from IDH2-mutant chondrosarcoma cells co-cultured with normal cells occurred between cells through tunneling nanotubes. We further hypothesize that disruption of the actin cytoskeleton will inhibit this transfer. Our objectives were 1). Quantify the exchange and directionality of mitochondria via nanotubes between IDH2 mutant cells and wild-type cells and modulate transfer via cytoskeletal inhibitors, and 2) measure metabolic changes in cells following transfer. The experimental data acquired here increased our understanding of the molecular mechanisms behind the progression of IDH2 cancers as they interact with normal cells in the tumor microenvironment, advancing our understanding of intercellular communication in cancer biology.
Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma, cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers. Mitochondrial-mediated transfer between cancer and recipient cells is a significant event that impacts the metabolism of both cell types. The presence of intercellular nanotubular structures between IDH2 mutant chondrosarcoma cells motivated investigation into mitochondria-mediated physiological alterations resulting from mitochondrial transfer to immune cells. Mitochondrial transfer is a two-way process, and we hypothesized that mitochondria derived from IDH2-mutant chondrosarcoma cells co-cultured with normal cells occurred between cells through tunneling nanotubes. We further hypothesize that disruption of the actin cytoskeleton will inhibit this transfer. Our objectives were 1). Quantify the exchange and directionality of mitochondria via nanotubes between IDH2 mutant cells and wild-type cells and modulate transfer via cytoskeletal inhibitors, and 2) measure metabolic changes in cells following transfer. The experimental data acquired here increased our understanding of the molecular mechanisms behind the progression of IDH2 cancers as they interact with normal cells in the tumor microenvironment, advancing our understanding of intercellular communication in cancer biology.
Posted: 06 January 2026
Promotion of Green Bussiness for Climate Neutrality: New Proposals for Carbon Farming
Carolina Barreto Leite
Posted: 06 January 2026
Particles’ Mass Relationship to the Square of the Magnetic Flux Quantum, and the Quarks at the Three Energy Levels Within the Baryons
Israel Fried
Posted: 06 January 2026
Association Between Daily Steps Measured by Accelerometry and Diabetes in ELSA-Brasil Participants
Association Between Daily Steps Measured by Accelerometry and Diabetes in ELSA-Brasil Participants
Matheus Hortélio
,Maria da Conceição Chagas de Almeida
,Sheila Maria Alvim Matos
,Cristiano Penas Seara Pitanga
,Ciro Oliveira Queiroz
,Francisco José Gondim Pitanga
Diabetes mellitus is a serious chronic disease whose main characteristic is hyperglycemia (increased blood glucose), accompanied by changes in lipid and protein metabolism. For individuals with diabetes mellitus, physical activity provides significant benefits and is an essential tool for metabolic management. Daily step counting, measured with AI support through wearable devices, can be an important metric of physical activity for the prevention and treatment of this disease if performed regularly and respecting a minimum daily amount. Objective: To investigate the association between daily steps and diabetes and to determine what minimum amount should be performed daily for a protective effect in participants of the Longitudinal Study of Adult Health. Methods: The study was cross-sectional and participants from the 2nd segment (2016-2018) were analyzed, with a sample of 12,636 participants. The dependent variable was diabetes, assessed by laboratory tests, and the independent variable was daily steps counting, assessed by accelerometry. The associations between the dependent and independent variables were analyzed using logistic regression. The odds ratio with 95% CI was estimated. Results: An association was found between daily steps and diabetes (OR = 0.76, CI = 0.70-0.83), in addition to the cutoff point of 6,880 with area under the ROC curve = 0.58 (CI = 0.57-0.59). Conclusion: Based on the results found in this study, we can conclude that the number of daily steps has a protective effect against diabetes, especially in men and women with abdominal obesity and in men with moderate/vigorous leisure-time physical activity.
Diabetes mellitus is a serious chronic disease whose main characteristic is hyperglycemia (increased blood glucose), accompanied by changes in lipid and protein metabolism. For individuals with diabetes mellitus, physical activity provides significant benefits and is an essential tool for metabolic management. Daily step counting, measured with AI support through wearable devices, can be an important metric of physical activity for the prevention and treatment of this disease if performed regularly and respecting a minimum daily amount. Objective: To investigate the association between daily steps and diabetes and to determine what minimum amount should be performed daily for a protective effect in participants of the Longitudinal Study of Adult Health. Methods: The study was cross-sectional and participants from the 2nd segment (2016-2018) were analyzed, with a sample of 12,636 participants. The dependent variable was diabetes, assessed by laboratory tests, and the independent variable was daily steps counting, assessed by accelerometry. The associations between the dependent and independent variables were analyzed using logistic regression. The odds ratio with 95% CI was estimated. Results: An association was found between daily steps and diabetes (OR = 0.76, CI = 0.70-0.83), in addition to the cutoff point of 6,880 with area under the ROC curve = 0.58 (CI = 0.57-0.59). Conclusion: Based on the results found in this study, we can conclude that the number of daily steps has a protective effect against diabetes, especially in men and women with abdominal obesity and in men with moderate/vigorous leisure-time physical activity.
