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Article
Biology and Life Sciences
Animal Science, Veterinary Science and Zoology

Nenad Mićić

,

Dragan Stanojević

,

Dragan R. Milićević

,

Miloš Marinković

,

Marina Lazarević

,

Ljiljana Samolovac

,

Vladan Bogdanović

Abstract: Milk production in dairy cattle is increasingly challenged by thermal variability. This underscores the need for reliable assessment of microclimatic conditions and their interaction with animal- and management-related factors to ensure sustainable dairy production. The aim of this study was to evaluate the effects of thermal variability and selected environmental and biological factors on key milk production traits in dairy cattle. The influence of fixed factors related to production conditions and microclimatic variability, including the Temperature–Humidity Index (THI), on daily milk yield (MY), milk fat content (MF), and milk protein content (MP) was assessed. The study used a dataset covering two observation periods of daily milk production traits in cows of different breeds (Simmental, Holstein-Friesian, Red Holstein, and Brown Swiss) reared in three regions of the Republic of Serbia (Mačva, Podunavlje, and Šumadija), enabling an assessment of thermal variability under diverse production and microclimatic conditions. The expression and variability of the investigated traits were determined using the PROC FREQ and PROC MEANS procedures, while the effects of individual factors were analysed using general linear and regression models, with results expressed as least squares means. All examined factors showed a highly significant effect on MY, MF, and MP (p < 0.0001). Although the overall level of heat stress was moderate, milk production was highest within the THI range of 51–60. These findings demonstrate that thermal variability significantly influences milk production and composition and highlight the importance of integrating microclimatic indicators into sustainability-oriented dairy management and breeding strategies.

Review
Biology and Life Sciences
Endocrinology and Metabolism

Jorge Tamarit Rodriguez

Abstract: Since the pioneering work of Dean P. M. and Matthew E. K. (1970), four decades have elapsed without any consensus on the mechanism responsible for the oscillations of the plasma membrane voltage exhibited by pancreatic β-cells stimulated by glucose. In this review, the different hypothesis dealing with the cause of voltage oscillations that lead to insulin secretion pulsatility will be commented. The earliest explanation attributed the voltage oscillations (bursting) to glycolytic oscillations, taking as a reference skeletal muscle glycolysis oscillations. Later, the scientific interest moved to glucose oxidation after discovering that some mitochondrial parameters also oscillated in synchrony with membrane voltage oscillations. As [Ca2+]cyt increases resultant from membrane depolarization oscillated in synchrony with membrane bursting, it competed with metabolic oscillations (e.g. cytosolic ATP/ADP) for being the cause or the effect of insulin pulsatility; it was demonstrated that metabolic oscillations preceded [Ca2+]cyt oscillations. We are contributing with the hypothesis attributing the cause of voltage oscillations to a sequential competition of two β-cell plasma membrane channels: K+ATP channel and Cx36 hemichannel (Cx36H). Whereas increased glucose metabolism (increased ATP/ADP) closures K+ATP channels and depolarizes the plasma membrane (active phase of a bursting), Cx36Hs are opened and repolarize the membrane potential with a certain delay by inhibiting glucose metabolism (silent phase of a bursting). Repolarization, in turn, closes Cx36H and allows the recovery of glucose oxidation and beginning of a new active phase.

Article
Physical Sciences
Theoretical Physics

W. A. Tiefenbrunner

Abstract: In 1916, A. Einstein developed a model of the absorption and emission of radiation from which he derived M. Planck’s radiation law. He postulated light-induced (stimulated) emission, because within the framework of classical physics an oscillator can, depending on the phase difference, both extract energy from the electromagnetic field and transfer energy to it. In a non-coherent field, α = β should hold, where α denotes the kinetic constant of absorption and β that of stimulated emission. This assumption is indispensable for deriving the radiation law from his model. In this context, it is problematic that a certain degree of field coherence follows necessarily from his model, which implies that αβ. Moreover, the model cannot readily be generalised to fields of arbitrary coherence. An alternative model for the absorption and emission of radiation by matter is therefore developed here. On the one hand, it is based on the assumption that, within a blackbody, quanta of different energies may recombine freely; on the other hand, it employs the “pairwise interference model of quantum theory” (PIMOQ). The alternative model of the interaction between light and matter allows the radiation law to be derived for thermal equilibrium in a non-coherent field, under which conditions, according to the model, no stimulated emissions occur. It also describes the behaviour of systems with a coherent field (interference experiment, laser). Furthermore, considerations are presented regarding the energy distribution within a blackbody and the explanatory scope of A. Einstein’s model in this respect.

