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Subject: Biology And Life Sciences, Other Keywords: system structure; organised complexity; organisation; models of organisation; whole-part graphs; synexions; organised sets; organisation interaction; in-formation

Online: 3 November 2016 (10:41:01 CET)

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Preprint ESSAY | doi:10.20944/preprints202401.1453.v3

Goodbye H-index, Welcome C-score

Valenti Rull

Subject: Biology And Life Sciences, Other Keywords: h-index; c-score; individual evaluation; citation scores; first authorship; multiauthorship; scientific misconduct

Online: 24 January 2024 (07:32:45 CET)

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Preprint REVIEW | doi:10.20944/preprints201705.0159.v1

Dental Wear: Attrition, Erosion and Abrasion—A Palaeo-Odontological Approach

Geoffrey H. Sperber

Subject: Biology And Life Sciences, Other Keywords: tooth wear; attrition; erosion; abrasion; palaeo-odontology

Online: 22 May 2017 (07:36:30 CEST)

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Working Paper ARTICLE

Bistability of Somatic Pattern Memories: Stochastic Outcomes in Bioelectric Circuits Underlying Regeneration

Giovanni Pezzulo, Joshua LaPalme, Fallon Durant, Michael Levin

Subject: Biology And Life Sciences, Other Keywords: regeneration; bioelectricity; planaria; bistability; memory; cognitive science

Online: 28 November 2019 (03:12:53 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0647.v1

Biological Organization Principles: Biogenesis, Cognition and Evolution of Living Systems

Carlos Maureira, Jose Garcia

Subject: Biology And Life Sciences, Other Keywords: Biological Organization Principles; Dynamical Systems; Bayesian Inference and Brian; FEP; Autopoiesis; Evolution; Cognition; Niche; KAM-dynamics Contents

Online: 28 August 2020 (15:08:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints201812.0352.v1

Harmful Algal Blooms (HABS) along Mexican Coasts

Magnolia Gricel Salcedo-Garduño, María del Refugio Castañeda-Chávez, Fabiola Lango-Reynoso, Itzel Galaviz-Villa

Subject: Biology And Life Sciences, Other Keywords: marine biotoxins; contaminated seafood; public health

Online: 29 December 2018 (02:31:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0266.v1

Extending the Explanatory Scope of Evolutionary Theory: The Origin of Historical Kinds in Biology and Culture

Gunter Wagner, Gary Tomlinson

Subject: Biology And Life Sciences, Other Keywords: historical individuals, extended evolutionary synthesis, evolutionary innovation, culture

Online: 24 April 2019 (11:20:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0039.v1

Benveniste’s Experiments Explained by a Non-Conventional Experimenter Effect

Francis Beauvais

Subject: Biology And Life Sciences, Other Keywords: systems biology; probabilistic modelling; experimenter effect; quantum-like correlations

Online: 6 March 2018 (03:35:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0132.v1

Body Temperature Responses during Phases of Work in Human Remains Detection Dogs Undergoing a Simulated Deployment

Janice Baker, Mallory DeChant, Eileen Jenkins, George Moore, Kathleen Kelsey, Erin Perry

Subject: Biology And Life Sciences, Other Keywords: working dogs; travel; thermal stress

Online: 8 March 2020 (04:40:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0419.v1

Facing the Harsh Reality of Access and Benefit Sharing (ABS) Legislation

Frank Michiels, Ulrich Feiter, Stéphanie Paquin-Jaloux, Diana Jungmann, Axel Braun, Mary Ann P. Sayoc, Ricard Armengol, Markus Wyss, Bruno David

Subject: Biology And Life Sciences, Other Keywords: Convention on Biological Diversity; Access and Benefit Sharing; Nagoya Protocol; industry perspective

Online: 23 November 2021 (10:46:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0084.v1

Biomass-Based Innovations in Demand Driven Research and Development Projects in Africa

Raymond Jatta, Nana Afranaa Kwapong, Bertrand Festus Nero, Oluwole Fatunbi

Subject: Biology And Life Sciences, Other Keywords: demand driven research; biomass; innovation; Ghana

Online: 5 July 2018 (08:09:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0433.v1

Association Between the General Practitioner Workforce Crisis and Premature Mortality in Hungary: Nationwide Evaluation of Health Insurance Data from 2006 to 2014

János Sándor, Anita Pálinkás, Ferenc Vincze, Valéria Sipos, Nóra Kovács, Tibor Jenei, Zsófia Falusi, László Pál, László Kőrösi, Magor Papp, Róza Ádány

Subject: Biology And Life Sciences, Other Keywords: primary health care; workforce crisis; general practitioner vacancy; aging of general practitioners; premature mortality

Online: 30 May 2018 (05:47:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0226.v2

The Non-Tragedy of the Non-Linear Commons

Marco Archetti, István Scheuring, Douglas Yu

Subject: Biology And Life Sciences, Other Keywords: positive assortment; public goods; collective action; common-pool resources; cooperation; game theory; group selection; kin selection; social dilemma

Online: 16 June 2020 (12:35:40 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202109.0132.v1

A need for Recalibration of the Discussions on Access and Benefit Sharing

Rodrigo Sara, Markus Wyss, René Custers, Anouk in 't Veld, Dominic Muyldermans

Subject: Biology And Life Sciences, Other Keywords: Access and Benefit Sharing (ABS); resource mobilization; Digital Sequence Information (DSI); Post-2020 Global Biodiversity Framework; biodiversity crisis

Online: 7 September 2021 (16:07:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.0461.v1

Ten Quick Tips for Accurate Reconstruction of Prokaryotic and Eukaryotic Genome-Scale Metabolic Models

Gabriela Canto-Encalada, Jenna Armstrong, Carlos Focil-Espinosa4, Ademikanra Adekunle-Fiyin, Ila Peeler, William R. Gebbie, Julio Nunez-Garcia, Alexis Saldivar, Diego Martinez, Cristal Zuniga

Subject: Biology And Life Sciences, Other Keywords: Genome-scale metabolic model reconstruction; manual curation; quick tips; systems biology

Online: 7 November 2023 (14:59:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0064.v1

Inchoative Discovery of Plausible (Un)explored Synergistic Combinatorial Biological Hypotheses for Static/Time Series Wnt Measurements via Ranking Search Engine : BioSearch Engine Design

Shriprakash Sinha

Subject: Biology And Life Sciences, Other Keywords: combinatorial search forest; sensitivity analysis; support vector ranking algorithm; unknown biological hypotheses; Wnt pathway; PORCN-WNT inhibitors; ETC-1922159; Sobol indices; Hilbert Schmidt independence criterion indices (HSIC); F-divergence (Fdiv); systems biology

Online: 5 December 2018 (07:52:17 CET)

