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Preprint ARTICLE | doi:10.20944/preprints202409.0212.v1

Dietary Patterns Correlate with Transition Readiness of Adolescents with Autism: A Pilot Study

Lilian de Jonge, Blessing Seidu

Subject: Public Health And Healthcare, Other Keywords: Adolescents with autism; Comorbidities in autism; Dietary quality of adolescents with autism; Transition to adulthood for people with autism; Cross-sectional study

Online: 4 September 2024 (04:34:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0091.v1

Enhancing Medical Tourism In Bali: A Readiness Analysis of Siloam Hospital Through Actor-Network Theory (ANT)

Ni Gusti Ayu Putri Mayuni, Ida Ayu Oka Martini

Subject: Public Health And Healthcare, Other Keywords: medical tourism; private hospitals; bali; actor-network theory; readiness; siloam hospital bali

Online: 3 September 2024 (03:33:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202409.0122.v1

Self-reported Physical Activity Levels, Leisure-time Physical Activity Preferences and Frequency of Non-Sedentary Behaviors: Comparative Study between Portuguese, Italian and Spanish Students Attending Higher Education

Rui Miguel Paulo, André Ramalho, Isabella Scursatone, Maria Caire, Nicolás Bores Calle, Daniel Bores-García, María Espada, Miguel Rebelo, Pedro Duarte-Mendes

Subject: Public Health And Healthcare, Other Keywords: Higher education students; sedentary lifestyle; physical activity; health.

Online: 2 September 2024 (23:27:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0466.v2

Histological Findings In Prosthetic Valve Endocarditis – A Retrospective Cohort Study Conducted at "Dr. Carol Davila" Central Military Emergency University Hospital in Bucharest

CORINA IOANA ANTON, SORIN DUȚULESCU, Florica Staniceanu, Cosmin Alexandru Buzilă, Alexia Teodora Ștefan, Ion Ștefan, Adrian Streinu-Cercel

Subject: Public Health And Healthcare, Other Keywords: infective endocarditis; prosthetic valve endocarditis; mitral valve; aortic valve; histopathology

Online: 30 August 2024 (23:40:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.2052.v1

Could Exposure to SARS-CoV-2 Be a Risk Factor for Alterations in Functional Vision Parameters in Infants?: A Cross-sectional Study

Giovana Rodovanski, Victor Costa, Marcelo Costa, Antonio Carlos Sobieranski, Cristiane Moran

Subject: Public Health And Healthcare, Other Keywords: Children; COVID-19; Pregnant women; SARS-CoV-2; Vision

Online: 29 August 2024 (16:46:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1995.v1

Bacterial and Viral Co-Infections in COVID-19 Patients: Etiology and Clinical Impact

Iveta Rumenova Madzharova, Ivelina Trifonova, Neli Stoyanova Korsun, Viktoria Levterova, Petar Velikov, Silvya Voleva, Ivan Ivanov, Daniel Ivanov, Ralitsa Yordanova, Tatiana Tcherveniakova, Svetla Angelova, Iva Christova

Subject: Public Health And Healthcare, Other Keywords: SARS-CoV-2; co-infection; respiratory viruses; Haemophilus influenzae; RSV

Online: 28 August 2024 (05:13:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1912.v1

Intratumoral Microbes in Oral Squamous Cell Carcinoma: Focus on Treponema denticola, Lactobacillus casei, and Candida albicans

Yeon-Hee Lee, Junho Jung, Ji-Youn Hong

Subject: Public Health And Healthcare, Other Keywords: microbiome; oral squamous cell carcinoma; bacteria; fungi; Candida albicans; oral cancer

Online: 27 August 2024 (11:12:01 CEST)

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In this study, we aimed to explore the oral bacteria and fungi that can help discern oral squamous cell carcinoma (OSCC) and investigate the correlations between multiple key pathogens. Methods: Twelve participants (8 females and 4 males; mean age, 54.33 ± 20.65 years) were prospectively recruited into three groups: Group 1: healthy control, Group 2: patients with stomatitis, and Group 3: patients with OSCC, with 4 individuals in each group. Unstimulated whole saliva samples from these participants were analyzed using real-time PCR to assess the presence and abundance of 14 major oral bacterial species and Candida albicans. Results: The analysis revealed significant differences for certain microorganisms, namely Treponema denticola (T. denticola), Lactobacillus casei (L. casei), and Candida albicans. T. denticola was most abundant in the OSCC group (5,358,692.95 ± 3,540,767.33), compared to the stomatitis (123,355.54 ± 197,490.86) and healthy control (9,999.21 ± 11,998.40) groups. L. casei was undetectable in the healthy control group, but was significantly more abundant in the stomatitis group (1,653.94 ± 2,981.98) and even higher in the OSCC group (21,336.95 ± 9,258.79) (p = 0.001). A similar trend was observed for C. albicans, with DNA copy numbers rising from the healthy control (464.29 ± 716.76) to the stomatitis (1,861.30 ± 1,206.15) to the OSCC group (9,347.98 ± 5,128.54) (p = 0.006). The amount of T. denticola was positively correlated with L. casei (r=0.890, p<0.001) and C. albicans (r=0.724, p=0.008). L. casei's DNA copy number was strongly correlated with C. albicans (r=0.931, p<0.001). These three oral microbes exhibited strong positive correlations with each other and had various direct or indirect relationships with other species. Conclusions: In the OSCC group, T. denticola, L. casei, and C. albicans exhibited strong positive correlations with one another, further emphasizing the need for a deeper understanding of the complex microbial interactions in the OSCC environment.

Preprint ARTICLE | doi:10.20944/preprints202408.1323.v2

Soft Sets Extensions: Innovating Healthcare Claims Analysis

Daniela Gifu, Florentin Smarandache

Subject: Public Health And Healthcare, Other Keywords: soft sets; healthcare data analysis; HyperSoft Sets; data modeling; healthcare claims data; decision-making; advanced data methodologies

Online: 22 August 2024 (15:16:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1577.v1

Structure of Spectral Composition and Synchronization in Human Sleep on the Whole Scalp: A Pilot Study

Jesus Pastor Pastor, Paula Garrido Zabala, Lorena Vega-Zelaya

Subject: Public Health And Healthcare, Other Keywords: bipolar montage; coherence; fast Fourier transform; K-complex; Pearson’s correlation coefficient; Polysomnography; power spectra; qEEG; sleep spindles; sleep staging.

Online: 21 August 2024 (14:28:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1469.v1

Radiological Changes in Spinal Cord and Brain of Patients with HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP)

Emily H Stack, Serhat V Okar, Tianxia Wu, Mallory Stack, Yair Mina, Maria I Gaitan, Shila Azodi, William Frazier, Joan Ohayon, Irene Cortese, Daniel S. Reich, Govind Nair, Steven Jacobson

Subject: Public Health And Healthcare, Other Keywords: central nervous system atrophy; spinal cord atrophy; white matter hyperintensities; magnetic resonance imaging; HTLV-1-associated myelopathy

Online: 21 August 2024 (10:16:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1359.v1

Preparing the Future Public Health Workforce: Integrating Relational Employability to Foster Critical Global Citizenship

Elizabeth J Cook, Sally-Anne Doherty, Ruth Wallace

Subject: Public Health And Healthcare, Other Keywords: Relational employability; global citizenship; public health education; research skills development; critical reflective practice; higher education curriculum; health workforce development; global competence; qualitative research

Online: 20 August 2024 (12:09:13 CEST)

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A well-prepared public health workforce is essential for reducing disease burdens and improving population health, requiring an education that addresses global and complex challenges. This paper examines the integration of the relational employability framework in public health education to cultivate critical global citizenship among students and graduates. Our research, conducted at Edith Cowan University in Perth, Western Australia, involved two case studies using qualitative interviews. Case Study 1, drawn from Cook’s doctoral research, explored student experiences with the relational employability framework within an undergraduate capstone unit. Case Study 2, a school-funded project, gathered graduate perspectives to inform ongoing curriculum development. The findings indicate that the relational employability framework enhances global competencies among students and graduates, through research skills development and critical reflective practice. Students reported improved awareness of their learning needs, self-confidence, and an increased ability to engage with diverse perspectives and societal challenges. Graduates highlighted the framework’s role in understanding ethical standards, conducting rigorous research and applying evidence-based practices in professional settings. Additionally, the framework supported the development of a reflective mindset, enabling graduates to make informed, value-based career decisions and advance their professional growth. The study suggests that adopting a relational employability approach can effectively prepare globally competent and reflective public health professionals. We advocate for the broader implementation of this framework in health education and higher education, offering practical recommendations for curriculum transformation. Such an approach will equip future professionals to contribute meaningfully to public health debates and embody the principles of global citizenship in their practice.