Article
Biology and Life Sciences
Aquatic Science

Tommy Cueva

,

Ana González-Martínez

,

Eva Boyer

,

Cecilio Barba

,

Anton García

Abstract: Aquaculture plays a strategic role in food security and rural development in coastal regions. However, structural, economic, and institutional constraints affect small-scale producers in heterogeneous ways. This study analyzes how small-scale aquaculture producers in Manabí (Ecuador) perceive the main challenges affecting their activity, based on a typology comprising three production systems: Backyard, Transitional, and Commercial. A structured questionnaire was administered to 98 producers, including 20 variables assessed using a five-point Likert scale. The analysis combined non-parametric univariate tests (Kruskal–Wallis with Dunn post-hoc comparisons) and multivariate techniques to identify statistically significant differences and structured perception patterns across production systems. Significant differences were detected in variables related to biological input supply, market conditions, and structural production constraints. In particular, larvae and fingerling supply, selling prices, buyer availability, and pond surface area showed differentiated perception patterns across systems. Most differences occurred between Backyard farms and the other two production systems, while Transitional and Commercial farms displayed more similar perception profiles. Transversal constraints shared across systems included high feed costs, energy expenditure, and regulatory requirements. Principal Component Analysis identified two main perception gradients related to market and input constraints and to structural and managerial limitations. Discriminant analysis further confirmed the ability of these dimensions to differentiate production systems. These findings highlight the multidimensional nature of constraints affecting small-scale aquaculture and suggest that production systems are better interpreted as gradients of pressures rather than strictly discrete categories. The results underline the need for adaptive governance approaches combining transversal measures with system-specific interventions. Overall, the study provides empirical evidence to support the design of differentiated and context-sensitive policies aimed at strengthening the sustainable development of small-scale aquaculture in Manabí and similar territories.

Article
Biology and Life Sciences
Life Sciences

Laura Gramantieri

,

Clara Vianello

,

Ilaria Leoni

,

Giuseppe Galvani

,

Elisa Monti

,

Marco Bella

,

Giorgia Marisi

,

Irene Salamon

,

Manuela Ferracin

,

Gloria Ravegnini

+11 authors

Abstract: Transarterial chemoembolization (TACE) is the standard treatment for patients with intermediate-stage hepatocellular carcinoma (HCC), yet nearly half of treated patients fail to achieve durable benefit, and reliable biomarkers enabling early therapeutic stratification are still lacking. Treatment response is typically assessed by imaging one month after TACE and at three-month intervals, potentially delaying timely access to alternative therapies in non-responding patients. Circulating microRNAs (miRNAs) represent promising biomarkers due to their stability in body fluids and ease of detection. Here, we evaluated circulating miR-22 as an early predictor of TACE response and as a mechanistically relevant therapeutic target. Circulating miR-22 levels were measured by microarray and quantitative RT–PCR in three independent cohorts of early-to-intermediate stage HCC patients undergoing TACE. Circulating miR-22 increased significantly in non-responders as early as 48 h after treatment, and fold changes consistently predicted treatment failure across two independent validation cohorts. Mechanistically, we identified the G2/M checkpoint kinase WEE1 as a direct functional target of miR-22. Modulation of the miR-22/WEE1 axis affected cell-cycle progression, proliferation, apoptosis, and DNA damage response in HCC cell lines and xenograft models. Under hypoxia-mimicking conditions combined with doxorubicin exposure, pharmacological inhibition of WEE1 induced mitotic catastrophe in highly proliferative miR-22–silenced cells. Collectively, these findings identify early post-TACE elevation of circulating miR-22 as a biomarker of non-response and highlight the miR-22/WEE1 axis as a potential target for precision treatment strategies in HCC.