Posted: 06 January 2026
Inter-Row Reflective Film Mulching Revealed the Regulation of Ground-Reflected Light on the Grape Fruit Flavoromics
Ning Shi
,Hao-Cheng Lu
,Meng-Bo Tian
,Ming-Yu Li
,Changqing Duan
,Jun Wang
,Xiao-Feng Shi
,Fei He
Posted: 06 January 2026
Improved BLCD and Its Application in Gear Surface Defect Detection
Yingjie Tang
,Zhantao Wu
,Dongxu Liu
,Junsheng Cheng
,Baoqing Li
Posted: 06 January 2026
Quantum Information Copy Time (QICT): Operational Definition, Minimal Locality Bounds, Hydrodynamic Susceptibilities, and a Programmatic Outlook
Sacha Mohamed
Posted: 06 January 2026
Temporal Dynamics of Dual-Task Interference in High-Performance Athletes
Alan de Jesús Gómez Rosales
,Eduardo Enrique Veas
,Leticia Chacón Gutiérrez
,Luis Alberto Barradas-Chacón
High-performance athletes operate in demanding environments requiring simultaneous coordination of multiple cognitive and motor tasks. This study developed a novel dual-task protocol combining continuous visuomotor tracking with discrete attentional vigilance to investigate temporal dynamics of dual-task interference in young athletes. Thirty-six participants from interceptive and static sports performed the dual-task paradigm while behavioral performance metrics were continuously recorded. Adapting event-related potential methodology to behavioral data, we computed Event-Related Behavioral Potentials (ERBPs) to characterize time-locked performance changes. Results revealed a significant Dual-Task Effect (DTE) with distinct temporal components: an early perceptual interference phase around 450 ms post-stimulus and a later decision-execution phase extending to 1400 ms. Friedman tests confirmed significant performance differences across temporal windows (\( \chi^2 \)(4) = 85.32, p < 0.001), with performance returning to baseline by 1500 ms. The ERBP analysis enabled quantification of DTE amplitude, latency, and duration—providing novel metrics for continuous assessment of cognitive-motor interference. Target events elicited pronounced performance degradation compared to non-target events (peak difference: 10.5 px, latency difference: 350 ms), indicating sensitivity to decision-making processes beyond motor execution. Exploratory comparisons between sport groups revealed trends suggesting differential interference patterns, though no significant between-group differences emerged. These findings demonstrate that ERBP analysis offers a powerful framework for dissecting temporal dynamics of dual-task performance, with implications for understanding attentional resource allocation in high-demand environments and potential applications in sports training and cognitive assessment.
High-performance athletes operate in demanding environments requiring simultaneous coordination of multiple cognitive and motor tasks. This study developed a novel dual-task protocol combining continuous visuomotor tracking with discrete attentional vigilance to investigate temporal dynamics of dual-task interference in young athletes. Thirty-six participants from interceptive and static sports performed the dual-task paradigm while behavioral performance metrics were continuously recorded. Adapting event-related potential methodology to behavioral data, we computed Event-Related Behavioral Potentials (ERBPs) to characterize time-locked performance changes. Results revealed a significant Dual-Task Effect (DTE) with distinct temporal components: an early perceptual interference phase around 450 ms post-stimulus and a later decision-execution phase extending to 1400 ms. Friedman tests confirmed significant performance differences across temporal windows (\( \chi^2 \)(4) = 85.32, p < 0.001), with performance returning to baseline by 1500 ms. The ERBP analysis enabled quantification of DTE amplitude, latency, and duration—providing novel metrics for continuous assessment of cognitive-motor interference. Target events elicited pronounced performance degradation compared to non-target events (peak difference: 10.5 px, latency difference: 350 ms), indicating sensitivity to decision-making processes beyond motor execution. Exploratory comparisons between sport groups revealed trends suggesting differential interference patterns, though no significant between-group differences emerged. These findings demonstrate that ERBP analysis offers a powerful framework for dissecting temporal dynamics of dual-task performance, with implications for understanding attentional resource allocation in high-demand environments and potential applications in sports training and cognitive assessment.
Posted: 06 January 2026
What Distinguishes AI-Generated from Human Writing? A Rapid Review of the Literature
Georgios Georgiou
Posted: 06 January 2026
The Psychiatrization of Negative Emotions
Luis Fonseca
,Francisca Rego
,Rui Nunes
Posted: 06 January 2026
Experimental Evaluation of Different Optical Fibers for Micro-Invasive Soft Tissue Ablation with a 1064 nm Diode Laser System
Danny Di Minno
,Cosimo Trono
,Lorenzo Capineri
,Alessia Blundo
,Giovanni Masotti
Posted: 06 January 2026
Auditing Inferential Blind Spots: A Framework for Evaluating Forensic Coverage in Network Telemetry Architectures
Mehrnoush Vaseghipanah
,Sam Jabbehdari
,Hamidreza Navidi
Posted: 06 January 2026
A Fresh Look at CMB Polarization: Last Scattering
John Botke
Posted: 06 January 2026
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