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\textsc{Background} Often, in biology, we are faced with the problem of exploring relevant unknown biological hypotheses in the form of myriads of combination of factors that might be affecting the pathway under certain conditions. Currently, a major problem in biology is to cherry pick the combinations based on expert advice, literature survey or guesses for investigation. The search and wet lab testing of these combinations costs a lot in terms of time, investment and energy. In a recent development of the PORCN-WNT inhibitor ETC-1922159 for colorectal cancer, a list of down-regulated genes were recorded in a time buffer after the administration of the drug. The regulation of the genes were recorded individually but for a majority, it is still not known which higher ($\geq 2$) order combinations might be playing a greater role in the pathway. \textsc{Results} The pipeline provides a prioritised list of important $2^{nd}$ order combinations of a range of family of genes involved in the Wnt pathway. More specifically, it reveals the various unexplored FZD-WNT combinations that have been untested till now in the pathway. In relation to ETC-1922159 affected combinations, the down-regulation of LGR-RNF family after the drug treatment is evident in these rankings as it takes bottom priorities for LGR5-RNF43 combination. The LGR6-RNF43 takes higher ranking than LGR5-RNF43, indicating that it might not be playing a greater role as LGR5 during the Wnt enhancing signals. These rankings confirm the efficacy of the proposed search engine design. \textsc{Conclusion} A pipeline has been developed to prioritise an $n^{th}$ order combination of factors that affect a signaling pathway. It takes into account the sensitivity indices computed from variance based (SOBOL) and density-kernel based (HSIC) methods to estimate the influence of each factor or combination of factors. These are then fed as feature vectors into a powerful support vector ranking algorithm that produces a ranked list of the interactions/combinations.

Preprint ARTICLE | doi:10.20944/preprints201809.0044.v1

Efficiency of Using Smart-Mobile Phones in Accessing Agricultural Information by Smallholder Farmers in North Kordofan – Sudan

Mohammed Adam Abbas Hamad, Muneer Eltahir, Adam Elradi Mohamed Ali, Adam Muhana Hamdan, Amgad Ahmed Hamad Elsafi

Subject: Biology And Life Sciences, Other Keywords: Agricultural information, smart-mobile, stakeholder farmers, Sudan

Online: 3 September 2018 (15:12:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0226.v1

The Non-Tragedy of the Non-Linear Commons

Marco Archetti, István Scheuring, Douglas Yu

Subject: Biology And Life Sciences, Other Keywords: positive assortment; public goods; collective action; common-pool resources; cooperation; game theory; group selection; kin selection; social dilemma

Online: 15 April 2020 (02:51:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0461.v1

A Guide for the Bioinformatic Analysis of Metabolomics Data

Guillem Santamaria, Francisco R Pinto

Subject: Biology And Life Sciences, Other Keywords: metabolomics; bioinformatics; workflow; biostatistics; genome-scale metabolic modelling.

Online: 8 February 2024 (09:15:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0303.v2

Ten Simple Rules for FAIR Sharing of Experimental and Clinical Data with the Modeling Community

Matthias König, Jan Grzegorzewski, Martin Golebiewski, Henning Hermjakob, Mike Hucka, Brett Olivier, Sarah Keating, David Nickerson, Falk Schreiber, Rahuman Sheriff, Dagmar Waltemath

Subject: Biology And Life Sciences, Other Keywords: data sharing; FAIR

Online: 19 November 2021 (08:38:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0184.v1

Numerous Paradoxes Explained by Bandwagoning

Idan Solon

Subject: Biology And Life Sciences, Other Keywords: depression; nurturing; honest signaling; reproductive suppression; anthocyanins; hormesis

Online: 15 July 2019 (13:31:03 CEST)

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Background: Solon (2019) introduced genetic bandwagoning in a very general sense: A variant sequentially 1) evaluates its holder’s quality and 2) induces its holder to relinquish resources if the holder’s quality is low. Here, I introduce a more complex form of bandwagoning in order to account for a series of phenomena considered “paradoxical” by scientists specializing in their literatures: a) depression, b) differential nurturing, c) honest signaling of quality, d) reproductive suppression, e) stress-induced anthocyanins, and f) hormesis. These literatures are characterized by the following findings: 1) Low-quality individuals incur a cost against reproductive success compared to higher-quality individuals. 2) Individuals not (yet) identified as low-quality incur a cost against their ability to survive predators and/or parasites compared to individuals that have already been identified as low-quality. 3) Females incur a cost against reproductive success compared to males. 4) Males incur a cost against their ability to survive predators and/or parasites compared to females. 5) If conditions are challenging, individuals gain in both reproductive success and their ability to survive predators and/or parasites compared to less challenging conditions; however, too-challenging conditions detract from both. For each literature, at least one of these findings is unaccommodated by existing theory when considered in the context of that literature. Despite existing theory, these patterns are remarkably persistent. Question: Can paradoxes fitting these patterns be explained by genetic bandwagoning theory? Conclusion: Here, reservation is introduced as a form of bandwagoning in which a bandwagoning variant induces its holder to reserve from (i.e., withhold) some of its ability to survive parasites or predators. Reservation would occur for the purpose of assessing a holder’s quality when conditions are sufficiently unchallenging that few individuals are chronically stressed, so it is otherwise difficult to evaluate a holder’s quality. If the holder is subsequently killed, wounded, or infected, then it is identified as lacking the quality that would allow its descendants to survive more challenging conditions. The holder loses some or all of its resources as a direct consequence of the very death, wounding, or infection that identified its low quality. That is, in reservation, the two steps of bandwagoning are accomplished simultaneously. (This way of bandwagoning is distinguished from when the two steps are accomplished sequentially, which is termed resonation.) Reservation shares numerous premises with Zahavi’s handicap principle. If conditions are challenging, individuals would downregulate reservation and also be less likely to forego resources through resonation (which accounts for (5)). Additionally, a bandwagoning variant would likely evolve to vary the reservation it induces from holder to holder as a hedge against the possibility that conditions suddenly turn severe before it can adjust the reservation. Individuals already identified as low-quality would downregulate reservation (which accounts for (2) above) and would instead forego resources through resonation (which accounts for (1)). Additionally, females would downregulate reservation (which accounts for (4)) and, as a consequence, surviving females are more likely than surviving males to forego resources through resonation (which accounts for (3)).

Preprint REVIEW | doi:10.20944/preprints202206.0119.v1

Health System and Policy Analysis: Why There Is a Need for a Paradigm Shift in Our Approach to Improve Health Status of Brick-Kiln Migrant Workers in India?

