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Preprint ARTICLE | doi:10.20944/preprints202007.0025.v1

COVID-19 Outpatients – Early Risk-Stratified Treatment with Zinc Plus Low Dose Hydroxychloroquine and Azithromycin: A Retrospective Case Series Study

Martin Scholz, Roland Derwand, Vladimir Zelenko

Subject: Medicine And Pharmacology, Pharmacy Keywords: SARS-CoV-2; COVID-19; outpatients; treatment; zinc; hydroxychloroquine; azithromycin

Online: 3 July 2020 (08:52:22 CEST)

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Objective: To describe outcomes of patients with coronavirus disease 2019 (COVID-19) in the outpatient setting after early treatment with zinc, low dose hydroxychloroquine, and azithromycin (the triple therapy) dependent on risk stratification. Design: Retrospective case series study. Setting: General practice. Participants: 141 COVID-19 patients with laboratory confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in the year 2020. Main Outcome Measures: Risk-stratified treatment decision, rate of hospitalization and all-cause death. Results: Of 335 positively PCR-tested COVID-19 patients, 127 were treated with the triple therapy. 104 of 127 met the defined risk stratification criteria and were included in the analysis. In addition, 37 treated and eligible patients who were confirmed by IgG tests were included in the treatment group (total N=141). 208 of the 335 patients did not meet the risk stratification criteria and were not treated. After 4 days (median, IQR 3-6, available for N=66/141) of onset of symptoms, 141 patients (median age 58 years, IQR 40-67; 73% male) got a prescription for the triple therapy for 5 days. Independent public reference data from 377 confirmed COVID-19 patients of the same community were used as untreated control. 4 of 141 treated patients (2.8%) were hospitalized, which was significantly less (p<0.001) compared with 58 of 377 untreated patients (15.4%) (odds ratio 0.16, 95% CI 0.06-0.5). Therefore, the odds of hospitalization of treated patients were 84% less than in the untreated group. One patient (0.7%) died in the treatment group versus 13 patients (3.5%) in the untreated group (odds ratio 0.2, 95% CI 0.03-1.5; p=0.16). There were no cardiac side effects. Conclusions: Risk stratification-based treatment of COVID-19 outpatients as early as possible after symptom onset with the used triple therapy, including the combination of zinc with low dose hydroxychloroquine, was associated with significantly less hospitalizations and 5 times less all-cause deaths.

Working Paper HYPOTHESIS

Potential Natural Compounds for Preventing 2019-nCoV Infection

Hansen Chen, Qiaohui Du

Subject: Medicine And Pharmacology, Pharmacy Keywords: 2019-nCov; Baicalin; Scutellarin; Hesperetin; Nicotianamine; Glycyrrhizin

Online: 30 January 2020 (03:06:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0486.v1

Azithromycin and Hydroxychloroquine Accelerate Recovery of Outpatients with Mild/Moderate COVID-19

Violaine Guérin, Pierre Lévy, Jean-Louis Thomas, Thierry Lardenois, Philippe Lacrosse, Emmanuel Sarrazin, Natacha Regensberg de Andreis, Martine Wonner

Subject: Medicine And Pharmacology, Pharmacy Keywords: COVID-19; SARS-CoV-2; azithromycin; hydroxychloroquine; primary care

Online: 31 May 2020 (17:51:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0286.v1

Network Bioinformatics Analysis Provides Insight into Drug Repurposing for COVID-2019

Xu Li, Jinchao Yu, Zhiming Zhang, Jing Ren, Alex E. Peluffo, Wen Zhang, Yujie Zhao, Kaijing Yan, Daniel Cohen, Wenjia Wang

Subject: Medicine And Pharmacology, Pharmacy Keywords: COVID-2019; SARS-CoV-2; repurposing; network bioinformatics

Online: 18 March 2020 (08:50:10 CET)

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Working Paper REVIEW

Pharmacy and Society: How Effective Communication Can Strengthen the Role of Community Pharmacist

Maria Laura Ilardo, Antonio Speciale

Subject: Medicine And Pharmacology, Pharmacy Keywords: effective communication; community pharmacy; pharmacist’s role; modern society; modern services; on-line pharmacy; pharmacy educational methodologies; communication skills improvement; pharmacist’s professionalism; efficient consultancy service

Online: 15 November 2019 (03:33:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0008.v1

Raman and Terahertz Spectroscopic Investigation of Cocrystal Formation Involving Antibiotic Nitrofurantoin Drug and Coformer 4-aminobenzoic Acid

Yong Du, Qiang Cai, Jiadan Xue, Qi Zhang

Subject: Medicine And Pharmacology, Pharmacy Keywords: nitrofurantoin; active pharmaceutical ingredient; 4-aminobenzoic acid; cocrystallization; intermolecular interaction; Raman spectroscopy; terahertz spectroscopy

Online: 1 November 2016 (09:54:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0108.v1

COVID-19: Comprehensive Synopsis of Suggested Pathophysiological Mechanisms and Repurposed Drugs

Mathijs Binkhorst, Annette K. Offringa, Johannes G. van der Hoeven

Subject: Medicine And Pharmacology, Pharmacy Keywords: COVID-19; SARS-CoV-2; coronavirus; hypothesis; pathophysiology; drug repurposing

Online: 7 July 2020 (02:50:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0324.v1

How Can ChatGPT Benefit Pharmacy: A Case Report on Review Writing

Yun Zhu, Dan Han, Shaoqing Chen, Feng Zeng, Cheng Wang

Subject: Medicine And Pharmacology, Pharmacy Keywords: ChatGPT; pharmacy; review; artificial intelligence

Online: 20 February 2023 (07:23:16 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202003.0247.v1

Prediction of Potential 3CLpro-Targeting Anti-SARS-CoV-2 Compounds from Chinese Medicine

Ning Sun, Wing-Leung Wong, Jiao Guo

Subject: Medicine And Pharmacology, Pharmacy Keywords: SARS-CoV-2; COVID-19; molecular docking; Chinese medicine; lithospermic acid B; specnuezhenide; neonuezhenide; rutin; neodiosmin

Online: 15 March 2020 (15:11:22 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0108.v1

Systematic Review on the Relevancy of Paracetamol and Breastfeeding Post Infants Vaccination

Nurain Suleiman, Siti Hadijah Shamsuddin, Razman Mohd Rus, Shamsul Drahman

Subject: Medicine And Pharmacology, Pharmacy Keywords: paracetamol; breastfeeding; post; childhood; prophylactic; immunization; vaccination

Online: 12 January 2018 (07:09:16 CET)

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Background: Paracetamol may be use as antipyretic agent for the treatment of fever, as well as an analgesic in the treatment of mild to moderate pain on post vaccination in infants. The use of Paracetamol during fever may be or may not be recommended since it may alter natural human body immune response although it may reduce pain. Objectives: This study described the relevancy of Paracetamol use post infants vaccination based on data collection systematic review analyses. This study aims to describe the effectiveness of breastfeeding in reducing pain and Paracetamol in reducing fever and pain post infants vaccination. Data Sources and Study Selection: Electronic literature search by hand searching six (6) databases which include Ovid LWW Total Access Collection and Medline, CINAHL (Cumulative Index to Nursing and Alled Health Literature) Plus with Fulltext, Science Direct, Proquest Dissertations and Theses, Proquest Education Journal and Proquest Health and Medical Complete. Additionally, manual reference checks of all articles on Paracetamol and breastfeeding post infants vaccination published in English Language between 1978 and 2017. Two level of screening were used on 9614 citations which include screening of abstracts and titles followed by full text screening. Data Synthesis: Data synthesis were tabulated into study characteristics, quality and effects. Authors of trials were not contacted for further details or provision of original data if the published report contained insufficient information. The study findings, as reported by the authors, were included in this review. The data in this research cannot be pool due to not enough data regarding odd ratio or relative risk as well as confidence interval in each study. Results: Systematic review of breastfeeding included three (3) studies from 9614 of database searching. The reviews of all these three (3) studies found significant benefit from breastfed in pain score and duration of crying as well as behavioral changes. None study stated the unbeneficial of breastfeeding before, during and after immunization. Meanwhile, systematic review of Paracetamol effectiveness included four (4) studies from 1177 of database searching. The reviews of two (2) studies found significant benefit from prophylaxis Paracetamol in fever and only one (1) study found significant benefit from prophylaxis Paracetamol in fussiness. On the other hand, there was one (1) study found not signifiant benefit from prophylaxis Paracetamol in fever. Other than that, there were two (2) studies evaluate the safety of prophylactic Paracetamol which revealed different outcomes, in which study by Prymula et. al. in 2009 found that antibody responses to several antigens were reduced significantly, and the other study by Uhari et. al. in 1988 found that antibody titres to DTP bacteria of placebo and PCM not differ significantly. Thus, Paracetamol seems to be not relevant post infants vaccination and breastfeeding was found to be beneficial post infants vaccination. Conclusions: The relevancy of giving Paracetamol post all types of vaccination may be questionable since the safety issue of this intervention may be arised. Breastfeeding before, during and after immunization are recommended for pain reduction as it was proved effectively. Finally, in deciding Paracetamol to be of rational use following infants immunization, it may need for further research which include in depth quantitative and qualitative studies to identify specific problem and causes regarding this issue.

