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Preprint ARTICLE | doi:10.20944/preprints202207.0447.v1

Impact of COVID-19 Pandemic on School-aged Children’s Physical Activity, Screen Time and Sleep in Hong Kong: a Cross-sectional Repeated Measures Study

Hung-Kwan So, Gilbert T Chua, Ka-Man Yip, Keith TS Tung, Rosa S Wong, Lobo HT Louie, Winnie WY Tso, Ian Wong, Jason Yam, Mike Kwan, Gary KK Lau, Judy Kong, Wilfred HS Wong, Patrick Ip

Subject: Medicine & Pharmacology, Pediatrics Keywords: COVID-19 pandemic; school closures; school-aged children; physical activity; screen time; sleep; Hong Kong

Online: 29 July 2022 (03:57:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0418.v1

Intent among Parents to Vaccinate Children before Pediatric Vaccine Recommendations, Minnesota and Los Angeles County, California--May-September 2021

Kara A. Suvada, Stuart F. Quan, Matthew D. Weaver, Meera Sreedhara, Mark É. Czeisler, Kathy Como-Sabetti, Ruth Lynfield, Prabhu Grounder, Elizabeth Traub, Aryana Amoon, Chandresh Ladva, Mark E. Howard, Charles A. Czeisler, Shantha Rajaratnam, Donatus U. Ekwueme, Brendan Flannery, Rashon I. Lane

Subject: Medicine & Pharmacology, Pediatrics Keywords: COVID-19; vaccination; adolescents; parents; school

Online: 27 July 2022 (10:00:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0384.v1

Clinical and Evolutionary Features of SARS Cov-2 Infection (COVID-19) in Children, A Romanian Perspective

George Jugulete, Daniela Pacurar, Mirela Luminita Pavelescu, Mihaela Safta, Elena Gheorghe, Bianca Borcos, Carmen Pavelescu, Mihaela Oros, Madalina Merisescu

Subject: Medicine & Pharmacology, Pediatrics Keywords: SARS-CoV-2; COVID-19; children; clinical features; comorbidities; male genderSARS-CoV-2, COVID-19, children, clinical features, comorbidities, male gender

Online: 26 July 2022 (04:43:02 CEST)

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Background: Given the potential for additional development to clarify a better knowledge of the overall impact of COVID-19 on the pediatric population, the clinical symptoms of SARS-CoV-2 infection in children and adolescents are still being explored. Morbidity in children is characterized by a variable clinical course. Our study's goal was to compare clinical aspects of 230 pediatric patients who tested positive for SARS-CoV-2 and were hospitalized between April 2020 and March 2022. Methods: In a retrospective analysis, we compared two groups hospitalized in the infectious diseases clinical ward IX at the National Institute for Infectious Diseases "Prof. Dr. Matei Bals," Bucharest, Romania. The first group of 88 patients was admitted between (April–December 2020) and their clinical manifestations were compared with the second group of 142 children followed between July 2021 and March 2022. Results: Of 230 children, the median age was 4.5 (interquartile range 0.6-17) years, 53.9% were male. 88 (36.21%) patients (first group) were admitted during the second wave in Romania, mostly aged < 5 years old, and experienced digestive manifestations like fever (p=0.001), and diarrhoea (p=0.004). The second group experienced different clinical signs when compared with the first group, with higher temperature and increased respiratory symptoms analogous to those of acute respiratory viral infections. The proportion in the second group increased, and 64.5% had symptoms for a median interval of 5 days; age (0-4 -years old) and length of stay were both proportionally inversely (p<0.01) and with correlation with hospital admission (p = 0.04). We report two Paediatric Inflammatory Multisystem Syndrome (PIMS) in the second group, with favourable evolution under treatment. Comorbidities were risk factors for complications appear (p < 0.001) in both groups. All paediatric cases admitted to our clinic evolved favourably and no death was recorded. Conclusions: In the first group children experienced digestive symptoms, whereas the second group experienced mild and moderate respiratory symptoms. We confirmed risk factors for severe cases as manifestations across the age spectrum, 0-4 (digestive symptoms) and 5-12 years old (for respiratory symptoms), associated comorbidities, fever, and male gender. The potential effects of COVID-19 infection in children older than 5 years should encourage caregivers to vaccinate and improve the prognosis among pediatric patients at risk.

Preprint REVIEW | doi:10.20944/preprints202207.0251.v1

Adenovirus Infection in Pediatric Hematopoietic Cell Transplantation: A Challenge Still Open for Survival

Simone Cesaro, Fulvio Porta

Subject: Medicine & Pharmacology, Pediatrics Keywords: adenovirus infection; adenovirus disease; cidofovir; preemptive therapy; risk factors; survival

Online: 18 July 2022 (08:13:46 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202206.0324.v1

Time of Dinner may Contribute to Keep Majorcan Children Free from Otitis

Ruth Diez, Sergio Verd, Jaume Ponce-Taylor, Antonio Gutierrez, Maria Llull, Maria-Isabel Martin-Delgado, Olga Cadevall, Jan Ramakers

Subject: Medicine & Pharmacology, Pediatrics Keywords: circadian clock; otitis media; late dinner; common cold; Mediterranean diet; oxidative stress; chronotype

Online: 23 June 2022 (10:37:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0206.v1

Evaluation of Baseline Characteristics and Prognostic Factors in Multisystemic Inflammatory Syndrome in Children: Is It Possible to Foresee the Prognosis in the First Step?

