Switched-mode power supplies (SMPS) often utilize electrolytic capacitors due to their substantial energy density and economical pricing. However, their ability to function at low temperatures is essential for dependable operation in several sectors, including telecommunications, automotive, and aerospace. This study includes an experimental evaluation of how well standard SMPS electrolytic capacitors operate at low temperatures. This paper investigates the suitability of standard electrolytic capacitors used in switched-mode power supplies (SMPS) for low-temperature applications. The experimental evaluation exposed the capacitors to temperatures ranging from - 5 ∘C to - 40 ∘C, assessing capacitance (Cp), impedance (Z), dissipation factor (DF), and equivalent series resistance (ESR) at each temperature. The capacitor’s time-domain electrical signals were analyzed using the Pearson correlation coefficient to extract discriminative features. These features were input into an Artificial Neural Network (ANN) for training and testing. Results indicated a significant impact of low temperatures on capacitor performance. Capacitance decreased with lower temperatures, while ESR and leakage current increased, affecting stability and efficiency. Impedance proved to be a valuable diagnostic tool for identifying potential capacitor failure, showing a 98.44% accuracy drop at - 5 degrees and 88.75% at the peak temperature, indicating proximity to the manufacturer’s specified limit. The study suggests further research and development to improve electrolytic capacitors’ performance in SMPS systems under cold conditions to enhance efficiency and reliability.

The cold-formed steel sections are becoming popular for different steel structures because it has a high resistance against the different straining actions with minimum weight compared with hard steel sections. Recently, the perforated cold-formed steel (PCFS) sections are used in many applications such as storage perforated uprights racks. Experimental research into the behaviour of steel storage rack uprights subjected to axial compression is presented in this paper. The material qualities of cold-formed steel uprights were determined by tensile tests. The seventeen perforated specimens were examined under axial compression, with five different cross-sections, three different web heights and thicknesses, and varying lengths. The study's goals are to find out how perforations affect the performance and failure mode of steel storage rack uprights, discuss the interaction of distortional and global buckling, and verify the accuracy of using the Direct Strength Method (DSM) for predicting the ultimate strength of uprights failing in buckling interactions for perforated uprights. It is found that the failure modes of perforated specimens with stiffeners generally cannot be well predicted by the Direct Strength Method. But when the modifications proposed by Xianzhong Zhao etc. al. are used, their accuracy is acceptable.

Study of RNA-protein interactions and identification of RNA targets are among the key aspects of understanding the RNA biology. Currently, various methods are available to investigate these interactions, in particular, RNA pulldown assay. In the present paper, a method based on the HaloTag technology is presented that is called Halo-RPD (HaloTag RNA PullDown). The proposed protocol uses plants with stable fusion protein expression and the MagneBeads magnetic beads to capture RNA-protein complexes directly from the cytoplasmic lysate of transgenic A. thaliana plants. The key stages described in the paper are as follows: 1) preparation of the magnetic beads 2) tissue homogenization and collection of control samples 3) precipitation and wash of RNA-protein complexes; 4) evaluation of protein binding efficacy; 5) RNA isolation; 6) analysis of the obtained RNA. Recommendations for better NGS assay designs are provided.

Late pear cultivars, such as ‘Conference’, can be stored for a long period, with their storability depending on storage conditions. A three-year study (2011-2013) compared the impact of half-year storage using four technologies – normal atmosphere, normal atmosphere + 1-methylcyclopropene (1-MCP), controlled atmosphere, controlled atmosphere + 1-MCP – on the quality parameters of ‘Conference’ pears, such as mass loss, firmness, total soluble solids, acidity, antioxidant capacity, and the incidence of diseases and disorders. Additionally, the study analysed different storage conditions in terms of profitability, based on the market prices for pears in the seasons during which the pears were stored. The storage conditions had a very strong influence on the fruit quality parameters, and was found to affect most visibly the mass loss and the incidence of postharvest diseases and disorders. The storage of ‘Conference’ pears for 180 days in normal atmosphere is not economically viable, even if the fruit is subjected to 1-MCP treatment.

