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A Novel Hybrid VANET Routing Protocol with Dynamic Power Management for Performance Enhancement
Burke Geceyatmaz
,Fatma Tansu Hocanın
Posted: 01 January 2026
Adapt-Plan: A Hybrid Control Architecture for PEI-Guided Reliable Adaptive Planning in Dynamic Agentic Environments
Abuelgasim Mohamed Ibrahim Adam
Posted: 01 January 2026
Digital Technologies in Cardiac Rehabilitation for High-Risk
Cardiovascular Patients: A Narrative Review of Mobile Health,
Virtual Reality, Exergaming and Virtual Education
Aleksandra Rechcińska
,Barbara Bralewska
,Marcin Mordaka
,Tomasz Rechciński
Posted: 01 January 2026
Assessment of Meet-URO and CANLPH Prognostic Models in Metastatic RCC: Insights From a Single-Institution Cohort Predominantly Treated With TKIs
Ömer Faruk Kuzu
,Nuri Karadurmuş
,Nebi Batuhan Kanat
,Dilruba İlayda Özel Bozbağ
,Berkan Karadurmuş
,Esmanur Kaplan Tüzün
,Hüseyin Atacan
,Nurlan Mammadzada
,Emre Hafızoğlu
,Gizem Yıldırım
+3 authors
Background: Accurate prognostic assessment remains crucial in metastatic renal cell carcinoma (mRCC), especially as treatment options have expanded beyond vascular endothelial growth factor (VEGF)–targeted therapies to include immune checkpoint inhibitors (ICIs) and ICI–TKI combinations. The widely used IMDC classification shows important limitations in the modern therapeutic era, highlighting the need for complementary prognostic tools. In this context, the Meet-URO and CANLPH scores—incorporating clinical, inflammatory, and nutritional markers have emerged as promising alternatives. Objective: To evaluate and compare the prognostic performance of the Meet-URO and CANLPH scoring systems in a real-world mRCC cohort predominantly treated with first-line tyrosine kinase inhibitor (TKI) monotherapy due to limited access to ICI-based combinations. Methods: This retrospective single-center study included 112 patients with mRCC. The Meet-URO score was calculated for all patients, while the CANLPH score was assessed in 56 patients with complete laboratory data. CAR, NLR, and PHR were computed using baseline pre-treatment measurements. Overall survival (OS) and progression-free survival (PFS) the latter defined exclusively for first-line therapy—were estimated using the Kaplan–Meier method. Correlations between inflammatory markers and survival outcomes were analyzed using Spearman’s rho. Results: Meet-URO demonstrated clear prognostic stratification across all five categories, with the most favorable outcomes in score group 2 and progressively poorer OS and PFS in higher-risk groups. CANLPH also showed meaningful survival discrimination, with the highest inflammatory group (score 3) exhibiting markedly reduced OS and PFS. CAR was the strongest individual predictor of survival, while NLR and PHR showed weaker associations. Conclusion: Both Meet-URO and CANLPH provide strong, complementary prognostic information in mRCC, even in a cohort largely treated with TKI monotherapy. Their integration into routine risk assessment may enhance clinical decision-making, particularly in resource-limited settings.
Background: Accurate prognostic assessment remains crucial in metastatic renal cell carcinoma (mRCC), especially as treatment options have expanded beyond vascular endothelial growth factor (VEGF)–targeted therapies to include immune checkpoint inhibitors (ICIs) and ICI–TKI combinations. The widely used IMDC classification shows important limitations in the modern therapeutic era, highlighting the need for complementary prognostic tools. In this context, the Meet-URO and CANLPH scores—incorporating clinical, inflammatory, and nutritional markers have emerged as promising alternatives. Objective: To evaluate and compare the prognostic performance of the Meet-URO and CANLPH scoring systems in a real-world mRCC cohort predominantly treated with first-line tyrosine kinase inhibitor (TKI) monotherapy due to limited access to ICI-based combinations. Methods: This retrospective single-center study included 112 patients with mRCC. The Meet-URO score was calculated for all patients, while the CANLPH score was assessed in 56 patients with complete laboratory data. CAR, NLR, and PHR were computed using baseline pre-treatment measurements. Overall survival (OS) and progression-free survival (PFS) the latter defined exclusively for first-line therapy—were estimated using the Kaplan–Meier method. Correlations between inflammatory markers and survival outcomes were analyzed using Spearman’s rho. Results: Meet-URO demonstrated clear prognostic stratification across all five categories, with the most favorable outcomes in score group 2 and progressively poorer OS and PFS in higher-risk groups. CANLPH also showed meaningful survival discrimination, with the highest inflammatory group (score 3) exhibiting markedly reduced OS and PFS. CAR was the strongest individual predictor of survival, while NLR and PHR showed weaker associations. Conclusion: Both Meet-URO and CANLPH provide strong, complementary prognostic information in mRCC, even in a cohort largely treated with TKI monotherapy. Their integration into routine risk assessment may enhance clinical decision-making, particularly in resource-limited settings.
