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Preprint ARTICLE | doi:10.20944/preprints202306.0387.v1

A Comparative Study on Kinetics Performances of BSA-gold Nanozymes for Nanozyme-Mediated Oxidation of 3,3’,5,5’-Tetramethylbenzidine and 3,3’-Diaminobenzidine

Saeed Reza Hormozi Jangi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: kinetics performances; BSA-gold nanozymes; 3,3’,5,5’-thetramethylbenzidine; 3,3’-diaminobenzidine

Online: 6 June 2023 (05:41:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0187.v1

Electrochemical Wearable Biosensors and Bioelectronic Devices Based on Hydrogels: Mechanical Properties and Electrochemical Behavior

Mohsen Saeidi, Hossein Chenani, Mina Orouji, MahsaSadat Adel Rastkhiz, Nafiseh Bolghanabadi, Shaghayegh Vakili, Zahra Mohamadnia, Amir Hatamie, Abdolreza (Arash) Simchi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Flexible biosensors; Electroactive hydrogel; Biocompatible polymer; Electrochemistry; Mechanical behavior

Online: 2 June 2023 (10:45:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2267.v1

Spectrophotometric Determination of N-Acetyl-L-Cysteine in Pharmaceutical Formulations by Flow Injection and Sequential Injection Analysis: Comparison of the Methods

Maja Biocic, Deni Karabatic, Dea Tomic, Lea Kukoc -Modun, Darko Modun

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: N-acetyl-L-cysteine; flow injection analysis; sequential injection analysis; spectrophotometric determination; pharmaceuticals

Online: 31 May 2023 (14:37:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2237.v1

Development of a Liquid-Liquid Extraction Method to Study the Temporal Production of D-series Resolvins by Head Kidney Cells from Atlantic Salmon (Salmon salar) Exposed to Docosahexaenoic Acid

Pedro Araujo, Sarah Iqbal, Aleksander Arnø, Marit Espe, Elisabeth Holen

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Resolvins; Liquid chromatography quadrupole mass spectrometry; Atlantic salmon; Head kidney cells; Liquid-liquid extraction

Online: 31 May 2023 (11:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2225.v1

Molecular Taphonomy of Heme: Chemical Degradation of Hemin under Presumed Fossilization Conditions

Mariam Tahoun, Marianne Engeser, Luca Svolacchia, P. Martin Sander, Christa E. Müller

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: heme; porphyrin; paleontology; fossilization; molecular taphonomy; preservation; mass spectrometry; di-nosaurs; oxidation; hematinic acid

Online: 31 May 2023 (10:43:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2106.v1

Evaluating the Effect of Shelf-Storage, Daylight, and Air Oxygen on the Peroxidase-like Activity of Unmodified Silver Nanoparticles

Saeed Reza Hormozi Jangi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: unmodified silver nanoparticles; peroxidase-like activity; air oxygen; daylight; shelf-life

Online: 30 May 2023 (10:33:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2000.v1

Feather-Like Gold Nanostructures Anchored onto 3D-Mesoporous Laser-Scribed Graphene: A Highly Sensitive Platform for Enzymeless Glucose Electrochemical Detection in Neutral Media

Achraf Berni, Aziz Amine, Juan José García-Guzmán, Laura Cubillana-Aguilera, José María Palacios-Santander

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Non-enzymatic Detection; Laser-scribed Graphene; Gold Nanostructures; Neutral medium; Disposable sensor; Glucose sensor

Online: 29 May 2023 (08:54:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1685.v1

Isotope Detection in Microwave-Assisted Laser-Induced Plasma

Ali M. Alamri, Jan Viljanen, Philip Kwomg, Zeyad T. Alwahabi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: LIBS; microwave; isotope; plasma; emission

Online: 24 May 2023 (04:17:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1494.v1

Investigation of the Gold Nanoparticles Synthesis, Mechanism and Characterization Using the Turkevich Method

Arnaldo César Pereira, Ana E.F. Oliveira, Mayra A. C. Resende, Lucas Franco Ferreira

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Gold nanoparticles; Synthesis; Nanomaterial; Turkevich method; characterization

Online: 22 May 2023 (10:03:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1350.v1

Yuanyuan Liu, Koichi Jeremiah Aoki, Jingyuan Chen

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: heterogeneous kinetics; Butler-Vomer type; delay of the double layer capacitance; frequency dispersion; chnoroanperometry; ferrocenyl derivative; lowered diffusion-controlled current; time-dependent surface concentration; negatively capacitive current

Online: 18 May 2023 (14:22:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1201.v1

A New HPLC-UV Method Using Hydrolyzation with Sodium Hydroxide for Quantitation of Trans-p-hydroxycinnamic Acid and Its Esters in the Leaves of Ligustrum Robustum

Shi-Hui Lu, Xiao-Na Liang, Xiao-Jin Nong, Ran Chen, Xiu-Xia Li

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: trans-p-hydroxycinnamic acid; esters; Ligustrum robustum; HPLC-UV; hydrolyzation; sodium hydroxide; quantification

Online: 17 May 2023 (05:54:10 CEST)

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The leaves of Ligustrum robustum have been applied as Ku-Ding-Cha, a functional tea to clear heat and remove toxins; and served as a folk medicine to deal with diabetes, obesity, and hypertension. Trans-p-hydroxycinnamic acid and its esters, which were isolated from the leaves of L. robustum, might be a new resource to prevent diabetes and its complications because of their strong -glucosidase and fatty acid synthase (FAS) inhibitory activities and antioxidant effect. However, the quantitative analytical method for trans-p-hydroxycinnamic acid and its esters in the leaves of L. robustum hasn’t been reported so far. In addition, it was difficult and troublesome to analyze no less than 34 trans-p-hydroxycinnamic acid esters by usual HPLC. Therefore, a new HPLC-UV method using hydrolyzation with sodium hydroxide for quantitation of trans-p-hydroxycinnamic acid and its esters in the leaves of L. robustum was developed in the present study. The optimal hydrolyzation conditions were as follows: 1 mL sodium hydroxide aqueous solution (1 M) was added into 1 mL the extract of L. robustum and incubated at 80 °C for 2 h , and then 1 mL hydrochloride (1 M) solution was added. HPLC analysis was performed in reverse phase mode using a C-18 column, eluting with methanol-0.1% acetic acid aqueous solution (40:60, v/v) in isocratic mode at a flow rate of 1.0 mL/min, and detecting at 310 nm. The analytical method was simple and rapid, which simplified greatly the analytical process. The method was validated in terms of linearity, limit of detection (LOD), limit of quantification (LOQ), precision, and accuracy. High linearity was demonstrated with correlation coefficient of 1.000 for trans-p-hydroxycinnamic acid. The LOD and LOQ values were 1.55 and 4.69 μg/mL, respectively. The relative standard deviations (RSD) of intra-day and inter-day variabilities for trans-p-hydroxycinnamic acid were less than 2%. The percentage recovery of trans-p-hydroxycinnamic acid was 101.2% ± 0.8%. Finally, the proposed method was applied successfully to the determination and comparison of the contents of trans-p-hydroxycinnamic acid and its esters in various extracts of the leaves of L. robustum. The 60%-70% ethanol extracts of L. robustum showed the highest contents of free trans-p-hydroxycinnamic acid (3.96-3.99 mg/g), and the 50%-80% ethanol extracts of L. robustum displayed the highest contents of trans-p-hydroxycinnamic acid esters (202.6-210.6 mg/g). The method can be applied also to the quality control of the products of L. robustum.

