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Preprint REVIEW | doi:10.20944/preprints202306.0166.v1

Vibrational Spectroscopy of Phytochromes

Peter Hildebrandt

Subject: Biology And Life Sciences, Biophysics Keywords: Raman, IR, spectroscopy, phytochrome, tetrapyrrole, photoswitch

Online: 2 June 2023 (09:01:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202306.0032.v1

Identification Mechanism of BACE1 on Inhibitors Probed by Using Multiple Separate Molecular Dynamics Simulations and Comparative Calculations of Binding Free Energies

Yinwen Wang, Fen Yang, Dongliang Yan, Yalin Zeng, Benzheng Wei, Jianzhong Chen, Weikai He

Subject: Biology And Life Sciences, Biophysics Keywords: BACE1; Alzheimer's disease; molecular dynamics simulations, SIE; MM-GBSA

Online: 1 June 2023 (04:57:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.2030.v1

Quality Assessment of Graphene for Biosensors Application

Natalia M. Shmidt, Evgeniya I. Shabunina, Ekaterina A. Gushchina, Vasiliy N. Petrov, Ilya A. Eliseev, Sergey P. Lebedev, Sergei Iu. Priobrazhenskii, Elena M. Tanklevskaya, Mikhail V. Puzyk, Alexander D. Roenkov, Alexander S. Usikov, Alexander A. Lebedev

Subject: Biology And Life Sciences, Biophysics Keywords: graphene chip; surface topography; photoresist residues; low-frequency noise

Online: 30 May 2023 (03:57:20 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1930.v1

Molecular Biological Effects of Weak Low-frequency Magnetic Fields: Current State and Future Prospects

Viacheslav V. Krylov

Subject: Biology And Life Sciences, Biophysics Keywords: low-frequency magnetic fields; ion parametric resonance; calcium; cryptochrome; mitochondria; biochemical oscillations

Online: 26 May 2023 (11:27:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1868.v1

Bovine Lactoferrin Loaded Magnetic-Responsive Plasmonic Lipo-Somes for Therapeutic Applications

Mélanie Pereira, Ana Rita O. Rodrigues, Leslie Amaral, Manuela Côrte-Real, Cátia Santos-Pereira, Elisabete M. S. Castanheira

Subject: Biology And Life Sciences, Biophysics Keywords: Plasmonic magnetoliposomes; Dual hyperthermia; Bovine lactoferrin; Cytotoxicity; Biological activity

Online: 26 May 2023 (05:40:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.1267.v1

The Motion Paradigm of Pre-dock Zearalenone Hydrolase Predicts with Molecular Dynamic and the Docking One with Umbrella Sampling

Xi-Zhi Hong, Zheng-Gang Han, Jiang-Ke Jiang, Yi-Han Liu

Subject: Biology And Life Sciences, Biophysics Keywords: Zearalenone hydrolase; Neural Relational Inference; Umbrella sampling; MMPBSA; bmDCA

Online: 18 May 2023 (04:58:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.1045.v1

Mechanobiological Analysis of Nanoparticle Toxicity

Abdurazak Aman Ketebo, Shahab Ud Din, Gwang Lee, Sungsu Park

Subject: Biology And Life Sciences, Biophysics Keywords: Nanoparticles; nanotoxicity; mechanobiology; cell cytoskeleton; rigidity sensing

Online: 15 May 2023 (12:39:53 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.0607.v2

A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters

Spyros Papageorgiou

Subject: Biology And Life Sciences, Biophysics Keywords: Hox gene collinearity; temporal collinearity; Noether theory; self similarity; double strand break; split Ηox cluster; limb growth

Online: 11 May 2023 (04:34:03 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202305.0607.v1

A Model That Reproduces an Empirical Rule Distinguishing the Developmental Path of Complete Hox Gene Clusters From Split Clusters

Spyros Papageorgiou

Subject: Biology And Life Sciences, Biophysics Keywords: Hox gene collinearity; temporal collinearity; Noether theory; self similarity; double strand break; split Ηox cluster; limb growth

Online: 9 May 2023 (08:38:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202305.0503.v1

Emerging Quantitative Biochemical, Structural and Biophysical Methods to Study Ribosome and Protein-RNA Complex Assembly

Kavan Gor, Olivier Duss

Subject: Biology And Life Sciences, Biophysics Keywords: RNP assembly; ribosome assembly; protein-RNA interactions; RNA folding; assembly intermediates; in vitro reconstitutions; mass spectrometry; single-molecule fluorescence microscopy; cryo-electron microscopy; RNA structure probing

Online: 8 May 2023 (10:01:55 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202305.0275.v1

Chelator PBT2 Forms a Ternary Cu²⁺ Complex with β-Amyloid that has High Stability but Low Specificity

Simon Drew

Subject: Biology And Life Sciences, Biophysics Keywords: 8-hydroxyquinoline; PBT2; amyloid; copper; terdentate; ternary; antimicrobial

Online: 5 May 2023 (02:36:19 CEST)

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The metal chelator PBT2 (5,7-dichloro-2-[(dimethylamino)methyl]-8-hydroxyquinoline) acts as a terdentate ligand capable of forming binary and ternary Cu2+ complexes. It was clinically trialed as an Alzheimer’s disease (AD) therapeutic but failed to progress beyond phase II. The β-amyloid (Aβ) peptide associated with AD was recently concluded to form a unique Cu(Aβ) complex that is inaccessible to PBT2. Herein, it is shown that the species ascribed to this binary Cu(Aβ) complex in fact corresponds to ternary Cu(PBT2)NIm[Aβ] complexes formed by anchoring of Cu(PBT2) on imine nitrogen (NIm) donors of His side chains. The primary site of ternary complex formation is His6, having a conditional stepwise formation constant at pH 7.4 (K [M−1] ) of log K = 6.4 ± 0.1, and a second site is supplied by His13 or His14 (log K = 4.4 ± 0.1). The stability of Cu(PBT2)NIm[H13/14] is comparable with that of the simplest ternary complexes involving free imidazole (log K = 4.22 ± 0.09) and histamine (log K = 4.00 ± 0.05). The 100-fold larger formation constant for Cu(PBT2)NIm[H6] indicates that outer-sphere ligand–peptide interactions strongly stabilize its structure. Despite the relatively high stability of Cu(PBT2)NImH6, PBT2 is a promiscuous Cu2+-binding ligand capable of forming a ternary Cu(PBT2)NIm complex with any ligand containing NIm donor. These ligands include histamine, L-His, and ubiquitous His side chains of peptides and proteins in the extracellular milieu, whose combined effect should outweigh that of a single Cu(PBT2)NIm[H6] complex regardless of its stability. We therefore conclude that PBT2 is capable of accessing Cu(Aβ) complexes with high stability but not specificity. The results have implications for future AD therapeutic strategies and understanding the role of PBT2 in the bulk transport of transition metal ions. Given the repurposing of PBT2 as a drug for breaking antibiotic resistance, ternary Cu(PBT2)NIm and analogous Zn(PBT2)NIm complexes may be relevant to its antimicrobial properties.

