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Relationships Between PM2.5 and Maternal Anemia in Sub-Saharan African Women of Reproductive Age
Muhammad A Saeed,
Harris Khokhar,
Mohammad R Saeed,
Adeena Zaidi,
Binish Arif Sultan,
Sarim Karimi,
Ammar Muhammad,
Harris Majeed,
Bhargavi Rao
Posted: 14 November 2025
Epidemiology Meets Advocacy: Understanding Pediatric Dental Trauma and Delayed Care in Post-Conflict Syria
Yasser Alsayed Tolibah,
Nada Bshara,
Rama E. Makieh,
Marwan Alhaji,
Mohammed N. Al-Shiekh,
MHD Bashier AlMonakel,
Osama Aljabban,
Ziad D. Baghdadi
Posted: 14 November 2025
Deep Learning for Tumor Segmentation and Multiclass Classification in Breast Ultrasound Images Using Pretrained Models
K. E. Arun Kumar,
Matthew E Wilson,
Nathan E Blake,
Tylor J Yost,
Matthew Walker
Posted: 14 November 2025
Ambient Temperatures and Anemia Among Women of Reproductive Age in South Asia
Muhammad A Saeed,
Bhargavi Rao,
Mohammad R Saeed,
Xaviera Ayaz,
Aleena Fatima,
Mohammad Usman,
Vatsal Vermuri,
Uzair Mohammad,
Binish Arif Sultan,
Harris Majeed
Posted: 14 November 2025
Parental Stress in Parents of Children with Autism Spectrum Disorder
Dolores Merino-Navarro,
María-del-Rocío Martínez-López,
Emilia-Isabel Martins-Teixeira-da-Costa,
María Ángeles Merino-Godoy,
Francisco Javier Gago-Valiente
Posted: 14 November 2025
Beyond Disability Scores: The Provocative Truth of Psychosocial Resilience in Battling MS Quality of Life in Western Greece
Christina Ravazoula,
Constantinos Koutsojannis
Posted: 14 November 2025
Pharmaceutical Development in Nepal and a Comparative Critical Review of the Nepal Pharmacy Council Act (2000)
Bishesh Bista,
Nisha Adhikari,
Dirgha Raj Joshi
Posted: 14 November 2025
What to Know About Falls in Older Adults? Risk Factors, Predictors, and Therapeutic Interventions
Fernanda Bueno Pilastri,
Julia Fantim Lopes,
Eric Nkansah Boateng,
Nise Ribeiro Marques
Posted: 14 November 2025
Oral Health and Quality of Life of Pediatric Patients with Complex Chronic Conditions
Willian Brito Sampaio,
Luanderson Lopes,
Ana Rita Guimarães Duarte,
Maria Cristina Teixeira Cangussu,
Andreia Cristina Leal Figueiredo
Posted: 14 November 2025
Examining Gender Differences and Their Associations Among Psychosocial Distress, Social Support, and Financial Well-Being of Informal Caregivers of Older Adults
Nasreen Lalani,
Evans Appiah Osei,
Zihan Xu
Posted: 14 November 2025
Clinical Outcomes of Shochwave Therapy in Lipedema
Hatice Durmuş,
Türkan Akbayrak,
Sergio Gianesini,
Suat Doğancı
Background: Lipedema is a chronic condition whose public awareness and detection is constantly growing, yet without strongly validated therapeutic opportunities. Objectives: Given the need to direct lipedema patients toward appropriate management approaches and the demand for new studies and methods, this invetigation aimed to assess the effects of a combined treatment consisting of extracorporeal shock wave therapy (ESWT), manual lymphatic drainage (MLD), intermittent pneumatic compression (IPC), and lifestyle recommendations compared to a 5-week control period prior to treatment in patients with lipedema. Methods: Retrospective evaluation of patients undergoing a 5-week control period with lifestyle recommendations followed by a 5-week treatment period (10 sessions) with a standardized protocol including ESWT, MLD and IPC. Circumference measurements at three designated points on the lower extremities were recorded at the start and end of the control period, and before and after treatment. Results: Data from 55 female patients (age: 46.9 ± 11.9 years, body mass index [BMI]: 29.54 ± 7.33 kg/m²) who completed both the control and treatment periods were included. Analysis of measurement changes over time showed significant improvements in 3 of 6 measured points during the control period, with no significant changes at other levels. In contrast, significant improvements were observed at all levels after treatment (p < 0.01). Conclusion: The combined use of ESWT, MLD, IPC, and lifestyle recommendations was found to be an effective method for managing lipedema treatment. Further studies on the relative impact of each and everyone of these 3 therapeutic components are encouraged.
