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Preprint ARTICLE | doi:10.20944/preprints201703.0227.v1

New Link between Skin Microbiota Diversity and Skin Health: Proposal to Use This as a Mechanism to Determine Whether Cosmetic Products Damage the Skin and Are a Cause of the Skin Allergy Epidemic

Christopher Wallen-Russell, Sam Wallen-Russell

Subject: Medicine And Pharmacology, Dermatology Keywords: biodiversity; skin allergy; benchmark skin health values; effect of synthetic cosmetics on skin; 21st century skin ailments; measure skin health; healthy skin ecosystem; healthy skin bacteria; damaged skin bacteria; perfect skin

Online: 31 March 2017 (08:52:14 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201608.0228.v1

Sweat Gland Biopsy: A Possible Early Diagnostic Tool in the Anderson-Fabry Disease

Giuseppe Pistone, Valentina Caputo, Davide Fattore, Giovanna Tilotta, Maria Rita Bongiorno

Subject: Medicine And Pharmacology, Dermatology Keywords: lysosomal diseases; diagnosis

Online: 30 August 2016 (04:27:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201904.0327.v1

An Extensive Review of Sunscreen and Suntan Preparations

AK Mohiuddin

Subject: Medicine And Pharmacology, Dermatology Keywords: sunscreen; sunburn; UV Radiation; melanoma; photoaging

Online: 30 April 2019 (11:18:23 CEST)

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The sunscreen industry is achieving remarkable worldwide prominence by responding to the growing need for skin protection with fast-paced innovation. Increased consumer awareness of the harmful effects of sunlight has fueled the demand for improved photo protection. The need for broad-spectrum protection from both UVA and UVB rays has inspired scientists worldwide to research new cosmetic formulations and delivery systems. More effective sunscreen actives, emollients and novel cosmetic and functional ingredients have been regularly added to the formulator’s repertoire. Creativity in innovation has been hindered only by regulatory agencies and patent restrictions worldwide. Familiarity with the current restrictive regulations and patent law infringements has become integral to any research effort attempting to provide improved protection to individuals affected by the sun’s damaging effects. The increasing incidence of skin cancers and photo damaging effects caused by ultraviolet radiation has increased the use of sun screening agents, which have shown beneficial effects in reducing the symptoms and reoccurrence of these problems. Unlike the situation in Europe where sunscreen ingredients are considered under cosmetics guidelines, the FDA is required to define sunscreens as drugs since they are advertised to prevent sunburn and, more recently, the risk of skin cancer. In the USA, the FDA has been regulating this industry since August 25, 1978, with the publication of the Advance Notice of Proposed Rulemaking. Sunscreens are considered drugs and cosmetics and therefore must be governed by the FDA-OTC monograph. With the variety of sunscreen agents used in cosmetic and UV protection products, Australia, Canada, and the European Union (EU) have also developed regulatory protocols on safe sunscreen product use. Unlike the USA though, Australia has approved 34 active sunscreen ingredients and the EU has approved 28 of these ingredients. Current FDA regulations allow labeling of sunscreen products to a maximum of 30þ, despite the many products currently available with numbers as high as 100. From a cosmetic formulation point of view, increasing the SPF number in a product is governed by simple chemical principles.

Preprint ARTICLE | doi:10.20944/preprints202005.0500.v1

Respect of Skin Microbiome with Different Types of LeavE-on Skincare Products, an Ecobiological Approach

Sylvie Callejon, Félix Giraud, Florence Larue, Armonie Buisson, Léa Matéos, Laurence Grare, Aurélie Guyoux, Eric Perrier, Nathalie Ardiet, Sandra Trompezinski

Subject: Medicine And Pharmacology, Dermatology Keywords: skin microbiome; skincare; cosmetic products; ecobiology; microbiome friendly

Online: 31 May 2020 (20:12:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0020.v1

Graviola (Annona muricata) Exerts Anti-Proliferative, Anti-Clonogenic and Pro-Apoptotic Effects in Human Non-Melanoma Skin Cancer UW-BCC1 and A431 Cells In Vitro: Involvement of Hedgehog Signaling

Jean Christopher Chamcheu, Islam Rady, Roxane-Cherille N. Chamcheu, Abu Bakar Siddique, Melissa B. Bloch, Sergette Banang Mbeumi, Abiola S. Babatunde, Mohammad B. Uddin, Felicite K. Noubissi, Peter W. Jurutka, Yong-Yu Liu, Vladimir S. Spiegelman, G. Kerr Whitfield, Khalid A. El Sayed

Subject: Medicine And Pharmacology, Dermatology Keywords: Annona muricata; apoptosis; basal cell carcinoma; cutaneous squamous cell carcinoma; graviola; Hedgehog signaling pathway; natural products chemistry; non-melanoma skin cancer

Online: 1 June 2018 (13:00:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0425.v1

Periorbital Hyperpigmentation, a Dermatologic Condition Having a Strong Geographic and Ethnic Determinism

Felicia Andrei, Daciana Grujic, Cristina Lazar, Anca Dragomirescu

Subject: Medicine And Pharmacology, Dermatology Keywords: hyperpigmentation; palpebral region; geographic skin differences; ethnic predisposition; skin disorder;

Online: 23 July 2018 (12:56:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0121.v1

Antibacterial Activity of Ethanolic Extract of Cinnamon Bark and Honey and Their Combination Effects Against Acne Causing Bacteria

Elin Julianti, Kasturi K. Rajah, Irda Fidrianny

Subject: Medicine And Pharmacology, Dermatology Keywords: antibacterial activity, cinnamon, honey, checkerboards method, synergistic activity

Online: 23 December 2016 (18:37:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202103.0061.v1

Oral and Topical Vitamin D, Sunshine, and UVB Phototherapy Safely Control Psoriasis in Patients with Normal Pretreatment Serum 25-hydroxyvitamin D Concentrations: A Literature Review and Discussion of Health Implications

Patrick J McCullough, William McCullough, Douglas Lehrer MD, Jeffrey Travers MD, Steven Repas

Subject: Medicine And Pharmacology, Dermatology Keywords: vitamin D3, D2, calcitriol, oral, topical, serum 25-hydroxyvitamin D, psoriasis, skin diseases, UVB, phototherapy, sunshine, COVID-19, regulatory T lymphocytes

Online: 2 March 2021 (09:44:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0091.v1

Fisetin a 3, 7, 3′, 4′-Tetrahydroxyflavone Inhibits PI3K/Akt/mTOR and MAPK Pathways and Ameliorates Psoriasis Pathology in 2D and 3D Organotypic Human Inflammatory Skin Models

Jean Christopher Chamcheu, Stephane Esnault, Vaqar M. Adhami, Andrea L. Noll, Sergette Banang-Mbeumi, Tithi Roy, Sitanshu S. Singh, Shile Huang, Konstantin Gus Kousoulas, Hasan Mukhtar

Subject: Medicine And Pharmacology, Dermatology Keywords: fisetin; psoriasis; normal human epidermal keratinocyte; cell signaling; cell differentiation; proliferation; inflammatory cytokine; PBMC; CD4+ T lymphocyte; 3D psoriasis-like skin disease model

Online: 9 September 2019 (07:48:26 CEST)

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Psoriasis is a chronic immune-mediated skin disease that involves interaction of both immune and skin cells, and is characterized by cytokine-driven epidermal hyperplasia, deviant differentiation, inflammation and angiogenesis. Because available treatments for psoriasis have significant limitations, dietary products are potential natural sources of therapeutic molecules, which can rescind molecular defects associated with psoriasis and could be developed for its management. Fisetin (3,7,3′,4′- tetrahydroxyflavone), a phytochemical naturally found in pigmented fruits and vegetables has demonstrated pro-apoptotic and antioxidant effects in several malignancies. This study utilized biochemical, cellular, pharmacological and tissue-engineering tools to characterize the effects of fisetin on normal human epidermal keratinocytes (NHEKs), peripheral blood mononuclear cells (PBMC) and CD4+ T lymphocytes in 2D and 3D psoriasis-like disease models. Fisetin treatment of NHEKs dose and time-dependently induced differentiation and inhibited interleukin-22-induced proliferation, as well as activation of the PI3K/Akt/mTOR pathway. Fisetin treatment of TNF-α-stimulated NHEKs significantly inhibited the activation of p38 and JNK, but had no effect on ERK1/2. In addition, fisetin treatment significantly decreased the secretion of Th1/Th-17 pro-inflammatory cytokines, particularly IFNγ and IL-17A by 12-O- tetradecanolylphorbol 13-acetate (TPA)-stimulated NHEKs and anti-CD3/CD28-activated human PBMCs. Furthermore, we established the in-vivo relevance of fisetin functions, using a 3D full-thickness human skin model of psoriasis (FTRHSP) that closely mimics in-vivo human psoriatic skin-lesions. Herein, fisetin significantly ameliorated psoriasis-like disease features, and decreased the production of IL-17 by CD4+ T lymphocytes co-cultured with FTRHSP. Collectively, our data identify pro-differentiative, anti-proliferative and anti-inflammatory effects of fisetin, via modulation of PI3K-Akt-mTOR and p38/JNK pathways and the production of cytokines in 2D and 3D human skin model of psoriasis. These results suggest that fisetin has a great potential to be developed as an effective and inexpensive agent for the treatment of psoriasis and other related inflammatory skin disorders.