Article
Public Health and Healthcare
Other

Theara Teng

,

Sarin Neang

,

Bruno M. Ghersi

,

Cora Cunningham

,

Daniel Nguyen

,

Felicia B. Nutter

,

Veasna Duong

,

Thavry Hoem

,

Sothyra Tum

,

Theary Ren

+7 authors

Abstract:

In Cambodia, farmers construct artificial household bat roosts to collect and sell guano as fertilizer. We investigated farming practices and attendant spillover risks using: 1) surveys on guano production; 2) estimating bat population size and species present using carcasses, visual identification, and audio recordings; 3) surveying guano-producing and neighbor households on water, sanitation, and hygiene practices; and 4) testing guano and household food, water and surfaces for coronaviruses by PCR. Bat roosts are constructed using dried palm leaves with coconut tree and/or steel/concrete supports. Roosting areas ranged from 42-327 m2, bat abundance varied from 0-11,187, guano production was 5-120 kg/week, guano yields were 0.15-0.4 kg/m2/week, and farmers earned ~100-200 USD/household/month. Higher guano production in peak (normally wet) season was associated with greater bat abundance (p=0.016). The lesser Asiatic yellow house bat (Scotophilus kuhlii) was the only bat species identified. Roosts were <20 m from guano-producing households. Neighbors and households’ hygiene risks included not having handwashing stations and not covering food in storage/while drying. Alphacoronaviruses or Infectious Bronchitis Virus were found in 14.6%, 17.3%, 2.9%, 1.4%, and 0.0% of guano, urine, surface, food, and water samples, respectively. While guano farming offers economic benefits, spillover risks exist. Safe guano collection and storage, handwashing, and food covering in guano-producing communities are necessary to mitigate spillover risks.

Article
Engineering
Control and Systems Engineering

Basker Palaniswamy

Abstract: We pose the Typhoon Engulfment Grand Challenge: determine whether any physically realizable feedback control law can guarantee the safe flight and landing of a commercial aircraft under all extreme, physically admissible typhoon wind fields—or prove that such a guarantee is mathematically impossible. The problem is formulated as a two-player zero-sum differential game between an autopilot (the minimizer, seeking survival) and an adversarial but physics-constrained typhoon (the maximizer, seeking to force the aircraft outside its safe operating envelope). We detail the coupled nonlinear dynamics, define the safe operating set in the airspeed–load-factor plane, and identify four interlocking barriers—high-dimensional Hamilton–Jacobi–Isaacs equations, PDE-constrained adversarial disturbances, hybrid structural failure dynamics, and imperfect observations—that place this problem beyond the reach of any existing mathematical framework. This article serves as a formal statement of the challenge, provides accessible explanations for researchers across disciplines, and charts concrete research directions for communities spanning control theory, aerospace engineering, applied mathematics, machine learning, fluid dynamics, structural mechanics, formal verification, operations research, signal processing, meteorology, and independent researchers worldwide.

Article
Biology and Life Sciences
Agricultural Science and Agronomy

Hilmi Kara

Abstract:

The green peach aphid, Myzus persicae (Sulzer), is a globally important agricultural pest whose management is increasingly challenged by widespread insecticide resistance, prompting interest in alternative and sustainable control strategies such as endophytic fungi. This study evaluated the effects of two endophytic fungi, Trichoderma harzianum and Chaetomium cupreum, applied individually or as a 1:1 mixture, on the population ecology of M. persicae feeding on capia-type red pepper (Capsicum annuum L.). Aphid development, survival, and reproduction were assessed using age-stage, two-sex life table analysis. Contrary to expectations, T. harzianum significantly enhanced aphid population growth, resulting in a higher intrinsic rate of increase (r = 0.42 d-1), finite rate of increase (λ = 1.52 d-1), and net reproductive rate (R0 = 87.67 offspring) compared to the control (r = 0.32 d-1, λ = 1.37 d-1, R0 = 42.90 offspring). The mixture treatment also increased population parameters, whereas C. cupreum showed limited effects on aphid life table traits. Population projections indicated that T. harzianum treatment could produce aphid populations approximately 380 times larger than the control after 60 days. These results suggest that T. harzianum may improve host plant quality in ways that indirectly favor M. persicae. The findings highlight the importance of evaluating plant–fungus–herbivore interactions before incorporating endophytic fungi into integrated pest management programs.