Preprint ARTICLE | doi:10.20944/preprints202408.1323.v1

Soft Sets Extensions: Innovating Healthcare Claims Analysis

Daniela Gifu

Subject: Public Health And Healthcare, Other Keywords: Soft Sets; Healthcare Data Analysis; HyperSoft Sets; Data Modeling; Healthcare Claims Data; Decision-Making; Advanced Data Methodologies

Online: 19 August 2024 (10:38:07 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202408.1119.v1

De Novo Assembly of H3L and A17L Epitopes for the Rapid Development of Clade 1b MPOX Countermeasures for Africa

Misaki Wayengera

Subject: Public Health And Healthcare, Other Keywords: MPox; MPXV; H3L; A17L; Medical Countermeasures; Vaccines; Diagnostics; Therapeutics

Online: 15 August 2024 (16:32:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.1015.v1

EfficientUNetViT: Efficient Breast Tumor Segmentation utilizing U-Net Architecture and Pretrained Vision Transformer

Shokofeh Anari, Gabriel Gomes de Oliveira, Ramin Ranjbarzadeh, Angela Maria Alves, Gabriel Caumo Vaz, Malika Bendechache

Subject: Public Health And Healthcare, Other Keywords: Breast cancer; Unet; Vision transformer; Depthwise Separable Convolutional

Online: 14 August 2024 (08:20:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0666.v1

Succeeding in Difficult Conversations: Evaluating Motivational Interviewing Teaching Techniques Through the Lens of Vaccine Hesitancy

Alec Harrington, Kayla Lauffer, Luke Twenhafel, Anicka Gajar, Kyle Wansing, Aleesa Rosas, Erika Wicher, Sharon Ke, William Kang, Gianna Tarka, Isain Zapata, Benjamin Brooks

Subject: Public Health And Healthcare, Other Keywords: Vaccine hesitancy; motivational interviewing; medical education; teaching methods; clinical communication

Online: 9 August 2024 (12:10:20 CEST)

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Background: Vaccine hesitancy, identified by the World Health Organization as a top ten global health threat, presents a significant barrier to public health efforts, exacerbated by the politicization of vaccines during the COVID-19 pandemic.1 Motivational interviewing (MI) has been shown to be effective in addressing difficult topics, including vaccine hesitancy, emphasizing the need for its integration into medical education.2 Objective: This study explores ways to enhance the medical student curriculum on MI, specifically targeting the management of conversations with vaccine-hesitant patients. These authors seek to evaluate the impact of different teaching approaches on the efficacy of MI training within clinical education. Methods: A blinded study design was implemented, comparing two groups of medical students trained using distinct MI teaching methods: Learning Through Experience (LTE) and Traditional Teaching (TT). The LTE group engaged with a Vaccine Hesitant Standardized Patient (VHSP) before and after an instructional module on the use of MI to combat vaccine hesitancy. In contrast, the TT group interacted with a control Standardized Patient (SP) before the same module and then with the VHSP. Any medical student above the age of 18 was eligible for this study. All students in a vaccine elective at RVUCOM on the Colorado and Utah campuses were enrolled, as well as student volunteers. We excluded any students who opted out of the study. The effectiveness of each method was assessed through confidence and performance scores derived from participant self-evaluations and standardized patient feedback, respectively. Results: Participants in the TT group demonstrated superior mastery of MI skills as taught in the didactic session based on statistically significant findings across more tested variables. The LTE group exhibited enhanced ability in practical applications with standardized patients based on statistically significant findings. Both groups showed increased confidence in MI techniques, with the LTE group reporting greater confidence in vaccine knowledge and MI abilities. That said, the LTE method did not drastically outperform the TT approach in overall efficacy. Conclusions: The study indicates that while traditional TT training effectively imparts MI skills, the LTE approach may offer benefits in applying these skills in clinical scenarios. These findings suggest the potential for integrating multiple teaching methods into the medical curriculum to better prepare students for engaging with vaccine-hesitant patients. Further research is needed to explore the long-term effects of these teaching strategies on student performance and patient outcomes.

Preprint ARTICLE | doi:10.20944/preprints202408.0466.v1

Histological Findings In Prosthetic Valve Endocarditis – A Retrospective Cohort Study Conducted at "Dr. Carol Davila" Central Military Emergency University Hospital in Bucharest

CORINA IOANA ANTON, SORIN DUȚULESCU, Florica Staniceanu, Cosmin Alexandru Buzilă, Alexia Teodora Ștefan, Ion Ștefan, Adrian Streinu-Cercel

Subject: Public Health And Healthcare, Other Keywords: infective endocarditis; prosthetic valve endocarditis; mitral valve; aortic valve; histopathology

Online: 7 August 2024 (09:09:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0435.v1

Measuring Stress in Later Adulthood: Examining the Psychometric Properties of the Revised Stress Assessment Inventory for Older Adults

Rhiannon Y. Ueberholz, Lauren Hytman, Carmen Dang, Alexandra Jasmine Fiocco

Subject: Public Health And Healthcare, Other Keywords: stress measurement; healthy aging; older adults; stress-related illness

Online: 6 August 2024 (15:57:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0283.v1

Choline and Essential Fatty Acids Inadequate Intake in Latin American Childbearing Age Women as a Regional Pre‐Conceptional Disadvantage. ELANS Results

Marianella Herrera-Cuenca, Martha Cecilia Yépez García, Lilia Yadira Cortés Sanabria, Pablo Hernandez, Guillermo Ramírez, Maura Vásquez, Yaritza Sifontes, Georgina Gómez, María Reyna Liria-Domínguez, Attilio Rigotti, Mauro Fisberg, Irina Kovalskys, Maritza Landaeta-Jimenez

Subject: Public Health And Healthcare, Other Keywords: choline; essential fatty acids; women of childbearing age; diet; Latin America; ELANS; dietary intake

Online: 5 August 2024 (14:17:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0278.v1

Health Literacy: Structural Topic Modeling and Citation Trends

Benjamin M. Tabak, Matheus Britto Froner, Rubiane Daniele C. de Almeida, Luzia Cláudia D. Couto, Thiago Christiano Silva, Sayonara de Fatima Faria Barbosa

Subject: Public Health And Healthcare, Other Keywords: Health Literacy; Mental Health Literacy; Digital Health Literacy; HLQ; HLS-EU; MHLS; REALM; TOFHLA; eHeals; NVS

Online: 5 August 2024 (08:27:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0212.v1

Cross-Sectional Study of the Fad Diet among Office Workers in Mongolia

Narkhajid Davaanyam, Bata Róbert

Subject: Public Health And Healthcare, Other Keywords: fad diet; diet

Online: 3 August 2024 (08:33:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2596.v1

Variable Concentration of Ferritin in Meconium in Relation to the Iron Regulatory Proteins and Newborn Body Size

Ewa Skarżyńska, Artur Jakimiuk, Tadeusz Issat, Barbara Lisowska-Myjak

Subject: Public Health And Healthcare, Other Keywords: calprotectin; ceruloplasmin; ferritin; fetus; haptoglobin; iron; lactoferrin; meconium; NGAL; transferrin

Online: 2 August 2024 (11:40:58 CEST)

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Ferritin is an indirect marker for total body iron stores. Comparison of the ferritin concentrations in the meconium with the concentrations of proteins regulating iron metabolism could aid better understanding of principles behind the adjustment between the fetal iron pool and newborn body size. Ferritin, transferrin, haptoglobin, ceruloplasmin, lactoferrin, myeloperoxidase, neutrophil gelatinase-associated lipocalin (NGAL) and calprotectin concentrations were measured by ELISA in meconium samples from 122 neonates. The neonates were classified according to the meconium ferritin tertiles and the values were collated with the meconium concentrations of other proteins and newborn body weight and length measurements. Increasing ferritin concentrations in meconium in consecutive tertiles (p < 0.05) were parallel to increased NGAL concentrations (p < 0.05). The interrelationships between the meconium concentrations of transferrin, haptoglobin and NGAL as well as between myeloperoxidase, calprotectin and lactoferrin are maintained in all subsequent tertiles of ferritin concentrations, (p < 0.05). In contrast to ferritin, increasing meconium NGAL concentrations in consecutive tertiles were linked to increased concentrations of transferrin, haptoglobin, lactoferrin and myeloperoxidase (p < 0.05) and of calprotectin, ferritin and ceruloplasmin (p < 0.1). Meconium ceruloplasmin concentrations correlate exclusively with neutrophil granule proteins, i.e. myeloperoxidase, NGAL, lactoferrin and calprotectin (p < 0.05). Meconium ferritin concentrations negatively correlates with birth weight (r= -0.20) and length (r= -0.31) of neonates, whereas NGAL concentrations just with birth length (r= -0.26). The remaining proteins did not show such relationships with the size of the newborn. High meconium concentrations of both ferritin and NGAL may specifically characterize neonates of smaller size. High meconium concentrations of both ferritin and NGAL may specifically characterize neonates with lower body measurements. Correlations between meconium transferrin, haptoglobin and NGAL may confirm the interrelationships of these proteins for proper iron control and transport in the intrauterine environment. Meconium ceruloplasmin concentrations may reflect the control of neutrophil activity in utero.

Preprint ARTICLE | doi:10.20944/preprints202408.0114.v1

Impact of Internet Use on Health Status in China: Evidence Based on A national Longitudinal Survey Data

Ma Xinxin

Subject: Public Health And Healthcare, Other Keywords: Internet use; Health status; Self-rated health; Mental health; Digital divide; China

Online: 2 August 2024 (10:22:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202408.0131.v1

Salmonella Inactivation Model by UV-C Light Treatment in Chicken Breast

Rosa María García-Gimeno*, Guiomar Denisse Posada-Izquierdo, Eva Palomo-Manzano, Poliana Mendes de Souza

Subject: Public Health And Healthcare, Other Keywords: non-thermal treatment; UV-C; low transmittance food; mathematical modelling; foodborne pathogens

Online: 2 August 2024 (06:04:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2546.v1

Dynamics of Mammarenavirus Wenzhouense Acute Infection in the Rodent Rattus norvegicus

ShanShan Du, XueFei Deng, Xiaoxia Huang, TieZhu Liu, Aqian Li, Qin Wang, TingTing Tian, Chuan Li, ZhangQi Zheng, QiHan Lin, ZhuoWei Li, Shiwen Wang, Jiandong Li

Subject: Public Health And Healthcare, Other Keywords: Wenzhou virus; acute infection; virus shedding, transmission; rodents; arenavirus

Online: 31 July 2024 (15:21:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2593.v1

Associations between Meal Patterns and Risk of Overweight/Obesity and Metabolically Unhealthy Obesity in Children and Adolescents: A Systematic Review of Longitudinal Studies and Randomised Controlled Trials

Georgios Saltaouras, Athanasia Kyrkili, Eirini Bathrellou, Michael Georgoulis, Mary Yannakoulia, Vasiliki Bountziouka, Urška Smrke, Georgios Dimitrakopoulos, Meropi D Kontogianni

Subject: Public Health And Healthcare, Other Keywords: childhood obesity; metabolically unhealthy obesity; meal patterns; breakfast; lunch; dinner; snacks; meal frequency; meal context; meal timing

Online: 31 July 2024 (15:14:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2513.v1