Fnu Kajal

Subject: Biology And Life Sciences, Other Keywords: health policy; unorganised sector; brick-kiln workers; migrant; migration

Online: 8 June 2022 (08:54:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202212.0430.v1

EAQD-PC: Learning Model to Train Students' Metacognitive Skills to Overcome Difficulties in Learning Biology

Nurmi - Nurmi, Herawati Susilo, Ibrohim Ibrohim, Suhadi - Suhadi

Subject: Biology And Life Sciences, Other Keywords: EAQD-PC; Metacognitive skills; train and learning model

Online: 22 December 2022 (13:49:40 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202109.0530.v1

Energy Homeostasis Principle: A Naturalistic Approach to Explain the Emergence of Behavior

Sergio Vicencio, Mario Villalobos, Pedro Maldonado, Rodrigo Vergara

Subject: Biology And Life Sciences, Other Keywords: energy; homeostasis; neural network; behavior; free energy principle

Online: 30 September 2021 (17:49:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0085.v1

A Novel Method for Estimating Throwing Speed in Handball using a Wearable Device

Sebastian D Skejø, Jesper Bencke, Merete Møller, Henrik Sørensen

Subject: Biology And Life Sciences, Other Keywords: Accelerometer; throwing velocity; inertial measurement unit; throwing load; shoulder load

Online: 4 August 2020 (11:03:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0722.v1

A Theory of Intelligences

Michael E. Hochberg

Subject: Biology And Life Sciences, Other Keywords: Complexity; Difficulty; Embodiment; Efficiency; Evolution; Goals; Information; Optimization; Surprisal; Uncertainty

Online: 10 April 2024 (09:21:54 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0328.v3

Fan-shaped Spectrums of Species and Paleopolyploidy for Foundation of Crossbreeding Evolution

Li-Yuan Liu

Subject: Biology And Life Sciences, Other Keywords: Evolution; Speciation; Crossbreeding; Hybridization; Species spectrum; Polyploidization; Somatic cell hybridization; Mutation

Online: 3 March 2022 (10:25:51 CET)

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Working Paper CONCEPT PAPER

Extending the Explanatory Scope of Evolutionary Theory: The Origination of Historical Kinds in Biology and Culture

Günter P. Wagner, Gary Tomlinson

Subject: Biology And Life Sciences, Other Keywords: historical kinds; individuation; cultural evolution; evolutionary innovation

Online: 22 September 2020 (08:45:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201911.0205.v1

Factors Influencing the Disaster-Incident-Related Shock Experienced by Korean Nursing Students

Sohyune R. Sok, Minkyung Gu, Ran Kim, Hyunjung Lee

Subject: Biology And Life Sciences, Other Keywords: disasters; health status; coping skill; nursing student

Online: 17 November 2019 (13:44:29 CET)

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Preprint SHORT NOTE | doi:10.20944/preprints202206.0032.v1

Application of the Bayesian Conformity Assessment Framework from JCGM 106:2012 for Lot Inspection on the Basis of Single Items

Steffen Uhlig, Bertrand Colson, Rainer Göb, Petra Gowik

Subject: Biology And Life Sciences, Other Keywords: Conformity assessment; lot inspection; acceptance sampling; Quality level; sample size; Bayesian statistics; prior distribution; posterior distribution; consumer risk; producer risk

Online: 2 June 2022 (10:59:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1012.v1

Retrovirus-Derived RTL/SIRH Genes: Their Diverse Roles in the Current Eutherian Developmental System and Contribution to Eutherian Evolution

Tomoko Kaneko-Ishino, Fumitoshi Ishino

Subject: Biology And Life Sciences, Other Keywords: PEG10; PEG11/RTL1; RTL/SIRH genes; placenta; brain; innate immunity; human disease; mammalian development and evolution

Online: 14 August 2023 (09:58:16 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202208.0402.v1

Fitness, Optima, and Simplicity

Kamaludin Dingle

Subject: Biology And Life Sciences, Other Keywords: evolution; fitness; optimisation; algorithmic information theory

Online: 24 August 2022 (02:28:26 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202004.0025.v1

Extending the Explanatory Scope of Evolutionary Theory: The Origin of Historical Kinds in Biology and Culture

Gunter Wagner, Gary Tomlinson

Subject: Biology And Life Sciences, Other Keywords: historical kinds; individuation; cultural evolution; evolutionary innovation

Online: 3 April 2020 (04:28:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0101.v1

Greek Military Nursing Officers’ Leadership Style: Compassion Competence and Personal Level at Work

KLIMENTIDOU THOMAI, Pavlos Sarafis, IOANNIS APOSTOLAKIS, MARIA MALLIAROU

Subject: Biology And Life Sciences, Other Keywords: compassion; military nurse; leadership style

Online: 4 August 2022 (05:21:03 CEST)

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Abstract: The present study seeks to investigate MNOs leadership style and how it influences their compassion competence and their personal level of compassion at work. This is a cross-sectional study carried out from December 2019 to May 2020 using the method of convenience sampling. The study involved 235 MNOs serving in Greek Military Hospitals. A single questionnaire containing Compassion at Work index, Compassion competence scale, and Multifactor Leadership Questionnaire (MLQ-5X), and socio-demographic and professional data, was used for data collection. A total of 400 printed questionnaires were distributed with a response rate of 58.75%. Data analysis was performed using the statistical package SPSS 22.0. The research showed that the transformational and transactional leadership styles coexist in the Nursing Corps of the Armed Forces with an average value of 2.72(SD=0.70)-2.95(SD=0.54) points and 2.47(SD=0.69)-2.74(SD=0.63) points respectively, while the passive style represented a very small percentage with an average subscale value of 0.88(SD=0.61)-0.94(SD=0.63) points. It was also found that both actual compassion at work and compassion ability had improved with the increase of transformational or transactional leadership style characteristics and amelioration of leadership outcome criteria. On the other side, a deterioration of these was observed with the increase of the passive leadership. Specifically, a higher score in the «Intellectual Stimulation» scale was associated with a higher level of compassion at work in the dimension «Experiencing the suffering of others» (p=0.010/SD=0.14), while higher values on the «Laissez-Faire Leadership» scale were associated with less compassion at work in the same dimension (p<0.001/SD=0.13). Also, a higher score on the «Contingent Reward» scale was associated with more compassion at work in the dimension «Takes appropriate action» (p=0.023/SD=0.16). Furthermore, higher values observed in the «Inspirational Motivation», «Individual Consideration» and «Extra Effort» scales were associated with a better communication ability (p=0.035/SD=0.09, p=0.022/SD=0.12, and p=0.042/SD=0.08 accordingly). Finally, a higher score on the «Effectiveness» scale was associated with higher sensitivity (p=0.049/SD=0.08). Teaching appropriate leadership behavior, promoting a culture of compassion, and continuing to train nurses to manage their emotions should be included in the infrastructure of nursing science.