Preprint ARTICLE | doi:10.20944/preprints202305.0246.v1

Structure and Optical Anisotropy of Spider Scales and Silk: Use of Chromaticity and Azimuth Colors

Denver P Linklater, Arturas Vailionis, Meguya Ryu, Shuji Kamegaki, Junko Morikawa, Haoran Mu, Daniel Smith, Pegah Maasoumi, Rohan Ford, Tomas Katkus, Sean Blamires, Toshiaki Kondo, Yoshiaki Nishijima, Daniel Moraru, Michael Shribak, Andrea O’Connor, Elena Ivanova, Soon Ng, Masuda Hideki, Saulius Juodkazis

Subject: Biology And Life Sciences, Biophysics Keywords: Anisotropy; polarisation analysis; Stokes parameters; polarimetry

Online: 4 May 2023 (09:13:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0170.v1

Evidence for the I-Shaped Dimers of a Plant Chloroplast F_OF₁-ATP Synthase in Response to Changes in Ionic Strength

Stepan D. Osipov, Yury L. Ryzhykau, Egor V. Zinovev, Andronika V. Minaeva, Sergey D. Ivashchenko, Dmitry P. Verteletskiy, Vsevolod V. Sudarev, Daria D. Kuklina, Mikhail Yu. Nikolaev, Yury S. Semenov, Yuliya A. Zagryadskaya, Ivan S. Okhrimenko, Margarita S. Gette, Alexander I. Kuklin, Valentin Ivanovich, Vladimir N. Uversky, Alexey V. Vlasov

Subject: Biology And Life Sciences, Biophysics Keywords: FOF1-ATP synthase; chloroplasts; dimers; small-angle scattering; membrane proteins

Online: 4 May 2023 (03:21:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202305.0125.v1

Bioimetics with Trade-Offs

Julian Francis Vincent

Subject: Biology And Life Sciences, Biophysics Keywords: trade-off; dialectic; TRIZ; Inventive Principle; wood wasp ovipositor; intracranial endoscope; Pareto curve

Online: 3 May 2023 (09:44:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0837.v1

Prognostic Performance of Three Lymph Node Staging Systems on Gastric Signet Ring Cell Carcinoma

Limin Zhang, Qi You, Bao Liu

Subject: Biology And Life Sciences, Biophysics Keywords: Gastric signet ring cell carcinoma; lymph node metastases; LODDS; prognosis

Online: 24 April 2023 (09:00:47 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202304.0829.v1

The Influence of Glycerol Flow through a Shielded Coil on an Enzyme Placed Near Its Side

Yuri D. Ivanov, Ivan D. Shumov, Andrey F. Kozlov, Maria O. Ershova, Anastasia A. Valueva, Irina A. Ivanova, Vadim Y. Tatur, Andrei A. Lukyanitsa, Nina D. Ivanova, Vadim S. Ziborov

Subject: Biology And Life Sciences, Biophysics Keywords: atomic force microscopy; horseradish peroxidase; enzyme aggregation; enzymatic activity; tribo-electric effect; fluid flow

Online: 24 April 2023 (06:14:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202304.0528.v1

Sample Delivery Systems for Serial Femtosecond Crystallography at PAL-XFEL

Jaehyun Park, Ki Hyun Nam

Subject: Biology And Life Sciences, Biophysics Keywords: serial femtosecond crystallography; X-ray free electron laser; sample delivery; injector; fixed-target scanning; hybrid method

Online: 19 April 2023 (03:22:22 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202303.0042.v1

Structured Illumination Microscopy Improves Spot Detection Performance in Spatial Transcriptomics

Alejandro Linares, Carlo Brighi, Sergio Espinola, Francesco Bacchi, Álvaro H. Crevenna

Subject: Biology And Life Sciences, Biophysics Keywords: Structured illumination; Spatial transcriptomics; Super-resolution; Gene expression; In situ sequencing; Deconvolution microscopy

Online: 2 March 2023 (10:42:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202302.0516.v1

The Confound of Hemodynamic Response Function Variability in Resting-State Functional MRI Studies

D Rangaprakash, Robert Barry, Gopikrishna Deshpande

Subject: Biology And Life Sciences, Biophysics Keywords: BOLD fMRI; HRF; resting state connectivity; aging; sex differences; confound

Online: 28 February 2023 (09:32:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0389.v1

Entropic Dynamics in a Theoretical Framework for Biosystems

Richard L Summers

Subject: Biology And Life Sciences, Biophysics Keywords: entropic dynamics; biosystems; Kullback Principle of Minimum Information Discrimination; biocontinuum; information geometry

Online: 22 February 2023 (15:32:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints202302.0059.v1

Exploring the Unbinding Mechanism of Drugs from SERT via Molecular Dynamics Simulation and its Implication in Antidepressants

Xin-Guan Tan, Xue-Feng Liu, Xin Li, Ming-Hui Pang, Yu-Qing Wang, Yun-Jie Zhao

Subject: Biology And Life Sciences, Biophysics Keywords: hSERT; comprehensive molecular dynamics (MD) simulation; drug design; MM/GBSA

Online: 3 February 2023 (06:16:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0346.v1

Cholesterol in Class C GPCRs: Role, Relevance, and Localization

Ugochi H. Isu, Shadi A. Badiee, Ehsaneh Khodadadi, Mahmoud Moradi

Subject: Biology And Life Sciences, Biophysics Keywords: G-protein-coupled-receptors; GPCRs; Membrane protein; Protein-lipid interactions; Cholesterol; Class C GPCRs