Preprint ARTICLE | doi:10.20944/preprints202007.0702.v1

Impact of Covid-19 on Pharmacy Students in India

Nancy Goel, Irfanul Haque, Sarita Jangra Bhyan, Aashi Jain, Amrita Kumari, Kulsoom Hamid, M. Sreelakshmi, Besty Thomas, Rashi Chauhan

Subject: Medicine And Pharmacology, Pharmacy Keywords: Coronavirus; Lockdown; Pandemic; Survey; Students; WHO

Online: 29 July 2020 (17:35:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201709.0154.v1

A Molecular Interpretation on the Different Penetration Enhancement Effect of Borneol and Menthol towards 5-FU

Ran Wang, Zhimin Wu, Shufang Yang, Shujuan Guo, Xingxing Dai, Yanjiang Qiao, Xinyuan Shi

Subject: Medicine And Pharmacology, Pharmacy Keywords: penetration enhancement effect; molecular mechanism; coarse grain molecular dynamics; menthol; borneol; 5-FU

Online: 29 September 2017 (12:39:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0448.v1

Phenotypic Assays for Detection of Extended Spectrum Β-Lactamases and Carbapenemases: A Laboratory Guide for Microbiologists

Dickson Aruhomukama

Subject: Medicine And Pharmacology, Pharmacy Keywords: Extended spectrum β-lactamases, AmpC Carbapenemases, Carbapenemases, Classification, Phenotypic Detection, Clinically significant bacteria

Online: 24 September 2018 (08:57:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0008.v1

KERRA, Mixed Medicinal Plant Extracts, Inhibits SARS-CoV-2 Targets Enzymes and Feline Corona Virus

Supaphorn Seetaha, Phatcharin Khamplong, Panatda Wanaragthai, Thitinan Aiebchun, Siriluk Ratanabunyong, Sucheewin Krobthong, Yodying Yingchutrakul, Jatuporn Rattanasrisomporn, Kiattawee Choowongkomon

Subject: Medicine And Pharmacology, Pharmacy Keywords: COVID-19 pandemic; KERRA; SARS-CoV-2 main protease; RNA-dependent RNA polymerase; anti-FIPV activity

Online: 1 April 2022 (14:53:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0106.v1

The Diagnostic Value of HIF-2 Alpha to Determine The Development and Efficacy of Treatment for Contrast Induced Nephropathy: An Experimental Study

Ismail Altintop, Mehmet Tatli, Cigdem Karakukcu, Zeynep Soyer Sarica, Arzu Hanım Yay, Esra Balcioglu, Ahmet Ozturk

Subject: Medicine And Pharmacology, Pharmacy Keywords: contrast-induced nephropathy; hypoxia-inducible factor 2α; N-acetyl-cysteine; sildenafil

Online: 7 May 2018 (08:15:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints201805.0315.v1

Future Prospects for Neisseria gonorrhoeae Treatment

Beatriz Suay-García, María Teresa Pérez-Gracia

Subject: Medicine And Pharmacology, Pharmacy Keywords: Neisseria gonorrhoeae; antibiotic resistance; gonorrhea; treatment

Online: 23 May 2018 (07:46:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0163.v2

Monitoring Antibiotics and Inflammatory Markers in Human Blood: Impact in Choice of Antibiotic Therapy and Used Methods

Anna N. Berlina, Anatoly V. Zherdev, Boris B. Dzantiev

Subject: Medicine And Pharmacology, Pharmacy Keywords: individual therapy; metabolism of antibiotics; dosage choice; inflammation; biomarkers

Online: 16 December 2019 (11:25:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202108.0512.v1

In-silico Study Of Oyster Mushroom (Pleurotus Ostreatus ) Targeting PARP Protein (4UND)

Kajal Nadaf, Pravin Badhe

Subject: Medicine And Pharmacology, Pharmacy Keywords: oyster mushroom (Pleurotus sp.); PARP protein; 4UND protein; molecular docking; PyRx; BIOVIA drug discovery

Online: 26 August 2021 (16:15:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201911.0163.v1

Monitoring Antibiotics and Inflammatory Markers in Human Blood: Impact in Choice of Antibiotic Therapy and Used Methods

Anna N. Berlina, Anatoly V. Zherdev, Boris B. Dzantiev

Subject: Medicine And Pharmacology, Pharmacy Keywords: individual therapy; metabolism of antibiotics; dosage choice; inflammation; biomarkers

Online: 14 November 2019 (11:27:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0483.v1

Multiplex-Heterogeneous Network Embedding for Drug Repositioning

Léo Pio-Lopez

Subject: Medicine And Pharmacology, Pharmacy Keywords: Network embedding; multiplex-heterogeneous network; multi-layer network; drug repositioning; graph representation learning

Online: 19 April 2021 (13:21:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.2007.v1

Parenteral Ready-to-Use Fixed-Dose Combinations of NSAIDs for Multimodal Analgesia – An overview of approved products and challenges

Fernando Silva, Gustavo Costa, Francisco Veiga, Catarina Cardoso, Ana Cláudia Paiva-Santos

Subject: Medicine And Pharmacology, Pharmacy Keywords: fixed-dose combination; NSAID; ready-to-use; parenteral; multimodal analgesia; pain

Online: 29 May 2023 (10:05:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0424.v1

Genistein Loaded Nanofibers Protect Spinal Cord Tissue Following Experimental Injury in Rats

Mohamed Ismail, Sara Ibrahim, Azza Elamir, Amira M. Elrafei, Nageh Allam, Ahmed Abdellatif

Subject: Medicine And Pharmacology, Pharmacy Keywords: Genistein; nanofibers; spinal cord injury; inflammation; SOD; NO; MDA; IL-10; TNF-α

Online: 20 September 2018 (17:11:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202309.1452.v1

The Use of Microfluidic Systems for Nanoparticle Production

Aysenur Bezelya, Berrin Kucukturkmen, Asuman Bozkır

Subject: Medicine And Pharmacology, Pharmacy Keywords: microfluidic system; nanoparticle; lipid-based nanoparticles; polymeric nanoparticles

Online: 21 September 2023 (05:03:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0047.v1

Direct Quantification by Infrared Spectroscopy of Drug Loading Content in Polymeric Nanoparticles

Guzmán Carissimi, Mercedes G. Montalbán, Gloria Víllora, Andreas Barth

Subject: Medicine And Pharmacology, Pharmacy Keywords: silk fibroin; nanoparticles; drug loading content; quantification; infrared spectroscopy; FTIR spectroscopy.; nanotechnology; nanomedicine; drug delivery; controlled release

Online: 3 September 2020 (03:56:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0275.v1

Big Data Approach to Large Scale Molecular Dynamics Simulations: Necessity and Inevitability for Drug Design

Dheeraj Chitara, Sanjeev B. S.

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cloud infrastructure; Spark; Molecular Dynamics simulations; Drug design.

