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Effect of Horizontal Angulation on Radiographic Measurement of the Contact Point–Alveolar Bone Crest Distance: An In Vitro Study
Sari A. Mahasneh
,Michaela Goodwin
,Joanne Cunliffe
Posted: 11 March 2026
The Effects of Climate Change and Tropical Cyclones on Offshore Wind Turbines in Nova Scotia
The Effects of Climate Change and Tropical Cyclones on Offshore Wind Turbines in Nova Scotia
Jerjis Kapra
,Larry Hughes
Nova Scotia, a province on Canada’s Atlantic coast, has proposed Wind West, a plan to initiate the province’s offshore wind industry. A regional offshore wind report identified eight potential development areas (PDAs), of which four were chosen. The areas were selected to avoid ecologically significant and conflict-of-use areas; however, no consideration was given to tropical cyclones (TCs) and hurricanes (intense tropical cyclones). This paper evaluates the effects of climate change and TCs on offshore wind turbines sighted on Nova Scotia’s continental shelf by analysing historical TC track data to assess the intensity and frequency of extreme wind and wave events on the continental shelf. Correlations between SSTs and extreme weather events were also examined. The findings show no clear long-term trends in TC intensity or frequency in the selected areas, although there is a clear upward trend in sea-surface temperatures (SSTs) since 1950. No strong correlation between rising SSTs and increased storm intensity or frequency within the available datasets were found, though similar studies suggest that these variables have some correlation on aggregate. While climate change is causing conditions for hurricanes to become favorable along the Scotian Shelf, current TC data shows no clear correlation with increasing intensity and frequency over time. The results are affected by the quality of the data. High uncertainty, spatial resolution, and temporal resolution leave large portions of TC tracks unmeasured. Uncertainty associated with pre- and post-1950 data makes conclusions from the results difficult. We propose a measuring buoy in each of the four selected potential development areas cost C$200,000 to develop and C$35,000 to maintain. Each buoy would have a representative radius of 50km, slightly larger than that of each of the four wind energy zones. The additional data collected would allow developers to pick appropriate design standards based on available environmental data and could additionally be used for climate change research. Currently, Nova Scotia faces many limitations developing its offshore; supplying accurate data to assess the risk from extreme weather events to offshore wind turbines is one of the first steps to ensuring success.
Nova Scotia, a province on Canada’s Atlantic coast, has proposed Wind West, a plan to initiate the province’s offshore wind industry. A regional offshore wind report identified eight potential development areas (PDAs), of which four were chosen. The areas were selected to avoid ecologically significant and conflict-of-use areas; however, no consideration was given to tropical cyclones (TCs) and hurricanes (intense tropical cyclones). This paper evaluates the effects of climate change and TCs on offshore wind turbines sighted on Nova Scotia’s continental shelf by analysing historical TC track data to assess the intensity and frequency of extreme wind and wave events on the continental shelf. Correlations between SSTs and extreme weather events were also examined. The findings show no clear long-term trends in TC intensity or frequency in the selected areas, although there is a clear upward trend in sea-surface temperatures (SSTs) since 1950. No strong correlation between rising SSTs and increased storm intensity or frequency within the available datasets were found, though similar studies suggest that these variables have some correlation on aggregate. While climate change is causing conditions for hurricanes to become favorable along the Scotian Shelf, current TC data shows no clear correlation with increasing intensity and frequency over time. The results are affected by the quality of the data. High uncertainty, spatial resolution, and temporal resolution leave large portions of TC tracks unmeasured. Uncertainty associated with pre- and post-1950 data makes conclusions from the results difficult. We propose a measuring buoy in each of the four selected potential development areas cost C$200,000 to develop and C$35,000 to maintain. Each buoy would have a representative radius of 50km, slightly larger than that of each of the four wind energy zones. The additional data collected would allow developers to pick appropriate design standards based on available environmental data and could additionally be used for climate change research. Currently, Nova Scotia faces many limitations developing its offshore; supplying accurate data to assess the risk from extreme weather events to offshore wind turbines is one of the first steps to ensuring success.