Article
Computer Science and Mathematics
Artificial Intelligence and Machine Learning

Mengzhou Wu

,

Yuzhe Guo

,

Yuan Cao

,

Haochuan Lu

,

Songhe Zhu

,

Pingzhe Qu

,

Xin Chen

,

Kang Qin

,

Zhongpu Wang

,

Xiaode Zhang

+9 authors

Abstract: Scaling generalist GUI agents is hindered by the data scalability bottleneck of expensive human demonstrations and the ``distillation ceiling'' of synthetic teacher supervision. To transcend these limitations, we propose UI-Oceanus, a framework that shifts the learning focus from mimicking high-level trajectories to mastering interaction physics via ground-truth environmental feedback. Through a systematic investigation of self-supervised objectives, we identify that forward dynamics, defined as the generative prediction of future interface states, acts as the primary driver for scalability and significantly outweighs inverse inference. UI-Oceanus leverages this insight by converting low-cost autonomous exploration, which is verified directly by system execution, into high-density generative supervision to construct a robust internal world model. Experimental evaluations across a series of models demonstrate the decisive superiority of our approach: models utilizing Continual Pre-Training (CPT) on synthetic dynamics outperform non-CPT baselines with an average success rate improvement of 7% on offline benchmarks, which amplifies to a 16.8% gain in real-world online navigation. Furthermore, we observe that navigation performance scales with synthetic data volume. These results confirm that grounding agents in forward predictive modeling offers a superior pathway to scalable GUI automation with robust cross-domain adaptability and compositional generalization.

Hypothesis
Social Sciences
Education

Chathuni Sathsarani Rathnayake Weerakoon

,

Syed Tahir Abbas

Abstract: The present study examines the effects of ICT education on the competency development of 600 trainee teachers in Sri Lanka's National Institutes of Education (NIE). With respect to ICT tools and their interfaces in relation to digital literacy, teaching, and overall facilitator effectiveness, the author presents a discrete quantitative, cross-sectional ICT study. The sample was made up of 300 teachers educated in ICT and 300 teachers educated in traditional (non-ICT) methods. The study utilized a self-administered questionnaire. The author applied and described ICT, regression, and correlation analyses and integrated the ICT variable with effectiveness and competency development in Sri Lanka. The author observed that ICT educators had a higher self-efficacy and ICT tool usage and demonstrated improvements in digital literacy and pedagogy compared to non-ICT educators. A lack of integration of supplemental education technology to support teaching baseline ICT competencies was noted. A holistic approach to teacher training was advocated based on the integrated train of constructivist learning theory and TPACK framework. This study advances the empirical support of ICT and its contribution to the Sustainable Development Goal (SDG) 4, Quality Education, by demonstrating the increased value of educator competencies. The study offers actionable insights to enhance ICT training within the teacher education curricula in Sri Lanka, with the aim of equipping teachers to tackle the challenges of the digital era.

Article
Computer Science and Mathematics
Computer Vision and Graphics

Dana El-Rushaidat

,

Nour Almohammad

,

Raine Yeh

,

Kinda Fayyad

Abstract: This paper addresses the critical communication barrier experienced by deaf and hearing-impaired individuals in the Arab world through the development of an affordable, video-based Arabic Sign Language (ArSL) recognition system. Designed for broad accessibility, the system eliminates specialized hardware by leveraging standard mobile or laptop cameras. Our methodology employs Mediapipe for real-time extraction of hand, face, and pose landmarks from video streams. These anatomical features are then processed by a hybrid deep learning model integrating Convolutional Neural Networks (CNNs) and Recurrent Neural Networks (RNNs), specifically Bidirectional Long Short-Term Memory (BiLSTM) layers. The CNN component captures spatial features, such as intricate hand shapes and body movements, within individual frames. Concurrently, BiLSTMs model long-term temporal dependencies and motion trajectories across consecutive frames. This integrated CNN-BiLSTM architecture is critical for generating a comprehensive spatiotemporal representation, enabling accurate differentiation of complex signs where meaning relies on both static gestures and dynamic transitions, thus preventing misclassification that CNN-only or RNN-only models would incur. Rigorously evaluated on the author-created JUST-SL dataset and the publicly available KArSL dataset, the system achieved 96% overall accuracy for JUST-SL and an impressive 99% for KArSL. These results demonstrate the system’s superior accuracy compared to previous research, particularly for recognizing full Arabic words, thereby significantly enhancing communication accessibility for the deaf and hearing-impaired community.