Posted: 01 January 2026
Single-Molecule Study of L-Asparaginase Thermal Denaturation
Еkaterina E. Vazhenkova
,Ivan D. Shumov
,Dmitry D. Zhdanov
,Victoria V. Shumyantseva
,Vadim S. Ziborov
,Alexander N. Ableev
,Andrey F. Kozlov
,Oleg N. Afonin
,Nikita V. Vaulin
,Denis V. Lebedev
+7 authors
Posted: 01 January 2026
Nutritional Risk Screening in Gynaecologic Oncology Surgery: Importance, Scoring Systems, Recommendations and Practical Applications
Laura Rachel Caley
,Iman Mustafa
,Oliver Jagus
,Helen Hutchinson
,Amudha Thangavelu
,Timothy Broadhead
,David Nugent
,Alexandros Laios
Posted: 01 January 2026
JAK3 Staining and CD68+ Macrophage Counts are Increased in Patients with IgA Nephropathy
Mateus Justi Luvizotto
,Precil Diego Miranda de Menezes Neves
,Cristiane Bitencourt Dias
,Lecticia Barbosa Jorge
,Luis Yu
,Luísa Menezes-Silva
,Magaiver Andrade-Silva
,Renato C. Monteiro
,Niels Olsen Saraiva Câmara
,Viktoria Woronik
Background/Objectives: IgA nephropathy (IgAN) is the most common primary glomerulopathy worldwide; it is characterized by a complex pathophysiology involving several inflammatory pathways. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway may be critical in this process. This study aimed to investigate the role of this pathway in IgAN and examine related tissue inflammatory markers. Methods: We analyzed 63 biopsy-confirmed patients with IgAN and performed immunohistochemical analysis on renal samples. A panel of antibodies targeting the JAK/STAT pathway, including JAK2, JAK3, p-STAT, STAT3, and MAPK/ERK, was used for this analysis. Six kidney tumor border samples were used as controls. Additionally, CD68 staining was used to evaluate tissue inflammation in the kidney biopsies. Results: Patients with IgAN showed a significantly higher cellular density of JAK3 staining at the glomerular level compared to controls, indicating JAK3 activation (p < 0.0002). Nevertheless, the correlation between JAK3 positivity in glomeruli and clinical parameters such as the initial and final estimated glomerular filtration rate (eGFR) and proteinuria was not statistically significant. Identical results were obtained with CD68+ macrophage counts in the glomerular compartment, which did not show any correlation with clinical parameters, while CD68+ tubulointerstitial staining demonstrated a significant correlation with both initial (p = 0.002) and final eGFRs (p = 0.0014), proteinuria (p = 0.010), and interstitial fibrosis (p < 0.001), as well as with renal disease progression (p = 0.005). Conclusions: Patients with IgAN exhibited activation of the JAK/STAT pathway, in contrast to controls. Macrophage CD68 staining in the tubulointerstitial area increased and was associated with clinical and laboratory parameters such as eGFR and proteinuria. Additionally, MEST-C histological parameters, such as segmental glomerulosclerosis (S0/S1), tubular atrophy/interstitial fibrosis (T0/T1/T2), and crescents (C0/C1/C2), were associated with a higher number of CD68+ cells.