Preprint ARTICLE | doi:10.20944/preprints201710.0136.v1

HtrA1 Is Specifically Up-Regulated in Active Keloid Lesions and Stimulates Keloids Development

Satoko Yamawaki, Motoko Naitoh, Hiroshi Kubota, Rino Aya, Yasuhiro Katayama, Toshihiro Ishiko, Taku Tamura, Katsuhiro Yoshikawa, Tatsuki Enoshiri, Mika Ikeda, Shigehiko Suzuki

Subject: Medicine And Pharmacology, Dermatology Keywords: keloids; fibroproliferative disorder; HtrA1; inflammation

Online: 20 October 2017 (06:22:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0001.v2

The Identification, Management, and Control of Scabies in Australian Aboriginal and Torres Strait Islander Communities

Timothy Mettam

Subject: Medicine And Pharmacology, Dermatology Keywords: Aboriginal; Australia; control; diagnosis; identification; prevention; scabies; sarcoptes scabiei; Torres Strait Islander; treatment

Online: 8 January 2018 (16:00:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0260.v1

Anti-Wrinkle Mechanism of Melatonin in UVB Treated HaCaT Keratinocytes and Hairless Mouse via Inhibition of ROS and Sonic Hedgehog Mediated Inflammatory Proteins

Eun Kyung Park, Hyo-Jung Lee, Hyemin Lee, Ju-Ha Kim, Jisung Hwang, Sung-Hoon Kim

Subject: Medicine And Pharmacology, Dermatology Keywords: melatonin; UVB; HaCaT keratinocytes; collagen; ROS; Hedgehog; Cox-2; MMP-1

Online: 18 May 2018 (08:51:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0018.v1

Identification of Hub Genes and Key Pathways Associated with Atopic Dermatitis via Integrated Bioinformatics

Yue Sun, Angela Weihong Yang, George Binh Lenon

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic dermatitis; AD; dermatology; target identification; pathway identification; bioinformatics; protein-protein networks

Online: 1 July 2019 (12:47:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202111.0086.v1

Botulinum Neurotoxin Type A in the Treatment of Oily Skin and Acne: Evidence and a Proposed Mechanism

Nark-Kyoung Rho, Young-Chun Gil

Subject: Medicine And Pharmacology, Dermatology Keywords: acetylcholine; acne vulgaris; botulinum toxins; cholinergic receptors; non-neuronal cholinergic system; oily skin; sebaceous glands; sebum

Online: 3 November 2021 (14:26:33 CET)

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Working Paper ARTICLE

Could Strengthening the Gut and Skin Microbiome Help with the Adverse Effects after Stopping Long Term Topical Steroid Use?

Christopher Wallen-Russell, Anja Gijsberts-Veens, Samuel Wallen-Russell

Subject: Medicine And Pharmacology, Dermatology Keywords: topical steroid withdrawal; topical steroids; eczema; atopic dermatitis; skin microbiome; gut mi-crobiome; microbiome; biodiversity; skin allergy epidemic;

Online: 8 September 2021 (20:19:35 CEST)

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We set up this preliminary study to evaluate one main question: could strengthening the microbiome have potential benefits for patients suffering with adverse effects after stopping long term topical steroid use? We aim to turn it into a much larger study if the results show promise. After commonly being prescribed for eczema, cessation of topical steroid use, especially after long periods of inappropriate use, can leave lasting adverse effects on the body and skin, known by some as topical steroid withdrawal (TSW). Furthermore, the subsequent withdrawal the body experiences when coming off the drug can leave lasting adverse effects on the body and skin, known by some as topical steroid withdrawal (TSW). This preliminary study involved seven human participants suffering with skin problems associated with TSW who approached Dr. Anja Gijsberts-Veens of their own volition because they were interested in more natural recovery methods. Five completed the study in full. Progress in skin condition was tracked by self-assessed symptom severity questionnaires filled out at the beginning and end of the study. The skin microbiome was addressed by using a 100% natural product shown in previous work to significantly increase skin microbiome biodiversity. Three participants implemented dietary changes and supplementation in response to guidance after fecal sample analysis to improve their gut health and biodiversity. The average improvement in skin symptoms for all participants was 40% and average symptom improvement ranged from 14% for Patient 5 to 92% for Patient 1. On average, the participants saw an improvement in 85% of their symptoms and a stagnation or regression in 11% and 4% respectively. We believe these results show enough promise to warrant expansion of this research to use a larger sample size, preferably 50+ participants, in future work. We also aim to swab the skin of participants to assess the effect on the skin microbiome from skin and gut treatments, as well as including more in-depth analysis of skin and gut microbiomes.

Preprint REVIEW | doi:10.20944/preprints201805.0158.v1

Cutaneous and Mucosal Manifestations Associated to Celiac Disease

Luis Rodrigo, Valia-Patricia Beteta, Nuria Álvarez, Celia Gómez de Castro, Álvaro de Dios, Laura Palacios, Jorge Santos-Juanes

Subject: Medicine And Pharmacology, Dermatology Keywords: celiac disease; dermatitis herpetiformis; alopecia areata; cutaneous vasculitis; urticaria; atopic dermatitis; psoriasis; recurrent aphtous ulceration; chronic ulcerative stomatitis; gluten-free diet

Online: 10 May 2018 (08:04:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0166.v1

The Effect of a Color Tattoo on the Local Skin Redox Regulatory Network: An N-of-1 Study

Jan Homolak

Subject: Medicine And Pharmacology, Dermatology Keywords: Tattoo; Tattoo ink; Oxidative stress; Phthalocyanine; Skin

Online: 14 June 2020 (04:13:53 CEST)

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Introduction: Tattooing has been extensively discussed in the literature in the context of hygiene and infectious diseases. On the other hand, pathophysiological effects of tattoo inks in the human body are yet to be elucidated. Oxidative stress is considered to be the most important mediator of potential adverse effects of tattooing, however at the moment there is no experimental evidence for tattoo ink-related oxidative stress in the human body. The aim of this study was to examine the effect of a blue tattoo on skin redox regulatory network (RRN) parameters in a single human subject. Materials and Methods: A blue tattoo on my left forearm was used in the research. Tattooed skin surface oxidation-reduction potential (ORP) experiment was done by a PH60F flat probe. Capillary blood from the tattoo and the control area was extracted and analyzed with I₂/KI-stabilized microORP, nitrocellulose redox permanganometry (NRP), carbonato-cobaltate (III) formation-derived H₂O₂ dissociation rate assay, 1,2,3-Trihydroxybenzene autoxidation assay, thiobarbituric reactive substances (TBARS) assay and 5,5,’-dithio-bis-(2-nitrobenzoic acid) (DTNB)-based determination of free thiol content in low molecular weight and protein precipitate fraction. Results: Surface ORP analysis revealed a greater antioxidant capacity of tattooed skin in comparison with the control (CTR). Capillary blood analysis confirmed slightly greater reductive capacity in the tattoo sample both by microORP (-4.33mV vs CTR) and NRP (+1.1%). Hydrogen peroxide dissociation rate (+11.8%), superoxide dismutase activity (+0.7%), and protein sulfhydryl content (+8.5%) were all increased, and lipid peroxidation (-15%) and low molecular weight thiols (-2.8%) were reduced in a tattoo sample in comparison with the CTR. Conclusion: In this N-of-1 study RRN of tattooed skin was shifted towards a more reductive state with most of the parameters indicating reduced levels of oxidative stress in comparison with nontattooed skin. Local antioxidant effect of copper(II) phthalocyanine provides one possible explanation of the observed effects.