Online: 19 January 2023 (06:32:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0344.v1

A Tale of 12 Tails: Katanin Severing Activity Affected by Carboxy-Terminal Tail Sequences

K. Alice Lindsay, Nedine Abdelhamid, Shehani Kahawatte, Ruxandra I. Dima, Dan L. Sackett, Tara M. Finegan, Jennifer L. Ross

Subject: Biology And Life Sciences, Biophysics Keywords: microtubule-severing enzyme; tubulin isotypes; tubulin code; post-translational modifications; katanin; microtubule-associated protein

Online: 19 January 2023 (03:16:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0259.v1

Magneto-encephalography Scan under Color-tailored Illumination

Charitha Weerasuriya, Soon Hock Ng, Will Woods, Tom Johnstone, Pranciskus Vitta, Laila Hugrass, Saulius Juodkazis

Subject: Biology And Life Sciences, Biophysics Keywords: MEG; LED; color perception

Online: 16 January 2023 (01:36:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202301.0201.v1

CFD Computation of Flow Fractional Reserve (FFR) in Coronary Artery Trees Using a Novel Physiologically Based Algorithm (PBA) Under 3D Steady and Pulsatile Flow Conditions

Nursultan Alzhanov, Eddie Y. K. Ng, Xiaohui Su, Yong Zhao

Subject: Biology And Life Sciences, Biophysics Keywords: FFR, Blood Flow Simulation, coronal stenosis, Coronary Computed Tomography Angiography (CCTA), OpenFOAM

Online: 11 January 2023 (11:56:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202301.0004.v1

Pre-Molten, Wet, and Dry Molten Globules En Route to the Functional State of Proteins

Munishwar Nath Gupta, Vladimir N. Uversky

Subject: Biology And Life Sciences, Biophysics Keywords: Baroenzymology; Cryoenzymology; Intrinsic disorder; Intrinsically disordered proteins; Macromolecular crowding; Nanomaterials; Partially folded intermediate; Protein denaturation; Protein engineering; Protein flexibility; Protein folding; Protein function; Protein stability; Protein structure; Protein refolding; Protein unfolding

Online: 3 January 2023 (06:48:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202212.0201.v1

Waves, Protein Synthesis and Resonance in the Brain: a New Approach for a Long Term Memory

Lucian Muresan, Andrei Jalba

Subject: Biology And Life Sciences, Biophysics Keywords: Waves; Protein Synthesis; Resonance; Long Term Memory

Online: 12 December 2022 (12:11:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0046.v1

Oscillations in the Dentate Gyrus as a Tool for the Functioning of the Hippocampus: Healthy and Epileptic Brain

Valentina Kitchigina, Liubov Shubina

Subject: Biology And Life Sciences, Biophysics Keywords: oscillations, theta rhythm, gamma rhythm, coherence, temporal lobe epilepsy

Online: 2 December 2022 (10:11:23 CET)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202211.0477.v1

Inertial Sensors-Based Estimation of Temporal Events in Skating Sub-Techniques While In-Field Roller Skiing

Frédéric Meyer, Magne Lund-Hansen, Jan Kocbach, Trine M. Seeberg, Øyvind Sandbakk, Andreas Austeng

Subject: Biology And Life Sciences, Biophysics Keywords: cross-country skiing; temporal event detection; wearable sensors; field analysis

Online: 25 November 2022 (10:09:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints202211.0313.v1

Binding of Specific S100 Proteins Inhibits Activity of Tumor Necrosis Factor

Alexey S. Kazakov, Marina Y. Zemskova, Gleb K. Rystsov, Alisa A. Vologzhannikova, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Subject: Biology And Life Sciences, Biophysics Keywords: cytokine; Tumor necrosis factor; S100 protein; protein–protein interaction; inflammatory diseases

Online: 16 November 2022 (13:12:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0186.v3

Neural Assemblies as Precursors for Brain Function

Kieran Greer

Subject: Biology And Life Sciences, Biophysics Keywords: neural; brain; structural intelligence; cell expression; evolution

Online: 4 November 2022 (09:43:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202210.0457.v1

An Overlooked Hepcidin-cadmium Connection

Dawid Płonka, Marta D. Wiśniewska, Manuel D Peris-Díaz, Artur Krężel, Arkadiusz M. Bonna, Wojciech Bal

Subject: Biology And Life Sciences, Biophysics Keywords: Hepcidin; prohepcidin; cadmium; affinity constant; metallothionein; MT2A

Online: 28 October 2022 (13:00:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0386.v1

Omicron BA.2.75 Sublineage Follows the Expectations of the Evolution Theory: Less Negative Gibbs Energy of Biosynthesis Indicates Decreased Pathogenicity

Marko Popovic

Subject: Biology And Life Sciences, Biophysics Keywords: COVID-19; SARS-CoV-2; Pandemic; Empirical formula; Growth stoichiometry; Thermodynamic properties of biosynthesis; Multiplication rate; Enthalpy; Entropy; Gibbs energy

Online: 25 October 2022 (10:53:13 CEST)

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Preprint ESSAY | doi:10.20944/preprints202210.0326.v1

Biothermodynamic Key Opens the Door of Life Sciences: Bridging the Gap between Biology and Thermodynamics

Marko Popovic

Subject: Biology And Life Sciences, Biophysics Keywords: biology; thermodynamics; biothermodynamics; entropy; Gibbs energy

Online: 21 October 2022 (09:58:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0276.v1

UHF-Dielectrophoresis Microfluidic Lab-on-a-Chip to Detect the Transformation Potential of Extracellular Vesicles Derived From Cancer Stem Cells

Élodie Barthout, Élisa Lambert, Céline Hervieu, Sofiane Saada, Rémi Manczak, Julie Pannequin, Arnaud Pothier, Claire Dalmay, Fabrice Lalloué, Muriel Mathonnet, Barbara Bessette

Subject: Biology And Life Sciences, Biophysics Keywords: colorectal cancer; cancer stem cells; extracellular vesicles; high frequency dielectrophoresis; mi-crofluidic lab-on-a-chip

Online: 19 October 2022 (10:03:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0186.v2

Neural Assemblies as Precursors for Brain Function

Kieran Greer

Subject: Biology And Life Sciences, Biophysics Keywords: neural; brain; structure; function; process; cell expression