Background/Objectives: IgA nephropathy (IgAN) is the most common primary glomerulopathy worldwide; it is characterized by a complex pathophysiology involving several inflammatory pathways. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway may be critical in this process. This study aimed to investigate the role of this pathway in IgAN and examine related tissue inflammatory markers. Methods: We analyzed 63 biopsy-confirmed patients with IgAN and performed immunohistochemical analysis on renal samples. A panel of antibodies targeting the JAK/STAT pathway, including JAK2, JAK3, p-STAT, STAT3, and MAPK/ERK, was used for this analysis. Six kidney tumor border samples were used as controls. Additionally, CD68 staining was used to evaluate tissue inflammation in the kidney biopsies. Results: Patients with IgAN showed a significantly higher cellular density of JAK3 staining at the glomerular level compared to controls, indicating JAK3 activation (p < 0.0002). Nevertheless, the correlation between JAK3 positivity in glomeruli and clinical parameters such as the initial and final estimated glomerular filtration rate (eGFR) and proteinuria was not statistically significant. Identical results were obtained with CD68+ macrophage counts in the glomerular compartment, which did not show any correlation with clinical parameters, while CD68+ tubulointerstitial staining demonstrated a significant correlation with both initial (p = 0.002) and final eGFRs (p = 0.0014), proteinuria (p = 0.010), and interstitial fibrosis (p < 0.001), as well as with renal disease progression (p = 0.005). Conclusions: Patients with IgAN exhibited activation of the JAK/STAT pathway, in contrast to controls. Macrophage CD68 staining in the tubulointerstitial area increased and was associated with clinical and laboratory parameters such as eGFR and proteinuria. Additionally, MEST-C histological parameters, such as segmental glomerulosclerosis (S0/S1), tubular atrophy/interstitial fibrosis (T0/T1/T2), and crescents (C0/C1/C2), were associated with a higher number of CD68+ cells.
Posted: 01 January 2026
A Novel One-Step Remote Sensing Methodology for Actual Evapotranspiration Estimation
Halil Karahan
Accurately estimating actual evapotranspiration (ETa) is essential for sustainable water management, particularly in semi-arid regions. Although the SAFER algorithm provides a practical remote sensing-based approach, its sensitivity to parameter settings and reduced performance during dry periods limit its reliability. This study develops four parametric ETa models—two linear (LM-I, LM-II) and two nonlinear (NLM-I, NLM-II)—and recalibrates SAFER coefficients via a simulation/optimization (S/O) approach. Models were evaluated using Landsat-8 data (LST, NDVI, αₛ) and reference evapotranspiration (ETo), and compared with machine learning methods: Random Forest (RF), Bagged Trees (BT), Support Vector Machines (SVM), and Generalized Additive Models (GAM). Results indicate that nonlinear models better capture the physical behavior of ET processes and outperform linear models across key metrics. In particular, the NLM-II model achieved R² = 0.8295 and RMSE = 0.4913 on the test set, surpassing SAFER (R² = 0.8195, RMSE ≈ 0.5713), LM-II, and the best soft computing model, BT (R² = 0.8137, RMSE = 0.5084). Its physically grounded structure ensures stable, interpretable predictions that accurately reflect water–energy interactions and seasonal dynamics. These findings demonstrate that compact, physically based nonlinear parametric models provide a robust, operationally practical solution for ETa estimation under sparse Landsat-based datasets, outperforming both linear and black-box machine learning approaches.
Accurately estimating actual evapotranspiration (ETa) is essential for sustainable water management, particularly in semi-arid regions. Although the SAFER algorithm provides a practical remote sensing-based approach, its sensitivity to parameter settings and reduced performance during dry periods limit its reliability. This study develops four parametric ETa models—two linear (LM-I, LM-II) and two nonlinear (NLM-I, NLM-II)—and recalibrates SAFER coefficients via a simulation/optimization (S/O) approach. Models were evaluated using Landsat-8 data (LST, NDVI, αₛ) and reference evapotranspiration (ETo), and compared with machine learning methods: Random Forest (RF), Bagged Trees (BT), Support Vector Machines (SVM), and Generalized Additive Models (GAM). Results indicate that nonlinear models better capture the physical behavior of ET processes and outperform linear models across key metrics. In particular, the NLM-II model achieved R² = 0.8295 and RMSE = 0.4913 on the test set, surpassing SAFER (R² = 0.8195, RMSE ≈ 0.5713), LM-II, and the best soft computing model, BT (R² = 0.8137, RMSE = 0.5084). Its physically grounded structure ensures stable, interpretable predictions that accurately reflect water–energy interactions and seasonal dynamics. These findings demonstrate that compact, physically based nonlinear parametric models provide a robust, operationally practical solution for ETa estimation under sparse Landsat-based datasets, outperforming both linear and black-box machine learning approaches.