Background: Lipedema is a chronic condition whose public awareness and detection is constantly growing, yet without strongly validated therapeutic opportunities. Objectives: Given the need to direct lipedema patients toward appropriate management approaches and the demand for new studies and methods, this invetigation aimed to assess the effects of a combined treatment consisting of extracorporeal shock wave therapy (ESWT), manual lymphatic drainage (MLD), intermittent pneumatic compression (IPC), and lifestyle recommendations compared to a 5-week control period prior to treatment in patients with lipedema. Methods: Retrospective evaluation of patients undergoing a 5-week control period with lifestyle recommendations followed by a 5-week treatment period (10 sessions) with a standardized protocol including ESWT, MLD and IPC. Circumference measurements at three designated points on the lower extremities were recorded at the start and end of the control period, and before and after treatment. Results: Data from 55 female patients (age: 46.9 ± 11.9 years, body mass index [BMI]: 29.54 ± 7.33 kg/m²) who completed both the control and treatment periods were included. Analysis of measurement changes over time showed significant improvements in 3 of 6 measured points during the control period, with no significant changes at other levels. In contrast, significant improvements were observed at all levels after treatment (p < 0.01). Conclusion: The combined use of ESWT, MLD, IPC, and lifestyle recommendations was found to be an effective method for managing lipedema treatment. Further studies on the relative impact of each and everyone of these 3 therapeutic components are encouraged.
Posted: 13 November 2025
Neutrophil Extracellular Traps in Systemic Lupus Erythematosus: Pathogenic Mechanisms, Crosstalk with Oxidative Stress, and Antioxidant Therapeutic Potential
Xi Chen,
Danni Gao,
Lisheng Wang,
Matthew Wang,
Chengping Wen,
Honghua Hu,
Yujun Tang
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder marked by autoantibody production and immune complex (IC) formation, leading to widespread inflammation and tissue damage. Neutrophil extracellular traps (NETs) — web-like structures of DNA, histones, and antimicrobial proteins — support innate immunity but drive SLE pathogenesis when dysregulated. This review examines SLE-specific NET mechanisms, their crosstalk with oxidative stress, and their therapeutic potential as antioxidants. SLE patients exhibit excessive NET formation, driven by proinflammatory low-density granulocytes (LDG) and ICs, and impaired NET clearance (reduced DNase1/DNase1L3 activity or anti-nuclease autoantibodies), leading to circulating NET accumulation. These NETs act as autoantigen reservoirs, forming pathogenic NET–ICs that amplify autoimmunity. Oxidative stress (via NADPH oxidase) and various mitochondrial reactive oxygen species (ROS) promote NETosis; antioxidants (both enzymatic and non-enzymatic) can inhibit NET formation by scavenging ROS or blocking NADPH oxidase. Preclinical studies show that curcumin, resveratrol, and mitochondrial-targeted MitoQ reduce NETs and lupus nephritis; clinical trials confirm that curcumin and N-acetylcysteine (NAC) lower SLE activity and proteinuria, supporting their potential as safe adjuvant therapies. However, high-dose vitamin E may exacerbate autoimmunity. Future research should clarify NET mechanisms in SLE and optimize antioxidant therapies (e.g., bioavailability, safe dosage and long-term safety).
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder marked by autoantibody production and immune complex (IC) formation, leading to widespread inflammation and tissue damage. Neutrophil extracellular traps (NETs) — web-like structures of DNA, histones, and antimicrobial proteins — support innate immunity but drive SLE pathogenesis when dysregulated. This review examines SLE-specific NET mechanisms, their crosstalk with oxidative stress, and their therapeutic potential as antioxidants. SLE patients exhibit excessive NET formation, driven by proinflammatory low-density granulocytes (LDG) and ICs, and impaired NET clearance (reduced DNase1/DNase1L3 activity or anti-nuclease autoantibodies), leading to circulating NET accumulation. These NETs act as autoantigen reservoirs, forming pathogenic NET–ICs that amplify autoimmunity. Oxidative stress (via NADPH oxidase) and various mitochondrial reactive oxygen species (ROS) promote NETosis; antioxidants (both enzymatic and non-enzymatic) can inhibit NET formation by scavenging ROS or blocking NADPH oxidase. Preclinical studies show that curcumin, resveratrol, and mitochondrial-targeted MitoQ reduce NETs and lupus nephritis; clinical trials confirm that curcumin and N-acetylcysteine (NAC) lower SLE activity and proteinuria, supporting their potential as safe adjuvant therapies. However, high-dose vitamin E may exacerbate autoimmunity. Future research should clarify NET mechanisms in SLE and optimize antioxidant therapies (e.g., bioavailability, safe dosage and long-term safety).