Online: 18 October 2022 (02:37:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202210.0186.v1

Neural Assemblies as Precursors for Brain Function

Kieran Greer

Subject: Biology And Life Sciences, Biophysics Keywords: neural; brain; structure; function; process; cell expression

Online: 13 October 2022 (05:50:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0450.v1

Intrinsic Disorder as a Natural Preservative: High Levels of Intrinsic Disorder in Proteins Found in the 2,600-Year-Old Human Brain

Aaron Mohammed, Vladimir N. Uversky

Subject: Biology And Life Sciences, Biophysics Keywords: Heslington brain; intrinsically disordered protein; intrinsically disordered region; binding-induced folding; disorder-to-order transition

Online: 29 September 2022 (03:49:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0442.v1

Different Intermolecular Interactions Drive Nonpathogenic Liquid-Liquid Phase Separation and Potentially Pathogenic Fibril Formation by TDP-43

Yu-teng Zeng, Lu-lu Bi, Xiao-feng Zhuo, Lingyun Yang, Bo Sun, Jun-xia Lu

Subject: Biology And Life Sciences, Biophysics Keywords: TDP-43; Liquid-liquid phase separation; Solution-state NMR

Online: 28 September 2022 (12:22:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0395.v1

Non-invasive Probing of Winter Dormancy via Time-frequency Analysis of Induced Chlorophyll Fluorescence in Deciduous Plants as Exemplified by Apple (Malus × domestica Borkh.)

Boris Shurygin, Ivan Konyukhov, Sergei Khruschev, Alexei Solovchenko

Subject: Biology And Life Sciences, Biophysics Keywords: chilling requirement; chlorophyll fluorescence; non-photochemical quenching; PAM; photoprotection; stress resilience; winter dormancy

Online: 26 September 2022 (11:01:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0319.v1

Calcium-Bound S100P Protein is a Promiscuous Binding Partner of the Four-Helical Cytokines

Alexey S. Kazakov, Evgenia I. Deryusheva, Maria E. Permyakova, Andrey S. Sokolov, Victoria A. Rastrygina, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Subject: Biology And Life Sciences, Biophysics Keywords: cytokine; S100 protein; S100P; protein–protein interaction

Online: 21 September 2022 (09:45:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202209.0119.v1

A Versatile Suspended Lipid Membrane System for Probing Membrane Remodeling and Disruption

Achinta Sannigrahi, Vishwesh Haricharan Rai, Muhsin Vannan Chalil, Debayani Chakraborty, Subrat Kumar Meher, Rahul Roy

Subject: Biology And Life Sciences, Biophysics Keywords: Suspended bilayer; Pore-forming toxin; Cytolysin A; Virus fusion; Pore formation

Online: 8 September 2022 (07:45:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0327.v1

Arrangement of Hydrogen Bonds in Aqueous Solutions of Different Globular Proteins

Amber R. Titus, Pedro P. Madeira, Luisa A. Ferreira, Alexander I. Belgovskiy, Elizabeth K. Mann, J. Adin Mann, William V. Meyer, Anthony E. Smart, Vladimir N. Uversky, Boris Y. Zaslavsky

Subject: Biology And Life Sciences, Biophysics Keywords: Fourier Transform Infrared spectroscopy; water structure; hydrogen bonds; protein solution; solvent properties

Online: 18 August 2022 (03:25:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202208.0213.v1

Towards a General Intermolecular Binding Affinity Calculator

Wei Li

Subject: Biology And Life Sciences, Biophysics Keywords: intermolecular binding affinity; drug target binding affinity; computer-aided drug design (CADD); artificial intelligence-integrated drug discovery (AIDD); machine learning

Online: 11 August 2022 (08:40:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0182.v1

Low Dose Rate Radiation Induced Secretion of TGF-β3 Together With an Activator in Small Extracellular Vesicles Modifies Low Dose Hyper-Radiosensitivity Through ALK1 Binding

Ingunn Hanson, Kathinka Elinor Pitman, Ursula Altanerova, Čestmír Altaner, Eirik Malinen, Nina Frederike Jeppesen Edin

Subject: Biology And Life Sciences, Biophysics Keywords: ADAM; Adaptive response; ALK1; ALK5; Bystander effects; Hyper-radiosensitive response; Low-dose radiation; Low dose rate; MMP; TGF-β3

Online: 12 July 2022 (09:25:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0120.v1

Using Brains as Sensors of the Magnetic Fields Produced by Other Brains

Énora Jeuland, Matthieu Lenne, Florence Jarry, Jacques Bruno Debruille

Subject: Biology And Life Sciences, Biophysics Keywords: Brain; sensitivity to EMFs; EEG; ERPs; N400; LPP; joint processing effects (JPEs)

Online: 7 July 2022 (09:19:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0058.v1

Heparan Sulfate Facilitates Binding of hIFNγ to its Cell-Surface Receptor hIFNGR1

Elisaveta Miladinova, Elena Lilkova, Elena Krachmarova, Kristina Malinova, Peicho Petkov, Nevena Ilieva, Genoveva Nacheva, Leandar Litov

Subject: Biology And Life Sciences, Biophysics Keywords: human interferon gamma; human interferon gamma receptor; receptor binding; heparan sulfate; co-receptor; molecular dynamics simulations; sodium chlorate; kynurenine antiproliferative assays; hIFNγ signalling

Online: 5 July 2022 (04:43:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202207.0031.v1

Stochastic Population Dynamics of Cancer Stemness and Adaptive Response to Therapies

Paras Jain, Atchuta Srinivas Duddu, Mohit Kumar Jolly

Subject: Biology And Life Sciences, Biophysics Keywords: Cell-state transitions; Phenotypic plasticity; Cancer Stem Cells; Intratumoral heterogeneity; Lamarckian Induction; Drug resistance

Online: 4 July 2022 (04:56:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0309.v1

Study of Cell Migration under Mechanical Confinement in Microfluidic Lab-on-a-Chip

Federico Sala, Carlotta Ficorella, Roberto Osellame, Josef A. Käs, Rebeca Martínez Vázquez

Subject: Biology And Life Sciences, Biophysics Keywords: lab-on-a-chip; cell migration; microfluidics; PDMS; hydrogels; femtosecond laser microfabrication; two-photon polymerization