Chrono-Nutrition, Chrono-Type, and the Prevalence of Type 2 Diabetes Mellitus in a Cross-Sectional Study from the European Prospective Investigation into Cancer and Nutrition (EPIC) Study

Leila Luján-Barroso, Hernando J Margara-Escudero, Marta Crous-Bou, José María Huerta, Maria-Dolores Chirlaque, Esther Molina-Montes, María-José Sánchez, Marcela Guevara, Conchi Moreno-Iribas, Pilar Amiano, Olatz Mokoroa, Sonia González, Antonio Agudo, Jose Ramón Quirós, Paula Jakszyn

Subject: Public Health And Healthcare, Other Keywords: Chrono-nutrition; type 2 diabetes; meal timing; macronutrients; EPIC-Spain

Online: 31 July 2024 (11:14:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.2187.v1

The Role of Nutrition in the Pathogenesis and Treatment of Autoimmune Bullous Diseases – A Narrative Review

Aleksandra Anna Kajdas, Agnieszka Żebrowska, Anna Zalewska-Janowska, Aneta Czerwonogrodzka-Senczyna

Subject: Public Health And Healthcare, Other Keywords: autoimmune bullous diseases; nutrition; diet; pemphigus; pemphigoid; dermatitis herpetiformis; epidermolysis bullosa aqusita

Online: 29 July 2024 (02:58:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.2035.v1

Metabolite, Biochemical, and Dietary Intake Alterations Associated with Lifestyle Interventions in Obese and Overweight Women

Fatin Saparuddin, Mohd Naeem Mohd Nawi, Liyana Ahmad Zamri, Fazliana Mansor, Mohd Fairulnizal Md Noh, Mohd Azahadi Omar, Nur Shahida Abdul Aziz, Norasyikin Abdul Wahab, Ahmed Mediani, Nor Fadilah Rajab, Razinah Sharif

Subject: Public Health And Healthcare, Other Keywords: Metabolomics; NMR; metabolically healthy obese; lifestyle intervention; obesity

Online: 25 July 2024 (12:53:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1785.v1

Impact of VR-Based Cognitive Training on Working Memory and Inhibitory Control in IDD Young Adults

Maria João Trigueiro, Joana Lopes, Vítor Simões-Silva, Bruno Bastos Vieira de Melo, Raquel Simões de Almeida, António Marques

Subject: Public Health And Healthcare, Other Keywords: intellectual developmental disability; virtual reality; cognitive training; serious games; executive functions

Online: 23 July 2024 (13:36:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1761.v1

Anxiety and Associated Factors Among Chinese Preschool Teachers: A Cross-Sectional Study

Xiaohan Wang, Tinakon Wongpakaran, Pichaya Pojanapotha, Priyanut Chupradit, Kelvin C Y Leung

Subject: Public Health And Healthcare, Other Keywords: preschool teachers; anxiety; mental health; work-related stress; interpersonal difficulty; perceived stress; neuroticism; resilience; inner strength

Online: 23 July 2024 (11:35:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1756.v1

Alcohol Intake and Prevalent Kidney Stone: The National Health and Nutrition Examination Survey 2007–2018

Sandipan Shringi, Christina A. Raker, Michel Chonchol, Jie Tang

Subject: Public Health And Healthcare, Other Keywords: Alcohol intake, beer, wine, liquor, kidney stone

Online: 22 July 2024 (17:29:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1745.v1

Lassa Fever: Critical Review and Prospects for Control

Marianne E Besson, Michel Pepin, Pierre-Alexandre Metral

Subject: Public Health And Healthcare, Other Keywords: neglected tropical disease; emerging disease; zoonosis; viral haemorrhagic fever; Lassa Fever; global health

Online: 22 July 2024 (14:17:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1695.v1

Optimizing Recurrence Reduction in Central Giant Cell Granuloma: A Comparative Analysis of Treatment Modalities

Flamur Aliu, Donika Bajrami Shabani, Iliriana Aliu, Etleva Droboniku, Gerta Kaçani, Luca Fiorillo, Aida Meto

Subject: Public Health And Healthcare, Other Keywords: ; central giant cell granuloma; recurrence; treatment modalities; surgical excision; curettage; corticosteroid injection ;

Online: 22 July 2024 (09:30:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.1604.v1

Unveiling the Molecular Mechanisms of the Placenta Accreta Spectrum

Erik Lizárraga-Verdugo, Saúl Armando Beltrán-Ontiveros, Erick Paul Gutiérrez-Grijalva, Mariana Avendaño-Félix, Perla Y. Gutiérrez-Arzapalo, Karla Paola Gutiérrez-Castro, Marisol Montoya-Moreno, Daniel E. Cuén-Lazcano, Paul González-Quintero, Carlos Ernesto Mora-Palazuelos

Subject: Public Health And Healthcare, Other Keywords: placenta accreta spectrum; trophoblast invasion; placenta acreta; placenta increta; placenta percreta

Online: 19 July 2024 (11:54:51 CEST)

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Placenta accreta spectrum (PAS) disorders are characterized by abnormal trophoblastic invasion into the myometrium, leading to significant maternal health risks. PAS includes placenta accreta (invasion <50% of the myometrium), increta (invasion >50%), and percreta (invasion through the entire myometrium). The condition is most associated with previous cesarean deliveries, and its incidence increases with the number of cesareans. Other risk factors include advanced maternal age, multiparity, and various uterine surgeries. The increasing global cesarean rates heighten the importance of early PAS diagnosis and management. The study reviewed molecular mechanisms driving PAS, focusing on signaling pathways, genetic expression, biomarkers, and non-coding RNAs involved in trophoblastic invasion. It explored genetic expression and key regulatory processes such as apoptosis, cell proliferation, invasion, and inflammation. The manuscript was compiled from recent scientific literature (2014 – 2024) from the Scopus, PubMed, Google Scholar, and Web of Science databases. Placenta Acreta Spectrum; acreta; increta; percreta; trophoblast invasion; miRNAs, lncRNAs; genetic expression; biomarkers; signaling pathways were the employed keywords to compile relevant literature. The PAS is an important obstetric health problem that challenges maternal health risks associated with abnormal trophoblastic invasion that relies on abnormal placentation, uterine scarring, and impaired decidualization. Identifying new biomarkers like AFP, sFlt-1, β-hCG, PlGF, and PAPP-A aids early detection and management. Understanding genetic expression and non-coding RNAs is crucial for unraveling PAS complexities. Besides, aberrant signaling pathways like Notch, PI3K/Akt, STAT3, and TGF-β offer potential therapeutic targets to modulate trophoblastic invasion. This review underscores the need for interdisciplinary care, early diagnosis, and ongoing research into PAS biomarkers and molecular mechanisms to improve prognosis and quality of life for affected women.

Preprint ARTICLE | doi:10.20944/preprints202407.1468.v1

Working Conditions for Burns Junior Doctors – Better Now Than Ever?

Grant Coleman, Toby Austin, James Forrest, Sarah Bache

Subject: Public Health And Healthcare, Other Keywords: Junior doctors; Job satisfaction; Burns; Workload; Historical article; work-life balance; Surgical training

Online: 18 July 2024 (06:50:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1363.v1

Anti-aging Effects of Low Molecular Weight Collagen Peptides Supplementation on Facial Wrinkles and Skin Hydration: Outcomes from a Six-Week Randomized, Double-Blind, Placebo-Controlled Trial

Juan Antonio Carrillo-Norte, Baldomero García-Mir, Lluis Quintana, Bruno Buracchio, Rafael Guerrero-Bonmatty

Subject: Public Health And Healthcare, Other Keywords: low molecular weight collagen; anti-aging; skin health; facial wrinkles; moisturization; nutraceutical; randomized controlled trial

Online: 17 July 2024 (10:24:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1291.v1

Emotional Impact of COVID-19 and Emotional Eating and the Risk of Alcohol Use Disorder in Healthcare Students

Jhon Alex Zeladita-Huaman, Juan Pablo Aparco, Eduardo Franco-Chalco, Luz Nateros-Porras, Sonia Tejada-Muñoz, Denices Abarca-Fernandez, Iris Jara-Huayta, Roberto Zegarra-Chapoñan

Subject: Public Health And Healthcare, Other Keywords: depression; mental health; COVID-19; alcohol drinking; health occupations students

Online: 16 July 2024 (13:01:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1055.v2

Theory of Change for Building Stronger Wildlife Health Surveillance Systems Globally

Liz P. Noguera Z., Carrie Kappel, Marcela M. Uhart, François Diaz, Claire Cayol, Keren Cox-Witton, Clare Death, Damien O. Joly, Kevin Brown, Emma G. Gardner, Sarin Suwanpakdee, Bernard Bett, Kim M. Pepin, Kacey Yellowbird, Dina Saulo, Oliver Morgan, Sarah H. Olson, Mathieu Pruvot

Subject: Public Health And Healthcare, Other Keywords: one Health; wildlife health surveillance; WHIN

Online: 16 July 2024 (10:34:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.1249.v1

The Personalized Inherited Signature Predisposing to Non-small Cell Lung Cancer in Non-smokers

Viola Bianca Serio, Diletta Rosati, Debora Maffeo, Angela Rina, Marco Ghisalberti, Cristiana Bellan, Ottavia Spiga, Francesca Mari, Maria Palmieri, Elisa Frullanti

Subject: Public Health And Healthcare, Other Keywords: whole-exome sequencing; lung cancer susceptibility; germline variants; next-generation sequencing; oligogenic model

Online: 16 July 2024 (10:08:28 CEST)

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Lung cancer (LC) continues to be an important public health problem being the most common form of cancer and a major cause of cancer deaths worldwide. Despite the great bulk of research to identify genetic susceptibility genes by genome-wide association studies, only few loci associated to nicotine dependence have been consistently replicated. Our previously published study in few phenotypically discordant sib-pairs identified a combination of germline truncating mutations in known cancer susceptibility genes in never smoker early-onset LC patient does not present in their healthy sib. These results firstly demonstrated the presence of an oligogenic combination of disrupted cancer predisposing genes in non-smokers patients, giving experimental support to a model of a “private genetic epidemiology”. Here, we used a combination of whole-exome and RNA sequencing coupled with a discordant sib’s model in a novel cohort of pairs of never-smokers early-onset LC patients and in their healthy sibs used as controls. We selected rare germline variants predicted as deleterious by CADD and SVM bio-informatics tools and absent in the healthy sib. Overall, we identified an average of 200 variants per patient, about 10 of which in cancer predisposing genes. In most of them, RNA sequencing data reinforced the pathogenic role of the identified variants showing: i) downregulation in LC tissue (indicating “second hit” in tumor suppressor genes); ii) upregulation in cancer tissue (likely oncogene); iii) downregulation in both normal and cancer tissue (indicating transcript instability). The combination of the two techniques demonstrates that each patient has an average of six (with a range from four to eight) private mutations with functional effect in tumor predisposing genes. The presence of a unique combination of disrupting events in the affected subjects may explain the absence of familial clustering of non-small cell lung cancer. In conclusion, these findings indicate that each patient has his/her own “predisposing signature” to cancer development and suggest the use of personalized therapeutic strategies in lung cancer.