Posted: 11 March 2026
Comparative Stakeholder Sustainability Dynamics: EU-27 Countries (2015–2024)
Stefan Damyanov Petrov
Posted: 11 March 2026
Clinical Impact of Olaparib Dose Reduction Compared with Bevacizumab and Standard-Dose Olaparib in Platinum-Sensitive Recurrent Ovarian Cancer
Shunsuke Tatsuki
,Tadahiro Shoji
,Ami Jo
,Nanako Jonai
,Yohei Chiba
,Sho Sato
,Eriko Takatori
,Yoshitaka Kaido
,Takayuki Nagasawa
,Masahiro Kagabu
+3 authors
Objective: Bevacizumab (BEV) and Olaparib (OLA) have demonstrated clinical efficacy as maintenance therapies for first platinum-sensitive recurrent ovarian cancer. However, direct comparisons between these agents independent of homologous recombination deficiency (HRD) and BRCA status, remain limited and the clinical validity of OLA dose reduction has not yet been confirmed. This study aimed to compare the efficacy and safety of BEV, standard-dose OLA, and dose-reduced OLA as maintenance therapy and to evaluate the clinical utility of OLA dose reduction. Methods: This retrospective multicenter study included 101 patients with first platinum-sensitive recurrent ovarian, fallopian tube, or primary peritoneal cancer who received maintenance therapy after achieving a response to chemotherapy. Patients were classified into three groups: BEV (n = 34), standard-dose OLA (n = 31), and dose-reduced OLA (n = 36). The primary endpoint was progression-free survival (PFS), and secondary endpoints included overall survival (OS) and adverse events. Survival outcomes were evaluated using Kaplan–Meier analysis and Cox proportional hazards models. Results: Median PFS was 16 months in the BEV group, 16 months in the standard-dose OLA group, and 24 months in the dose-reduced OLA group, with significantly longer PFS in the dose-reduced OLA group (p < 0.001). In the multivariate Cox analysis, treatment remained an independent prognostic factor for PFS (HR 0.67, 95% CI 0.46–0.96, p = 0.030). Median OS was 44, 45, and 64 months, respectively, with no significant differences among groups; PFI ≥12 months was the only independent prognostic factor for OS. Grade ≥3 hematologic toxicities were more frequent in the OLA groups but were manageable. Conclusions: Dose-reduced OLA was associated with prolonged PFS while maintaining manageable toxicity, supporting its clinical validity as a maintenance option independent of HRD and BRCA status.
Objective: Bevacizumab (BEV) and Olaparib (OLA) have demonstrated clinical efficacy as maintenance therapies for first platinum-sensitive recurrent ovarian cancer. However, direct comparisons between these agents independent of homologous recombination deficiency (HRD) and BRCA status, remain limited and the clinical validity of OLA dose reduction has not yet been confirmed. This study aimed to compare the efficacy and safety of BEV, standard-dose OLA, and dose-reduced OLA as maintenance therapy and to evaluate the clinical utility of OLA dose reduction. Methods: This retrospective multicenter study included 101 patients with first platinum-sensitive recurrent ovarian, fallopian tube, or primary peritoneal cancer who received maintenance therapy after achieving a response to chemotherapy. Patients were classified into three groups: BEV (n = 34), standard-dose OLA (n = 31), and dose-reduced OLA (n = 36). The primary endpoint was progression-free survival (PFS), and secondary endpoints included overall survival (OS) and adverse events. Survival outcomes were evaluated using Kaplan–Meier analysis and Cox proportional hazards models. Results: Median PFS was 16 months in the BEV group, 16 months in the standard-dose OLA group, and 24 months in the dose-reduced OLA group, with significantly longer PFS in the dose-reduced OLA group (p < 0.001). In the multivariate Cox analysis, treatment remained an independent prognostic factor for PFS (HR 0.67, 95% CI 0.46–0.96, p = 0.030). Median OS was 44, 45, and 64 months, respectively, with no significant differences among groups; PFI ≥12 months was the only independent prognostic factor for OS. Grade ≥3 hematologic toxicities were more frequent in the OLA groups but were manageable. Conclusions: Dose-reduced OLA was associated with prolonged PFS while maintaining manageable toxicity, supporting its clinical validity as a maintenance option independent of HRD and BRCA status.
