This paper is based on the concept of absolute airspace and its local absolute stationary reference system proposed by the author, on the premise of abandoning space concept and the relativity principle of relativity theory, It is proposed that general relativity and special relativity can be unified into Simple and practical a space-time transformation theory which fully includes other basic physical principles of relativity. And the unified and simple expression of the time transformation effect is proved and deduced. By comparing with the theoretical derivation and checking calculation of Hafele-Keating experiment in an ideal state, It is proved that the expression of time transformation effect proposed in this paper is completely correct. Compared with the theory of relativity, the calculation is simpler and more accurate. The paper also puts forward two checking prediction of physical cases about the time transformation effect, which are left for the capable competent unit or individual to verify in practice.

Through a brief analysis of the basic principle of relativity, it is found that there is a contradiction in principle between general relativity and special relativity in solving the specific problem of the clock moving around the earth, and one of them must be wrong. Through comparative analysis of five physical phenomena and experiments, it is proved that there are serious problems in the space concept of relativity theory and classical physic. At the same time, the different concept of absolute airspace is further expounded and demonstrated, and the related space-time physical phenomena and experiments are perfectly explained by this concept. According to this idea, a new time transformation relation is deduced and its correctness is demonstrated. It is proved that the principle of special relativity and special relativity are wrong, and a series of physical laws and physical explanations generated by special relativity may also be wrong, and a series of amendments or new interpretations need to be made.

The absolute time and relative time are defined in terms of the 4-D Euclidean space. Our universe is the 3-D x₁x₂x₃ quantized photon space which follows the absolute time simultaneity when the universe moves along the absolute time axis of ct. The length expansion of Dx = gDx₀ is derived under the condition of the absolute time (ct) simultaneity. From the similarity between this length expansion of Dx = gDx₀ and the energy increasing of E = gE₀, it is assumed that the energy is proportional to the particle size of Dx. The extension of this assumption to the 4-D Euclidean space gives the new definition that the particle energy (E) is the 4-D volume. Then, the particle mass energy is defined as E= mc² = cDtDV = gE₀. The masses of the elementary particles are originated from the 4-D warped volume of the photon space because the particle is the warped photon space with the velocity of v < c. Therefore, the Higgs boson concept in the standard model (SM) is not needed in the present 3-D quantized space model (TQSM). The scalar boson with the spin of zero, photon with the spin of 1 and graviton with the spin of 2 are the two-boson states. Therefore, the observed Higgs boson is reinterpreted as the two-boson state of the scalar boson with the spin of zero. The cosmic muon observation and twin paradox are explained by using the absolute time and relative time. The relative time is the observed time in the twin paradox and cosmic muon observation. In the twin paradox, a person who travels the long distance is more aged than a person on the earth in terms of the relative time ages because of the space and time conversion effect (STCE effect) of the moving space distance (x). But twins are in the same ages in terms of the absolute time without STCE effect. The fast-moving cosmic muon has the expanded half-life from the time expansion of the relative time. Also, the quantum entanglement and Pauli exclusion principle are explained. The quantum base of the photon space line connects two entangled particles. Two particles and quantum base system is fluctuated along the absolute time axis by the time clicking when one particle is measured. Another particle is instantly selected by the time clicking. This is called as the quantum entanglement. The photons which are the flat photon space with the constant speed of c along the space axis and absolute time axis have the 4-D photon velocity of c_eff = 2^0.5 c. Total 10-D Euclidean space including three 3-D quantized spaces and one absolute time axis is required for the electric charges (EC), lepton charges (CC) and color charges (CC) of the elementary particles. The 3-D photon space is very stiff along the absolute time (ct) axis and very soft along the space axes. The Coulomb force through the photons (2EM waves) of the space fluctuations is much stronger than the Gravitational force through the gravitons (G waves) of the time fluctuations between two electrons.

The paper suggests that the physical priciple of special relativity's space-time transformation effect is wrong, Uniform linear motion without acceleration does not exist objectively, nor does its same reference frames. Therefore, it is inferred that the space-time transformation effect of special relativity is caused by the acceleration of moving objects, special relativity is only a part of general relativity, not a theoretical system that exists independently from general relativity. The corresponding mathematical demonstration and calculation verification are carried out, and the result proves that the inference of the paper is correct. At the same time, it further explains that the concept of absolute airspace is correct. Special relativity has serious errors in the concept of space, the principle of relativity and the physical principle of space-time transformation effect. Therefore, it is necessary to make a series of revisions to the theory of relativity and to reinterpret some related physical problems.