Preprint REVIEW | doi:10.20944/preprints202305.1043.v1

New Prospects in the Electroanalysis of Heavy Metals (CD, Pb, Zn, Cu); Development and Application of Innovative Electrode Surfaces

Stella Girousi, Sophia Karastogianni, Vasiliki Keramari

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: heavy metals; modified electrode; electroanalysis; nanoparticles

Online: 15 May 2023 (12:34:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0924.v1

Progress in the Optical Sensing of Cardiac Biomarkers

Cristina Polonschii, Monica Potara, Madalina Iancu, Sorin David, Roberta Maria Banciu, Alina Vasilescu, Simion Astilean

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: cardiovascular diseases; optical assay; biosensors

Online: 12 May 2023 (10:23:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0634.v1

Multivariate Curve Resolution Methodology Applied to the ATR-FTIR Data for Adulteration Assessment of Virgin Coconut Oil

Michele De Luca, Giuseppina Ioele, Fedora Grande, Maria Antonietta Occhiuzzi, Martina Chieffallo, Antonio Garofalo, Gaetano Ragno

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: virgin coconut oil; oil adulteration; Fourier transform infrared; multivariate curve resolution; genetic algorithm; control chart.

Online: 9 May 2023 (10:22:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0509.v1

Sensitivity Enhancement for Separation-Based Analytical Techniques Utilizing Large Volume Injection and Analyte Derivatization for Trace Analysis in Bio-Fluids

Hanan Farouk, Hager Ebrahim, Heba Sonbol, Monika Malak, Maha Kamal, Noha Ibrahim, Ahmed Shawky, Walaa Zarad, Ahmed Emad, Samy Emara

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: separation-based analytical techniques; large volume injection; solid phase enrichment; solid phase analytical derivatization; packed reactor; trace analysis

Online: 8 May 2023 (10:17:13 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0442.v1

Gold Nanoparticle-Based Microfluidics Chips for Capture and Detection of Circulating Tumor Cells

Valber A. Pedrosa, Kangfu Chen, Z. Hugh Fan

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Circulating tumor cells; gold nanoparticles; microfluidics; cell capture

Online: 8 May 2023 (04:41:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0211.v1

Rapid and Sensitive Detection of Polycyclic Aromatic Hydrocarbons in Tea Leaves Using Magnetic Approach

Xiaohan Zhao, Xiao Feng, Jingwen Chen, Lanxin Zhang, Lingzi Zhai, Xi Yu, Ying Xiao

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Polycyclic aromatic hydrocarbons; Tea; Magnetic solid phase extraction; UPLC; Nanoparticles

Online: 4 May 2023 (07:35:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0185.v1

Analysis of Omega-3 (ω-3) Fatty Acid in Indonesia Fish Oils Using Infrared Spectroscopy and Multivariate Data Analysis

Irnawati Irnawati, Anjar Windarsih, Nurrulhidayah A. Fadzilah, Florentinus Dika Octa Riswanto, Abdul Rohman

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: EPA-DHA; marine oils; FTIR spectra; chemometrics; partial least square

Online: 4 May 2023 (04:17:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0942.v1

Low Overpotential Amperometric Sensor using Yb2O3.CuO@rGO Nanocomposite for Sensitive Detection of Ascorbic Acid in Real Samples

Jahir Ahmed, Mohd Faisal, Jari S. Algethami, Mabkhoot A. Alsaiari, Saeed A. Alsareii, Farid A. Harraz

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Ascorbic acid; Amperometric sensor; Yb2O3.CuO@rGO; Vitamin C; Human blood serum

Online: 26 April 2023 (03:32:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0885.v1

Development of Sensitive Electrochemical Sensor Based on Chi-Tosan/MWCNTs-AuPtPd Nanocomposites for Detection of Bisphenol A

En Han, Yingying Pan, Lei Li, Yuan Liu, Yuan Gu, Jianrong Cai

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Nanozyme; Metallic nanocomposite; Bisphenol A; Electrochemical sensors

Online: 25 April 2023 (04:23:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0507.v1

Flexible Humidity Sensor Based on Au Nanoparti-Cles/Organosilica-Containing Polyelectrolyte Composite

Pi-Guey Su, Chih-Chang Hsu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Flexible humidity sensor; organosilica; Au NPs; composite; water-resistance

Online: 18 April 2023 (08:28:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0459.v1

A Novel Bioanalytical HPLC-MS/MS Method for Deucravacitinib Determination in Human Plasma

Pottabattula Mahesh, M. Akiful Haque, Baher I. Salman, Tarek S. Belal, Adel Ehab Ibrahim, Sami El Deeb

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Deucravacitinib; HPLC-MS/MS; Psoriasis; Human plasma

Online: 18 April 2023 (02:51:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202303.0374.v1

A Screening Approach to Assess the Impact of Various Commercial Sources of Crude Marine λ-Carrageenan on the Production of Oligosaccharides with Anti-Heparanase and Anti-Migratory Activities

Chanez Manseur, Hugo Groult, Manon Porta, Pierre-Edouard Bodet, Nicolas Bridiau, Rachida Mersni-Achour, Raphaëlle Petit, Samir Ali-Moussa, Benjamin Musnier, Didier Le Cerf, Tony Varacavoudin, Oualid Haddad, Angela Sutton, Jean-Marie Piot, Thierry Maugard, Ingrid Fruitier-Arnaudin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: marine algae; lambda-carrageenan; oligosaccharides; heparanase; migration; anti-cancer agents

Online: 21 March 2023 (09:16:48 CET)

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Oligosaccharides derived from λ-carrageenan (λ-COs) are gaining interest in the cancer field. They have been recently reported to regulate heparanase (HPSE) activity, a protumor enzyme involved in cancer cell migration and invasion, making them very promising molecules for new therapeutic applications. However, one of the specific features of commercial λ-carrageenan (λ-CARs) is that they are in fact heterogeneous mixtures of different CARs families, and are named according to the thickening purpose of the product which does not reflect the real com-position. Consequently, this can limit their use in a clinical grade. To address this issue, six commercial λ-CARs were compared for which differences in their physiochemical properties were shown. Then, a H2O2-assissed radical depolymerization was applied to each commercial source and the number and weight averaged molar masses (Mn and Mw) and sulfation degree (DS) of the λ-COs produced over time were determined. By adjusting the depolymerization time for each product, almost comparable λ-CO formulations could be obtained in term of molar masses and DS, that ranged within previously reported values suitable for anti-tumor proper-ties. However, when the anti-HPSE activity of these new λ-COs was screened, small changes that could not be attributed only to their small length or DS changes between them were found, suggesting a role of other features such as differences in the initial mixture composition. Further structural MS and NMR analysis revealed indeed qualitative and semi-quantitative differences between the molecular species, especially in the proportion of the anti-HPSE λ-type, other CARs types and adjuvants, but also showed that H2O2-based hydrolysis induced sugar degradation. Finally, when the effects of λ-COs were assessed in an in vitro migration cell-based model, they seemed more related to the proportion of other CAR types in the formulation than to their λ-type-dependent anti-HPSE activity.