Preprint ARTICLE | doi:10.20944/preprints202407.1055.v1

Theory of Change for Building Stronger Wildlife Health Surveillance Systems Globally

Liz P. Noguera Z., Carrie Kappel, Jonathan M. Sleeman, Marcela M. Uhart, François Diaz, Claire Cayol, Keren Cox-Witton, Clare Death, Damien O. Joly, Kevin Brown, Emma G. Gardner, Sarin Suwanpakdee, Bernard Bett, Kim M. Pepin, Kacey Yellowbird, Dina Saulo, Oliver Morgan, Sarah H. Olson, Mathieu Pruvot

Subject: Public Health And Healthcare, Other Keywords: One Health; wildlife health surveillance; WHIN

Online: 15 July 2024 (19:36:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0912.v1

The Demand of Forest Bathing in the Northern Italy’s Regions

Francesca Visintin, Ivana Bassi, Vanessa Deotto, Luca Iseppi

Subject: Public Health And Healthcare, Other Keywords: Forest bathing demand; Forest Ecosystem Services; Tourists’ attitude; Willingness To Pay

Online: 11 July 2024 (04:52:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0642.v1

Cardiomyocyte Regeneration in Human Myocarditis

Andrea Frustaci, Eleonora Foglio, Federica Limana, Michele Magnocavallo, Emanuela Frustaci, Leonardo Lupacchini, Romina Verardo

Subject: Public Health And Healthcare, Other Keywords: myocarditis; newly generated cardiomyocytes; STAT3.

Online: 9 July 2024 (14:04:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0709.v1

Marine Peloids for Skin Care and Thalasso-Wellness

MARIA LOURDES MOURELLE, Carmen Paula Gómez, Ankurita Kashyap, José Luis Legido

Subject: Public Health And Healthcare, Other Keywords: marine peloids; skin care; thalassotherapy; wellness; dermo-cosmetics.

Online: 9 July 2024 (08:35:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0649.v1

Design a Digital Tool Using Design Thinking to Monitor Patients with Atopic Dermatitis

Laura Visiers-Jiménez, Marta González-Ramos, Marta Benito-Miguel, Lourdes Navalpotro-Fuster, Nuria María De Castro-De Frutos, Elena García-García

Subject: Public Health And Healthcare, Other Keywords: Dermatology; Atopic dermatitis; E-health; Self-management; Life Change Events; M-health; Patients

Online: 8 July 2024 (13:53:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0419.v1

Objective Refraction Status Before and After Cycloplegia: From Childhood to Young Adulthood

Karola Panke

Subject: Public Health And Healthcare, Other Keywords: cycloplegia, cyclopentolate, refractive error, autorefractometer, prevalence

Online: 4 July 2024 (13:33:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202407.0229.v1

Enhancing Mental Health in Stressed College Students during COVID-19: The Impact of Positive Psychology-Based Virtual Music Therapy

Jinwoo Han, Hyejin Lee, Teri Kim, Sangyeol Lee

Subject: Public Health And Healthcare, Other Keywords: virtual music therapy; positive psychotherapy; mental health; stress reduction; anxiety; depression; self-efficacy; resilience; COVID-19

Online: 3 July 2024 (04:24:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints202407.0047.v1

Multifactorial Contributors to the Longevity of Dental Restorations: An Integrated Review of Related Factors

Maria Jacinta Moraes Coelho Santos, Elham Zare, Peter McDermott, Gildo Coelho Santos Jr.

Subject: Public Health And Healthcare, Other Keywords: dental restorations; longevity; tooth-related factors; patient-related factors,; dentist-related factors; restoration failure; direct restorations; amalgam; composite resin; glass ionomer cement

Online: 1 July 2024 (08:32:55 CEST)

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Purpose: This integrated review aims to identify and analyze the multifactorial contributors to the longevity of direct restorations, focusing on tooth-, patient-, and dentist-related factors. Materials and Methods: A literature search was performed using an electronic database, PubMed/Medline, Web of Science, and Scopus, between 1980 and 2024. Titles and abstracts of papers that evaluated aspects categorized into tooth-related, patient-related, and dentist-related factors influencing restoration failure were selected and screened. Full-text assessments were conducted, and the extracted data were compiled, summarized, and synthesized. The reference lists of the collected papers were also screened, and relevant citations were included in this review. Data were gathered from clinical and laboratorial studies, systematic reviews, and meta-analyses to provide a comprehensive understanding of restoration longevity. Results: Among the tooth-related factors, multiple-surface restorations, deep margins, tooth location, and tooth vitality significantly impact restoration survival. Patient-related factors such as medical conditions, risk predictors of caries, age, sex, parafunctional habits, smoking, periodontal health, number of restorations, and socioeconomic status all play crucial roles. Regarding dentist-related factors, the decision-making process, age, experience, and dentist manual dexterity are vital aspects. Furthermore, the technique used, including isolation methods for moisture control, as well as the type of dental practice (large group vs. small practice), notably influenced the restoration survival. Conclusions: The longevity of dental restorations is influenced by a complex interplay of tooth-related, patient-related, and dentist-related factors. Strategies to improve restoration outcomes should consider all these multifactorial contributors. Continuing professional education, diligent patient guidance on the factors that influence restoration survival, careful material selection and restorative technique, and tailored individual treatment are crucial factors to reduce failure rates and improve the lifespan of restorations.

Preprint CASE REPORT | doi:10.20944/preprints202406.2028.v1

Successful Intraosseous (IO) Adenosine Administration for the Termination of SVT in 3,5 Years Old Child – Case Report and Literature Review

Jakub Zachaj, Łukasz Kręglicki, Tomasz Sikora, Katarzyna Oksana Moorthi, Filip Jaskiewicz, Klaudiusz Nadolny, Robert Gałązkowski

Subject: Public Health And Healthcare, Other Keywords: supraventricular tachycardia; intraosseous; adenosine; emergency; paediatrics

Online: 28 June 2024 (10:36:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1937.v1

Emergence of recombinant SARS-CoV-2 variants in California, 2020-2022

Rahil Ryder, Emily Smith, Deva Borthwick, Jesse Elder, Mayuri Panditrao, Christina Morales, Debra A. Wadford

Subject: Public Health And Healthcare, Other Keywords: SARS-CoV-2; genomic epidemiology; genomic surveillance; recombination; whole-genome sequencing; California COVIDNet

Online: 27 June 2024 (11:03:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1899.v1

Leveraging Data Warehousing for Healthcare Delivery – A case of Outpatient Department

Aggrey Obbo, William Wasswa, Annabella Basaza-Ejiri

Subject: Public Health And Healthcare, Other Keywords: Data Warehousing; Healthcare; Electronic health records; Outpatients

Online: 27 June 2024 (00:01:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1711.v1

Advancing Sustainable Healthcare Technology Management: Developing a Comprehensive Risk Assessment Framework with Fuzzy AHP, Integrating External and Internal Factors in the Gulf Region

Tasneem Mahmoud, Wamadeva Balachandran, Saleh Altayyar

Subject: Public Health And Healthcare, Other Keywords: healthcare technology management (HTM); healthcare risk management (HRM); healthcare technology risk management (HTRM); fuzzy analytic hierarchy process (AHP); endogenous risk factor; exogenous risk factors; facility management; regulatory compliance; blue print; enterprise risk management; PESTLE; comparison matrix; sustainability; healthcare system

Online: 25 June 2024 (16:32:50 CEST)

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In the context of healthcare technology management (HTM) in Saudi Arabia and the Gulf region, this study addresses a significant gap by exploring both external and internal risk factors affecting HTM performance. Previous research has primarily focused on modeling or predicting failures in medical devices, mostly examining internal (endogenous) factors that impact device performance and the development of optimal service strategies. However, a comprehensive investigation of external (exogenous) factors has been notably absent. This research introduces a novel hierarchical risk management framework, designed to accommodate the broad array of healthcare technologies, not limited to medical devices. It significantly advances the field by thoroughly investigating and validating a comprehensive set of 53 risk factors and assessing their influence on HTM. Additionally, this study embraces the perspective of enterprise risk management (ERM) and expands it to identify and incorporate a wider range of risk factors, offering a more holistic and strategic approach to risk assessment in healthcare technology management. The findings reveal that several external and internal factors previously underexplored significantly impact HTM performance. Notably, the Fuzzy AHP survey identified “design risk” under facility and environmental risks as the highest risk for HTM in the region. Furthermore, the study reveals that three out of the top ten risks are related to “facility and internal environmental” factors, six are related to technological endogenous factors, and only one is related to managerial factors. This distribution underscores the critical areas for intervention and the need for robust facility and technology management strategies. In conclusion, this research not only fills a critical void by providing a robust framework for healthcare technology risk assessment but also broadens the scope of risk analysis to include a wider array of technologies, thereby enhancing the efficacy and safety of healthcare interventions in the region. Additionally, the proposed hierarchy provides insights into the underlying risk factors for healthcare technology management, with potential applications extending beyond the regional context to a global scale. Moreover, the equation we propose offers a novel perspective on the key risk factors involved in healthcare technology management, presenting insights with far-reaching implications applicable not only regionally but also on a global level. This framework also supports sustainability goals by encouraging the efficient and responsible utilization and management of healthcare technologies, essential for ensuring the long-term economic and environmental sustainability of medical technology use.