Online: 16 September 2021 (11:02:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202212.0463.v1

Core -Shell Particles: from Fabrication Methods to Diverse Manipulation Techniques

Ajeet Singh Yadav, Du Tuan Tran, Adrian J. T. Teo, Yuchen Dai, Fariba Malekpour Galogahi, Nam-Trung Nguyen, Chin Hong Ooi

Subject: Medicine And Pharmacology, Pharmacy Keywords: Core shell particles; digital microfluidics

Online: 26 December 2022 (02:51:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202006.0174.v1

A Systematic Review of Implications, Mechanisms, and Stability of In Vivo Emergent Resistance to Colistin and Tigecycline in Acinetobacter baumannii

Stamatis Karakonstantis

Subject: Medicine And Pharmacology, Pharmacy Keywords: Acinetobacter baumannii; colistin; tigecycline; resistance; in vivo

Online: 14 June 2020 (14:16:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0015.v1

Computational Screening of Molecules Approved in Phase-I Clinical Trials to Identify 3CL Protease Inhibitors to Treat COVID-19

Kamlesh Sahu, Jack Tuszynski, Michael Houghton, Lorne Tyrrell, Sergei Noskov

Subject: Medicine And Pharmacology, Pharmacy Keywords: virtual screening; COVID-19; Protease 3CL pro

Online: 2 April 2020 (11:31:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1378.v1

Recent Advance Bakuchiol Application as a Potential Alternative to Retinol in Skincare and Cosmetics

Norisca Aliza Putriana, Patihul Husni, Soraya Ratnawulan Mita

Subject: Medicine And Pharmacology, Pharmacy Keywords: Bakuchiol; anti-aging; anti-hyperpigmentation; anti-oxidant; anti-inflammatory; anti-acne; and anti-melanogenesis

Online: 18 January 2024 (07:23:52 CET)

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Preprint REVIEW | doi:10.20944/preprints202304.0180.v1

Current Status and Future Perspectives of Antibiotic Therapy for MRSA Infections

Nooh Mohamed Hajhamed, Abualgasim Elgaili Abdalla, Salahdeen Ismail Mohammed, Abdallah Elssir Ahmed, Abdullah M. Bakheit, Abubakar Abdelbagi, Mohamed Sir Elkhatim Ali, Rihab Ali Omer, Emmanuel Edwar Siddig, Ayman Ahmed, Nouh Saad Mohamed

Subject: Medicine And Pharmacology, Pharmacy Keywords: Methicillin-resistant Staphylococcus aureus; MRSA; antibiotic resistance mechanism; novel therapeutic approaches

Online: 11 April 2023 (03:20:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0980.v1

Qualitative and Quantitative Analysis of Selected Antibiotics Used in Djibouti Hospitals

abdirahman elmi fourreh, fatouma Mohamed abdoul-Latif, Chayma MOUTI

Subject: Medicine And Pharmacology, Pharmacy Keywords: Analysis; antibiotic; Djibouti; HPLC; spectrophotometer; TLC

Online: 17 November 2023 (07:56:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201905.0165.v2

Geospatial-Temporal and Demand Models for Opioid Admissions, Implications for Policy

Lawrence Fulton, Zhijie Dong, Benjamin Zhan, C. Scott Kruse, Paula Stigler Granados

Subject: Medicine And Pharmacology, Pharmacy Keywords: opioids, GIS, random forests

Online: 18 June 2019 (11:15:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0165.v1

Geospatial-Temporal and Demand Models for Opioid Admissions, Implications for Policy

Lawrence Fulton, Zhijie Dong, Benjamin Zhan, Clemens Scott Kruse, Paula Stigler Granados

Subject: Medicine And Pharmacology, Pharmacy Keywords: opioids, GIS, random forests

Online: 13 May 2019 (14:36:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0138.v1

In-silico study of Agaricus Bisporus on DNA damaging protein

Sanket Shelke, Pravin Badhe

Subject: Medicine And Pharmacology, Pharmacy Keywords: Agaricus Bisporus; Button Mushroom; Molecular docking; PyRx software; BIOVIA Discovery studio

Online: 8 September 2021 (10:14:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0440.v1

Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation

Marcus J.C. Long, Pierre A. Miranda Herrera, Yimon Aye

Subject: Medicine And Pharmacology, Pharmacy Keywords: electrophiles; signaling; profiling; drug mechanism; drug discovery; T-REX

Online: 28 January 2022 (14:57:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202305.1605.v1

Development and Evaluation of Apocynin Loaded pH-sensitive Nanoparticle Based Hydrogel for the Management of Rheumatoid Arthritis

Rasikha Akbar, Dildar Khan, Muhammad Bilal Sabir, Irfan Shaukat, Irfa Basharat Rajpoot, Asim Ur Rehman, Naz Dilawar, Shefaat Ullah Shah, Asif Nawaz, Faiqa Falak Naz, Saima Mehmood, Hafiz Muhammad Basit, Suliman Yousef Alomar, Kifayat Ullah Shah

Subject: Medicine And Pharmacology, Pharmacy Keywords: pH sensitive Polymer; Methacrylate Polymers; Eudragit L100; Polymeric nanoparticles; Apocynin; Rheumatoid arthritis; Carbopol-934 based Hydrogel; Transdermal Drug Delivery System

Online: 23 May 2023 (07:51:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202103.0387.v1

Inclusion Complex of Iloperidone with Sulfobutyl Ether Beta-Cyclodextrin: Characterization and Dissolution Studies

Rupali Sanjay Bhadale, Vaishali Yogesh Londhe

Subject: Medicine And Pharmacology, Pharmacy Keywords: β-cyclodextrin; binary complex; antipsychotic drug; dissolution studies

Online: 15 March 2021 (13:44:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0180.v1

Investigation of Cytotoxicity and Cell Uptake of Cationic Beta-Cyclodextrins as Valid Tools in Nasal Delivery

Giovanna Rassu, Silvia Fancello, Marta Roldo, Milo Malanga, Lajos Szente, Rossana Migheli, Elisabetta Gavini, Paolo Giunchedi

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cationic cyclodextrin; cyclodextrin polymer; epichlorohydrin cross-linker; nasal delivery; cytotoxicity; cell uptake

Online: 9 July 2020 (08:05:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0470.v1

Development and Characterization of Chitosan-Based Spray-Dried Solid Dispersions of Apigenin: 3D Printed Shell-Pill for Improved Efficacy of Model Flavonoid

Amer S Alali, Muqtader Ahmed, Farhat Fatima, Md Khalid Anwer, Mutasim Ibnauf, Jamel Patel

Subject: Medicine And Pharmacology, Pharmacy Keywords: Chitosan; Apigenin; Spray Dried Solid Dispersion; FTIR; DSC; XRD; SEM; 3D; Shell Pill

Online: 18 April 2023 (03:35:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0484.v1

Phytochemical Compounds Involved in the Bone Regeneration Process and Their Innovative Administration: A Systematic Review

Alina Hanga-Farcaș, Florina Miere(Groza), Gabriela Adriana Filip, Simona Clichici, Luminița Fritea, Laura Vicaș, Eleonora Marian, Annamaria Pallag, Tunde Jurca, Sanda Monica Filip, Mariana Eugenia Mureșan

Subject: Medicine And Pharmacology, Pharmacy Keywords: bone regeneration; bone cells; bone biomarkers; bone signaling pathways; plants extracts; phytochemicals compounds; nanometric systems; nanostructured scaffolds

Online: 18 April 2023 (04:41:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0953.v1

Cyclodextrins Inclusion Complexes Improving Antibacterial Drug Profiles: An Update Systematic Review

Anamaria Mendonça Santos, José Adão Carvalho Do Nascimento Júnior, Silvia Vitória Silva Cézar, Lucindo José Quintans Júnior, Adriano Antunes de Souza Araújo, Diana Marcela Aragón, Mairim Russo Serafini

Subject: Medicine And Pharmacology, Pharmacy Keywords: Antibacterial Agents; Antibiotics; Cyclodextrins; Inclusion Complex; Technology; Treatments

Online: 26 April 2023 (04:09:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2139.v1

Screening of Antibacterial and Antibiofilm Activities of Commercially Available Essential Oils' Different Samples in Comparison to Conventional Antibiotics

Răzvan Neagu, Violeta Popovici, Lucia-Elena Ionescu, Viorel Ordeanu, Diana Mihaela Popescu, Emma Adriana Ozon, Cerasela Elena Gird

Subject: Medicine And Pharmacology, Pharmacy Keywords: Origani aetheroleum; Eucalypti aetheroleum; Rosmarini aetheroleum; Caryophylli aetheroleum; Menthae aetheroleum; antibacterial activity; antibiofilm effectiveness

Online: 30 May 2023 (12:34:34 CEST)

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Essential oils (EOs) have gained economic importance due to their biological activities, and increasing amounts are demanded everywhere. However, substantial differences between the same essential oil samples from different suppliers are reported due to numerous companies involved in EOs production and the continuous development of online sales. The present study investigates the antibacterial and antibiofilm activities of 2-4 samples of five commercially available essential oils (Oregano, Eucalyptus, Rosemary, Clove, and Peppermint oils) from different manufacturers. Their effects were evaluated in vitro on Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa). The antibacterial efficacy (ABE%) and antibiofilm efficacy (ABfE%) were determined spectrophotometrically at 562 and 570 nm using microplate cultivation techniques. The essential oils' calculated parameters were compared with those of three standard broad-spectrum antibiotics: Amoxicillin/Clavulanic acid (AMC), Gentamycin (GEN), and Streptomycin (STR), active on tested bacteria. The results showed that at the first dilution (D1 = 2.5 mg/mL), all essential oils (EOs) exhibited antibacterial activity against Gram-positive and Gram-negative bacteria. On S. aureus and E. coli, EOs had considerable antibacterial effects (ABE = 79.70—92.80%, respectively, 71.30 ‒ 94.00%). The highest antibacterial effects of commercially available EOs were against P. aeruginosa because all exhibited a significant antibiofilm activity. Their antibiofilm efficacy intensively decreased on E. coli and S. aureus. Generally, the samples with different manufacturers of the same EO showed similar effects. Only Clove and Peppermint oils samples displayed a higher variability associated with active metabolites' different contents, maybe due to various zones of harvesting raw material, numerous technologies involved in EOs obtaining processes, and complex interactions between components.