Article
Biology and Life Sciences
Animal Science, Veterinary Science and Zoology

Luis Rodrigo Saa

,

Jorge Luis Armijos

,

Luisa Daniela Espinosa

,

Victor Pablo Romero

,

Alfonso Carbonero Martinez

Abstract: Brucellosis is an important infectious disease affecting livestock worldwide, causing reproductive losses in small ruminant production systems and representing a persistent challenge for animal health and public health under a One Health perspective. Despite its importance, epidemiological information on ovine brucellosis in Ecuador remains scarce. This cross-sectional study aimed to estimate the seroprevalence of Brucella spp. infection in sheep at both the individual and herd levels and to identify potential risk factors associated with infection. This study represents the largest epidemiological investigation conducted to date on ovine brucellosis in Ecuador, covering the main sheep-producing regions of the country (more than 95% of the national sheep population). Between 2024 and 2025, a total of 970 sheep from 385 farms were sampled. Serum samples were analyzed using a commercial ELISA assay, and epidemiological information was obtained through structured farm surveys. Statistical analyses included bivariate tests and a multivariable model using Generalized Estimating Equations (GEE). The overall individual seroprevalence was 5.1% (49/970), while herd-level prevalence reached 7.5% (29/385). Multivariable analysis identified abortion rate (OR = 1.045; 95% CI: 1.016–1.074) and isolation of sick animals (OR = 2.843; 95% CI: 1.150–7.027) as factors associated with seropositivity, whereas access to technical advisory services was identified as a protective factor. These findings provide essential epidemiological evidence to support surveillance programs and improve biosecurity and veterinary extension strategies in Ecuadorian sheep production systems.

Review
Medicine and Pharmacology
Dentistry and Oral Surgery

Zhao Yang

Abstract: Background:Transcrestal maxillary sinus floor elevation (TSFE) is a key technique for posterior maxillary bone deficiency in implantology, with sinus membrane perforation as the main complication. Accurate risk assessment is critical for improving surgical success and implant survival rates. Findings:TSFE surgical risk is determined by six core factors: bone defect type, elevation height, sinus floor morphology, sinus membrane status, ostium patency, and immediate implant placement. Surgical difficulty can be stratified into Easy/Moderate/Difficult, with matching technical strategies to reduce risks. Conclusions: and RelevanceMultidimensional risk stratification and targeted technique selection effectively control TSFE risks. Surgeons with lateral window technique experience are recommended for TSFE, and multidisciplinary collaboration is advised for high-difficulty cases, providing precise guidance for clinical implant practice.

Article
Chemistry and Materials Science
Materials Science and Technology

Alexander Haynack

,

Thomas Kränkel

,

Christoph Gehlen

,

Jithender J. Timothy

Abstract: This study presents a distribution-optimized mesostructure estimation method for modeling near-surface aggregate size distributions in concrete by optimizing the spatial arrangement of polydisperse spherical aggregates with respect to formwork boundaries. The approach is based on minimizing the deviation between a generated cumulative aggregate volume function and an idealized linear target function corresponding to a constant area fraction along the specimen depth. To enable efficient computation for systems containing a large number of aggregates, grain size classes derived from the grading curve are represented using symmetric Beta distributions, allowing each group to be described by a single shape parameter. The resulting optimization problem is solved using a derivative-free Powell algorithm. The method inherently captures wall effects, leading to a migration of smaller aggregates toward the specimen boundaries to compensate for geometric constraints of bigger aggregates. Experimental validation was performed by determining the depth-dependent mean bulk density of a concrete cube using incremental surface grinding combined with high-resolution 3D laser scanning. The optimized mesostructure shows strong agreement with measured density profiles, significantly improving over a non-optimized distribution. Furthermore, increasing aggregate volume fractions intensify near-surface accumulation of fine particles. The proposed method provides a computationally efficient framework for incorporating wall effects into mesoscale concrete models.

Article
Medicine and Pharmacology
Anesthesiology and Pain Medicine

Wojciech Danysz

,

Paulina Nunez-Badinez

,

Andreas Gravius

,

Klaus Fink

,

Jens Nagel

Abstract:

