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Preprint ARTICLE | doi:10.20944/preprints202209.0426.v1

Association Between Insertion-Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene and Treatment Response to Antipsychotic Medications: A Study of Antipsychotic-Naïve First-Episode Psychosis Patients and Nonadherent Chronic Psychosis Patients

Sergej Nadalin, Sanja Dević Pavlić, Vjekoslav Peitl, Dalibor Karlović, Lena Zatkovic, Smiljana Ristić, Alena Buretić-Tomljanović, Hrvoje Jakovac

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: angiotensin-converting enzyme (ACE); antipsychotic medication; polymorphism, insertion/deletion; treatment response

Online: 28 September 2022 (03:12:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0307.v1

Training on Emotional Intelligence for Caregivers of Patients with Acquired Brain Injury and Cognitive Impairment: A Quasi-Experimental Study

Irene De-Torres, Fernando Bustos, Juan Carlos Arango-Lasprilla, Pablo Fernández-Berrocal

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: emotional intelligence; brain injury; cognitive impairment

Online: 20 September 2022 (13:14:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0278.v1

Facebook and Suicidal Behaviour: User Experiences of Suicide Notes, Live-streaming, Grieving and Preventive Strategies. A Scoping Review.

Sheikh Shoib, Miyuru Chandradasa, Mahsa Nahidi, Tan Weiling Amanda, Sonia Khan, Fahimeh Saeed, Sarya Swed, Marianna Mazza, Marco Di Nicola, Giovanni Martinotti, Massimo Di Giannantonio, Aishatu Yusha’u Armiya’u, Domenico De Berardis

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Suicide attempt; behaviour; prevention; Facebook

Online: 19 September 2022 (10:33:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0268.v1

Impact of COVID-19 Lockdowns on the Activity and Mental Health of Older People in Indonesia: A Qualitative Study

Nelsensius Klau Fauk, Ernawati , Elsa Dent, Gregorius Abanit Asa, Paul Russell Ward

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19 outbreak; lockdown protocols; individual and social activities; mental health challenges; older people; Indonesia

Online: 19 September 2022 (07:51:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0265.v1

‘I doubt myself and am losing everything I have since COVID came’- The Case Study of Mental Health and Coping Strategies among Undocumented Myanmar Migrant Workers in Thailand

Tual Sawn Khai, Muhammad Asaduzzaman

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: mental health; migrant health; undocumented migrants; COVID-19; coping strategy; Myanmar; Thailand; mixed method

Online: 19 September 2022 (05:40:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0228.v1

Resting-State Functional Connectivity Impairment in Patients With the Major Depressive Episode

Drozdstoy Stoyanov, Vladimir Khorev, Rossitsa Paunova, Sevdalina Kandilarova, Denitsa Simeonova, Artem Badarin, Semen Kurkin, Alexander Hramov

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: functional connectivity; functional magnetic-resonance imaging; resting state; mood disorders; classification

Online: 15 September 2022 (09:20:26 CEST)

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Aim. In the current study, we aimed at identifying resting-state brain networks, which are different in patients with depression compared to healthy individuals. Moreover, we analyzed the potential for clinical use of different network measures that could discriminate the two groups and thus help the diagnostic process. Method and subjects. We recruited 90 subjects: 49 healthy controls (HC) and 41 patients with a major depressive episode (MDE). All subjects underwent clinical evaluation and functional resting-state MRI. The data were processed to investigate functional connectivity network measures across the two groups using Brain Connectivity Toolbox. The statistical inferences were made at the functional networks level, using false discovery rate method. Independent samples t-test was performed on the network measures mean values to reveal differences between HC and MDE groups. Permutation-based statistical testing was used to test the significance of the difference between the distributions of the network measures by nodes for HC and MDE groups. Linear discriminant analysis was used to differentiate between the groups. Results and discussion. Significant differences in FC between depressed patients and healthy controls were found with the most prominent changes encompassing within-region as well as between-region connectivity of occipital lobe areas such as precuneus (PreCu), cuneus (Cu), superior occipital gyrus (SOG), lingual gyrus (LG), fusiform gyrus (FG), cerebellum, along with limbic structures including the hippocampus (Hipp) and cingulate gyrus. Linear discriminant analysis demonstrated that the full connectivity matrices, as well as those with only the significant connections identified in advance, were the most precise in differentiating between depression and health. These measures reached precision levels of 97% and 94%, respectively. Conclusion. Our study delivered further evidence about impairment of functional connectivity networks in MDE that may contribute to differentiate patients with depression from healthy subjects.

Preprint ARTICLE | doi:10.20944/preprints202209.0213.v1

Interaction Between Participation and Impact of a Multicomponent Empowerment-based Psychosocial Mental Health Intervention on Service Users and Their Relatives

Francisco José Eiroa-Orosa, Maria Jesús San Pío, Gemma Marcet, Isabela Sibuet, Emilio Rojo

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: community care; integrated care; mental health; service users and relatives’ interventions; service users and relatives’ interaction

Online: 14 September 2022 (16:27:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0121.v1

Effects of Cathinones (Bath Salts) On Cultured Primary Neurons/Astroglia Cells and Neurobehavioral Functions in Mice

Tyler M. Selig, Kevin Pierre, Rawad Daniel Arja, Abeer Dagra, Mark Gold, Vijaya Raghavan, Firas Kobeissy, Zhihui Yang, Kevin K. W. Wang

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Cathinones; Designer drugs; Bath salts; Neuronal injury; astroglial injury; Calpain; Caspase

Online: 8 September 2022 (09:14:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0110.v1

The Link between ADHD and Antisocial Behavior: The Moderating Role of the Protective Factor Sense of Coherence

Haym Dayan, Mona Khoury-Kassabri, Yehuda Pollak

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: ADHD; Antisocial Behavior; Sense of Coherence; Protective Factors

Online: 7 September 2022 (11:03:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0069.v1

E2F4DN Transgenic Mice: A Tool for the Evaluation of E2F4 as a Therapeutic Target in Neuropathology and Brain Aging

Morgan Ramón-Landreau, Cristina Sánchez-Puelles, Noelia López-Sánchez, Anna Lozano-Ureña, Aina M. Llabrés-Mas, José M. Frade

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: acetylated E2F4; synapsis; tissue homeostasis; Alzheimer’s disease; 5xFAD mice; neuroinflammation; microgliosis; reactive astrocytes.

Online: 5 September 2022 (13:52:27 CEST)

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E2F4 was initially described as a transcription factor with a key function in the regulation of cell quiescence. Nevertheless, a number of recent studies have established that E2F4 can also play a relevant role in cell and tissue homeostasis as well as tissue regeneration. For these non-canonical functions, E2F4 can also act in the cytoplasm, where it is able to interact with many homeostatic and synaptic regulators. Since E2F4 is expressed in the nervous system, it may fulfill a crucial role in brain function and homeostasis, being a promising multifactorial target for neurodegenerative diseases and brain aging. The regulation of E2F4 is complex as it can be chemically modified through acetylation, from which we present evidence in the brain, as well as methylation, and phosphorylation. The phosphorylation of E2F4 within a conserved threonine motif induces cell cycle re-entry in neurons, while a dominant negative form of E2F4 (E2F4DN), in which the conserved threonines have been substituted by alanines, has been shown to act as a multifactorial therapeutic agent for Alzheimer’s disease (AD). We have generated transgenic mice neuronally expressing E2F4DN. We have recently shown using this mouse strain that expression of E2F4DN in 5xFAD mice, a known murine model of AD, improved cognitive function, reduced neuronal tetraploidization, and induced a transcriptional program consistent with modulation of amyloid-beta (Abeta) peptide proteostasis and brain homeostasis recovery. 5xFAD/E2F4DN mice also showed reduced microgliosis and astrogliosis in both cerebral cortex and hippocampus at 3-6 months of age. Here we have analyzed the immune response in 1 year-old 5xFAD/E2F4DN mice, concluding that reduced microgliosis and astrogliosis is maintained at this late stage. In addition, the expression of E2F4DN also reduced age-associated microgliosis in wild-type mice, thus stressing its role as a brain homeostatic agent. We conclude that E2F4DN transgenic mice represent a promising tool for the evaluation of E2F4 as a therapeutic target in neuropathology and brain aging.