Benhur Sirvan Cetin, Ayşenur Paç Kısaarslan, Sedanur Tekin, Merve Basol Goksuluk, Ali Baykan, Başak Nur Akyıldız, Yılmaz Seçilmiş, Hakan Poyrazoglu

Subject: Medicine & Pharmacology, Pediatrics Keywords: COVID-19; multisystem inflammatory syndrome in children (MIS-C); risk classification; prognosis

Online: 14 June 2022 (11:12:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0203.v1

Nupur Parakh, Puneet Sahi, Jagdish Chandra

Subject: Medicine & Pharmacology, Pediatrics Keywords: Gilbert Syndrome; Deferiprone; bone deformity

Online: 14 June 2022 (10:18:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0228.v1

Reactogenicity of mRNA and non-mRNA Based COVID-19 Vaccines Among Lactating Mother and Baby Dyads

Beth Jacob-Chow, Vasundhara Kandarpa Lakshmi, Hon Kit Cheang, Le Ye Lee, Jia Ming Low, Amin Zubair

Subject: Medicine & Pharmacology, Pediatrics Keywords: COVID-19 vaccines; SARS-CoV2; lactation; mother-child dyads; reactogenicity

Online: 17 May 2022 (10:31:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0044.v1

The Typology and Topography of Child Abuse and Neglect: The Experience of a Tertiary Children’s Centre

Geoff Debelle, Nikolaos Efstathiou, Rafiyah Khan, Annette Williamson, Manjit Summan, Julie Taylor

Subject: Medicine & Pharmacology, Pediatrics Keywords: child maltreatment; administrative data; domestic violence/abuse; physical abuse; burns; neglect; emotional abuse; poverty

Online: 5 May 2022 (15:47:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0011.v1

Tanning Bed Legislation for Minors: A Comprehensive International Comparison

Katharina Diehl, Karla S. Lindwedel, Sonja Mathes, Tatiana Görig, Olaf Gefeller

Subject: Medicine & Pharmacology, Pediatrics Keywords: tanning bed; sunbed; legislation; ban; adolescent; minors; ultraviolet radiation

Online: 4 May 2022 (13:19:10 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202204.0285.v1

Progressive Respiratory Insufficiency in a Teenager with Diaphragmatic Hypomotility Due to a Novel Combination of Gliomedin Gene Variants

Benjamin Eurich, Catharina Nitsche, Margot Lau, Britta Hanker, Juliane Spiegler, Guido Stichtenoth

Subject: Medicine & Pharmacology, Pediatrics Keywords: GLDN variant; gliomedin; juvenile progressive respiratory insufficiency; diaphragmatic hypomotility; scoliosis; arthrogryposis; LCCS11; axonopathy; FADS

Online: 29 April 2022 (03:36:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0014.v1

Prevalence and Determinants of Excessive Screen Viewing Time in Children and its Effects on Physical Activity, Sleep, Eye Symptoms and Headache

Shilpa Jain, Shreya Shrivastava, Aditya Mathur, Deepali Pathak, Ashish Pathak

Subject: Medicine & Pharmacology, Pediatrics Keywords: screen view time; children; risk factors; India

Online: 4 April 2022 (10:57:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202203.0398.v1

Rubella Virus Research in the Years 2000–2022: A Bibliometric Analysis

Hafiz Zeeshan, Ashina Sadiq, Hina Kirn

Subject: Medicine & Pharmacology, Pediatrics Keywords: bibliometric analysis; Pubmed; rubella virus; research output; research collaboration; Biblioshiny; Bibliometrix; R-package

Online: 31 March 2022 (07:37:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0224.v2

Excessive Use of Paracetamol (Acetaminophen) during Early Development and Difficulties in Retrospective Analyses of Risks

Dillan Bono-Lunn, Maragatha Kuchibhatla, Antara Palkar, Jasmine Cendejas-Hernandez, Joshua T. Sarafian, Victoria G. Lawton, Lauren G. Anderson, John P. Jones III, William Parker

Subject: Medicine & Pharmacology, Pediatrics Keywords: acetaminophen; paracetamol; autism; pediatrics; safety

Online: 30 March 2022 (05:47:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0296.v1

Managing Care during the COVID-19 Pandemic: The Point of View and Fears of Pediatric Cancer Patients’ Families

Olga Nigro, Giovanna Sironi, Andrea Ferrari, Gabriele Tinè, Gabriele Infante, Francesco Barretta, Matteo Silva, Carlo Alfredo Clerici, Stefano Chiaravalli, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Cristina Meazza, Filippo Spreafico, Michela Casanova, Monica Terenziani, Roberto Luksch, Maura Massimino