Preprint ARTICLE | doi:10.20944/preprints202406.1782.v1

Longitudinal Associations between Emotional Resilience and Mental Health among Chinese Adolescents in the School Context: The Mediating Role of Positive Emotions

Zhongmin Zhu, Biao Sang, Junsheng Liu, Yuyang Zhao, Ying Liu, Ning Liu

Subject: Public Health And Healthcare, Other Keywords: adolescents; emotional resilience; positive emotions; mental health

Online: 25 June 2024 (16:25:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1690.v1

Comprehensive Criteria for Reporting Qualitative Research–(CCQR): Reporting Guideline for Global Health Qualitative Research Methods

Priyanka Sinha, Binita Paudel, Hanan Ahmed, Tamara Mosimann, Angel Phuti, Gaotswake Patience Kovane, Mirian Moagi

Subject: Public Health And Healthcare, Other Keywords: Qualitative Reporting Guidelines; Qualitative Research Reporting; Qualitative Research Standards; Qualitative Research Outcome; Reporting Guidelines in Qualitative Research; Qualitative Research Checklist

Online: 24 June 2024 (13:53:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1479.v1

Physiological Impacts of Energy Drink Consumption: A Clinical Analysis in Adolescents

Gilad Naveh, Bshara Mansour, Mahmoud Bader, Rafi Steckler, Elias Nasrallah, Hamed Hujeyrat, Faiga Magzal, Nael Elias, Omer Horovitz, Lili Nimri

Subject: Public Health And Healthcare, Other Keywords: adolescents; energy drinks; caffeine; glycemic control; insulin; glucose

Online: 21 June 2024 (07:26:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.1348.v1

Quality of Life of the Primary Caregiver of Cleft Lip and Palate Patients

María del Carmen Villanueva-Vilchis, Karen Esperanza Almanza-Aranda, Luis Alberto Gaitán-Cepeda, Rubén Rangel-Salazar, María de los Ángeles Ramírez-Trujillo, Fátima del Carmen Aguilar-Díaz, Javier de la Fuente Hernández

Subject: Public Health And Healthcare, Other Keywords: Cleft Lip; Cleft Palate; Caregivers; Quality of Life

Online: 19 June 2024 (11:49:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.1189.v1

Understanding the Transmission Dynamics of the Chikungunya Virus in Africa

Yajna Ramphal, Houriiyah Tegally, James Emmanuel San, Martina Reichmuth, Marije Hofstra, Eduan Wilkinson, Cheryl Baxter, CLIMADE Consortium, Tulio de Oliveira, Monika Moir

Subject: Public Health And Healthcare, Other Keywords: Chikungunya virus; Africa; transmission dynamics; epidemiology; genomic distribution; genomic surveillance

Online: 18 June 2024 (08:09:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0900.v1

Does tDCS Selectively Modulate the Pre-frontal Cortex Hemodynamics? An Immediate Effect-Controlled Trial on Depressed and Healthy People

Laura Oliveria Campos, Maria de Cássia Gomes Souza Macedo, Vheyda Katheleen Vespasiano Monerat, Kariny Realino do Rosário Ferreira, Mayra Evelise Cunha dos Santos, Arthur Ferreira Esquirio, Ana Luiza Guimarães Alves, Gabriela Lopes Gama, Alexandre Carvalho Barbosa

Subject: Public Health And Healthcare, Other Keywords: Near-infrared spectroscopy; oxyhemoglobin; oxygen saturation

Online: 13 June 2024 (08:03:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0869.v1

Noninvasive Estimation of Intracavitary Cardiac Pressures Using Speckle Tracking Echocardiography in Advanced Heart Failure

Luca Martini, Matteo Lisi, Maria Concetta Pastore, Francesca Maria Righini, Andrea Rubboli, Michael Y. Henein, Matteo Cameli

Subject: Public Health And Healthcare, Other Keywords: heart failure; speckle tracking echocardiography; heart cathetherization; myocardial oxygen consumption; myocardial fibrosis

Online: 12 June 2024 (23:50:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0812.v1

Consumption of snack foods by children and adolescents and their parents' knowledge about substances added to food

Agnieszka Kolmaga, Anna Garus-Pakowska

Subject: Public Health And Healthcare, Other Keywords: knowledge of parents; snack food; consumption; children and adolescents; food additives.

Online: 12 June 2024 (11:13:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0357.v1

Digital Twins as Global Learning Health and Disease Models of Individuals

Xinxiu Li, Joseph Loscalzo, AKM Firoj Mahmud, Dina Mansour Aly Aly, Andrey Rzhetsky, Marinka Zitnik, Mikael Benson

Subject: Public Health And Healthcare, Other Keywords: Global equitable health; Digital twin; Personalized treatment

Online: 7 June 2024 (11:06:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0479.v1

Optimization of Magnetic Susceptibility Weighted Imaging for Female Pelvic Scans

Wenjie Liu, Bin Yu, Furong Lv, Kaiwen Liang, Zhibo Xiao

Subject: Public Health And Healthcare, Other Keywords: magnetic resonance imaging; magnetic susceptibility weighted imaging; flip angle; pelvic disease.

Online: 7 June 2024 (10:24:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202406.0384.v1

A Reanalysis of an Italian Study on the Effectiveness of COVID-19 Vaccination Suggests That It Might Have Unintended Effects on Total Mortality

Marco Alessandria, Giovanni Malatesta, Franco Berrino, Alberto Donzelli

Subject: Public Health And Healthcare, Other Keywords: COVID-19 vaccines; Immortal-time Bias; Healthy-vaccinee bias; all causes mortality

Online: 6 June 2024 (12:48:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202406.0092.v1

Using a Syndemics Perspective to (Re)conceptualize Vulnerability during the COVID-19 Pandemic: A Scoping Review

Yisel Hernandez Barrios, Dennis Perez Chacon, Yosiel Molina Gomez, Charlotte Gryseels, Kristien Verdonck, Koen Peeters Grietens, Claudia Nieto-Sanchez

Subject: Public Health And Healthcare, Other Keywords: syndemics; vulnerability; COVID-19; syndemic interactions; bio-social interface

Online: 4 June 2024 (04:17:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.2146.v1

Testing and Visualization of Associations in Three-Way Contingency Tables: A Study on Gender Gap in Patients with Type I Diabetes and Cardiovascular Complications

Rosaria Lombardo, Eric J. Beh, Francesco Prattichizzo, Giuseppe Lucisano, Antonio Nicolucci, Björn Eliasson, Hanne Krage Carlsen, Rosalba La Grotta, Valeria Pellegrini, Antonio Ceriello

Subject: Public Health And Healthcare, Other Keywords: cardiovascular complication; Pearson’s three-way chi-squared statistic; partitioning; three-way correspondence analysis

Online: 31 May 2024 (11:35:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0454.v2

Development of Biomedical Technology From the Perspective of Ethics and Law

Zhangsheng Sun, Kexin Zhang

Subject: Public Health And Healthcare, Other Keywords: ; Biomedical technology; Ethics principle; Law risk; Canonical protection

Online: 29 May 2024 (07:34:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1874.v1

Lycium Barbarum Glycopeptide Alleviates Retinal Inflammation by Suppressing Microglial M1 Polarization via NF-κB/MAPK Pathways

Yiwen Ou, Yinhua Huang, Xu Yang, Lian Li, Rangsheng Mei, Zhexiong Yu, Kwok-Fai So, Jiansu Chen, Shibo Tang, Hongjie Jacey Ma

Subject: Public Health And Healthcare, Other Keywords: Lycium barbarum glycopeptide; retinal diseases; microglia; polarization; NF-κ B; MAPK

Online: 29 May 2024 (06:54:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1791.v1

Suicide Epidemic in a Medium-Sized City in Brazil Reveals Itself as a Youth Problem: A Survey

JULIANO FLAVIO RUBATINO RODRIGUES, Lívia Rodrigues, Fernando Rubatino, Kelly Atalaia da Silva, Franciany Rodrigues, Pedro Marco Karan Barbosa, Marcelo Carbone Carneiro, Edward Goulart Junior, Moacir Godoy, Gerardo Araújo Filho, Hannes Fischer, Spencer Payão

Subject: Public Health And Healthcare, Other Keywords: Suicide; Survey; Prevalence; Epidemiology; Suicidal ideation

Online: 28 May 2024 (09:00:53 CEST)

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Contrary to what has been happening in most countries in the world, suicide mortality in Brazil has been increasing since 2016. To identify the epidemiological profile that may be associated with this increase in suicidal behavior in the population, we looked for a city with low rates of suicide mortality until 2016 and in which had a detectable growing epidemic wave in recent years to better elucidate the issue. This study aims to identify factors associated with suicidal ideation, suicidal planning, suicide attempts, and suicide.A validated questionnaire was used - Kaiser-Meyer-Olkin index (KMO) = .86 (acceptable greater than .7) and intraclass correlated coefficient (ICC) = .98 (acceptable greater than .9). Data collected was obtained by sampling for the convenience of the online questionnaire with a minimum sample of 400 respondents. The general population of Marília’s city, a medium-sized city in São Paulo state of Brazil, voluntarily responded to the questionnaire. Prevalence data was described in ratios and incidence was described in tables. The association was measured by factor analysis. The state government's data information platform (DataSUS) was consulted to verify the incidence of suicides from 2016 to 2023. The prevalence ratio of suicide attempts in people with mental disorders was 8.09%. There was a 600% increase in the incidence of suicide from 2016 to 2023 among young adults. Interpersonal problems were highly prevalent in people with suicidal ideation, suicidal planning, and suicide attempts. Heroism appears to be a suicidal equivalent and may be associated with most young deaths. Heroic behavior demonstrated a prevalence of 66.1% for committing tragic suicide. We get c² of 31.4 for 18 degrees of freedom (p=0.026) of 10 representative variables in factor analysis with eight of the 10 variables demonstrating an association for one component. The young population has demonstrated epidemically growing suicide rates. Social segregation can affect young people's social lives and increase suicidal behavior.

