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Preprint ARTICLE | doi:10.20944/preprints202208.0237.v1

A Quantitative Framework for Evaluating the Societal Impact of Antimicrobial Use Reduction in Agriculture

Eve Tresco Emes

Subject: Life Sciences, Other Keywords: AMR; agriculture; One Health; health economics; policy; modelling

Online: 12 August 2022 (11:28:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0225.v1

Positive or U-Shaped Association of Elevated Hemoglobin Concentration Levels with Metabolic Syndrome and Metabolic Components: Findings from Taiwan Biobank and UK Biobank

Vanessa Joy Timoteo, Kuang-Mao Chiang, Wen-Harn Pan

Subject: Life Sciences, Other Keywords: hemoglobin; iron nutrition status; metabolic syndrome; metabolic disorders; observational study; Taiwanese Han Chinese; European White

Online: 12 August 2022 (04:03:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0185.v1

Talaromyces santanderensis: a New Cadmium-tolerant Fungus from Cacao Soils in Colombia

Beatriz E. Guerra Sierra, Luis A. Arteaga-Figueroa, Susana Sierra-Pelaéz, Javier C Alvarez

Subject: Life Sciences, Other Keywords: fungal systematics; Talaromyces santanderensis; cadmium; cacao rhizosphere; mycoremediation

Online: 10 August 2022 (03:29:20 CEST)

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Inorganic pollutants in Colombian cocoa (Theobroma cacao L.) agrosystems cause problems in the production, quality, and exportation of this raw material. There has been an increased interest in bioprospecting studies of different fungal species focused on the biosorption of heavy metals. Furthermore, fungi constitute a valuable, profitable, ecological, and efficient natural soil resource that could be considered in the integrated management of cadmium mitigation. In this study, we report a new species of Talaromyces, isolated from cocoa soil from San Vicente de Chucurí-Colombia. The characterization of the culture was performed on six different standardized media and was distinguished by characteristic colony morphology: biverticillate and monoverticillate penicilli, acerose phialides, and slightly globose smooth-walled conidia. Culture was featured by bright yellow mycelium in young culture on CYA and CYAS medium. Colonies grew faster on Malt and Oat agar, attaining 36 and 32 mm diameter after seven days at 20 ºC. High acid production on CREA medium at 20-30 ºC was observed. Phylogenetic analysis was based on the ITS region and the RPB2, Calmodulin (CaM) and β-Tubulin genes that indicate that it is new to science and is named Talaromyces santanderensis sp. nov. This new species belongs to the Talaromyces section and is closely related to T. lentulus and related to T. soli, T. tumuli and T. pratensis (inside the T. pinophilus species complex) in the inferred phylogeny. Mycelia growth of the fungal strains was subjected to a range of 0-400 ppm Cd and incorporated into malt extract agar (MEA) in triplicates. Fungal radial growth was recorded every three days over a 13-days incubation period and In vitro cadmium tolerance tests showed a high tolerance index = 0,81 when the mycelium was exposed to 300 ppm of Cd. Results suggest T. santanderensis showed tolerance to Cd concentrations that exceed the permissible limits for contaminated soils, and it is promising for its use in bioremediation strategies to eliminate Cd from highly contaminated agricultural soils.

Preprint ARTICLE | doi:10.20944/preprints202208.0181.v1

Blood Leukocyte Transcriptional Modules and Differentially Expressed Genes Associated with Disease Severity and Age in COVID-19 Patients

Silvia Yumi Bando, Fernanda Bernardi Bertonha, Sandra E Vieira, Danielle B. L. Oliveira, Vanessa N Chalup, Edison L Durigon, Patricia Palmeira, Ana Cristina P Curi, Caroline S Faria, Leila Antonangelo, Gerhard da P Lauterbach, Fabiane A Regalio, Roberto M Cesar Jr, Carlos Alberto Moreira-Filho

Subject: Life Sciences, Other Keywords: COVID-19; SARS-CoV-2; disease severity; blood leukocyte transcriptome; WGCNA; transcriptional modules; differentially expressed genes; COVID-19 transcriptional markers

Online: 9 August 2022 (14:59:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0179.v1

Measurement Uncertainty Interval In Case of a Known Relationship between Precision and Mean

Steffen Uhlig, Bertrand Colson, Petra Gowik

Subject: Life Sciences, Other Keywords: In-house validation study; reproducibility precision; measurement uncertainty; prediction interval; uncertainty interval

Online: 9 August 2022 (10:56:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0169.v1

Impact of Socio-economic Deprivation on the Local Spread of COVID-19 Cases Mediated by the Effect of Seasons and Restrictive Public Health Measures: A Retrospective Observational Study

Nicola Bartolomeo, Massimo Giotta, Silvio Tafuri, Paolo Trerotoli

Subject: Life Sciences, Other Keywords: COVID-19; social inequalities; deprivation index; incidence rate; restrictive public health measures; local spread; GEE model

Online: 9 August 2022 (04:02:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0125.v1

Pomegranate Biowastes Are Rich in Valuable Bioactive-Compounds With Potential Benefit on Human Health

Federica Marra, Beatrix Petrovicova, Francesco Canino, Angela Maffia, Carmelo Mallamaci, Adele Muscolo

Subject: Life Sciences, Other Keywords: antioxidants; bioactive compounds; nutraceuticals; phenols; pomegranate peels

Online: 5 August 2022 (14:38:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0101.v1

Greek Military Nursing Officers’ Leadership Style: Compassion Competence and Personal Level at Work

KLIMENTIDOU THOMAI, Pavlos Sarafis, IOANNIS APOSTOLAKIS, MARIA MALLIAROU

Subject: Life Sciences, Other Keywords: compassion; military nurse; leadership style

Online: 4 August 2022 (05:21:03 CEST)

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Abstract: The present study seeks to investigate MNOs leadership style and how it influences their compassion competence and their personal level of compassion at work. This is a cross-sectional study carried out from December 2019 to May 2020 using the method of convenience sampling. The study involved 235 MNOs serving in Greek Military Hospitals. A single questionnaire containing Compassion at Work index, Compassion competence scale, and Multifactor Leadership Questionnaire (MLQ-5X), and socio-demographic and professional data, was used for data collection. A total of 400 printed questionnaires were distributed with a response rate of 58.75%. Data analysis was performed using the statistical package SPSS 22.0. The research showed that the transformational and transactional leadership styles coexist in the Nursing Corps of the Armed Forces with an average value of 2.72(SD=0.70)-2.95(SD=0.54) points and 2.47(SD=0.69)-2.74(SD=0.63) points respectively, while the passive style represented a very small percentage with an average subscale value of 0.88(SD=0.61)-0.94(SD=0.63) points. It was also found that both actual compassion at work and compassion ability had improved with the increase of transformational or transactional leadership style characteristics and amelioration of leadership outcome criteria. On the other side, a deterioration of these was observed with the increase of the passive leadership. Specifically, a higher score in the «Intellectual Stimulation» scale was associated with a higher level of compassion at work in the dimension «Experiencing the suffering of others» (p=0.010/SD=0.14), while higher values on the «Laissez-Faire Leadership» scale were associated with less compassion at work in the same dimension (p<0.001/SD=0.13). Also, a higher score on the «Contingent Reward» scale was associated with more compassion at work in the dimension «Takes appropriate action» (p=0.023/SD=0.16). Furthermore, higher values observed in the «Inspirational Motivation», «Individual Consideration» and «Extra Effort» scales were associated with a better communication ability (p=0.035/SD=0.09, p=0.022/SD=0.12, and p=0.042/SD=0.08 accordingly). Finally, a higher score on the «Effectiveness» scale was associated with higher sensitivity (p=0.049/SD=0.08). Teaching appropriate leadership behavior, promoting a culture of compassion, and continuing to train nurses to manage their emotions should be included in the infrastructure of nursing science.

