Sort by
Connecting Meteorite Spectra to Lunar Surface Composition Using Hyperspectral Imaging and Machine Learning
Fatemeh Fazel Hesar
,Mojtaba Raouf
,Amirmohammad Chegeni
,Peyman Soltani
,Bernard Foing
,Elias Chatzitheodoridis
,Michiel J.A. de Dood
,Fons J. Verbeek
Posted: 17 March 2026
ML-Driven In Vitro Remodeling of Alveolar Macrophage Profiles from Bronchoalveolar Lavage Fluid: A Novel Approach for Personalized Therapy in Severe Respiratory Diseases
ML-Driven In Vitro Remodeling of Alveolar Macrophage Profiles from Bronchoalveolar Lavage Fluid: A Novel Approach for Personalized Therapy in Severe Respiratory Diseases
Igor D. Zlotnikov
,Alexander A. Vinogradov
,Elena V. Kudryashova
The secondary immunomodulatory effects of conventional therapeutics, such as antibiotics and cytostatics, are frequently overlooked despite their significant clinical implications. Building on our previous findings that drugs like paclitaxel and doxorubicin heavily influence macrophage polarization—potentially driving metastasis or inflammation—this study systematically evaluates the secondary immune-modulating actions of standard drugs and natural adjuvants. Using patient-derived bronchoalveolar lavage (BAL) fluid (ex vivo alveolar macrophages), we developed an analytical platform using synthetic carbohydrate-functionalized fluorescent ligands targeting key receptors (CD206, CD209, CD280, CD301). Integrating ligand-binding profiles with Linear Discriminant Analysis (LDA) yielded quantitative immune-state vectors capable of differentiating between favorable prognostic signatures and imbalanced immune states. Profiling samples across heterogeneous respiratory conditions revealed highly context-dependent responses. While some treatments synergistically corrected imbalanced profiles, others provoked dysregulation. Notably, in pneumonia or bronchitis with an asthma-prone M2-dominant profile, specific antibiotic regimens are critical; doxycycline, for instance, may exacerbate patient deterioration by further driving M2a polarization. Crucially, we identified that natural adjuvants (e.g., curcumin, coumarins, polyphenols) exhibit potent properties capable of correcting these adverse secondary drug effects. Ultimately, this profiling platform highlights the necessity of evaluating patient-specific secondary drug effects, offering a functional blueprint for precision immunotherapy and the rational design of adjuvant-enhanced treatments.
The secondary immunomodulatory effects of conventional therapeutics, such as antibiotics and cytostatics, are frequently overlooked despite their significant clinical implications. Building on our previous findings that drugs like paclitaxel and doxorubicin heavily influence macrophage polarization—potentially driving metastasis or inflammation—this study systematically evaluates the secondary immune-modulating actions of standard drugs and natural adjuvants. Using patient-derived bronchoalveolar lavage (BAL) fluid (ex vivo alveolar macrophages), we developed an analytical platform using synthetic carbohydrate-functionalized fluorescent ligands targeting key receptors (CD206, CD209, CD280, CD301). Integrating ligand-binding profiles with Linear Discriminant Analysis (LDA) yielded quantitative immune-state vectors capable of differentiating between favorable prognostic signatures and imbalanced immune states. Profiling samples across heterogeneous respiratory conditions revealed highly context-dependent responses. While some treatments synergistically corrected imbalanced profiles, others provoked dysregulation. Notably, in pneumonia or bronchitis with an asthma-prone M2-dominant profile, specific antibiotic regimens are critical; doxycycline, for instance, may exacerbate patient deterioration by further driving M2a polarization. Crucially, we identified that natural adjuvants (e.g., curcumin, coumarins, polyphenols) exhibit potent properties capable of correcting these adverse secondary drug effects. Ultimately, this profiling platform highlights the necessity of evaluating patient-specific secondary drug effects, offering a functional blueprint for precision immunotherapy and the rational design of adjuvant-enhanced treatments.
Posted: 17 March 2026
Compassion-Based Charity Care as a Model for Health Equity: A Qualitative Case Study from a Tertiary Hospital in Indonesia
Andri Hondir
,Ferdi Antonio
,Natalin Allorerung
,Suriadi Huang
Posted: 17 March 2026
Dispiroindolinone-Glutarimide Conjugates as Potential Hetero-PROTAC Compounds for p53 Reactivation
Vladislav S. Polyakov
,Yuri K. Grishin
,Ekaterina S. Ivanova
,Alexander A. Shtil
,Elena K. Beloglazkina
Aiming at p53-reactivating compounds, a convergent scheme for the preparation of conjugates with the dispiro-indolinone-pyrrolidine-thioimidazolone and glutarimide moieties connected via a triazole-containing linker were proposed. Target conjugates were synthesized by azide-alkyne cycloaddition reactions between propargylthio-substituted dispiro-indolinone-pyrrolidine-imidazolones and an azido-glutarimide derivative. The starting compounds were available isothiocyanates, glycine, substituted benzaldehydes, chloroacetamide, and ethyl acrylate. The key azide-alkyne cycloaddition step was carried out using TBTA as a catalyst, achieving >70% product yields. The resulting bifunctional compounds contained a fragment of dispiroindolinone (p53-MDM2 interaction inhibitor) and glutarimide, an ubiquitin ligase ligand. The dispiroindolinone-glutarimide conjugate with 5-bromoisatine and 4-bromophenyl moieties showed a potential for p53 re-activation as determined by preferential cytotoxicity against HCT116 colon carcinoma cells (wild type53) compared to the isogenic HCT116p53-/- subline.