Preprint ARTICLE | doi:10.20944/preprints202302.0339.v1

Efficient Extraction and Purification of Isofraxidin from Acanthopanax Senticosus by DES

Changhai Sun, Jinghua Hou, Shiyuan Sun, Yu Zhang, Xinran Zhang, Liting Mu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Acanthopanax senticosus; Deep eutectic solvents; Isofraxidin; Extraction

Online: 20 February 2023 (09:59:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0138.v1

Phage vs Phage: Direct Selections of Sandwich Binding Pairs

Emily C Sanders, Alicia M Santos, Eugene K Nguyen, Aidan A Gelston, Sudipta Majumdar, Gregory A Weiss

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: phage display; virus selections; sandwich binding; diagnostic assays; non-covalent binding

Online: 8 February 2023 (04:42:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0496.v1

Electrochemical Study of Bismuth Heavy Metals Using the Cyclic Voltammetry Method in Anti-Protozoal

ahmad alkhawaldeh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Heavy metal; Differential pulse ‎ voltammograms; Cyclic Voltammetry; Bismuth; Nanoparticle

Online: 27 January 2023 (06:51:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0495.v1

Technology Patterns in Nanochemistry Based on GII Indicator

ahmad alkhawaldeh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Global Innovation Index; Nanochemistry; Development; GII; and Technology patterns

Online: 27 January 2023 (06:48:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0451.v1

UV-Spectrophotometric Determination of the Active Pharmaceutical Ingredients Meloxicam and Nimesulide in Cleaning Validation Samples With Sodium Carbonate

Pavel Anatolyevich Nikolaychuk

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: meloxicam; nimesulide; UV-spectrophotometric determination; cleaning validation samples

Online: 25 January 2023 (09:41:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0542.v2

Cyclic Voltammogram Analysis of the Environmental Aspects of the Use of Ferrocenyl Carbinols

ahmad alkhawaldeh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Cyclic voltammograms; Chronoamperometric; Cyclic ketones structure; Environment ecological aspects ferrocene; Ecological aspects

Online: 25 January 2023 (04:01:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0441.v1

Cyclic Voltammogram Analysis of the 3,3´- (1,4-Phenylene) Perchlorates

ahmad alkhawaldeh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Cyclic voltammograms; Chronoamperometric; radical; electron-withdrawing substituent; electrode potential

Online: 25 January 2023 (03:54:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0203.v1

Pyrolysis of Waste Biomass – Technical and Process Achievements, and Future Development – A Review

Bartłomiej Igliński, Wojciech Kujawski, Urszula Kiełkowska

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: pyrolysis; pyrolysis reactors; bio-waste; biofuels; biochar; pyrolytic gas

Online: 12 January 2023 (02:11:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0102.v2

Producing Oxygen on the Moon and Mars for the Future Colonies by Using the Available Chemical Resources

Danial Karami

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Oxygen generator; Carbon dioxide; Sabatier process; Mars; Moon

Online: 9 January 2023 (08:16:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0434.v1

Evaluation of Terbutaline Adsorption from Aqueous Medium by Mechanically Generated [Cu (INA)2]-MOF Metal-Organic Framework and its Modified Magnetic Composite ([Cu (INA)2]-MOF@Fe3O4)

Usman Armaya’u, Marinah Mohd Ariffin, Saw Hong Loh, Wan Mohd Afiq Wan Mohd Khalik, Hanis Mohd Yusoff

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Adsorption; β-agonists; Magnetic-composite; Metal-Organic Frameworks; Pollutant; Removal; Terbutaline

Online: 23 December 2022 (01:51:10 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0271.v1

Electrochemical (Bio)Sensing Devices for Human Microbiome Related Biomarkers

Esther Sánchez-Tirado, Lourdes Agüí, Araceli González-Cortés, Susana Campuzano, Paloma Yáñez-Sedeño, José M Pingarrón

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Electrochemical biosensors; electrochemical sensors; microbiome; biomarkers

Online: 15 December 2022 (06:52:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0100.v1

Impact of Fresh and Fermented Olive Solid Waste and Cow Manure in Wheat Content of Fertility Elements (Nitrogen, Phosphorus and Potassium) and on Its Productivity

Abd Al Karim Jaafar, Akram Al Balkhi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: olive solid waste; cow manure; phosphorus; potassium; cation exchange capacity

Online: 6 December 2022 (10:06:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0094.v1

Gut Microbial Perturbation and Host Response Induces Redox Pathway Upregulation along the Gut-liver Axis during Giardiasis in C57BL/6J Mouse Model

Avinash V Karpe, Melanie L Hutton, Steven J Mileto, Meagan L James, Chris Evans, Amol B Ghodke, Rohan M Shah, Suzanne S Metcalfe, Jian-Wei Liu, Tom Walsh, Dena Lyras, Enzo A Palombo, David J Beale

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: host-parasite interactions; systems biology; giardiasis; gut-liver axis; integrated multiomics; metabolic pathways

Online: 6 December 2022 (07:39:57 CET)

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Apicomplexan infections, such as giardiasis and cryptosporidiosis, negatively impact a considerable proportion of human and commercial livestock populations. Despite this, the molecular mecha-nisms of disease, particularly the effect on the body beyond the gastrointestinal tract, are still poorly understood. To highlight host-parasite-microbiome biochemical interactions, we utilised integrated metabolomics-16S rRNA genomics and metabolomics-proteomics approaches in a C57BL/6J mouse model of giardiasis and compared these to Cryptosporidium and uropathogenic Escherichia coli (UPEC) infections. Comprehensive samples (faeces, blood, liver, and luminal contents from duo-denum, jejunum, ileum, caecum and colon) were collected 10 days post infection and subjected to proteome and metabolome analysis by liquid and gas chromatographic mass-spectrometry, re-spectively. Microbial populations in faeces and luminal washes were examined using 16S rRNA metagenomics. Proteome-metabolome analyses indicated that 12 and 16 key pathways were sig-nificantly altered in the gut and liver, respectively, during giardiasis with respect to other infections. Energy pathways including glycolysis and supporting pathways of glyoxylate and dicarboxylate metabolism, and redox pathway of glutathione metabolism, were upregulated in small intestinal luminal contents and the liver during giardiasis. Metabolomics-16S rRNA genetics integration in-dicated that populations of three bacterial families –Autopobiaceae (Up), Desulfovibrionaceae (Up) and Akkermanasiaceae (Down) – were most significantly affected across the gut during giardiasis, causing upregulated glycolysis and short-chained fatty acid (SCFA) metabolism. In particular, the perturbed Akkermanasiaceae population seemed to cause oxidative stress responses along the gut-liver axis. Overall, the systems biology approach applied in this study highlighted that the effects of host-parasite-microbiome biochemical interactions extended beyond the gut ecosystem to the gut-liver axis. These findings form the first steps in a comprehensive comparison to ascertain the major molecular and biochemical contributors of host-parasite interactions and contribute towards the development of biomarker discovery and precision health solutions for apicomplexan infections.