Online: 22 June 2022 (08:21:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints202206.0253.v1

Structural Bioinformatics and Deep Learning of Metalloproteins: Recent Advances and Applications

Claudia Andreini, Antonio Rosato

Subject: Biology And Life Sciences, Biophysics Keywords: Bioinorganic chemistry; metal-binding; structural biology; zinc; iron; copper; transition metals

Online: 17 June 2022 (09:30:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0228.v1

Use of the Catastrophe Model to Preliminarily Explore the Principles of Multicellular Organization

Zheming Cao, Weidong Ding, Jun Qiang, Meiyao Wang, Haojun Zhu

Subject: Biology And Life Sciences, Biophysics Keywords: catastrophe model; multicellular organization; IPS cell

Online: 16 June 2022 (03:51:39 CEST)

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Thermodynamic studies consider living entities as dissipative structures. Organisms maintain and develop an orderly structure by exchanging matter, energy, and entropy with the surrounding environment; thus, maintaining life and growth. For a single cell, the temperature, volume, content concentration, and content complexity are four control variables. For warm-blooded animals, both temperature and content concentration are assumed to be constant, and only volume and content complexity, i.e., various proteins, nucleic acids, and small molecular substances in the cell and their interactions, are considered as acting variables. Thus, the potential function of a single cell should conform to the cusp catastrophe model. As the studies on the specific mathematical models of the relationship between the volume and content complexity are not available, we could not propose specific methods for the specific variants of the potential function of this cusp catastrophe model. We could only present our approximate results based on the basic characteristics of the cusp catastrophe model. We speculated that when a single cell is in a stable state, it cannot undergo differentiation, dedifferentiation, and division. These behaviors occur only when the cell enters an unstable state. Based on this speculation, we divided somatic cells of warm-blooded animals into two types, namely stable cells and non-steady cells. If we consider a warm-blooded animal as a whole dissipative structure, its control variables should have steady-state cells, non-steady-state cells, and negative entropy input. If we assume that the negative entropy input is constant, the proportion of non-steady cells and the total number of cells can be used as the control variables of the potential function. For warm-blooded animals, their potential function also conforms to the cusp catastrophe model. Because the studies on the relationship between the proportion of non-steady-state cells and the total cell number are rare, we could not propose specific methods for the variation of the potential function of this cusp catastrophe model. We could only present our approximate results according to the basic characteristics of the cusp catastrophe model. We speculated that as individuals, animals should be in a stable state during development. Once they enter an unstable state, they will fall ill or die. For humans, the proportion of non-steady cells decreases during the growth process from a fertilized egg to old age. From the fertilized egg to adulthood, the total cell number increases; however, in old age, the total cell number begins to decrease gradually. The entire developmental curve will gradually enter an unstable state. We speculated that once the developmental curve of a human enters an unstable state, it is death for the elderly.

Preprint ARTICLE | doi:10.20944/preprints202206.0199.v1

Disruption of a Conservative Motif in the C-Terminal Loop of the KCNQ1 Channel Causes LQT Syndrome

Maria Karlova, Denis V. Abramochkin, Ksenia B. Pustovit, Tatiana Nesterova, Valery Novoseletsky, Gildas Loussouarn, Elena Zaklyazminskaya, Olga S. Sokolova

Subject: Biology And Life Sciences, Biophysics Keywords: KCNQ1; Kv7.1; IKs; patch-clamp; inherited channelopathy; LQTS

Online: 14 June 2022 (08:42:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0138.v1

Investigations of the Influence the Sleep Disorders on Postural Stability in Young Men

Anna Tetych, Grażyna Olchowik, Jan Warchol

Subject: Biology And Life Sciences, Biophysics Keywords: posturography; insomnia; sleep disorders

Online: 9 June 2022 (08:11:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0392.v1

Common Structural Pattern for Flecainide Binding in Atrial-Selective K_v1.5 and Na_v1.5 Channels: A Computational Approach

Yuliet Mazola, José C.E. Márquez-Montesinos, David Ramírez, Leandro Zúñiga, Niels Decher, Ursula Ravens, Vladimir Yarov-Yarovoy, Wendy González

Subject: Biology And Life Sciences, Biophysics Keywords: atrial-fibrillation; multi-target; drug promiscuity; druggable binding site; flecainide; Nav1.5; Kv1.5; binding site comparison; polypharmacology

Online: 30 May 2022 (10:10:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0488.v6

The Solar System: Nature and Mechanics

Mario Ljubičić

Subject: Biology And Life Sciences, Biophysics Keywords: solar system; complete relativity; nature; mechanics

Online: 23 May 2022 (05:50:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0255.v1

hERG Blockade Prediction by Combining Site Identification by Ligand Competitive Saturation and Physicochemical Properties

Himanshu Goel, Wenbo Yu, Alexander D. MacKerell Jr.

Subject: Biology And Life Sciences, Biophysics Keywords: SILCS; hERG channel; Physicochemical properties; Multiple linear regression; FragMaps

Online: 19 May 2022 (08:46:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0234.v1

Physical Analysis of SARS-CoV-2 Routes: from Primary Production and Emissions to Exposures and COVID-19 Infection

Gjalt Huppes, Ruben Huele

Subject: Biology And Life Sciences, Biophysics Keywords: SARS-CoV-2; COVID-19; virions mass balance; spatial modelling of toxics concentrations; human exposure to airborne substances; Substance Flow Analysis (SFA); environmental routes of toxic viruses; primary production of SARS-2 virions

Online: 17 May 2022 (14:19:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0200.v1

The Membrane Potential Has a Primary Key Equation

Hirohisa Tamagawa, Toi Nakahata, Ren Sugimori, Bernard Delalande

Subject: Biology And Life Sciences, Biophysics Keywords: membrane potential; Nernst equation; ion adsorption; surface charge; surface potential

Online: 16 May 2022 (08:12:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0171.v1

Principal Component Analysis and Related Methods for Investigating the Dynamics of Biological Macromolecules

Akio Kitao

Subject: Biology And Life Sciences, Biophysics Keywords: principal component analysis; collective variables; molecular dynamics; energy landscape; solvent effects; linear response theory; independent component analysis

Online: 12 May 2022 (10:53:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0006.v1

Flexible Multiplane Structured Illumination Microscope With a Four-Camera Detector