Preprint ARTICLE | doi:10.20944/preprints201809.0490.v1

Anti-Aging Efficacy of Melatonin-Based Cream: Clinical and Instrumental Skin Evaluation

Massimo Milani, Mario Puviani

Subject: Medicine And Pharmacology, Dermatology Keywords: melatonin, skin aging, ANTERA 3D.

Online: 25 September 2018 (15:43:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0001.v1

The Identification, Management, and Control of Scabies in Australian Aboriginal and Torres Strait Islander Communities

Timothy Mettam

Subject: Medicine And Pharmacology, Dermatology Keywords: Aboriginal; Australia; control; diagnosis; identification; prevention; scabies; sarcoptes scabiei; Torres Strait Islander; treatment

Online: 2 January 2018 (04:42:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202207.0449.v1

Dysregulated Expression of Ion Channels in Sensory Neurons Enhances Action Potential Afterhyperpolarization in Patients with Chronic Kidney Disease–Associated Pruritus

Akishi Momose, Michihiro Yabe, Shigetoshi Chiba, Kenjirou Kumakawa, Yasuo Shiraiwa, Hiroki Mizukami

Subject: Medicine And Pharmacology, Dermatology Keywords: CKD-aP; ion channels; action potential; hyperpolarization; RT-PCR

Online: 29 July 2022 (04:50:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints201812.0140.v1

Association of the CYP17 (T-34C) Polymorphism and the Risk of Acne Vulgaris: A Meta-Analysis

Mazaher Ramezani, Elisa Zavattaro, Masoud Sadeghi

Subject: Medicine And Pharmacology, Dermatology Keywords: acne; polymorphism; genetics; CYP17; ethnicity

Online: 12 December 2018 (05:30:43 CET)

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Preprint REVIEW | doi:10.20944/preprints201809.0215.v1

Elucidating Role of Bacteria in Psoriatic Disease: From Skin and Gut Perspectives

Bakytgul Yermekbayeva, Togzhan Algazina, Madina Razbekova, Albert Pinhasov, Gulnar Batpenova, Almagul Kushugulova

Subject: Medicine And Pharmacology, Dermatology Keywords: gut microbiota; skin microbiota; inflammation; psoriasis; psoriatic arthritis; dysbiosis

Online: 12 September 2018 (07:49:33 CEST)

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Working Paper ARTICLE

KIT Mutation Incidence and Pattern of Skin Melanoma in a Central European Country

Viktoria Doma, Tamas Barbai, Marius Beleaua, Ilona Kovalszky, Erzsebet Raso, Jozsef Timar

Subject: Medicine And Pharmacology, Dermatology Keywords: skin melanoma, KIT mutation, Sanger sequencing

Online: 6 August 2019 (12:33:31 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202308.0827.v1

Assessment of NADH/NAD+ Redox Imbalance in Psoriatic Lesions Using the FMSF Technique: Therapeutic Aspects

Jerzy Gebicki, Tomasz Filipiak, Andrzej Marcinek, Anna Woźniacka

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; NADH/NAD+ redox imbalance; NADH fluorescence; FMSF technique

Online: 10 August 2023 (07:12:46 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201912.0170.v1

Necrotic Skin Infection by Sphingomonas Paucimobilis in Amazonia Region

Talles Henrique Pichinelli Maffei, Frederico Alberto Bussolaro, Arlei Belaus, Alexandra Prevedello, Claudine Thereza-Bussolaro

Subject: Medicine And Pharmacology, Dermatology Keywords: sphingomonas; gram-negative bacterial infection; skin disease; bacterial

Online: 12 December 2019 (10:01:35 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0772.v1

Beneficial Effects of Marine Algae-Derived Carbohydrates for Skin Health

Ji Hye Kim, Jae-Eun Lee, Kyoung Heon Kim, Nam Joo Kang

Subject: Medicine And Pharmacology, Dermatology Keywords: Marine algae; Carbohydrates; Oligosaccharides; Monosaccharides; Skin health; Cosmeceuticals

Online: 1 November 2018 (18:19:37 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0615.v1

Onchodermatitis: Where Are We Now?

Michele E. Murdoch

Subject: Medicine And Pharmacology, Dermatology Keywords: onchodermatitis; onchocercal skin disease; onchocerciasis; ivermectin

Online: 31 July 2018 (09:47:34 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201812.0257.v1

New Cosmetic Formulation for Treatment of Mild to Moderate Infantile Atopic Dermatitis

Raul de Lucas, Cristina García Millán, Azahara Pérez-Davó, Esther Moreno, Pedro Redondo

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic; dermatitis; emollient; moisturizer; epidermal barrier; filaggrin

Online: 21 December 2018 (07:37:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0131.v1

Anti-allergic Effects Of Fertilized Red Ginseng Marc On 2,4-dinitrochlorobenzene-induced Atopic Dermatitis-like Mice Model

Yeun Soo Jung, Jae Young Choi, Young-Sam Kwon, Gyu-Ryeul Park, VinayKumar Dachuri, Young Woo Kim, Sae-Kwang Ku, Chang-Hyun Song

Subject: Medicine And Pharmacology, Dermatology Keywords: AD; allergy; skin; DNCB; Panax ginseng; red ginseng marc; fermentation

Online: 9 February 2022 (10:26:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0043.v1

Managing Skin Ageing as a Modifiable Disorder – The Clinical Application of Nourella® Dual Approach Comprising a Nano-encapsulated Retinoid, Retilex-A® and a Skin Proteoglycan Replacement Therapy, Vercilex®

Jan Wadstein, Israel Sánchez Alvarez, Erling Thom, Lidia Bernal López

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin Aging; Rejuvenation; Skin Cream; Retinoid formulation; RetileX-A; Vercilex

Online: 2 November 2021 (10:55:27 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0128.v1

Rapid Response of Refractory Systemic Lupus Erythematosus Skin Manifestations to Anifrolumab – A Case-Based Review of Clinical Trial Data Suggesting A Domain-Based Therapeutic Approach

Marlene Plüß, Silvia Piantoni, Chris Wincup, Peter Korsten

Subject: Medicine And Pharmacology, Dermatology Keywords: systemic lupus erythematosus; anifrolumab; interferon; cutaneous lupus erythematosus

Online: 10 May 2022 (07:45:29 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202004.0150.v1

Cytoplasmic Increase of Hsp70 Protein: Potential New Biomarker of Early Infiltration of Cutaneous Squamous Cell Carcinoma Arising from Actinic Keratosis

Montserrat Fernandez-Guarino, José Javier Zamorano León, Antonio José López Farré, Maria Luisa Gonzalez Morales, Ana Isabel Sanchez Adrada, Jose Barrio Garde, Jose Antonio Arias Navalon, Pedro Jaen-Olasolo

Subject: Medicine And Pharmacology, Dermatology Keywords: actinic keratosis; cutaneous squamous cell carcinoma; cytoplams; skin cancer; heat shock protein

Online: 9 April 2020 (12:21:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0166.v3

Discrimination of Acne Vulgaris with Human Scalp Hair Tissues Using FTIR-ATR Spectroscopy

Padmavathi Ramanujam, Rajamannan B, Guasekaran S, Ramkumar GR, Sankari G, Muthu S

Subject: Medicine And Pharmacology, Dermatology Keywords: Acne Vulgaris; Hair tissue samples; Discrimination; FTIR-ATR

Online: 4 August 2020 (08:21:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0171.v1

Ulmus Parvifolia Accelerate Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

Min Cheol Kang, Silvia Yumnam, Woo Sung Park, Hae Min So, Ki Hyun Kim, Meong Cheol Shin, Mi-Jeong Ahn, Sun Yeou Kim

Subject: Medicine And Pharmacology, Dermatology Keywords: ulmus parvifolia; wound healing; matrix metalloproteinase; transforming growth factor; skin rejuvernation

Online: 15 November 2019 (04:05:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0667.v1

Visfatin Promotes Wound Healing Through the Activation of ERK1/2 and JNK1/2 Pathway

Byungcheol Lee, Jisun Song, Arim Lee, Daeho Cho, Tae Sung Kim

Subject: Medicine And Pharmacology, Dermatology Keywords: visfatin; wound healing; VEGF; MAPK