Preprint REVIEW | doi:10.20944/preprints202208.0041.v1

Mammary Gland Infection and Its Association with Other Periparturient Diseases of Dairy Cows

Ashley Egyedy, Burim N. Ametaj

Subject: Life Sciences, Other Keywords: dairy cow; mammary gland; mastitis; periparturient diseases

Online: 2 August 2022 (05:58:45 CEST)

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Preprint ESSAY | doi:10.20944/preprints202208.0037.v1

“Deep Sleep”: A Comparative Approach to Defining Meaningful Rest

Matt Gaidica

Subject: Life Sciences, Other Keywords: deep sleep; slow-wave activity; evolution; comparative; physiology; homeostasis

Online: 2 August 2022 (04:46:33 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202208.0025.v1

Next-Generation Sequencing Comparative Analysis of DNA Mutations between Blood-derived Extracellular Vesicles and Matched Cancer Tissue in Patients with IV Grade Glioblastoma

Paolo Rosa, Elena De Falco, Luca Pacini, Amedeo Piazza, Paolo Ciracì, Luca Ricciardi, Francesco Fiorentino, Sokol Trungu, Massimo Miscusi, Antonino Raco, Antonella Calogero

Subject: Life Sciences, Other Keywords: glioblastoma; extracellular vesicles; Next Generation Sequencing; pathogenic mutations; NF1

Online: 1 August 2022 (15:07:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0463.v1

Predictive Values of Nocturia and Its Voiding Frequency on the Aging Males’ Symptoms

John Wai-Man Yuen, Ivy Yuen-Ping Wong, Peter Ka-Fung Chiu, Jeremy Yuen-Chun Teoh, Chi-Kwok Chan, Chi-Hang Yee, Chi-Fai Ng

Subject: Life Sciences, Other Keywords: Nocturia; aging male symptoms; Quality of life; Health-related Quality of life; Male adults; NQoL; Urinary frequency; Bedtime urination; sleep

Online: 29 July 2022 (13:13:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0453.v1

Applications of the Novel Quantitative Pharmacophore Activity Relationship Method QPhAR in Virtual Screening and Lead-optimization

Stefan Michael Kohlbacher, Matthias Schmid, Thomas Seidel, Thierry Langer

Subject: Life Sciences, Other Keywords: pharmacophore; pharmacophore modelling; quantitative pharmacophore; QSAR; machine learning; pharmacophore optimization; NeuroDeRisk

Online: 29 July 2022 (08:47:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0366.v1

Community Knowledge, Attitudes and Practices Regarding Onchocerciasis in Rural Villages With a High Epilepsy Prevalence in Mahenge, Tanzania: A Qualitative Study

Dan K. Bhwana, Isolde S. Massawe, Adiel K. Mushi, Pendo Mashili, Luis-Jorge Amaral, Williams Makunde, Bruno P. Mmbando, Robert Colebunders

Subject: Life Sciences, Other Keywords: onchocerciasis; community directed treatment with ivermectin; elimination; epilepsy; focus group discussions; misconceptions

Online: 25 July 2022 (09:27:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0351.v1

Almamy Amara Touré, Aboubacar Sidiki Magassouba, Gnoume Camara, Abdoulaye Doumbouya, Diao Cissé, Ibrahima Barry, Lansana Mady Camara, Abdoul Habib Béavogui, Alexandre Delamou, Vanessa Veronese, Corinne Simone Merle, Hugues Asken Traoré, Adama Marie Bangoura

Subject: Life Sciences, Other Keywords: Tuberculosis; Health-related quality of life; COVID-19; Guinea

Online: 25 July 2022 (05:37:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0348.v1

Identification of Changes In Rumination Behavior Registered With An Online Sensor System In Cows With Subclinical Mastitis

Ramūnas Antanaitis, Vida Juozaitienė, Dovilė Malašauskienė, Mindaugas Televičius, Mingaudas Urbutis, Arūnas Rutkauskas, Greta Šertvytytė, Walter Baumgartner

Subject: Life Sciences, Other Keywords: subclinical mastitis; rumination; activity; early diagnosis; precision agriculture

Online: 25 July 2022 (05:23:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0260.v1

Evaluating the Sensitivity of Heat Wave Definitions Among North Carolina Physiographic Regions

Jagadeesh Puvvula, Azar Abadi, Kathryn Conlon, Jared Rennie, Hunter Jones, Jesse Bell

Subject: Life Sciences, Other Keywords: Heat Wave; Heat-related illness; Early heat-health warning systems

Online: 18 July 2022 (10:14:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0224.v1

Recognizing and Distinguising the Phenomenon Referred to as Meningioma

Bruce M. Rothschild

Subject: Life Sciences, Other Keywords: meningioma; hemangioma; cranial pathology; porotic hyperostosis; differential diagnosis; osteosarcoma

Online: 14 July 2022 (12:29:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0212.v1

Main Agro-ecological Structure, MAS: An Index for Evaluating Agro-biodiversity in Agro-ecosystems

Ingrid Quintero, Yesica Xiomara Daza-Cruz, Tomás Enrique León-Sicard

Subject: Life Sciences, Other Keywords: Main Agroecological Structure; agroecology; Andean agroecosystems; agrobiodiversity index; cultural dimensions; farmer awareness

Online: 14 July 2022 (11:28:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0198.v1

Association of Serum and Urinary Magnesium Levels With Body Composition and Inflammatory Markers in Patients With Non-dialysis Chronic Kidney Disease: A Longitudinal Approach

Raimunda Sheyla Carneiro Dias, Dyego José de Araújo Brito, Cleodice Alves Martins, Elton Jonh Freitas Santos, Erika Cristina Ribeiro de Lima Carneiro, Elisangela Milhomen dos Santos, Denizar Vianna Araújo, Natalino Salgado Filho, Mario Bernardo Filho

Subject: Life Sciences, Other Keywords: Magnesium deficiency; Body composition; Chronic kidney failure.