Posted: 11 March 2026
Global Food Price Dynamics, Undernourishment and Human Development: Wavelet Coherence Evidence and SDG 2.1 Resilience Scenarios to 2030
Olena Pavlova
,Oksana Liashenko
,Kostiantyn Pavlov
,Agata Kutyba
,Nataliia Fastovets
,Artur Machno
,Oleksandr Holubiev
,Tetiana Vlasenko
Posted: 11 March 2026
Pre-Biotic Earth and a More Complete Theory of Heat Transformation, Part II – Chemical Dissipative Structures and Networks
Lee G. Irons
Posted: 11 March 2026
Conceptual Model of Stage-Dependent Transition in Rheumatoid Arthritis: A Threshold Framework for Ultra-Early Intervention
Jun Fukae
,Yoshiharu Amasaki
Posted: 11 March 2026
The Gateway to Parallel Universe & Connected Physics
Deep Bhattacharjee
,Onwuka Frederick
,Riddhima Sadhu
,Susmita Bhattacharjee
,Shounak Bhattacharya
,Soumendra Nath Thakur
,Priyanka Samal
,Pallab Nandi
,Tarun Bhattacharjee
,Sanjeevan Singha Roy
+2 authors
Posted: 11 March 2026
Investment Cascades and Fitness Capital
Douglas Roy
Posted: 11 March 2026
Generalization of Convolution
Leon Cohen
Posted: 11 March 2026
Cang-ai Volatile Oil Ameliorates Chronic Unpredictable Mild Stress-Induced Depression-Like Symptoms in Rats by Regulating NT/Trk Signaling Pathway
Mingqin Shi
,Haimei Zhou
,Xiangdian Xiao
,Chengting Jiang
,Lei Pan
,Xiaoman Lv
,Tengfei Qian
,Dongdong Qin
Posted: 10 March 2026
Total Vitamin B12 and Holotranscobalamin: Current Evidence, Limitations, and Clinical Utility
Martina Marandola
,Giulia Napoli
,Simone Leggeri
,Carla Lombardi
,Andrea Urbani
,Silvia Baroni
Posted: 10 March 2026
Serum Protein Profiling of Patients at Risk to Develop Gastric Disease Based on a DSC Test
Ombretta Repetto
,Filippo Sperti
,Mariangela De Zorzi
,Stefano Realdon
,Agostino Steffan
,Renato Cannizzaro
,Valli De Re
Posted: 10 March 2026
Adolescent Mental Health and Health-Related Behaviors Across Language-Based School Systems in South Tyrol, Italy
Christian J. Wiedermann
,Verena Barbieri
,Giuliano Piccoliori
,Doris Hager von Strobele Prainsack
Posted: 10 March 2026
EPANG-Gen: A Robust Curvature-Aware Optimizerwith Uncertainty Quantification for Scientific Machine Learning
Mohsen Mostafa
Posted: 10 March 2026
Rheology of Non-Dilute Emulsions: A Comprehensive Review
Rajinder Pal
Posted: 10 March 2026
Mechanical Thrombectomy in Mild Acute Ischaemic Stroke with Large Vessel Occlusion: A Systematic Review [Protocol]
Alan Silburn
,Namita Singh
Posted: 10 March 2026
Theoretical Analysis of the Effect of Angle of Attack on Lift and Drag of a Generic Wing
Kisara Vishvadinu Kasthuriarachchi
Posted: 10 March 2026
Conservation and Dynamic Recombination of Spacetime Units: A Unified Framework for Gravity, Cosmology, and Quantum Discreteness
Hongliang Qian
,Yixuan Qian
This paper proposes a gravitational theoretical framework based on the dynamics of discrete spacetime units. The core idea is that there exists a conserved ”spacetime raw material”, and quan- tum virtual processes of matter continuously produce new spacetime units by consuming this raw material, forming local density gradients—which manifest as spacetime curvature. This mechanism naturally eliminates action-at-a-distance, is compatible with general relativity under covariance con- straints, and provides a unified explanation for dark matter, dark energy, black hole singularities, and other long-standing puzzles.First, we clarify the meta-principle of ”global common covariance”, and on this basis, give the ultimate explanation of symmetry breaking: symmetry is not ”broken”, but a local cost paid for global covariance. Then we systematically elaborate twelve core arguments of the framework, and starting from the only fundamental equation (the second-order discrete wave equation of complex fields), we rigorously and step-by-step derive the Newtonian gravity limit, mass-energy equation E = mc2 , the principle of constant speed of light, Maxwell’s equations, Newton’s three laws, Schr¨odinger equation, Dirac equation, the origin of spin-1/2, and the geometric formula of the fine-structure constant. All physical laws are derived results rather than external inputs. Finally, we present quantitative predictions that can be tested by future experiments.
This paper proposes a gravitational theoretical framework based on the dynamics of discrete spacetime units. The core idea is that there exists a conserved ”spacetime raw material”, and quan- tum virtual processes of matter continuously produce new spacetime units by consuming this raw material, forming local density gradients—which manifest as spacetime curvature. This mechanism naturally eliminates action-at-a-distance, is compatible with general relativity under covariance con- straints, and provides a unified explanation for dark matter, dark energy, black hole singularities, and other long-standing puzzles.First, we clarify the meta-principle of ”global common covariance”, and on this basis, give the ultimate explanation of symmetry breaking: symmetry is not ”broken”, but a local cost paid for global covariance. Then we systematically elaborate twelve core arguments of the framework, and starting from the only fundamental equation (the second-order discrete wave equation of complex fields), we rigorously and step-by-step derive the Newtonian gravity limit, mass-energy equation E = mc2 , the principle of constant speed of light, Maxwell’s equations, Newton’s three laws, Schr¨odinger equation, Dirac equation, the origin of spin-1/2, and the geometric formula of the fine-structure constant. All physical laws are derived results rather than external inputs. Finally, we present quantitative predictions that can be tested by future experiments.
Posted: 10 March 2026
Words and Numbers: A Dynamical Systems Perspective
Stefano Isola
,Francesco Marchionni
Posted: 10 March 2026
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