Posted: 01 January 2026
Combination of Physical and Geostatistical Models for Assessing Surface Moisture in Semiarid Agricultural Soils with Sentinel-1 Through Remote Sensing
Álvaro Arroyo Segovia
,Adrian Fernández-Sánchez
Posted: 01 January 2026
Adoption of Deep Learning Driven Precision Agriculture for Optimizing Crop Productivity and Soil Health via Predictive Analytics and Autonomous Sensing Mechanisms
Shuriya B.
The integration of artificial intelligence (AI) in precision agriculture marks a transformative step toward sustainable, efficient, and data-driven farming practices. By merging AI with predictive analytics and autonomous monitoring systems, agriculture is empowered to achieve higher crop yields and maintain robust soil health. AI-driven models process vast datasets from sensors, drones, and IoT devices to predict crop performance, recommend targeted interventions, and enable real-time monitoring of field conditions. This synergy not only allows for early detection of threats such as pests or nutrient deficiencies but also ensures optimized resource utilization, reducing environmental impact. The adoption of these intelligent systems paves the way for a resilient agricultural landscape that can adapt to the challenges posed by climate variability and the growing global food demand, ultimately fostering productivity and long-term ecological sustainability.
The integration of artificial intelligence (AI) in precision agriculture marks a transformative step toward sustainable, efficient, and data-driven farming practices. By merging AI with predictive analytics and autonomous monitoring systems, agriculture is empowered to achieve higher crop yields and maintain robust soil health. AI-driven models process vast datasets from sensors, drones, and IoT devices to predict crop performance, recommend targeted interventions, and enable real-time monitoring of field conditions. This synergy not only allows for early detection of threats such as pests or nutrient deficiencies but also ensures optimized resource utilization, reducing environmental impact. The adoption of these intelligent systems paves the way for a resilient agricultural landscape that can adapt to the challenges posed by climate variability and the growing global food demand, ultimately fostering productivity and long-term ecological sustainability.
Posted: 01 January 2026
The Future of Bioarchaeological Data: Why FAIR, CARE, and Machine Learning Are Essential for Sustainable Research
Alphaeus Lien-Talks
Posted: 01 January 2026
Whole-Genome Sequencing of Staphylococcus cohnii Isolated from Healthy Human Skin: Insights into Genomic Features and Antibacterial Potential
Duc Huy Nguyen
,Thi Chau Anh Nguyen
,Thi Minh Nga Nguyen
,Ha Minh Nhat Truong
,Thi Khanh Linh Nguyen
,Thi Tuyen Nguyen
,Thi Ngoc Mai Duong
,Thi Hai Dinh
,Van An Le
,Dinh Binh Tran
Posted: 01 January 2026
Conformally Compactified Minkowski Space: A Re-Examination with Emphasis on the Double Cover and Conformal Infinity
Arkadiusz Jadczyk
This paper presents a detailed re-examination of the conformal compactification of Minkowski space, \( \overline{M} \), constructed as the projective null cone of the six-dimensional space \( \mathbb{R}^{4,2} \). We provide an explicit and basis-independent formulation, emphasizing geometric clarity. A central result is the explicit identification of \( \overline{M} \) with the unitary group U(2) via a diffeomorphism, offering a clear matrix representation for points in the compactified space. We then systematically construct and analyze the action of the full conformal group \( \mathrm{O}(4,2) \) and its connected component \( \mathrm{SO}_0(4,2) \) on this manifold. A key contribution is the detailed study of the double cover, \( \overline{\overline{M}} \), which is shown to be diffeomorphic to \( S^3 \times S^1 \). This construction resolves the non-effectiveness of the \( \mathrm{SO}(4,2) \) action on \( \overline{M} \), yielding an effective group action on the covering space. A significant portion of our analysis is devoted to a precise and novel geometric characterization of the conformal infinity. Moving beyond the often-misrepresented ``double cone'' description, we demonstrate that the infinity of the double cover, \( \overline{\overline{M}}_\infty \), is a squeezed torus (specifically, a horn cyclide), while the simple infinity, \( \overline{M}_\infty \), is a needle cyclide. We provide explicit parametrizations and graphical representations of these structures. Finally, we explore the embedding of five-dimensional constant-curvature spaces, whose boundary is the compactified Minkowski space, and discuss the interpretation of geodesics within these domains. The paper aims to clarify long-standing misconceptions in the literature and provides a robust, coordinate-free geometric foundation for conformal compactification, with potential implications for cosmology and conformal field theory.