Online: 13 July 2022 (09:27:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0118.v1

Potential Properties of Natural Nutraceuticals and Antioxidants in Eye Protection

Jessica Maiuolo, Rosamaria Bulotta, Francesca Oppedisano, Vincenzo Musolino, Micaela Gliozzi, Cristina Carresi, Federica Scarano, Saverio Nucera, Miriam Scicchitano, Martina Nicita, Rosamaria Caminiti, Francesca Bosco, Roberta Macrì, Adriano Carnevali, Vincenzo Scorcia, Vincenzo Mollace

Subject: Life Sciences, Other Keywords: Eyes diseases; Oxidative damage; Antioxidant compounds; Vitamin A; Vitamin C; Lutein; Curcumin; Quercetin; Coenzyme Q10; PUFAs; BPF; Grape seed

Online: 7 July 2022 (09:04:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0408.v1

A Machine Learning Method to Assess Growth Patterns in Plants of the Family Lemnaceae

Leone Ermes Romano, Maurizio Iovane, Luigi Gennaro Izzo, Giovanna Aronne

Subject: Life Sciences, Other Keywords: Duckweed; Machine learning; Image analysis; Machine training; Aquatic plants; Lemnaceae; Lemna

Online: 29 June 2022 (14:56:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0373.v1

Hoof Impact and Foot-off Accelerations in Galloping Thoroughbred Racehorses Trialling Eight Shoe-Surface Combinations

Kate Horan, James Coburn, Kieran Kourdache, Peter Day, Henry Carnall, Liam Brinkley, Dan Harborne, Lucy Hammond, Mick Peterson, Thilo Pfau, Sean Millard

Subject: Life Sciences, Other Keywords: racehorse; hoof; acceleration; gallop; shoeing; surface; stride time

Online: 28 June 2022 (04:20:25 CEST)

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The athletic performance and safety of racehorses is influenced by hoof-surface interactions. This intervention study assessed the effect of eight horseshoe-surface combinations on hoof acceleration patterns at impact and foot-off in 14 galloping Thoroughbred racehorses retired from racing. Aluminium, barefoot, GluShu (aluminium-rubber composite) and steel shoeing conditions were trialled on turf and artificial (Martin Collins Activ-Track) surfaces. Shod conditions were applied across all four hooves. Tri-axial accelerometers (SlamStickX, range ±500 g, sampling rate 5000 Hz) were attached to the dorsal hoof wall (x: medio-lateral, medial=positive; y: along dorsal hoof wall, proximal=positive; z: perpendicular to hoof wall, dorsal=positive). Linear mixed models assessed whether surface, shoeing condition or stride time influenced maximum (most positive) or minimum (most negative) accelerations in x, y and z directions, using ≥40,691 strides (significance at p<0.05). Day and horse-rider pair were included as random factors and stride time as a covariate. Collective mean accelerations across x, y and z axes were 22–98 g at impact and 17–89 g at foot-off. Mean stride time was 0.48 ± 0.07 s (mean ± 2 s.d.). Impact accelerations were larger on turf in all directions for forelimbs and hindlimbs (p≤0.015), with the exception of forelimb z-minimum, and in absolute terms maximum values were typically double minimum values. Surface-type affected all foot-off accelerations (p≤0.022), with the exception of hindlimb x-maximum; for example, there was an average increase of 17% in z-maximum across limbs on the artificial track. Shoe-type influenced all impact and foot-off accelerations in forelimb and hindlimb datasets (p≤0.024), with the exception of hindlimb impact y-maximum. Barefoot hooves generally experienced the lowest accelerations. Stride time affected all impact and foot-off accelerations (p<0.001). Identifying factors influencing hoof vibrations on landing and hoof motion during propulsion bears implication for injury risk and racing outcomes.

Preprint REVIEW | doi:10.20944/preprints202206.0370.v1

How Did Life Emerge in Chemically Complex Messy Environments?

Kenji Ikehara

Subject: Life Sciences, Other Keywords: GADV hypothesis; origin of life; protein 0th-order structure; origin of protein; [GADV]-microsphere; origin of gene: the core life system

Online: 28 June 2022 (03:41:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0355.v1

Metabolic Pathways of Leishmania Parasite: Source of Pertinent Drug Targets and Potent Drug Candidates

Surbhi Jain, Utkarsha Sahu, Awanish Kumar, Prashant Khare

Subject: Life Sciences, Other Keywords: Leishmania; Human Pathogen; Targeting Metabolic Pathways; Repurposed Drugs; New Antileishmanials.

Online: 27 June 2022 (08:47:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0343.v1

A Systematic Review of the Effect of Stress in Animals During Adolescence, and Its Long-Term Consequences during Adulthood: Focus on Hippocampal Neurogenesis, Cognitive Function and Behavioural Outcomes

Alessandra Borsini, Juliette Giacobbe, Gargi Mandal, Maura Boldrini

Subject: Life Sciences, Other Keywords: animal models; adolescence; hippocampal neurogenesis

Online: 27 June 2022 (03:18:28 CEST)

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Adolescence represents a critical period for the programming of future adult behaviours. Neurogenesis is particularly active during adolescence, with increased number of granule cells and increased hippocampal volume both in animals and humans. Among the factors which can affect neurogenesis during adolescence, stress is considered a major one. Indeed, adolescence is known to be a particularly stressful period in life, with some adolescents suffering from mood disorders and anxiety. While there is increasing interest on the neurogenic changes occurring during the adolescent period, evidence is sparse. We conducted a systematic review summarising changes in hippocampal neurogenesis, neuroplasticity and hippocampal-dependent cognitive functions and behavioural outcomes in stress-induced adolescent animal models of depression, and investigating long-term stress effects on the same outcomes assessing the same animals in adulthood. Overall, the results show a significant reduction in hippocampal cell proliferation, and a concomitant increase in depressive-like behaviours in adolescent animals exposed to stress challenges, however reduction in the number of surviving neurons was accompanied by no changes in both cognition and behaviour. Studies also observed altered neuroplasticity, including a stress-induced decrease in markers of pre- and post-synaptic plasticity, dendritic spine length and density, and long-term potentiation. These changes in neuroplasticity were accompanied by cognitive impairments and depressive-like behaviours. Overall, some of the negative effects observed during adolescence, especially on cell proliferation, neuroplasticity, cognition and behaviour either persisted or worsened during adulthood. Interestingly, treatment during adolescence with antidepressants, glutamate receptor inhibitors, glucocorticoid antagonists, or a healthy diet consisting of omega-3 fatty acids and vitamin A, were able to reverse or prevent these detrimental effects. Future research should aim to investigate the translational impact of these preclinical findings, developing novel tools for the measurement of hippocampal neurogenesis directly in depressed adolescents, and subsequently assessing neurogenic changes in response to stress as well as pharmacological and non-pharmacological interventions.

Preprint ARTICLE | doi:10.20944/preprints202206.0337.v1

Accuracy Testing of ETo Calculator (Ukraine) App: A Comparison Between Penman-Monteith and Temperature-Based Reference Evapotranspiration Assessment Methods

Pavlo Lykhovyd

Subject: Life Sciences, Other Keywords: agrometeorology; irrigation; information technology; statistics; water management

Online: 24 June 2022 (09:53:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0320.v1

Ten Simple Rules for Using Public Data for Your Research

Vishal Oza, Jordan Whitlock, Elizabeth Wilk, Angelina Uno-Antonison, Brandon Wilk, Manavalan Gajapathy, Timothy Howton, Austyn Trull, Lara Ianov, Elizabeth Worthey, Brittany Lasseigne

Subject: Life Sciences, Other Keywords: data; reproducibility; FAIR; data reuse; public data; big data; analysis

Online: 23 June 2022 (08:06:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0317.v1

Chickpea Water and Chickpea Polyphenols Induce Apoptosis and Alleviate Cell Migration In Vitro in Human Colon Adenocarcinoma Cells

Heidi Bochenek, Nidhish Francis, Abishek B. Santhakumar, Christopher L. Blanchard, Kenneth A. Chinkwo

Subject: Life Sciences, Other Keywords: chick pea; chick pea water; apoptosis; cytotoxicity; colorectal cancer; polyphenols

Online: 22 June 2022 (11:50:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0243.v1

High Pyrethroid Resistance to Deltamethrin and DDT in Major Malaria Vector Anopheles gambiae s.l. from South-Western Nigeria is Probably Driven by Metabolic Resistance Mechanisms

Adedapo O. Adeogun, Ahmed Omotayo, Ayodele Babalola, Tosin Joseph, Oluwakemi Adesalu, Romoke Jimoh, Tolulope Oyeniyi, Samson Awolola, Olusola Ladokun

Subject: Life Sciences, Other Keywords: Insecticide resistance; Anopheles gambiae; Anopheles coluzzii; Cytochrome P450; Gluthathi-one-S-Transferases

Online: 17 June 2022 (03:31:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0197.v1

Salt Stress Affects the Photosynthetic and Chlorophyll Fluorescence Responses in Lettuce (Lactuca sativa L.)