Preprint REVIEW | doi:10.20944/preprints202307.1964.v1

Cost-effectiveness of Glucosamine in Osteoarthritis Treatment: A Systematic Review

Nam Xuan Vo, Ngan Nguyen Hoang Le, Trinh Dang Phuong Chu, Huong Lai Pham, Khang Xuan An Dinh, Uyen Thi Thuc Che, Thanh Thi Thanh Ngo, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: economic evaluation; cost-effectiveness; glucosamine; osteoarthritis; systematic review

Online: 28 July 2023 (11:25:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.1108.v1

Biopolymer-Based Nanogel Approach in Drug Delivery: Basic Concept and Current Developments

Ebru Altuntaş, Burcu Özkan, Sevgi Güngör, Yıldız Özsoy

Subject: Medicine And Pharmacology, Pharmacy Keywords: biopolymers; nanogels; drug delivery; polysaccharide-based nanogels; protein-based nanogels; nanotechnology

Online: 28 April 2023 (04:32:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.1384.v1

Inorganic Compounds Used in Cancer Treatment

Ioana Babarus, Ionut-Iulian Lungu, Denisa Florina Diaconu, Alina Stefanache

Subject: Medicine And Pharmacology, Pharmacy Keywords: cancer; cisplatin; selenium; zinc

Online: 20 June 2023 (04:26:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1678.v1

Economic Evaluation of Glucosamine in Knee Osteoarthritis Treatments in Vietnam

Nam Xuan Vo, Uyen Thi Thuc Che, Thanh Thi Thanh Ngo, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: Economic evaluation; Cost-utility analysis; Glucosamine; Knee Osteoarthritis; Vietnam

Online: 25 July 2023 (09:18:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0964.v1

Chemistry and Pharmacology of Delta-8-Tetrahydrocannabinol

Maged S. Abdel-Kader, Mohamed M. Radwan, Ahmed M. Metwaly, Ibrahim H. Eissa, Arno Hazekamp, Mahmoud A. ElSohly

Subject: Medicine And Pharmacology, Pharmacy Keywords: Δ 8-THC; isolation; chemistry; analysis; pharmacology

Online: 19 February 2024 (11:49:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.0136.v1

Parametric Optimization in 3D Printed Tablets Using Statistical Methods of Experimental Design

Emma Adriana Ozon, Adina Magdalena Musuc, Iulian Sarbu, Violeta Popovici, Anca Lucia Pop, Dumitru Lupuliasa

Subject: Medicine And Pharmacology, Pharmacy Keywords: 3D printing; oblong tablets; statistical methods; parametric optimization

Online: 2 June 2023 (07:41:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0475.v2

Effectiveness and Safety of Glucosamine in Osteoarthritis: A Literature Review

Nam Xuan Vo, Ngan Nguyen Hoang Le, Trinh Dang Phuong Chu, Huong Lai Pham, Khang Xuan An Dinh, Uyen Thi Thuc Che, Thanh Thi Thanh Ngo, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: Osteoarthritis; Effectiveness; Safety; Glucosamine; systematic review

Online: 7 June 2023 (10:08:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0609.v1

Phytochemical and Pharmacological Research of the American Cranberry (Oxycoccus macrocarpus (Ait.) Pursh) Leaves Extract and its Aminoacids Preparation with Hepatoprotective Activity

Oleh Коshovyi, Inna Vlasova, Valdas Jakstas, Gabriele Vilkickyte, Vaidotas Žvikas, Roman Hrytsyk, Lyubov Grytsyk, Ain Raal

Subject: Medicine And Pharmacology, Pharmacy Keywords: American cranberry (Oxycoccus macrocarpus); leaves; extract; modification; amino acid; hepatoprotective activity.

Online: 20 April 2023 (05:28:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0204.v1

Development and Validation of a Digital Image Processing-Based Pill Detection Tool for an Oral Medication Self-Monitoring System

Jannis Holtkötter, Rita Amaral, Rute Almeida, Cristina Jácome, Ricardo Cardoso, Ana Pereira, Mariana Pereira, Ki Chon, João Almeida Fonseca

Subject: Medicine And Pharmacology, Pharmacy Keywords: computer vision; image processing; medication adherence; object detection; pill detection

Online: 17 February 2022 (08:45:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0202.v1

3D Printing of Personalised Carvedilol Tablets Using Selective Laser Sintering

Dennis Douroumis, Atabak Ghanizadeh Tabriz, Quentin Gonot-Munck, Arnaud Baudoux, Vivek Garg, Richard Farnish, Orestis Katsamenis, Hui Ho-Wah, Nathan Boersen, Sandra Roberts, John Jones

Subject: Medicine And Pharmacology, Pharmacy Keywords: 3D printing; selective laser sintering; personalised medicines; oral; carvedilol

Online: 5 July 2023 (02:21:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints202307.2046.v1

An Updated Review of Developing Small Molecule Kinase Inhibitors Using Computer-Aided Drug Design Approaches

Linwei Li, Songtao Liu, Bi Wang, Fei Liu, Shu Xu, Pirui Li, Yu Chen

Subject: Medicine And Pharmacology, Pharmacy Keywords: CADD; SBDD; LBDD; kinase; small molecule kinase inhibitors

Online: 31 July 2023 (03:05:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202312.1067.v1

European Association of Hospital Pharmacists (EAHP) Guidance on the Pharmacy Handling of In Vivo Gene Therapy Medicinal Products

Joan VINENT GENESTAR, Sylvain Auvity, Nanna Christiansen, Heidi Ekelund, Liesbeth Huys, Helle Bach Ølgaard McNulty, Marcello Pani, Vera Pires, Bertrand Pourroy, Nicola Stoner

Subject: Medicine And Pharmacology, Pharmacy Keywords: Genetic therapy; Pharmaceutical preparations; Pharmacy service, hospital; Safety; Practice guideline. ;

Online: 14 December 2023 (08:29:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0260.v1

The Effect of Edge Activator Combinations using a Langmuir Technique in Transethosomal Formulations for Skin Delivery of Thymoquinone

Hana Mohd, Katarzyna Dopierała, Anže Zidar, Amitkumar Virani, Bożena Michniak-Kohn

Subject: Medicine And Pharmacology, Pharmacy Keywords: thymoquinone; transethosomes; ethosomes; langmuir study transdermal

Online: 5 October 2023 (08:14:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202307.1054.v1

Brain-Derived Reconstituted Lipid Nanoparticles Show Selective Homing to Ischemic Brain

Dan Han, Cheng Wang

Subject: Medicine And Pharmacology, Pharmacy Keywords: reconstituted lipid nanoparticles; selective homing; ischemic stroke

Online: 17 July 2023 (10:46:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0692.v1

Gastroplus and HSPiP Oriented Predictive Parameters as the Basis of Valproic Acid Loaded Mucoadhesive Cationic Nanoemulsion Gel for Improved Nose-To-Brain Delivery to Control Convulsion in Human

Afzal Hussain, Mohammad A. Altamimi, Mohd Aamir Mirza, Mohhammad Ramzan, Tahir Khuroo

Subject: Medicine And Pharmacology, Pharmacy Keywords: Valproic acid; GastroPlus based prediction; Cationic nanoemulsion; Gels; In vitro– ex vivo permeation profile; CLSM study

Online: 9 June 2023 (09:20:55 CEST)

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Oral and parenteral delivery of first-line anticonvulsant Valproic cid (VA) are associated with serious adverse effects, high hepatic metabolism, high clearance, and low bioavailability in brain. GastroPlus program was used to predict in vivo performance of immediate (IR) and sustained release (SR) products in human. HSPiP software predicted excipients with maximum possible miscibility of the drug. Based on GastroPlus and HSPiP program, various excipients were screened for experimental solubility study and prepared cationic nanoemulsions and respective gels for nasal to brain delivery. These were characterised for size, size distribution, polydispersity index, zeta potential, morphology, pH, % transmittance, drug content, and viscosity. In vitro drug release, ex vivo permeation profile (goat nasal mucosa), and penetration studies were conducted. Result showed that in-vivo oral drug dissolution and absorption were predicted as 98.6 mg and 18.8 mg, respectively from both tablets (IR and SR) at 8 h using GastroPlus. The drug access to the portal vein was relatively predicted high in IR (115 mg) as compared to SR (82.6 mg). Plasma drug concentration-time profile predicted was in good agreement with published reports. The program predicted duodenum and jejunum as the prime site of drug absorption and no effect of nanonization on Tmax for sustained release formulation. Hansen parameters suggested suitable selection of excipients. The program recommended for nasal to brain delivery of the drug using cationic mucoadhesive product. The optimized stable CVE6 was associated with optimal size (113 nm), low PDI (0.26), high zeta potential (+34.7 mV), high transmittance (97.8%), and high strength (0.7 %w/w). In vitro release and ex vivo permeation of CVE6 were found to be substantially high as compared to anionic AVE6 and respective gels. Penetration study executed high fluorescence intensity with CVE6 and CVE6-gel as compared to suspension and ANE6 which may be attributed to electrostatic interaction between mucosal membrane and nanoglobules. Thus, cationic nanoemulsion and respective mucoadhesive gel are promising strategy for delivery of VA to brain through intransal administration for the treatment of seizure and convulsion.