Subject: Medicine & Pharmacology, Pediatrics Keywords: COVID-19; pediatric cancer; managing care

Online: 23 February 2022 (13:57:46 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202202.0288.v1

A Case of Focal Segmental Glomerulosclerosis in a Young Girl with a Very Low Birth Weight

Yasuyo Kashiwagi, Kazushi Agata, Gaku Yamanaka, Hisashi Kawashima

Subject: Medicine & Pharmacology, Pediatrics Keywords: chronic kidney disease; low birth weight; focal segmental glomerulosclerosis; two-hit theory

Online: 23 February 2022 (08:26:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0358.v1

Which Examination Is Most Useful in Assessing the Phenotype of Left Ventricular Noncompaction Cardiomyopathy in Children – Echocardiography, Cardiovascular Magnetic Resonance, or Both?

Agata Paszkowska, Jędrzej Sarnecki, Alicja Mirecka-Rola, Monika Kowalczyk-Domagala, Łukasz Mazurkiewicz, Lidia Ziółkowska

Subject: Medicine & Pharmacology, Pediatrics Keywords: left ventricular noncompaction; cardiomyopathy; imaging; echocardiography; cardiovascular magnetic resonance; children

Online: 24 January 2022 (13:59:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0285.v1

Comparing Measurement Properties of the English EQ-5D-Y Three-Level Version with the Five-Level Version in South Africa

Janine Verstraete, Razia Amien, Des Scott

Subject: Medicine & Pharmacology, Pediatrics Keywords: Health Related Quality of Life, EQ-5D-Y-3L, EQ-5D-Y-5L, Youth, children, orthopaedic

Online: 20 January 2022 (07:23:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0264.v1

Disease Severity and Risk Factors of 30-Day Hospital Readmission in Pediatric Hospitalizations for Pneumonia

Motomori O. Lewis, Phuong T. Tran, Yushi Huang, Raj A. Desai, Yun Shen, Joshua D Brown

Subject: Medicine & Pharmacology, Pediatrics Keywords: pediatric pneumonia; hospital readmission; healthcare quality; hospital costs

Online: 18 January 2022 (16:08:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints202201.0148.v1

CSF Upward Motion Is Crucial for ETV Success

Hans Ludwig, Steffi Dreha-Kulaczewski, Christoph Bock

Subject: Medicine & Pharmacology, Pediatrics Keywords: Neuroendoscopy; ETV; Hydrocephalus; ETVSS; T2 flow void; Real-time MRI; Inspiration

Online: 11 January 2022 (14:08:02 CET)

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Purpose: ETV is indicated for treating obstructions of major CSF pathways. The outcome evaluation often yields success rates of only +- 70% for shunt independency. Hence, compromised CSF absorption seems to occur more often than expected. We searched for parameters suitable to assess the involved CSF dynamics. Material and Methods: This was a prospective study in 58 paediatric patients (7.7 yrs. mean age) between 2000 and 2020 with aqueductal stenosis (11/58), obstruction of the aqueduct due to tumor growth (22/58),and connatal hydrocephalus (9/58). The average follow-up interval was 4.7 years. Head circumferences, Evans- and fronto-occipital horn ratios before and 3 months after ETV were obtained as Delta-indices. Furthermore ETV success score (ETVSS), the patency of the aqueduct pre- and postoperatively as well as of the stoma were assessed by flow void signs on MRI. Evaluation on MRI also included the shape of the floor of the 3^rd ventricle and whether or not the septum pellucidum showed signs of perforation. Four patients were analysed pre- and postoperatively via real-time MRI. At least the educational status regarding protected or unprotected education was analyzed. Results:The prevalence of a bowing of the floor of the 3^rd ventricle was 72%, and the ETVSS was 71.0%. In 26 children a septal perforations or an open aqueduct prior to ETV (19) could be identified. Mean ER and FOHR were reduced by 0.03 and 0.05 , respectively. Maintained open (flow void on postop MRI) or perforation could successfully be carried out during endoscopic surgery in 44 patients (79%). The disproportionate increase of head circumference abated in 79.4% of patients. New shunt insertion occurred in 16 patients (27.5%). Intraoperatively upward CSF flow was detected in all cases. Statistical analyses(ANOVA) showed significant results for unprotected education, postoperative ER and FOHR but not for open stoma. Conclusion: The identification of flow through the stoma on postoperative MRI seems to be a necessary but not sufficient condition for ETV success. In our study, ventricular volumes were used as parameters to determine success rates as well as unprotected education. Furthermore, enabling upward CSF flow driven by inspiration seems crucial for successful ETV.

Preprint ARTICLE | doi:10.20944/preprints202201.0034.v1

Estimating the Male to Female Ratio in Autistic Spectrum Disorder, Defining and Calculating the Biases and Finding the True Number of Girls.