Online: 29 October 2018 (09:54:28 CET)

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Preprint REVIEW | doi:10.20944/preprints202205.0056.v1

Tetracyclines - An Important Therapeutic Tool for Dermatologist

Małgorzata Orylska-Ratyńska, Waldemar Placek, Agnieszka Owczarczyk-Saczonek

Subject: Medicine And Pharmacology, Dermatology Keywords: tetracyclines; doxycycline; limecycline; minocycline; pleiotrophy; non-antibiotic properties

Online: 6 May 2022 (03:34:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0367.v1

Rosmarinic Acid Multifunctional Sunscreen: Comet Assay and in Vivo Establishment of Cutaneous Attributes

Thalita Marcílio Cândido, Maíra Bueno Ariede, Claudinéia Aparecida Sales de Oliveira Pinto, Wagner Vidal Magalhães, Natália Mencacci Esteves Pedro, Giovana Padovani, Bianca da Silva Sufi, Maria Valéria Robles Velasco, Catarina Rosado, André Rolim Baby

Subject: Medicine And Pharmacology, Dermatology Keywords: rosmarinic acid; anti-inflammatory activity; comet assay; sunscreen; skin biocompatibility

Online: 27 June 2022 (13:22:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0239.v1

Prognostic Value of the Intratumoral Lymphocyte to Monocyte Ratio and M0 Macrophage Enrichment in the Melanoma Immune Microenvironment

Neil Jairath, Mark Farha, Ruple Jairath, Paul Harms, Lam Tsoi, Trilokraj Tejasvi

Subject: Medicine And Pharmacology, Dermatology Keywords: Cutaneous Melanoma; Immunotherapy; Lymphocytes; Monocytes; Macrophages; RNAseq; tumor immune microenvironment

Online: 11 September 2020 (04:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0356.v1

Teledermoscopy in the Diagnosis of Melanocytic and Non-melanocytic Skin Lesions: Nurugo^tm Derma Smartphone Microscope as a Possible New Tool in Daily Clinical Practice

Federica Veronese, Vanessa Tarantino, Elisa Zavattaro, Francesca Biacchi, Chiara Airoldi, Massimo Salvi, Silvia Seoni, Francesco Branciforti, Kristen M. Meiburger, Paola Savoia

Subject: Medicine And Pharmacology, Dermatology Keywords: Teledermatology; Teledermoscopy; skin cancer diagnosis

Online: 26 May 2022 (07:53:54 CEST)

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Background Due to the COVID-19 pandemic, teledermoscopy has been increasingly used in the remote diagnosis of skin cancers. In a study conducted in 2020, we demonstrated a potential role of an inexpensive device (NurugoTM Derma) as a first triage to select the skin lesions that require a face-to-face consultation with dermatologists. Herein, we report the results of a novel study that aims to better investigate the performance of NurugoTM. Objectives i) verify whether the NurugoTM can be a communication tool between the General Practitioner (GP) and dermatologist in the first assessment of skin lesions; ii) analyze the degree of diagnostic-therapeutic agreement between dermatologists; iii) estimate the number of potentially serious diagnostic errors. Methods One hundred forty-four images of skin lesions were collected at the Dermatology Outpatient Clinic in Novara using a conventional dermatoscope (instrument F), the NurugoTM (instrument N), and the latter with the interposition of a laboratory slide (instrument V). The images were evaluated in-blind by four dermatologists, and each was asked to make a diagnosis and to specify a possible treatment. Results: Our data show that F gave higher agreement values for all dermatologists, concerning the real clinical diagnosis. Nevertheless, a medium/moderate agreement value was obtained also for N and V instruments and that can be considered encouraging and indicate that all examined tools can potentially be used for the first screening of skin lesions. The total amount of misclassified lesions was limited (especially with the V tool), with up to nine malignant lesions wrongly classified as benign. Conclusions NurugoTM, with adequate training, can be used to build a specific support network between GP and dermatologist or between dermatologists. Furthermore, its use could be extended to the diagnosis and follow-up of other skin diseases, especially for frail patients in emergencies such as the current pandemic context.

Preprint REVIEW | doi:10.20944/preprints202205.0037.v1

Immunomodulation of Melanoma by Chemo-Thermo-Immuno-Therapy Using Conjugates of Melano-Genesis Substrate NPrCAP and Magnetite Nanoparticles

Yasuaki Tamura, Akira Ito, Kazumasa Wakamatsu, Takafumi Kamiya, Toshihiko Torigoe, Hiroyuki Honda, Toshiharu Yamashita, Hisashi Uhara, Shosuke Ito, Kowichi Jimbow

Subject: Medicine And Pharmacology, Dermatology Keywords: Melanoma; Chemo-thermo-immuno-therapy; Melanogenesis; Magnetite nanoparticle; Drug delivery system; Heat shock protein; In situ vaccine therapy; Immune checkpoint inhibitor

Online: 5 May 2022 (12:23:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202211.0133.v1

New Therapeutic Applications of Ozenoxacin in Superficial Skin Infections in Geriatric Patients: A Case Series

Jordi Esquirol Caussa, Josep Sánchez Aldeguer, Elisabeth Herrero Vila, Iñaki Antón Gorostidi, Miquel Colomer Giner, Anna Olivé Torralba, Josep Mª Abella Grau, Sònia Jiménez Herreros, Carlos Llobregat Delgado

Subject: Medicine And Pharmacology, Dermatology Keywords: skin infection; antibiotics; quinolone; S. aureus; geriatrics

Online: 8 November 2022 (01:57:03 CET)

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INTRODUCTION: Superficial cutaneous bacterial infections have a high incidence in geriatric patients. The most implicated pathogens are gram-positive cocci (Staphylococcus aureus, Streptococcus pyogenes) while gram-negative germs are also implicated. Resistances to common topical antibiotics (mupirocin, fusidic acid) require alternatives to gram-positive and gram-negative microorganisms.Ozenoxacin cream for topical use (non-fluorinated bactericidal quinolone), in other countries and with other galenics, is indicated in children older than 6 months and in adults as a treatment of superficial bacterial infections, such as acne. In Spain, ozenoxacin cream is indicated only for non-bullous impetigo; scientific evidence show effectiveness also in other superficial skin bacterial infections.A cases series of clinical use of ozenoxacin in bacterial superficial skin infections in geriatric patients (institutionalized or community dwelling) is presented.METHODS: Multicenter case series (March-August 2022) of bacterial superficial skin infections treated with ozenoxacin cream (10mg/g every 12h, 5days); data from medical records (controls: 1-3-5 days), after obtaining informed consent (use of data and images).RESULTS: Series of 28 patients (mean age: 84,79) from nine nursing homes and one outpatient geriatric service, including acute and subacute/chronic cases.In all cases treatment was ozenoxacin 10mg/g topical cream applied every 12 hours for 5 days according to medical prescription (except for one case in which 3 days were enough for complete healing and another case treated for 10 days).Results showed complete healing in all 20 acute cases and significant clinical improvement in all subacute/chronic cases (with complete healing in one of them). Professionals scored the effectiveness in acute cases as a mean 4.5 points (maximum score: 5, p<.0001) and in subacute/chronic cases as 3.8 points (p=.010).There was no skin irritation or other adverse effects in anyone of the patients, and clinical improvement of pain, itching and other symptoms was observed, suggesting an anti-inflammatory effect. DISCUSSION AND CONCLUSIONS: Our results seem to demonstrate the effectiveness and tolerability of ozenozacin cream in bacterial infections other than non-bullous impetigo. Ozenoxacin cream is indicated only for the treatment of non-bullous impetigo; however, it is also shown to be effective, both in the scientific evidence and in our case series, for other superficial bacterial skin infections, both acute and subacute/chronic, suggesting the opportunity for clinical studies with an experimental design to evaluate the findings of clinical practice and to be able to have a therapeutic alternative to compensate for the complications of the appearance of resistance.