Bikash Adhikari, Omolayo J. Olorunwa, T. Casey Barickman

Subject: Life Sciences, Other Keywords: sodium chloride; photosystem II; Green Forest; carbon assimilation; salt-sensitive; C3 plant; climate change; abiotic stress

Online: 14 June 2022 (08:04:31 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0119.v1

Health System and Policy Analysis: Why There Is a Need for a Paradigm Shift in Our Approach to Improve Health Status of Brick-Kiln Migrant Workers in India?

Fnu Kajal

Subject: Life Sciences, Other Keywords: health policy; unorganised sector; brick-kiln workers; migrant; migration

Online: 8 June 2022 (08:54:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0114.v1

Metabolic Food Waste as Food Insecurity Factor – Causes and Preventions

Ioana Mihaela Balan, Emanuela Diana Gherman, Ioan Brad, Remus Gherman, Adina Horablaga, Teodor Ioan Trasca

Subject: Life Sciences, Other Keywords: food security; sustainable and healthy food choices/systems; metabolic food waste; nutrition; overconsumption

Online: 8 June 2022 (05:21:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0110.v1

Sustainable Consumption Pattern for Increased Food Security – Case Study Romania

Ioana Mihaela Balan, Emanuela Diana Gherman, Remus Gherman, Ioan Brad, Raul Pascalau, Gabriela Popescu, Teodor Ioan Trasca

Subject: Life Sciences, Other Keywords: food security; food waste; nutrition; overconsumption; sustainable and healthy food choices/systems

Online: 8 June 2022 (03:35:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0056.v1

The Current Status of Cigarette Smoking and Air Pollution Associated Lung Cancer

Fayang Ma

Subject: Life Sciences, Other Keywords: lung cancer; cigarette smoking; air pollution; epidemiology; etiology

Online: 6 June 2022 (03:51:38 CEST)

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Preprint SHORT NOTE | doi:10.20944/preprints202206.0032.v1

Application of the Bayesian Conformity Assessment Framework from JCGM 106:2012 for Lot Inspection on the Basis of Single Items

Bertrand Colson, Steffen Uhlig, Rainer Göb, Petra Gowik

Subject: Life Sciences, Other Keywords: Conformity assessment; lot inspection; acceptance sampling; Quality level; sample size; Bayesian statistics; prior distribution; posterior distribution; consumer risk; producer risk

Online: 2 June 2022 (10:59:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0014.v1

Microbial Degradation of Pharmaceuticals

Swathi Kandhasamy, Sudha Balraj, Suganya Kanagaraj, Sumathi Sundaravadivelu

Subject: Life Sciences, Other Keywords: pharmaceutical toxicants; recalcitrant pollutants; co-metabolic pathways; biostimulation; bioaug-mentation

Online: 1 June 2022 (10:29:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0394.v1

Growth Performance, Carcass Characteristics and Economic Viability of Nguni Cattle Fed Diets Containing Graded Levels of Opuntia ficus-indica

Ayanda Nyambali, Mthunzi Mndela, Julius Tlou Tjelele, Cletos Mapiye, Phillip Strydom, Emiliano Raffrenato, Kennedy Dzama, Vorster Muchenje, Ntuthuko Raphael Mkhize

Subject: Life Sciences, Other Keywords: animal growth performance; carcass traits; economic returns; Nguni cattle heifers; spineless cactus diets

Online: 30 May 2022 (11:17:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0290.v1

PCSK9 Inhibitors: Pharmacology and Therapeutic Potential

Kuldeep Singh, Jeetendra Kumar Gupta, Shivendra Kumar, Krishanveer Singh, Km Meenakshi, Karan Kumar

Subject: Life Sciences, Other Keywords: Cholesterol; PCSK9 inhibitors; HMG-CoA; LDL receptor; statins

Online: 23 May 2022 (10:01:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0197.v1

Evaluation of Biological Activity of Natural Compounds: Current Trends and Methods

Carlos Barba-Ostria, Saskya E. Carrera-Pacheco, Rebeca Gonzalez-Pastor, Jorge Heredia-Moya, Arianna Mayorga-Ramos, Cristina Rodríguez-Pólit, Johana Zúñiga, Benjamin Arias-Almeida, Linda P. Guamán

Subject: Life Sciences, Other Keywords: Natural product; bioactive compounds; antimicrobial; antioxidant

Online: 16 May 2022 (05:07:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0116.v1

A Novel Neurofilament Light Chain ELISA Validated in Patients with Alzheimer’s Disease, Frontotemporal Dementia, Subjective Cognitive Decline, and the Evaluation of Candidate Proteins for Immunoassay Calibration

Shreyasee Das, Nele Dewit, Dirk Jacobs, Yolande A.L. Pijnenburg, Sjors G.J.G. In 't Veld, Salomé Coppens, Milena Quaglia, Christophe Hirtz, Charlotte E Teunissen, Eugeen J.M. Vanmechelen

Subject: Life Sciences, Other Keywords: Neurofilament-light; biomarker; immunoassay; ELISA; calibrator

Online: 9 May 2022 (10:14:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0092.v1

Fluctuation of Serum CEA in the Conventional Normal Range and The Risk of Relapse Following Curative Intent Treatment of Colorectal Cancer

Zsolt Fekete, Patricia Suteu, Laura Gligor, Nicolae Todor, Alina-Simona Muntean, Alexandra Gherman, Dan Eniu

Subject: Life Sciences, Other Keywords: CEA 1; colorectal cancer 2; follow-up 3; tumor markers 4; early intervention 5; adjuvant chemotherapy 6

Online: 7 May 2022 (04:09:32 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202205.0060.v1

Postacute Laryngeal Injuries and Dysfunctions in COVID-19 Patients: A Scoping Review

Jerome R Lechien, Stephane Hans

Subject: Life Sciences, Other Keywords: COVID-19; otolaryngology; Larynx; laryngeal; laryngology; intubation; voice; Head Neck; surgery

Online: 6 May 2022 (04:37:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0189.v1

TGF-β as a Key Modulator of Astrocyte Reactivity

Jian Luo

Subject: Life Sciences, Other Keywords: astrocytes; reactive astrogliosis; TGF-β; traumatic brain injury; stroke; aging; Alzheimer’s disease; Parkinson’s disease; amyotrophic lateral sclerosis; multiple sclerosis; epilepsy

Online: 20 April 2022 (09:06:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0149.v1

Visiting Sweet Potato from a Breeding Perspective: An Update

Shankar AB, Prashant Kaushik

Subject: Life Sciences, Other Keywords: sweet potato; breeding; genetics; genomics; health

Online: 15 April 2022 (14:58:08 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202204.0104.v1

Statistical Modelling and Experimental Design for the Validation of Droplet Digital PCR Methods

Steffen Uhlig, Christopher Weidner, Bertrand Colson

Subject: Life Sciences, Other Keywords: Method validation; droplet digital PCR; orthogonal factorial design; variance components; Poisson assumption; cloglog model; target DNA copies per droplet; Monte Carlo; prediction interval

Online: 12 April 2022 (08:46:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0083.v1

Impact of the Filling Medium on the Colour and Sensory Characteristics of Canned European Eels (Anguilla anguilla L.)