Robert McCrossin

Subject: Medicine & Pharmacology, Pediatrics Keywords: autistic spectrum disorder, male to female ratio, biases, young women.

Online: 5 January 2022 (10:57:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202201.0017.v1

Inclusion and Withdrawal Criteria for Growth Hormone (GH) Therapy in Children with Idiopathic GH Deficiency—Towards Following the Evidence but Still with Unresolved Problems

Joanna Smyczyńska

Subject: Medicine & Pharmacology, Pediatrics Keywords: short stature; growth hormone deficiency; insulin-like growth factor-1; growth hormone stimulation tests; neurosecretory dysfunction; final height; retesting

Online: 4 January 2022 (18:05:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0516.v1

The Role of the Global Solar UV Index for Sun Protection of Children in German Kindergartens

Olaf Gefeller, Sonja Mathes, Wolfgang Uter, Annette B. Pfahlberg

Subject: Medicine & Pharmacology, Pediatrics Keywords: health attitudes; health knowledge; skin cancer; sun protection; ultraviolet radiation; UV index

Online: 31 December 2021 (11:56:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0407.v1

Decrease in the Use of Parenteral Fluids in Premature Infants from 31 to 34 Weeks of Gestation at Birth

Angela Hoyos, Pablo Vasquez-Hoyos

Subject: Medicine & Pharmacology, Pediatrics Keywords: Parenteral fluids in premature infants; late premature infants; infections associated with the use of lines; early oral feeds

Online: 24 December 2021 (14:43:57 CET)

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Introduction: Some of the practices in medicine are carried out of habit without proven benefits. This is the case of premature babies from 31 to 34 weeks of gestation who are always given parenteral fluids, even though this practice has been associated with an increase incidence of infection. In 2017, we started a protocol of parenteral fluid restriction. To administer nutrition/fluids, we used oral fluids by suction if this was possible or otherwise by oral/nasogastric tube at volumes of 15-20 mL intake every 3 hours, with 5 mL increments every 12-24 hours until 200 mL/K/day was achieved, always using breast milk when possible.Material and methods: The present study sought to compare cases before and after this new policy. For this work, we review all premature babies between 31-34 weeks of gestation discharged home in two periods of time, the first from 01/01/2012 to 12/31/2017 and the second from 01/01/2018 to 08/31/2021. The number of cases with and without parenteral fluids (PF), the incidence of infection, the weight at admission and discharge, and the fall in the weight Z score between birth and discharge were compared. Both the anthropometric and outcome variables were compared using the different statistical methods according to each variable.Results: 725 cases were found with the described characteristics. The groups before and after the intervention did not show significant differences in their general demographic characteristics. A lower use of PF was observed in the second period from 348 cases (79%) to 70 (24%), p <0.001 and fewer days of use (4.1 days/case vs 1.3, p <0.0001) of PF. The weight at discharge and the change in weight Z-score were the same in both groups. Infections went from three cases to zero but it was not statistically significant. There were no complications due to less use of PF.Discussion: This study showed that the use of PF is not associated with significant changes in outcomes of interest, which reinforces that its use does not generate any benefit for the patient. Larger number of cases is required to detect differences in low incidence events such as infections.

Preprint ARTICLE | doi:10.20944/preprints202112.0391.v1

Meta Analysis of Variant Predictions in Congenital Adrenal Hyperplasia Caused by Mutations in CYP21A2

Mayara Jorgens Prado, Rodrigo Ligabue-Braun, Arnaldo Zaha, Maria Lucia Rosa Rossetti, Amit Pandey

Subject: Medicine & Pharmacology, Pediatrics Keywords: online prediction; CYP21A2; mutation analysis; pathogenicity prediction

Online: 23 December 2021 (12:00:40 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0258.v1

Neonatal Intra-Ventricular-Hemorrhage Prevention in Premature at < 30 Weeks Gestational Age

Angela Hoyos, Pablo Vasquez-Hoyos

Subject: Medicine & Pharmacology, Pediatrics Keywords: Intraventricular Hemorrhage; Very preterm infants; Epiclatino registry; Obstetric trauma; Minimal manipulation protocol.

Online: 15 December 2021 (15:05:46 CET)