Preprint ARTICLE | doi:10.20944/preprints202405.1640.v1

Bonding Effectiveness of Zirconia to Veneering Ceramic after Different Sandblasting Treatments

Francesca Zicari, Carlo Monaco, Marcio Vivan Cordoso, Davide Silvestri, Bart Van Meerbeek

Subject: Public Health And Healthcare, Other Keywords: Zirconia, Veneering ceramic, Surface treatments, Sandblasting, Surface roughness, Microtensile bond-strength.

Online: 24 May 2024 (11:19:47 CEST)

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Objective: To determine the effect of sandblasting before and after sintering on the surface roughness of zirconia and the micro-tensile bond strength of a pressable veneering ceramic to zirconia. Methods: Pre-sintered zirconia blocks (IPS e.max ZirCAD, Ivoclar Vivadent) were divided into a control group (CTR, no surface treatment) and four test groups of three specimens each: Pre-S-30, Pre-S-50, Pre-S-110 were sandblasted with 30µm SiO2, 50µm Al2O3 and 110µm Al2O3 particles respectively, before sintering, Post-S-30 was sandblasted with 30µm SiO2 after sintering. For each treatment, the surface roughness was measured (Ra, Perthometer M4P, Mahr Perthen). After sintering the zirconia blocks, a liner and a pressable ceramic (IPS e.max ZirPress, Ivoclar Vivadent) were fired. Sixteen micro-bars were obtained from each block and submitted to the micro-tensile bond strength (µTBS) test. Data were analyzed with one-way ANOVA. Any correlation between Ra and µTBS was evaluated (Sperman test). Results: Sandblasting before sintering with 110µm Al2O3 (Ra=3.44±0.44µm), 50µm Al2O3 (Ra=2.32±0.46µm), and 30µm SiO2 (Ra=1.22±0.22µm) resulted in significantly higher roughness than sandblasting after sintering with 30µm SiO2 (Ra=0.46±0.11µm). The highest µTBS was measured when the sintered zirconia was sandblasted with 30μm SiO2 (26.79±14.80 MPa), which was significantly different from that of specimens that were sandblasted before sintering (Pre-S-30=20.90±11.70; Pre-S-50=21.27±15.19; Pre-S-110=23.99±16.83) or were not treated (CTR=17.44±14.03). Conclusions: Sandblasting zirconia before sintering enhances the surface roughness proportionally to the particle size of the sand used. Sandblasting with 30µm SiO2 after sintering appeared to improve bonding between the veneering ceramic and zirconia. Clinical Significance: Sandblasting with 30µm SiO2 after sintering may improve bonding between veneering ceramics and zirconia, thus reducing ceramic fractures/chippings.

Preprint ARTICLE | doi:10.20944/preprints202405.1577.v1

A Covid-19 Prediction Approach: Prediction of Infectious Disease Probability Using Machine Learning

Mohsen Asghari Ilani, Saba Moftakhar Tehran, Ashkan Kavei, Arian Radmehr

Subject: Public Health And Healthcare, Other Keywords: Machine Learning; Deep Learning; Random Forest; CatBoost; XGBoost; COVID-19

Online: 23 May 2024 (16:54:01 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202405.1571.v1

Development of Epidemiological Research Guidelines for Myalgic Encephalomyelitis / Chronic Fatigue Syndrome in Canada

Enkhzaya Chuluunbaatar-Lussier, Travis Boulter, Sunita Vohra, Rahul Shetty, Sharon Houle, Riina Bray, Kathleen Kerr, Luis Nacul

Subject: Public Health And Healthcare, Other Keywords: myalgic encephalomyelitis or chronic fatigue syndrome (ME/CFS), research guidelines, standardization of data collection, Canadian

Online: 23 May 2024 (14:17:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.1474.v1

Exploring the Stress and Resilience Levels of Dental and Nursing Students in Response to Academic Responsibilities

Polyxeni Mangoulia, Antonia Kanellopoulou, Georgia Manta, Georgios Chrysochoou, Evangelos Dimitriou, Theodora Kalogerakou, Μaria Antoniadou

Subject: Public Health And Healthcare, Other Keywords: anxiety; nursing students; dental students; hope; stress; resilience; well-being

Online: 23 May 2024 (08:14:27 CEST)

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Students studying dentistry and nursing experience anxiety daily, which affects both their general well-being and academic achievement. Anxiety is exacerbated by several circumstances, such as stressors in one's personal life, clinical environment exposure, and academic expectations. To effectively regulate anxiety and support students' achievement, treatments that take these elements into account must be designed. In this study, 271 students from the National and Kapodistrian University of Athens, Greece's departments of dentistry and nursing were polled. Being the following resources, participants filled out an electronic questionnaire that was uploaded to Google Forms and assessed their levels of stress, anxiety, depression, resilience, hope, and spiritual well-being: a) the Depression, Anxiety, Stress Scale (DASS-21), b) the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-12), c) the Adult Hope Scale (AHS), d) the Resilience Assessment Questionnaire (RAQ8), and e) the Brief Resilience Scale (BRS). Additionally, demographic data was gathered, such as gender, educational attainment, family income, and country of origin. Statistical analyses were performed to investigate the relationships between the variables, including hierarchical multiple linear regression and t-tests. The sample consisted of 271 students from the Department of Nursing (n=126, 46.5%) and Dentistry (n=145, 53.5%), with 68.60% of them being female, 80.10% being undergraduate students, and 48.30% being from Athens, the country's capital. Comparatively speaking, 74.50 percent of nursing students were female, while 62.80% of dental students were. Compared to dental students (2.10%), nurses (40.50%) participated in postgraduate studies at a higher rate. Compared to dental students (44.80%), nursing students reported a household income of just 13.90%, which is much less than €35,000. Anxiety was reported by 51.30% of participants overall, with dental students reporting higher anxiety than nursing students. Higher family wealth was associated with reduced stress levels, while female undergraduate students reported higher levels of anxiety than their male counterparts. Hope was a strong predictor of resilience, but stress and worry had a negative correlation. Promoting students' well-being and academic success requires effective stress-reduction and resilience-building techniques aimed to not only improve student performance but also support future healthcare professionals' personal sustainability and holistic growth.

Preprint ARTICLE | doi:10.20944/preprints202405.1083.v1

Perception of Virtual Learning among Dental Residents and Faculty during the COVID-19 Pandemic

Shasha Cui, Kumari Saswati Kar, Shruti Vasani, Nisreen Al Jallad, Mechelle R Sanders, Rita Cacciato, Tong Tong Wu, Jin Xiao, Hans Malmstrom

Subject: Public Health And Healthcare, Other Keywords: dental education; distance education; dental residents and faculty; regulatory focus theory; burnout; covid-19

Online: 16 May 2024 (10:51:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0975.v1

Machine Learning Approaches for Stroke Risk Prediction: Findings from the Suita Study

Thien Vu, Yoshihiro Kokubo, Mai Inoue, Masaki Yamamoto, Attayeb Mohsen, Agustin Martin-Morales, Takao Inoué, Research Dawadi, Michihiro Araki

Subject: Public Health And Healthcare, Other Keywords: Stroke; supervised machine learning; unsupervised machine learning; Logistic Regression; Random Forest; Support Vector Machine (SVM); eXtreme Gradient Boost (XGBoost); Light Gradient Boosted Machine (Light-GBM); K-prototype clustering; Shapley Addictive ExPlanations (SHAP)

Online: 14 May 2024 (13:25:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0599.v1

The Effectiveness and Cost Outcomes of Korean Medicine for Anxiety Disorders: A Retrospective Case Series Study

So-Young Lee, Jong-Ho Yoo, Sang-Il Seo, Ji-Eun Lee, Geun-Woo Kim, Eun Cho

Subject: Public Health And Healthcare, Other Keywords: anxiety disorder; cost analysis; Korean medicine; quality of life; retrospective study

Online: 9 May 2024 (13:44:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0584.v1

“Prevalence of Dental Caries and Dietary Determinants among 12–16 Years Old Students, a Cross-Sectional Study”

Suela Hoxha, Fatime Hoxha, Jaser Veseli, Xheneta Hoxha

Subject: Public Health And Healthcare, Other Keywords: DMFT; soft drinks; frequency; adolescents

Online: 9 May 2024 (10:34:04 CEST)

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Introduction: Caries is a public health problem in Kosovo among children, Caries is a multifactorial microbial disease and connection of this disease with soft drinks and food habits between children and their poor oral health is very strong. Aim: The aim of present study is to evaluate prevalence of caries among 12 to 16 years old students in municipality of Suhareka and to analyze related risk factors that contribute in occurrence of caries. Material and methods: To observe parameters of soft drink we used experimental method and a cross-sectional study was carried out among 120 adolescents in “Sadri Duhla” elementary school in Duhel and “7 Marsi” elementary school in city of Suhareka. Oral clinical examination and self administered questionnaire were used to collect information about dental caries and its correlation to soft drinks and food habits. Examination was done between May and October in the year 2023. Impact of soft drink in caries was assessed through DMFT index and frequency of consumption of soft drinks. The data were collected statistically using SPSS version 26 and presented in tables and graphs. Results: The highest result of DMFT (4.36) with standard deviation 1.23 was noted in the group consuming more than 16 cans per week also the highest score in adolescent compared to frequency of consumed cans per week. Soft drinks found in Kosovo’s mar-kets are acidic with low pH, 93.75% of them had a pH below 4 which are considered erosive and only 6.25% are minimally erosive with a pH > 4, in terms of buffer capacity soft drinks can be ordered like this energy drinks >soda >100% fruit juice > fruit drinks. Improper tooth-brushing, dental visits only in case of pain and not preventive visits were significantly related to dental caries. Conclusion: The results of the research awarned us for high frequency consumption of soft drinks related to dental caries. It is recommended to be aware of the use of soft drinks, regular visits to the doctor, higher maintenance of oral health by using paste with sufficient fluoride content also brushing teeth 1 hour after consuming acidic food.

