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The Characteristics of Patients that Develop Severe Leptospirosis: A Scoping Review
Patrick Rosengren,
Liam Johnston,
Ibrahim Ismail,
Simon Smith,
Josh Hanson
Posted: 12 November 2025
Factors Predicting the Rate of Decline of FEV1 Values in Patients with Chronic Obstructive Pulmonary Disease
Jovana Maskovic Pekmezovic,
Jelena Cvejic,
Ivana Sekulovic Radovanovic,
Ivana Buha,
Dragana Maric
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive condition and a leading cause of morbidity and mortality worldwide. The rate of forced expiratory volume in one second (FEV1) decline is a key prognostic marker. This study aimed to evaluate the impact of demographic, clinical, and therapeutic factors, including respiratory muscle strength and inhaled corticosteroid (ICS) use, on FEV1 decline.Methods: A prospective study was conducted in 2019 at the Clinic for Pulmonology, Clinical Center of Serbia. Fifty patients with stable COPD underwent spirometry, body plethysmography, respiratory muscle strength testing, and laboratory analyses. Demo-graphic and clinical data were collected via questionnaire. All assessments were repeated after six months of regular inhalation therapy.Results: Significant reductions were observed in FEV1, FVC, TLC, PImax, and PEmax. Lower baseline respiratory muscle strength predicted a faster FEV1 decline. Patients in GOLD stage 2 and those with greater hyperinflation exhibited accelerated functional deterioration. Therapy type affected selected parameters: LABA/ICS and LAMA/LABA/ICS regimens significantly reduced residual volume, but not the rate of FEV1 decline. Higher eosinophil counts were associated with a slower reduction in FEV1, suggesting a potential protective effect of ICS.Conclusion: Respiratory muscle strength, hyperinflation, and eosinophil count represent important predictors of COPD progression. Incorporating these parameters into diagnostic and therapeutic algorithms may improve early risk stratification and support indi-vidualized treatment strategies.
Introduction: Chronic obstructive pulmonary disease (COPD) is a progressive condition and a leading cause of morbidity and mortality worldwide. The rate of forced expiratory volume in one second (FEV1) decline is a key prognostic marker. This study aimed to evaluate the impact of demographic, clinical, and therapeutic factors, including respiratory muscle strength and inhaled corticosteroid (ICS) use, on FEV1 decline.Methods: A prospective study was conducted in 2019 at the Clinic for Pulmonology, Clinical Center of Serbia. Fifty patients with stable COPD underwent spirometry, body plethysmography, respiratory muscle strength testing, and laboratory analyses. Demo-graphic and clinical data were collected via questionnaire. All assessments were repeated after six months of regular inhalation therapy.Results: Significant reductions were observed in FEV1, FVC, TLC, PImax, and PEmax. Lower baseline respiratory muscle strength predicted a faster FEV1 decline. Patients in GOLD stage 2 and those with greater hyperinflation exhibited accelerated functional deterioration. Therapy type affected selected parameters: LABA/ICS and LAMA/LABA/ICS regimens significantly reduced residual volume, but not the rate of FEV1 decline. Higher eosinophil counts were associated with a slower reduction in FEV1, suggesting a potential protective effect of ICS.Conclusion: Respiratory muscle strength, hyperinflation, and eosinophil count represent important predictors of COPD progression. Incorporating these parameters into diagnostic and therapeutic algorithms may improve early risk stratification and support indi-vidualized treatment strategies.
Posted: 12 November 2025
The Role of microRNAs as Potential Biomarkers in Diffuse Large B-cell Lymphoma
Eirini Panteli,
Epameinondas Koumpis,
Vasileios Georgoulis,
Georgios Petros Barakos,
Evangelos Kolettas,
Panagiotis Kanavaros,
Alexandra Papoudou Bai,
Eleftheria Hatzimichael
Posted: 12 November 2025
Evaluation of Influenza A/B, SARS-CoV-2, and RSV Antigen Combo Rapid Test in Under Two Hospitalized Children
Birhan Mulugeta,
Dessalegn Fentahun,
Dawit Hialu,
Asmare Moges,
Abiy Ayele Angelo,
Getu Girmay,
Abaysew Ayele,
Tesfaye Gelanew
Posted: 12 November 2025
Exploring the Relationship Between Diet and Rheumatoid Arthritis – A Review of the Literature
Emil Parikh
Posted: 12 November 2025
Immunolocalization of p53 and p21 in Kidneys Exposed to T-2 Mycotoxin
Piret Hussar,
Katerina Blagoevska,
Monika Dovenska,
Lazo Pendovski,
Florina Popovska-Percinic
Posted: 12 November 2025
Proteomic Profiling of Fucoidan’s Cardioprotective Effects in a Pressure Overload Model
Wen-Rui Hao,
Fu-An Li,
Huan-Yuan Chen,
Tzu-Hurng Cheng,
Jin-Jer Chen
Posted: 12 November 2025
A Weakly Supervised Approach for HPV Status Prediction in Oropharyngeal Carcinoma from H&E-Stained Slides
Angela Crispino,
Silvia Varricchio,
Alessandra Marfella,
Dora Cerbone,
Daniela Russo,
Rosa Maria Di Crescenzo,
Stefania Staibano,
Francesco Merolla,
Gennaro Ilardi