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Introduction: Intraventricular Hemorrhage (IVH) is a devastating condition mostly in preterm infants at < 30 weeks GA with large morbidities and mortality usually in the first 72 hours after birth. Prevention seems to be the only way to completely deal with this problem. The IVH prevention in this age group has been studied and includes some strategies such as prenatal corticosteroids, cesarean delivery, careful extraction among others, but still, it has an unacceptably high incidence in this population.Objective: To measure the application of a quality improvement project develop from the "Drive to Zero IVH Prevention Project" presented in a Epiclatino lecture in our unit.Material and method: We design a before and after observational study and measured the incidence of IVH before and after October 2017 when a minimum manipulation protocol was implemented at the Clínica del Country (CDC) unit. We also compare these findings to those of other units in the EpicLatino network. All patients born <30 weeks GA with less than 2 days of age, who survived at least 3 days, and had a neuroimaging taken were included. We compared demographics, diagnosis, and frequency of IVH cases, before Nov 2017 and after from CDC and the from 2018-2019 EpicLatino registry using a bivariate analysis. Results: We collected data from 46 cases before, 40 after implementation, and 203 cases from the EpicLatino registry. Demographic characteristics were very similar in the post-intervention with few statistically significant differences in antenatal steroid use (97.5% post, 96% before and 79.3% Epilatino, p=0.016), prolonged rupture of membranes (15% post, 4% before and 15% EpicLatino, p <0.001), vaginal deliveries (7.5% post, 10.9% before and 24.1% Epilatino, p=0.01), suspended chorioamnionitis (12.5% post, 6% before and 20.2% Epiclatino). We found a significant reduction in IVH after the protocol was implemented with only 5 (7.5%) cases post-intervention compared to 19 (29.4%) case before, and when compared to the 81 (39.1%) cases in the registry, p< 0.001. Most of the cases that occurred in the post-intervention occurred before admission to the unit due to obstetric trauma.Discussion: If a well-controlled delivery minimizing obstetric trauma is achieved, a minimal manipulation protocol appears to significantly decrease the incidence of HIV. Controlled, multicenter studies are still required to confirm these findings.

Preprint ARTICLE | doi:10.20944/preprints202112.0257.v1

Early Introduction of Multi-Allergen Mixture for Prevention of Food Allergy

A. Zoe Quake, Taryn Audrey Liu, Rachel D’Souza, Katherine G Jackson, Margie Woch, Afua Tetteh, Vanitha Sampath, Kari C Nadeau, Sayantani Sindher, R. Sharon Chinthrajah, Shu Cao

Subject: Medicine & Pharmacology, Pediatrics Keywords: Multi-allergen; early introduction; food allergy; efficacy; safety; prevention

Online: 15 December 2021 (15:02:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0219.v1

Intragenic Duplication of DMRT1 in a SRY-Negative Boy with 46,XX Disorder of Sex Development

Veronica Bertini, Fulvia Baldinotti, Nina Tyutyusheva, Camillo Rosano, Cinzia Cosini, Adelaide Maria Caligo, Diego Peroni, Angelo Valetto, Silvano Bertelloni

Subject: Medicine & Pharmacology, Pediatrics Keywords: 46,XX disorder of sex development; SRY-negative male; Testis determination; DMRT1; DMRT1 duplication

Online: 14 December 2021 (07:58:55 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0144.v1

Characterization of Mutations Causing CYP21A2 Deficiency in Brazilian and Portuguese Populations

Mayara Jorgens Prado, Shripryia Singh, Rodrigo Ligabue-Braun, Bruna Meneghetti, Thaiane Rispoli, Cristiane Kopacek, Karina Monteiro, Arnaldo Zaha, Maria Rosa Rossetti, Amit V Pandey

Subject: Medicine & Pharmacology, Pediatrics Keywords: 21-hydroxylase deficiency; congenital adrenal hyperplasia; CYP21A2; functional characterization; Cytochrome P450

Online: 9 December 2021 (08:34:16 CET)

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Preprint REVIEW | doi:10.20944/preprints202112.0119.v1

Is Resting State Functional MRI Effective Connectivity in Movement Disorders Helpful? A Focused Review Across Lifespan and Disease

Bethany L. Sussman, Sarah N. Wyckoff, Jennifer Heim, Angus A. Wilfong, David Adelson, Michael C. Kruer, Maria Jose Gonzalez, Varina L. Boerwinkle

Subject: Medicine & Pharmacology, Pediatrics Keywords: resting state functional MRI; effective connectivity; dystonia; movement disorders; subcortical; basal ganglia

Online: 8 December 2021 (11:55:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0093.v1

To Mask or Not to Mask - Evaluation of Cognitive Performance in Children Wearing Face Masks during School Lessons (Maskids)

Anne Schlegtendal, Lynn Eitner, Michael Falkenstein, Anna Hoffmann, Thomas Lücke, Kathrin Sinningen, Folke Brinkmann

Subject: Medicine & Pharmacology, Pediatrics Keywords: children; face masks; school; cognitive impairment; concentration

Online: 6 December 2021 (17:31:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0050.v1

International Approaches to Management of CFTR-Related Metabolic Syndrome / Cystic Fibrosis Screen Positive, Inconclusive Diagnosis

Jane Chudleigh, Jürg Barben, Clement L Ren, Kevin W Southern

Subject: Medicine & Pharmacology, Pediatrics Keywords: cystic fibrosis; newborn bloodspot screening; CFTR-related metabolic syndrome; cystic fibrosis screen positive; inconclusive diagnosis

Online: 3 December 2021 (10:50:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0032.v1

Characterization of Cardiopulmonary Interactions and Exploring Their Prognostic Value in Acute Bronchiolitis: A Prospective Cardiopulmonary Ultrasound Study