Studying the interaction between the upper ocean and the typhoons is crucial to improve our understanding of heat and momentum exchange between the ocean and the atmosphere. In recent years, the upper ocean responses to typhoons have received considerable attention. The sea surface cooling (SSC) process has been repeatedly discussed. In the present work, case studies were examined on five strong and super typhoons that occurred in 2016—LionRock, 1610; Meranti, 1614; Malakas, 1616; Megi, 1617; and Chaba 1618—to search for more evidence and new features of typhoon’s impact on the sea surface environment. The typhoon monitoring data from the Central Meteorological Observatory, the sea surface temperature (SST) data from satellite microwave and infrared remote sensing, and the sea surface height anomaly (SSHA) data from satellite altimeters were used to analyze in detail: the SSC features caused by typhoons, the relationship between the SSC and the typhoon travelling speed, and the variations in cold and warm eddies during typhoon passage. Results showed that: (1) SSC generally occurred during typhoon passage and the degree of SSC was always determined by the strength and the travelling speed of the typhoon, as well as the initial SST. (2) One day before or on the day of typhoon passage, the SSHA slightly increased due to low surface pressure. After the typhoon passed, the SSHA obviously decreased along with the SSC. The pre-existing positive SSHAs, which always represent warm eddies, decreased or disappeared during typhoon passage, whereas negative SSHAs or cold eddies were enhanced. (3) New cold eddies were generated, especially at the turning points of the typhoon path. The presence of warm eddies is suggested to have a strengthening effect on the typhoons.

In order to reveal the frost heaving mechanism of void water behind the lining of high-speed railway tunnels in cold regions，the voids were first classified according to the positional relationship between voids and waterproof panels，and then the water supply and discharge conditions of different types of voids were investigated，then the influence of the excretion conditions on the frost heave force was experimentally studied. Based on these conditions，circular wedge-shaped and flying saucer-shaped void freezing models were established to analyze the evolution process of accumulated water frost heave. Then，according to the relative position of the excretion channel and the void，the excretion coefficient was introduced，and the calculation method of the frost heaving force of the voided water was proposed，and the influencing factors and laws of the frost-heave force were revealed. The results are shown as follows: 1) The blockage of the excretion channel will lead to the generation of frost heaving force; 2) The freezing and thawing process of the water within the cavity develops from the thinnest part of the void edge to the thicker part，and the process of frost heave-thaw，water replenishment-re-freeze heave of the water within the cavity leads to greater and greater frost heave force; 3) The frost-heaving force of the water within cavity is controlled by the void height and the position of the excretion channel. The larger the cavity height is or the closer the excretion channel is to the bottom surface of the void，the greater the frost-heave force is.

Cold chain logistics of Agricultural Products demand forecasting can provide the scientific basis for the country to formulate logistics strategy, which further promotes the development of social economy and the improvement of living standards in China. In this paper, a new mathematical combined model is proposed to Agricultural Products Demand. Shandong, one of a China’s province, serves as the main producer and distributor of agricultural products. Based on the index system created from multiple related factors influencing cold chain logistics demand of agricultural products in Shandong, this paper employs principal component analysis to reduce the dimension of various indexes and predicts principal components with time series. Thereafter, multiple linear regression model and neural network model were constructed to forecast the cold chain logistics demand of agricultural products in Shandong, and their combined forecast models were compared. What's more, the paper provides insight for reference and decision-making concerning the development of cold chain logistics industry of agricultural products in Shandong province.

Interfaces between layers in 3D-printed elements produced by extrusion-based material deposition were investigated on both macro- and micro-scales. On the macro-scale, compression and bend tests were performed on two 3D-printable cement-based compositions (3PCs), namely C1 and C2. The influences of binder composition and time interval between layers on layer-interface strength were critically analyzed. In the context of additive manufacturing, the optimized composition C2, containing pozzolanic additives, exhibited mechanical performance superior to that of the mixture with Portland cement as the sole binder. In particular, Mixture C2 showed a less pronounced decrease in interface tensile strength. Even for time intervals between depositions of two layers as long as 1 day the loss in corresponding flexural strength was below 25%, as compared with C2 specimens tested in the perpendicular direction. In contrast, the decrease in flexural strength measured for C1 specimens amounted to over 90% for the same set of parameters. Higher porosity at the interfaces of the printed concrete layers was identified as the cause for the lower interface strengths of C1. Microscopic observations supported the findings of the macroscopic investigations. While a pronounced recovery (“self-healing”) of the porous, discontinuous interlayers was observed with increasing age for Mixture C2, in case of C1 the filling products grown in the porous interlayer were found to be non-strengthening.

Cold-water coral reefs are rich, yet fragile ecosystems found in colder oceanic waters. Knowledge of their spatial distribution on continental shelves, slopes, seamounts and ridge systems is vital for marine spatial planning and conservation. Cold-water corals frequently form conspicuous carbonate mounds of varying sizes, which are identifiable from multibeam echosounder bathymetry and derived geomorphometric attributes. However, the often large number of mounds makes manual interpretation and mapping a tedious process. We present a methodology that combines image segmentation and random forest spatial prediction with the aim to derive maps of carbonate mounds and an associated measure of confidence. We demonstrate our method based on multibeam echosounder data from Iverryggen on the mid-Norwegian shelf. We identified the image-object mean planar curvature as the most important predictor. The presence and absence of carbonate mounds is mapped with high accuracy (overall accuracy = 84.4%, sensitivity = 0.827 and specificity = 0.866). Spatially-explicit confidence in the predictions is derived from the predicted probability and whether the predictions are within or outside the modelled range of values and is generally high. We plan to apply the showcased method to other areas of the Norwegian continental shelf and slope where MBES data have been collected with the aim to provide crucial information for marine spatial planning.