Preprint ARTICLE | doi:10.20944/preprints202212.0009.v1

A Novel Fluorescent Sensor Based on Aptamer and Qpcr for Determination of Glyphosate in Tap Water

Yong Shao, Run Tian, Jiaqi Duan, Miao Wang, Jing Cao, Zhen Cao, Guangyue Li, Fen Jin, Yongxin She, A. M. El-Aty

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Glyphosate; Aptamer; qPCR; SYBR Green I; sensor

Online: 1 December 2022 (04:00:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0460.v1

A Procedure for Estimating Fundamental Variability

Steffen Uhlig, Bertrand Colson, Petra Gowik

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Fundamental variability; homogeneity; variance; method validation; proficiency testing; measurement uncertainty

Online: 24 November 2022 (14:33:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0072.v1

Qualitative and Quantitative Evaluation of Rosavin, Salidroside, and p-tyrosol in Artic Root Products via TLC-screening, HPLC-DAD, and NMR Spectroscopy

Hanna Nikolaichuk, Marek Studziński, Marek Stankevič, Irena Maria Choma

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: TLC-screening; HPLC-DAD; NMR; arctic root

Online: 3 November 2022 (07:47:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202209.0389.v1

Bioethanol Production from Sequential Acidic-Alkaline Pretreated Sorghum Straw Hydrolysate and Investigation of the Effects of Fermentation Parameters using Response Surface Methodology

Abnet Mengesha Dube, Fseha Gebremichael Gebriheta

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Yield; Fermentation; Sequential Pretreatment; Sorghum Straw

Online: 26 September 2022 (09:11:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202209.0073.v1

Analytical Methods for Oxalate Quantification: The Ubiquitous Organic Anion

Bryan Misiewicz, Adam L. VanWert

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: oxalate; oxalic acid

Online: 6 September 2022 (02:43:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0373.v1

Detection and Verification of a Key Intermediate in an Enantioselective Peptide Catalyzed Acylation Reaction

Matthias Brauser, Tim Heymann, Christina Marie Thiele

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: acylation; imidazolium ion; mass spectrometry; NMR spectroscopy; organocatalysis

Online: 22 August 2022 (04:10:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0097.v1

Acoustic Emission Monitoring of Atmospheric Corrosion on Aluminum Aircraft Structures at Varying Relative Humidity

Thomas Erlinger, Christoph Kralovec, Martin Schagerl

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: acoustic emission; atmospheric corrosion; aluminum; aircraft structure; pitting corrosion; hydrogen bubbles; structural health monitoring

Online: 4 August 2022 (03:55:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0355.v1

Thin-Layer Chromatography (TLC) in Screening of Botanicals – its Versatile Potential and Selected Applications

Teresa Kowalska, Mieczysław Sajewicz

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: TLC screening of plants; TLC screening of psychoactive plants; TLC-direct bioautography; effect directed detection; chemotaxonomy of plants; quality control of medicinal plants; quality control of alimentary products; quality control of cosmetic products

Online: 25 July 2022 (07:50:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0055.v1

Defanging Chloroform – Mitigation of Deuterated Chloroform Decomposition to Stabilise Susceptible NMR Samples

Jan Teipel, Vera Gottstein, Eva Hölzle, Katja Kaltenbach, Dirk W. Lachenmeier, Thomas Kuballa

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: NMR; chemometrics; chloroform; phosgene; hydrochloric acid; sample degradation; pH-shift; protonation

Online: 5 July 2022 (03:53:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0126.v1

Development, Validation for Determination of Verteporfin by HPLC-DAD and Application to Real samples

Ahmet Ozgun DOGRAMACIOGLU, Cemile ÖZCAN

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: HPLC-DAD-UV; Verteporfin; ICH Q2 R; Validation

Online: 8 June 2022 (11:03:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0082.v1

Studies on the Effects of Process Conditions on Separation of B1, B2 and B3 Vitamin Mixture Using HILIC and RPLC Chromatography

Marcin Chutkowski, Piotr Ziobrowski, Mateusz Przywara, Justyna Kamińska, Wojciech Zapała

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: HILIC chromatography; RPLC chromatography; B1 vitamin; B2 vitamin; B3 vitamin

Online: 6 June 2022 (10:01:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0040.v1

Advanced Microsamples: Current Applications and Considerations for Mass Spectrometry-Based Metabolic Phenotyping Pipelines

Jayden Lee Roberts, Luke Whiley, Nicola Gray, Melvin Gay, Nathan G. Lawler

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Microsampling; sample miniaturisation; dried blood spot (DBS); dried plasma spot (DPS); dried serum spot (DSS); metabolic phenotyping; gas chromatography-mass spectrometry (GC-MS); liquid chromatog-raphy-mass spectrometry (LC-MS)

Online: 3 June 2022 (09:53:13 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202112.0420.v3

Essential Terminology and Considerations for Validation of Non-targeted Methods

Kapil Nichani, Steffen Uhlig, Manfred Stoyke, Sabine Kemmlein, Franz Ulberth, Ilka Haase, Maik Döring, Stephan G. Walch, Petra Gowik

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Non-targeted methods; method validation; food fraud; food authenticity; mass spectrometry; spectroscopy; NGS; NMR

Online: 23 May 2022 (11:10:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0034.v1

Rapid and Non-Destructive Analysis of Corky Off-Flavors in Natural Cork Stoppers by A Wireless and Portable Electronic Nose

José Pedro Santos, Isabel Sayago, Jose Luis Sanjurjo, María Soledad Perez-Coello, Maria Consuelo Díaz-Maroto

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Natural cork stoppers; Corky off-flavors; Electronic nose; Machine learning algorithms; Artificial neural networks

Online: 5 May 2022 (10:45:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0307.v1

Response Surface Optimisation of Polydimethylsiloxane (PDMS) on Borosilicate Glass and Stainless-Steel (SS316) to Increase Hydrophobicity