Preprint REVIEW | doi:10.20944/preprints202310.0557.v1

Applications Of Stem Cell-Derived Extracellular Vesicles in Nerve Regeneration

Burcak Yavuz, Esra Mutlu, Zubair Ahmed, Besim Ben-Nissan, ARTEMIS STAMBOULIS

Subject: Biology And Life Sciences, Other Keywords: nerve regeneration; non-coding RNAs; exosome; traumatic brain injury; blood-brain barrier

Online: 10 October 2023 (03:25:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0550.v1

Heat, Heatwaves and Cardiorespiratory Hospital Admissions in Helsinki, Finland

Hasan Bin Sohail, Pekka Tiittanen, Virpi Kollanus, Alexandra Schneider, Timo Lanki

Subject: Biology And Life Sciences, Other Keywords: Heat; Heatwave; Cardiovascular diseases; Respiratory diseases; Hospital admissions; Climate change; ambient temperature; Public health; time series; summer months

Online: 23 September 2020 (10:32:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0260.v1

Evaluating the Sensitivity of Heat Wave Definitions Among North Carolina Physiographic Regions

Jagadeesh Puvvula, Azar Abadi, Kathryn Conlon, Jared Rennie, Hunter Jones, Jesse Bell

Subject: Biology And Life Sciences, Other Keywords: Heat Wave; Heat-related illness; Early heat-health warning systems

Online: 18 July 2022 (10:14:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0211.v1

Assessment of the Impacts of Anthropogenic Activities on a Large River Using Longfin Eel as a Bioindicator

Olivier Champeau, James Ataria, Grant Northcott, Gen Kume, Andrew Barrick, Louis A. Tremblay

Subject: Biology And Life Sciences, Other Keywords: New Zealand; biomarkers; environmental health assessment; Anguilla dieffenbachii

Online: 9 September 2020 (11:45:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0253.v1

Links between Serotonin Levels and Stress: Cortisol, Candida A./Mycetes, Omega 3/6 Ratio and Dysbiosis (Skatole/Indoxyl Sulfate) Role in Chronic Fatigue Syndrome (CFS) and Depression

Daniele Orlandoni, Giuseppe Di Fede, Mauro Mantovani, Consuelo Rubina Nava, Marco Tomasi, Paola Fusi

Subject: Biology And Life Sciences, Other Keywords: stess; chronic fatigue syndrome; depression; dysbiosis; serotonin/cortisol

Online: 5 September 2023 (07:52:50 CEST)

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Intestinal microbiota attracts daily attention of a growing number of study which have attempted to link gut dysbiosIs with a variety of disease states: irritable bowel syndrome (IBS), inflamed bowel disease (IBD), Crohn's disease (CD), leaky gut syndrome (LGS), food intolerance, diabetes, metabolic syndrome, cancer, etc.. In our study we analyzed how intestinal dysbiosis may be related to chronic fatigue syndrome (CFS) and depression through the exchange of information through the gut-brain axis (GBA). We studied 33 subjects, 13 males and 20 females, who reported CFS or/and depression: we investigated their salivary cortisol levels, blood serotonin, omega 3/6 ratio, intestinal dysbiosis (calculated on the urinary levels of indoxyl sulfate and skatole), and we looked for the presence of Candida a. or mycetes in the stool; the data accumulated with this research show a correlation between the presence of Candida a./miceti, indoxyl sulfate urine values beyond the physiological and low serotonin levels. In addition, data analysis showed that the EPA/DHA values also show pro-inflammatory levels in case of dysbiosis and low serotonina levels. The relationship, however, with cortisol levels requires further research although this study showed a statistically significant positive correlation between these values, measured at specific times, and serotonin levels. Aims its connections with We investigated the relationship between stress (evaluated through the measurement of salivary cortisol levels) and gastrointestinal efficiency measured as a function of intestinal fermentative and putrefactive dysbiosis, evaluating the levels of urinary indoxyl sulfate in the first case (a possible correlation with the presence of Candida spp or Mycetes in the subjects feces was investigated), urinary skatole levels in the second one, in patients with chronic fatigue syndrome (SFC) and depression. In these patients we also have studied omega 3/6 ratio, and finally we have analized the impact that the alteration of these parameters can have on the serotonin levels. This research attemps to highlight the contact points, in some cases not so obvious, among these topics, contact points that, although they give us interesting indications, show the need to be further deepened by analyzing a larger amount of data.

Preprint REVIEW | doi:10.20944/preprints202304.0677.v1

Simultaneous Quantitation and Discovery (SQUAD) Analysis: Combining the Best of Targeted and Untargeted Mass Spectrometry-Based Metabolomics

Bashar Amer, Rahul R. Deshpande, Susan S. Bird

Subject: Biology And Life Sciences, Other Keywords: Metabolomics; Simultaneous Quantitation and Discovery (SQUAD); Targeted Metabolomics; Untargeted Metabolomics

Online: 21 April 2023 (07:29:13 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202211.0164.v1

Ten Simple Rules for Easily Establishing Your First Professional Social Media Page for Job Hunting

Abril Zuniga, Carl Westin, Christopher Smith, Cole Souza, Robin Zamora, Cristal Zuniga

Subject: Biology And Life Sciences, Other Keywords: Social media; professional network; linkedin

Online: 9 November 2022 (02:05:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0662.v1

Meat-Borne-Parasite: A Nanopore-Based Meta-Barcoding Workflow for Parasitic Microbiodiversity Assessment in the Wild Fauna of French Guiana

Adria MATOUTE, Simone MAESTRI, Mona SAOUT, Laure LAGHOE, Stephane SIMON, Helene BLANQUART, Miguel Angel Hernandez Martinez, Magalie PIERRE DEMAR

Subject: Biology And Life Sciences, Other Keywords: Apicomplexa; Amazon; NGS sequencing; Meta-barcoding; Wild mammals

Online: 12 February 2024 (10:24:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202402.1314.v1

Do Low-Income Consumers of Forage Fish Subsidize the Production of Aquafeeds? Financial and Nutritional Significance

Amir Neori

Subject: Biology And Life Sciences, Other Keywords: ; overfishing; poor families, fisherfolk, fishmeal; natural food chain; anchovy; sardines; social justice; supply and price; fish market ;

Online: 22 February 2024 (12:21:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.0508.v1

SPHN Strategy to Unravel the Semantic Drift Between Versions of Standard Terminologies

Deepak Unni, Vasundra Touré, Philip Krauss, Katrin Crameri, Sabine Österle

Subject: Biology And Life Sciences, Other Keywords: standards, ontologies; semantic drift; versioning; semantic web; FAIR principles

Online: 7 December 2023 (10:28:20 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.1774.v1

Not Only Editing: A Cas-Cade of CRISPR/Cas-Based Tools for Functional Genomics in Plants and Animals

Aurélien Devillars, Gabriele Magon, Carlotta Pirrello, Fabio Palumbo, Silvia Farinati, Gianni Barcaccia, Margherita Lucchin, Alessandro Vannozzi

Subject: Biology And Life Sciences, Other Keywords: CRISPR/Cas; Imaging; Gene regulation; NGS; Viruses; CRISPR/Cas9; CRISPR/Cas13; dCas9

Online: 25 January 2024 (01:57:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.0123.v1

Novel Entropy-Based Phylogenetic Algorithm: A New Approach for Classifying SARS-CoV-2 Variants

Vladimir Perovic, Sanja Glisic, Milena Veljkovic, Slobodan Paessler, Veljko Veljkovic

Subject: Biology And Life Sciences, Other Keywords: Entropy; Electron-Ion Interaction Potential; COVID-19; Phylogenetic analysis; SARS-CoV-2

Online: 2 August 2023 (03:29:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.2238.v1