Background: Globally, hot cooked refined rice is consumed in large quantities and is a major contributor to dietary glycaemic load. This study aimed to compare the glycaemic potency of hot and cold stored parboiled rice to widely available medium grain white rice. Method: Twenty-eight healthy volunteers participated in a three treatment experiment where postprandial blood glucose was measured over 120 minutes after consumption of 140g of rice. Three rice samples were freshly cooked medium-grain white rice, freshly cooked parboiled rice, and parboiled rice stored overnight at 4 ºC. All rice was served warm at 65 ºC. Chewing time was recorded. Results: The 24-hours cold-stored and reheated parboiled rice resulted in a 42% and 12% lower blood glucose concentration trajectory than freshly cooked medium-grain white rice and freshly cooked parboiled rice. Chewing time for 10g cold stored parboiled rice was 6 seconds (25%) longer and was considered more palatable, visually appealing and better tasting than freshly cooked medium grain (all P<0.05). Conclusions:. For regular consumers of rice reheating cooked rice after cold storage would lower the dietary glycaemic load and long term may reduce risk for type 2 and gestational diabetes. More trials are needed to identify the significance.

Cold plasma (CP) is an ionised gas containing excited molecules and ions, radicals, free electrons, and emits electric fields and UV radiation. CP is potently antimicrobial and can be applied safely to biological tissue, birthing the field of plasma medicine. Reactive oxygen and nitrogen species (RONS) produced by CP affect biological processes directly or indirectly via the modification of cellular lipids, proteins, DNA, and intracellular signalling pathways. CP can be applied at lower levels for oxidative eustress to activate cell proliferation, motility, migration, and antioxidant production in normal cells, mainly potentiated by the unfolded protein response, Nrf2-activated antioxidant response element and PI3K/Akt pathway, which also activates NFκB. At higher CP exposures, inactivation, apoptosis and autophagy of malignant cells can occur via degradation of PI3K/Akt and MAPK-dependent and -independent activation of the master tumour suppressor p53, leading to caspase-mediated cell death. These opposing responses validate a hormesis approach to plasma medicine. Clinical applications of CP are becoming increasingly realised in wound healing, while clinical effectiveness in tumours is currently coming to light. This review will outline advances in plasma medicine and compare the main redox and intracellular signalling responses to CP in wound healing and cancer.

Very heavy stratiform precipitation (> 200 mm/per day) occurred in the Hokitika region on the west coast of the South Island of New Zealand on 18 June 2015, under north-westerlies with small CAPE (< 25 J/kg). Analyses of model simulations and observations showed that this heavy rainfall was due to cold front lifting enhanced by orographic lifting over the Southern Alps. At 1.5 km grid-length, the model terrain underestimated the average height of the 103 tallest mountains over the South Island by ~ 800 m. This leads to weaker orographic lifting and mountain blocking, and a faster-moving and stronger cold front in the Hokitika region. As a result, large errors in the heavy rainfall prediction occur. By increasing either the resolved or the sub-grid mountain heights, the simulated rainfall errors were largely reduced through stronger orographic lifting and mountain blocking, and a better simulation of the cold front movement and strength. All the experiments have the same “flow-over” regime with mountain waves and/or wave breaking (Fm ranges 0.61 – 1.21). However, the rainfall amount and distribution on the windward side of mountains altered significantly. Our new findings were that the Southern Alps can have significant indirect effects on heavy rainfall by altering the speed and strength of the cold front, in addition to the well-known direct dynamical effects (i.e., orographic lifting and mountain blocking). A combination of these direct and indirect effects makes the heavy rainfall simulation sensitive to mountain heights even under the same “flow-over” regime.

Good hand hygiene has proven to be essential in reducing the uncontrolled spread of human pathogens. Cold atmospheric plasma (CAP) may provide an alternative to disinfecting hands with ethanol-based handrubs when hand washing facilities are unavailable. CAP can be safely applied to the skin if the energy is well controlled. In this study, RF and DC plasma sources was built with a pin-to-mesh electrodes configuration inside a fused silica tube of 5 mm of inner diameter. Microbiological assays based on EN 13697:2015+A1:2019 using Escherichia coli DSM 682 or Staphylococcus epidermidis DSM 20044 were used to examine the antimicrobial effect of various plasma conditions. Metal and silicone disks that model skin were used as inoculation matrices. The prototype air radio frequency (RF) CAP achieved significant disinfection in the MHz range on stainless steel and silicone substrates. This is equivalent to half the performance of direct current CAP, which is only effective on conductive substrates. Using only electricity and air CAP could, with further optimization, replace or complement current hand disinfection methods, and mitigate the economic burden of public health crises in the future.