Saiful Irwan Zubairi, Nadiah Ramlan, Yusof Maskat

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Optimisation; Surface Modification; Contact Angle; PDMS; Stainless-Steel; Borosilicate Glass

Online: 23 March 2022 (04:25:16 CET)

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Particle deposition on the surface of the drying chamber poses the main drawback in the spray drying process, which reduces the product recovery and affects the quality of the product. In view of this, the potential application of chemical surface modification to produce a hydrophobic surface that reduces the powder adhesion (biofouling) on the wall of the drying chamber was investigated in this study. The hydrophobic Polydimethylsiloxane (PDMS) solution was used in the vertical dipping method at room temperature to determine the optimum coating parameters on borosilicate glass and stainless-steel substrates, which were used to mimick the wall surface of the drying chamber, to achieve highly hydrophobic surfaces. A single-factor experiment was used to define the range of the PDMS concentration and treatment duration using the Response Surface Methodology (RSM). The Central Composite Rotatable Design (CCRD) was used to study the effects of the concentration of the PDMS solution (X1, %) and the treatment duration (X2, hr) on the contact angle of the substrate (°), which reflected the hydrophobicity of the surface. A three-dimensional (3D) response surface was constructed to examine the influence of the PDMS concentration and treatment duration on the contact angle readings, which serve as an indicator of the surface's hydrophobic characteristic. Based on the optimisation study, the PDMS coating for the borosilicate glass achieved an optimum contact angle of 99.33° through the combination PDMS concentration: X1 = 1% (w/v) and treatment time X2 = 4.94 hr, while the PDMS coating for the stainless-steel substrate achieved an optimum contact angle of 98.31° with PDMS concentration: X1 = 1% (w/v) and treatment time X2 = 1 hr. Additionally, the infrared spectra identified several new peaks that appeared on the PDMS-treated surfaces, which represented the presence of Si-O-Si, Si-CH3, CH2, and CH3 functional groups for the substrates coated with PDMS. Furthermore, the surface morphology analysis using the Field Emission Scanning Electron Microscopy (FESEM) showed the presence of significant roughness and uniform nanostructure on the surface of PDMS-treated substrates, which indicated the reduction of wettability and the potential effect on unwanted biofouling on the spray drying chamber.

Preprint ARTICLE | doi:10.20944/preprints202203.0292.v1

Simultaneous Determination of Paracetamol, Ibuprofen, and Caffeine in Tablets by Molecular Absorption Spectroscopy Combined with Classical Least Square Method

Binh Thuc Tran, Tuyen Ngoc Tran, Ai My Thi Tran, Giang Chau Dang Nguyen, Quynh Trang Thi Nguyen

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: paracetamol; ibuprofen; caffeine; classical least-square; simultaneous; spectroscopy

Online: 22 March 2022 (03:26:27 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202203.0152.v1

Coated Blade Spray-Mass Spectrometry as a New Approach for the Rapid Characterization of Brain Tumors

Joanna Bogusiewicz, Magdalena Gaca-Tabaszewska, Dominik Olszówka, Karol Jaroch, Jacek Furtak, Marek Harat, Janusz Pawliszyn, Barbara Bojko

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: SPME; CBS-MS; brain tumors; lipidomics

Online: 10 March 2022 (14:16:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0012.v1

Monitoring Farmed Fish Welfare by Measurement of Cortisol as Stress Marker in Fish Feces by Liquid Chromatography Coupled with Tandem Mass Spectrometry

Vanessa Andrea Meling, Kjetil Berge, David Lausten Knudsen, Per Ola Rønning, Cato Brede

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: aquaculture; fish; salmon; feces; deconjugation; hydrolysis; extraction; chromatography; mass spectrometry; LC-MS/MS

Online: 1 March 2022 (09:36:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0300.v1

Rapid on-site Detection of Illicit Drugs in Smuggled Samples with a Portable Electrochemical Device

Marc Parrilla, Amorn Slosse, Robin Van Echelpoel, Noelia Felipe Montiel, Amelia R Langley, Filip Van Durme, Karolien De Wael

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Electrochemical sensors; square-wave voltammetry; screen-printed electrodes; electrochemical profiling; illicit drugs; forensic analysis; Raman spectrometer; on-site detection; FTIR spectrometer

Online: 24 February 2022 (04:00:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0403.v2

Portable FRET-Based Biosensor Device for On-Site Lead Detections

Wei-Qun Lai, Yu-Fen Chang, Fang-Ning Chou, De-Ming Yang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: lead biosensors; FRET; portable Pb sensor; smartphone-based device; Met-lead; tap water lead; groundwater lead

Online: 23 February 2022 (10:53:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0118.v1

Cognate DNA Recognition by Engrailed Homeodomain Involves a Conformational Change Controlled via an Electrostatic-Spring-Loaded Latch

Nicola D'Amelio, Benjamin Tanielian, Mourad Sadqi, Pilar Lopez-Navajas, Victor Victor Muñoz

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: protein-DNA interactions; DNA recognition; transcription factors; DNA binding domains; con-formational change; nuclear magnetic resonance; circular dichroism; control of gene expression; homeodomains.

Online: 8 February 2022 (14:53:06 CET)

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Transcription factors must scan genomic DNA, recognize the cognate sequence of their control element(s), and bind tightly to them. The DNA recognition process is primarily carried out by their DNA binding domains (DBD), which interact with the cognate site with high affinity and more weakly with any other DNA sequence. DBDs are generally thought to bind to their cognate DNA without changing conformation (lock-and-key). Here we used nuclear magnetic resonance and circular dichroism to investigate the interplay between DNA recognition and DBD conformation in the Engrailed homeodomain (EnHD), as model case for the homeodomain family of eukaryotic DBDs. We found that the conformational ensemble of EnHD is rather flexible and becomes more structured as ionic strength increases following a Debye-Hückel’s dependence. Our analysis indicates that EnHD’s response to ionic strength is mediated by a built-in electrostatic spring-loaded latch that operates as conformational transducer. We also found that, at moderate ionic strengths, EnHD changes conformation upon binding to cognate DNA. This change is of larger amplitude and somewhat orthogonal to the response to ionic strength. As a consequence, very high ionic strengths (e.g. 700 mM) block the electrostatic-spring-loaded latch and binding to cognate DNA becomes lock-and-key. However, the interplay between EnHD conformation and cognate DNA binding is robust across a range of ionic strengths (i.e. 45 to 300 mM) that covers the most physiologically-relevant conditions. Therefore, our results demonstrate the presence of a mechanism for the conformational control of cognate DNA recognition on a eukaryotic DBD. This mechanism can function as a signal transducer that immediately locks the DBD in place upon encountering the cognate site during active DNA scanning. The electrostatic-spring-loaded latch of EnHD can also enable the fine control of DNA recognition in response to local/temporal changes in ionic strength induced by variate physiological processes.