N-glycosylation as a Modulator of Protein Conformation and Assembly in Disease

Chiranjeevi Pasala, Tanaya Roychowdhury, Sahil Sharma, Elisabetta Moroni, Giorgio Colombo, Gabriela Chiosis

Subject: Biology And Life Sciences, Other Keywords: N-glycosylation; disease; conformational mutant; aberrant protein assembly; energy landscape; SARS-CoV-2 spike protein; glucose regulated protein 94 (GRP94); prion protein; disease-associated protein conformation; protein dynamics; protein assembly mutation; gain-of-function conformational change

Online: 31 January 2024 (14:12:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1481.v1

Identification and Characterization of ten Escherichia coli Strains encoding Novel Shiga Toxin 2 Subtypes, Stx2n as well as Stx2j, Stx2m, and Stx2o, in the United States

Rebecca L Lindsey, Arjun Prasad, Michael Feldgarden, Narjol Gonzalez-Escalona, Curtis Kapsak, William Klimke, Angela Melton-Celsa, Peyton Smith, Alexandre Souvorov, Jenny Truong, Flemming Scheutz

Subject: Biology And Life Sciences, Other Keywords: Shiga Toxin-Producing Escherichia coli; Shiga toxin subtype; Stx2n; Genome Sequence

Online: 21 September 2023 (11:26:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.0824.v1

Fungal Diversity and Heritage Degradation

Manuela Oliveira, Johnny Reis, Michel Almaguer

Subject: Biology And Life Sciences, Other Keywords: cultural heritage; monument degradation; fungal diversity; preservation and restoration

Online: 12 October 2023 (11:59:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202007.0328.v2

Fan-shaped Spectrums of Species and Paleopolyploidy for Foundation of Crossbreeding Evolution

Li-Yuan Liu

Subject: Biology And Life Sciences, Other Keywords: Evolution; Speciation; Crossbreeding; Hybridization; Species spectrum; Polyploidization; Mutation

Online: 30 November 2021 (11:04:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1600.v1

Macronutrients Intake, and Performance of Professional Football Players from Morocco in a Pre-season Training Period

Mourad Oukheda, Khawla Bouaouda, Karima Mohtadi, Halima Lebrazi, Abdelfettah Derouiche, Anass Kettani, Rachid Saïle, Hassan Taki

Subject: Biology And Life Sciences, Other Keywords: Dietary Intake; Macronutrients; Sport Nutrition; Sport Performance; Football; VO2max

Online: 23 August 2023 (09:35:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0200.v1

Advances in Hair Growth: Beneficial Effects of a New Product Formulated with Amplex plus Technology on Hair Follicles Regeneration

Greta Ferruggia, Martina Contino, Massimo Zimbone, Maria Violetta Brundo

Subject: Biology And Life Sciences, Other Keywords: hair follicles; regeneration; alopecia; colostrum; growth factors

Online: 3 November 2023 (11:17:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1628.v1

Spatio-Temporal Patterns of the SARS-CoV-2 Epidemic in Germany

Hans H. Diebner

Subject: Biology And Life Sciences, Other Keywords: COVID-19; SARS-CoV-2; Epidemic Spatial Heterogeneity; Diversity; Spatio-Temporal Patterns; Cluster Analysis

Online: 22 June 2023 (12:45:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0646.v1

Pacing Strategy of 800-Meter and 1500-Meter Freestyle Swimming Finals in the World Championships According to the Performance in Males and Females of Different Age Groups

Sabrina Demarie, Jean Renaud Pycke, Alessia Pizzuti, Veronique Billat

Subject: Biology And Life Sciences, Other Keywords: energy cost; endurance; training; technique; tactic; fatigue; performance; time series; mathematical modelling; sex difference

Online: 11 September 2023 (14:45:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1389.v1

Sleep Disorders in Pediatrics Associated to Underlying Diseases. Cross Sectional Study

Martin esteban Gruenberg, Marcela Kalina, Veronica andrea Peuchot

Subject: Biology And Life Sciences, Other Keywords: sleep; sleep problem; conductual sleep disorder; night awakening; sleep coach

Online: 19 December 2023 (07:08:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0713.v1

Development of Multiplex Molecular Assay for Simultaneous Detection of Dengue serotypes and Chikungunya virus for arbovirus surveillance

Louis Robert W BELEM, Sylvester Agha Ibemgbo, Michel Kiréopori Gomgnimbou, Antoinette Kaboré, Dileep Kumar Verma, Ankit Kumar, Ibrahim Sangare, Sujatha Sunil

Subject: Biology And Life Sciences, Other Keywords: multiplex; molecular; detection; dengue virus; chikungunya virus; arbovirus

Online: 9 January 2024 (14:33:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0643.v1

Phytophthora Communities Associated with Agathis australis (kauri) in Te Wao Nui o Tiriwa/Waitākere Ranges, New Zealand

Shannon Hunter, Ian Horner, Jack Hosking, Ellena Carroll, Jayne Newland, Matthew Arnet, Nick Waipara, Bruce Burns, Peter Scott, Nari Williams

Subject: Biology And Life Sciences, Other Keywords: Phytophthora; Agathis australis; kauri dieback; community structure; soil baiting; metabarcoding; New Zealand; epidemiology; invasive pathogen; forest management

Online: 11 March 2024 (18:00:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.1674.v1

Present Status of Endemic Plants of Bangladesh

Md. Salah Uddin, Abdullah Al Masud Mazumder, Sang Woo Lee, Shaikh Bokhtear Uddin

Subject: Biology And Life Sciences, Other Keywords: endemic plants; updated list; bangladesh flora

Online: 27 November 2023 (07:56:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.2210.v1

Potential Role of Antibodies Against Aquaporin-1 in Patients with Central Nervous System Demyelination

Maria Pechlivanidou, Konstantina Xenou, Dimitrios Tzanetakos, Emmanuel Koutsos, Christos Stergiou, Elisabeth Andreadou, Konstantinos Voumvourakis, Sotirios Giannopoulos, Constantinos Kilidireas, Erdem Tüzün, Georgios Tsivgoulis, Socrates Tzartos, John Tzartos

Subject: Biology And Life Sciences, Other Keywords: aquaporins; AQP4; AQP1; antibodies; autoimmunity; CNS demyelination; NMOSD

Online: 30 June 2023 (10:16:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1277.v1

Mapping the Landscape of Proprioception Research in Gymnastics: A Bibliometric Analysis and Systematic Review

Andrea Fallas-Campos, Jesús Muñoz-Jiménez, Kiko León, Dainel Rojas-Valverde

Subject: Biology And Life Sciences, Other Keywords: body control; awareness; balance; training; assessment

Online: 20 September 2023 (03:28:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1236.v1

Investigation Detection of Antibody+Antigen Complexes by SOI-FET Biosensor

Vladimir Generalov, Anastasia Cheremiskina, Aleksandr Glukhov, Victoria Grabezhova, Margarita Kruchinina, Aleksandr Safatov

Subject: Biology And Life Sciences, Other Keywords: biosensor; SOI-FET; transistor; detection; virus; particles; probability; plausibility

