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Anticancer Structure-Activity Relationship in Well-Characterized Pt(IV) Compounds: Pt(CH3)2I2{6,6’-dimethyl-2,2’-bipyridine} Cytotoxicity Against Colon and Ovarian Carcinoma Cell Lines
Shadrach Stitz
,William A. Howard
,Kraig A. Wheeler
,Natarajab Ganesan
,David G. Churchill
Posted: 18 March 2026
Design and Experimental Evaluation of a Microstrip Antenna for DVB-T2 System with Comparative Radio and Quality Measurements
Design and Experimental Evaluation of a Microstrip Antenna for DVB-T2 System with Comparative Radio and Quality Measurements
Bogdan Uljasz
,Rafał Przesmycki
,Marek Bugaj
,Iwona Uljasz
,Kuba Bugaj
Posted: 18 March 2026
The Concept of Development of Insulin Resistance in Type 2 Diabetes Mellitus: A Systematic Review
The Concept of Development of Insulin Resistance in Type 2 Diabetes Mellitus: A Systematic Review
Kuat P. Oshakbayev
,Altay N. Nabiyev
,Aigul K. Durmanova
,Gani M. Kuttymuratov
,Timur S. Suleimenov
,Nurzhan A. Bikhanov
,Alisher S. Idrissov
,Guldana Zh. Bazheneyeva
,Kenzhekyz Manekenova
,Ainur A. Akilzhanova
+1 authors
Background: The impact of overweight and adipocyte size on the development of type 2 diabetes mellitus (T2DM) even remains unclear. Aim: To study: 1) the relationship between the state of adipocytes and/or overweight/obesity, the development of T2DM and its clinical and laboratory signs; 2) the effect of weight loss on glycemic level, hyperinsulinemia (HI), insulin resistance (IR), and T2DM status. Methods. Design: a systematic review. Settings: Web of Science, EBSCO, Scopus/ Science-Direct, Google Scholar, PubMed, Cochrane, и Wolter Kluwer were searched for articles published for 26 years (2000-2026). The study bases on a systematic review of 3853 articles published worldwide. Results. In total, 142 full-text articles were assessed for eligibility. With an increase in overweight, the size of adipose tissue increases, adipocytes increase, the cell radius increase. All it leads to an overload of intracellular transport and internal organs. Increase in cell size triggers intracellular mechanisms to limit further nutrient supply. When cell size increases excessively, conformational changes in cellular receptors are activated, resulting in the development of IR. The increase in cell size and the maximum accumulation of overweight, as parallel processes, lead to hyperglycemia and HI with gradual development of IR and T2DM. Any type of intentional weight loss leads to a decrease in IR, HI and the disappearance of T2DM. Targeted weight loss in patients with T2DM improves metabolic and cardiovascular health, reduces blood pressure and blood sugar, reduces doctor visits, normalization of HbA1c, HI, IR. Conclusions. IR is a protective reaction of the cells, preventing its oversaturation and overflow. Overweight is an independent risk factor for the development of T2DM and its clinical and laboratory manifestations. Targeted weight loss leads to disappearance of symptoms of HI, IR and T2DM.
Background: The impact of overweight and adipocyte size on the development of type 2 diabetes mellitus (T2DM) even remains unclear. Aim: To study: 1) the relationship between the state of adipocytes and/or overweight/obesity, the development of T2DM and its clinical and laboratory signs; 2) the effect of weight loss on glycemic level, hyperinsulinemia (HI), insulin resistance (IR), and T2DM status. Methods. Design: a systematic review. Settings: Web of Science, EBSCO, Scopus/ Science-Direct, Google Scholar, PubMed, Cochrane, и Wolter Kluwer were searched for articles published for 26 years (2000-2026). The study bases on a systematic review of 3853 articles published worldwide. Results. In total, 142 full-text articles were assessed for eligibility. With an increase in overweight, the size of adipose tissue increases, adipocytes increase, the cell radius increase. All it leads to an overload of intracellular transport and internal organs. Increase in cell size triggers intracellular mechanisms to limit further nutrient supply. When cell size increases excessively, conformational changes in cellular receptors are activated, resulting in the development of IR. The increase in cell size and the maximum accumulation of overweight, as parallel processes, lead to hyperglycemia and HI with gradual development of IR and T2DM. Any type of intentional weight loss leads to a decrease in IR, HI and the disappearance of T2DM. Targeted weight loss in patients with T2DM improves metabolic and cardiovascular health, reduces blood pressure and blood sugar, reduces doctor visits, normalization of HbA1c, HI, IR. Conclusions. IR is a protective reaction of the cells, preventing its oversaturation and overflow. Overweight is an independent risk factor for the development of T2DM and its clinical and laboratory manifestations. Targeted weight loss leads to disappearance of symptoms of HI, IR and T2DM.