Considering the significance of thermodynamic cycles in the global energy system, it is necessary to develop new general classes of thermodynamic cycles to relieve current energy and environmental problems. Inspired by the relationship between power cycles and refrigeration cycles, we realize that general classes of thermodynamic cycles should occur in pairs with opposite functions. Here we reverse class 1 heating cycles to obtain another new general class of thermodynamic cycles named class 2 heating cycles (HC-2s). HC-2s have two basic forms, and each contains six thermodynamic processes. HC-2s present the simplest and most general approach to utilizing the temperature difference between a medium-temperature heat source and a low-temperature heat sink to achieve efficient high-temperature heating. HC-2s fill the gaps that have existed since the origin of thermal science, and they will play significant roles in the global sustainable energy system.

Chromobacterium species are common in tropical and subtropical zones in environmental water samples and believed to «tropical» species. Here we describe an environmental case of resident Chromobacterium vaccinii in biofilms associated with Carex spp. roots in Moscow region, Russia (warm-summer humid continental climate zone). We performed broad characterization of individual properties as well as surrounding context for better understanding the premise of C. vaccinii survival during winter season. Genome properties of isolated strains propose some insights into adaptation to habit and biofilm mode of life, including social cheaters carrying ΔluxR mutation. Isolated C. vaccinii differs with previously described strains in some biochemical properties and some basic characteristics like fatty acid composition as well as unique genome features. Despite potential to modulate membrane fluidity and presence of several genes responsible for cold shock response, isolated C. vaccinii didn`t survive during exposure to 4 °C, while in initial complex biofilm it was able to survive for months in vitro at 4 °C. Surrounding bacterial community within the same biofilm with C. vaccinii represented a series of psychrophilic bacterial species which may share resistance to low temperatures with other species within biofilm and provide C. vaccinii opportunity to survive during cold winter season.

Plants have evolved tightly regulated strategies to adapt and acclimate to a changing environment to ensure their survival. Various environmental factors affect plant distribution, growth and yield. Low temperature belongs to those abiotic factors which significantly constrain range boundaries of plant species. Exposing plants to low but non-freezing temperature induces a multigenic processes termed cold acclimation, which finally results in an increased freezing tolerance. Cold acclimation comprises reprogramming of the transcriptome, proteome and metabolome and affects communication and signaling between subcellular organelles. Reprogramming of the central carbohydrate metabolism plays a key role in cold acclimation. This review summarizes current knowledge about the role of carbohydrate metabolism in plant cold acclimation. A focus is laid on subcellular metabolic reprogramming, its thermodynamic constraints under low temperature and mathematical modelling of metabolism.

Background: Delayed graft function (DGF) is common after kidney transplantation from de-ceased donor and may significantly affect post-transplant outcomes. This study aimed to evaluating whether an innovative approach, based on the administration of intravenous prostaglandin-analogue iloprost, could be beneficial in reducing the incidence of DGF occurring after kidney transplantation from deceased donors. Methods: This prospective, randomised (1:1), place-bo-controlled study enrolled all consecutive patients who received a kidney transplantation from a deceased donor from January 2000 to December 2012 and who were treated in the peri-transplant period with the prostaglandin-analogue iloprost at 0.27 μg/min through elastomeric pump (treatment group) or placebo (control group). Results: A total of 476 patients were included : DGF was reported in 172 (36.1%) patients in the entire cohort. The multivariate analysis showed that donor’s age > 70 years (OR 2.50, 95% Confidence Interval (CI) 1.40-3.05, p < .001), cold ischemia time > 24 h (OR 2.60, 95 CI 1.50-4.51, p < .001), donor’s AKI (OR 2.71, 95% CI 1.61-4.52, p = .021) and, above all, recipient’s arterial hypotension (OR 5.06, 95% CI 2.52-10.1, p < .0001) were the strongest risk factors for developing post-transplant DGF. The incidence of DGF was 21.4% in the treatment group and 50.9% in the control group (p< .001). Interestingly, among patients who developed DGF, those who received iloprost had a shorter duration of post-transplant DGF (10.58.3 v s13.46.7, days, p= .016). Conclusions: This study showed that the use of a continuous infusion of iloprost could safely and effectively reduce the incidence of DGF in recipients of deceased donor kidneys, allowing a better graft functionality as well as a better graft survival.