This paper presents a detailed re-examination of the conformal compactification of Minkowski space, \( \overline{M} \), constructed as the projective null cone of the six-dimensional space \( \mathbb{R}^{4,2} \). We provide an explicit and basis-independent formulation, emphasizing geometric clarity. A central result is the explicit identification of \( \overline{M} \) with the unitary group U(2) via a diffeomorphism, offering a clear matrix representation for points in the compactified space. We then systematically construct and analyze the action of the full conformal group \( \mathrm{O}(4,2) \) and its connected component \( \mathrm{SO}_0(4,2) \) on this manifold. A key contribution is the detailed study of the double cover, \( \overline{\overline{M}} \), which is shown to be diffeomorphic to \( S^3 \times S^1 \). This construction resolves the non-effectiveness of the \( \mathrm{SO}(4,2) \) action on \( \overline{M} \), yielding an effective group action on the covering space. A significant portion of our analysis is devoted to a precise and novel geometric characterization of the conformal infinity. Moving beyond the often-misrepresented ``double cone'' description, we demonstrate that the infinity of the double cover, \( \overline{\overline{M}}_\infty \), is a squeezed torus (specifically, a horn cyclide), while the simple infinity, \( \overline{M}_\infty \), is a needle cyclide. We provide explicit parametrizations and graphical representations of these structures. Finally, we explore the embedding of five-dimensional constant-curvature spaces, whose boundary is the compactified Minkowski space, and discuss the interpretation of geodesics within these domains. The paper aims to clarify long-standing misconceptions in the literature and provides a robust, coordinate-free geometric foundation for conformal compactification, with potential implications for cosmology and conformal field theory.
Posted: 01 January 2026
A Deep Learning–Driven Method for Bowl Tableware Reconstruction and the Prediction of Liquid Volume and Food Nutrient Content
Xu Ji
,Kai Song
,Lianzheng Sun
,Haolin Lu
,Hengyuan Zhang
,Yiran Feng
Posted: 01 January 2026
India’s Macroeconomic Variables Response to Global Scenario's—Evidence from Oil Price Shocks, Global Financial Crisis and COVID-19
Nikhil Bhardwaj
,Ivana Miklošević
,Nalinee Chauhan
Posted: 01 January 2026
Improved Quality of Life in Children and Families following Enrollment in a Pediatric Palliative Care Program: A Prospective Cohort Study
Jéssica H. Guadarrama-Orozco
,María G. Mendoza-Martínez
,Sergio E. Bautista-Téllez
,Paola Yañez-Maldonado
,Karina Mendoza-de la Mendoza-de-la-Vega
,María F. Castilla-Peon
Posted: 01 January 2026
Early Empathic Responses and Prosociality in a Simulated Distress Context: Evidence from Colombian Children
Mayilin Moreno-Torres
,Paola Molina
Background/Objectives: Prosocial behaviors such as helping, sharing, and comforting constitute a core aspect of human sociality and emerge early in development. Understanding how early empathic responses are organized is central to current debates on the developmental foundations of prosociality, particularly beyond Western, educated, industrialized, rich, and democratic (WEIRD) populations. This study examined the developmental organization of early empathic responses and the contributions of age, sex, and socioeconomic context to variability in early prosocial behavior. Methods: Thirty-six Colombian children aged 14 to 30 months from three socioeconomic contexts (very low, low, and middle–high), including children from indigenous Wayuu communities, were observed during a simulated distress situation derived from the Échelle de Communication Sociale Précoce (ECSP). Empathic responses were coded using the expanded hierarchical classification proposed by Molina and Bulgarelli and summarized through an ordinal empathy score reflecting the highest level of empathic organization observed. Quantitative analyses were complemented by qualitative observations of interactional behavior. Results: Empathic response organization increased with age and was positively associated with overall socio-communicative development. No significant differences were observed according to sex or socioeconomic context. Qualitative analyses revealed a progressive organization of empathic responses, ranging from attention and discomfort to coordinated gestural and symbolic prosocial behaviors, consistent across sociocultural settings. Conclusions: Early empathy appears as an interactionally organized and developmentally robust foundation of prosocial behavior during the first three years of life. These findings contribute to ongoing discussions on the early bases of human prosociality and its expression across diverse sociocultural contexts.