Preprint ARTICLE | doi:10.20944/preprints202208.0458.v1

Beyond the Penrose Hypothesis: Examining the Association between the Availability of Psychiatric Care and National Homicide Rates in 166 Countries

Ravi Philip Rajkumar

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: mental illness; homicide; violence; psychiatry; Penrose hypothesis; deinstitutionalization

Online: 26 August 2022 (10:00:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0391.v1

Workplace Assessment Scale: Pilot Validation Study

Eileen Huang, Nicole E. Edgar, Sarah E. MacLean, Simon Hatcher

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: scale design; reliability; validity; first responders; mental health; workplace; occupational stress; humiliation; betrayal

Online: 23 August 2022 (03:50:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0355.v1

A Comprehensive Study of De Novo Mutations on Protein-protein Interaction Interface Provides New Insights in Developmental Delay

Dhruba Tara Maharjan, Weichen Song, Zhe Liu, Weidi Wang, Wenxiang Cai, Jue Chen, Fei Xu, Weihai Ying, Guan Ning Lin

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: developmental delay; de novo mutation; protein-protein interaction; PPI interface; protein in-teractome; PsymuKB

Online: 19 August 2022 (04:50:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0344.v1

The Mental Health of Young Return Migrants with Ancestral Roots in Their Destination Country: A Cross-Sectional Study Focusing on the Ethnic Identities of Japanese-Brazilian High School Students Living in Japan

Eriko Fukui, Takashi Uchino, Masunari Onozaka, Takashi Kawashimo, Momoko Iwai, Youji Takubo, Akiko Maruyama, Sachio Miura, Ryo Sekizaki, Masafumi Mizuno, Naoyuki Katagiri, Naohisa Tsujino, Takahiro Nemoto

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: ethnic identity; mental health; migrant; transcultural psychiatry; youth

Online: 18 August 2022 (10:58:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0341.v1

An Integrative Analysis Identified Schizophrenia-Associated Brain Cell Types and Gene Expression Changes

Wenxiang Cai, Weichen Song, Zhe Liu, Dhruba Tara Maharjan, Jisheng Liang, Guan Ning Lin

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Schizophrenia; cell types proportions; differential expression genes; functional pathways; CIBERSORTx

Online: 18 August 2022 (10:54:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0297.v1

The Impact of Foehn Wind on Mental Distress among Patients in a Swiss Psychiatric Hospital

Christian A. Mikutta, Charlotte Pervilhac, Hansjörg Znoj, Andrea Federspiel, Thomas J Müller

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: foehn wind; psychopathology; BSCL; mental health; weather; meteorological factors; climate change

Online: 17 August 2022 (04:04:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0227.v1

Differences in the Course of depression and anxiety After COVID-19 Infection Between Recovered Patients With and Without a Psychiatric History: A Cross-Sectional Study

Megumi Hazumi, Kentaro Usuda, Emi Okazaki, Mayumi Kataoka, Daisuke Nishi

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; depression; anxiety; post-acute COVID-19 syndrome; post-COVID

Online: 12 August 2022 (04:56:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202208.0180.v1

A Systematic Review of Recreational Nitrous Oxide Use: Implications for Policy, Service Delivery and Individuals

Julaine Allan, Jacqui Cameron, Juliana Bruno

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Nitrous Oxid; N₂O; nangs; systematic review; harm reduction; drug use

Online: 9 August 2022 (11:29:40 CEST)

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Background Nitrous Oxide (N₂O) is a dissociative anaesthetic that is sometimes used recreationally. The prevalence of N₂O use is difficult to quantify but appears to be increasing. Research on N₂O harms and application of harm reduction strategies are limited. The aim of this mixed method systematic review was to collate and synthesise the disparate body of research on recreational nitrous oxide use to inform harm reduction approaches tailored for young people. Methods To identify publications reporting recreational use of N₂O, a search of public health, psychology and social science databases was conducted. Databases included PubMed, CIHNAL, PsycINFO, Scopus and Web of Science. Gray literature and Google advanced search were also used. Due to limited published literature on the recreational use of N₂O, no limit was placed on publication date or study type. A thematic synthesis extracted descriptive and analytical themes from the selected studies. Quality appraisal was conducted using the CASP Tool for Qualitative studies and the Joanna Briggs Institute case report assessment tool Results The search retrieved 407 reports. Thirty-four were included in the final analysis including sixteen case reports. The included studies were primarily concerned with raising awareness of the apparently increasing use and subsequently increasing harms of recreational N₂O use. There was limited reference to policy or legislative responses in any published studies, no suggestions for harm reduction strategies or application of service level responses. In general, individuals lack awareness of N2O related harms. Conclusion The review found three key areas that deserve further consideration including: 1) policy, 2) service delivery, and 3) harm associated with N₂O use. We recommend a top-down (policy) and bottom-up (services delivery/services users) approach to harm reduction for N₂O use which also includes further consultation and research with both groups. Future research could explore young people’s experience of N₂O use including benefits and problems to inform contextually relevant harm reduction strategies.

Preprint ARTICLE | doi:10.20944/preprints202208.0178.v1

A Genome-Wide Association Study Reveals New Genes in a Molecular Network Associated With Alcohol Dependence and Related Clinical Measures

Anastasia Levchenko, Sergey Malov, Alexey Antonik, Anastasia Protsvetkina, Kseniya V. Rybakova, Alexander Kanapin, Alexey N. Yakovlev, Anna Y. Nenasteva, Anton E. Nikolishin, Nikolay Cherkasov, Natalia A. Chuprova, Anna S. Blagonravova, Angelica V. Sergeeva, Tatyana V. Zhilyaeva, Maria K. Denisenko, Raul R. Gainetdinov, Alexander O. Kibitov, And Evgeny M. Krupitsky

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: alcohol dependence; comorbidity; gene network; genome-wide association study; sex differences

Online: 9 August 2022 (10:35:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0219.v1

Human-Induced Pluripotent Stem Cell Technology: Toward the Future of Personalized Psychiatry

Alessandra Alciati, Angelo Reggiani, Daniela Caldirola, Giampaolo Perna

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: personalized psychiatry; psychiatric disorders; induced pluripotent stem cells; brain organoids

Online: 14 July 2022 (11:46:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0130.v1

Mitochondrial Impairment: A Common Motif in Neuropsychiatric Presentation? The Link to the Tryptophan-Kynurenine Metabolic System

Masaru Tanaka, Ágnes Szabó, Eleonóra Spekker, Helga Polyák, Fanni Tóth, And László Vécsei

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Keywords: mitochondria; stress resilience; plasticity; stress; kynurenine; Alzheimer’s disease; neurodegenerative; depression; anxiety; psychiatric

Online: 8 July 2022 (03:56:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0079.v1

Immersive Therapy for Improving Anxiety in Health Professionals of a Regional Hospital During the COVID-19 Pandemic: A Quasi-Experimental Pilot Study

Marta Linares-Chamorro, Neus Domènech-Oller, Javier Jerez-Roig, Joel Piqué-Buisan

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Virtual reality; health professionals; anxiety; immersive therapy

Online: 5 July 2022 (16:01:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0064.v1

Pharmacotherapy for the Secondary Prevention of Suicide: Leads from the Social Pain Hypothesis

Ravi Philip Rajkumar

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: suicide; social pain; psychache; endogenous opioid system; oxytocin; serotonin; endocannabinoids; buprenorphine; psilocybin; ketamine

Online: 5 July 2022 (07:43:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0395.v1

Effectiveness of Agreement Criteria and Flows of Collaborative Care in Primary Mental Health Care in Brazil

Valdecir Carneiro da Silva, Ardigleusa Alves Coelho, Ana Angélica Rêgo de Queiroz, Gabriela Maria Cavalcanti Costa, João Carlos Alchieri, Ricardo Alexandre Arcêncio, Severina Alice da Costa Uchôa