In this study, Plasma-Activated Water (PAW) was synthesized using a coaxial Dielectric Barrier Discharge (DBD) reactor, benefiting from the elevated capacity of air-flow-assisted DBD discharges to enhance nitrogen-based species concentration. By manipulating operational parameters, including gas flow rate, activation time, and DI water volume, we achieved significant concentrations of Reactive Oxygen and Nitrogen Species (RONS). As a result, the PAW obtained displayed pronounced physicochemical attributes: a pH of 2.06, an ORP of 275mV, conductivity of 3mS/cm, and TDS of 1200 mg/L. A pivotal aspect of this research was the evaluation of the reactor's efficiency, as indicated by metrics like the specific input energy and ozone efficiency yield. The antimicrobial potential of the PAW was also assessed against pathogenic microbes, with remarkable reductions in viability for both Staphylococcus aureus and Escherichia coli (99.99%) and a more moderate decrease for Candida albicans (37%). These findings underscore the capability of the coaxial DBD reactor in crafting high-quality PAW with significant antimicrobial properties, necessitating further studies to validate its broad-spectrum and safe application.

Ultra-large cold-water pipes (CWP) may present structural instability phenomenon under complex and variable operating conditions, and the current theoretical analysis rarely takes into account the influence of multiple key parameters at the same time, resulting in some errors between the prediction results and the actual deformation behavior of the pipe. Considering this issue, this paper establishes a computational analysis model of the mechanical performance of the CWP based on the Euler-Bernoulli beam theory, considering the effect of waves, the clump weight at the bottom, internal flow and sea current, and gives a time-dependent solution of the mechanical response of the pipe with the action of multiple key parameters using the differential quadrature method (DQM). Additionally, the correctness and validity of the theoretical model are well verified by comparing the numerical solution with the theoretical results. Finally, to study the effects of operating conditions on the mechanical response of the pipe, the effects of waves, the clump weight, internal flow and sea current on the lateral deflection and maximum bending moment of the pipeline are discussed based on numerical simulation and orthogonal experimental method. The results show that changing the wave strength and internal flow velocity has little effect on the lateral deflection of the CWP, and the clump weight at the bottom can effectively suppress the lateral deflection of the pipeline, but increasing the current velocity can significantly increase the lateral deflection of the pipeline, which can lead to the instability of the pipe. Nevertheless, the effects of waves, the clump weight, internal flow and sea current on the maximum bending moment of the pipeline are basically the same, all of them increase sharply at first, and then decrease gradually until they level off, and the differences in the effects are mainly reflected in the different locations of the pipe sections. This paper suggests the design guidance of CWP in aspect of dynamic response depending on the operating condition.

The human respiratory syncytial virus (hRSV) poses a serious risk to global public health and is a significant cause of severe lower respiratory infections. There are currently only a few therapies available to treat RSV infections, as well as no RSV vaccinations. Therefore, there is an urgent demand for clinically feasible, safe, and affordable RSV prevention and treatment alternatives. In this study, an ion-activated in situ gel comprising broad-spectrum antiviral 18β-glycyrrhetinic acid (GA) for antiviral action on RSV was developed. In this content, mechanical properties, sprayability, drug content, pH, ex vivo mucoadhesive strength, in vitro drug release pattern, and stability were all examined. Rheological properties were also tested by utilizing in vitro gelation capacity and rheological synergism tests. Finally, the optimized in situ gel's cytotoxic and antiviral activities on RSV cultured in human laryngeal epidermoid carcinoma (HEP-2) cell line were evaluated. In conclusion, the optimized in situ gel prepared with a combination of 0.5%w/w gellan gum and 0.5%w/w sodium carboxymethylcellulose demonstrated good gelation capacity and sprayability (weight deviation between T0 and T14: 0.34%), desired rheological synergism (mucoadhesive force (Fb): 9.53), mechanical characteristics (adhesiveness: 0.300 mJ ± 0.05), ex vivo bioadhesion force (19.67 g ± 1.90), drug content uniformity (RSD%: 0.494), and sustained drug release over period of 168 h (101.57% ± 0.53). The antiviral activity test results showed that the optimized in situ gel had strong anti-HRSV activity (EC50 simultaneous = 0.05 µg/ml, SI = 306; EC50 preinfection = 0.154 µg/ml, SI= 100) which was significantly higher than that of ribavirin (EC50 =4.189 µg/ml; SI= 28) used as a positive control against hRSV. In conclusion, this research has demonstrated the formulation of an effective antiviral nasal spray that has the ability to possess both prophylactic and virucidal activity.

The IgM and IgT classes were previously identified and characterized in the Antarctic teleost Trematomus bernacchii, a species belonging to the Perciform suborder Notothenoidei. Herein we characterized the gene encoding the polymeric immunoglobulin receptor (pIgR) in the same species and compared it to pIgR of multiple teleost species belonging to five perciform sub-orders, including 11 Antarctic and one non-Antarctic (Cottoperca gobio) notothenioid species, the latter living in less cold periantarctic sea. Antarctic pIgR genes displayed particularly long in-trons marked by sites of transposable elements and transcription factors. Furthermore, analysis of T. bernacchii pIgR cDNA unveiled multiple amino acid substitutions unique to Antarctic species, all introducing adaptive features, including N-glycosylation sequons. Interestingly, C. gobio shared most features with the other perciforms rather than with the cold adapted relatives. T. bernacchii pIgR transcripts were predominantly expressed in mucosal tissues, as indicated by q-PCR and in situ hybridization analysis. These results suggest that in cold adapted species pIgR preserved its fundamental role in mucosal immune defense, although remarkable gene structure modifications occurred.