Online: 16 June 2023 (11:49:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.1250.v1

A Review on Genus Paramacrobiotus

Pushpalata Kayastha, Monika Mioduchowska, Łukasz Kaczmarek

Subject: Biology And Life Sciences, Other Keywords: tardigrade; reproduction; taxonomy; distribution; microbiome

Online: 18 July 2023 (14:14:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202311.1819.v1

Machine Learning to Advance Human Genome‐Wide Association Studies

Rafaella Sigala, Vasiliki Lagou, Aleksey Shmeliov, Sara Atito, Samaneh Kouchaki, Muhammad Awais, Inga Prokopenko, Adam Mahdi, Ayse Demirkan

Subject: Biology And Life Sciences, Other Keywords: genome‐wide association; human genetics; machine learning

Online: 28 November 2023 (15:41:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202307.1838.v1

Complexation of Terpenes for the Production of New Antimicrobial and Antibiofilm Molecules and Their Encapsulation in Order to Improve Their Activities

Yousra EL Fannassi, Adem Gharsallaoui, Simon Khelissa, Mohamed Amin El Amrani, Isabelle Suisse, Mathieu Sauthier, Charafeddine Jama, Saïd Boudra, Nour-Eddine Chihib

Subject: Biology And Life Sciences, Other Keywords: terpenes; metallic ions; complexes; microencapsulation; biofilm

Online: 28 July 2023 (10:49:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1519.v1

A Systematic Review of Dynamic Forces and Kinematic Indicators in the Front and Roundhouse Kicks Across Varied Conditions and Participant Experience.

Michal Vagner, Daniel John Cleather, Vladan Olah, Jan Vacek, Petr Stastny

Subject: Biology And Life Sciences, Other Keywords: biomechanics; martial arts; impact force; maximum velocity

Online: 21 June 2023 (10:01:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0195.v1

Eigenfemora – Age at Death Estimation in the Proximal Femur through an Image Processing Approach

David Navega, Maria Teresa Ferreira, Francisco Curate

Subject: Biology And Life Sciences, Other Keywords: biological profile; radiology; bone loss; forensic anthropology

Online: 3 November 2023 (11:14:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202402.0519.v1

Objective Assessment of Equine Locomotor Symmetry using Inertial Sensors System and Artificial Intelligence: A Comparative Study

Natalie Calle-González, Chiara Maria Lo Feudo, Francesco Ferrucci, Francisco Requena, Luca Stucchi, Ana Muñoz

Subject: Biology And Life Sciences, Other Keywords: Artificial Intelligence; Gait Analysis; Horse; Inertial Measurement Units System; Locomotion.; Lameness

Online: 8 February 2024 (14:09:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.2027.v1

Analysis of Gene Expression Networks in Primary Central Nervous System Tumors for Drug Repurposing Prospects

Brian Harvey Avanceña Villanueva, Po-Wei Tsai, Lemmuel L. Tayo

Subject: Biology And Life Sciences, Other Keywords: central nervous system tumor; co-expression network; drug repurposing

Online: 30 August 2023 (09:04:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1498.v1

Plants Profile of Sultan Khail Valley, Hindukush Range of Pakistan: Floristic Composition, Biological Spectrum and Its Seasonal Variation

Khaista Rahman, Naveed Akhtar

Subject: Biology And Life Sciences, Other Keywords: Floristic composition; Biological Spectrum; Sultan Khail Valley; Pakistan

Online: 22 September 2023 (08:32:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.0346.v1

Artificial Populations in Agent-Based Modeling

Oksana Glushchenko, Aleksander Manolov, Ivan Kozlov, Vera Tsurkis, Irina Maslova, Nikolay Popov, Andrey Samoilov, Alexandr Lukashev, Elena Ilina

Subject: Biology And Life Sciences, Other Keywords: agen based modeling; COVID-19; digital epidemiology

Online: 6 December 2023 (12:34:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202311.0380.v1

Fifteen Years after the Definition of Trypanosoma cruzi DTUs: What Have We Learned?

Bianca Zingales, Andréa M Macedo

Subject: Biology And Life Sciences, Other Keywords: Trypanosoma cruzi; Discrete Typing Units; genomics; Chagas disease manifestations; ecoepidemiology

Online: 7 November 2023 (11:40:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1600.v1

Rutin Promotes Proliferation and Orchestrates Epithelial-Mesenchymal Transition and Angiogenesis in Human Breast Cancer Cells

Homa Hajimehdipour, Zahra Tahmasvand, Fatemeh Ghorban Nejad, Marc Maresca, Sadegh Rajabi

Subject: Biology And Life Sciences, Other Keywords: Breast cancer; Rutin; Epithelial-Mesenchymal Transition; Metastasis; Angiogenesis

Online: 23 May 2023 (07:41:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1921.v1

Pre-season ACL Risk Classification of Professional and Semi-professional Football Players, via a Holistic Test-battery

Charis Tsarbou, Nikolaos Liveris, Sofia Xergia, Maria Tsekoura, Konstantinos Fousekis, Elias Tsepis

Subject: Biology And Life Sciences, Other Keywords: ACL; screening; injury-risk; prevention; LESS; asymmetry; soccer

Online: 26 May 2023 (10:42:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1875.v1

The Perspectives of Key Stakeholders on the Reintroduction of Apex Predators to the United Kingdom.

Shannon Wilson, Marco Campera

Subject: Biology And Life Sciences, Other Keywords: rewilding; wolf; bear; lynx; farmers; attitudes; public opinion; attitudes; deer

Online: 25 December 2023 (12:22:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202308.1168.v1

Selective Impact of Selenium Compounds on Two Cytokine Storm Players

Indu Sinha, Junjia Zhu, Raghu Sinha

Subject: Biology And Life Sciences, Other Keywords: methylseleninic acid; sodium selenite; selenous acid; selenomethionine, cytokines, cytokine storm; COVID-19

Online: 16 August 2023 (08:06:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1993.v1

Enhanced Expression of Glycolytic Enzymes and Succinate Dehydrogenase Complex Flavoprotein Subunit A by Mesothelin Promotes Glycolysis and Mitochondrial Respiration in Myeloblasts of Acute Myeloid Leukemia

Yunseon Jang, Jeong Suk Koh, Jung-Hyun Park, Suyoung Choi, Pham Thi Thuy Duong, Bu Yeon Heo, Sang Woo Lee, Jung Yeon Kim, Myung-Won Lee, Seok-Hwan Kim, Ik-Chan Song

Subject: Biology And Life Sciences, Other Keywords: mesothelin; acute myeloid leukemia; glycolysis; oxygen consumption rate

Online: 30 November 2023 (13:38:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.1138.v1

The Presence of the Human Auditory Ossicles -Detected Post-mortem by CT Scan- as a Taphonomic Indicator

Edda Emanuela Guareschi, Sara Poggesi, Marco Palmesino, Paola Annarosa Magni

Subject: Biology And Life Sciences, Other Keywords: burial; entombment; ossicular chain; postmortem imaging; postmortem interval; preservation; submersion