Moises Rodriguez-Gonzalez, Patricia Rodriguez-Campoy, Lorena Estepa-Pedregosa, Ana Estalella-Mendoza, Ana Castellano-Martinez, Jose Carlos Flores-Gonzalez

Subject: Medicine & Pharmacology, Pediatrics Keywords: Acute bronchiolitis; Lung ultrasound; Echocardiography; Point of care ultrasonography; Cardi-opulmonary ultrasound; Cardiopulmonary interactions; Pulmonary hypertension; Myocardial strain; NT-proBNP

Online: 2 December 2021 (11:22:02 CET)

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We aimed to delineate cardiopulmonary interactions in acute bronchiolitis and to evaluate the capacity of a combined cardiopulmonary ultrasonography to predict the need for respiratory support. This was a prospective observational single-center study that includes infants < 12 month of age admitted to a hospital due to acute bronchiolitis. All the included patients under-went clinical, laboratory and cardiopulmonary ultrasonographic evaluation at the same time point within 24 hours of hospital admission. The existence of significant correlation between car-diac and respiratory parameters was the primary outcome. The association of different cardio-pulmonary variables with the need of respiratory support higher than O2, the length of stay hos-pitalization, the PICU stay, and the duration of respiratory support were a secondary outcome. We enrolled 112 infants (median age 1 (0.5-3) months; 62% males) hospitalized with acute bron-chiolitis. Increased values of the pulmonary variables (BROSJOD score, pCO2 and LUS) showed moderate correlations with NT-proBNP and all echocardiographic parameters indicative of pulmonary hypertension and myocardial dysfunction. Up to 36 (32%) infants required respira-tory support during the hospitalization. This group presented with higher lung ultrasound score (p<0.001), and increased values of Tei index (p<0.001) and pulmonary artery pressures (p<0.001). All the analyzed respiratory and cardiac variables showed moderate to strong correlations with the LOS hospitalization and the time of respiratory support. Lung ultrasound and echocardiog-raphy showed a moderate to strong predictive accuracy for the need of respiratory support in the ROC analysis, with AUC varying from 0.74 to 0.87. Conclusion: Those cases of bronchiolitis with a worse pulmonary status presented with a more impaired cardiac status. Cardiopulmonary ul-trasonography could be a good strategy to easily identify high-risk population for a complicated acute bronchiolitis hospitalization.

Preprint CASE REPORT | doi:10.20944/preprints202111.0513.v1

Potential Application of Lung Ultrasound in Children with Severe Uncontrolled Asthma: Preliminary Hypothesis Based on a Case Series

Cristina De Rose, Stefano Miceli Sopo, Piero Valentini, Rosa Morello, Daniele Biasucci, Danilo Buonsenso

Subject: Medicine & Pharmacology, Pediatrics Keywords: lung ultrasound; LUS, children; asthma; personalized medicine

Online: 29 November 2021 (07:48:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0461.v1

Passive Microwave Radiometry (MWR) as a Component of Imaging Diagnostics in Juvenile Idiopathic Arthritis (JIA)

Alexander V Tarakanov, Elena S Ladanova, Alexander A Lebedenko, Tatyana D Tarakanova, Sergey G Vesnin, Igor I Goryanin

Subject: Medicine & Pharmacology, Pediatrics Keywords: juvenile idiopathic arthritis; X-Ray; ultrasound; MRI; passive microwave radiometry (MWR).

Online: 24 November 2021 (16:11:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202111.0399.v1

Implementation of Clinical Assistants in a Pediatric Oncology Department: an Activity and Clinical Time Release Analysis

Cristina Adroher, Celia Calvo, Laura Pavon, Ricard Casadevall, Esther Alvarez, Mariona Marsal, Francesc Lopez, Andres Morales La Madrid

Subject: Medicine & Pharmacology, Pediatrics Keywords: clinical assistants; pediatric oncology; assistance activity; new roles; skill mix

Online: 22 November 2021 (14:00:03 CET)

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Background: There is a high bureaucratic and administrative burden associated with health care tasks (test requesting, visits scheduling, supporting documents provision) that has historically largely fallen on health care professionals, which is one among the factors contributing to low job satisfaction and lower productivity. Incorporating new professional roles that help to better respond to the needs of both patients and professionals can increase the quality and efficiency of service provision. Objective: To evaluate the impact of the clinical assistant’s introduction in the Sant Joan de Déu Barcelona Children’s Hospital’s pediatric oncology department, in terms of displacement of activity loads carried out by this new professional role and the consequent time freed up for physicians. Methodology: Observational and retrospective study using administrative data based on the analysis of the type of activity performed by clinical assistants and the measurement of the time freed up in favor of the physicians, based on in situ timekeeping, to approximate the potential skill mix productivity increase. Results: Since its implementation in the pediatric oncology department, clinical assistants have performed 13,553 requests (69.93% of the total), representing a total saving of 266.83 hours or 6.67 workweeks of 40 hours. They performed 74.25% of outpatient surgical requests in the oncology department, 87.5% of day hospital requests and 54.13% of total requests in the outpatient consultations area. Conclusion: The introduction of clinical assistants in the oncology department could be efficient to the extent that it displaces a good part of the bureaucratic and administrative tasks previously performed by health care professionals. This delegation allows them to work more closely to the maximum of their competences and the physicians to have more time for higher added value clinical tasks. In terms of efficiency, this role change enables to optimize the clinical process, reducing the cost by 56% compared to the conventional model.