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Mental Health; Primary Health Care; Collaborative Care; Health Assessment

Online: 29 June 2022 (05:05:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0296.v1

Storyboarding HIV Infected Young People’s Adherence to Antiretroviral Therapy in Lower to Upper Middle-Income Countries: A New-Materialist Qualitative Evidence Synthesis

Lynn A Hendricks, Taryn Young, Susan Van Wyk, Catharina Matheï, Karin Hannes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: new materialism; assemblage; storyboarding; HIV; adherence; antiretroviral therapy; young people; perinatal infection; qualitative evidence synthesis; biopsychosocial

Online: 21 June 2022 (10:54:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0004.v1

The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: a Systematic Review and Meta-Analysis

Sarah Houben, Bruno Bonnechère

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Long-COVID; cognitive disorders; rehabilitation

Online: 1 June 2022 (05:50:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0413.v1

Routine Use of Financial Capacity Instruments for Clinical Decisional Capacity Testing: A Scoping Review

Eduard P. Drima

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: financial capacity instruments; Semi-Structured Clinical Interview for Financial Capacity; deci-sional capacity; mild cognitive impairment; gamification

Online: 31 May 2022 (07:37:21 CEST)

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Financial capacity instruments are psychometric tools designed to evaluate individual decisional capacity based on financial decisions. As tests are complex and need special conditions for administration and evaluation, it is difficult to use them in daily geriatric clinics. Our scoping review objective was to evaluate existing financial capacity instruments from the perspective of simplicity and portability. We evaluated one English speaking knowledge database (Medline) using a dedicated MeSH terminology. The review yielded one independent instrument, The Semi-Structured Clinical Interview for Financial Capacity, that can be easy adapted for every-day clinical use. It is simple to understand and perform and do not need trained personnel for administration. It can be finalized in 15 minutes. Initially validated on 261 subjects (with different forms of cognitive impairment), it showed good accuracy and precision mainly in subjects with cognitive impairment. The test is less apt to detect early or fluctuating cognitive impairment. Simplicity, the main advantage of the test, allows gamification fact that increases portability. Familiar images (coins, money) that are used for performing simple tasks does not need complex translation and adaptation. In form of a game, the test is suitable for serial administration, increasing the chance for early capacity reduction detection. Results reflect a physician judgement related to the subjects’ capacity to understand and execute simple financial instructions and not financial proficiency scores. The main limitation of our review is that we investigated only one, English speaking, knowledge database. The scoping strategy generated a financial capacity instrument that can be used in geriatric clinics for early diagnostic of decisional capacity reduction. Further studies are needed to evaluate the reliability and validity of the test in conditions of serial administration and in populations having various financial experience.

Preprint ARTICLE | doi:10.20944/preprints202205.0409.v1

Are There Sex Differences in Self-Reported Childhood Maltreatment in Major Depressive and Bipolar Disorders? A Retrospective Cross-Sectional Study

Daniela Caldirola, Tatiana Torti, Francesco Cuniberti, Silvia Daccò, Alessandra Alciati, Koen Schruers, Giovanni Martinotti, Domenico De Berardis, Giampaolo Perna

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: childhood trauma; major depressive disorder; bipolar disorder; sex difference; age

Online: 31 May 2022 (03:39:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0291.v2

Reductions in Anxiety, Depression and Insomnia in Health Care Workers Using a Non-pharmaceutical Intervention

Katherine Currie B.S., Babu V. Gupta, Ishan Shivanand, Amit Desai, Shweta Bhatt, Hari S. Tunuguntla, Sadhna Verma

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Yoga of Immortals (YOI); depression; healthcare workers; insomnia; anxiety; PHQ-8 (Pa-tient Health Questionnaire-8); ISI (Insomnia Severity Index); digital health

Online: 24 May 2022 (04:49:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0291.v1

Reductions in Anxiety, Depression and Insomnia in Health Care Workers using a non-pharmaceutical intervention

Katherine Currie B.S., Babu V. Gupta, Ishan Shivanand, Amit Desai, Shweta Bhatt, Hari S. Tunuguntla, Sadhna Verma

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Yoga of Immortals (YOI); depression, healthcare workers; insomnia; anxiety; PHQ-8 (Pa-tient Health Questionnaire-8); ISI (Insomnia Severity Index); digital health

Online: 23 May 2022 (10:07:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0160.v1

Analysis of Phenolic Compounds in Parkinson’s Disease: A Bibliometric Assessment of the 100 Most Cited Papers

José Messias Perdigão, Bruno José Brito Teixeira, Daiane Claydes Baia-da-Silva, Priscila Cunha Nascimento, Rafael Rodrigues Lima, Hervé Rogez

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Bibliometric; Parkinson’s Disease; Phenolic compound

Online: 12 May 2022 (07:58:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0144.v1

Predicting Remission among Perinatal Women with Depression in Rural Pakistan: A Prognostic Model for Task-Shared Interventions in Primary Care Settings

Ahmed Waqas, Siham Sikander, Abid Malik, Najia Atif, Eirini Karyotaki, Atif Rahman

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Perinatal depression; prognosis; prognostic modeling; nomogram; Pakistan

Online: 10 May 2022 (15:40:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0121.v1

Discrepancy between Desired Time in Bed and Desired Total Sleep Time in Patients with Cancer: The DBST Index and the Relationship with Insomnia Severity or Sleep Onset Latency

Eulah Cho, Jaeeun Song, Joohee Lee, Inn-Kyu Cho, Dongin Lee, Hayun Choi, Harin Kim, Seockhoon Chung

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: cancer; insomnia; sleep; circadian; the DBST index

Online: 13 April 2022 (08:36:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0327.v1

Memory Enhancement with Kynurenic Acid and its Mechanisms in Neurotransmission

Diána Martos, Bernadett Tuka, Masaru Tanaka, László Vécsei, Gyula Telegdy

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: tryptophan; kynurenine; kynurenic acid; passive avoidance; cognitive domain; memory; cognitive enhancer; neurotransmission; receptor blockers; translational

Online: 24 March 2022 (08:57:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0279.v1

The Pathways to Participation (P2P) Program: A Pilot Outcomes Study

Danielle Hitch, Lindsay Vernon, Rachel Collins, Carolyn Dun, Sarah Palexas, Kate Lhuede

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: recovery; mental illness; mental health; psychiatry; social inclusion; occupational therapy; occupations; time use; activities of daily living; work.

Online: 21 March 2022 (08:56:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0257.v1

Cautionary Observations Concerning the Introduction of Psychophysiological Biomarkers into Neuropsychiatric Practice

Paul E. Rapp, Christopher Cellucci, David Darmon, David Keyser

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: biomarkers; electroencephalography; event related potentials; heart rate variability; diagnosis; sensitivity; specificity

Online: 17 March 2022 (15:19:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0191.v1

Alcohol Consumption, Loneliness, Quality of Life, Social Media Usage, and General Anxiety Before and During the COVID-19 Pandemic in Singapore

Mengieng Ung, Kalista Yearn Yee Wan, Shi Yu Liu, Ying Jie Choo, Nathaniel Shan Wei Liew, Zhexuan Azure Shang, Sophie Su Hui Khoo, Wei Xuan Tay, Ruixi Lin, Siyan Yi

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; pandemic; GAD-7; mental health; quality of life; Asia

Online: 14 March 2022 (16:20:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0099.v1

Use of Long-Acting Injectable Antipsychotics in Inpatients with Schizophrenia Spectrum Disorder in an Academic Psychiatric Hospital in Switzerland

Stephan Reymann, Georgios Schoretsanitis, Stephan T. Egger, Alexey Mohonko, Matthias Kirschner, Stefan Vetter, Philipp Homan, Erich Seifritz, Achim Burrer

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: long-acting injectable; antipsychotic; depot; schizophrenia spectrum disorder; schizophrenia; schizoaffective; inpatient; prescribing pattern

Online: 7 March 2022 (12:33:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0156.v2

Ketamine as a Novel Psychopharmacotherapy for Eating Disorders: Evidence and Future Directions