Sidonia Martínez, Javier Carballo, Miriam Rodríguez-González, Lucía Gómez-Limia

Subject: Life Sciences, Other Keywords: olive oil; sunflower oil; spicy olive oil; canned eel; colour; sensory analysis

Online: 9 April 2022 (01:36:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0053.v1

Computational Investigations on the Natural Small-Molecule as an Inhibitor of Programmed Death Ligand-1 for Cancer Immunotherapy

Geethu S. Kumar, Mahmoud Moustafa, Amaresh Kumar Sahoo, Petr Malý, Shiv Bharadwaj

Subject: Life Sciences, Other Keywords: Programmed death ligand-1; Natural products; Immunotherapy; Neoenactin B1; Molecular dynamics simulation

Online: 7 April 2022 (04:08:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0402.v1

Tuberculosis among Peoples Who Were Living on the Street and Used Alcohol, Tobacco, and Illegal Drugs: Analysis of Territories in Extreme Vulnerability and Trends in Southern Brazil

Alessandro Rolim Scholze, Josilene Dália Alves, Thaís Zamboni Berra, Antônio Carlos Vieira Ramos, Flávia Meneguetti Pieri, Sandra Cristina Pillon, Júlia Trevisan Martins, Maria José Quina Galdino, Emiliana Cristina Melo, Felipe Mendes Delpino, Inês Fronteira, Ricardo Alexandre Arcêncio

Subject: Life Sciences, Other Keywords: Tuberculosis; Vulnerable populations; Homeless Persons; Substance-Related Disorders

Online: 31 March 2022 (08:05:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202203.0299.v1

Assessing Carbon Pools of Three Indigenous Agroforestry Systems in the South-Eastern Rift- Valley Landscapes, Ethiopia

Hafte Mebrahten Tesfay, Mesele Negash, Douglas L. Godbold, Herbert Hager

Subject: Life Sciences, Other Keywords: Biomass; Carbon pool; Indigenous agroforestry system; Coffee; Enset; South-eastern Ethiopia

Online: 22 March 2022 (10:51:01 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0295.v1

Genetic Diversity of Schistosoma Haematobium in Sub-Saharan Africa: A Systematic Review

Rabecca Tembo, Panji Nkhoma, Mildred Zulu, Florence Mwaba, John Yabe, Hikabasa Halwiindi, Moses Kamwela, King S. Nalubamba, Chummy S. Sikasunge, Andrew M. Phiri

Subject: Life Sciences, Other Keywords: Urinary schistosomiasis; Schistosoma haematobium; sub-Saharan Africa; Genetic Diversity

Online: 22 March 2022 (04:25:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0130.v1

Vegetable Extracts for Adaptive Agriculture: A Preliminary Assessment in Italy

Rita Leogrande, Daniel El Chami, Giuseppe Piegari, Mario Elefante, Michele Di Carolo, Donato Perrelli, Giulio Fumarola, Crescenza Dongiovanni

Subject: Life Sciences, Other Keywords: vegetable extract; seaweed extract; agrosystems; resilience; Apulia (Italy)

Online: 9 March 2022 (09:53:25 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202109.0437.v2

The Glial Aging & Senescence Hypothesis of Late-onset Alzheimer’s

Victor Lau, Leanne Ramer, Marie-Ève Tremblay

Subject: Life Sciences, Other Keywords: Alzheimer's; Cellular senescence; Neurodegeneration; Microglia; Astrocytes; Oligodendrocyte Progenitor Cells; TREM2; Braak staging; Oxidative stress; Phapoptosis; Amyloid-beta; Tau; Neuritic plaques

Online: 7 March 2022 (14:22:25 CET)

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Alzheimer’s disease (AD) predominantly occurs as a late-onset form (LOAD), involving neurodegeneration and cognitive decline with progressive memory loss. Over time, risk factors and aging promote accumulation of well-known AD pathologies in oxidative stress, amyloid-beta and tau protein pathology, as well as inflammation. Homeostatic glial functions regulate and suppress these AD pathologies; however, other glial states involve increased pro-inflammatory cytokine release and further pathology accumulation. Different stresses can additionally induce cellular senescence, or an irreversible differentiation process resulting in decreased supportive functions and increased, pro-inflammatory cytokine release. While these pathophysiological underpinnings all contribute to LOAD, they require temporal and mechanistic integration. This perspective hypothesizes that when individuals have threshold senescent glia accumulation, they transition from healthy cognition into mild cognitive impairment and LOAD diagnosis. Particularly, senescent microglia are predicted to represent a final threshold required for the tau pathology burden and spreading that corresponds to sustained neurodegeneration and dementia severity. We first explore age-related decline in glia that promote increases in AD pathologies, and then discuss emerging evidence linking oxidative stress, neurons containing tau pathology, and amyloid-beta to microglia, oligodendrocyte progenitor cell, and astrocyte senescence. Our hypothesis proposes that senescent astrocytes and oligodendrocyte progenitors pressure microglia to phagocytose neurons containing tau pathology. The resulting senescent microglia would form neuritic plaques and induce paracrine senescence transitioning into a progressive clinical dementia presentation. This predictive hypothesis can potentially account for why medications used to treat LOAD fail, as previous treatments have not reduced senescent glial burden. It is also coherent with the predominant hypotheses surrounding LOAD, generates testable hypotheses about LOAD, and increases rationale in testing senolytics as targeted treatments for LOAD arrest and reversal.