Posted: 12 November 2025
DAXX and ATRX Expression in Canine Prostate and Bladder Cancer Identified by Digital Quantitative Immunohistochemistry
Annika Spitzer,
Heike Aupperle-Lellbach,
Martin Spitzer,
Silvia Weidle,
Leonore Aeschlimann,
Robert Klopfleisch,
Simone de Brot
Posted: 12 November 2025
Eastern European Fermented Foods: Nutritional Value, Functional Potential, and Cultural Heritage
Corina-Aurelia Zugravu,
Ciprian Constantin
Posted: 12 November 2025
Targeting Molecular Dysregulation in Inflammatory Bowel
Disease: A Cellular Perspective
Roxana Elena Mirică,
Andrei Coman,
Monica State,
Cristiana Popp
Posted: 12 November 2025
Quality of Bowel Preparation in the General Population
Melanija Ražov Radas,
Ivo Klarin,
Marija Ljubičić
Background and Objectives: With more than 1.9 million new cases and 0.9 million deaths in 2020, colorectal cancer (CRC) was the third most common cancer and the second most common cause of cancer mortality worldwide. The adenoma detection rate as a precursor to the formation of CRC is directly related to the degree of bowel preparation for colonoscopy.Materials and Methods: This is a retrospective single-center study on a total number of 4835 colonoscopies performed in a period of 34 months during the global COVID-19 pandemic.The main goal of the research was related to the emergence of differences in cleaning in relation to gender, age, days of preparation, the type of cleaning agent.Results: There is no signification difference between gender. Compared to younger respondents, older respondents had a lower likelihood of having adequate bowel preparation. Compared to PEG, other solutions had a lower probability of adequate bowel preparation.Conclusions: Better cooperation between patients and medical staff is needed, as well as public health campaigns that raise awareness of the importance of good preparation for colonoscopy.
Background and Objectives: With more than 1.9 million new cases and 0.9 million deaths in 2020, colorectal cancer (CRC) was the third most common cancer and the second most common cause of cancer mortality worldwide. The adenoma detection rate as a precursor to the formation of CRC is directly related to the degree of bowel preparation for colonoscopy.Materials and Methods: This is a retrospective single-center study on a total number of 4835 colonoscopies performed in a period of 34 months during the global COVID-19 pandemic.The main goal of the research was related to the emergence of differences in cleaning in relation to gender, age, days of preparation, the type of cleaning agent.Results: There is no signification difference between gender. Compared to younger respondents, older respondents had a lower likelihood of having adequate bowel preparation. Compared to PEG, other solutions had a lower probability of adequate bowel preparation.Conclusions: Better cooperation between patients and medical staff is needed, as well as public health campaigns that raise awareness of the importance of good preparation for colonoscopy.
Posted: 12 November 2025
Advances in Nonpharmacological Approaches, Such as Baroreceptor Stimulation, for the Treatment of Resistant Hypertension
Paramita Juardar
Posted: 12 November 2025
Dynamic Changes in Albumin and Systemic Immune-Inflammation Index as Prognostic Markers in Patients Treated with Cabozantinib After Immune Checkpoint Inhibitors for Metastatic Renal Cell Carcinoma
Rikushi Fujimura,
Hiroshi Yaegashi,
Ryunosuke Nakagawa,
Taiki Kamijima,
Hiroshi Kano,
Tomoyuki Makino,
Renato Naito,
Suguru Kadomoto,
Hiroaki Iwamoto,
Kazuyoshi Shigehara
+3 authors
Posted: 11 November 2025
Inborn Errors of Amino Acid Metabolism Revisited: Clinical Implications and Insights into Current Therapies
Abdul L. Shakerdi,
Darragh Nerney,
Eleanor J. Molloy,
Ina Knerr
Posted: 11 November 2025
Connecting the Airways: Current Trends in United Airway Diseases
Benedetta Bondi,
Martina Buscema,
Federico Di Marco,
Carlo Conti,
Andrea Caviglia,
Lorenzo Fucci,
Anna Maria Riccio,
Marcello Mincarini,
Martina Ottoni,
Fulvio Braido
+2 authors
Posted: 11 November 2025
Diabetic Foot—Scope of the Problem Worldwide: The Challenge of Data Management
Iztok Štotl
Posted: 11 November 2025
Long-Term Impact of Antimicrobial Stewardship Strategies on Antibiotic Prescribing and Gram-Negative Bacilli Susceptibility: A 17-Year Experience
Yvonne Peijun Zhou,
Shimin Jasmine Chung,
Winnie Hui Ling Lee,
Yi Bo Wang,
Shena Yun Chun Lim,
Yen Ee Tan,
Andrea Lay Hoon Kwa
Posted: 11 November 2025
Effective Adolescent Hand CRPS Type 1 Treatment Using Ketamine, Gabapentin, and Supraclavicular Nerve Block Catheter
Harshini Medikondu,
Alexander Davit,
Mihaela Visoiu
Posted: 11 November 2025
Pathogen-Specific Risk for Iterative Surgical Debridement in Orthopedic Infections: A Prospective Multicohort Analysis
Flamur Zendeli,
Anna Jedrusik,
Raymond O Schäfer,
David Albrecht,
Michael Betz,
Felix WA Waibel,
Tanja Gröber,
Nathalie Kuehne,
Sören Könneker,
İlker Uçkay
Posted: 11 November 2025
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