Anya Ragnhildstveit, Matthew Slayton, Laura Jackson, Madeline Brendle, Sachin Ahuja, Willis Holle, Claire Moore, Kellie Sollars, Paul Seli, Reid Robison

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: esketamine; ketamine; ketamine assisted psychotherapy; eating disorder; anorexia nervosa; bulimia nervosa; binge eating disorder; pharmacology; psychedelics; treatment

Online: 7 March 2022 (08:34:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0062.v1

Sickness Behaviour and Depression: An Updated Model of Peripheral-Central Immunity Interactions

Federico Turkheimer, Mattia Veronese, Valeria Mondelli, Diana Cash, Carmine Pariante

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Major depression; inflammation; sickness behaviour; mechanism; model; microglia; zcitokynes; CRP; blood brain barrier; choroid plexus

Online: 3 March 2022 (10:28:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0285.v1

Bullied Because of Their Teeth: Evidence from a Longitudinal Study on the Impact of Oral Health on Bullying Victimization Among Australian Indigenous Children

Md Irteja Islam, Verity Chadwick, Tuguy Esgin, Alexandra Martiniuk

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Bullying; Oral health; Indigenous; Children; Australia

Online: 23 February 2022 (05:26:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0167.v1

Positive Mental Health in University Students and Its Relations with Psychological Vulnerability, Mental Health Literacy and Sociodemographic Characteristics: A Descriptive-Correlational Study

Sónia Teixeira, Carme Ferré-Grau, Carlos Alberto Sequeira, Regina Pires, José Carlos Carvalho, Isilda Ribeiro, Carolina Sequeira, Teresa Rodrigues, Francisco Sampaio, Tiago Costa, Maria Teresa Lluch i Canut

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: mental health; mental health literacy; psychological vulnerability; health promotion; adult

Online: 11 February 2022 (21:40:28 CET)

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Resumo: Este estudo teve como objetivo avaliar a Saúde Mental Positiva (SPM) e a sua relação com características sociodemográficas, literacia em saúde mental e escala de vulnerabilidade psicológica (PVS) em estudantes universitários portugueses com idades compreendidas entre os 17 e os 62 anos. Foi realizado um estudo descritivo-correlacional. Uma pesquisa online foi realizada para avaliar variáveis demográficas, e vários questionários foram aplicados para avaliar saúde mental positiva, vulnerabilidade psicológica e alfabetização em saúde mental. Os dados foram coletados de 1º de novembro de 2019 a 1º de setembro de 2020. No geral, 3.405 alunos participaram do estudo. Os resultados mostram que 67,8% dos alunos revelaram um alto nível de PMH, 31,6% apresentaram um nível médio de PMH e 0,6% apresentaram um nível baixo de PMH. Os estudantes do sexo masculino relataram maior satisfação pessoal (t (3170) = -2,39, p=0,017) e autonomia (t (3170) = -3,33, p=0,001), no PMH em relação ao sexo feminino. Alunos sem bolsa pontuaram mais alto (t (3.127) = -2,04, p=0,42) no PMH do que alunos com bolsa. Estudantes que não foram deslocados de casa relataram maior (t (3170) = -1,99, p=0,047) Autocontrole em PMH do que aqueles deslocados de sua casa. Estudantes universitários com resultados de PMH mais altos têm resultados de PVS mais baixos e resultados de Alfabetização mais altos. Os achados deste estudo contribuirão para identificar as necessidades de intervenção dos alunos na PMH. Estudantes universitários com resultados de PMH mais altos têm resultados de PVS mais baixos e resultados de Alfabetização mais altos. Os achados deste estudo contribuirão para identificar as necessidades de intervenção dos alunos na PMH. Estudantes universitários com resultados de PMH mais altos têm resultados de PVS mais baixos e resultados de Alfabetização mais altos. Os achados deste estudo contribuirão para identificar as necessidades de intervenção dos alunos na PMH.

Preprint REVIEW | doi:10.20944/preprints202202.0156.v1

Ketamine as a Novel Psychopharmacotherapy for Eating Disorders: Evidence and Future Directions

Anya Ragnhildstveit, Matthew Slayton, Laura Jackson, Madeline Brendle, Sachin Ahuja, Willis Holle, Claire Moore, Kellie Sollars, Paul Seli, Reid Robison

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: esketamine; ketamine; ketamine assisted psychotherapy; eating disorder; anorexia nervosa; bulimia nervosa; binge eating disorder; pharmacology; psychedelics; treatment

Online: 11 February 2022 (04:30:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0124.v1

Analysis of the Coping Strategies of Primary Health Care Professionals: Cross-Sectional Study in a Large Brazilian Municipality

Luciano Garcia Lourenção, Bruno Martinez Rigino, Natalia Sperli Geraldes Marin dos Santos Sasaki, Maria Jaqueline Coelho Pinto, Franciso Rosemiro Guimarães Ximenes Neto, Flávio Adriano Borges Melo, Maria de Lourdes Sperli Geraldes Santos, José Gustavo Monteiro Penha, Daniela Menezes Galvão, Betânia Maria Pereira dos Santos, Isabel Cristina Kowal Olm Cunha, Jacqueline Flores de Oliveira, Max dos Santos Afonso, Carlos Leonardo Figueiredo Cunha, Francielle Garcia da Silva, Neyson Pinheiro Freire, Vagner Ferreira do Nascimento, Sidiane Teixeira Rodrigues, Taisa Moitinho de Carvalho, Messias Lemos, Juliana Lima da Cunha, Neide Aparecida Micelli Domingos

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: primary health care; family health strategy; health personnel; adaptation; psychological

Online: 8 February 2022 (16:23:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0447.v1

Application of Mass Multivariate Analysis on Neuroimaging Data Sets in Psychiatric Diagnostics

Rositsa Paunova, Sevdalina Kandilarova, Anna Todeva-Radneva, Adeliya Latypova, Ferath Kherif, Drozdstoy Stoyanov

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: mass multivariate analysis; neuroimaging, depression, schizophrenia

Online: 31 January 2022 (11:07:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0134.v1

The Tryptophan Catabolite or Kynurenine Pathway’s Role in Major Depression

Abbas F. Almulla, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: TRYCATs; MDD; MDE; Suicidal behavior; Kynurenine pathway

Online: 11 January 2022 (10:39:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0080.v2

Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study

Matthew J. Hoptman, Umit Tural, Kelvin O. Lim, Daniel C. Javitt, Lauren E. Oberlin

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: DTI; resting state; schizophrenia; FATCAT; tractography

Online: 5 January 2022 (10:35:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0374.v1

An Explainable Machine Learning Approach for COVID-19 Impact on Mood State of Children and Adolescents during the 1st Lockdown in Greece

Charis Ntakolia, Dimitrios Priftis, Mariana Charakopoulou-Travlou, Ioanna Rannou, Konstantina Magklara, Ioanna Giannopoulou, Konstantinos Kotsis, Aspasia Serdari, Emmanouil Tsalamanios, Aliki Grigoriadou, Konstantina Ladopoulou, Iouliani Koullourou, Neda Sadeghi, Georgia O’Callaghan, Argyris Stringaris, Eleni Lazaratou

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19 pandemic; children and adolescents; machine learning; post-hoc explainability; model calibration

Online: 22 December 2021 (16:21:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0301.v1

The Tryptophan Catabolite or Kynurenine Pathway in Schizophrenia: Meta-Analysis Reveals Dissociations Between Central, Serum and Plasma Compartments

Abbas F. Almulla, Asara Vasupanrajit, Chavit Tunvirachaisakul, Hussein K. Al-Hakeim, Marco Solmi, Robert Verkerk, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Schizophrenia; indoleamine-dioxygenase; inflammation; neuro-immune; oxidative and nitrosative stress; biomarkers

Online: 20 December 2021 (09:56:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0256.v1

Analysis of Clinical Parameters, Drug Consumption and Use of Health Resources in a Southern European Population with Alcohol Abuse Disorder During COVID-19 Pandemic

Ana Lear-Claveras, Beatriz González-Álvarez, Sabela Couso-Varela, Ana Clavería, Bárbara Oliván-Blázquez