Preprint CASE REPORT | doi:10.20944/preprints202203.0022.v1

Outpatient High-Dose-Rate Mold Brachytherapy for Lower Gingival Squamous Cell Carcinoma: A First Report

Ami Takeshita, Hiroaki Shimamoto, Yuka Uchimoto, Tomomi Tsujimoto, Tetsuo Miyamoto, Sven Kreiborg, Sanjay M Mallya, Michio Oda, Takero Hirata, Kazuhiko Ogawa, Hiroya Shiomi, Shumei Murakami

Subject: Life Sciences, Other Keywords: gingival cancer; mold brachytherapy; radiation therapy; outpatient

Online: 1 March 2022 (12:44:09 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202203.0013.v1

Radiation-Induced Undifferentiated Spindle Cell Sarcoma Following High-Dose-Rate Interstitial Brachytherapy for Tongue Squamous Cell Carcinoma

Yuka Uchimoto, Hiroaki Shimamoto, Ami Takeshita, Kaori Oya, Mitsunobu Kishino, Yasuo Fukuda, Satoru Toyosawa, MIchio Oda, Kazuhiko Ogawa, Sven Kreiborg, Sanjay M. Mallya, Shumei Murakami

Subject: Life Sciences, Other Keywords: radiation-induced; sarcoma; brachytherapy; tongue

Online: 1 March 2022 (09:53:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0350.v1

Bifidobacterium Species Colonization in Infancy: A Global Cross-Sectional Comparison by Population History of BreastFeeding

Diana H. Taft, Zachery T. Lewis, Nhu Nguyen, Steve Ho, Chad Masarweh, Vanessa Dunne-Castagna, Daniel J. Tancredi, M Nazmul Huda, Charles B. Stephensen, Katie Hinde, Erika von Mutius, Pirkka Kirjavainen, Jean-Charles Dalphin, Roger Lauener, Josef Riedler, Jennifer T. Smilowitz, J. Bruce German, Ardythe L. Morrow, David A. Mills

Subject: Life Sciences, Other Keywords: infant; breastfeeding; gut microbiome; Bifidobacterium

Online: 28 February 2022 (08:53:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0153.v2

Trends in Excess Winter Mortality (EWM) From 1900/01 to 2019/20—Evidence for a Complex System of Multiple Long-Term Trends

Rodney P. Jones, Andrey Ponomarenko

Subject: Life Sciences, Other Keywords: winter mortality; trends; season; estimated influenza mortality; pandemic influenza; aging

Online: 25 February 2022 (14:24:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0318.v1

Hypnotizability-Related Cerebral Blood Flow

Anas Rashid, Enrica Laura Santarcangelo, Silvestro Roatta

Subject: Life Sciences, Other Keywords: doppler; NIRS; hyperventilation; rebreathing; cognitive tasks; hypnotic susceptibility

Online: 24 February 2022 (16:51:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0267.v1

Sustainable Potato Production: A Model of Potato Production at Low Latitude Plateau in Winter, Yunnan Province, China

Pu Jin, Ntirenganya Elie, Zhang Baoju, Zhang Zhenhua, Xiong Shen, Zhang Li, Zhang Hongji, Yu Decai

Subject: Life Sciences, Other Keywords: potato cropping systems; cultivation model; planting density; soil cover; sustainable productivity

Online: 22 February 2022 (10:06:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0171.v1

Time, Mediated through Plant Versatility, is a Better Predictor of Medicinal Status of Alien Plants

Kowiyou Yessoufou, Annie Estelle Ambani, Hosam O. Elansary, Ahmed M. El-Sabrout, Shadi Shokralla

Subject: Life Sciences, Other Keywords: Alien plant species; Availability hypothesis; Versatility hypothesis; Residence time hypothesis; theory driven ethnobotany

Online: 14 February 2022 (10:02:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0153.v1

Trends in Excess Winter Mortality (EWM) From 1900/01 to 2019/20—Evidence for a Complex System of Multiple Long-Term Trends

Rodney P. Jones, Andriy Ponomarenco

Subject: Life Sciences, Other Keywords: winter mortality; trends; season; estimated influenza mortality; pandemic influenza; aging

Online: 10 February 2022 (14:03:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0137.v1

A Critical Analysis of the Hospitalization Network for COVID-19 Patients in Bahia, Brazil in the First Wave of the Pandemic

Marcio Luis Valença Araujo, José Garcia Vivas Miranda, Rodrigo Nogueira Vasconcelos, Elaine Cristina Cambui Barbosa, Raphael Silva Rosário, Márcio Cerqueira de Farias Macedo, Antonio Carlos de Albuquerque Bandeira, Márcia Sao Pedro Leal Souza, Ana Claudia Fernandes Nunes Silva, Aloisio Santos Nascimento Filho, Thiago Barros Murari, Eduardo Manuel de Freitas Jorge, Hugo Saba

Subject: Life Sciences, Other Keywords: Government; Hospitalization; Pandemics; Public policy; Transportation.

Online: 9 February 2022 (11:04:11 CET)

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Preprint ESSAY | doi:10.20944/preprints202201.0121.v2

Public Health Policy Pillars for the Sustainable Elimination of Zoonotic Schistosomiasis

Eva Janoušková, Jessica Clark, Olumayowa Kajero, Sergi Alonso, Poppy H. L. Lamberton, Martha Betson, Joaquín M. Prada

Subject: Life Sciences, Other Keywords: Schistosoma japonicum; Schistosoma mekongi; NTD; epidemiology; economics; sociology; mathematical modelling; zoonotic transmission

Online: 8 February 2022 (14:12:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202202.0051.v1

Machine Learning based Survival Group Prediction in Glioblastoma

Manasa Kalya, Alexander Kel, Andreas Leha, Kamilya Altynbekova, Edgar Wingender, Tim beissbarth

Subject: Life Sciences, Other Keywords: Glioblastoma; survival prediction; Machine Learning; biomarkers; HumanPSDTM; Long-term survivor

Online: 3 February 2022 (12:00:23 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0014.v1

Review of the Effects of Drought Stress on Plants: A Systematic Approach

Priyanka Bijalwan, Meenakshi Sharma, Prashant Kaushik

Subject: Life Sciences, Other Keywords: drought stress; reactive oxygen species; climate change

Online: 1 February 2022 (12:53:40 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0440.v1

Hitting the Bullseye: Endogenous Electrophiles Show Remarkable Nuance in Signaling Regulation

Marcus J.C. Long, Pierre A. Miranda Herrera, Yimon Aye

Subject: Life Sciences, Other Keywords: electrophiles; signaling; profiling; drug mechanism; drug discovery; T-REX

Online: 28 January 2022 (14:57:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0416.v1

Athletes and Coaches Through COVID-19 Pandemic: A Qualitative View of Goal Management

Sergio Costa, Eugenio De Gregorio, Lisa Zurzolo, Giampaolo Santi, Edoardo Giogio Ciofi, Francesco Di Gruttola, Luana Morgilli, Cristina Montesano, Francesca Cavallerio, Maurizio Bertollo, Selenia di Fronso

Subject: Life Sciences, Other Keywords: Goal setting; goal adjustment; lockdown; qualitative survey; reflexive thematic analysis

Online: 27 January 2022 (11:27:26 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202201.0353.v1

GXP: Analyze and Plot Plant Omics Data in Web Browsers

Constantin Eiteneuer, David Velasco, Joseph Atemia, Dan Wang, Andrea Schrader, Roland Pieruschka, Sven Fahrner, Rainer Schwacke, Vanessa Wahl, Ulrich Schurr, Björn Usadel, Asis Hallab

Subject: Life Sciences, Other Keywords: RNA sequencing; metabolomics; data visualization; overrepresentation analysis; cluster analysis; principal component analysis; scientific plotting; Mapman; Mercator

Online: 24 January 2022 (12:36:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0338.v1

Emergent Viral Disease in Alfalfa (Medicago sativa L.) Plots in Cochabamba, Bolivia, a Preliminary Evaluation