In this paper, an analytical form of Rump Function is presented. This seminal function constitutes a fundamental concept of digital signal processing theory and is also involved in many other areas of applied mathematics. In particular, Rump Function is performed in a simple manner as the limit of a sequence of real functions letting ? tend to infinity. This limit is zero for strictly negative values of the real variable ? whereas it coincides with the independent variable ? for strictly positive values of the variable ?. The novelty of this work compared to other research studies concerning analytical expressions of the Ramp Function, is that the proposed formula is not exhibited in terms of miscellaneous special functions, e.g. Gamma Function, Biexponential Function or any other special functions such as Error Function, Hyperbolic Function, Orthogonal polynomials etc. Hence, this formula may be much more practical, flexible and useful in the computational procedures which are inserted into digital signal processing techniques and other engineering practices.

A linear stability analysis of the parallel uniform flow in a horizontal channel with open upper boundary is carried out. The lower boundary is considered as an impermeable isothermal wall, while the open upper boundary is subject to a uniform heat flux and it is exposed to an external horizontal fluid stream driving the flow. An eigenvalue problem is obtained for the two-dimensional transverse modes of perturbation. The study of the analytical dispersion relation leads to the conditions for the onset of convective instability as well as to the determination of the parametric threshold for the transition to absolute instability. The results are generalised to the case of three-dimensional perturbations.

The thesis proposes a argument that a mass point moving in a horizontal circle on the Earth’s surface can generate a radial centrifugal force of the Earth’s center of mass, thus realizing an unconventional anti-gravity path. Based on the author’s theory of absolute airspace and its reference system, and through the theoretical analysis of the difference in the distribution of gravitational acceleration at different latitudes caused by the rotation of the earth, and the centrifugal force of a mass point moving in a horizontal circle on the earth’s surface is analyzed, the validity of the argument is demonstrated. At the same time, the paper puts forward two possible basic principles, and makes theoretical analysis and demonstration. Conceive of the concrete experimental verification of principle two is proposed. Four technical schemes for anti-gravity ascent are proposed and basic analysis is made. On the premise of not fully considering the practical technical ability, it is theoretically proved that three of them have realistic operability and development potential. In theory, this paper opens up a different way of anti-gravity for human beings, which will bring new ideas and prospects for human beings to get rid of the bondage of gravity.

Abstract: Nordic exercises aim to improve physical abilities and prevent injuries; However, it is not clear in what type of sports modalities to use it, so this study arises from the interest of ana-lyzing its effect in different sports modalities. Objective: To analyze Nordic exercises effects on the lower limbs, and their relationship with the explosive and absolute strength inherent to demands of different sports modalities (football, athletics, basketball, sport climbing, cycling and taekwondo). Method: quasi-experimental research, identifying 122 athletes (18±3 years old) from: football (n=24), athletics/speed (n=20), sport climbing (n=20), basketball (n=24), taekwondo (n=14) and cycling (n=20); classified into a control group CG (n=57) and an experimental group EG (n=65). Results: dominant absolute strength of the initial (12.4±0.51) and final (14.5±0.98) EG, in greater proportion in basketball (P= < 0.05); explosive strength of the initial (42.4±1.2) and final (45.8±1.5) EG, with a significant difference in all modalities between before and after (p≤0.05), except in cy-cling and taekwondo; no major changes were found in the GC. Conclusion: Nordic exercises are recommended as part of training to improve levels of explosive strength with emphasis on the modalities of football, basketball, athletics/speed and sport climbing, being applicable to increase absolute strength in basketball.

In this paper, the Hafele‐Keating experiment and the geostationary orbit satellite of related physics problems of are analyzed and discussed in detail. If researchers read the paper and think about it, It will be found that the Hafele‐Keating experiment and the geostationary satellite problem prove that some of the core ideas and theories of relativity are seriously wrong. Isnʹt that a very serious problem in physics? Canʹt this cause the academic circles to pay great attention to it? Isnʹt this worthy of in‐depth analysis and research? The core of the paper is to point out that there are problems with the space concept and the reference system theory of classical physics and relativity, And that would bring up a whole host of physics problems. It takes a concerted effort from the academic community, Do furtherin‐depth analysis and research. Strive forthe further discovery and perfection of physics theory.

The samples from lunar farside have great significance for the study of the Moon, and even the solar system. Chang’e-6 landed successfully on the southern mare of the Apollo basin and returned ~2 kg samples from lunar farside. To provide a better understanding for the background of the returned samples, we conducted detailed crater size-frequency distribution (CSFD) measurements in the Chang’e-6 landing region, the southern mare of the Apollo basin. The southern mare is divided into western mare (W region) and eastern mare (E region), and then subdivided into five sub-units (W1, W2, W3, W4, W5) and three units (E1, E2, E3), respectively, according to the elevation, Ti and Fe abundances. Within the W2 and W5 region, more detailed sub-units were divided. The results show that the southern mare generally have two epochs, one of the Imbrian period and the other of the Eratothenian period. The basalt eruption lasted for ~1.7 Ga, from 3.28 Ga of the eastern mare to 1.54 Ga of the western mare. W region is younger than E region, while the three units of E region has an age of ~3.2 Ga. The ages of the western mare basalts range from 2.98 Ga to 1.54 Ga, lasting for 1.4 Ga. It’s worth noting that the age of the basalt at the Chang’e-6 sampling site is ~1.68 Ga, indicating the samples returned may include components with this very young age.