Preprint ARTICLE | doi:10.20944/preprints202201.0403.v1

Portable FRET-Based Biosensor Device for On-Site Lead Detections

Wei-Qun Lai, Yu-Fen Chang, Fang-Ning Chou, De-Ming Yang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: lead biosensors; FRET; portable Pb sensor; smartphone-based device; Met-lead; tap water lead; groundwater lead

Online: 26 January 2022 (14:49:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0092.v1

Rapid Simultaneous Determination of 11 Synthetic Cannabinoids in Urine by Liquid Chromatography-Triple Quadrupole Mass Spectrometry

Jianbing Wu, Fang Zhang, Xing Ke, Wei Jia, xuzhi wan, Lange Zhang, Laizhao Wang, Yilei Fan

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Synthetic cannabinoids; LC-MS/MS; Simultaneous determination; Matrix effect; Urine

Online: 6 January 2022 (14:10:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0493.v1

Direct in vivo Analysis of CBD- and THC-Acid Type Cannabinoids and Classification of Cannabis Cultivars by SpiderMass

Nina Ogrinc, Serge Schneider, Adèle Bourmaud, Michel Salzet, Isabelle Fournier

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: water-assisted laser desorption/ionization; SpiderMass; cannabinoids; mass spectrometry; plants; in vivo

Online: 30 December 2021 (19:02:18 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202112.0420.v2

Essential Terminology and Considerations for Validation of Non-targeted Methods

Kapil Nichani, Steffen Uhlig, Manfred Stoyke, Sabine Kemmlein, Franz Ulberth, Ilka Haase, Maik Döring, Stephan G Walch, Petra Gowik

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Non-targeted methods; method validation; food fraud; food authenticity; mass spectrometry; spectroscopy; NGS; NMR

Online: 28 December 2021 (10:28:50 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202112.0420.v1

Towards a Mathematical Framework for Method Validation and Performance Characteristics of Non-targeted Methods for Food Authenticity

Kapil Nichani, Steffen Uhlig, Manfred Stoyke, Sabine Kemmlein, Franz Ulberth, Ilka Haase, Maik Döring, Stephan G Walch, Petra Gowik

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Non-targeted methods; method validation; food fraud; food authenticity; mass spectrometry; spectroscopy; NGS; NMR

Online: 27 December 2021 (10:31:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0259.v1

Multifunctional Eco-Friendly Synthesis of ZnO Nanoparticles in Biomedical Applications

Amal Mohamed Al-Mohaimeed, Wedad Altuhami Al-Onazi, Maha Farouk El-Tohamy

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Oat extract; Zinc oxide nanoparticles; Green synthesis; Antibacterial; Antioxidant; Pharmaceutical analysis.

Online: 15 December 2021 (15:17:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0229.v1

Assessment of K-Struvite Precipitation as a Means of Nutrient Recovery From Source Separated Human Urine

Işık Kabdaşlı, Sezen Kuşçuoğlu, Olcay Tünay, Alessio Siciliano

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: human urine; K-struvite precipitation; nutrient recovery; operation parameters; solid phases

Online: 14 December 2021 (11:46:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0046.v1

Rapid, Simple and Inexpensive Fabrication of Paper-based Analytical Devices by Parafilm® Hot Pressing

Sursak Kasetsirikul, Kimberley Clack, Muhammad J.A. Shiddiky, Nam-Trung Nguyen

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Paperfluidics; Parafilm; Paper-based Analytical Devices

Online: 3 December 2021 (09:58:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0546.v1

Review on Chemical Graph Theory and Its Application in Computer-Assisted Structure Elucidation

Mehmet Aziz Yirik, Kumsal Ecem Colpan, Saskia Schmidt, Maria Sorokina, Christoph Steinbeck

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chemical graph theory; computational chemistry; CASE; computer-assisted structure elucidation

Online: 29 November 2021 (15:35:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0542.v1

Cyclic Voltammogram Analysis of the Environmental Aspects of the Use of Ferrocenyl Carbinols

ahmad alkhawaldeh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Cyclic voltammograms; Chronoamperometric; Cyclic ketones structure; Environment ecological aspects ferrocene; Ecological aspects

Online: 29 November 2021 (14:55:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0494.v1

On the Potential of a Poly(Vinylidenefluoride-Co-hexafluoropropylene) Polymer Inclusion Membrane Containing Aliquat® 336 and Dibutyl Phthalate for V(V) Extraction from Sulfate Solutions

Salar Bahrami, Leila Dolatyari, Hassan Shayani-Jam, Mohammad Reza Yaftian, Spas D. Kolev

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Polymer inclusion membrane (PIM); Poly(vinylidenefluoride-co-hexafluoropropylene); Vanadium(V); Extraction; Aliquat® 336

Online: 26 November 2021 (09:03:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0430.v1

Two Compounds of 1-((4-Bromothiophen-2-Yl)Methylene)-2-(Perfluorophenyl)Hydrazine, and 1-((4-Bromo-5-Methylthiophen-2-Yl)Methylene)-2-(Perfluorophenyl)Hydrazine and They Crystal, Molecular and Electronic Properties

Július Sivý, Dušan Bortňák, Daniel Végh, Erik Rakovský

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Ab initio DFT/B3LYP/6-311G/Auto calculation; hydrazine; Hirshfeld surface; hydrogen interactions; single-crystal X-ray study

Online: 23 November 2021 (15:03:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0251.v1

Hydrogen Delocalization in an Asymmetric Biomolecule: The Curious Case of alpha-Fenchol

Robert Medel, Johann R. Springborn, Deborah L. Crittenden, Martin A. Suhm

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: delocalization; tunneling; terpene; alcohol; vibrational spectroscopy; supersonic jet expansion; structural determination

Online: 15 November 2021 (11:12:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0369.v1

Determination of Avermectins Residues in Soybean, Bean and Maize Using a QuEChERS-based Method and Ultra-high-performance Liquid Chromatography Coupled to Tandem Mass Spectrometry

Fernanda Uczay, Nelson M.G. Bandeira, Luana Floriano, Osmar D. Prestes, Martha B. Adaime, Renato Zanella

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Macrocyclic lactones; agricultural crops; food; sample preparation; UHPLC-MS/MS

Online: 25 October 2021 (15:50:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0036.v2

A Primer on Harnessing Non-enzymatic Posttranslational Modifications for Drug Design

Marcus Long, Phillippe Ly, Yimon Aye

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Electrophile; Drug Design; Covalent Drug; Chemical Biology

Online: 19 October 2021 (10:28:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0044.v1

Synthesis of Hydrogel Films Based on PVA, PVP, Starch and Keratin Extracted From Chicken Feathers Wastes for the Potential Biomedical Applications

Mohamed Saad Bala Husain, Basma Yahya Al-Ashwal, Arun Gupta, Swati Sharma, Venugopal Jayarama Reddy, Husam Eldin Elhag Abugabr Elhag, Triveni Soubam