Preprint ARTICLE | doi:10.20944/preprints202009.0227.v1

Mosaic and Generalized Forms of Keratinopathic Ichthyoses

Gianluca Tadini, Sophie Guez, Michela Brena

Subject: Medicine And Pharmacology, Dermatology Keywords: keratin 1; keratin 2; keratin 10; epidermolytic ichthyosis; keratinopathic ichthyoses; congenital reticular ichthyosiform erythroderma; ichthyosis en confetti; revertant mosaicism; epidermolytic nevus, mosaicism

Online: 10 September 2020 (07:52:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202302.0429.v1

The Dawning of a New Enterprise: RNA Therapeutics for the Skin

Rachel Kieser, Shaheerah Khan, Nada Bejar, Daniel Kiss

Subject: Medicine And Pharmacology, Dermatology Keywords: RNA therapeutics; skin; mRNA therapeutics; siRNA therapeutics; antisense oligonucleotide ther-apeutics; ASO; melanoma; hypertrophic scars; wound healing; dermatology

Online: 27 February 2023 (01:53:06 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202304.0775.v1

Guided Superficial Enhanced Fluid Fat Injection (SEFFI) Procedures for Facial Rejuvenation: An Italian Multicenter Retrospective Case Reports

Gennai Alessandro, Monica Baldessin, Fabrizio Melfa, Bruno Bovani, Alessandra Camporese, Barbara Claysset, Mattia Colli, Alberto Diaspro, Rosalba Russo, Placido Strano, Daniele Bollero, Guido Capparè, Alessandro Casadei, Giovanni Gallo, Domenico Piccolo, Giovanni Salti, Piero Tesauro

Subject: Medicine And Pharmacology, Dermatology Keywords: facial rejuvenation; Stromal Vascular Fraction; adipose derived mesenchymal stem cells; autologous adipose tissue graft; Superficial Enhanced Fluid Fat Injection; clinical regeneration applications

Online: 23 April 2023 (05:01:28 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202307.0971.v1

Complementary Use of a Next-Generation Emollient Plus and Pimecrolimus in Atopic Dermatitis: A Case Report

Tiago Torres

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic dermatitis; emollient plus cream; topical corticosteroids; topical calcineurin inhibitors; case report

Online: 14 July 2023 (09:18:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202403.0495.v1

Unlocking the Power of Light on the Skin: A Comprehensive Review on Photobiomodulation

María Luisa Hernández-Bule, Jorge Naharro-Rodriguez, Stefano Bacci, Montserrat Fernández-Guarino

Subject: Medicine And Pharmacology, Dermatology Keywords: photobiomodulation; dermatology; laser; photodynamic therapy; LED

Online: 8 March 2024 (06:27:08 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0458.v1

Pathophysiology of Atopic Dermatitis in Different Ethnic Groups

Andrea Chiricozzi, Martina Maurelli, Laura Calabrese, Ketty Peris, Giampiero Girolomoni

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic eczema; dermatitis; allergy; itch; skin disease; treatment; prevention; epidemiology; ethnic differences; cellular; molecular; immunological; physiological therapeutic

Online: 27 February 2023 (08:30:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0364.v1

Efﬁcacy and Safety of Phaseolus angularis L for. as Anti-aging Therapy in Healthy Skin: A Single-Center, Randomized, Double-Blind, Placebo-Controlled Study

Sarang Oh, Jeehaeng Jeong, Xiangji Jin, Myeongju Kim, Shengdao Zheng, Tae-Hoo Yi

Subject: Medicine And Pharmacology, Dermatology Keywords: Phaseolus angularis seed extract (PASE); anti-aging; health skin, cosmetic products

Online: 20 December 2022 (09:03:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.2097.v1

Progress in Wound Healing Products Based on Natural Compounds, Stem Cells and MicroRNA-Based Biopolymers in the European, USA, and Asian Markets: Opportunities, Barriers, and Regulatory Issues

Girish Kumar Srivastava, Sofía Martínez Rodríguez, Nur Izzah Md Fadilah, Gavin Markey, Daniel Looi Qi Hao, Priyank Shukla, Mh Busra Fauzi, Fivos Panetsos

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin injuries; Therapy; Caring; Natural Materials; Regulatory Issues; ISO

Online: 31 July 2023 (10:38:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1632.v1

The Efficacy of a Novel Compound from Bovine Milk Colostrum Exosomes and Its Growth Factors in Enhancing the Process of Wound Healing

Mojgan Najafzadeh, Shohreh Jafarinejad, Adi Baumgartner, Jacobo Elies Gomez

Subject: Medicine And Pharmacology, Dermatology Keywords: Bovine Colostrum; Wound healing; Repair; Chronic wound

Online: 23 January 2024 (07:27:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0583.v1

Cosmetics Pattern Map Considering their Effects on Skin Microbiota-Principal Component Analysis of the Effects on Short Chain Fatty Acid Production by Skin Microbiota Staphylococcus epidermidis

Kurumi Tanabe, Chihiro Moriguchi, Nao Fujiyama, Yuka Shigematsu, Nanami Haraguchi, Yuto Hirano, Huanghuang Dai, Shigeki Inaba, Yoshihiro Tokudome, Hiroshi Kitagaki

Subject: Medicine And Pharmacology, Dermatology Keywords: cosmetics; skin microbiota; Staphylococcus epidermidis; lactic acid; PCA

Online: 8 June 2023 (04:09:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0317.v1

A Bibliometric Analysis of Syphilis Research in Last Hundred Years in Scopus Database (1921-2021)

Sagnik Chakraborty, Nupur Mahajan, Sivaraman Balaji, Kuldeep Nigam, Sumit Aggarwal

Subject: Medicine And Pharmacology, Dermatology Keywords: Bibliometric analysis; Scopus database; Syphilis; Sexually Transmitted Infections; Public Health; Research; Global

Online: 21 September 2022 (07:14:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0315.v1

Treatment of Melasma on Darker Skin Types: a Scoping Review

Nomakhosi Mpofana, Buyisile Chibi, Tronel Visser, Michael Paulse, Avenal Jane Finlayson, Shanaz Ghuman, Nceba Gqaleni, Ahmed Mohammed Hussain, Ncoza Cordelia Dlova

Subject: Medicine And Pharmacology, Dermatology Keywords: Melasma; Treatment; Darker skin types; Fitzpatrick skin types IV-VI; mapping review

Online: 19 December 2022 (03:45:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1369.v1

Protective Effect of Amaranthus cruentus Seed Oil on the UVA Radiation-Induced Apoptosis in Human Skin Fibroblasts

Katarzyna Wolosik, Magda Chalecka, Jerzy Palka, Arkadiusz Surazynski

Subject: Medicine And Pharmacology, Dermatology Keywords: UVA radiation; oxidative stress; dermal fibroblasts; apoptosis; antioxidant; Amaranthus cruentus seed oil; sun-protective substance; pharmacy; cosmetology

Online: 19 May 2023 (03:49:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.2196.v1

A Comprehensive Review of the Cosmetic Application of Kojic Acid Dipalmitate: Kojic Acid Derivative with Improved Properties

Angreni Ayuhastuti, Insan Sunan Kurniawan Syah, Sandra Megantara, Anis Yohana Chaerunisaa

Subject: Medicine And Pharmacology, Dermatology Keywords: kojic acid dipalmitate; cosmeceuticals; cosmeceuticals

Online: 28 December 2023 (14:39:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.1458.v1

Efficacy and Tolerability of a Microneedling Device plus Exosomes for Treating melasma

Ilaria Proietti, Chiara Battilotti, Francesca Svara, Carlotta Innocenzi, Alessandra Spagnoli, Concetta Potenza

Subject: Medicine And Pharmacology, Dermatology Keywords: Melasma; hyperpigmentation; exosomes; RSCEs; microneedling.; mMASI; GAIS

Online: 26 February 2024 (14:17:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.1261.v1

Sharp Resection of Hypergranulation Tissue from Only One Sulcus in a Bilateral Stage 3 Onychocryptosis: A Case Report

Ian Reilly

Subject: Medicine And Pharmacology, Dermatology Keywords: Ingrown toenail; onychocryptosis; hypergranulation tissue; proud flesh; sharp resection

Online: 30 April 2023 (04:48:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0617.v1

Plaque Psoriasis: Effectiveness and Therapeutic Safety Using a Topical Cream of Natural Origin Quasi–experimental Clinical Trial

Elizabeth Maria Benites, Esmeralda Carrillo, Martha Heras

Subject: Medicine And Pharmacology, Dermatology Keywords: Psoriasis; erythema; infiltration; desquamation; itching; PASI; SBA

Online: 20 April 2023 (07:34:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0150.v1