To understand dynamics in climate change, informing policy decisions and prompting timely action to mitigate its impact, this study provides a comprehensive analysis of the short-term trend of year-on-year CO2 emission changes across ten countries, considering a broad range of factors including socioeconomic, CO2-related industry, and education. This study uniquely goes beyond the common country-based analysis, offering a broader understanding of the interconnected impact of CO2 emissions across countries. Our preliminary regression analysis, using the ten most significant features, could only explain 66% of variations in the target. To capture emissions trend variation, we categorized countries by the change in CO2 emission volatility (high, moderate, low with upward or downward trends), assessed using standard deviation. We employed machine learning techniques, including feature importance analysis, Partial Dependence Plots (PDPs), sensitivity analysis, and Pearson and Canonical correlation analyses, to identify influential factors driving these short-term changes. The Decision Tree Classifier was the most accurate model, with an accuracy of 96%. It revealed population size, CO2 emissions from coal, the three-year average change in CO2 emissions, GDP, CO2 emissions from oil, education level (incomplete primary), and contribution to temperature rise as the most significant predictors, in order of importance. Furthermore, this study estimates the likelihood of a country transitioning to a higher emission category. Our findings provide valuable insights into the temporal dynamics of factors influencing CO2 emissions changes, contributing to global efforts to address climate change

In this paper, the concept of absolute airspace is further elaborated, and the time transform effect, the frequency transform relation of clock timing, and the principle of Doppler effect of special relativistic light are analyzed and demonstrated. Based on the concept of absolute airspace, a new and accurate Doppler effect relation of light (electromagnetic wave) is proposed. It is proved that there is a synchronous relationship between the time shift effect and the frequency change of the timing inside the clock. When the light (electromagnetic wave) source is in motion, the Doppler effect includes two physical mechanisms: the frequency change caused by time transformation effect and the frequency change caused by relative motion. When the light source is in motion, the Doppler effect of the light there are some differences in different directions due to the rotation of the earth. The relation of Doppler effect of special relativistic light is only a highly approximate relation, and its theoretical basis, special relativity, is flawed in principle.

The study of supermassive black holes has significantly advanced our understanding of galaxy structures, yet fundamental questions remain, particularly concerning the structure and dynamics of massive black holes. This article addresses the core structure of massive black holes, defined as those originating from supernova events. Integrating the concept of "Dachus density," a state of maximum matter density, I propose that the core of all massive black holes exists at this density. The research investigates the size of these cores and their event horizons, using Cygnus X-1 and Sagittarius A* as examples. Calculations reveal that the core size is exceedingly small compared to the overall black hole, with the core's volume being up to ~155 orders of magnitude smaller than the event horizon volume in the case of Sagittarius A*. The article briefly explores the implications of a rotating Dachus core on the black hole's structure, including the "mantle" region between the core and the event horizon. The discussion extends to absolute zero temperature, asserting that for a non-spinning, static Massive black hole, the temperature of its core reaches 0[K] as in this state, particles do not move in relation to each other and do not have any kinetic and in particular rotational Energy.

This study aims to apply a Recommendation System with Content Based Filtering method with Jaccard Similarity and Cosine Similarity algorithms on the E-Learning Platform. Recommendation systems deal with how to provide personalized recommendations to users efficiently. The Content Based Filtering method with Jaccard Similarity and Cosine Similarity algorithms can be used to calculate the similarity value between E-Courses on the E-Learning Platform. Implementation for Recommendation System using Google Colaboratory with Python programming language. In the application of the Recommendation System dataset, Coursera Free Dataset consists of 975 instances. The recommendation results use the Jaccard Similarity algorithm with an average similarity value of 0.3 while the value of Cosine Similarity with the average similarity value is 0.6 where the similarity value of Cosine Similarity is higher. Based on the results of the Mean Absolute Error in the low recommendation system, the average MAE value for all iterations of Jaccard Similarity algorithm is 0.013 and for the Cosine Similarity algorithm the average MAE value for all iterations is 0.014. This shows that the Recommendation System with Jaccard Similarity and Cosine Similarity algorithms can be used on the E-Learning Platform to provide efficiency solutions for personalized recommendations.