Preprint ARTICLE | doi:10.20944/preprints202008.0228.v3

Ultra-processed Foods are the Major Sources of Total Fat, Saturated and Trans-fatty Acids Among Tunisian Preschool and School Children: A Cross-sectional Study

Darine Dogui, Radhouene Doggui, Ayoub Aljawaldeh, Jalila El Ati, Myriam El Ati-Hellal

Subject: Medicine & Pharmacology, Pediatrics Keywords: Trans fatty acids; saturated fatty acids; ultra-processed foods; children; Tunisia

Online: 4 November 2021 (11:26:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202110.0241.v1

Spectrum of Clinical Research in Juvenile Idiopathic Arthritis: a Cross-Sectional Analysis of Registered Studies in Clinicaltrials.gov and Clinicaltrialsregister.eu

Ronny Lehmann, Markus Ries

Subject: Medicine & Pharmacology, Pediatrics Keywords: Juvenile idiopathic arthritis, JIA, Research registry, Clinical trial, DMARD

Online: 18 October 2021 (11:00:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0160.v1

Clinical Experience with Anti-IgE Monoclonal Antibody (Omalizumab) In Paediatric Severe Allergic Asthma – A Romanian Perspective

Berghea Elena Camelia, Mihaela Balgradean, Carmen Pavelescu, Catalin Cirstoveanu, Claudia Toma, Marcela Daniela Ionescu, Roxana Silvia Bumbacea

Subject: Medicine & Pharmacology, Pediatrics Keywords: allergic severe asthma; anti-IgE; Omalizumab; observational study; children

Online: 11 October 2021 (13:54:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202110.0094.v1

Geospatial and Social Factors Influencing Morbidity due to Acute Infection in Pediatric Patients in Matiari, Rural Pakistan.

Elise Corden, Saman Hasan Siddiqui, Yash Sharma, Muhammad Faraz Raghib, William Adorno III, Fatima Zulqarnain, Lubaina Ehsan, Aman Shrivastava, Sheraz Ahmed, Fayaz Umrani, Najeeb Rahman, Rafey Ali, Najeeha T. Iqbal, Sean R. Moore, Syed Asad Ali, Sana Syed

Subject: Medicine & Pharmacology, Pediatrics Keywords: nutrition; pediatrics; geographic information systems; acute respiratory infections; diarrhea; growth

Online: 6 October 2021 (09:00:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0355.v1

Neonatal Pneumothorax- Five Years of Experience in a Tertiary Care Center

Miljana Z Jovandaric, Svetlana J Milenkovic, Ivana R Babovic

Subject: Medicine & Pharmacology, Pediatrics Keywords: newborn; therapy; pneumothorax

Online: 21 September 2021 (11:09:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0267.v1

Analysis of Management of Newborns With Critical CHD at Preoperative Stage

Berkin Turkulov, Altyn Aringazina, Kairat Kuatbekov, Vitalii Pak, Ayat Assemov

Subject: Medicine & Pharmacology, Pediatrics Keywords: CHD; newborn; management; organization; cardiac surgery

Online: 15 September 2021 (14:55:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0192.v1

Enzyme Replacement Therapy with Pabinafusp Alfa for Neuronopathic Mucopolysaccharidosis II: an Integrated Analysis of Preclinical and Clinical Data

Roberto Giugliani, Ana Maria Martins, Torayuki Okuyama, Yoshikatsu Eto, Norio Sakai, Kimitoshi Nakamura, Hideto Morimoto, Kohtaro Minami, Tatsuyoshi Yamamoto, Mariko Yamaoka, Toshiaki Ikeda, Sairei So, Kazunori Tanizawa, Hiroyuki Sonoda, Mathias Schmidt, Yuji Sato

Subject: Medicine & Pharmacology, Pediatrics Keywords: neuronopathic mucopolysaccharidosis; Hunter syndrome; mucopolysaccharidosis II; idu-ronate-2-sulfatase; enzyme replacement therapy; neurodegeneration; neurocognitive impairment; pabinafusp afa; blood brain barrier

Online: 10 September 2021 (15:49:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints202109.0103.v1

Keypoints to a Successful Newborn Hearing Screening. Thirty Years of Experience and Innovations

Jose Miguel Sequi Canet, Juan Brines Solanes

Subject: Medicine & Pharmacology, Pediatrics Keywords: Neonatal hearing screening; Otoacoustic emissions; Deafness; Newborn screening.