Preprint ARTICLE | doi:10.20944/preprints202405.0572.v1

Evaluating Double-Duty Actions in Rwanda’s Secondary Cities

Sophia Demekas, Helen Prytherch, Francine Bayisenge, Straton Habumugisha, Klaus Kraemer, Jimena Monroy-Gomez, Immaculee Nabacu, Cornelia Speich, Innocente Turinimigisha, Dominique Barjolle

Subject: Public Health And Healthcare, Other Keywords: double burden of malnutrition; food system transition; nutrition policy; nutrition interventions

Online: 9 May 2024 (07:46:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1418.v2

Cancer Incidence Rates in the US in 2016–2020 with Respect to Solar UVB Doses, Diabetes and Obesity Prevalence, Lung Cancer Incidence Rates, and Alcohol Consumption: An Ecological Study

William B. Grant

Subject: Public Health And Healthcare, Other Keywords: alcohol consumption; cancer incidence; diabetes mellitus; diet; ecological study; lung cancer; obesity; solar UVB, USA; vitamin D

Online: 7 May 2024 (11:57:17 CEST)

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Abstract: This article reports the results of an ecological study of cancer incidence rates by state in the US for the period 2016-2020. The goals of this study were to determine the extent to which solar UVB doses still reduced cancer risk compared to findings reported in 2006 for cancer mortality rates for the periods 1950–1969 and 1970-1794 as well as cancer incidence rates for the period 1998–2002 and to determine which factors were recently associated with cancer risk. The cancer data for non-Hispanic white (European American) men and women were obtained from the Centers for Disease Control and Prevention. Indices were obtained for solar UVB at the surface for July 1992, and alcohol consumption, and diabetes and obesity prevalence near the 2016–2020 period. Lung cancer incidence rates were also used in the analyses as a surrogate for smoking, diet, and air pollution. The cancers for which solar UVB is significantly associated with reduced incidence are bladder, brain (males), breast, corpus uteri, esophageal, gastric, non-Hodgkin’s lymphoma, pancreatic, and renal cancer. Lung cancer was significantly associated with colorectal, laryngeal, and renal cancer. Diabetes was also significantly associated with breast, liver, and lung cancer. Obesity prevalence was significantly associated with breast, colorectal and renal cancer. Alcohol consumption was associated with bladder and esophageal cancer. Thus diet has become a very important driver of cancer incidence rates. The role of solar UVB in reducing risk of cancer has been reduced due to people spending less time outdoors, wearing sunscreen that blocks UVB but not UVA radiation, and population increases in overweight and obesity, which lowers 25-hydroxyvitamin D concentrations and generates systemic inflammation, a risk factor for cancer. The dietary approach that would reduce the risk of diabetes, obesity, lung cancer, and, therefore cancer, would be one based mostly on whole-plants and restrictions on red and processed meats and ultraprocessed foods. Solar UVB exposure for a few minutes before applying sunscreen and taking vitamin D supplements would also help reduce risk of cancer.Keywords: alcohol consumption; cancer incidence;

Preprint ARTICLE | doi:10.20944/preprints202405.0317.v1

Vaccine Refusal and Hesitancy in Spain: An Online Cross-Sectional Questionnaire

Agnes Huguet-Feixa, Eva Artigues-Barberà, Joaquim Sol, Xavier Gómez-Arbonés, Pere Godoy, Marta Ortega Bravo

Subject: Public Health And Healthcare, Other Keywords: anti-vaccination movement; anti-vaccine; vaccination refusal; vaccine hesitancy

Online: 7 May 2024 (03:24:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0275.v1

Shear-Wave Ultrasonographic Elastography in Pediatric Spleen and Its Role in Differential Diagnosis

Turkhun Cetin, Oguzhan Tokur, Hayrunnisa Bekis Bozkurt, Sonay Aydin, Kemal Bugra Memis, Mecit Kantarci

Subject: Public Health And Healthcare, Other Keywords: childhood; spleen; stiffness; ultrasound; Shear Wave Elastography (SWE)

Online: 6 May 2024 (09:31:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0264.v1

Understanding the Spectrum and Determinants of Child Abuse and Neglect in Nkpor-Uno, Anambra State, Nigeria

Nwankwo Nonyelum Stella

Subject: Public Health And Healthcare, Other Keywords: ; child abuse; child neglect; Nkpor-Uno; Nigeria; spectrum; determinants ;

Online: 6 May 2024 (09:26:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0171.v1

A Multichannel CT and Radiomics-Guided CNN-ViT (RadCT-CNNViT) Ensemble Network for Diagnosis of Pulmonary Sarcoidosis

Jianwei Qiu, Jhimli Mitra, Soumya Ghose, Camille Dumas, Jun Yang, Brion Sarachan, Marc A. Judson

Subject: Public Health And Healthcare, Other Keywords: pulmonary sarcoidosis; chest CT; radiomics; ensemble network; vision transformer; CNN

Online: 3 May 2024 (07:31:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0110.v1

Assessing the Suitability of CHA2DS2-VASc for Predicting Adverse Limb Events and Cardiovascular Outcomes in Peripheral Artery Disease Patients

Yu-Tsung Cheng, Fu-Lan Chang, Po-Hsien Li, Wen-Chien Lu, Chien-Shan Chiu

Subject: Public Health And Healthcare, Other Keywords: Peripheral artery disease (PAD); modified cumulative risk (MCR) score; CHA2DS2-VASc; Major adverse cardiovascular events (MACE); Major adverse limb events (MALE); percutaneous coronary intervention (PCI)

Online: 2 May 2024 (09:41:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0030.v1

Team Sports as Catalysts for Holistic Student Wellness: Insights from a General Review

Xiaolei Kang, Qing Meng, Chun-Hsien Su

Subject: Public Health And Healthcare, Other Keywords: holistic development; physical activity benefits; educational strategies; wellness frameworks; student engagement; inclusive sports programs

Online: 1 May 2024 (04:31:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1755.v1

A Comprehensive Global Review of Epidemiology, Clinical Management, Socio-Economic Impacts and National Responses of Long COVID with Future Research Directions

Xiufang Song, Weiwei Song, Lizhen Cui, Tim Q Duong, Rajiv Pandy, Hongdou Liu, Qun Zhou, Jiayao Sun, Yanli Liu, Tong Li

Subject: Public Health And Healthcare, Other Keywords: coronavirus risk factors; multisystem impact; public health response; counter measure

Online: 26 April 2024 (14:48:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.1585.v1

One Health Scoping Review of the Epidemiology of Human Fascioliasis across Africa for the Period 2000–2022

Moses Adriko, Edridah M. Tukahebwa, Miph B. Musoke, David Muwanguzi, Stellah Nambuya, Patrick Vudriko, Kalinda Chester, Samson Mukaratirwa, Moses J. Chimbari, Anna-Sofie Stensgaard, Birgitte Vennervald, Lawrence Mugisha

Subject: Public Health And Healthcare, Other Keywords: human-fascioliasis; prevalence; epidemiology; Africa; One-Health

Online: 25 April 2024 (15:07:38 CEST)

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(1)Background: Fascioliasis is considered a neglected tropical disease affecting an estimated 17 million people in more than 70 countries worldwide. The highest prevalence of human fascioliasis is found in regions where livestock farming and consumption of raw or undercooked freshwater plants are common, such as parts of Africa, Asia, Europe, and Latin America. It is responsible for over 90,000 disability-adjusted years of life due to associated abdominal complications. We conducted a study to investigate the prevalence of human fascioliasis through a systematic review and meta-analysis of all available literature in Sun-Saharan Africa.(2). Methods: We screened a total of 126 publications using pubmed online search engine databases; Web of Science and CAB for articles published within a 20-year period between 2000 and 2022. We used a comprehensive search method using a combination of terms, parasite and disease names. The initial search resulted in a screening of articles by title, abstracts and full texts. The relevant information on the prevalence of human fascioliasis in Africa was extracted. Of the 126 publications, 33 articles were selected for meta-analysis. The essential information required was extracted from these documents and determined through statistical analysis in Microsoft Excel for calculating the prevalence of human fascioliasis in sub-Saharan Africa. The variance of each study was assessed using a bimodal distribution and heterogeneity assessment using a I2 index. Analysis was performed using random effects models.(3)Results: A total of 271 articles were searched through the database search and 33 articles were eligible studies that provided qualitative information on the prevalence of human fascioliasis in Africa. These make up 12.17% (n=33). The pooled prevalence estimates for human fascioliasis are 0.032% (IVhet PPE: 0.032% (95%CI 1.4-6.53). The highest prevalence rate was observed in Egypt with a prevalence of 100%. The prevalence of human fascioliasis is very high in some sub-Saharan countries, partly due to neglect of diagnostics, demonstrating the bias of available information for decision-making in human fascioliasis across Africa, given the spatial presence, scarcity and incompleteness are region.(4)Conclusions: The prevalence of Human fascioliasis is very high in some Sub-Saharan Countries partly due to neglect in diagnostics. This presents how highly focal with spatial occurrences, scarcity and patchy the available information for decision making is on Human fascioliasis across the Sub-Saharan African region.