Preprint ARTICLE | doi:10.20944/preprints202306.0038.v1

Virtual Screening of a Series of Phytocompounds from Lagenaria Siceraria for the Identification of Potential Antidiabetic Drug Candidates, in Silico Study and Drug Design Approaches

Arifa Sultana, Fabiha Noushin, Md. Liakot Ali, Md. Zakir Sultan, Jakir Ahmed Chowdhury, Abu Asad Chowdhury, Shaila Kabir, Md. Shah Amran

Subject: Medicine And Pharmacology, Pharmacy Keywords: Lagenaria siceraria; In silico study; Drug design; Diabetes mellitus; Molecular docking; ADMET

Online: 1 June 2023 (05:41:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0997.v1

An Integrated Computational and Experimental Approach to Formulate Tamanu Oil Bigels as Anti-Scarring Agent

Megha Krishnappa, Sindhu Abraham, Sharon Caroline Furtado, Shwetha Krishnamurthy, Aynul Rifaya, Kumarappan Chidamabaram, Parasuraman Pavadai

Subject: Medicine And Pharmacology, Pharmacy Keywords: Bigel; Calophyllum inophyllum; Calanolide A; Piscean collagen; Tamanu oil; Molecular Docking; ADMET

Online: 14 August 2023 (08:47:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.1844.v1

Incompatibility of Y-Site Administered Drugs: the Case of Acyclovir and Ciprofloxacin

Dorine Labrosse, Lugan Flacher, Thomas Bachelart, Ahcène Boumendjel

Subject: Medicine And Pharmacology, Pharmacy Keywords: drugs incompatibility; drugs interactions; acyclovir; ciprofloxacin

Online: 27 September 2023 (10:57:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1574.v1

Cost-Utility of Monulpiravir in COVID-19 Treatment: An Estimation in Vietnam Situation

Nam Xuan Vo, Ngan Nguyen Hoang Le, Trinh Dang Phuong Chu, Huong Lai Pham, Khang Xuan An Dinh, Tu Kim Tran, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cost-utility; Covid-19; Molnupiravir; Vietnam; Utility

Online: 21 June 2023 (15:34:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0938.v1

Exosomes: Potential Next-Generation Nanocarriers for the Therapy of Inflammatory Diseases

Tosca Mori, Lisa Giovannelli, Anna Rita Bilia, Francesca Margheri

Subject: Medicine And Pharmacology, Pharmacy Keywords: extracellular vesicles; exosomes; chemical composition; miRNA; nanocarriers; inflammation; neurological diseases; liver; kidney and lung injuries; rheumatoid arthritis and osteoarthritis; intestinal bowel diseases

Online: 14 August 2023 (05:22:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1227.v1

Ameliorative Effect of Ethanolic Extract of Moringa oleifera Leaves in Combination with Curcumin against PTZ Induced Kindled Epilepsy in rats; In Vivo and In Silico Study

Md. Niyaz Alam*, Lubhan Singh, Najam Ali Khan, Yahya I. Asiri, Mohd. Zaheen Hassan, Obaid Afzal, Abdulmalik Saleh Alfawaz Altamimi, Md. Sarfaraj Hussain

Subject: Medicine And Pharmacology, Pharmacy Keywords: Moringa oleifera; curcumin, neuroprotective, pentylenetetrazole, oxidative stress.

Online: 16 June 2023 (11:00:33 CEST)

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Preprint REVIEW | doi:10.20944/preprints202402.0458.v1

Potential Drug Interactions with Cannabinoids in Selected Chronic Diseases: Epilepsy, Autism Spectrum Disorders, Oncology, Multiple Sclerosis and Pain

Maria Graça Campos, Maria China, Mariana Claudio, Miguel Capinha, Rita Torres, Simao Oliveira, Ana Fortuna

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cannabinoids; Tetrahydrocannabinol; CBD; Drug-drug Interactions; F.I.R.E.S.; Cytochrome P450; Epilepsy; Cancer; Autism Spectrum Disorder

Online: 7 February 2024 (17:38:44 CET)

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Preprint REVIEW | doi:10.20944/preprints202310.1518.v1

Exploring the Potential of Using Marine-Derived Ingredients: From the Extraction to Cutting-Edge Cosmetics

João Pedro Costa, Luisa Custódio, Catarina Pinto Reis

Subject: Medicine And Pharmacology, Pharmacy Keywords: cosmetics; marine; extracts; algae; blue biotechnology; sustainability

Online: 24 October 2023 (10:30:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.1553.v1

Anti-Cancer and Anti-Diabetics Potentials of Punicalagin Derivatives Extracted from Peeled of Pomegranate (Punica granatum)

Sabina Yasmin, Ajay Kumar Yadav, Rosolonjatovo Heriniavo Michael, Shabana Khatun, Sarthak Chauhan, Manoj Kurmi, Simranjit Kaur, Nazima Haider, Ajay Kumar Sah, Akash Kumar, Sumeet Gupta, Pritam Singh, Kavita Munjal, Mohammad Yousuf Ansari

Subject: Medicine And Pharmacology, Pharmacy Keywords: Punicalagin; hepatoprotective; polyphenols

Online: 22 August 2023 (10:10:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.0061.v1

A New In Vivo Method for the Determination of α-Glucosidase Inhibition in Natural Products as Treatment for Diabetes Mellitus Type II

María Pilar De Torre, Jose Luis Vizmanos, Rita Yolanda Cavero, María Isabel Calvo

Subject: Medicine And Pharmacology, Pharmacy Keywords: C. elegans; hyperglycemia; O. vulgare; in vitro digestion

Online: 2 August 2023 (04:59:16 CEST)

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Background: One of the main diseases of worldwide concern is non–insulin dependent Diabetes mellitus. 90-95% of patients with diabetes suffers from Type II diabetes, a metabolic diabetes whose prevalence is increasing in the world.Given the current prevalence of diabetes type II in society, research of natural compounds able to regulate glycaemia and insulin–resistance is nowadays covering importance, as alternative or co–adjuvant treatment to existing hypoglycaemic medicines. In pre–clinical steps of research, C. elegans is considered a promising in vivo model for the study of the molecular mechanism of glucose as part of anti–diabetic bioactivity.Most of the studies of insulin resistance with this in vivo model are carried out by using mutant strains such as daf-2 and the effects of the compounds are attributed a posteriori, after a physiological response of the worms rather than directly measuring preservation of activity inside the worm. Methods: The in vitro α-glucosidase inhibition of two oral formulations with Origanum vulgare extract before and after a simulated process of gastrointestinal digestion was evaluated. After confirming the in vitro activity, the α-glucosidase inhibition was tested in vivo through the new method proposed. Results: The crude extract showed an IC50 value similar to acarbose (positive control), before and after the gastrointestinal digestion. The encapsulated extract (111.86±1.25 µg/mL) did not present statistical differences with the positive control (110.10±1.15 µg/mL) after digestion. However, the powder formulation showed the highest hypoglycaemic activity (59.55±0.85 µg/mL).In vivo, the IC50 values showed similar profile than in vitro. Conclusion: A new simple and reliable method has been developed to determine pharmacological activities inside in vivo model C. elegans.The method has been evaluated with a hydroalcoholic extract of O. vulgare. The method is accurate and valid for the quantification of the inhibition of in vivo, allowing the direct attribution of this in vivo hypoglycaemic activity to the treatment. In addition, it opens the door to further research into in vitro pharmacological activities that require an in vivo counterpart.