Background/Objectives: Trigeminal neuralgia (TN) is a debilitating neurological condition characterized by recurrent, severe pain linked to peripheral and central sensitization within trigeminal pathways. Although current pharmacologic treatments are limited by inadequate efficacy or dose-limiting side effects, botulinum neurotoxin type A (BoNT/A) has emerged as a viable option. However, its potential use in the management of TN is hampered by methodological limitations in existing studies and a lack of pivotal clinical trials. This study investigated the efficacy, optimal treatment site, preventive utility, and duration of effect of incobotulinumtoxinA (Inco/A), a BoNT/A, in a model of TN. Methods: An infraorbital nerve chronic constriction injury model was used to induce mechanical allodynia in male Sprague–Dawley rats, reproducing the trigeminal sensitization seen in TN. The effects of subcutaneous Inco/A (1, 2, and 4U) were measured using the mechanical sensitivity (von Frey) test to evaluate the dose response, effect of injection location, potential preventive nature of treatment, and duration of benefit. Results: Inco/A produced a robust, dose-dependent reduction in mechanical allodynia, predominantly via a local mechanism of action. Both preventive and therapeutic administration of Inco/A was efficacious, with significant reduction of allodynia even when administered up to 28 days before nerve injury. The anti-allodynic effect persisted up to 56 days post-injection. Conclusions: Inco/A is highly effective in alleviating mechanical allodynia in a validated rat model of TN. The findings highlight Inco/A as a promising candidate for clinical translation in TN and related neuropathic pain syndromes and support systematic investigation in well-controlled human trials.

Article
Business, Economics and Management
Finance

Pedro Sobreiro

,

Domingos Martinho

,

Rui Martins

,

Ricardo Vardasca

Abstract: Predicting profitable entry signals in Bitcoin markets remains challenging due to price volatility, the absence of fundamental valuation frameworks, and methodological pitfalls that are common in the literature. In this study, we evaluate five machine learning classifiers using a 37-feature hierarchical multi-timeframe pipeline with price-level-agnostic normalisation across four temporal resolutions (15-minute, 4-hour, daily, and 3-day), spanning January 2020 to November 2025. Binary training labels were generated via majority-vote aggregation across 54 stop-loss/take-profit combinations, producing 6,951 balanced samples (48.5% positive class). Five algorithms --- Logistic Regression, Decision Tree, Random Forest, XGBoost, and LightGBM --- are compared using expanding-window TimeSeriesSplit validation (5 folds). Random Forest achieved the highest cross-validated ROC-AUC (0.6086), with all models showing modest but consistent discriminative ability (range 0.57--0.61). Feature importance analysis identifies 4-hour Bollinger Band position and RSI as dominant predictors, with all timeframes contributing meaningfully. A true out-of-sample holdout on 1,136 independently generated 2025 samples confirms generalisation, with Logistic Regression achieving 0.6087 ROC-AUC. A subtle multi-timeframe look-ahead bias in higher-timeframe data alignment is identified and corrected, which inflated performance by approximately 0.20 ROC-AUC points before correction. Event-driven backtesting on 2025 out-of-sample data yields a gross upper-bound return of +35.97% (185 trades, SL=1%, TP=2%, threshold=0.7, Sharpe=0.14) before transaction costs; after realistic round-trip fees, net returns are likely negligible. The central finding is that models with ROC-AUC $\approx$ 0.60 cannot reliably generate economically significant returns once transaction costs are accounted for. The methodology provides a reproducible framework for ML-based binary classification studies requiring transparent, bias-corrected validation across diverse market regimes.

Article
Environmental and Earth Sciences
Water Science and Technology

Herbert O. Misiani

,

Betty N. Barasa

,

Franklin Joseph Opijah

,

Hussen S. Endris

,

Jully O. Ouma

,

Christopher Lennard

Abstract: This study evaluates the potential of solar radiation management (SRM) to mitigate projected increases in rainfall and flood risk across four major urban centers in Eastern Africa. Flood dynamics under historical and future climate conditions were simulated using the Rainfall–Runoff–Inundation (RRI) model. Observed hydrological conditions were established using daily precipitation from the Climate Hazards Group Infrared Precipitation with Stations (CHIRPS), together with hydrological and topographic datasets. Future flood projections and associated impacts were derived from climate simulations produced by the Whole Atmosphere Community Climate Model version 6 (WACCM6) and solar climate intervention experiments from the Assessing Responses and Impacts of Solar climate intervention on the Earth system with Stratospheric Aerosol Injection (ARISE-SAI) framework, both forced by the Shared Socioeconomic Pathway SSP2-4.5. Model performance was evaluated using the Nash–Sutcliffe efficiency (NSE), coefficient of determination (R2), root mean square deviation (RMSD), and peak discharge error (PDE). The RRI model reproduced observed river discharge with reasonable skill, exhibiting lower RMSD and PDE values for the Ethiopian catchment compared to those in Kenya and Tanzania. Results indicate that SRM implemented through stratospheric aerosol injection (SAI) can reduce peak inundation depths and the spatial extent of flooding in selected flood-prone areas of Dar es Salaam and Addis Ababa. These reductions correspond to a decrease in the projected exposure of populations and critical infrastructure to flood hazards. While the findings suggest that albedo-based solar geoengineering may moderate flood impacts in some Eastern African cities, uncertainties remain, particularly in the representation of convective rainfall processes and the reliance on a single hydrological modeling framework in this study. Further research using improved climate simulations and ensemble-based hydrological approaches is recommended.