Online: 18 September 2023 (09:33:58 CEST)

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Three tiny bones compose the human ossicular chain: malleus, incus and stapes. Also known as auditory ossicles, they are united by joints in the middle ear cavity of the petrous part of the temporal bone. Completely developed 2 years after birth, the ossicular chain is involved in the physiological process of hearing, by which sound waves from the environment are converted into electrochemical impulses. In the last 500 years, most studies have focussed on the morphogenesis, morphological variability and clinical pathology of the ossicular chain, whilst only a few studies have added relevant knowledge to anthropology and forensic science. The auditory ossicles and the enclosing petrous bone are some of the hardest in the human skeleton. This reflects in a relative resistance to fire. In the post mortem period and in favourable circumstances, the auditory ossicles can fossilize and survive for millions of years. Post mortem loss in skeletal or decomposed remains can be ascribed to their destruction or physical displacement, by either macro-micro-faunal action and/or any other natural or artificial disturbance. Physical displacement is closely connected to the depositional environment of the skeletal remains, such as burial, entombment (sarcophagus, coffin, vault…), submersion or exposure to natural elements. Auditory ossicles can be recovered in situ, or very close to their anatomical location, when the skeletal material has been involved in an archaeological excavation. In the case of accessible or disturbed remains, scavengers may remove the tiny ossicles, and/or they can slip out of the middle ear cavity following skull movements. Entombment offers an effective protection against the displacement of the auditory ossicles, whereas aquatic submersion and aquatic movement almost invariably displace them. The preservation of the human auditory ossicles should be critically considered in the comprehensive context of any forensic investigation on human remains, since it can assist the reconstruction of their taphonomic history. Taphonomic histories of remains can add crucial information to forensic investigations (e.g., the Post Mortem Interval, PMI). The aim of this study, limited by scarce relevant literature, is to discuss the potential role of the ossicular chain, detected by post mortem imaging techniques, as a taphonomical indicator in decomposing and/or skeletonized bodies.

Preprint ARTICLE | doi:10.20944/preprints202306.1908.v1

Deep Dive Into the DNA Polymerase Through Insilico Analysis: An Information to Get Better PCR Enzyme From the Ancient One

Debanjan Mitra

Subject: Biology And Life Sciences, Other Keywords: Polymerase chain reaction; DNA polymerases; Intra-protein interactions; Protein satbility

Online: 27 June 2023 (12:46:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0878.v1

Cold Atmospheric Plasma Jet Treatment Decreases the Survival and the Expression of Oncogenic miRNAs of Oral Carcinoma Cell

Yun-Chien Cheng, Kuo-Wei Chang, Jian-Hua Pan, Chao-Yu Chen, Chung-Hsien Chou, Hsi-Feng Tu, Wan-Chun Li, Shu-Chun Lin

Subject: Biology And Life Sciences, Other Keywords: AKT; cold atmospheric plasma; ERK; miRNA; oral carcinoma

Online: 13 October 2023 (10:04:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0172.v1

Explore the Legal Challenges and Coping Strategies for the Development of New Biomedical Technologies

Zhangsheng Sun, Xinyan Li

Subject: Biology And Life Sciences, Other Keywords: ; biomedical ethics; New biomedical technologies; Legal challenges; Coping strategies

Online: 4 March 2024 (14:06:22 CET)

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New biomedical technologies are examined in depth and the legal and ethical challenges they pose. Key issues such as gene editing, the application of artificial intelligence in the medical field, and the protection of biological information data are analyzed. At the same time, we also found that technological advances in the development of the enormous potential of biomedicine, but also raises a series of ethical and legal issues. To this end, the paper proposes a series of effective response strategies aimed at providing guidance to policy makers, researchers, and healthcare professionals to ensure the rational and safe application of new technologies. Solutions to these challenges are elaborated. When it comes to gene editing, the article stresses the responsibility of scientists not only to push the boundaries of technology, but also to ensure that edited genes are in the public interest and respect individual rights. To this end, strict regulatory mechanisms should be put in place to ensure that gene editing is carried out only in certain and ethical circumstances. Although AI technology has brought many conveniences to the medical field, it also involves data privacy protection, the transparency of the AI decision-making process, and the impact of AI on traditional medical models. Therefore, it is necessary to formulate corresponding regulations to regulate its application, ensure the fairness and transparency of AI decision-making, and promote its integration and development with traditional medicine. The importance of the protection of biometric data was also emphasized. In biomedical research, a large number of personal biological information data, such as genome and proteome, are often involved. This data should be effectively protected to prevent data leakage and misuse. To this end, it is necessary to strengthen data security measures and establish standards and norms for data sharing and utilization to ensure the rational use and protection of data.

Preprint ARTICLE | doi:10.20944/preprints202306.0774.v1

Domestic Reuse Status of Invasive Turtle Species Trachemys scripta in South Korea

Hae-jun Baek, Soyeon Cho, Minjeong Seok, Joo-won Shin, Dae-in Kim

Subject: Biology And Life Sciences, Other Keywords: animal release; invasive species management; South Korea; traditional markets; Trachemys scripta

Online: 12 June 2023 (05:43:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1067.v1

Boundaries of Alfalfa Field and Their Function as Refuge for Butterfly (Lepidoptera: Rhopalocera) Communities

Sombra Patricia Rivas Arancibia, Paola Fascinetto Zago, Agustina Rosa Andrés hernandez, Natalie Olmos Santiago, David Martínez Moreno

Subject: Biology And Life Sciences, Other Keywords: diurnals butterflies; farmland; edges flora; migratory butterflies

Online: 17 July 2023 (10:30:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1797.v1

Nightingale: Web components for protein feature visualization

Gustavo A Salazar, Aurelien Luciani, Xavier Watkins, Swaathi Kandasaamy, Daniel L Rice, Matthias Blum, Alex Bateman, Maria Martin

Subject: Biology And Life Sciences, Other Keywords: Visualization, Bioinformatics, Proteins, Software, Web services

Online: 25 May 2023 (10:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202312.1303.v1

In and Out Beauty and Sensitive Skin, a Psychophysiological Exploration: Myth or Reality?