Karl A Johnson, Daniel Noble, Rosa Machado, Guy M. Hagen

Subject: Biology And Life Sciences, Biophysics Keywords: structured illumination; fluorescence; brain; multi-camera

Online: 4 May 2022 (12:24:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202204.0156.v1

Living Cell’s Feeling of Holes: The Mathematics of Cavities in Biophysical Structures

Arturo Tozzi

Subject: Biology And Life Sciences, Biophysics Keywords: nanovesicles; flow; homology; vortex; Betti number; Borsuk–Ulam theorem

Online: 18 April 2022 (06:14:33 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202203.0146.v1

Expansion Microscopy on Saccharomyces cerevisiae

Artemis G. Korovesi, Leonor Morgado, Marco Fumasoni, Ricardo Henriques, Hannah Heil, Mario Del Rosario

Subject: Biology And Life Sciences, Biophysics Keywords: expansion microscopy; yeast; Saccharomyces cerevisiae; super-resolution

Online: 10 March 2022 (10:51:02 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202203.0079.v1

Does Long-Term Indoor Exposure to Thermoneutral Environments Impair Human Body Thermal Acclimatization Abilities?

Faming Wang

Subject: Biology And Life Sciences, Biophysics Keywords: thermal neutral; acclimation; acclimatization; adaptation; health; indoor environments

Online: 4 March 2022 (11:23:44 CET)

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Preprint ARTICLE | doi:10.20944/preprints202203.0050.v1

Structure (Epicardial Stenosis) and Function (Microvascular Dysfunction) that Influences Coronary Fractional Flow Reserve Estimation

Jermiah J. Joseph, Clara Sun, Ting-Yim Lee, Daniel Goldman, Sanjay R. Kharche, Chris W. McIntyre

Subject: Biology And Life Sciences, Biophysics Keywords: Coronary vasculature; lumped parameter model; fractional flow reserve; computational cardiology

Online: 2 March 2022 (12:34:43 CET)

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Preprint REVIEW | doi:10.20944/preprints201902.0122.v4

Leishmania Proteomics: An in Silico Perspective

Carlos A. Padilla, María J. Álvarez, Aldo F. Combariza

Subject: Biology And Life Sciences, Biophysics Keywords: Leishmania; leishmaniasis; Theoretical Physics and Chimistry; Molecular Dynamics

Online: 1 March 2022 (12:58:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0354.v2

Non-equilibrium Thermodynamic Foundations of the Origin of Life

Karo Michaelian

Subject: Biology And Life Sciences, Biophysics Keywords: origin of life; disspative structuring; prebiotic chemistry; abiogenisis; non-equilibrium thermodynamics; thermodynamic dissipation theory

Online: 31 January 2022 (13:13:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0354.v1

Non-equilibrium Thermodynamic Foundations of the Origin of Life

Karo Michaelian

Subject: Biology And Life Sciences, Biophysics Keywords: origin of life; disspative structuring; prebiotic chemistry; abiogenisis; non-equilibrium thermodynamics; thermodynamic dissipation theory

Online: 24 January 2022 (12:43:49 CET)

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Preprint HYPOTHESIS | doi:10.20944/preprints202104.0606.v2

Role of a-Synuclein in Cell Biology: A Hypothesis and its Implications in Neurodegenerative Diseases

Renu Minda

Subject: Biology And Life Sciences, Biophysics Keywords: Parkinson’s disease; alpha-synuclein; Lewy bodies; phase transition; thermodynamics; and mitochondria

Online: 10 January 2022 (12:23:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0046.v1

Veratridine Can Bind to a Site at the Mouth of the Channel Pore at Human Cardiac Sodium Channel NaV1.5

Alican Gulsevin, Andrew M Glazer, Tiffany Shields, Brett M Kroncke, Dan M Roden, Jens Meiler

Subject: Biology And Life Sciences, Biophysics Keywords: voltage-gated sodium channels; cardiac sodium channels; SCN5A; veratridine; toxins; molecular docking; Rosetta; electrophysiology; site-directed mutagenesis

Online: 5 January 2022 (18:02:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0022.v1

Potassium at the Origins of Life: Did Biology Emerge From Biotite in Micaceous Clay?

Helen Greenwood Hansma

Subject: Biology And Life Sciences, Biophysics Keywords: clay; mica; biotite; muscovite; origin of life; abiogenesis; mechanical energy; work; wet-dry cycles

Online: 4 January 2022 (20:36:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0500.v1

Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: The Effect of CH1 Domain Deletion

Saeko Yanaka, Shigetaka Nishiguchi, Rina Yogo, Hiroki Watanabe, Jiana Shen, Hirokazu Yagi, Takayuki Uchihashi, and Koichi Kato

Subject: Biology And Life Sciences, Biophysics Keywords: immunoglobulin G; complement component C1; high-speed atomic force microscopy; CH1; CL

Online: 31 December 2021 (10:36:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0488.v5

The Solar System: Nature and Mechanics

Mario Ljubičić

Subject: Biology And Life Sciences, Biophysics Keywords: solar system; complete relativity; nature; mechanics

Online: 27 December 2021 (13:56:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0228.v1

Photodegradation of Lipofuscin in Suspension and in ARPE-19 cells and the Similarity of Fluorescence of the Photodegradation Product with Oxidized Docosahexaenoate

Małgorzata B. Różanowska, Bartosz Różanowski

Subject: Biology And Life Sciences, Biophysics Keywords: lipofuscin; retina; retinal pigment epithelium; docosahexaenoate; docosahexaenoic acid; fluorescence; photodegradation; photobleaching; cell viability; endocytic activity

Online: 14 December 2021 (11:41:14 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0174.v1

The Thermodynamically Expensive Contribution of Three Calcium Sources to Somatic Release of Serotonin

Francisco F. De-Miguel

Subject: Biology And Life Sciences, Biophysics Keywords: Calcium channels; somatic exocytosis; serotonin; extrasynaptic release; leech

Online: 10 December 2021 (12:16:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0406.v1

Study on Dynamics and Cluster Analysis between Carbon-based Nanoparticles and Amino Acids

Wanying Huang, Haihong Jia, JunYan Luo

Subject: Biology And Life Sciences, Biophysics Keywords: CBNs; amino acids; Molecular dynamics

Online: 22 November 2021 (14:22:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0098.v1