Mario Coca Morante, Nilo Acha Molina, Arnold Calani Lucas, Ruddy Meneses Arce

Subject: Life Sciences, Other Keywords: disease incidence; emerging disease; Cultivated forage crops; plant pathology; disease incidence; emerging disease

Online: 24 January 2022 (09:57:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0337.v1

Particle Size of Biochar as Co-composted Fertilizer: Influence on Growth Performance of Lettuce and Concentration of Bioavailable Soil Nutrients under Salinity Stress Conditions

Arifa Malik, Shamim Gul, Abdul Hanan Buriro, Hidayatullah Kakar, Tariq Ziad

Subject: Life Sciences, Other Keywords: Co-composted biochar; drought; NUE; PUE; salinity

Online: 24 January 2022 (09:41:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0329.v1

Transpiration Responses of Herbicide-Resistant and -Susceptible Palmer amaranth [Amaranthus palmeri (S.) Wats.] to Progressively Drying Soil

Koffi Badou-Jeremie Kouame, Mary C. Savin, Gulab Rangani, Thomas R. Butts, Matthew B. Bertucci, Nilda Roma-Burgos

Subject: Life Sciences, Other Keywords: metabolic resistance; drought tolerance; threshold FTSW; stomatal closure; EPSPS gene amplification; S-metolachlor resistance; glyphosate resistance

Online: 21 January 2022 (13:37:55 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0271.v1

The Role of Mesothelin Expression in Serous Ovarian Carcinoma: Impact on Diagnosis, Prognosis, and Therapeutic Target

Giovanna Giordano, Elena Ferioli, Alessandro Tafuni

Subject: Life Sciences, Other Keywords: Mesothelin; serous ovarian carcinoma; target Therapies

Online: 19 January 2022 (12:13:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0236.v1

Effects of Apple Vinegar Addition on Aerobic Deterioration of Fermented High Moisture Maize Using Infrared Thermography as an Indicator

Aylin Agma Okur, Kerem Gozluklu, Ersen Okur, Berrin Okuyucu, Fisun Koc, Mehmet Levent Ozduven

Subject: Life Sciences, Other Keywords: apple vinegar; sodium diacetate; high moisture maize grain; aerobic stability; infrared thermography

Online: 17 January 2022 (15:21:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0208.v1

Advance Directives in Oncology and Haematology: A Long Way to Go. A Narrative Review

Kevin Serey, Amélie Cambriel, Adrien Pollina-Bachellerie, Jean-Pierre Lotz, François Philippart

Subject: Life Sciences, Other Keywords: End of Life; Advance Directives; Advance Care Planning; Intensive Care, Medical Oncology; malignant hemopathy

Online: 14 January 2022 (11:34:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0206.v1

Computational Models in Neurosciences Between Mechanistic and Phenomenological Characterizations

Christophe Gauld, Cédric Brun, Thomas Boraud, Mallory Carlu, Damien Depannemaecker

Subject: Life Sciences, Other Keywords: Computing Methodologies; Computer Simulation; Models, Biological; Models, Theoretical; Theoretical neurosciences

Online: 14 January 2022 (11:28:41 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0196.v1

The Day the Classroom Flipped: Lessons Learned from Interdisciplinary Science Education Online

Marcus J.C. Long, Yimon Aye

Subject: Life Sciences, Other Keywords: education; online; chemical biology; interdisciplinary

Online: 13 January 2022 (18:27:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0174.v1

Pathological Relevance of Post-translationally Modified Alpha-Synuclein (pSer87, pSer129, nTyr39) in Idiopathic Parkinson’s Disease and Multiple System Atrophy

Berkiye Sonustun, Firat M Altay, Catherine Strand, Geshanthi Hondhamuni, Thomas T Warner, Hilal A Lashuel, Rina Bandopadhyay

Subject: Life Sciences, Other Keywords: alpha-synuclein; post-translational modifications; Parkinson’s disease; Multiple system atrophy; Lewy bodies; Lewy neurites; Glial cytoplasmic inclusions; phosphorylation; nitration; immunohistochemistry

Online: 12 January 2022 (14:31:13 CET)

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Preprint ESSAY | doi:10.20944/preprints202201.0121.v1

Public Health Policy Pillars for the Sustainable Elimination of Zoonotic Schistosomiasis

Eva Janoušková, Jessica Clark, Olumayowa Kajero, Sergi Alonso, Poppy H. L. Lamberton, Martha Betson, Joaquín M. Prada

Subject: Life Sciences, Other Keywords: Schistosoma japonicum; Schistosoma mekongi; NTD; epidemiology; economics; sociology; mathematical modelling

Online: 10 January 2022 (13:59:47 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0105.v1

Assessment of Biostimulation Methods based on Chemical Communication in Female Doe Reproduction

Paula R. Villamayor, Julián Gullón, Uxía Yáñez, María Sánchez, Pablo Sánchez-Quinteiro, Paulino Martínez, Luis Quintela

Subject: Life Sciences, Other Keywords: rabbit; biostimulation; reproduction; urine; seminal plasma; chemocommunication; olfaction; pheromones

Online: 10 January 2022 (12:07:54 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0014.v1

Fish Liver Discards as a Source of Long chain Omega-3 Polyunsaturated Fatty Acids

Charlotte Jacobsen, Simone Andrea Warncke, Sussie Hjorth Hansen, Ann-Dorit Moltke Sørensen

Subject: Life Sciences, Other Keywords: Hake; ling; cod; monkfish; coalfish (saithe); omega-3 PUFA

Online: 4 January 2022 (15:29:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0503.v1

Biological Control Strategies of Plant Pathogens

Manisha Arora Pandit, Jitendra Kumar, Saloni Gulati, Neeru Bhandari, Poonam Mehta, Roma Katyal, Charu Dogra Rawat, Vachaspati Mishra, Jasleen Kaur

Subject: Life Sciences, Other Keywords: Plant Pathogen; Biocontrol; Microbes; AMF; Bacteriophages; Microbiome; Sustainable strategies

Online: 31 December 2021 (10:45:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0494.v1

Thinning as Method to Regulate Sweet Cherry Crops – a Review

Krzysztof Rutkowski, Grzegorz P Łysiak

Subject: Life Sciences, Other Keywords: fruit quality; pruning; growth regulation; fruit set; crop value

Online: 30 December 2021 (19:54:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0474.v1

Influence of Probable Precipitation Futures on Strawberries (Fragaria x ananassa): Results from a Simulated Rainfall Experiment

Rachel E. Schattman, Alicyn Smart, Sean Birkel, Haley Jean, Kallol Barai, Yong-Jiang Zhang

Subject: Life Sciences, Other Keywords: Climate change; agroecology; Fragaria x ananassa; precipitation; rainfall simulation

Online: 29 December 2021 (23:20:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0457.v1

Do Human iPSC Derived Cardiomyocytes Cultured on PLA Scaffolds Induce Expression of CD28/CTLA 4 by T Lymphocytes?