Development of a Low-Temperature Process for the Formulation of Nanoemulsion-Gel Encapsulating Essential Oil: Investigation on the Wound Healing Effect

Badr Bahloul, Enis Ben Bnina, Assia Hamdi, Luis Castillo, Dhaou Baccar, Nesrine Kalboussi, Aymen Abbassi, Nathalie Mignet, Guido Flamini, José Vega-Baudrit

Subject: Medicine And Pharmacology, Dermatology Keywords: nanoemulsion; wound healing effect; essential oil

Online: 2 August 2023 (08:29:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0257.v1

Ciprofloxacin-Loaded Polyvinylpyrrolidone Foils for the Topical Treatment of Wound Infections with Methicillin-Resistant Staphylococcus aureus (MRSA)

Fiorenza Rancan, Jana Jurisch, Sabrina Hadam, Annika Vogt, Ulrike Blume-Peytavi, Ilker S. Bayer, Marco Contardi, Christoph Schaudinn

Subject: Medicine And Pharmacology, Dermatology Keywords: wound dressing; drug delivery; organ culture, infection models, ciprofloxacin, infected wounds

Online: 5 June 2023 (08:09:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0800.v1

New and Emerging Biological and Oral/Topical Small-Molecule Treatments for Psoriasis

Elena Carmona-Rocha, Lluís Rusiñol, Lluís Puig

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; oral therapies; topical therapies; biologics; Jak inhibitors; PDE4 inhibitors; systemic treatment; IL-17 inhibitors; IL-23 inhibitors; tapinarof; roflumilast

Online: 10 January 2024 (08:49:06 CET)

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Preprint REVIEW | doi:10.20944/preprints202309.0059.v1

Enhancing Skin Anti-Aging Through Healthy Lifestyle Factors

Helen Knaggs, Edwin D Lephart

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin; Anti-aging; Health, Lifestyle Factors, Diet, Sleep, Exercise, Social interactions, Polyphenols, Vitamins

Online: 1 September 2023 (10:30:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0630.v1

Clinical‑Epidemiological Characteristics of Hidradenitis Suppurativa: A Retrospective Cohort Study

Anan Hammud, Emily Avitan-Hersh, Ziad Khamaysi

Subject: Medicine And Pharmacology, Dermatology Keywords: Hidradenitis Suppurativa; Adalimumab (Humira); Hurley Stages; Arabs and Jews

Online: 20 April 2023 (08:14:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0193.v1

Novel Data Analyses Explain the Birth-Cohort Phenomenon of Peptic Ulcers

Simon Xin Min Dong

Subject: Medicine And Pharmacology, Dermatology Keywords: peptic ulcers; birth-cohort phenomenon; superposition mechanism; psychosomatic disease; psy-chological stress; crucial events

Online: 13 February 2023 (02:06:22 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202308.0124.v1

Wound-Healing Effects of an Exosome-Rich Conditioned Medium from Human Amniotic Membrane Stem Cells

Chan Ho Noh, Sangryong Park, Hye-Rim Seong, Ah-young Lee, Khan-Erdene Tsolmon, Dong Ho Geum, Soon-Cheol Hong, Tae Myoung Kim, Ehn-Kyoung Choi, Yun-Bae Kim

Subject: Medicine And Pharmacology, Dermatology Keywords: amniotic membrane stem cell; exosome-rich conditioned medium (ERCM); growth factor; neurotrophic factor; wound healing; keratinocyte proliferation; collagen synthesis

Online: 2 August 2023 (07:32:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0301.v1

Remote Monitoring of Canine Patients Treated for Pruritus during the COVID Pandemic in Florida Using a 3-D Accelerometer

Michael Canfield, Robert P. Lavan, Timberly Canfield, Gal Gingold, Jennifer Thomas, Bridgette Sampeck, Tonya Springer, Rob Armstrong

Subject: Medicine And Pharmacology, Dermatology Keywords: pruritus; 3D-accellerometer; monitoring; allergic skin disease; canine atopic dermatitis

Online: 5 June 2023 (10:13:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.2097.v2

Progress in Wound Healing Products based on Natural Compounds, Stem Cells and MicroRNA-based Biopolymers in the European, USA, and Asian Markets: Opportunities, Barriers, and Regulatory Issues

Girish Kumar Srivastava, Sofía Martínez Rodríguez, Nur Izzah Md Fadilah, Daniel Looi Qi Hao, Gavin Markey, Priyank Shukla, Mh Busra Fauzi, Fivos Panetsos

Subject: Medicine And Pharmacology, Dermatology Keywords: Skin injuries; Therapy; Caring; Natural Materials; Regulatory Issues; ISO

Online: 22 November 2023 (07:43:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0039.v1

The Impact of Ultraviolet Radiation on Energy Metabolism and Metabolic Disorders in Mice: Mechanisms and Implications

Qing-Ling Quan, Kyeong-No Yoon, Ji Su Lee, Eun Ju Kim, Dong Hun Lee

Subject: Medicine And Pharmacology, Dermatology Keywords: metabolic disorders; nitric oxide; obesity; ultraviolet; vitamin D

Online: 2 March 2023 (09:44:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0137.v1

Elucidating the Role of Santalol as A Potent Inhibitor of Tyrosinase: In Vitro and In Silico Approaches

Nabeel Ali, Zainy Zehra, Anas Shamsi, Md Amjad Beg, Zahoor Ahmad Parray, Israil ., Md. Ali Imam, Naseem A. Gaur, Md Imtaiyaz Hassan, Anis Ahmad Chaudhary, Hassan A. Rudayni, Mohammed Ibrahim Alghonaim, Sulaiman A. Alsalamah, Asimul Islam

Subject: Medicine And Pharmacology, Dermatology Keywords: Mushroom tyrosinase; Melanogenesis; Tyrosinase inhibitor; Multi-spectroscopic techniques; Natural compounds; tyrosinase inhibitor

Online: 8 November 2022 (02:23:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0395.v1

An Investigation into The Acute and Subacute Toxicity of Extracts of Cassipourea Flanaganii Stem Bark in vivo

Nomakhosi Mpofana, John Kudakwashe Chipangura, Michael Paulse, Bert Mohr, Nceba Gqaleni, Celenkosini Thembelenkosini Nxumalo, Ncoza Cordelia Dlova, Ahmed A. Hussein, Neil R. Crouch

Subject: Medicine And Pharmacology, Dermatology Keywords: cassipourea flanaganii; hypermelanosis; melasma; toxicity

Online: 17 April 2023 (04:11:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1665.v1

Generalized Rash in Severe Hospitalized COVID Patients: Correlation between Histological Examination, Drug Intake, Blood Interleukins Profileand Long-Term Follow-Up

Montserrat Fernández-Guarino, Vivian Stewart, Diego Fernández-Nieto, Carmen Moreno Garcia del Real, David Gonzalez de Olano, Carolina Blanco, Emilio Solano-Solares, Belen De la Hoz Caballer, Javier Martínez-Botas, Maria Laura Garcia-Bermejo, Ana Andrés-Martín

Subject: Medicine And Pharmacology, Dermatology Keywords: skin; COVID infection; cytokines; SARS-CoV-2

Online: 25 September 2023 (09:37:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0035.v1

Clinical Assessment of Specifically Formulated Creams for Oncology: Case Series

Jordi Esquirol Caussa, José Luis Ribes Bernal

Subject: Medicine And Pharmacology, Dermatology Keywords: breast cancer; radiodermatitis; radiotherapy; primary prevention

Online: 2 March 2023 (06:33:07 CET)

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INTRODUCTION: Radiation dermatitis is a common sequela of radiotherapy (RT) that can affect up to 95% of patients, developing moderate to severe skin reactions in up to 30% of them. Variation in fractionation or administration methods may reduce the incidence and severity of radiation dermatitis. It is considered that topical use of preparations holding certain preservatives, surfactants, additives, oils, and impurities should be avoided in cancer patients. In clinical practice, creams of different compositions are used, with and without Epidermal Growth Factor (EFG). OBJECTIVE: To analyze the effectiveness of three creams of different compositions for the control of symptoms and skin side effects of RT.METHODS: A pilot study comparing three treatment groups (HR, HU, and RS creams) during the RT program and with a follow-up of 2 weeks thereafter. Study variables: fractionation, Patient-Observer scale, Maxidex (elasticity, hydration, melanin, erythema).RESULTS: The pilot study sample included 15 patients (5 for each group), so the results were not statistically significant. There were no undesirable side effects to the application of the creams under study and compliance and tolerance were excellent.Regardless of fractionation, RS cream appears to be more effective in controlling symptoms during RT, while HU cream may control them more effectively after the RT regimen is completed.During RT, in hypofractionated therapies, the RS cream seems to preserve elasticity, hydration, and hyperpigmentation allowing erythema that could increase skin repair processes. After the RT is finished, the HR cream further improves elasticity and allows the appearance of erythema.In normofractionated therapies during RT all creams seem to have comparable results in the four cutaneous components analyzed; after completion of RT, HR cream appears to better control hydration and hyperpigmentation.CONCLUSIONS: All the creams analyzed have good control of symptoms and the appearance of the skin during and after RT. The prescription of one or another composition should be done individually according to the cutaneous and clinical particularities of each patient. A study with experimental design is needed to analyze the statistical significance of the differences between the creams analyzed.