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Hydrogel; Keratin; Chicken feather waste

Online: 4 October 2021 (10:49:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0035.v1

Distinguishing Between Isobaric Ions Using Microdroplet Hydrogen-Deuterium Exchange Mass Spectrometry

Xiaowei Song, Jia Li, Mohammad Mofidfar, Richard N. Zare

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: hydrogen-deuterium exchange; mass spectrometry; isobaric ions; ambient ionization; metabolic profiling

Online: 4 October 2021 (09:21:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0527.v1

Hyaluronate-Thiol Passivation Enhances Gold Nanoparticle Peritumoral Distribution When Administered Intratumorally in Lung Cancer

Rossana Terracciano, Yareli Carcamo-Bahena, E. Brian Butler, Danilo Demarchi, Alessandro Grattoni, Carly S. Filgueira

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Gold Nanoparticles; Hyaluronate-Thiol; In vitro; In vivo; Peritumoral; Cancer; Cytotoxicity; ICP-OES; Biodistribution

Online: 1 October 2021 (11:12:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0478.v1

Mushroom’s Evaluation Based on FT-IR Fingerprint and Chemometrics

Ioana Feher, Cornelia Veronica Floare-Avram, Florina-Dorina Covaciu, Olivian Marincas, Romulus Puscas, Dana Alina Magdas, Costel Sarbu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: mushrooms; FT-IR; chemometric; machine learning

Online: 28 September 2021 (21:36:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0427.v1

Quality of Alcohol Based Hand Sanitizers Marketed in the Nairobi Metropolis

Kennedy Abuga, Nasser Nyamweya, Obed King’ondu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Hand sanitizer; COVID-19; alcohol; methanol substitution; gas chromatography; substandard products; falsified products; post-market surveillance

Online: 24 September 2021 (12:25:25 CEST)

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Working Paper ARTICLE

Utilizing a Rapid Multi-Plug Filtration Cleanup Method Determination of 72 Pesticides in Grape Wines by Gas Chromatography Tandem Mass Spectrometry

shaowen Liu, Aijuan Bai, Le Song, Nan Zou, Yongtao Han, Li Zhou, Chuanshan Yu, Canping Pan

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Pesticide residue /GC- MS/MS/m-PFC/Wine

Online: 3 September 2021 (17:16:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0056.v1

A Microfluidic Aptamer-Based Sensor for Detection of Mercury (II) and Lead (II) Ions in Water

Wei-Hao Huang, Ruo-Yin Wu, Ko-Li Yeh, Van-Phung Mai, Ruey-Jen Yang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Aptamer; Fluorescence Resonance Energy Transfer; Heavy Metal Ions; Graphene Oxide; Microfluidic Device; Sensor.

Online: 3 September 2021 (10:29:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0048.v1

UHPLC-Orbitrap-HRMS Identification of 51 Oleraceins (Cyclo-Dopa Amides) in Portulaca oleracea L. Cluster Analysis and MS2 Filtering by Mass Difference

Yulian Voynikov, Paraskev Nedialkov, Reneta Gevrenova, Dimitrina Zheleva-Dimitrova, Vessela Balabanova, Ivan Dimitrov

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: orbitrap; purslane; oleracein; diagnostic ion; diagnostic difference; clustering methods

Online: 2 September 2021 (16:01:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0383.v1

Carotenoids in Bacteria: Biosynthesis, Extraction, Characterization and Applications

Gerson-Dirceu López, Gerardo Álvarez-Rivera, Chiara Carazzone, Elena Ibañez, Chad Leidy, Alejandro Cifuentes

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Bacterial carotenoids; Cell disruption; HPLC separation; MS analysis; Food and textile applications

Online: 18 August 2021 (14:09:35 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202108.0196.v1

Complete Assignment of the ¹H and ¹³C NMR Spectra of Carthamin Potassium Salt Isolated from Carthamus Tinctorius L.

Maiko Sasaki, Keiko Takahashi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: carthamin-3’potassium salt, green metallic luster, fermented safflower petal tablet

Online: 9 August 2021 (12:49:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0133.v1

Organic Functionalized Carbon Nanostructures for Solar Energy Conversion

Luca Lazzarin, Mariacecilia Pasini, Enzo Menna

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Carbon nanotubes, graphene, reduced graphene oxide, organic functionalization, dye, organic photovoltaics, dye sensitized solar cells, perovskite solar cells, photocatalytic hydrogen evolution

Online: 5 August 2021 (10:07:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0132.v1

Effective Desalination of Acid Mine Drainage Using an Advanced Oxidation Process

Alexis Munyengabe, Caliphs Zvinowanda, John N. Zvimba, James Ramontja

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Sodium ferrate (VI); Oxidation and Coagulation; Neutralization of AMD; Metal removal

Online: 5 August 2021 (09:44:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0102.v1

Producing the most Significant Vital Gas for Humanity's Survival during Colonization of Other Planets by Using the Available Resources

Danial Karami

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Oxygen generator; Carbon dioxide; Sabatier process; Astronauts; ISS

Online: 4 August 2021 (09:16:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0100.v1

A Dansyl-Modified Sphingosine Kinase Inhibitor Dpf-543 Enhanced de Novo Ceramide Generation

Maftuna Shamshiddinova, Shokhid Gulyamov, Hee Jung Kim, Seo Hyeon Jung, Dong Jae Baek, Yong-Moon Lee

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: PF-543; ceramide; SPHK; SPT; ceramide synthases; sphingolipid; metabolism; LC-MS/MS.

Online: 4 August 2021 (08:32:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0073.v1

How Ultrasonic-Assisted CO₂ EOR to Unlock Oils From Unconventional Reservoirs?

Hengli Wang, Leng Tian, Kaiqiang Zhang, Zongke Liu, Can Huang, Lili Jiang, Xiaolong Chai

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Ultrasonic; Carbon dioxide; Enhanced oil recovery; Unconventional reservoirs

Online: 3 August 2021 (11:25:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0014.v1

The Aerob and Anaerob Performance Beta-Alanine Supplement and Ergogenic Aid Using to the Power Output Variables in Cyclists: A Cohort Studies Random Model Effect

Yeliz Kahraman

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Beta-alanine; supplementation; nutrition,; aerob and anaerob performance

Online: 2 August 2021 (10:18:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0668.v1

Effect of Storage Conditions on the Quality of Arbequina Extra Virgin Olive Oil and the Impact on the Composition of Flavor-related Compounds (Phenols and Volatiles)

Leeanny Caipo, Ana Sandoval, Betsabet Sepúlveda, Edwar Fuentes, Rodrigo Valenzuela, Adam Metherel, Nalda Romero

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: olive oil; quality; storage conditions; phenols; volatile compounds; E-2-Nonenal

Online: 29 July 2021 (15:27:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0631.v1