Miniaturization of electronics devices is often limited by the concomitant high heat fluxes (cooling load) and maldistribution of temperature profiles (hot spots). Thermal energy storage (TES) platforms providing supplemental cooling can be a cost-effective solution, that often leverages phase change materials (PCM). Although salt hydrates provide higher storage capacities and power ratings (as compared to that of the organic PCMs), they suffer from reliability issues (e.g., supercooling). ‘Cold Finger Technique (CFT)’ can obviate supercooling by maintaining a small mass fraction of the PCM in solid state for enabling spontaneous nucleation. Optimization of CFT necessitates real-time forecasting of the transient values of the melt-fraction. In this study artificial neural network (ANN) is explored for real-time prediction of the time remaining to reach a target value of melt-fraction based on the prior history of the spatial distribution of the surface temperature transients. Two different approaches were explored for training the ANN model, using: (1) transient PCM-temperature data; or (2) transient surface-temperature data. When deployed in a heat sink that leverages PCM based passive thermal management systems for cooling of electronic chips and packages, this maverick approach (using the second method) affords cheaper costs, better sustainability, higher reliability and resilience.

The tribological performance of metalwork steel tools is of vital importance in both cold and hot working processes. One solution for improving metal tool life is the application of coatings. This paper investigates the effect of CrAlSiN thin-film PVD-deposition on the tribological behaviour of tool steel K340. The sliding wear performance of the coated K340 steel is analysed in relation to both the uncoated K340 steel and a range of tool steels dedicated to hot- and cold-working, such as X155CrVMo12-1, X37CrMoV5-1, X40CrMoV5-1, 40CrMnMo7 and 90MnCrV8. The investigated tool steels were heat-treated, while K340 was subjected to thermochemical treatment and then coated with a CrAlSiN hard film (K340/CrAlSiN). The hardness, chemical composition, phase structure and microstructure of steels K340 and K340/CrAlSiN are examined. Tribological tests were conducted using the ball-on-disc tester in compliance with the ASTM G99 standard. The tests were performed under dry unidirectional sliding conditions, using an Al2O3 ball as a counterbody. The wear factor and coefficient of friction are estimated and analysed with respect to hardness and alloying composition of the materials under study. SEM observations are made to identify the sliding wear mechanisms of the analysed tool steels and PVD-coated K340 steel. In contrast to the harsh abrasive-adhesive wear mechanism observed for uncoated tool steels, the abrasive wear dominates in case of the AlCrSiN. The deposited thin film effectively prevents the K304 substrate from harsh wear severe degradation. Moreover, thanks to the deposited coating, the K304/CrAlSiN sample has a COF of 0.529 and a wear factor of K=5.68×10−7 m3 N−1 m−1, while the COF of the reference tool steels ranges from 0.702 to 0.885 and their wear factor ranges from 1.68×10−5 m3 N−1 m−1 to 3.67×10−5 m3 N−1 m−1. The CrAlSiN deposition reduces the wear of the K340 steel and improves its sliding properties, which makes it a promising method for prolonging the service life of metalwork tools.

A new lateral force-resisting wall panel is presented for applications in mid-rise prefabricated lightweight steel construction in seismic prone regions. This panelised system is composed of a hot-rolled frame and cold-formed studs and tracks, which works as a lateral force resisting system in lightweight steel framing. The proposed hybrid panel system exhibits proper ductility and energy dissipation behaviour. The hysteretic responses of full-scale panel experiments demonstrate that the system can safely resist high cyclic loads. The hot-rolled steel part, on the other hand, can significantly improve the initial lateral stiffness of the total system that will control the maximum allowable drift of multi-story buildings. Finally, in a case study, by applying the proposed system to the design of a mid-rise building in a high seismic area, the performance of the hybrid panels, are compared with those of fully hot-rolled systems (moment resisting frames) and fully cold formed systems. The findings indicate that applying hybrid panels will result in lower weights and better performance in seismic prone regions.