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; lockdown; primary care; lifestyle; health resources.; alcohol abuse desorder

Online: 15 December 2021 (14:47:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0083.v1

Psychological Distress among Bangladeshi Dental Students during the COVID-19 Pandemic

Farah Sabrina, Mohammad Tawfique Hossain Chowdhury, Sujan Kanti Nath, Ashik Abdullah Imon, S M Abdul Quader, Md Shahed Jahan, Ashek Elahi Noor, Clopa Pina Podder, Unisha Gainju, Rina Niroula, Muhammad Aziz Rahman

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Psychological distress; Fear; Coping; COVID-19; Bangladesh; Dental; Mental health

Online: 6 December 2021 (15:22:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0080.v1

Relationships between Diffusion Tensor Imaging and Resting State Functional Connectivity in Patients with Schizophrenia and Healthy Controls: A Preliminary Study

Matthew J. Hoptman, Umit Tural, Kelvin O. Lim, Daniel C. Javitt, Lauren E. Oberlin

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: DTI; resting state; schizophrenia; FATCAT; tractography

Online: 6 December 2021 (15:16:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0554.v1

Metabolic Syndrome in Patients of a Psychosocial Care Center in Brazil: A Cross-Sectional Study

Dandara Almeida Reis da Almeida Reis da Silva, Ludmila Santana de Almeida, Livia Lugarinho Correa, Rodrigo Fernandes Weyll Pimentel, Antonio Marcos Tosoli Gomes, Ana Gabriela Travassos, Adriana Mattos Viana, Monique Monique Magnavita Borba da Fonseca Cerqueira, Marcio Costa de Souza, Anderson Reis de Sousa, Paulo José Bastos Barbosa, Julita Maria Freitas Coelho, Lucelia Batista Neves Cunha Magalhães, Argemiro D’Oliveira Júnior, Jorge Lopes Cavalcante Neto, Charles Souza Santos, Luiz Carlos Moraes França, Juliana de Lima Brandão, Livia Fajin de Mello dos Santos, Helena Ferraz Gomes, Ellen Marcia Peres, Thais Regis Aranha Rossi, Kairo Silvestre Meneses Damasceno, Magno Conceição das Merces

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Metabolic syndrome; Mental disorders; Obesity; Multimorbidity

Online: 30 November 2021 (10:38:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0507.v2

Depression and Autoimmune Thyroiditis - Their Relationship and the Effects of Treating Psychiatric and Thyroid Disorders on Changes in Clinical and Biochemical Parameters Including BDNF and Other Cytokines

Zofia Kotkowska, Dominik Strzelecki

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depression; chronic autoimmune thyroiditis; BDNF

Online: 29 November 2021 (12:03:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0442.v1

Psychological Distress in Men During the COVID-19 Pandemic in Brazil: The Role of the Sociodemographic Variables, Uncertainty and Social Support

Anderson Reis de Sousa, Jules Ramon Brito Teixeira, Waandererson Carneiro Moreira, Milena Bitencourt Santos, Herica Emilia Félix de Carvalho, Éric Santos Almeida, Raíssa Millena Silva Florencio, Aline Macêdo de Queiroz, Magno Conceição das Merces, Tilson Nunes Mota, Isabella Félix Meira Araújo, Josielson Costa da Silva, Sélton Diniz dos Santos, Emerson Lucas Silva Camargo, Luciano Garcia Lourenção, Richardson Silva, Evanilda Souza de Santana Carvalho, Iracema Lua, Sônia Barros, Tânia Maria de Araújo, Márcia Aparecida Ferreira De Oliveira, Álvaro Pereira, Wilson Abreu, Carlos Alberto Sequeira

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Men's Health; COVID-19; Mental Disorders; Stress, Psychological; Social Support

Online: 24 November 2021 (08:13:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0323.v1

Development and Validation of a Questionnaire to Measure Association Factors with Suicide

Juliano Flávio Rubatino Rodrigues, Spencer Payão, Hannes Fischer

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Suicide; questionnaire; validity; reliability

Online: 18 November 2021 (11:17:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0219.v1

Eight-Year Retrospective Study of Young Adults in a Diabetes Transition Clinic

Aarooran Sritharan, Uchechukwu Levi Osuagwu, Manjula Ratnaweera, David Simmons

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Diabetic Ketoacidosis; Mental health; Type 1 diabetes; Transition; Glycemia

Online: 12 November 2021 (12:04:43 CET)

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The transition of people from paediatric to adult diabetes services is associated with worsening glycaemia and increased diabetes-related hospitalisation. This study compared the clinical characteristics of those with and without mental health conditions among attenders at a diabetes young adult clinic diabetes before and after changes in service delivery. Retrospective review of 200 people with diabetes attending a Sydney public hospital over eight years corresponding to the period before (2012-2016) and after (2017-2018) restructuring of a clinic for young adults aged 16-25 years. Characteristics of those with and without mental health conditions (depression, anxiety, diabetes related distress, eating disorders), were compared. Among clinic attenders (type 1 diabetes n=184, 83.2%), 40.5% (n=89) had a mental health condition particularly, depression (n=57, 64%), which was higher among Indigenous than non-Indigenous people (5.6% vs 0.8% p=0.031) but similar between diabetes type. Over eight years, those with, compared with those without a mental health condition had higher HbA1c at the last visit (9.4%[79 mmol/mol] vs 8.7% [71 mmol/mol], p=0.027), the proportion with diabetic ketoacidosis (DKA 60.7% vs 42.7%,p=0.009), smoking (38.4 vs 13.6%,p=0.009), retinopathy (9.0 vs 2.3%,p=0.025), multiple DKAs (28.4 vs 16.0%,p=0.031) were significantly higher. Having a mental health condition was associated with 2.02 (95% Confidence intervals 1.1-3.7) fold increased risk of HbA1c ≥ 9.0%[75mmol/mol]. Changes to the clinic were not associated with improvements in mental health condition (39.0% vs 32.4%, p=0.096). In conclusion, we found that mental health conditions, particularly depression, are common in this population and are associated with diabetes complications. Diabetes type and clinic changes did not affect the reported mental health conditions. Additional strategies are required to reduce complication risks among those with mental health conditions. .

Preprint ARTICLE | doi:10.20944/preprints202111.0121.v1

MTHFD1 1958 G>A Genetic Polymorphism (rs2236225) Dichotomy in Schizophrenia: Lower Manifestation Risks, but More Severe Negative Symptoms

Tatiana Zhilyaeva, Oksana Chekanina, Grigory Rukavishnikov, Anna Blagonravova, Galina Elevna Mazo

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: schizophrenia; MTHFD1 1958 G> A; folate metabolism; methylation; tetrahydrobiopterin

Online: 5 November 2021 (12:51:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0384.v1

Combined in silico, ex vivo, and in vivo Assessment of L-17, a Thiadiazine Derivative With Putative Neuroprotective and Antidepressant-Like Effects

Alexey Sarapultsev, Pavel Vassiliev, Daniil Grinchii, Alexander Kiss, Mojmír Mach, Jana Osacká, Alexandra Balloova, Ruslan Paliokha, Andrey N. Kochetkov, Larisa Sidorova, Petr Sarapultsev, Oleg Chupakhin, Maxim Rantsev, Pavel Vassiliev, Eliyahu Dremencov

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: thiadizines; serotonin transporter (SERT); serotonin-1A receptor; serotonin-3 receptor; docking; docking energy; binding affinity; binding mechanism; c-Fos; immunohistochemistry; electrophysiology

Online: 26 October 2021 (12:32:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0372.v1

Decreased Emotional Dysregulation Following Multi-modal Motion-assisted Memory Desensitization and Reprocessing Therapy (3MDR): Identifying Driving Factors in Remediation of Treatment-Resistant PTSD

Emily Tang, Chelsea Jones, Lorraine Smith-MacDonald, Matthew R.G. Brown, Eric H.G.J. Vermetten, Suzette Bremault-Phillips

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: 3MDR; treatment-resistant PTSD; military; veterans; mental health; emotional regulation

Online: 26 October 2021 (09:51:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints202110.0232.v1