Preprint ARTICLE | doi:10.20944/preprints202306.0847.v1

A Novel UHPLC-MS/MS Based Bioanalytical Method Used for S-Allyl Cysteine Comparative Pharmacokinetic Study

Niyaz Ahmad, Mohd Faiyaz Khan, Faisal K Alkholifi, Zabih Ullah, Sadaf Farooqui, Dr. Nazia Khan, Mohammed Saifuddin Khalid, Mir Naiman Ali, Hajera Tabassum

Subject: Medicine And Pharmacology, Pharmacy Keywords: S-Allyl Cysteine; Oral Bioavailability; PLGA NPs; LC–MS/MS; Pharmacokinetics

Online: 12 June 2023 (14:09:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0232.v1

Adherence to Prescribing Indicators at a District Hospital in Ghana: Do We Match WHO Standards?

Obed Kwabena Offe Amponsah, Nana Kwame Ayisi-Boateng, Sharath Burugina Nagaraja, Divya Nair, Karlos Muradyan, George Kwesi Hedidor, Appiah-Korang Labi, Mercy Naa Aduele Opare-Addo, Emmanuel Sarkodie, Kwame Ohene Buabeng

Subject: Medicine And Pharmacology, Pharmacy Keywords: Drug use review; Outpatients; Ghana; SORT IT; Quality indicators; Electronic Medical Records; Operational research; Rational use of medicines

Online: 15 September 2022 (13:39:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.0859.v1

Clinical Relevance of Drug Interactions in People Living with Human Immunodeficiency Virus on Antiretroviral Therapy - Update 2022: Systematic Review

Pedro Amariles, Monica Rivera-Cadavid, Mauricio Ceballos

Subject: Medicine And Pharmacology, Pharmacy Keywords: drug interactions; antiretroviral agents; HIV/AIDS

Online: 12 June 2023 (16:44:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0130.v1

Pharmaceutical Evaluation of Levofloxacin Orally Disintegrating Tablet Formulation Using Low Frequency Raman Spectroscopy

Yoshihisa Yamamoto, Mizuho Kajita, Yutaro Hirose, Naoki Shimada, Toshiro Fukami, Tatsuo Koide

Subject: Medicine And Pharmacology, Pharmacy Keywords: levofloxacin; orally disintegrating tablet; crystalline form; low frequency Raman spectroscopy

Online: 2 June 2023 (04:37:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0406.v1

Developing a Tool for Auditing the Quality of Antibiotic Dispensing in Community Pharmacies: A Pilot Study

Maarten Lambert, Ria Benkő, Athina Chalkidou, Jesper Lykkegaard, Malene Plejdrup Hansen, Carl Llor, Pia Touboul Lundgren, Indrė Trečiokienė, Maria-Nefeli Karkana, Anna Kowalczyk, Katja Taxis

Subject: Medicine And Pharmacology, Pharmacy Keywords: community pharmacy practice; dispensing quality; antibiotics; antimicrobial resistance; Audit Project Odense

Online: 27 September 2022 (03:26:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.0147.v1

Phytochemistry and biological activities of Cissus trifoliata against carcinomas

Luis Fernando Méndez-López

Subject: Medicine And Pharmacology, Pharmacy Keywords: Cissus sp., Phytochemicals, Apoptosis, Proliferation, EMT, Anticancer

Online: 3 January 2024 (05:35:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202312.2064.v1

A New Frontier in Hypertension Management: Formulating and Characterizing Subcutaneous Implants using Hot Melt Extrusion

Kshitij Chitnis, Nagarjuna Narala, Sagar Narala, Siva Ram Munnangi, Sateesh Kumar Vemula, Michael A Repka

Subject: Medicine And Pharmacology, Pharmacy Keywords: Hypertension, Subcutaneous Implants, Hot Melt Extrusion, Controlled Drug Delivery, Biodegradable, Implantable Drug Delivery

Online: 27 December 2023 (09:45:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0554.v1

The Role of Biodegradable Polymers in Nano Carrier-based Drug Delivery System to Enhance Oral Bioavailability & Solubility of BCS Class II, IV Drugs: A Review

Mohan Tripathi, Peeyush Bhardwaj, Shruti Tiwari, Arti Sahu

Subject: Medicine And Pharmacology, Pharmacy Keywords: Biodegradable Polymers; Nanotechnology; Drug Delivery &; Drug Development

Online: 8 January 2024 (06:50:25 CET)

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Preprint ARTICLE | doi:10.20944/preprints202304.0696.v1

Synthesis, Biophysical Properties, and Antitumor Activity of Antisense Oligonucleotides Conjugated with Anisamide

Zhe Zhang, Zuyi Chen, Zhenyu Xiao, Yuan Luo, Xiaochen Pan, Liang Xu, Xuesong Feng

Subject: Medicine And Pharmacology, Pharmacy Keywords: oligonucleotide conjugation; anisamide; anti-enzymatic stability; cellular uptake; antitumor activity

Online: 21 April 2023 (08:53:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202308.0690.v1

The Importance of Antioxidant Activity for the Health-Promoting Effect of Lycopene

Anna Kulawik, Judyta Cielecka-Piontek, Przemysław Zalewski

Subject: Medicine And Pharmacology, Pharmacy Keywords: lycopene; neuroinflammation; neurodegenerative diseases

Online: 8 August 2023 (14:49:48 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1939.v1

Systematic Review of Chemical and Biological Activity Studies of Extracts and Isolated Compounds From Nudibranchs

Neide M. M. Epifanio, Raquel Rennó Braga, Raul Rennó Braga, Vitoria Oliveira Silva, Nayana F Pereira, Bianca Augusto de Souza, Davyson de Lima Moreira, Douglas S.A. Chaves

Subject: Medicine And Pharmacology, Pharmacy Keywords: marine pharmacognosy; natural products; nudibranch; terpenes; alkaloids

Online: 1 November 2023 (02:35:35 CET)

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Preprint REVIEW | doi:10.20944/preprints202306.0475.v1

Effectiveness and Safety of Glucosamine in Osteoarthritis: A Literature Review

Nam Xuan Vo, Ngan Nguyen Hoang Le, Trinh Dang Phuong Chu, Huong Lai Pham, Khang Xuan An Dinh, Uyen Thi Thuc Che, Thanh Thi Thanh Ngo, Tien Thuy Bui

Subject: Medicine And Pharmacology, Pharmacy Keywords: Osteoarthritis; Effectiveness; Safety; Glucosamine; systematic review

Online: 7 June 2023 (07:58:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202308.1201.v1

Antibacterial and Anti-quorum Sensing Activity of PAMAM G4 Loaded Quorum Quencher Peptide against MRSA, Staphylococcus aureus and Agr Mutants

Naifa A. Alenazi

Subject: Medicine And Pharmacology, Pharmacy Keywords: Methicillin-resistant Staphylococcus aureus; poly-amidoamine dendrimers (PAMAM); anti-virulence agent, accessory gene regulator; histidine kinase inhibitor.

Online: 16 August 2023 (20:32:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1164.v1

Construction of Different Oil Phases-Based Nanoemulsion Delivery Platform and Biodistribution Evaluation on Inflammatory Cells and Animal Models

Ying Chen, Huanhuan Liu, Yongyu Tang, Lidan Zhang, Xing jie Wu, Qian qian Guo, Yang Ding, Mao Chen Wei, Xiang Chun Shen, Ling Tao

Subject: Medicine And Pharmacology, Pharmacy Keywords: Inflammation; excipients; oil phases; nanoemulsion; distribution

Online: 16 May 2023 (11:44:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1363.v1

Treatment Advances for Acne Vulgaris: The Scientific Role of Cannabinoids

Inês Ferreira, Carla M. Lopes, Maria Helena Amaral

Subject: Medicine And Pharmacology, Pharmacy Keywords: acne vulgaris; cannabinoids; cannabidiol; sustainability; lipostatic; anti-inflammatory; antiproliferative; antimicrobial

Online: 18 January 2024 (04:49:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202307.0776.v1

Redox Modulatory Potential of Methanol Extract of Pentaclethra Macrophylla Stem Bark

Petra Obioma Nnamani, Edith Obioma Diovu, Peter Ikechukwu, Akachukwu M Onwuka, Obiora Emmanuel Abonyi, Obinna Chibueze Ibezim, Birgitta Loretz, Mariia Nesterkina, Claus- Michael Lehr

Subject: Medicine And Pharmacology, Pharmacy Keywords: Pentaclethera macrophylla stem bark; Methanol extract; Bergenin; Acute toxicity; Antioxidant; DPPH.

Online: 12 July 2023 (08:56:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0133.v1

Curcuminoids As Anticancer Drugs: Pleiotropic Effects In Vivo, Potential for Metabolic Reprogramming and Prospects for the Future

Daniel L. Pouliquen, Koraljka Gall Trošelj, Ruby John Anto

Subject: Medicine And Pharmacology, Pharmacy Keywords: curcuminoids; curcumin; cancer; signaling pathways; metabolic reprogramming; chemosensitization.