Diversified techniques have been applied in many research papers for the optimization of rehabilitation robotic movements in order to maintain smoothness and accuracy. Smooth and precise control is needed necessarily for upper limb rehabilitation robotic applications having five degree of freedom. The preferred parameters which are used for the controlling were validated by mathematical model and these tuning parameters were optimized. Designing optimization algorithms to control complex physical robots has been a challenging task. In this study, a number of optimization techniques will be analyzed to determine the optimal parameters of a PID controller with a dynamic model of the upper limb rehabilitation system. For determining optimal control parameters for PID, there exists a number of tuning methods such as Zeigler Nichols and fuzzy logic which are classical methods. Swarm intelligence-based optimization algorithms are inspired by the behaviors of living things in nature. Several researchers have reported the optimal design of PID controller parameters using optimization techniques. The proposed control technique has been implemented on a 5-DOF RAX hardware and before any clinical trials, six healthy subjects went for trials under strict protocol. It has been discovered that the proposed control technique rejects the external unwanted disturbances as well as keeps the system stable under extreme perturbed and harsh conditions. In this research paper mathematical models have been validated to determine the PID parameters for the optimization. The comparative study is carried out with four different cost functions since a well-designed objective function leads to better performance of the system and indicates control design expectations. These objective functions are an integral squared error (ISE) and integral absolute error (IAE). In this research work, the effects of different cost functions on optimization techniques for controller parameters were analyzed. The performance of the controller with different cost functions has examined for robustness analysis. The cost function of particle swarm optimization, Firefly, Ant Bee Colony and Ant Colony optimization were developed for the better optimization results.

In this study, we discuss the properties of absolute vacuum space and how these properties can play a vital role in creating a mechanism in which the very first particle gets created simultaneously everywhere and we find the limit in which when the absolute vacuum volume reaches will lead to the collapse that leads to the creation of the first particle. This discussion is made following to the elementary dimensions theory study that was peer-reviewed at the end of 2020, everything in the universe is made from four elementary dimensions, these dimensions are the three spatial dimensions (X, Y, and Z) and the Vacuum resistant as the factor of change among the four, time itself wasn’t considered as the fourth dimension, rather time corresponds to a factor of change, and during the research it was found out that the Vacuum resistant is the factor of change in the Absolute Vacuum space, where time is a hypothetical concept, that represents changes during certain events compared to a constant change rate event.Therefore, time does exist, but as a factor of change, and as the Vacuum resistant in the absolute vacuum space, Time= factor of change= Vacuum resistant. In the study, the internal and external vacuum resistant volume equivalent is found, External Vacuum resistant=3.2857602*10^15 *mass. This equation is used to identify the amount of Free external vacuum resistant created during nuclear fission and fusion: Initial mass of the excited nucleuses mass of the created new nucleuses+ 3.2857602*10^15 * the lost Mass. In elementary dimensions, the energy created during nuclear reactions is equivalent to the free External vacuum resistant created through nuclear reactions, and mass is equivalent to the internal Vacuum resistant.

A partial aperture onboard calibration method can solve the onboard calibration problems of some large aperture remote sensors, which is of great significance for the development trend of increasingly large apertures in optical remote sensors. In this paper, the solar diffuser reflectance degradation monitor (SDRDM) in the onboard calibration assembly (CA) of the FengYun-4 (FY-4) advanced geostationary radiance imager (AGRI) is used as the reference radiometer for measuring the partial aperture factor (PAF) for the AGRI onboard calibration. First, the linear response count variation relationship between the two is established under the same radiance source input. Then, according to the known bidirectional reflection distribution function (BRDF) of the solar diffuser (SD) in the CA, the relative reflectance ratio coefficient between the AGRI observation direction and the SDRDM observation direction is calculated. On this basis, the response count value of the AGRI and the SDRDM is used to realize the high-precision measurement of the PAF of the AGRI B1 ~ B3 bands by simulating the AGRI onboard calibration measurement under the illumination of a solar simulator in the laboratory. According to the determination process of the relevant parameters of the PAF, the measurement uncertainty of the PAF is analyzed; this uncertainty is better than 2.04% and provides an important reference for the evaluation of the onboard absolute radiometric calibration uncertainty after launch.

In proteomics, it is essential to quantify proteins in absolute terms if we wish compare results among studies and integrate high-throughput biological data into genome-scale metabolic models. While labeling target peptides with stable isotopes allows protein abundance to be accurately quantified, the utility of this technique is constrained by the low number of quantifiable proteins that it yields. Recently, label-free shotgun proteomics has become the “gold standard” for carrying out global assessments of biological samples containing thousands of proteins. However, this tool must be further improved if we wish to accurately quantify absolute levels of proteins. Here, we used different label-free quantification techniques to estimate absolute protein abundance in the model yeast Saccharomyces cerevisiae. More specifically, we evaluated the performance of seven different quantification methods, based either on spectral counting (SC) or extracted-ion chromatogram (XIC), which were applied to samples from five different proteome backgrounds. We also compared the accuracy and reproducibility of two strategies for transforming relative abundance into absolute abundance: a UPS2-based strategy and the total protein approach (TPA). This study mentions technical challenges related to UPS2 use and proposes ways of addressing them, including utilizing a smaller, more highly optimized amount of UPS2. Overall, three SC-based methods (PAI, SAF, and NSAF) yielded the best results because they struck a good balance between experimental performance and protein quantification.