David Sergeevichev, Victor Balashov, Victoria Kozyreva, Sophia Pavlova, Maria Vasiliyeva, Alexander Romanov, Elena Chepeleva

Subject: Life Sciences, Other Keywords: graft rejection; iPSC; differentiation; cardiomyocytes; electrospinning; CD28; CTLA-4; immune response

Online: 28 December 2021 (17:37:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0330.v1

The Pivotal Role of Phenological Stage Enhanced by Plant Origin Preparations in the Process of Rhizogenesis of Rosa ‘Hurdal’ Stem Cuttings

Marta Monder, Maciej Niedzielski, Konrad Woliński

Subject: Life Sciences, Other Keywords: biostimulant; carotenoids; chlorophyll; IBA; leaf senescence; NAA; phenology; soluble proteins

Online: 21 December 2021 (12:40:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0311.v1

Trends in the Phenology of Climber Roses under Changing Climate Conditions in Mazovia Lowland in Central Europe

Marta Monder

Subject: Life Sciences, Other Keywords: Central Europe; climate warming; flowering; frost damage; genetic variability; historical roses; climber roses; seasonality; spring phenology; winter hardiness

Online: 20 December 2021 (12:38:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0253.v1

Wings’ Descriptive and Geometric Morphometry Analyses Support Distinct Phlebotomus sergenti Parrot Populations in Central Morocco

Fatima-Zara Abou-Elaaz, Denis Sereno, Oumnia Himmi, Mohamed Ghamizi, Souad Guernaoui

Subject: Life Sciences, Other Keywords: Phlebotomus sergenti; Wing Morphometry; Wing Geomorphomery; Morocco

Online: 15 December 2021 (11:11:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0237.v1

Metabolic Response to Daytime Dry Fasting in Bahá’í Volunteers

Anja Mähler, Carmen Jahn, Lars Klug, Caroline Klatte, Andreas Michalsen, Daniela Koppold-Liebscher, Michael Boschmann

Subject: Life Sciences, Other Keywords: religious fasting; daytime dry fasting; energy expenditure; body composition; microdialysis

Online: 14 December 2021 (13:06:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0175.v2

Surround Modulation Properties of Tectal Neurons in Pigeon Characterized by Moving and Flashed Stimuli

Xiaoke Niu, Shuman Huang, Minjie Zhu, Zhizhong Wang, Li Shi

Subject: Life Sciences, Other Keywords: surround suppression; extra-classical receptive field; optic tectum; size tuning

Online: 10 December 2021 (14:29:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0175.v1

Surround Modulation Properties of Tectal Neurons in Pigeon Characterized by Moving and Flashed Stimuli

Xiaoke Niu, Shuman Huang, Minjie Zhu, Zhizhong Wang, Li Shi

Subject: Life Sciences, Other Keywords: surround suppression; extra-classical receptive field; optic tectum; size tuning

Online: 10 December 2021 (12:22:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0157.v1

Exploring the Genetic Diversity Among Weedy Rice Accessions Differing in Herbicide Tolerance and Allelopathic Potential

Swati Shrestha, Gourav Sharma, Shandrea Stallworth, E. D. Redoña, Te Ming Tseng

Subject: Life Sciences, Other Keywords: crop-improvement; population genetics; weed suppression; sustainable weed management; Palmer amaranth; glyphosate

Online: 9 December 2021 (14:50:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0038.v1

Changes in the Lifestyle in Spanish University Population during the Confinement for COVID-19

Sandra Sumalla-Cano, Tamara Forbes-Hernández, Silvia Aparicio-Obregón, Jorge Crespo, Maria Eléxpuru-Zabaleta, Monica Gracia-Villar, Francesca Giampieri, Iñaki Elío

Subject: Life Sciences, Other Keywords: COVID-19; eating habits; physical activity; MEDAS-14; Emotional eating questionnaire (EEQ) and university population.

Online: 2 December 2021 (12:52:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0011.v1

Dose-Response Study to Evaluate Dicamba Tolerance in Selected Wild Tomato Germplasm

Rouzbeh Zangoueinejad, Mohammad Taghi Alebrahim, Edicarlos Castro, Shandrea Stallworth, Ziming Yue, Richard G Snyder, Te Ming Tseng

Subject: Life Sciences, Other Keywords: auxin herbicide; herbicide tolerance; wild germplasm; GR50; HR50; I50

Online: 1 December 2021 (11:57:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0577.v1

Typical 2-Cys Peroxiredoxins as a Defense Mechanism against Metal-Induced Oxidative Stress in the Solitary Ascidian Ciona robusta

Laura Drago, Diana Ferro, Rigers Bakiu, Loriano Ballarin, Gianfranco Santovito

Subject: Life Sciences, Other Keywords: Ciona robusta; tunicate; metals; typical 2-Cys peroxiredoxins; antioxidant enzymes.

Online: 30 November 2021 (17:58:47 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202111.0575.v1

First Report on the Occurrence of Benzoxazinoids in an Invasive Weed Plant, Woolly Cupgrass (Eriochloa villosa (Thunb./Kunth)

Peter Makleit, Szilvia Veres, Arnold Szilágyi

Subject: Life Sciences, Other Keywords: benzoxazinoids; Eriochloa villosa, wolly cupgrass; new occurrence

Online: 30 November 2021 (15:18:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0553.v1

Physical Activity and BMI before and after the Situation Caused by COVID-19 in Upper Primary School Pupils in Czech Republic

Jana Pysna, Jiří Suchý, Ladislav Pyšný, David Cihlář, Dominika Petrů, Lenka Hajer Müllerová, Luděk Čtvrtečka

Subject: Life Sciences, Other Keywords: physical activity; Body Mass Index; COVID-19; pupils; health; lifestyle; sport; obesity

Online: 30 November 2021 (08:46:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0452.v1

Southern African Large Frame Indigenous Veld Goat and Boer Goat Wether and Buck Tenderness and Colour of Six Muscles

Gertruida L. van Wyk, Louwrens C. Hoffman, Phillip E. Strydom, Lorinda Frylinck

Subject: Life Sciences, Other Keywords: Cape Lob Ear; Cape Speckled; meat goat breeds; meat tenderness; meat colour; collagen; chevon

Online: 24 November 2021 (10:47:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0444.v1

Ficus thonningii Stem Bark Extracts Prevent High Fructose Diet Induced Increased Plasma Triglyceride Concentration, Hepatic Steatosis and Inflammation in Growing Sprague-Dawley Rats

Eliton Chivandi, Yvonne Mhosva, Trevor Nyakudya, Pilani Nkomozepi

Subject: Life Sciences, Other Keywords: F. thonningii; ethnomedicine; obesity; lipid profile; liver disease

Online: 24 November 2021 (08:17:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0443.v1

The PACAP/PAC1 Receptor System and Feeding

Keerthana Sureshkumar, Andrea Saenz, Syed Muzzammil Ahmad, Kabirullah Lutfy

Subject: Life Sciences, Other Keywords: PACAP; PAC1; Homeostatic; Hedonic; Food Intake; Signaling; Neuroanatomical Site

Online: 24 November 2021 (08:15:49 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0419.v1

Facing the Harsh Reality of Access and Benefit Sharing (ABS) Legislation

Frank Michiels, Ulrich Feiter, Stéphanie Paquin-Jaloux, Diana Jungmann, Axel Braun, Mary Ann P. Sayoc, Ricard Armengol, Markus Wyss, Bruno David

Subject: Life Sciences, Other Keywords: Convention on Biological Diversity; Access and Benefit Sharing; Nagoya Protocol; industry perspective

Online: 23 November 2021 (10:46:33 CET)

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LIFE SCIENCES