Posted: 18 March 2026
Developing a Composite Street Livability Index for Commercial Streets in Indian Cities: A Case Study of T. Nagar (Thyagaraya Nagar), Chennai
M Senthil
,Jinu Louishidha Kitchley
Posted: 18 March 2026
RBFNN-Based Secure Tracking Control for a Class of Strict-Feedback Nonlinear Systems with Asymmetric Output Constraints and Its Application to UAVs
Lijun Zhang
,Meiru Jiang
,Jiahao Li
,Na Liu
,Jiyong Lu
,Kai Cui
Posted: 18 March 2026
Measuring Velocity Using Moving Clocks—The Surprising Test of Tangherlini’s Theory
Andrew Wutke
Posted: 18 March 2026
Application and Development of Aircraft Flyover Measurements in China
Haoyuan Dong
,Cheng Wei Lee
,Yuqi Zhou
,Wei Ma
Posted: 18 March 2026
Potassium Disorders in Pet Rabbits and Their Association with Glycemia, Azotemia, and Clinical Outcome
Maria Ardiaca
,Daniel Pinto
,Cristina Bonvehí
,Andrés Montesinos
Posted: 18 March 2026
Plant Species Effect on Soil Micronutrients and Aluminum in Secondary Forests at Masako Forest Reserve, Kisangani, Democratic Republic of Congo
Nsalambi V. Nkongolo
,Darceline A. Mokea
,Maria Luisa Fernandez-Marcos
Posted: 18 March 2026
Paracrine Signals from the Tumor Microenvironment Modulate Stem-Cell Collagen Interaction, Remodeling and Reprogramming Toward a Cancer-Associated Phenotype
Lora Topalova
,Tanya Stoyanova
,Nadia García-Parra
,José Luis Gómez Ribelles
,Svetla Todinova
,George Altankov
Posted: 18 March 2026
A Simplified Mechanical Model for Rocking Structures on Compliant Foundations
Baojun Yuan
,Mirjam Kloos
,Hamid Sadegh-Azar
Housner’s classical rocking model assumes a rigid base, often leading to inaccurate seismic assessments in real-world soil conditions. This study quantitatively establishes the applicability limits of the rigid-base assumption and defines a reference range for its validity. To bridge this gap, a novel Soil-Structure Interaction (SSI)-rocking model is formulated via the Lagrange Equation, capturing the coupled dynamics between rocking blocks and compliant foundations. Crucially, a closed-form relationship is derived to correlate the analytical model’s interface stiffness with the shear and Young’s moduli used in industrial finite element (FE) software. Our findings reveal that rocking behavior depends not only on soil stiffness but also on the inherent stiffness of the structure. Consequently, a relative stiffness parameter is introduced to bridge the analytical and numerical frameworks. Validation using LS-DYNA confirms the model’s precision across varying base stiffnesses. Results indicate that softer soils significantly alter rocking initiation thresholds and amplify peak angles. This proposed analytical model provides a computationally efficient, FE-compatible tool to improve stability predictions and design strategies for unanchored structures in earthquake-prone regions.
Housner’s classical rocking model assumes a rigid base, often leading to inaccurate seismic assessments in real-world soil conditions. This study quantitatively establishes the applicability limits of the rigid-base assumption and defines a reference range for its validity. To bridge this gap, a novel Soil-Structure Interaction (SSI)-rocking model is formulated via the Lagrange Equation, capturing the coupled dynamics between rocking blocks and compliant foundations. Crucially, a closed-form relationship is derived to correlate the analytical model’s interface stiffness with the shear and Young’s moduli used in industrial finite element (FE) software. Our findings reveal that rocking behavior depends not only on soil stiffness but also on the inherent stiffness of the structure. Consequently, a relative stiffness parameter is introduced to bridge the analytical and numerical frameworks. Validation using LS-DYNA confirms the model’s precision across varying base stiffnesses. Results indicate that softer soils significantly alter rocking initiation thresholds and amplify peak angles. This proposed analytical model provides a computationally efficient, FE-compatible tool to improve stability predictions and design strategies for unanchored structures in earthquake-prone regions.
Posted: 18 March 2026
Combined Bentall, Coronary Artery Bypass Grafting and Implantation of Ascyrus Medical Dissection Stent Landed Inside a Thoracic Endovascular Aortic Repair Stent
Robert Grant
,Pouya Nezafati
,Bruce French
Posted: 18 March 2026
Revisiting the Status of YF Epizootics and its Surveillance in South America: New Non-Human Primates, Spillover and Ecological Drivers
D. Katterine Bonilla-Aldana
,Jorge Luis Bonilla-Aldana
,Lysien Zambrano
,Alfonso J. Rodriguez-Morales
Posted: 18 March 2026
Machine Learning-Based Adaptive Time Series Momentum Strategies in Equity Index Futures: A Comparative Analysis Between S&P 500 and CSI 300 Futures Markets
Qiumei Li
,Xuwen Huang
,Ke Huang
,Zuominyang Zhang
Posted: 18 March 2026
Determinants of Managers’ Well-Being in Albania’s Lending Sector: A Study of Microfinance Institutions and Commercial Banks
Albana Boriçi
,Ardita Borici
,Arjola Halluni (Dergjini)
,Jetmir Muja
Posted: 18 March 2026
Smart Cities and Sustainable Low-Emission Transport? Bridging the Technology Gap for Environmentally Sustainable and Low-Emission EU Cities
Ivana Čermáková
Posted: 18 March 2026
Towards Greener Watermelon Production in China: From Regional Assessments to Field Optimization
Huanyu Zhao
,Yujia Li
,Yuheng Wang
,Jiawei Xie
,Yu Xu
,Deshui Tan
,Yueqiang Zhang
Posted: 18 March 2026
Sacred Architecture and Community Well-Being at the Chapel of the Resurrection, University of Ibadan
Adeola Ajayi
,Babafemi Gegesleso
Posted: 18 March 2026
The Job Characteristics Model in the Age of Large Language Models: A Multi-Architecture Analysis of AI-Augmented Work Design
Jonathan H. Westover
Posted: 18 March 2026
New Quantum Spin Perspective, Matter Waves and Uncertainty Principle
Rakshit P. Vyas
Posted: 18 March 2026
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