Recently, polyacetylene (PA) is receiving a renewed scientific attention because of its unique properties potentially useful also for non-electrical applications (e.g., hydrogen storage, drug delivery, adsorbent of organic compounds in aqueous systems, gas and liquid separation, oxygen absorbent in gas analysis, etc.). Poly(vinyl alcohol) (PVOH) is a very common type of polymer, widely exploited in different technological areas, and it can be used as a precursor for the PA synthesis. Here, a new scheme for a large-scale chemical synthesis of PA, based on a simple and low-cost PVOH dehydration reaction by absolute sulfuric acid, has been developed. In this process, PVOH, shaped in form of film, is dipped in absolute sulfuric acid (i.e., H₂SO₄ at 95-97%) and, after complete chemical-dehydration at room temperature, it is mechanically removed from the liquid phase by using a plastic sieve. This reaction leads to a complete PVOH film conversion to PA as it has been proved by infrared spectroscopy (ATR-mode). Indeed, the ATR spectrum of the reaction product included all characteristic absorption bands of PA. To the best of our knowledge, this very easy and effective PA synthesis method based on the PVOH chemical-dehydration reaction by absolute sulfuric acid has never been described in the literature.

Two algorithms of data processing are proposed to shorten the unmeasurable dead-zone close to the zero-position of measurement, i.e., the minimum working distance of a dispersive interferometer using optical frequency comb, which is a critical issue in millimeter-order short-range absolute distance measurement. After demonstrating the limitation of the conventional data processing algorithm, the principles of the proposed algorithms, namely the spectral fringe algorithm, and the combined algorithm that combines the spectral fringe algorithm with the excess fraction method, are presented, together with simulation results for demonstrating the possibility of the proposed algorithms for shortening the dead-zone with a high accuracy. An experimental setup of dispersive interferometer is also constructed for implementing the proposed data processing algorithms over spectral interference signals. Experimental results demonstrate that the dead-zone by the proposed algorithms can be as small as half of that by the conventional algorithm while the measurement accuracy can be further improved with the combined algorithm.

Information overload is the biggest challenges nowadays for any website, especially the e-commerce website. However, this challenge arises for the fast growth of information on the web (WWW) with easy access to the internet. Collaborative filtering based recommender system is the most useful application to solve the information overload problem by filtering relevant information for the users according to their interests. But, the existing system faces some significant limitations like as data sparsity, low accuracy, cold-start and malicious attacks. To alleviate the mentioned issues, the relationship of trust incorporates in the system where it can be between the users or items, and such system is known as the trust-based recommender system (TBRS). From the user perspective, the motive of the TBRS is to utilize the reliability between the users to generate more accurate and trusted recommendations. However, the aim of the paper is to present a comparative analysis of different trust metrics in the context of the type of trust definition of TBRS. Also, the study accomplishes on twenty-four trust metrics in terms of the methodology, trust properties &amp; measurement, validation approaches, and the experimented dataset.

Background: Absolute uterine factor infertility (AUFI) is a kind of infertility that is completely attributable to uterine absence (surgical or congenital for women with Mayer-Rokitansky-Küster-Hauser syndrome: MRKH) or anatomic or functional abnormality that prevents embryo implantation or completion of pregnancy to term. Until recently, the only viable option to parenthood for couples with AUFI were adoption or surrogacy. Since a first attempt of uterus transplant (UTx) in 2000, nine babies were born from women with a transplanted uterus from 2014, eight of which in Sweden, and one in the United States. These promising results are raising immense hopes for the women with AUFI and there is optimism about the possibility for UTx to become part of clinical care even though, besides encouraging results, the procedure has also resulted in increased risks and harms for both the donors and recipients and increased risks of premature birth for the fetus. At present UTx is still considered as experimental and requiring more research and safety assessment before becoming a therapeutic option for AUFI. The transition from experimental procedure to therapeutic care would result in less strict ethical scrutiny for UTx and in the possibility for patients to get reimbursement for the procedure by the relevant healthcare insurance or public healthcare providers. In turn, an increase in the number of UTx performed yearly by specialized surgical teams would result in a general improvement of the “field strength”. However, at present it is difficult to establish the amount of evidence that we need in order to consider UTx as no longer experimental but routine clinical practice. The literature on UTx provides recommendations on the different outcomes that should be monitored in this experimental phase but no study is anticipating the number of subjects that should be followed and for how long. Conclusion: As for other transplants that have become routine practice, like renal transplant and heart transplant, it is likely that the decision on “routine practice readiness” will result from available cumulated evidences, from expert capacity to find a consensus on best practices and on political considerations as well, including pressures form patients and patient groups.