Preprint ARTICLE | doi:10.20944/preprints202304.0545.v1

Potential Use of Guarana-Loaded Liposomes in Topical Applica-Tions: Toxicity Profile Assessment Using Different Skin Cell Lines

Isabel Roggia, Patrícia Gomes, Ana Julia Figueiro Dalcin, Aline Ferreira Ourique, Ivana Beatrice Mânica Da Cruz, Euler Esteves Ribeiro, Montserrat Mitjans, Maria Pilar Vinardell

Subject: Medicine And Pharmacology, Dermatology Keywords: Paullinia cupana; natural products; nanoparticles; stability; cytotoxicity; cell culture

Online: 19 April 2023 (04:52:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0351.v1

Bile Duct Double Ligation and Microdialysis in Rats: An Animal Model of Liver Fibrosis

Giuliana Scarpati, Marco Corona, Ornella Piazza

Subject: Medicine And Pharmacology, Dermatology Keywords: liver fibrosis; liver cirrhosis; bile duct ligation; animal model

Online: 21 February 2023 (04:21:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202305.0628.v1

Nanotechnology-Based Topical Delivery of Natural Products for the Management of Atopic Dermatitis

Mário Pedro Marques, Carla Varela, Laura Mendonça, Célia Cabral

Subject: Medicine And Pharmacology, Dermatology Keywords: atopic dermatitis; skin inflammation; natural products; nanotechnology; topical delivery

Online: 9 May 2023 (09:45:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1290.v1

Is Cutaneous T-Cell Lymphoma Caused by Ultraviolet Radiation? Comparison of UV Mutational Signatures Between Malignant Melanoma and Mycosis Fungoides.

Robert Gniadecki, Sandra O’Keefe, Dylan Hennessey, Aishwarya Iyer

Subject: Medicine And Pharmacology, Dermatology Keywords: cutaneous T-cell lymphoma; ultraviolet; mutation signatures; malignant melanoma, whole exome sequencing

Online: 18 May 2023 (07:36:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0099.v1

Slip, Slop, Slap, Slide, Seek and Sport: A Systematic Scoping Review of Sun Protection in Sport in Australasia

Sarah Kym Morton, Simone Lee Harrison

Subject: Medicine And Pharmacology, Dermatology Keywords: Clothing; Health Promotion; Skin Cancer Prevention; Sport; Ultraviolet Radiation

Online: 7 November 2022 (02:06:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0539.v1

Efficacy and Safety of LASERs in Treatment of Dermal Pigmentation: A Five-Year Experience of 122 patients from North India

Suruchi Garg, Diksha Garg, Bhavni Oberoi, Geeta Sharma

Subject: Medicine And Pharmacology, Dermatology Keywords: Pigmentation; Melasma; Q switch laser; tattoo; birth marks

Online: 10 October 2023 (10:23:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1290.v1

The Genetic Susceptibility to Psoriasis and the Relationship of Linked Genes to our Treatment Options

Heli A. Patel, Rishab Revankar, Sofia T. Pedroza, Shaveonte Graham, Steven R. Feldman

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; genetics; biologics; cytokines; interleukins; small molecules; JAK-STAT

Online: 19 June 2023 (04:59:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0271.v1

Novel Data Analyses Explain the Seasonal Variation of Peptic Ulcers

Simon Xin Min Dong

Subject: Medicine And Pharmacology, Dermatology Keywords: peptic ulcer; seasonal variation; superposition mechanism; climate; work; vacation; psychosomatic disease; psychological stress

Online: 16 February 2023 (04:52:59 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0259.v1

Phosphodiesterase 4 Inhibition in the Management of Psoriasis

Erika L Crowley, Melinda J Gooderham

Subject: Medicine And Pharmacology, Dermatology Keywords: psoriasis; PDE4 inhibitor; apremilast; roflumilast; crisaborole; clinical trials; review

Online: 6 November 2023 (07:07:05 CET)

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Preprint REVIEW | doi:10.20944/preprints202211.0345.v1

Current Status of Tungiasis in Endemic Areas. Prevalence, Risk Factors, Prevention

Valeri Velev

Subject: Medicine And Pharmacology, Dermatology Keywords: Tungiasis; Tunga penetrans; neglected tropical diseases; epidemiology

Online: 18 November 2022 (02:48:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1089.v1

Contact Dermatitis Due to Hair Care Products: A Comprehensive Review

Marta Cebolla Verdugo, Juan Pablo Velasco Amador, Francisco José Navarro Triviño

Subject: Medicine And Pharmacology, Dermatology Keywords: contact dermatitis; hair; cosmetics; patch test

Online: 20 February 2024 (11:25:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1023.v1

The Potential Role of Stem Cells in Wound Healing: A Systematic Review

Banu Farabi, Katie Roster, Rahim Hirani, Katharine Tepper, Mehmet Fatih Atak, Bijan Safai

Subject: Medicine And Pharmacology, Dermatology Keywords: stem cells; chronic wound; wound healing; dermatology

Online: 19 February 2024 (08:19:53 CET)

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Introduction: Wound healing is a complex cascade involving the orchestration of inflammatory cells, skin fibroblasts, keratinocytes, and endothelial cells. These cells achieve tissue repair through an interchange of cytokines and growth factors through a controlled inflammation, angiogenesis, and remodeling process. Disruptions in the wound-healing process by comorbid conditions lead to significant morbidity and mortality. Stem cell therapy has emerged as a new strategy to facilitate the wound healing process. Stem cells harvested from different sources can be used for wound repair and regeneration (endothelial progenitor cells, bone marrow, adipose tissue, dermal and inducible pluripotent stem cells). We aimed to review clinical, translational, and primary literature on stem cell therapies in chronic wounds and summarize practical clinical applications to dermatological care. Materials and Methods: A comprehensive search of Pubmed, Embase, Web of Science, Google Scholar, and Cochrane Library was conducted for studies relating to stem cells and wound healing. Duplicate results were removed using Covidence. Titles and abstracts were screened by two independent researchers (BF and KR), with discrepancies resolved through discussion and mutual agreement. Articles were excluded if they were review-type or commentary-type articles. Results: A total of 22,454 articles were retrieved from the search. Deduplication removed 905, and automation removed an additional 18,363 articles. After an initial screening of titles and abstracts, 170 articles remained. Full-text screening resulted in an additional 126 articles being removed, leaving 44 included studies. Discussion: Stem cells used for wound repair and regeneration include endothelial progenitor stem cells and adult stem cells, in the forms of bone marrow-derived mesenchymal stem cells, adipose tissue stem cells, and inducible pluripotent stem cells. Among these sources, adipose tissue-derived mesenchymal stem cells (AD-MSCs) are ideally used due to the abundant supply of fat tissue, ease of isolation, extensive proliferative capacities ex vivo, and their ability to secrete pro-angiogenic factors. AD-MSCs have been used to enhance wound healing in peripheral arterial disease, diabetic wounds, hypertensive ulcers, bullous diabeticorum, venous ulcers, and postsurgical wounds after Mohs micrographic surgery. These cells have been delivered to the tissue topically, with scaffolds, combined with plasma-rich proteins, and through atelocollagen in various human studies. These approaches, when combined with local wound care practices, resulted in decreased pain, shorter wound healing times, and better cosmesis. Conclusions: Stem cell transplantation is a potential therapeutic approach in the wound healing process. Transplanted stem cells do not only differentiate into multiple skin cell types but also provide cytokine and growth factors required for wound healing resulting in increased angiogenesis. Thus, this approach may be regarded as an attractive option for intractable wounds that cause major clinical problems, especially chronic lower leg wounds. It can also be used after Mohs micrographic surgery for defects left to heal by secondary intention. Stem cell application may reduce the overall cost burden on the healthcare system and improve the quality of life for patients.