Article
Computer Science and Mathematics
Artificial Intelligence and Machine Learning

Taehyeon Kim

,

Hangyeol Lee

,

Chang Wook Ahn

,

Man-Je Kim

Abstract: Recent progress in text-to-music generation has enabled high-quality audio synthesis from natural language prompts. However, such models are at risk of unintended replication, raising concerns regarding originality and intellectual property. While training-time mitigation strategies can address this issue, they typically require retraining or curated datasets, limiting their practicality for largescale systems. Inference-time methods provide a more lightweight alternative but often involve a trade-off between fidelity and memorization risk. This work introduces Repulsive Guidance (RG), a systematic inference-time mitigation strategy that reduces memorization without disrupting the intended conditional guidance from the text prompt. RG operates by enforcing divergence between dual diffusion trajectories through a repulsive term applied only during early denoising steps, without reversing the conditional guidance from the prompt. Experiments on MusicBench with the TANGO model demonstrate that RG offers a complementary mitigation strategy, providing new insights into balancing fidelity and memorization risk.

Article
Business, Economics and Management
Economics

Simo Sun

,

Yuandong Wang

,

Jianjun Jiao

,

Yadong Shu

Abstract: Based on the principal-agent theory, this paper constructs a n-level principal-agent model with multi-branches at the chain terminal, introduces the improved Fehr-Schmidt fairness preference theory, and establishes a n-level incentive framework covering the horizontal and vertical fairness preferences of terminal agents. By treating intermediate agents as a unified whole through the "black-box" approach, this paper focuses on analyzing the influence mechanism of terminal agents' fairness preferences on effort level, incentive contract design and the operational efficiency of the entire principal-agent chain. The research results confirm that incorporating fairness preferences into the incentive mechanism design of green supply chain principal-agent relationships can effectively stimulate the production and operation enthusiasm of terminal agents, improve their effort levels; at the same time, it can significantly reduce agency costs in the principal-agent chain, optimize resource allocation efficiency, and thereby enhance green production efficiency. The conclusions and model design of this study provide a new theoretical path and practical reference for the collaborative operation and sustainable development of actual green supply chains with terminal multi-branch principal-agent structures.

Article
Social Sciences
Cognitive Science

Shoko Miyano

,

Takashi Shiono

Abstract: Chaotic itinerancy—irregular switching among metastable collective states—provides a dynamical substrate for flexible social coordination, yet its mechanistic origin in multi-agent systems remains unclear. We present a multi-agent Active Inference model in which chaotic itinerancy emerges from Expected Free Energy minimization without outcome-level social priors. Agents select actions to minimize Expected Free Energy while updating preferences through a precision-gated learning mechanism modulated by interpersonal trust. Hill-function nonlinearity in state transitions creates bistable “affordance landscapes” that gate behavioral mode switching. Simulations with small number of agents on an Erdos–Rényi trust network reveal spontaneous alternation among multiple metastable behavioral clusters, heavy-tailed dwell-time distributions, and sign-changing finite-time Lyapunov exponents—three hallmarks of chaotic itinerancy. Crucially, replacing Hill-function dynamics with linear transitions reduces the chaotic-itinerancy detection rate from 80% to 20%, demonstrating that nonlinear affordance structure is necessary for generating metastable switching. We further show that agents with simplified internal models of the world sustain richer itinerant dynamics as a group than “perfect-foresight” agents, suggesting that bounded rationality may be functionally advantageous for maintaining behavioral flexibility. These results establish active inference as a principled framework for modeling chaotic itinerancy in social systems and offer a computational account of trust-mediated collective transitions observed in theatre workshops and group dynamics.

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