The Neurobiology of Autism Spectrum Disorder As It Relates to Twice Exceptionality

Rachel Sharkey, Thomas Nickl-Jockschat

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: twice exceptionality; autism spectrum disorder; neuroimaging; MRI

Online: 15 October 2021 (16:17:13 CEST)

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Working Paper ARTICLE

Genome-Wide Study Suggests an Association of the Enhancer rs10419198 for PRR12 Gene with Disordered Eating Behavior in the Mexican Population

José Jaime Martínez-Magaña, Sandra Hernandez, Ana Rosa Garcia, Valeria Cardoso-Barajas, Emmanuel Sarmiento, Beatriz Camarena, Alejandro Caballero, Laura Gonzalez, Jorge Ameth Villatoro-Velazquez, Maria Elena Medina-Mora, Marycarmen Bustos-Gamiño, Clara Fleiz-Bautista, Carlos Alfonso Tovilla-Zarate, Isela Esther Juárez-Rojop, Humberto Nicolini, Alma Delia Genis-Mendoza

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: feeding and eating disorder; genome-wide association study; methylation quantitative trait loci

Online: 8 October 2021 (14:23:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0500.v2

The Mediating Role of Gender, Age, COVID-19 Symptoms and Changing of Mansion on the Mental Health of Healthcare Workers Operating in Italy during the First Wave of the COVID-19 Pandemic

Eleonora Gambaro, Carla Gramaglia, Debora Marangon, Danila Azzolina, Manuela Probo, Marco Rudoni, Patrizia Zeppegno

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: burnout; healthcare workers; mediation analysis; covid-19 pandemic; mental health

Online: 1 October 2021 (14:50:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0500.v1

The Mediating Role of Gender, Age, COVID-19 Symptoms and Changing of Mansion on the Mental Health of Healthcare Workers Operating in Italy during the First Wave of the COVID-19 Pandemic

Eleonora Gambaro, Carla Gramaglia, Debora Marangon, Danila Azzolina, Manuela Probo, Marco Rudoni, Patrizia Zeppegno

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: burnout; healthcare workers; mediation analysis; covid-19 pandemic; mental health

Online: 29 September 2021 (15:20:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0449.v1

Is There a Glutathione Centered Redox Dysregulation Subtype of Schizophrenia?

Lena Palaniyappan, Min Tae M. Park, Peter Jeon, Roberto Limongi, Kun Yang, Akira Sawa, Jean Théberge

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: glutathione; glutamate; psychosis; schizophrenia; redox; antioxidant; oxidative stress; myelin; spectroscopy

Online: 27 September 2021 (12:47:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0397.v1

The Story of Life’s Quality of Patients with Hypertentions and Its Complication

Amelia Rumi, Rudi Safarudin, Ririen Hardani, Dwi She Dewi Melinency, Nur Indah Sari, Khildayanti S, Lilies Handayani, Nurulhuda Rahman, Ismail Setyopranoto, Sitti Rahmawati

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Hypertension management; Complications of cardiovascular; Quality of Life

Online: 23 September 2021 (09:03:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0201.v1

Aberrations in the Cross-Talks Among Redox, Nuclear Factor-κB and Wnt/Catenin Pathway Signaling Underpin Myalgic Encephalomyelitis andChronic Fatigue Syndrome: A Review and New Hypothesis Based on Results of Network, Enrichment and Annotation Analyses

Michael Maes, Marta Kubera, Magdalena Kotańska

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: chronic fatigue syndrome; Myalgic Encephalomyelitis; inflammation; neuro-immune; oxidative and nitrosative stress; antioxidants

Online: 13 September 2021 (10:57:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0159.v1

Inflammation and Nitro-Oxidative Stress in Current Suicidal Attempts and Current Suicidal Ideation: a Systematic Review and Meta-Analysis

Asara Vasupanrajit, Ketsupar Jirakran, Chavit Tunvirachaisakul, Marco Solmi, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: suicide; neuro-immune; inflammation; oxidative and nitrosative stress; depression; mood disorders; schizophrenia; psychiatry

Online: 8 September 2021 (20:03:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0070.v1

New Drug Targets to Prevent Death due to Stroke: Results of Protein-Protein Interaction Network, Enrichment and Annotation Analyses.

Michael Maes, Nikita Nikiforov, Kitiporn Plaimas, Apichat Suratanee, Edna Maria Reiche

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: stroke; inflammation; neuro-immune; cytokines; hemostasis; coagulation; protein-protein interactions

Online: 3 September 2021 (15:11:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0037.v1

Hygiene Behavior in Face of the Corona Pandemic: Compliance Rates and Associations With Fear, SARS-COV-2 risk, Mental Health and Disability

Sonia Lippke, Franziska M. Keller, Christina Derksen, Lukas Kötting, Alina Dahmen

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; disability; risk factors; communication; medical rehabilitation; psychosomatic patients; general public; infection; physical health; psychological health

Online: 2 September 2021 (12:08:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0456.v1

Effective Connectivity between Major Nodes of the Limbic System, Salience and Frontoparietal Networks Differentiates Schizophrenia and Mood Disorders from Healthy Controls

Sevdalina Kandilarova, Drozdstoy Stoyanov, Rositsa Paunova, Anna Todeva-Radneva, Katrin Aryutova, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: psychiatry; effective connectivity; depression; salience network; schizophrenia; mood disorders

Online: 23 August 2021 (14:57:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0423.v1

One-Year Prospective Study of Occupational Health in the Intensivists of a COVID-19 Hub Hospital

Nicola Magnavita, Paolo Maurizio Soave, Massimo Antonelli

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: longitudinal study; emergency; infectious disease; organizational justice; stress; loneliness; compassion fatigue; meditation; prayer; insomnia; mental health; anaesthetists

Online: 23 August 2021 (10:22:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0369.v1

Gut Hormones as Potential Therapeutic Targets or Biomarkers of Response in Depression: The Case of Motilin

Ravi Philip Rajkumar

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depression; gut-brain axis; motilin; serotonin; gamma-aminobutyric acid; gonadal hormones; hypothalamic-pituitary-thyroid axis; antidepressants; macrolide antibiotics

Online: 18 August 2021 (07:39:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0320.v1

Exploring Clinical Correlates of Metacognition in Bipolar Disorders Using Moderation Analyses: The Role of Antipsychotics

Paul Roux, Nathan Faivre, Anne-Sophie Cannavo, Eric Brunet-Gouet, Christine Passerieux

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: bipolar disorders; metacognition; cognitive complaints; cognition; antipsychotic; impulsivity

Online: 16 August 2021 (11:03:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0665.v1

Influence of Sociodemographic, Economic and Employment-Related Factors on Sick Leave Due To Mental Illness. A Retrospective Study in an Industrialized Region in Southern Europe

Fernando Fuertes-Guiro, Carmen Marqués-Gaspar, Ajda Amet, Luis Fernández-Bengoa

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Sick leave; mental illness; predictors, prevention

Online: 27 May 2021 (11:36:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0091.v1

Tired, Worried and Burned Out But Still Resilient: A Cross-Sectional Study of Mental Health Workers During the Covid-19 Pandemic

Sofia Pappa, Joshua Barnett, Ines Berges, Nikolaos Sakkas

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; healthcare workers; United Kingdom; mental health; burnout; resilience; insomnia; depression; anxiety; lifestyle

Online: 5 April 2021 (10:24:40 CEST)

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The burden of COVID-19 pandemic on health systems and the physical and mental health of healthcare workers (HCWs) has been substantial. This cross-sectional study aims to assess the effects of Covid-19 on the psychological wellbeing of mental health workers who provide care to a vulnerable patient population that have been particularly affected during this crisis. A total of 387 HCWs from across a large urban mental health service completed a self-administered questionnaire consisting of socio-demographic, lifestyle and work-based information and validated psychometric scales. Depression and anxiety were measured using the Patient Health Questionnaire (PHQ-9) and the Generalized Anxiety Disorder Scale (GAD-7) respectively, sleep problems with the Athens Insomnia Scale (AIS), burnout with the Maslach Burnout Inventory (MBI) and resilience with the Resilience Scale-14 (RS-14). Multivariable logistic regression analysis was performed to determine potential mediating factors. Prevalence of burnout was notable, with 52% recording moderate/severe in Emotional Exhaustion, 19.5% moderate/severe in Depersonalisation and 55.5% low/moderate Personal Accomplishment. Over half of all respondents (52%) experienced sleep problems; the presence of depressive symptoms was a significant predictor of insomnia. An increase in potentially harmful lifestyle changes, such as smoking, alcohol consumption and over-eating was also observed. However, high Resilience was reported by 70% of the sample and the importance of this is highlighted. Female gender was associated with increased levels of depression and emotional exhaustion while those with a history of mental health conditions were most at risk of affective symptoms, insomnia and burnout. Overall, our study revealed considerable levels of psychological distress and maladaptive coping strategies but also resilience and satisfaction with organizational support provided. Findings can inform tailored interventions in order to mitigate vulnerability and prevent long-term psychological sequelae.