Preprint CONCEPT PAPER | doi:10.20944/preprints202302.0297.v1

Novel Data Analyses Address the African Enigma and Controversies Surrounding the Roles of Helicobacter pylori in Peptic Ulcers

Simon Xin Min Dong

Subject: Medicine And Pharmacology, Dermatology Keywords: Helicobacter pylori; peptic ulcer; etiology; illusion; philosophy; African enigma

Online: 17 February 2023 (06:33:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202303.0110.v1

The Current Role and Future Applications of Machine Perfusion in Liver Transplantation

Sebastian Manuel Staubli, Carlo D. L. Ceresa, Jörg-Matthias Pollok

Subject: Medicine And Pharmacology, Dermatology Keywords: Liver transplantation; organ perfusion

Online: 6 March 2023 (15:23:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.0554.v1

Alopecias: Practical Tips For The Management Of Biopsies And Main Diagnostic Clues For The General Pathologist And Dermatopathologist

Fernando Pinedo Moraleda, Belen Tristan Martin, Giulia Greta Dradi

Subject: Medicine And Pharmacology, Dermatology Keywords: alopecia; cicatricial alopecia; follicular cycle; follicle histopathology; hair; hair loss; noncicatricial alopecia; nonscarring alopecia; scarring alopecia

Online: 10 July 2023 (08:53:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.0998.v1

Insulin Resistance in Patients with Acne Vulgaris– Original Paper and Systematic Review

Michalina Gruszczyńska, Anna Sadowska-Przytocka, Weronika Szybiak, Barbara Więckowska, Katarzyna Lacka

Subject: Medicine And Pharmacology, Dermatology Keywords: acne vulgaris; insulin resistance; HOMA-IR; resistant acne

Online: 14 July 2023 (11:12:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0724.v1

Seaweeds Calliblepharis jubata and Fucus vesiculosus Pigments: Antidermatophytic Activity

Louisa Gomes, João Cotas, Chantal Fernades, Teresa Gonçalves, Leonel Pereira

Subject: Medicine And Pharmacology, Dermatology Keywords: Seaweeds; pigments; natural extracts; antifungal activity; UV Spectrophotometry; TLC; FTIR

Online: 11 October 2023 (10:39:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0164.v1

Role of the Gut Liver Axis in the Pathobiology of Cholangiopathies: Basic and Clinical Evidence

Maria Consiglia Bragazzi, Rosanna Venere, Anthony Vignone, Domenico Alvaro, Vincenzo Cardinale

Subject: Medicine And Pharmacology, Dermatology Keywords: mucosal barrier; cholangiocarcinoma; gut-liver-axis; primay biliary cholangitis; primay sclerosing cholangitis

Online: 9 March 2023 (03:12:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.2181.v1

Skin Lesions with Loss of Tissue and Cutaneous-Onset Sepsis: The Skin Infection-Sepsis Relationship

Adriana Ionela Pătrașcu, Dan Vâță, Doinița Temelie-Olinici, Mădălina Mocanu, Dumitriţa Lenuţa Guguluş, Mădălina Marinescu, Liviu Stafie, Bogdan Marian Tarcău, Ioana Adriana Popescu, Ioana Creţu, Carmen Diana Cimpoeşu, Laura Gheucă-Solovăstru

Subject: Medicine And Pharmacology, Dermatology Keywords: skin lesions with loss of tissue; cutaneous-onsetsepsis; acute infections; skin microbiome

Online: 31 January 2024 (08:08:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.0472.v1

Acne Transcriptomics: Fundamentals in Acne Pathogenesis and Isotretinoin Treatment

Bodo C. Melnik

Subject: Medicine And Pharmacology, Dermatology Keywords: acne; apoptosis; FoxO1; FoxO3; isotretinoin; mTORC1; p53; pathogenesis; therapy; transcriptomics

Online: 9 October 2023 (07:48:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1446.v1

The Escalating Specter of Antifungal Resistance in Superficial Mycoses

Ahmed Kadry Eltokhy, Ali Mohamed El-Abbasi, Mohamed Kadri Eltoukhi, Sidi Mohammed lahbib Seddiki, Mahmoud Afif Ghannoum

Subject: Medicine And Pharmacology, Dermatology Keywords: Antifungal resistance; superficial mycoses; antifungal susceptibility; Terbinafine resistant Trichophyton

Online: 19 December 2023 (15:57:37 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.0461.v1

Polymorphisms of the GCLC Gene Are Novel Genetic Markers For Susceptibility To Psoriasis Associated With Alcohol Abuse And Cigarette Smoking

Ekaterina Efanova, Olga Bushueva, Roman Saranyuk, Anna Surovtseva, Mikhail Churnosov, Maria Solodilova, Alexey Polonikov

Subject: Medicine And Pharmacology, Dermatology Keywords: Psoriasis; genetic susceptibility; oxidative stress; glutathione; glutamate cysteine ligase; GCLC; single nucleotide polymorphism; cigarette smoking; alcohol abuse; gene–environment interactions

Online: 8 May 2023 (08:03:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1810.v1

Lines and Dots Technique: A Novel Precision Approach in BoNT-A Administration for Horizontal Forehead Lines

Kamal Alhallak

Subject: Medicine And Pharmacology, Dermatology Keywords: Botulinum Toxin Type A (BoNT-A); Cosmetic Dermatology; Frontalis Muscle; Forehead Lines; Supraorbital Nerve; Supratrochlear Nerve

Online: 29 November 2023 (07:27:32 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0861.v1

The Economic Burden of Alopecia Areata in Romania

Stefan Strilciuc, Rodica Olteanu, Rozalina Lăpădatu, Diana-Alecsandra Grad, Cristian Vlădescu, Alin Codruț Nicolescu

Subject: Medicine And Pharmacology, Dermatology Keywords: alopecia areata, cost of illness, economic burden

Online: 11 January 2024 (10:29:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202404.0109.v1

Understanding the Importance of Daily Imaging in the Treatment of Non-Melanoma Skin Cancer with Image Guided Superficial Radiation Therapy

Jeffrey Stricker, Janine Hopkins, Aaron Farberg, Peyton Harris

Subject: Medicine And Pharmacology, Dermatology Keywords: non melanoma skin cancer; basal cell carcinoma; squamous cell carcinoma; image guided superficial radiation therapy; superficial radiation therapy; image guided radiation therapy ;

Online: 1 April 2024 (14:58:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.0350.v1

Involvement of Par-2 in the Induction of Matrix Metalloproteinase-2 by Activated Protein C in Cutaneous Wound Healing

Sohel M Julovi, Kelly McKelvey, Nikita Minhas, Agnes Chan, Meilang Xue, Christopher J. Jackson

Subject: Medicine And Pharmacology, Dermatology Keywords: Activated protein C; cutaneous wound healing; murine; matrix metalloproteinase-2, 9; and protease activated receptor-2

Online: 12 December 2023 (08:26:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0242.v1

Influence of Dose, Particle Size &Amp; Concentration on Dermal Penetration Efficacy of Curcumin

Em-on Chaiprateep, Sabrina Wiemann, Ralph W Eckert, Christian S. Raab, Soma Sengupta, Cornelia M. Keck

Subject: Medicine And Pharmacology, Dermatology Keywords: nanocrystals; curcumin; aqueous meniscus; dermal penetration; ex-vivo model; porcine skin

Online: 5 October 2023 (02:10:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.0397.v1

Exploring the Pathogenesis and Mechanism-Targeted Treatments of Rosacea: Previous Understanding and Updates

Chengqian Chen, Peiru Wang, Linglin Zhang, Xiaojing Liu, Haiyan Zhang, Yajing Cao, Xiuli Wang, Qingyu Zeng

Subject: Medicine And Pharmacology, Dermatology Keywords: Rosacea; inflammation; inflammatory skin disease; pathogenesis; therapeutic strategies; treatment options

Online: 6 July 2023 (09:02:30 CEST)

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Medicine and Pharmacology