Leila Falcao, Rachida Nachat Kappes, Edith Filaire

Subject: Biology And Life Sciences, Other Keywords: sensitive skin; cortisol; dehydroepiandrosterone; saliva; emotion

Online: 18 December 2023 (12:25:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0169.v1

The Supersymmetry Genetic Code Table and Quadruplet Symmetries of DNA Molecule Are the Unchangeable and Synchronized with the Codon Free Energy Mapping during Evolution

Marija Rosandic, Vladimir Paar

Subject: Biology And Life Sciences, Other Keywords: genetic code symmetry, mitochondrial genetic code, energy code, DNA quadruplet symmetry, classification of trinucleotides/codons

Online: 4 October 2023 (07:43:22 CEST)

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The Supersymmetry Genetic code (SSyGC) table is based on five physicochemical symmetries: 1) double mirror symmetry on the principle of the horizontal and vertical mirror symmetry axis between all bases (purines [A, G) and pyrimidines (U, C)], and 2) of bases in form of codons 3) direct – complement like codon/anticodon symmetry in the sixteen alternating boxes of the genetic code columns, 4) A+T rich and C+G rich alternate codons in the same row between both columns of the genetic code, 5) the same position between divided and undivided codon boxes in relation to horizontal mirror symmetry axes. The SSyGC table has a unique physicochemical purine – pyrimidine symmetry net which is as the core symmetry common for all, more than thirty different nuclear and mitochondrial genetic codes. This net is present in the SSyGC table of all RNA and DNA living species. None of these symmetries is present in the Standard Genetic Code (SGC) table which is constructed on the alphabetic horizontal and vertical U-C-A-G order of bases. Here we show that the free energy value of each codon incorporated as fundamentally mapping the “energy code” in the SSyGC table is compatible with mirror symmetry. On the other hand, in the SGC table the same free energy values of codons are dispersed and a mirror symmetry between them is not recognizable. At the same time the mirror symmetry of the SSyGC table and the DNA quadruplets together with our classification of codons/trinucleotides are perfectly imbedded in the mirror symmetry energy mapping of codons/trinucleotides and point out in favor of maintaining the integrity of the genetic code and DNA genome. We also argue that physicochemical symmetries of the SSyGC table in the manner of the purine – pyrimidine symmetry net, the quadruplet symmetry of DNA molecule and the free energy of codons have remined unchanged during all of evolution. The unchangeable and universal symmetry properties of the genetic code, DNA molecule and energy code are decreasing disorder between codons/trinucleotides and shed a new light on evolution. Diversity in all living species on Earth is broad, but the symmetries of the Supersymmetry Genetic Code as the code of life and the DNA quadruplets related to the” energy code” are unique, unchangeable and have the power of natural laws.

Preprint REVIEW | doi:10.20944/preprints202308.0334.v1

Biodeterioration and Chemical Corrosion of Concrete in the Marine Environment: Too Complex for Prediction

Christine Claire Gaylarde, Benjamin Otto Ortega

Subject: Biology And Life Sciences, Other Keywords: biofilm; colonization; degradation; microorganisms; subtidal, intertidal and splash zones; extracellular polymeric materials (EPS)

Online: 3 August 2023 (10:52:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1042.v1

Circulating Sphingolipids in Obesity, Insulin Resistance, Diabetes and Associated Complications

Samar M. Hammad, Maria F Lopes-Virella

Subject: Biology And Life Sciences, Other Keywords: Sphingolipid, Diabetes, Obesity, Insulin Resistance, Metabolic Syndrome, Diabetic Kidney Disease, Cardiovascular Disease, Diabetic Complications

Online: 14 August 2023 (11:14:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0320.v4

Ten Simple Rules for Using Public Biological Data for Your Research

Vishal Oza, Jordan Whitlock, Elizabeth Wilk, Angelina Uno-Antonison, Brandon Wilk, Manavalan Gajapathy, Timothy Howton, Austyn Trull, Lara Ianov, Elizabeth Worthey, Brittany Lasseigne

Subject: Biology And Life Sciences, Other Keywords: data; reproducibility; FAIR; data reuse; public data; big data; analysis

Online: 2 November 2022 (02:55:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202401.0024.v1

Role of Rare Species on Phytoplankton Size-Abundance Relationships and Size-Structure across Different Biogeographical Areas

Maira Laraib, Jessica Titocci, Antonia Giannakourou, Sofia Reizopoulou, Alberto Basset

Subject: Biology And Life Sciences, Other Keywords: rarity; phytoplankton; taxonomic diversity; morpho-functional traits; size-abundance relationships; transitional waters

Online: 3 January 2024 (06:37:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.1332.v1

A Comprehensive Review of Natural Product as Therapeutic Agent for Head and Neck Squamous Cell Carcinoma Using Preclinical Model

Yoon Xuan Liew, Lee Peng Karen-Ng, Vui King Vincent-Chong

Subject: Biology And Life Sciences, Other Keywords: Head and neck squamous cell carcinoma; natural products; phytochemicals; chemotherapeutics; chemoprevention

Online: 19 June 2023 (09:04:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.0180.v1

Mapping of Bovine Tuberculosis in Colombia, 2001-2019

D. Katterine Bonilla-Aldana, S. Daniela Jiménez-Diaz, Carlos Losada, Kenneth Silva-Cajaleon, Alfonso J. Rodriguez-Morales

Subject: Biology And Life Sciences, Other Keywords: tuberculosis; infection; cattle; GIS; geographic information systems; Mycobacterium bovis; One Health

Online: 4 March 2024 (19:13:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202312.0605.v1

The Latest Trends in Cryopreservation of Fungi

Ivana Eichlerová

Subject: Biology And Life Sciences, Other Keywords: basidiomycetes; non-basidiomycete fungi; cryopreservation; long/short-term storage; liquid nitrogene; cryoprotectant

Online: 8 December 2023 (10:37:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.2201.v1

Regular Sport Activity Is Able to Reduce the Level of Genomic Damage

Alfredo Santovito, Angiolina Agostinovna Nigretti, Amedeo Sellitri, Manuel Scarfò, Alessandro Nota

Subject: Biology And Life Sciences, Other Keywords: Sport; Micronuclei; Gene Polymorphisms; Buccal Mucosa Cells

Online: 30 June 2023 (10:35:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.0636.v1

Syncephalastrum massiliense sp. nov. and Syncephalastrum timoneanum sp. nov., Isolated from Clinical Samples

Jihane Kabtani, Fatima BOULANOUAR, Papa Mouhamadou GAYE, Muriel Militiello, Stéphane Ranque

Subject: Biology And Life Sciences, Other Keywords: Mucormycosis; Mucorales; Syncephalastrum; genotype; phenotype

Online: 11 October 2023 (03:35:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0730.v1

CYP2C19 Pharmacogenetics and Clopidogrel Prescription in a University Hospital: A Descriptive Study in a Clinical Data Warehouse

Alexandre Maes, Laura Gosselin, Aude Triquenot, Stéfan Darmoni, Julien Grosjean, Fabien Lamoureux, Julien Wils

Subject: Biology And Life Sciences, Other Keywords: clopidogrel; pharmacogenetics; cytochrome P-450 CYP2C19; Clinical Data Warehouse; personalized medicine

Online: 12 September 2023 (07:15:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1977.v1

Shelf-Life Study of Probiotic Dahi Prepared by a New Isolated Probiotic, Lactobacillus acidophilus Strain JB2CON

Jakaria Mujahidy, Md. Ekhlas Uddin, Shahidur Rahman, A. N. M. Mamun-Or-Rashid

Subject: Biology And Life Sciences, Other Keywords: L. acidophilus JB2CON; probiotic dahi; shelf life; Escherichia coli

Online: 30 November 2023 (11:19:45 CET)

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Biology and Life Sciences