Obesity-associated metabolic abnormalities comprise of a cluster of conditions including dyslipidemia, insulin resistance, diabetes, and cardiovascular diseases that has affected more than 650 million people all over the globe. Obesity results from accumulation of white adipose tissues mainly due to the chronic imbalance of energy intake and energy expenditure. Variety of approaches to treat or prevent obesity, including lifestyle interventions, surgical weight loss procedures and pharmacological approaches to reduce energy intake and increase energy expenditure have failed to substantially decrease the prevalence of obesity. Brown adipose tissue (BAT), the primary source of thermogenesis in infants and small mammals may represent a promising therapeutic target to treat obesity by promoting energy expenditure through non-shivering thermogenesis mediated by mitochondrial uncoupling protein 1 (UCP1). Since the confirmation of functional BAT in adult humans by several groups, approximately a decade ago and its association with a favorable metabolic phenotype, intense interest on the significance of BAT in adult human physiology and metabolic health has emerged within the scientific community to explore its therapeutic potential for the treatment of obesity and metabolic diseases. Substantially decreased BAT activity in individuals with obesity indicates a role for BAT in setting of human obesity. On the other hand, BAT mass and its prevalence has been reported to correlate with lower body mass index (BMI), decreased age and glucose levels, leading to lower incidence of cardio metabolic diseases. Increased cold exposure in adult humans with undetectable BAT was associated with decreased body fat mass and increased insulin sensitivity. Deeper understanding of the role of BAT in human metabolic health and its inter-relationship with body fat distribution and deciphering proper strategies to increase energy expenditure by either increasing functional BAT mass, or inducing white adipose browning holds the promise for possible therapeutic avenues for the treatment of obesity and associated metabolic disorders.

To understand great disparities in disease outcomes between CIVID-19 patients, we explore infection and host responses in kinetics. From existing data, we deduced a model that the lungs are damaged by rapidly rising flow resistance as a result of retaining white blood cells in lung tissues. The retention of white blood cells is initially triggered by viral infection but aggravated by injuries caused by low temperature. Lungs are initially damaged by fluid leakage, rapidly followed by extruding blood into alveolar spaces. The step of blood extruding is predicted to take place in a very short time. Our simulations show that as little as 0.1% retention of white blood cells in the lungs can lead to their failure in 5 to 10 days. The small degrees of imbalance implies that this imbalance could be corrected by a large number of factors that are known to reduce flow resistance. The model implies that the top priority is maintaining blood micro-circulation and preserving organ functions in the entire disease course, especially after the virus has spread the whole lungs. From exploring a large number of hypothetical infection modes, we propose preventive, mitigating and treatment strategies for ultimately ending the pandemic. The first strategy is avoiding exposures that could result in widespread damages to lungs and taking post exposure mitigating measures that would reduce disease severity. The second strategy is reducing death rate and disability rate from the current levels to one tenth for infected patients by using multiple factors health optimization method. The double reduction strategies are expected to generate a series of chain reactions that favor mitigating or ending the pandemic. Some reactions include a big reduction of the amount of viral discharges from infected patients into the air, the avoidance of panic, chronic stress and emotional distress, and cross-infections which are expected in quarantines. The double reductions would have a final effect of ending the pandemic.

We conducted many model simulations to understand the causes of the damages of coronavirus to lung tissues and constructed a diagram showing viral development, immune response and damage accumulation curves. We found that main causes are (1) the phase lag between the viral reproduction process and a belayed immune response, (2) the direct viral damages and massive collateral damages which are mainly caused by belated immune responses, and (3) further tissue damages triggered by accumulated wastes in lungs. We deduced from those causes that the key strategies for preventing lung damages include avoiding direct lung infection, altering host-virus interactions, promoting immune responses, diluting virus concentrations in lung tissues by promoting viral migration to the rest of the body, maintaining waste removal balance, protecting heart function and renal function, avoiding other infections, reducing allergic reactions and other inflammation, etc. We finally discussed how to use dietary, medical, emotional, lifestyle, environmental, mechanical factors, etc. to alter disease outcomes. We show why true benefits of those factors cannot be determined by randomized controlled trials, and why the multiple-factor optimization approach can be highly effective by examining organ usable capacity in the cause of death. This treatment protocol using water, air, salt, sound, temperature, emotion, exercise, etc. can be the most powerful cures for viral and non-viral lung infections because they do not depend on molecular specificity and are freely available to anyone.

The production of particles outside the region of nucleon-nucleon kinematics due to interactions involving dense cold clusters of quark-gluon matter in nuclei is calculated. The possibility of observing this process in the region of central rapidities and large transverse momenta in heavy ion collisions at low energies with MPD detector at the NICA collider has been demonstrated.