Preprint ARTICLE | doi:10.20944/preprints202404.1418.v1

Cancer Incidence Rates for non-Hispanic White Men and Women in the US in 2016–2020 with Respect to Solar UVB Doses, Diabetes and Obesity Prevalence, Lung Cancer Incidence Rates, and Alcohol Consumption: An Ecological Study

William B. Grant

Subject: Public Health And Healthcare, Other Keywords: alcohol consumption; cancer incidence; diabetes mellitus; diet; ecological study; lung cancer; obesity; solar UVB, USA; vitamin D

Online: 23 April 2024 (11:48:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1102.v1

Relationship Between Perception of Quality of Life and Nutri-tional Status of Mothers Caring For Childrew With Type 1 Diabetes Mellitus

Maria de Nazareth de Lima Carneiro, Arthur Andrade da Fonseca, Rachel Coelho Ripardo, Layla Sandia Cezário Alves, Manuela Maria de lima Carvalhal, Daniela Lopes Gomes

Subject: Public Health And Healthcare, Other Keywords: Quality of life; Health of caregivers; Nutritional status; type 1 diabetes

Online: 17 April 2024 (15:04:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1148.v1

Experimental Setup for Evaluating Depth Sensors in Augmented Reality Technologies Used in Medical Devices

Valentyn Stadnytskyi, Bahaa Ghammraoui

Subject: Public Health And Healthcare, Other Keywords: augmented reality; virtual reality; validation; evaluation; image registration

Online: 17 April 2024 (13:28:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1166.v1

Effects of Lipid Phase Content on the Technological and Sensory Properties of O/W Emulsions Containing Bemotrizinol Loaded Nanostructured Lipid Carriers

Debora Santonocito, Carmelo Puglia, Lucia Montenegro

Subject: Public Health And Healthcare, Other Keywords: bemotrizinol; emulsions; sensory evaluation; UV-filters; lipid nanoparticles; in vitro SPF

Online: 17 April 2024 (13:05:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.1127.v1

Quality of Life after Mastectomy with or without Breast Reconstruction and Breast Conserving Surgery in Breast Cancer Survivors; A Cross-Sectional Study at a Tertiary Hospital in GHANA

Josephine Nsaful, Edmund T. Nartey, Florence Dedey, Antoinette Bediako-Bowan, Rita Appiah-Danquah, Kwame Darko, Levi Nii Ayi Ankrah, Cynthia Akli-Nartey, Jessie Yaoteokor Annan, Jessica Dei-Asamoa, George Amanquanor Ahene-Amanquanor, Joe-Nat Clegg-Lamptey

Subject: Public Health And Healthcare, Other Keywords: Breast cancer; EORTC QLQ; mastectomy; breast reconstruction; breast conservation; Quality of life

Online: 17 April 2024 (08:45:41 CEST)

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Preprint ESSAY | doi:10.20944/preprints202404.1063.v1

Post-COVID-19: Time to Change Our Way of Life for a Better Future

Roch Listz Maurice

Subject: Public Health And Healthcare, Other Keywords: COVID-19; pandemics; population density; prevention; public health

Online: 16 April 2024 (15:55:14 CEST)

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Rationale - From the year 1 anno Domini until 1855 with the third Plague, major pandemics occurred on average every 348 years. Since then, they have occurred on average every 33 years, with Coronavirus disease 2019 (COVID-19) now underway.Even though current technologies have greatly improved the way of life of human beings, COVID-19, with more than 700 000 000 cases and 6 950 000 deaths worldwide by the end of 2023, reminds us that much remains to be done. Objective - Given the frequency and duration of recent pandemics, it might be wise to start thinking about preventative methods to minimize the impact of future pandemics. This report looks back at 18 months of COVID-19, from March 2020 to August 2021, with the aim of highlighting potential solutions that could prove practical, or even essential, for the future. Material - COVID-19 data, including case and death reports, were extracted daily from the Worldometer platform to build a database for macroscopic analysis of the spread of the virus around the world. Demographic data were integrated into the COVID-19 database for a better understanding of the spatial spread of the SARS-CoV-2 virus in cities/municipalities. Method - Without loss of generality, we only analyzed data from the top 30 (out of 200 and above) countries ranked by total number of COVID-19 cases. Statistics (regression, t-test (p < 0.05), correlation, mean ± std, etc.) were carried out with Excel software. Spectral analysis, using Matlab software, was also used to try to better understand the temporal spread of COVID-19. Results - A good linear correlation was observed between the number of cases and the respective number of deaths depending on the country, i.e. y = 0.0121x + 19559 with R² = 0.8042. The analysis then focused mainly on the number of cases.This study showed that COVID-19 mainly affects G20 countries. The most interesting result is that cities/municipalities with high population density are a powerful activator of the spread of the virus. The current demographic context seems to be becoming a societal problem that must be addressed adequately.Spectral analysis highlighted that the very first months of spread of COVID-19 were the most notable with a strong expansion of the SARS-CoV-2 virus. On the other hand, the following six months showed a certain stability due mainly to multiple preventive measures such as confinement, closure of non-essential services, wearing of masks, distancing of 2 meters, etc. Discussion - Analysis of case and death data showed that COVID-19 mainly affects G20 countries. Nevertheless, the most interesting result of this study is that cities and municipal areas with population densities of several thousand inhabitants per square kilometer largely favored the spread of the SARS-CoV-2 virus. It is believed that such a demographic context is becoming a societal problem that developed countries around the world will sooner or later face and therefore needs to be adequately addressed. Conclusion - COVID-19 has made us understand that it is time to act both preventatively and curatively. Phenomenological insights suggest that the next pandemic could occur in less than 50 years. It may be time to launch new societal projects aimed at relieving congestion in densely populated regions.

Preprint ARTICLE | doi:10.20944/preprints202404.0963.v1

Retrospective Study on the Risk Factors for Resuscitation at Birth and Admission to the NICU in a Third Level Maternity

Florica Ramona Dorobanțu, Nicolae Ovidiu Pop, Dana Carmen Zaha, Dorina Gabriela Dascal, Ioana Coralia Codreanu, Carmen Pantiș, Parascovia Pop, Cătălin Dorin Dorobanțu

Subject: Public Health And Healthcare, Other Keywords: newborn; risk factors; resuscitation; emergency.

Online: 15 April 2024 (11:32:28 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0917.v1

Investigating the Interplay: Periodontal Disease and Type 1 Diabetes Mellitus - A Comprehensive Review of Clinical Studies

Stefania Vlachou, Alexandre Loume, Catherine Giannopoulou, Evangelos Papathanasiou, Alkisti Zekeridou

Subject: Public Health And Healthcare, Other Keywords: Diabetes mellitus; periodontitis; type 1 diabetes mellitus; molecular mechanisms; cellular mechanisms; oral microbiota; host immune response; oxidative stress; periodontal disease

Online: 15 April 2024 (07:26:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0601.v1

The number of health-promoting substances that all edible vascular plantscontain compared to the species-specific number of health-promoting substances of five Wild Edible Plants (WEPs)

Mauri Kalervo Åhlberg

Subject: Public Health And Healthcare, Other Keywords: wild edible plants (WEPs); wild food plants; Mediterranean diet; functional foods; good health, lon-gevity; Alzheimer’s disease; alimurgic plants; invasive species; sustainability

Online: 9 April 2024 (09:29:24 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202404.0572.v1

The Vulnerability of Children and Adolescents in Severe Diseases: Some Reflections

Giovanni (Gianni) Biondi

Subject: Public Health And Healthcare, Other Keywords: Pediatric psychology; the vulnerability of ill children and adolescents; communication (diagnosis, ill child/adolescent, parents, healthcare personnel); stress.

Online: 8 April 2024 (15:11:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0511.v1

Sarc-Global: A New Sarcopenia Screening Tool in Older Adults

Natalia Correia Lopes, Ana Carolina Costa Vicedomini, Natalia Vieira Magalhães, Dan L. Waitzberg, Wilson Jacob-Filho, Alexandre Leopold Busse, Douglas Ferdinando, Rosa Maria Rodrigues Pereira, Raquel S. M. M. Torrinhas, Giliane Belarmino

Subject: Public Health And Healthcare, Other Keywords: sarcopenia; older adults; sarcopenia screening; Sarc-F; Sarc-CalF; Sarc-Global

Online: 8 April 2024 (08:27:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0454.v1

Development of Biomedical Technology From the Perspective of Ethics and Law

Zhangsheng Sun, Kexin Zhang

Subject: Public Health And Healthcare, Other Keywords: ; Biomedical technology; Ethics principle; Law risk; Canonical protection

Online: 8 April 2024 (05:30:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202404.0175.v1

Domains and Categories of Needs in Long-term Follow-up of Adult Cancer Survivors: A Scoping Review of Systematic Reviews

Nicolas Sperisen, Dimitri Kohler, Nicole Steck, Pierre-Yves Dietrich, Elisabetta Rapiti

Subject: Public Health And Healthcare, Other Keywords: cancer survivors; needs; follow-up; supportive care; information; health system; assessment

Online: 2 April 2024 (09:41:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0070.v1

A Deep-Learning Approach to Automatic Tooth Caries Segmentation on Panoramic Radiographs of Children in Primary Dentition, Mixed Dentition, and Permanent Dentition

Esra Asci, Munevver Kilic, İbrahim Sevki Bayrakdar, Ozer Celik, Kaan Orhan, Kenan Cantekin, Hasan Basri Bircan

Subject: Public Health And Healthcare, Other Keywords: Caries, Artificial Intelligence, Panoramic Radiography, Deep Learning

Online: 1 April 2024 (12:26:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202403.1880.v1

Association of anti-interferon-γ autoantibodies with severe herpes zoster in rheumatoid arthritis patients treated with Janus kinase inhibitors

Po-Ku Chen, Yi-Ming Chen, Hsin-Hua Chen, Tsai-Ling Liao, Shih-Hsin Chang, Kai-Jieh Yeo, Po-Hao Huang, Der-Yuan Chen

Subject: Public Health And Healthcare, Other Keywords: Anti-interferon-γ autoantibodies; herpes zoster; monocyte chemoattractant protein-1; IFN-γ inducible protein-10; Janus kinas inhibitors; rheumatoid arthritis.

Online: 1 April 2024 (10:20:44 CEST)

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Public Health and Healthcare