Permeability is an important transport property of porous materials, and its accurate evaluation is relevant in studying applied tasks such as CO2 injection into reservoirs and investigating groundwater quality issues. This study examines the dependence of permeability on total and connected porosity, hydraulic tortuosity, specific surface area, and mean pore radius based on the data of 408 cubic sub-volumes extracted from heterogeneous and naturally fractured cylindrical carbonate samples before and after injection of HCl solutions into them. These parameters were computed using pore-scale modeling of fluid flow. It has been shown that permeability correlates well with porosity and mean pore radius with correlation coefficients of R2≈0.65-0.79 for heterogeneous samples. It was found that the presence of natural fractures significantly influenced the relationship between permeability and other parameters. The relationship between permeability k, tortuosity τ, and specific surface area S is described by power laws k~τ-α and k~S-β, with coefficients α and β substantially exceeding those in the Kozeny-Carman equation. It was also found that there is a parabolic relationship between connected and total porosities both before and after rock dissolution with R2≈0.96-0.99. This allowed for estimation of percolation threshold porosity that are in good agreement with the literature data.

Bloodstream infection is a major health problem worldwide, with extremely high mortality. Detecting infection in the early stage is challenging due to the extremely low concentration of bacteria in the blood. Digital PCR provides unparalleled sensitivity and can achieve absolute quantification, but it is time-consuming. Moreover, the presence of unavoidable background signals in negative controls poses a significant challenge for single-molecule detection. Here, we propose a novel strategy called “Ultrafast flexible thin tube-based droplet digital PCR (utPCR)” that can shorten the digital PCR process from 2 hours to only 5 minutes, with primer annealing/extension time reduced from minutes to only 5 seconds. Importantly, the ultrafast PCR eliminates the nonspecific amplification and thus enables single-molecular detection. The utPCR enabled sensitive detection and digital quantification of E. coli O157 in the high background of 106-fold excess of E. coli K12 cells. Moreover, this method also displayed the potential to detect rare pathogens in blood samples, and the limit of detection (LOD) could be as low as 10 CFU per mL of blood without false positive results. Considering ultrafast (<5 min) and highly sensitive (single-molecule detection), the utPCR holds excellent prospects in the next generation of molecular diagnosis.

The variable-length arbitrary Lagrange-Euler (ALE)-ANCF finite element, which employ nonrational interpolating polynomials, cannot exactly describe the rational cubic Bezier curves such as conic and circular curves. The rational absolute nodal coordinate formulation (RANCF) finite element, whose reference length (undeformed length) is constant, can exactly represent the rational cubic Bezier curves. A new variable-length finite element called the ALE-RANCF finite element, which is capable of accurately describe the rational cubic Bezier curves, is proposed by combining the desirable features of the ALE-ANCF and RANCF finite element. In order to control the reference length of ALE-RANCF element within a suitable range, element segmentation and merging schemes are proposed. It is demonstrated that exact geometry and mechanic is maintained after the ALE-RANCF element is divided into two shorter ones, and compared with the ALE-ANCF elements, there are smaller deviations and oscillations after two ALE-RANCF elements are merged into a longer one. Numerical examples are presented and the feasibility and advantages of the ALE-RANCF finite element are demonstrated.

With the continuous development of 3D city modeling, traditional close-range photogrammetry is limited by complex processing procedures and incomplete 3D depth information, making it unable to meet high-precision modeling requirements. In contrast, the integration of LiDAR and camera in mobile measurement systems provides a new and highly effective solution. The LiDAR can quickly and accurately acquire the 3D spatial coordinates of target objects, while optical imagery contains abundant color information. If the two can be integrated, they can play an important role in multiple fields such as streetscape modeling, archaeology and digital city, etc. Currently, integrated mobile measurement systems commonly require cameras, lasers, POS and IMU, thus the hardware cost is relatively expensive and the system integration is complex. Therefore, in this paper we propose a simple ground mobile measurement system composed of a LiDAR and a GoPro camera without a POS system, providing a more convenient and reliable way to automatically obtain 3D point cloud data with spectral information. The automatic point cloud coloring based on video images mainly includes four aspects: (1) Establishing models for radial distortion and tangential distortion to correct video images. (2) Establishing a registration method based on normalized Zernike moments to obtain the exterior orientation elements. Normalized Zernike moments are region-based shape descriptors that can reflect the features of images in multiple dimensions even for low-quality video images. The results show that registration based on normalized Zernike moments provides a good result, with an error accuracy of 0.5-1 pixel, which is far higher than registration based on a collinearity equation. (3) Establishing adjacent video image relative orientation based on essential matrix decomposition and nonlinear optimization. This involves uniformly using the SURF algorithm with distance restriction and RANSAC to select corresponding points, which can improve the reliability of the corresponding points. The results indicate that the accuracy of the relative orientation method is high. Moreover, this method can converge to good results for stereo image pairs with large rotation angles and displacement amounts. Therefore, relative orientation based on essential matrix decomposition and nonlinear optimization has good applicability. (4) The video imagery suffers from significant motion blur and boundary distortion. Therefore, a point cloud coloring method based on Gaussian distribution with central region restriction is adopted. Only pixels within the central region are considered valid for coloring. Then, the point cloud is colored based on the mean of the Gaussian distribution of the color set. Experimental results show that the coloring accuracy between the video imagery and point cloud data is high, meeting the accuracy requirements of applications such as tunnel detection, street-view modeling and 3D urban modeling.