We reviewed various physical and biological manifestations of an unprecedented large-scale water temperature anomaly that emerged in the Northeast Pacific in late 2013. The anomaly dubbed “The Blob” persisted through 2014-2016, with some signs of its persistence through 2017-2018 and a possible reemergence in 2019. The tentative timeline of The Blob’s successive appearances around the Northeast Pacific is suggestive of its advection by currents around the Gulf of Alaska, along the Aleutians, into the Bering Sea, and eventually to the Bering Strait. During the initial phase of The Blob’s development in 2013-2014, advection along the Polar Front might have played a certain role. The extreme persistence and magnitude of The Blob resulted in numerous and sometimes dramatic ecosystem responses in the eastern Bering Sea. The multi-year duration of The Blob might have preconditioned the Bering Sea for the record low seasonal sea ice extent during the winter of 2017-2018 and disappearance of the cold pool in 2016 and 2018 that profoundly affected zooplankton, invertebrates, fishes, sea birds, and marine mammals. Comparison of time-series of population responses across trophic levels suggests that The Blob lowered primary production during spring, increasing small copepod production and jellyfish, and reducing energy transfer efficiently to higher trophic levels. While the Bering Sea’s water temperature, seasonal sea ice, and cold pool seem to return to the long-term mean state in 2022, it remains to be seen if the Bering Sea ecosystem will completely recover. The two most likely alternative scenarios envision either irreversible changes or hysteresis recovery.

Advanced ceramics are recognized as key enabling materials possessing combinations of properties not achievable in other material classes. They are characterized by very high thermal, chemical and mechanical resistance and also usually have a lower density than metals. These properties predestine ceramics for many different applications, especially space applications.In the aerospace sector aerospike nozzles promise performance and application advantages compared to classic bell nozzles but are also inherently more complex to manufacture due to their shape. AM methods drastically simplify or even enable the fabrication of those complex structures while minimising the number of individual parts. The applicability of ceramic AM (“CerAMfacturing”) on rocket engines and especially nozzles is consequently investigated in the frame of the “MACARONIS” project, a cooperation of the Institute of Aerospace Engineering at Technische Universität Dresden and the Fraunhofer Institute for Ceramic Technologies and Systems (IKTS) in Dresden. The goal is to develop novel large size aerospike thrust nozzles including areas of highest resolution and fineness. Finding a suitable AM process that enables the realisation of both aspects is extremely challenging. One possibility could be the hybridization of shaping methods, in that case CerAM VPP (ceramic additive manufacturing via vat photopolymerization) and CerAM FFF (ceramic additive manufacturing via fused filament fabrication) in combination with sinter joining. This contribution focuses on the high resolution CerAM VPP process, in particular the development, characterization and testing of a new photoreactive Al₂O₃ suspension validated by AM of novel aerospike nozzles.

The structure and phenomena arising from charge transfer in cold field emission modus in a single closed carbon nanotube under cold field emission conditions were studied. By studying microphotographs in various microscopes - AFM, SEM, TEM it was found inhomogeneities in the form of two types of superlattices. The conductivity of the emitter section of a nanodiode circuit with an emitter made of an individual closed carbon nanotube (CNT) and arrays of closed CNTs was studied. High values of cold field emission were observed, as well as nonlinearity and anomalies of the current-voltage characteristic (I-V characteristics), which manifested themselves in the form of peaks at low and high current values. Peaks in the CVC have distinct areas of negative differential conductivity. It is argued, that the anomalously high currents in the I–V characteristics of cold field emission of electrons from a nanoemitter made of closed CNTs can be associated with a sharp increase in the density of electron states at energies near the van Hove singularity.

Despite significant advances in metallurgy and the potential to create high and very high-strength steel, all international specifications for steel design provided little information about the limits of slenderness for high-strength steel sections (HSSs) and didn’t give anything about the design of very high-strength steel sections (VHSSs). The American structural steel design specification covers circular hollow sections (CHS) of steel grades up to S690, while it isn't in ANSI/AISC 360-16 and ASTM A514/A514M. Euro code EN 1993-1-1 can be applicable only to steel grades up to S460. EN 1993-1-3 and EN 1993-1-12 contain supplementary rules for cold-formed members and HSS (S460- S700), respectively. Though ductility requirements for (HSS) are specifically established in EN 1993-1-12, it is largely a continuation of the normal-strength-steel design procedures standardized in EN 1993-1-1, where (HSSs) are largely treated as normal-strength steels in these rules, and the same design approaches are used. The behavior of high and very high-strength steel circular hollow sections under axial compression load is studied in this research. A total of 16 nonlinear finite-element (FE) models were generated to replicate stub column tests that were experimentally tested by others in previous research. Hence, a parametric study is conducted using forty FE models developed to investigate the local buckling behavior under various slenderness ratios comprehensively. The developed models cover slenderness ratios ranging from 20 to 1226 and steel grades S460 and S1100 with yield stress equal 460 MPa and 1152 MPa, respectively. The FE results were combined with 105 previously collected experimental results to assess the applicability of existing codified design methodologies in the Euro code and the North American codes of cold-formed CHS. Based on the results of this study, new cross-sectional slenderness limits and new design equations for more efficient simple designs were presented for high and very-high strength steel circular hollow sections and Compared with the results of experimental tests and FE models.