Background/Objectives: Prosocial behaviors such as helping, sharing, and comforting constitute a core aspect of human sociality and emerge early in development. Understanding how early empathic responses are organized is central to current debates on the developmental foundations of prosociality, particularly beyond Western, educated, industrialized, rich, and democratic (WEIRD) populations. This study examined the developmental organization of early empathic responses and the contributions of age, sex, and socioeconomic context to variability in early prosocial behavior. Methods: Thirty-six Colombian children aged 14 to 30 months from three socioeconomic contexts (very low, low, and middle–high), including children from indigenous Wayuu communities, were observed during a simulated distress situation derived from the Échelle de Communication Sociale Précoce (ECSP). Empathic responses were coded using the expanded hierarchical classification proposed by Molina and Bulgarelli and summarized through an ordinal empathy score reflecting the highest level of empathic organization observed. Quantitative analyses were complemented by qualitative observations of interactional behavior. Results: Empathic response organization increased with age and was positively associated with overall socio-communicative development. No significant differences were observed according to sex or socioeconomic context. Qualitative analyses revealed a progressive organization of empathic responses, ranging from attention and discomfort to coordinated gestural and symbolic prosocial behaviors, consistent across sociocultural settings. Conclusions: Early empathy appears as an interactionally organized and developmentally robust foundation of prosocial behavior during the first three years of life. These findings contribute to ongoing discussions on the early bases of human prosociality and its expression across diverse sociocultural contexts.
Posted: 01 January 2026
Short-Run Monetary Policy Transmission, Credit Risk, and Bank Portfolio Adjustments: Evidence from the Non-Financial Corporate Sector in an Emerging Economy
Adil Boutfssi
,Tarik Quamar
Posted: 01 January 2026
Fluency and Connectedness: Building the Foundation for Language Development in Deaf and Hard-of-Hearing Children
Carrie Davenport
,Katharine Suma
,Elaine Smolen
,Precious-Janae Romain
,Robert Bourque
,Roberta Michnick Golinkoff
,Derek Houston
Posted: 01 January 2026
Local Recovery of Magnetic Invariants from Local Length Measurements in Non-Reversible Randers Metrics
Aymane Touat
We study a purely local inverse problem for non-reversible Randers metrics \( F = \|\cdot\|_g + \beta \) defined on smooth oriented surfaces. Using only the lengths of sufficiently small closed curves around a point \( p \), we prove that the exterior derivative \( d\beta(p) \) can be uniquely and stably recovered. Moreover, we establish that \( d\beta(p) \) is the only second-order local invariant retrievable from such local length measurements. Our approach is entirely metric-based, independent of geodesic flows or boundary data, and naturally extends to general curved surfaces.
We study a purely local inverse problem for non-reversible Randers metrics \( F = \|\cdot\|_g + \beta \) defined on smooth oriented surfaces. Using only the lengths of sufficiently small closed curves around a point \( p \), we prove that the exterior derivative \( d\beta(p) \) can be uniquely and stably recovered. Moreover, we establish that \( d\beta(p) \) is the only second-order local invariant retrievable from such local length measurements. Our approach is entirely metric-based, independent of geodesic flows or boundary data, and naturally extends to general curved surfaces.
Posted: 01 January 2026
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