In 2004, first absolute gravity (AG) measurements were performed on the mountain tops of Mt. Zugspitze (2 sites) and Mt. Wank (1 site), and at the Wank foot (1 site). Wank (summit height 1780 m) and Zugspitze (2960 m) are about 20 km apart from each other and belong geologically to different parts of the Northern Limestone Alps. Bridging a time span of 15 years, the deduced gravity variations for Zugspitze are in the order of 0.30 μm/s² with a standard uncertainty of 0.04 μm/s². The Wank stations (foot and top) show no significant gravity variation. The vertical stability of Wank summit is also confirmed by results of continuous GNSS recordings. Because an Alpine mountain uplift of 1 or 2 mm/yr cannot explain the obtained gravity decline at Zugspitze, the dominating geophysical contributions are assumed to be due to the diminishing glaciers in the vicinity. The modelled gravity trend caused by glacier retreat between epochs 1999 and 2018 amounts to -0.012 μm/s²/yr at both Zugspitze AG sites. This explains more than half of the observed gravity decrease. Long-term variations on inter-annual and climate-relevant decadal scale will be investigated in the future using as a supplement superconducting gravimetry (installed in 2019) and GNSS equipment (since 2018).

The classical propositional calculus (zero-order logic, classical propositional logic), is the most fundamental two-valued logical system. In this paper we present a proof of inconsistency of the classical propositional calculus. Then, we get right away the conclusion that the metatheory of the classical propositional calculus is inconsistent.

An advanced driver-assistance system (ADAS) is critical to driver-vehicle-interaction systems. Driving behaviour modelling and control significantly improves the global performance of ADAS. A haptic assistive system assists the driver by providing a specific torque on the steering wheel according to the driving-vehicle-road profile to improve the steering control. However, the main problem is designing a compensator dealing with the high-level uncertainties in different driving scenarios with haptic driver assistance, where different personalities and diverse perceptions of drivers are considered. If not properly accounted for, these differences can lead to poor driving performance. This paper focuses on designing a data-driven model-free compensator considering various driving behaviours with a haptic feedback system. A back propagation neural network (BPNN) models driving behaviour based on real driving data (speed, acceleration, vehicle orientation, and current steering angle). Then using the genetic algorithm (GA) and the integral time absolute error (ITEA) criterion to optimize multiple PID compensation parameters for various driving behaviour (such as speeding/braking, lane-keeping and turning), which are then be combined by the fuzzy logic to provide different driving commands. An experiment was conducted with 5 participants in a driving simulator. During the second experiment, seven participants drove in the simulator to evaluate the robustness of the proposed combined GA-PID offline and the Fuzzy-PID controller applied online. The experiment results evaluated the ITAE of lateral displacement and yaw angle, during various driving behaviour. The results validated the proposed method by significantly enhancing the driving performance.

In the face of the upcoming 30th anniversary of econophysics, we review our contributions and other related works on the modeling of the long–range memory phenomenon in physical, economic, and other social complex systems. Our group has shown that the long–range memory phenomenon can be reproduced using various Markov processes, such as point processes, stochastic differential equations and agent–based models. Reproduced well enough to match other statistical properties of the financial markets, such as return and trading activity distributions and first–passage time distributions. Research has lead us to question whether the observed long–range memory is a result of actual long–range memory process or just a consequence of non–linearity of Markov processes. As our most recent result we discuss the long–range memory of the order flow data in the financial markets and other social systems from the perspective of the fractional Lèvy stable motion. We test widely used long-range memory estimators on discrete fractional Lèvy stable motion represented by the ARFIMA sample series. Our newly obtained results seem indicate that new estimators of self–similarity and long–range memory for analyzing systems with non–Gaussian distributions have to be developed.