Online: 3 May 2023 (10:48:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1929.v1

Tween 80-Based Self-Assembled Mixed Micelles Boosted Valsartan Transdermal Delivery

Alaa Eldeen B. Yassin, Salam Massadeh, Abdullah A. Alshwaimi, Raslan H. Kittaneh, Mustafa E. Omer, Dilshad Ahmad, Alhassan H. Aodah, Faiyaz Shakeel, Majed A. Halwani, Saleh A. Alanazi, Prawez Alam

Subject: Medicine And Pharmacology, Pharmacy Keywords: Valsartan; Thin-film Hydration; Franz Diffusion Cell; Tween 80

Online: 30 October 2023 (11:44:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.0935.v1

Multifunctional Biotechnological Lip Moisturizer for Lip Repair and Hydration: Development, in vivo Efficacy Assessment and Sensory Analysis

Débora Dahmer, Sara Scandorieiro, Briani Gisele Bigotto, Thays Amélio Bergamini, Jennifer Germiani Cardozo, Isabela Mazarim Da Costa, Renata Katsuko Takayama Kobayashi, Gerson Nakazato, Dionísio Borsato, Sandra Helena Prudencio, Marina Leite Mitterer Daltoé, Maria Antonia Pedrine Colabone Celligoi, Audrey Alesandra Stinghen Garcia Lonni

Subject: Medicine And Pharmacology, Pharmacy Keywords: lip moisturizer; levana; sophorolipid; Citrus paradisi essential oil; bioimpedance; sensory attributes; acceptance; buy intention; cosmetics

Online: 16 October 2023 (08:17:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.1079.v1

Virtual Screening of Different Subclasses of Lignans with Anticancer Potential and Based on Genetic Profile

Mayara dos Santos Maia, Francisco Jaime Bezerra Mendonça-Junior, Gabriela Cristina Soares Rodrigues, Adriano Soares da Silva, Niara Isis Pereira de Oliveira, Pablo Rayff da Silva, Cícero Francisco Bezerra Felipe, Ana Pavla Almeida Diniz Gurgel, Anuraj Nayarisseri, Marcus Tullius Scotti, Luciana Scotti

Subject: Medicine And Pharmacology, Pharmacy Keywords: lignans; cancer; single nucleotide polymorphisms; virtual screening

Online: 16 June 2023 (05:10:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.1379.v1

Antimicrobial Susceptibility of Staphylococcus aureus to Anti-inflammatory Drugs With a Focus on the Combinatory Effect of Celecoxib With Oxacillin In Vitro

Onyedika Emmanuel Okpala, Johana Rondevaldova, Hayford Osei-Owusu, Tomas Kudera, Ladislav Kokoska

Subject: Medicine And Pharmacology, Pharmacy Keywords: antibacterial activity; antistaphylococcal synergistic effect; methicillin resistant S. aureus; musculoskeletal infections; non-steroidal anti-inflammatory drugs

Online: 22 November 2023 (06:33:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1626.v1

Antimicrobial Agent Against Methicillin-Resistant Staphylococcus Aureus Biofilm Monitored using Raman Spectroscopy

Young-Won Chin, Jina Kim

Subject: Medicine And Pharmacology, Pharmacy Keywords: Methicillin-resistant Staphylococcus aureus; biofilm; Antimicrobial agent; eugenol; Raman spectroscopy.

Online: 22 June 2023 (12:40:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0461.v1

Evaluation of Antibiotic Prescribing Pattern Using WHO Access, Watch and Reserve Classification in Kinshasa, Democratic Republic of Congo

Jocelyn Mankulu Kakumba, Jeremie Mbinze Kindenge, Paulin Mutwale Kapepula, Jean Marie Liesse Iyamba, Murielle Longokolo Mashi, Jose Wambale Mulwahali, Didi Mana Kialengila

Subject: Medicine And Pharmacology, Pharmacy Keywords: antibiotic; prescribing pattern; prescription; antimicrobial resistance; WHO AWaRe classification ;

Online: 18 April 2023 (02:54:31 CEST)

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Background: The AWaRe tool was set up by the World Health Organization (WHO) to promote the rational use of antimicrobials. Indeed, this tool classifies antibiotics into four groups, Access, Watch, Reserve and not-recommended antibiotics. In Republic Democratic of Congo, data on antibiotic dispensing (prescribing) by health professionals according to the AWaRe classification are scarce. In this research work, we aimed to explore antibiotic dispensing pattern from health professionals according to the WHO AWaRe classification to strengthen the national antimicrobial resistance plan. Methods: For this purpose, a survey was conducted from July to December 2022 in the district of Tshangu in Kinshasa. From randomly selected drugstores, drug-sellers were interviewed and randomly selected customers attending those drugstores were included in the study for medical prescriptions collection. The prescribed antibiotics were classified into the Access, Watch, Reserve and not recommended antibiotics group and by antibiotics number by prescription among pharmacies surveyed. Results: Of 400 medical prescriptions collected, 301 (75.25%) contained antibiotics. Of 301 prescriptions containing antibiotics, 164 (164/301; 54.5%) contained one antibiotic, 117 (117/301; 38.9%) two antibiotics, 15 (15/301; 5%) three antibiotics and 5 (5/301; 1.6%) 4 antibiotics. Out of the total of 463 antibiotics prescribed, 169 (169/463; 36.5%) were from the Access group, 200 (200/463; 43.2%) from the Watch group and 94 (94/463; 20.3%) from not recommended antibiotics group, respectively. Based on the anatomical, therapeutic and chemical (ATC) classification, it can be seen that third generation cephalosporins contained 34.33% of the prescribed antibiotics, followed by penicillins 17.17%, macrolides 7.63%, aminoglycosides 7. 36% and Imidazoles 7.36%, thus accounting approximately for 74% of the classes of antibiotics prescribed. Of the 463 antibiotics prescribed, the most frequently prescribed antibiotics were Ceftriaxone (21.38%), Amoxicillin (11.01%), Gentamycin (5.61%), Amoxicillin-clavulanic acid (5 .61%), Azithromycin (4.97%) and Metronidazole (4.75%), thus accounting for approximately 54% of all antibiotics prescribed. Conclusion: These results highlight the importance of strict implementation of the national plan to combat antimicrobial resistance and the need to train health workers in the correct application of the WHO AWaRe classification.

Preprint ARTICLE | doi:10.20944/preprints202305.1411.v1

Combination of Chemically Characterized Pomegranate Extract and Hydrophilic Vitamins against Prolonged Fatigue: A Monocentric, Randomized, Double-blind, Placebo-controlled Clinical Trial

Hammad Ullah, Eduardo Sommella, Alessandro Di Minno, Roberto Piccinocchi, Daniele Giuseppe Buccato, Lorenza Francesca De Lellis, Costanza Riccioni, Alessandra Baldi, Hesham R. El-Seedi, Shaden A. M. Khalifa, Gaetano Piccinocchi, Pietro Campiglia, Roberto Sacchi, Maria Daglia

Subject: Medicine And Pharmacology, Pharmacy Keywords: Prolonged fatigue; pomegranate extract; polyphenols; vitamin B complex; vitamin C

Online: 19 May 2023 (08:34:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202310.1375.v1

Gentiopicroside—The Biologically Active Plant Metabolite—An Insight into Its Pharmacological Significance and Future Perspectives

Lemonia Antoniadi, Magdalena Bartnik, Apostolis Angelis, Anna Wawruszak, Maria Halabalaki, Wirginia Kukula-Koch, Alexios-Leandros Skaltsounis

Subject: Medicine And Pharmacology, Pharmacy Keywords: gentiopicroside; Gentianaceae; in vitro and in vivo pharmacological activity; molecular mechanism of bioactivity; health benefits; semisynthetic derivatives of gentiopicroside

Online: 23 October 2023 (10:32:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1675.v1

Development of an Antiviral Ion-Activated In Situ Gel Containing 18β-Glycyrrhetinic Acid: A Promising Alternative Against Respiratory Syncytial Virus

Burcu Özkan, Ebru Altuntaş, Ümmühan Ünlü, Hasan Hüseyin Doğan, Yıldız Özsoy, Rabia Çakır Koç

Subject: Medicine And Pharmacology, Pharmacy Keywords: in situ gel; intranasal delivery, gellan gum; mucoadhesion; 18β-glycyrrhetinic acid; respiratory syncytial virus; common cold; antiviral activity

Online: 24 May 2023 (03:08:42 CEST)