Preprint REVIEW | doi:10.20944/preprints202012.0625.v3

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Science in Mood and Anxiety Disorders

Lehel Balogh, Masaru Tanaka, Nóra Török, László Vécsei, Shigeru Taguchi

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depression; anxiety disorders; existential psychotherapy; logotherapy; meaning-centered psychotherapy; functional magnetic resonance imaging; biomarker; kynurenines; Martin Heidegger; Viktor Frankl

Online: 24 March 2021 (13:18:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0625.v2

Crosstalk between Existential Phenomenological Psychotherapy and Neurological Science in Mood and Anxiety Disorders

Lehel Balogh, Masaru Tanaka, Nóra Török, László Vécsei, Shigeru Taguchi

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depression; anxiety disorders; existential psychotherapy; logotherapy; meaning-centered psychotherapy; functional magnetic resonance imaging; biomarker; kynurenines; Martin Heidegger; Viktor Frankl

Online: 17 March 2021 (11:11:25 CET)

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Working Paper ARTICLE

‘An Apple A Day’?: Psychiatrists, Psychologists and Psychotherapists Report Poor Literacy for Nutritional Medicine: International Survey Spanning 52 Countries

Sabrina Mörkl, Linda Stell, Diana V Buhai, Melanie Schweinzer, Jolana Wagner-Skacel, Christian Vajda, Sonja Lackner, Susanne A Bengesser, Theresa Lahousen-Luxenberger, Annamaria Painold, Andreas Oberascher, Josef M Tatschl, Matthäus Fellinger, Annabel Mueller-Stierlin, Ana C Serban, Joseph Ben-Sheetrit, Ana-Marija Vejnovic, Mary I Butler, Vicent Balanza-Martinez, Nikola Zaja, Polona Rus-Prelog, Robertas Strumila, Scott B Teasdale, Eva Z Reininghaus, Sandra J Holasek

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Nutritional Psychiatry; Mental Health Professionals; Psychiatrists; Psychologists; Psychotherapists; Education; Psychiatric Disorders; Diet; Supplements; Nutrition

Online: 16 February 2021 (13:36:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0194.v1

From Recession to Depression? Prevalence and Correlates of Depression, Anxiety, Traumatic Stress and Burnout in Healthcare Workers During the COVID-19 Pandemic in Greece: A Multi-Center, Cross-Sectional Study

Sofia Pappa, Nikolaos Athanasiou, Nikolaos Sakkas, Stavros Patrinos, Elpitha Sakka, Zafeiria Barmparessou, Stamatoula Tsikrika, Andreas Adraktas, Athanasia Pataka, Ilias Migdalis, Sofia Gida, Paraskevi Katsaounou

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; health care workers; Greece; mental health; depression; anxiety; traumatic stress; burnout

Online: 8 February 2021 (11:41:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0087.v2

Adiposity in Depression or Depression in Adiposity? the Role of Immune-Inflammatory-Microbial Overlap

Oliwia Gawlik-Kotelnicka, Dominik Strzelecki

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depression; metabolic syndrome; non-alcoholic fatty liver disease; hypothalamic-pituitary-adrenal axis; inflammation; oxidative stress; microbiota

Online: 8 January 2021 (10:16:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0754.v1

Impact of Service User Video Presentations on Explicit and Implicit Stigma toward Mental Illness among Medical Students in Nepal: A Randomized Controlled Trial

Cori L. Tergesen, Dristy Gurung, Saraswati Dhungana, Ajay Risal, Prem Basel, Dipesh Tamrakar, Archana Amatya, Lawrence P. Park, Brandon A. Kohrt

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: attitudes; depression; developing countries; medical education; mental health; psychosis; service users; stigma

Online: 30 December 2020 (14:12:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0625.v1

Crosstalk between Existential Phenomenological Psychotherapy and Neuroscience in Mood and Anxiety Disorders

Lehel Balogh, Masaru Tanaka, Nóra Török, László Vécsei, Shigeru Taguchi

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depression; anxiety disorders; existential psychotherapy; phenomenological psychotherapy; daseinsanalysis; logotherapy; meaning-centered psychotherapy; functional magnetic resonance imaging; biomarker; kynurenines; Martin Heidegger; Medard Boss; Ludwig Binswanger; Viktor Frankl

Online: 24 December 2020 (13:39:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202012.0499.v1

A Rapid Assessment of Disaster Preparedness Needs and Resources during the COVID-19 Pandemic

Lawrence Palinkas, Benjamin Springgate, Olivia Sugarman, Jill Hancock, Ashley Wennerstrom, Catherine Haywood, Diana Meyers, Arthur Johnson, Mara Polk, Carter Pesson, Jessica Seay, Caroline Stallard, Kenneth Wells

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; disaster preparedness; disaster response; natural disasters; community-based organizations

Online: 21 December 2020 (10:43:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0724.v2

Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety—Particularities in the Context of COVID-19

Ana Miruna Dragoi, Ioana Radulescu, Anca Lucia Pop, Bogdana Adriana Năsui, Valentin Varlas, Simona Trifu

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: clozapine; schizophrenia; early-onset; pregnancy; bipolar affective disorder; agranulocytosis; COVID-19; pharmacogenetic

Online: 9 November 2020 (11:48:29 CET)