As renewable energy generation prediction system has been introduced into the energy trading market, making a model to accurately predict the quantity of solar photovoltaic (PV) energy generation has become a significant problem. Moreover, to encourage an accurate prediction of the quantity of energy generation, an incentive system has been implemented for those who predict the quantity of solar PV energy under the error rate of 8%. Therefore, it has become more important to investigate and analyze current prediction technology numerically and develop more advanced prediction system. In this study, we tried to develop a better model to improve the accuracy of solar PV energy generation quantity by comparing three models made with gradient boosting machine (GBM), Model 1, Model 2, Model 3 respectively. Model 1 was built with the whole training data set without any additional preprocessing. After conducting some additional preprocessing procedure to predict solar energy generation more accurately, we made Model 2 with the whole training data set and Model 3 with only upper 10% of energy generation capacity. To compare the accuracy of three models, normalized mean absolute error (nMAE) was used as an evaluation index. The nMAE of Model 1 was 9.64% while the Model 2 showed 8.41%. Also, Model 3, which was constructed with the training set of upper 10% energy generation capacity, outperformed with the nMAE of 8.08%. For further study, to check the effectiveness of models constructed with GBM, a time series model, autoregressive integrated moving average (ARIMA), was also built and the nMAE was compared.

In the paper, the authors present an explicit form for a family of inhomogeneous linear ordinary differential equations, find a more significant expression for all derivatives of a function related to the solution to the family of inhomogeneous linear ordinary differential equations in terms of the Lerch transcendent, establish an explicit formula for computing all derivatives of the solution to the family of inhomogeneous linear ordinary differential equations, acquire the absolute monotonicity, complete monotonicity, the Bernstein function property of several functions related to the solution to the family of inhomogeneous linear ordinary differential equations, discover a diagonal recurrence relation of the Stirling numbers of the first kind, and derive an inequality for bounding the logarithmic function.

Recent wastewater testing suggests the poliovirus is reemerging, raising questions about the efficacy of the current inactivated polio vaccine and mass vaccination to eradicate poliomyelitis. The present study reassessed reported outcomes from the placebo-control study of the 1954 Salk inactivated poliomyelitis vaccine field trial, which studied a population of 1,829,916 U.S. school children from the first three grades. The placebo-control study of the trial reported that the polio vaccine was 80% to 90% effective in reducing cases of laboratory confirmed paralytic poliomyelitis, 60% to 70% effective against type 1 of the virus, and greater than 90% effective against types 2 and 3 of the poliovirus. However, these outcomes are reported as relative risk reductions, and the absolute risk reductions of the 1954 polio vaccine field trial were never reported to the public. The present paper’s analysis reveals to the public for the first time that the inactivated poliomyelitis vaccine's absolute risk reduction of laboratory confirmed paralytic poliomyelitis in the placebo-control study is 0.01% to 0.02%, an extraordinarily low clinical effect that impugns the Salk polio vaccine’s reported effectiveness. Furthermore, absolute risk reductions for the three poliovirus types are 0.01%, 0.00%, and 0.01%, respectively. Outcome reporting bias in the 1954 inactivated poliomyelitis vaccine field trial casts doubt on eradication of the poliovirus through mass vaccination.

The aim of the studies was to test the hydraulic pressure losses along the length, local pressure losses, absolute and relative roughness values of the pipeline walls made of modern polymer material. The article presents the results of the experimental studies of hydraulic resistance of pipelines from modern polymer materials, the method of theoretical determination of resistance coefficients in the VALTEC ISO 21003 metal polymer pipeline, the classification and method of determining the values of local hydraulic resistance coefficients of T-Junctions are given, the dependence for determining the Darcy λ hydraulic friction coefficient associated with the value of the equivalent hydraulic roughness coefficient of the inner surface of pipes and the Reynolds number. The experimental data of the hydraulic coefficient of friction Darcy λ was compared with the known theoretical relationships of A.D. Altschul, Colbrooke for smooth pipes, Colbrooke and White, an alternative to the Colbrooke-White, Offengenden equation for low-shear pipes and pipes from polymer materials with Reynolds numbers Re>10^4. Dependence of hydraulic coefficient of friction on relative equivalent roughness of pipeline walls and Reynolds number, specific energy loss per one linear meter on total flow rate in system of hydraulically short pipeline is obtained. The empirical dependence of values of coefficients of local resistance ζ=f(Q2/Q3) from a ratio of the divided expenses of Q2/Q3 of the equal-pass T-Junction α=90 the pipeline to a branch up, on pass in the direct T-Junction and division of streams at various internal pipeline diameters of VALTEC.

In the paper, the author (1) presents an explicit formula and its inversion formula for higher order derivatives of generating functions of the Bell polynomials, with the help of the Faà di Bruno formula, properties of the Bell polynomials of the second kind, and the inversion theorem for the Stirling numbers of the first and second kinds; (2) recovers an explicit formula and its inversion formula for the Bell polynomials in terms of the Stirling numbers of the first and second kinds, with the aid of the above explicit formula and its inversion formula for higher order derivatives of generating functions of the Bell polynomials; (3) constructs some determinantal and product inequalities and deduces the logarithmic convexity of the Bell polynomials, with the assistance of the complete monotonicity of generating functions of the Bell polynomials. These inequalities are main results of the paper.