Multiscale Mapping of the Salt Marshes Using Sentinel-2, Dove and UAV Imagery in the Bay of Mont-Saint-Michel

Antoine Collin, Dorothée James, Antoine Mury, Mathilde Letard, Thomas Houet, Hélène Gloria, Eric Feunteun

Subject: Biology And Life Sciences, Biophysics Keywords: spatiotemporal analysis; high to ultra high spatial resolution; high to very high temporal resolution; NDVI; NIR; neural network modelling, Bay of Mont-Saint-Michel

Online: 4 November 2021 (09:35:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0455.v1

TNF-α plus IL-1β Induces Opposite Regulation of Hemichannels and Gap Junctions in Mesangial Cells Through a RhoA/ROCK-dependent Pathway

Claudia M. Lucero, Marcelo A. León, Paola Fernández, Juan A. Orellana, Victoria Velarde, Juan C Sáez, Gonzalo I Gómez

Subject: Biology And Life Sciences, Biophysics Keywords: connexin hemichannel; gap junction; oxidative stress; Inflammatory receptors; Fasudil; Y-27632.

Online: 29 October 2021 (13:12:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0443.v1

On the Relationship between Corneal Biomechanics, Macrostructure and Optical Properties

Francisco J. Ávila, Laura Remón, Maria Concepción Marcellán

Subject: Biology And Life Sciences, Biophysics Keywords: Keywords: Corneal Biomechanics; Corneal structure; Corneal Aberrations; Optical Density; Scheimpflug imaging; Ocular Response Analyzer.

Online: 28 October 2021 (15:24:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0403.v1

A Stochastic Binary Model for Regulation of Gene Expression to Investigate Treatment Effects Targeting RKIP

Guilherme Giovanini, Luciana Rodrigues Carvalho Barros, Leonardo dos Reis Gama, Tharcisio Citrangulo Tortelli Junior, Alexandre Ferreira Ramos

Subject: Biology And Life Sciences, Biophysics Keywords: RKIP expression regulation; Stochastic binary regulation of gene expression; Treatment targeting RKIP levels increase; Reduction of heterogeneity of treatment response

Online: 23 September 2021 (11:43:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0390.v1

COVID-19 Diagnosis by 5-second Facial Video Processing Using Vibraimage and Artificial Intelligence

Viktor Minkin, Valery Akimov

Subject: Biology And Life Sciences, Biophysics Keywords: COVID-19; vibraimage; behavioral parameters; diagnosis accuracy; ANN; AI

Online: 22 September 2021 (16:28:12 CEST)

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The Covid-19 pandemic spreads in waves for a year and a half, despite significant worldwide efforts, the development of biochemical diagnostic methods and population vaccination. One of the reasons for the infection spread is the impossibility of early disease detection through biochemical diagnostics, since biochemical processes slowly develop in a body. At the same time, well known that behavioral characteristics of a person, measured based on reflex movements, are capable for inertialess assessment of psychophysiological parameters. Vibraimage technology is the method of head micromovements video processing by inter-frame difference accumulation and converting spatial and temporal characteristics of the inter-frame difference into behavioral and psychophysiological parameters. Here we shown that behavioral parameters measured by vibraimage changed during COVID-19 infection. The identification of changes signs in behavioral parameters detected by AI trained on patients and controls. The best diagnostic accuracy (higher 94%) obtained using instantaneous values of behavioral parameters measured with the following vibraimage settings: 10Hz frequency of basic measurements; 25 inter-frame difference accumulations and averaging the diagnostic results over period of at least 5 seconds. COVID-19 diagnoses by behavioral parameters showed earlier (5-7 days) detection of the disease compared to symptoms and positive results of biochemical RT-PCR testing. Proposed method for COVID-19 diagnosis indicates infected persons within 5 seconds video processing using standard television cameras (web, IP) and computers, allows mass testing/selftesting and will stop the pandemic spread. We assume that head micromovements analysis for diagnosis of various diseases is possible not only with the help of vibraimage technology. Further research of human head micromovement analysis will help stop the COVID-19 pandemic and will contribute to the development of new contactless and environmentally friendly methods for early diagnosis of diseases.

Preprint ARTICLE | doi:10.20944/preprints202109.0333.v1

Computational Insights into the Binding Mechanism of OxyS sRNA with Chaperone Protein Hfq

Mengxin Li, Yalong Cong, Yifei Qi, John Z.H. Zhang

Subject: Biology And Life Sciences, Biophysics Keywords: small RNA Oxys; RNA chaperone Hfq protein; gene expression regulator; molecular dynamics simulations; binding free energy; interaction entropy

Online: 20 September 2021 (12:47:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0488.v4

The Solar System

Mario Ljubičić

Subject: Biology And Life Sciences, Biophysics Keywords: solar system; complete relativity; nature; mechanics

Online: 20 September 2021 (12:13:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0265.v1

p53 Transactivation Domain Mediates Binding and Phase Separation With poly-PR/GR

Sinem Usluer, Emil Spreitzer, Benjamin Bourgeois, Tobias Madl

Subject: Biology And Life Sciences, Biophysics Keywords: poly-PR/GR; neurodegenerative disease; LLPS; p53; intrinsically disordered domains; membraneless organelles

Online: 15 September 2021 (14:43:48 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0101.v1

Insights in the Interaction of HPV-16 E6 and Its Variants (E-G350, E-A176/G350, E-C188/G350, AAa and AAc) with MAGI-1

Lilian Esmeralda Araujo- Arcos, Ciresthel Bello-Rios, Olga Lilia Garibay- Cerdenares, Marco Antonio Leyva-Vázquez, Sarita Montaño, Berenice Illades-Aguiar

Subject: Biology And Life Sciences, Biophysics Keywords: E6; variants; MAGI-1; molecular dynamic simulation; docking

Online: 6 September 2021 (13:51:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202108.0453.v1

Biophysical and Biochemical Attributes of Hybrid Epithelial/Mesenchymal Phenotypes

Subbalakshmi Ayalur Raghu, Bazella Ashraf, Mohit Kumar Jolly

Subject: Biology And Life Sciences, Biophysics Keywords: Hybrid epithelial/mesenchymal phenotypes; Collective cell migration; epithelial-mesenchymal heterogeneity; mathematical modeling; cell-state transition; live-cell imaging