Aiming at p53-reactivating compounds, a convergent scheme for the preparation of conjugates with the dispiro-indolinone-pyrrolidine-thioimidazolone and glutarimide moieties connected via a triazole-containing linker were proposed. Target conjugates were synthesized by azide-alkyne cycloaddition reactions between propargylthio-substituted dispiro-indolinone-pyrrolidine-imidazolones and an azido-glutarimide derivative. The starting compounds were available isothiocyanates, glycine, substituted benzaldehydes, chloroacetamide, and ethyl acrylate. The key azide-alkyne cycloaddition step was carried out using TBTA as a catalyst, achieving >70% product yields. The resulting bifunctional compounds contained a fragment of dispiroindolinone (p53-MDM2 interaction inhibitor) and glutarimide, an ubiquitin ligase ligand. The dispiroindolinone-glutarimide conjugate with 5-bromoisatine and 4-bromophenyl moieties showed a potential for p53 re-activation as determined by preferential cytotoxicity against HCT116 colon carcinoma cells (wild type53) compared to the isogenic HCT116p53-/- subline.
Posted: 17 March 2026
Activity of Low Dose Nivolumab in Patients with Advanced Squamous Cell Carcinomas and Other Cancers
Thibault Gauduchon
,Jérôme Fayette
,Mona Amini-Adle
,Eve-Marie Neidhart-Berard
,Mehdi Brahmi
,Armelle Dufresne
,Margaux Dupont
,Clelia Coutzac
,Axel De Bernardi
,Philippe Toussaint
+7 authors
Posted: 17 March 2026
HPST: A Hybrid Physics-Spectral-Threshold Framework for Fluid Flow Analysis with Theorem Proving and Graph Neural Networks
Mohsen Mostafa
Posted: 17 March 2026
Biopolymer Composite Films with Naringin for Wound Healing Applications
Gulzeynep Begimova
,Aishat Kuldanova
,Irina Kuxina
,Nazira Chinibekova
Posted: 17 March 2026
Bleb Compressive Sutures for Eyes with Filtering Bleb Following Trabeculectomy in Descemet Stripping Automated Endothelial Keratoplasty
Noriko Toyokawa
,Kaoru Araki-Sasaki
,Hideya Kimura
,Shinichiro Kuroda
Posted: 17 March 2026
Schrödinger-Dirac Formalism in Finite Ring Continuum
Yosef Akhtman
Posted: 17 March 2026
Edge AI Conversion Modelling Optimizing TOFU-to-BOFU Dynamics for Intent-Based Digital Marketing Revenue Acceleration
R Karthick
Posted: 17 March 2026
A Novel Hybrid Quantum Circuit for Integer Factorization: End-to-End Evaluation in Simulation and Real Quantum Hardware
Jesse Van Griensven
,Victor Oliveira Santos
,Bahram Gharabaghi
Posted: 17 March 2026
Uncertainty-Aware Marketing Attribution Inference and Budget Decision-Making with Intelligent Agents
Qianxi Liu
,Ye Zhang
,Sheng Chen
,Zhaocheng Liu
,Yuqiu Xu
,Hengguang Cui
Posted: 17 March 2026
Wearables for Telemonitoring in ATTR-Amyloidosis: Current Perspectives
Andreas Kind
,Helena Pernice
,Gina Barzen
,Jan Gröschel
,Aurelian Eroni Schumacher
,Stefanie Werhahn
,Paul Julius Wetzel
,Frank Edelmann
,Gerhard Hindricks
,Katrin Hahn
+1 authors
Posted: 17 March 2026
From Gastric Mucosa to Brain: Neurological Dimensions of Helicobacter pylori Infection
Maria Pina Dore
,Giuseppe Lasaracina
,Giovanni Mario Pes
,Paolo Solla
,Elettra Merola
Posted: 17 March 2026
Hydrochemical Typology of Natural Lakes in the Polissia Region Based on Self-Organizing Maps: Implications for Sustainable Water Resources Management
Olha Biedunkova
,Pavlo Kuznietsov
,Oksana Tsos
,Olha Karaim
Posted: 17 March 2026
Comparative Effects of Glycine max and Glycine soja Leaves on Clanis bilineata tsingtauica Rearing Performance
Ping Zhao
,Chen Meng
,Syeda Wajeeha Gillani
,Xueli Lu
,Xi Jia
,Meng Wang
,Yu Bai
,Yiru Song
,Hongyan Hou
,Yiqiang Li
+2 authors
Posted: 17 March 2026
The Dual-Axiom Fixed Point: Universal Computational Cost and the Deduction of the Physical Hardware
Igor Durdanovic
Posted: 17 March 2026
Redefining Linguistics: The Law of the Trio as a Universal Framework in Dialogue with Major Theories
Tedros Kifle Tesfa
Posted: 17 March 2026
A Metal Importer and Exporter Interact Differently in the Chloroplast and Cell Membrane
Karnelia Paul
,Biswajit Ray
,Chinmay Saha
,Anupam Roy
,Sohini Basu
,Anindita Seal
Posted: 17 March 2026
The Onset of the Relativistic Ruler: Metric Emergence and the Pre-Relativistic Boundary of the GERT Universe
Veronica Padilha Dutra
Posted: 17 March 2026
of 5,685