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Background: Clozapine (CLZ) use is precarious due to its neurological, cardiovascular, and hematological side effects; however, it is the gold standard in therapy-resistant schizophrenia (TRS) in adults and is underused. Objective: to examine the most recent CLZ data on (a) side effects concerning (b) recent pharmacological mechanisms, (c) therapy benefits, and (d) the particularities of the COVID-19 pandemic. Data sources: a search was performed in two databases (PubMed and Web of Science) using the specific keywords "clozapine" and "schizophrenia," "side effects," "agranulocytosis," "TRS," or "bipolar affective disorder (BAF)" for the last ten years. Study eligibility criteria: clinical trials on adults with acute symptoms of schizophrenia or related disorders. Results: We selected 37 studies, randomized controlled trials (RCTs), and clinical case series (CCS), centered on six main topics in the search area: (a) CLZ in schizophrenia, (b) CLZ in bipolar disorder, (c) side effects during the clozapine therapy, (d) CLZ in pregnancy, (e) CLZ in early-onset schizophrenia, and (f) CLZ therapy and COVID-19 infection. Limitations: We considered RCTs and CCS from two databases, limited to the search topics. Conclusions and implications of key findings: (a) Clozapine doses should be personalized for each patient based on pharmacogenetics testing when available; the genetic vulnerability postulates predictors of adverse reactions' severity; patients with a lower genetic risk could have less frequent hematological monitoring; (b) CLZ-associated risk of pulmonary embolism imposes prophylactic measures for venous thromboembolism; (c) convulsive episodes are not an indication for stopping treatment; the plasma concentration of clozapine is a better side effect predictor than the dosage; (d) COVID-19 infection may enhance clozapine toxicity, generating an increased risk of pneumonia. Therapy must be continued with proper monitoring of the white blood count, and the clozapine dose decreased by half until three days after the fever breaks; psychiatrists and healthcare providers must act together. Background: Clozapine (CLZ) use is precarious due to its neurological, cardiovascular, and hematological side effects; however, it is the gold standard in therapy-resistant schizophrenia (TRS) in adults and is underused. Objective: to examine the most recent CLZ data on (a) side effects concerning (b) recent pharmacological mechanisms, (c) therapy benefits, and (d) the particularities of the COVID-19 pandemic. Data sources: a search was performed in two databases (PubMed and Web of Science) using the specific keywords "clozapine" and "schizophrenia," "side effects," "agranulocytosis," "TRS," or "bipolar affective disorder (BAF)" for the last ten years. Study eligibility criteria: clinical trials on adults with acute symptoms of schizophrenia or related disorders. Results: We selected 37 studies, randomized controlled trials (RCTs), and clinical case series (CCS), centered on six main topics in the search area: (a) CLZ in schizophrenia, (b) CLZ in bipolar disorder, (c) side effects during the clozapine therapy, (d) CLZ in pregnancy, (e) CLZ in early-onset schizophrenia, and (f) CLZ therapy and COVID-19 infection. Limitations: We considered RCTs and CCS from two databases, limited to the search topics. Conclusions and implications of key findings: (a) Clozapine doses should be personalized for each patient based on pharmacogenetics testing when available; the genetic vulnerability postulates predictors of adverse reactions' severity; patients with a lower genetic risk could have less frequent hematological monitoring; (b) CLZ-associated risk of pulmonary embolism imposes prophylactic measures for venous thromboembolism; (c) convulsive episodes are not an indication for stopping treatment; the plasma concentration of clozapine is a better side effect predictor than the dosage; (d) COVID-19 infection may enhance clozapine toxicity, generating an increased risk of pneumonia. Therapy must be continued with proper monitoring of the white blood count, and the clozapine dose decreased by half until three days after the fever breaks; psychiatrists and healthcare providers must act together.

Preprint ARTICLE | doi:10.20944/preprints202010.0375.v1

Feasibility of the Schizophrenia Hope Scale-9: A psychometric study

Kwisoon Choe, Eunjung Ryu, Sunghee Kim

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: hope; mental health; reliability; validity; principal component analysis; schizophrenia

Online: 19 October 2020 (11:18:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0619.v1

Prevalence of Stress in Healthcare Professional During COVID-19 Pandemic in Northeast México: A Remote Fast Survey Evaluation, the Use of an Adapted COVID-19 Stress Scale

Juan Luis Delgado-Gallegos, Rene de Jesus Montemayor-Garza, Gerardo R. Padilla-Rivas, Hector Franco-Villareal, Jose Francisco Islas

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19 Mexico; stress in healthcare professionals; COVID-19 stress scale

Online: 26 September 2020 (08:07:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0417.v1

Neglect of Legal Statute Influence on Health Outcomes in Studies about Human Cannabis Use

Thiago Moulin, José Airton Alves, João Menezes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: schizophrenia; stress; drug policy; environment; contaminants; pesticides; fungi; prohibition

Online: 18 September 2020 (04:21:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0347.v1

Increased Autoimmune Responses to Oxidative Specific Epitopes in Bipolar Disorder Type 1 and Major Depression: Towards A Data-Driven, Mechanistic Model of Mood Disorders

Drozdstoy Stoyanov, Jean–Claude Leunis, Marianna Murdjeva, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: mood disorders; depression; nitrosative and oxidative stress; IgM autoimmunity; neuro-immune; inflammation

Online: 16 September 2020 (04:17:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0159.v1

The Impact of Sex on Changes in Plasma Corticosterone and Cotinine Levels Induced by Nicotine in C57BL/6J Mice

Khoa Nguyen, Keiko Kanamori, Abdul Hamid, Kabirullah Lutfy

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Nicotine; Cotinine; Corticosterone; LCMS; Sex; C57BL/6J mouse; CYP2A5; Plasma Levels; Subcutaneous Injection

Online: 7 September 2020 (08:08:54 CEST)

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Working Paper ARTICLE

Short Form 36-Item Health Survey (SF-36) in Patients with Physical Disabilities: Validity and Reliability

Nassim Ahmadi, Mojgan Rajati, Maryam Khazaei Pool, Leili Salehi, Mohammad Ebrahimi, Fatemeh Rajati

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Disabled Persons; Health Status; Iran; Psychometrics; Quality of Life; Reliability

Online: 7 September 2020 (03:24:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0149.v1

The Relationships between Smartphone Addiction of Middle School Students and Smartphone Usage Types, Depression, ADHD, Stress, Interpersonal Problems, and Parenting Attitude

Youl Pyo Hong, Yeon Ok Yeom, Myung Ho Lim

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Smartphone Addiction; Middle School Students; Smartphone Usage Types; Depression; Parenting Attitude

Online: 6 September 2020 (16:27:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0053.v1

A Nomothetic Network Model Disclosing the Comorbidity of Depression and Unstable Angina: Effects of Atherogenicity, Insulin Resistance, Immune Activation, Antioxidants, the Endogenous Opioid System, Trace Elements, and Macrominerals

Rana Mousa, Hasan Smesam, Hasan Qazmooz, Hussein Al-Hakeim, Michael Maes

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: unstable angina, inflammation, neuro-immune, major depression, oxidative stress, antioxidants, atherogenicity

Online: 3 September 2020 (04:40:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0709.v1

COVID-19 Suicide among Adolescents and Youths during the Lockdown: An Exploratory Study based on Media Reports

Md. Dilshad Manzar, Abdulrhman Albougami, Norina Usman, Mohammed A. Mamun

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19; lockdown; psychological impacts; self-harm; suicide; COVID-19 suicide; teenage suicide; adolescent suicide; youth suicide; press reporting suicide

Online: 31 August 2020 (05:43:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0606.v1

Stigma and Life Satisfaction among Out-of-School Korean Youths: The Mediating Roles of Self-Esteem and Depression

Myong Sun Cho

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: life satisfaction; depression; self-esteem; stigma; out of school youth; structural equation modeling

Online: 27 August 2020 (09:02:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0431.v1

Lipid Profile, Lipoprotein Subfractions, and Fluidity of Membranes in Children and Adolescents with Depressive Disorder: Effect of Omega-3 Fatty Acids in A Double-blind Randomized Controlled Study

Barbora Katrenčíková, Magdaléna Vaváková, Iveta Waczulíková, Stanislav Oravec, Iveta Garaiova, Zuzana Nagyová, Nataša Hlaváčová, Zdenka Ďuračková, Jana Trebatická

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: depressive disorder; omega-3 fatty acids; lipid profile; fluidity of membrane; children and adolescents

Online: 20 August 2020 (05:48:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0421.v1

How to Construct a Bottom-up Nomothetic Network Model and Disclose Novel Nosological Classes by Integrating Risk Resilience and Adverse Outcome Pathways with the Phenome of Schizophrenia

Michael Maes, Aristo Vodjani, Piotr Galecki, Buranee Kanchanatawan

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: deficit schizophrenia; cytokines; inflammation; neuro-immune; oxidative stress; leaky gut

Online: 20 August 2020 (03:24:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0342.v1

‘I Can’t Breathe’: Anxiety and Emotion Awareness in Older Adolescents at The Time of Covid-19

Pietro Smirni, Gioacchino Lavanco, Daniela Smirni

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: COVID-19 pandemic; virus’ transmission; fear of contagion; breathing difficulty; healthy adolescents; emotion awareness; anxiety-state

Online: 15 August 2020 (08:25:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0207.v1

The Prevalence and Sociodemographic Correlates of Social phobia in Oman: Online National Survey

Aamal Ambusaidi, Salim Al Huseini, Hiba Alshaqsi, Manal AlGhafri, Moon-Fai Chan, Nasser Al-Sibani, Samir Al-Adawi

Subject: Medicine & Pharmacology, Psychiatry & Mental Health Studies Keywords: Social Anxiety Disorder; Social Phobia, Online Survey; Adult, Oman; Liebowitz Social Anxiety Scale

Online: 8 August 2020 (09:39:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0070.v1