Online: 23 August 2021 (14:32:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0039.v1

Structure and Interdigitation of Chain-Asymmetric Phosphatidylcholines and Milk Sphingomyelin in the Fluid Phase

Moritz PK Frewein, Milka Doktorova, Frederick A Heberle, Haden L Scott, Enrico F Semeraro, Lionel Porcar, Georg Pabst

Subject: Biology And Life Sciences, Biophysics Keywords: Mixed-chain lipids; Neutron scattering; X-ray scattering; MD simulations

Online: 1 July 2021 (22:26:58 CEST)

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Working Paper ARTICLE

A Novel Approach to Understanding the Conscious Self, Will, Behavior, and Psychopathology and Its Treatment

Fredric Schiffer

Subject: Biology And Life Sciences, Biophysics Keywords: consciousness 1; subjective experience 2; will 3; agency 4; self 5; psychopathology 6; treatment 7; transcranial near infrared light 8; biophotomodulation 9

Online: 25 May 2021 (08:44:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0394.v1

Exploring patterns in modularity of protein interaction networks across the tree of life using Spectral Entropy

Anshuman Swain, Jesse Milzman, William F Fagan

Subject: Biology And Life Sciences, Biophysics Keywords: Modularity; Protein-to-protein interaction networks; Spectral characterization; Tree of life

Online: 17 May 2021 (16:56:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0042.v1

RNA Identification and Detection of Nucleic Acids as Aerosols in Air Samples by Means of Photon and Electron Interactions

Luca J Tagliapietra, Piero Neuhold, John I Adlish, Riccardo Surrente

Subject: Biology And Life Sciences, Biophysics Keywords: viral particles; radiobiology; RNA detection; microbiology; matter identification; particle physics; physical modelling; particle accelerators in environmental studies

Online: 10 May 2021 (15:35:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0681.v1

To Know Them, Remove Them: An Outer Methodological Approach to Biophysics and Humanities

Arturo Tozzi

Subject: Biology And Life Sciences, Biophysics Keywords: non-classical logic; Richard Avenarius; Nicholas of Autrecourt; aganglionosis; Paolo and Francesca; Scholastics; Mohammed Ali.

Online: 26 April 2021 (15:12:32 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202104.0606.v1

Role of alpha-Synuclein in Cell Biology: A Hypothesis

Renu Minda

Subject: Biology And Life Sciences, Biophysics Keywords: Parkinson disease; alpha-synuclein; thermodynamics; Carnot cycle; mitochondria

Online: 22 April 2021 (10:47:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0111.v1

Biophysics of Nervous Embryo-Fetal Development

Arturo Tozzi

Subject: Biology And Life Sciences, Biophysics Keywords: soft matter; liquid crystals; braid group; anyon; brain; microcolumn

Online: 2 March 2021 (16:56:14 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0173.v1

At the molecular resolution with MINFLUX?

Kirti Prakash

Subject: Biology And Life Sciences, Biophysics Keywords: MINFLUX, STED, SMLM, localisation precision, image resolution, super-resolution imaging

Online: 8 February 2021 (07:50:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0038.v1

Detection of Chymotrypsin by Optical and Acoustic Methods

Ivan Piovarci, Tibor Hianik, Ilia N. Ivanov

Subject: Biology And Life Sciences, Biophysics Keywords: chymotrypsin; β-casein; nanoparticles; UV-Vis spectroscopy; dynamic light scattering; quartz crystal microbalance.

Online: 1 February 2021 (13:59:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0032.v2

Non-Thermal Millimeter Waves Non-Ionizing Radiation of Saccharomyces Cerevisiae – Insights and Interactions

Ayan Barbara, Shailendra Rajput, Konstantin Komoshvili, Jacob Levitan, Asher Yahalom, Stella Liberman- Aronov

Subject: Biology And Life Sciences, Biophysics Keywords: Non-ionizing Radiation; Millimeter waves; Novel biomedical applications; Yeast; Non-invasive devices

Online: 22 January 2021 (14:31:18 CET)

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Working Paper ARTICLE

Synchronized Oscillations in Double-Helix B-DNA Molecules with Mirror-Symmetric Codons

Enrique Maciá

Subject: Biology And Life Sciences, Biophysics Keywords: double-stranded DNA; DNA dynamical models; correlated oscillations in macromolecules; epigenetic changes

Online: 4 January 2021 (16:35:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0731.v1

Agroclimatic Impact on Gastrointestinal Infection: A Mathematical Model

Goutam Ghosh, Subhasish Bandyopadhyay, Amit Chattopadhyay

Subject: Biology And Life Sciences, Biophysics Keywords: Anthelmintic; EPG; Strongyle; Coccidia; Epidemiology; ODE

Online: 30 November 2020 (14:15:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0199.v1

GENAVOS: A New Tool for Modelling and Analyzing Cancer Gene Regulatory Networks Using Delayed Nonlinear Variable Order Fractional System

Hanif Yaghoobi, Keivan Maghooli, Masoud Asadi-Khiavi, Nader Jafarnia Dabanloo

Subject: Biology And Life Sciences, Biophysics Keywords: Gene Regulatory Networks; Non-Linear Variable Order Fractional System; Gene Expression; Epigenetic Memory

Online: 4 November 2020 (15:35:24 CET)

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Working Paper ARTICLE

Mechanisms of the Non-Thermal Exposure Effects of Non-Ionizing Millimeter Waves Radiation on Eukaryotic Cells for Improving Technological Precision Enabling Novel Biomedical Applications

Ayan Barbara, Shailendra Rajput, Konstantin Komoshvili, Jacob Levitan, Asher Yahalom, Stella Liberman- Aronov

Subject: Biology And Life Sciences, Biophysics Keywords: non-ionizing radiation; millimeter waves; novel biomedical applications; yeast; non-invasive devices

Online: 17 September 2020 (07:08:47 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202009.0343.v1

The Solution of the Cosmological Constant Problem: The Cosmological Constant Exponential Decrease in the Super-Early Universe

Ol'ga Babourova, Boris Frolov

Subject: Biology And Life Sciences, Biophysics Keywords: Poincaré–Weyl gauge theory; super-early Universe; effective cosmological constant

Online: 16 September 2020 (03:27:49 CEST)

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Biology and Life Sciences