The literature indicates that the qubit requirements for factoring RSA-2048 remain on the order of 1 million, under commonly assumed architectures and error-correction models, leaving a substantial gap between current resource estimates and near-term practical feasibility. Reducing this requirement to the low-thousands-qubit regime therefore remains an important open research objective. This work proposes a hybrid classical-quantum algorithm that uses a classical modular exponentiation subroutine with a Quantum Number Theoretic Transform (QNTT) circuit to increase the speed and reduce the required quantum resources relative to Shor’s algorithm for integer factorization, which underpins cryptographic systems like RSA and ECC. We evaluate multiple coprime numbers, the result of multiplication of two primes, in both simulation and real quantum hardware, using IBM’s reference Shor implementation as the baseline. Because Shor and proposed Jesse–Victor–Gharabaghi (JVG) use different register sizes for the same coprime N, the reported gate/depth reductions should be interpreted as end-to-end quantum-resource budgets for factoring the same N, rather than a per-qubit or transform-only efficiency claim. In simulation, the JVG algorithm achieved substantial practical reductions in computational resources, decreasing runtime from 174.1 s to 5.4 s, memory usage from 12.5 GB to 0.27 GB, and quantum gate counts by approximately 99%. On quantum hardware, JVG reduced the required runtime from 67.8 s to 2 s, and the quantum gate counts by over 98%. We showed that the proposed algorithm can address RSA-1024 relevant case scenario, establishing that this method can provide validation for large-scale situations. Furthermore, extrapolation to RSA-2048 indicates that the JVG algorithm significantly outperforms Shor’s approach, requiring a projected quantum runtime of 29 hours for ten thousand runs for factorization under identical scaling assumptions. Overall, these results support JVG as a more hardware-compatible and robust noise-tolerant substitute for Shor’s framework, offering a viable research direction toward practical quantum integer factorization on near-term Noisy Intermediate-Scale Quantum (NISQ) devices.