Posted: 13 November 2025
Expanding Horizons: Host Range Evolution and Treatment Strategies for Highly Pathogenic H5N1 Avian Influenza
Nika Heydari Gazik,
Mark Holodniy,
Vafa Bayat
Posted: 13 November 2025
Antibiotic Resistance and Virulence Mechanisms in Klebsiella pneumoniae: Understanding for Better Interventions
Assefa Asnakew Abebe,
Alemayehu Godana Birhanu,
Tesfaye Sisay Tessema
Klebsiella pneumoniae is a prominent pathogen implicated in a wide range of infections, including pneumonia, urinary tract infections, and septicemia. Its ability to acquire and disseminate antibiotic resistance, coupled with the rising prevalence of hypervirulent strains, represents a significant public health threat. Understanding the molecular basis of drug resistance can guide the design and development of effective treatment strategies. Antimicrobial resistance (AMR) in these bacteria is a complicated process and cannot be attributed to only a single resistance mechanism. K. pneumoniae develops resistance to antibiotics through a variety of mechanisms, ranging from single molecular mechanisms to complex interactions, where molecular synergy exacerbates resistance. This review summarizes the current understanding of the molecular mechanisms that contribute to the drug resistance and virulence of this pathogen. Key antibiotic resistance mechanisms include drug inactivation via B-lactamases and carbapenemases, membrane remodeling, efflux pump systems, such as AcrAB-TolC and OqxAB, and biofilm formation facilitated by quorum sensing. Additionally, the role of ribosomal changes in resistance was highlighted. This review also examines the mechanisms of virulence, emphasizing fimbriae, iron acquisition systems, and immune evasion strategies. Understanding these mechanisms of drug resistance and virulence is crucial for remodeling existing antibiotics and developing new therapeutic strategies.
Klebsiella pneumoniae is a prominent pathogen implicated in a wide range of infections, including pneumonia, urinary tract infections, and septicemia. Its ability to acquire and disseminate antibiotic resistance, coupled with the rising prevalence of hypervirulent strains, represents a significant public health threat. Understanding the molecular basis of drug resistance can guide the design and development of effective treatment strategies. Antimicrobial resistance (AMR) in these bacteria is a complicated process and cannot be attributed to only a single resistance mechanism. K. pneumoniae develops resistance to antibiotics through a variety of mechanisms, ranging from single molecular mechanisms to complex interactions, where molecular synergy exacerbates resistance. This review summarizes the current understanding of the molecular mechanisms that contribute to the drug resistance and virulence of this pathogen. Key antibiotic resistance mechanisms include drug inactivation via B-lactamases and carbapenemases, membrane remodeling, efflux pump systems, such as AcrAB-TolC and OqxAB, and biofilm formation facilitated by quorum sensing. Additionally, the role of ribosomal changes in resistance was highlighted. This review also examines the mechanisms of virulence, emphasizing fimbriae, iron acquisition systems, and immune evasion strategies. Understanding these mechanisms of drug resistance and virulence is crucial for remodeling existing antibiotics and developing new therapeutic strategies.
Posted: 13 November 2025
The Impact of Online Health Platform Engagement on Patient Attitudes Toward Treatments for Atrial Fibrillation: A Mediated Model of Threat Perception and Behavioral Evaluation
Myrthe F. Kuipers,
Joey R.F.N. Snel,
Mellanie T. Hills,
Bianca JJM Brundel,
Umut Konus
Posted: 13 November 2025
Challenges of Childhood Obesity and its Effect on Mental Health
Elina Sahoo,
Prasant Jena
Posted: 13 November 2025
The E1/E2 Paradox: Trillions Spent, 45 Years Later, Why Is the Tropical Food System Functionally Worse?
Marco Ruggiero,
Carlo Nicastro
Posted: 13 November 2025
Assessing Adolescents’ Awareness of the Health Risks Associated with Energy Drink Consumption
Muhammad Zeeshan Rub
Posted: 13 November 2025
Factors Associated with Dietary Diversity of Children Aged 24–59 Months in Urban-Rural Areas of Kinshasa, 2024: A Community Based Cross-Sectional Study
Din-ar Bopete Batuli,
Mélissa Bokomba Kusisakana,
Berthold Matondo Bondo,
Emérite Bisita Disuemi,
Richard Ma Eloko Makaba,
Yanick Jobalo Matata,
Éric Mopasola Emox,
Steve Botomba Ntambwe,
Paulin Mutombo Beya
Posted: 13 November 2025
Developing a Public Health Quality Tool for Mobile Health Clinics to Assess and Improve Care
Nancy E Oriol,
Josephina Lin,
Jennifer Bennet,
Darien DeLorenzo,
Mary Kathryn Fallon,
Delaney Gracy,
Caterina Hill,
Madge Vasquez,
Anthony Vavasis,
Mollie Williams
+1 authors
Posted: 13 November 2025
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