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The human respiratory syncytial virus (hRSV) poses a serious risk to global public health and is a significant cause of severe lower respiratory infections. There are currently only a few therapies available to treat RSV infections, as well as no RSV vaccinations. Therefore, there is an urgent demand for clinically feasible, safe, and affordable RSV prevention and treatment alternatives. In this study, an ion-activated in situ gel comprising broad-spectrum antiviral 18β-glycyrrhetinic acid (GA) for antiviral action on RSV was developed. In this content, mechanical properties, sprayability, drug content, pH, ex vivo mucoadhesive strength, in vitro drug release pattern, and stability were all examined. Rheological properties were also tested by utilizing in vitro gelation capacity and rheological synergism tests. Finally, the optimized in situ gel's cytotoxic and antiviral activities on RSV cultured in human laryngeal epidermoid carcinoma (HEP-2) cell line were evaluated. In conclusion, the optimized in situ gel prepared with a combination of 0.5%w/w gellan gum and 0.5%w/w sodium carboxymethylcellulose demonstrated good gelation capacity and sprayability (weight deviation between T0 and T14: 0.34%), desired rheological synergism (mucoadhesive force (Fb): 9.53), mechanical characteristics (adhesiveness: 0.300 mJ ± 0.05), ex vivo bioadhesion force (19.67 g ± 1.90), drug content uniformity (RSD%: 0.494), and sustained drug release over period of 168 h (101.57% ± 0.53). The antiviral activity test results showed that the optimized in situ gel had strong anti-HRSV activity (EC50 simultaneous = 0.05 µg/ml, SI = 306; EC50 preinfection = 0.154 µg/ml, SI= 100) which was significantly higher than that of ribavirin (EC50 =4.189 µg/ml; SI= 28) used as a positive control against hRSV. In conclusion, this research has demonstrated the formulation of an effective antiviral nasal spray that has the ability to possess both prophylactic and virucidal activity.

Preprint ARTICLE | doi:10.20944/preprints202401.0343.v1

Spray-Drying Microencapsulation of Phenolic Compounds from Bauhinia ungulata L. Var. Obtusifolia Aqueous Extract: A Comparative Study Using Different Wall Materials

Myrth Soares do Nascimento Remigio, Teresa Greco, José-Otávio Carrera Silva-Júnior, Attilio Converti, Roseane Maria Ribeiro-Costa, Alessandra Rossi, Wagner Luiz Ramos Barbosa

Subject: Medicine And Pharmacology, Pharmacy Keywords: Phytotherapy; Medicinal plants; Radical scavenger; Phenolic compounds; Medicinal tea

Online: 4 January 2024 (11:27:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202403.0740.v1

Automated Non-Sterile Pharmacy Compounding: A Multi-Site Study in European Hospital and Community Pharmacies with Pediatric Immediate Release Propranolol Hydrochloride Tablets

Niklas Sandler, Farnaz Shokraneh, Mahsa Bahman, Julius Lahtinen, Niko Hassinen, Sari Airaksinen, Soumya Verma, Ludmila Hrizanovska, Jana Lass, Jyrki Heinämäki, Urve Paaver, Anssi Karlstedt, Janika Tähnas, Christoph Klaas, Catharina Kern, Adeline Bienfait, Frédéric Lagarce, Dominic Fenske, Katrin Muehlenfeld, Julia Malik, Holger Scherliess, Samuli Ojala, Sara P Cruz, Mattias Paulsson, Katja Kammonen, Maria Rautamo, Hendrik Lueck, Herwig Heindl, Laurent Carrez, Antoine Pierrot, Ralf Harnish, Stephanie Stareprawo, Marija Tubic-Grozdanii, Stefanie Zibolka, Uli Loesch, Martina Jeske, Ulrich Griesser, Karin Hummer, Andreas Thalmeier, Marianne Leitner, Susan Bischoff, Ralph Heimke-Brinck, Janine Paulus-Rohmer, Karim Khouckh, Fabien Bruno, Anna Harjans, Torsten Hoppe-Tichy

Subject: Medicine And Pharmacology, Pharmacy Keywords: automated compounding; hospital and community pharmcies; pharm inks; integrated quality control

Online: 13 March 2024 (12:02:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202310.1773.v1

Phytochemical and Biological Investigations of Ficus carica L. Leaf Extract Along with Formulation Development

Syed Zia ul Hasnain, Maryam Ahmed, Abdullah Y. Alzahrani, Mohsin Abbas Khan, M asif Wazir, Khizar Abbas

Subject: Medicine And Pharmacology, Pharmacy Keywords: Obesity; Diabetes; Ficus carica L.; Phytochemicals; Antioxidant

Online: 27 October 2023 (10:26:21 CEST)

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Utilization of medicine derived from plants has been documented in various traditional systems of medicines throughout the world for different diseases. Therefore, the current research work was carried out to evaluate the phytochemical and biological potential of Ficus carica L ethanolic leaf extract. For this purpose, physicochemical and phytochemical analysis, total phenolic and flavonoids contents was performed. Antioxidant potential was determined by FRAP, DPPH and H2O2 assay. Proteinase inhibition, heat induced hemolysis and BSA denaturation assay was carried out for inflammation. Antiglycation potential was assessed by fructosamine assay, Congo-red assay and estimation of free carbonyl groups. In-vivo antidiabetic, anti-obesity, effect on liver and kidney were investigated by high fat high sugar diet model. FTIR, HPLC and LCMS/MS analysis was performed to find out the compounds. Tablet based formulation was developed using wet granulation method and tested for physicochemical parameters. Results shows that total phenolic and flavonoids content was (333 mg GAE/g) and (123 mg RE/g) respectively, H2O2 assay shows 35.6% free radical inhibition potential, DPPH assay shows (IC50) inhibitory concentration at 0.58 mg/mL, and 88.769 µg/g Fe2SO4 solution FRAP values. Proteinase inhibition assay, Heat induced hemolysis and BSA-denaturation assay shows percentage inhibition of 28 ± 0.01, 55 ± 0.03 and 51.2 ± 0.05 respectively. In Antiglycation activity β-amyloid formation assay shows absorption of 0.017, Fructosamine assay shows inhibition of 19.4±0.06 and free carbonyl group estimation shows inhibition of 17.0±0.03. In in-vivo study FLE at (500 mg/kg) significantly decreased total bilirubin (p ≤ 0.001), decreased (p ≤ 0.05) alanine transferase, aspartate aminotransferase, alkaline phosphatase, decreased blood glucose, triglycerides and total cholesterol (p ≤ 0.01) while HDL (p ≤ 0.01) was significantly increased in comparison to obesity and diabetic-obesity groups. Different functional groups presence was confirmed by FTIR spectrum. HPLC analysis revealed the existence of ferulic acid, rutin, chlorogenic acid, coumarin and thymoquinone and these results are corelated by LC-MS/MS. Pre-compression characterization showed angle of repose (33.04°), bulk density (0.54 g/cm3), tapped density (0.73 g/cm3), compressibility index (35.179 %) and Hausner’s ratio (1.35), while the post-compression characterization showed weight variation 826±4.17 mg, thickness 10.50±0.25 kg/cm2, friability 0.57 %, and disintegration time 8.19 min. From the above results it is concluded that F. carica L. leaves extract has strong antioxidant, antidiabetic and hypolipidemic potential and can be used for an obesity and diabetes treatment.

Preprint REVIEW | doi:10.20944/preprints202310.0491.v2

Advancements in Sustained-Release Drug Delivery Systems

Sharul islam Barbhuiya, KM Shabana, Vishal Kumar

Subject: Medicine And Pharmacology, Pharmacy Keywords: sustain release; nanoparticles; microspheres; control release

Online: 25 October 2023 (14:10:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202309.0889.v1

Evaluation of Drug-Induced Dysphagia Profile Using a Japanese Real-World Database: A Pharmacovigilance Study

Eiji Kose, Mizuki Kawashima, Nobuhiro Yasuno

Subject: Medicine And Pharmacology, Pharmacy Keywords: adverse drug events; drug-induced dysphagia; Japanese adverse drug event report; reported odds ratios

Online: 14 September 2023 (04:33:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202311.0692.v1

Enhancing Tablet Dissolution Insights: A Comparative Study of Predictive ANN, PLS, and SVM Model With NIR Spectra

Shruti Ringe, Shounak Kulkarni, Abhijeet Sutar, Suresh Kumar BV, Anurag Shenoy

Subject: Medicine And Pharmacology, Pharmacy Keywords: chemometrics model; PAT; NIR; DoE; dissolution analysis; ANN; PLS; SVM

Online: 10 November 2023 (10:20:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202401.0803.v1

Flavonoids As CYP3A4 Inhibitors In Vitro

Martin Kondža, Ivica Brizić, Stela Jokić

Subject: Medicine And Pharmacology, Pharmacy Keywords: CYP enzymes; CYP3A4; flavonoid; inhibition; natural products

Online: 10 January 2024 (10:24:39 CET)

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Medicine and Pharmacology