Combining Pressurized Liquid Extraction and Enzymatic-Assisted Extraction to Obtain Bioactive Non-Extractable Polyphenols from Sweet Cherry (Prunus avium L.) Pomace

Gloria Domínguez-Rodríguez, María Concepción García, María Luisa Marina, Merichel Plaza

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: pressurized liquid extraction; enzyme-assisted extraction; non-extractable polyphenols; proanthocyanidins; sweet cherry pomace

Online: 28 July 2021 (12:23:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0521.v1

Cocaine Detection by a Laser-induced Immunofluorometric Biosensor

Martin Paul, Robert Tannenberg, Georg Tscheuschner, Marco Wilke, Michael G. Weller

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Online detection, security; biosensor; flow injection assay; monoclonal antibody; fluorescence microscope; lab-on-a-chip; microfluidic systems; antibody labeling; CMOS; diode laser; monolithic column; laser-induced fluorescence detector (LIF); low-cost; high-speed; non-competitive immunoassay; immunometric assay

Online: 22 July 2021 (14:13:46 CEST)

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Working Paper ARTICLE

Absolute Absorption Cross Section of the Ã←X ̃ Electronic Transition of the Ethyl Peroxy Radical and Rate Constant of its Cross Reaction with HO2

Cuihong Zhang, Mirna Shamas, Mohamed Assali, Xiaofeng Tang, Weijun Zhang, Laure Pillier, Coralie Schoemaecker, Christa Fittschen

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Peroxy radicals, near-infrared spectroscopy, Ã←X electronic transition, cavity ring down spectroscopy

Online: 21 July 2021 (16:19:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0462.v1

Halogens in Acetophenones Direct the Hydrogen Bond Docking Preference of Phenol via Stacking Interactions

Charlotte Zimmermann, Manuel Lange, Martin A. Suhm

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: London dispersion; ketone complexes; density functional theory; hydrogen bonds; molecular recognition; vibrational spectroscopy; gas phase; benchmark

Online: 20 July 2021 (16:06:47 CEST)

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Working Paper ARTICLE

The Effect of Cluster Size on the Intra-Cluster Ionic Polymerization Process

Estefania Rossich Molina, Tamar Stein

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: acetylene; polycyclic aromatic hydrocarbons; interstellar medium; molecular growth; benzene; Ab initio molecular dynamics; van der Waals clusters; ion-molecule reactions; astrochemistry

Online: 20 July 2021 (10:21:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0390.v1

Improvements in Gold Nanorod Biocompatibility with Sodium Dodecyl Sulfate Stabilization

Rossana Terracciano, Aobo Zhang, Mathieu L. Simeral, Danilo Demarchi, Jason H. Hafner, Carly S. Filgueira

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Gold Nanorods; Theranostics; In vitro; Cancer; Cytotoxicity; CTAB; SDS; microCT; ICP-OES

Online: 16 July 2021 (16:36:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0292.v2

Antibiotic Removal from Aquatic Environment with Activated Carbon Produced from the Pumpkin Seeds

İhsan Alacabey

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Activated carbon; adsorption; ciprofloxacin; pollutant; pumpkin seed; thermodynamics

Online: 14 July 2021 (14:12:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0327.v1

Modeling the Dual-function Effects of Hybrid-photopolymerization in Iodonium/Amine and Two Monomers System

Jui-Teng Lin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: polymerization kinetics; photoinitiator; monomer conversion profile; synergetic effects.

Online: 14 July 2021 (12:03:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0315.v1

Expanding the Myxochelin Natural Product Family by Nicotinic Acid Containing Congeners

Nicolas A. Frank, Márió Széles, Sergi H. Akone, Sari Rasheed, Stephan Hüttel, Simon Frewert, Mostafa M. Hamed, Jennifer Herrmann, Soeren M. M. Schuler, Anna K. H. Hirsch, Rolf Müller

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Myxobacteria; myxochelin; nicotinic acid; secondary metabolites; natural product discovery; precursor-directed biosynthesis; total synthesis

Online: 14 July 2021 (10:03:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0296.v1

Up-Dated the Critical Issues of Corneal Cross-Linking (Type-I and II): Safety Dose for Ultra-Thin Cornea, Role of Oxygen and Initiator Regeneration

Jui-Teng Lin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Corneal crosslinking; efficacy; kinetic modeling; oxygen; riboflavin; ultraviolet light; safety dose; minimum thickness.

Online: 13 July 2021 (11:19:16 CEST)

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Aims:To update analytic formulas for the overall efficacy of corneal collagen crosslinking (CXL) including both type-I and oxygen-mediated type-II mechanisms, the role of oxygen and the initiator regeneration. Study Design:modeling the kinetics of CXL in UV light and using riboflavin as the photosensitizer.Place and Duration of Study:New Taipei City, Taiwan, between June, 2021 and July, 2021.Methodology:Coupled kinetic equations are derived under the quasi-steady state condition for the 2-pathway mechanisms of CXL. For type-I CXL, the riboflavin (RF) triplet state [T] may interact directly with the stroma collagen substrate [A] to form radical (R) and regenerate initiator. For type-II process, [T] interacts with oxygen to form a singlet oxygen [¹O₂]. Both reactive radical (R) and [¹O₂], can relax to their ground state, or interact with the substrate [A]) for crosslinking. Based on a safety dose, the minimum corneal thickness formula is derived. Results:Our updated theory/modeling showed that oxygen plays a limited and transient role in the process, in consistent with that of Kamave [2]. In contrary, Kling et al [3] believed that type-II is the predominant mechanism, which however conflicting with the epi-on CXL results. For both type-I and type-II, a transient state conversion (crosslink) efficacy in an increasing function of light intensity (or dose), whereas, its steady state efficacy is a deceasing function of light intensity. RF depletion in type-I is compensated by the RF regeneration term (RGE) which is a decreasing function of oxygen. For the case of perfect regeneration case (or when oxygen=0), RF is a constant due to the catalytic cycle. Unlike the conventional Dresden rule of 400 um thickness, thin cornea CXL is still safe as far as the dose is under a threshold dose (E*), based on our minimum thickness formula (Z*). Our formula for thin cornea is also clinically shown by Hafez et al forultra thin (214 nm) CXL. Conclusion: For both type-I and type-II, a transient state conversion (crosslink) efficacy in an increasing function of light intensity (or dose), whereas, its steady state efficacy is a deceasing function of light intensity. Ultra thin cornea is still safe as far as it is under a threshold dose (E*), based on our minimum thickness formula.

Preprint ARTICLE | doi:10.20944/preprints202107.0292.v1

Antibiotic Removal from Aquatic Environment with Activated Carbon Produced from the Pumpkin Seeds

İhsan Alacabey

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Activated carbon; adsorption; ciprofloxacin; pollutant; pumpkin seed; thermodynamics

Online: 13 July 2021 (11:14:31 CEST)

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Chemistry and Materials Science