Online: 6 September 2021 (13:57:57 CEST)

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Working Paper ARTICLE

Male Disadvantage in Oxidative Stress-Associated Complications of Prematurity: A Systematic Review, Meta-analysis and Meta-regression

Elke van Westering-Kroon, Maurice J Huizing, Eduardo Villamor-Martínez, Eduardo Villamor

Subject: Medicine & Pharmacology, Pediatrics Keywords: preterm birth; oxidative stress; sex differences; male disadvantage; female advantage; bronchopulmonary dysplasia; retinopathy of prematurity; necrotizing enterocolitis; intraventricular hemorrhage; periventricular leukomalacia; mortality.

Online: 3 September 2021 (11:08:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0507.v1

Monitored Supplementation of Vitamin D in Preterm Infants: A Randomized Controlled Trial

Alicja Kołodziejczyk-Nowotarska, Renata Bokiniec, Joanna Seliga-Siwecka

Subject: Medicine & Pharmacology, Pediatrics Keywords: vitamin D; osteopenia; prematurity; metabolic bone disease; rickets

Online: 26 August 2021 (11:54:33 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202108.0435.v1

Missed Opportune Children for Immunisation versus Immunisation Defaulters: Why Are They Indistinguishable?

Israel Oluwaseyidayo Idris, Gabriel Omoniyi Ayeni

Subject: Medicine & Pharmacology, Pediatrics Keywords: missed opportunity for immunisation; immunization defaulters; vaccination; World Health Organization; immunization coverage

Online: 23 August 2021 (12:20:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202108.0304.v1

Predictors of Spontaneous Remodelling of Angular Knee Deformities in Children with Healed Nutritional Rickets: A Prospective Cohort Study Protocol

Mostafa M. Baraka, Shady Samir, Shady Mahmoud, Heba Elsedfy, Rana A. Mahmoud, Tamer A. El-Sobky

Subject: Medicine & Pharmacology, Pediatrics Keywords: Child nutrition disorders; Vitamin D deficiency rickets; Metabolic bone diseases; Genu valgum; Genu varum; Bone remodelling.

Online: 13 August 2021 (22:44:42 CEST)

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Background: Nutritional rickets is still considered as a global health problem especially in low-resource countries and immigrant societies of developed countries. Generalized skeletal deformities including angular knee deformities as genu varum and genu valgum are prominent features of nutritional rickets. Angular knee deformities can cause gait difficulties. However, the true remodelling potential of the healed knee deformities is largely unknown to the pediatric and orthopedic community. Aims: The primary objective of this study protocol is to investigate the natural history of disease in regard to the remodelling potential of angular knee deformities in children and adolescents with healed nutritional rickets. And determine the potential patient- and deformity-related factors that are associated with a favorable deformity remodelling as age and sex of patients and type, severity, laterality of deformities etc. Methods: This will be a prospective observational analytical cohort natural history of disease study. A minimum of at least 140 knees with healed nutritional rickets and angular knee deformities will be observed at regular three-monthly intervals over a period of at least one year. We will report two outcome variables namely; clinical and radiological tibio-femoral angle. And independent patient and deformity-related variables as age, sex, deformity type, severity and laterality. Inferential statistics namely bivariate and multivariate analysis will be employed accordingly to identify the relation between outcome variables and the different independent variables. Ethics and dissemination: This protocol study has been approved by the institutional research ethics committee. Results will be presented at conferences and submitted to relevant international and society publications. Authors will also communicate the results to their scholarly networks and post them on scholarly networking sites. Conclusions: This study has the potential for improving the decision-making process as to which patients deserve conservative treatment and which deserve surgical deformity correction. Results are expected to have an impact on the clinical practice of pediatricians, orthopedic surgeons and family physicians alike.

Preprint ARTICLE | doi:10.20944/preprints202107.0434.v1

Clinical and Laboratory Characteristics of Kikuchi-Fujimoto Disease According to Age

Hye-Young Kim, Ha Young Jo, Seong Heon Kim

Subject: Medicine & Pharmacology, Pediatrics Keywords: Kikuchi-Fujimoto disease; histiocytic necrotizing lymphadenitis; prognosis; children; age

Online: 20 July 2021 (09:37:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0184.v1

Nutritional, Gastrointestinal and Endo-Metabolic Traps in the Management of Children with Spinal Muscular Atrophy Type 1

Antonio Corsello, Lorenzo Scatigno, Martina Chiara Pascuzzi, Valeria Calcaterra, Dario Dilillo, Sara Vizzuso, Gloria Pelizzo, Elena Zoia, Anna Mandelli, Annalisa Govoni, Alessandra Bosetti, Ruggiero Francavilla, Flavia Indrio, Valentina Fabiano, Gianvincenzo Zuccotti, Elvira Verduci

Subject: Medicine & Pharmacology, Pediatrics Keywords: SMA; spinal muscular atrophy type 1; SMN1; nutritional management; enteral nutrition; pediatric gastroenterology; dysphagia; neurological disability; endocrine disorders; precocious pubarche

Online: 7 June 2021 (13:14:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0127.v1

Ten years (2011-2021) of the Regional ADHD Centre-Based Network Project for the Diagnosis and Treatment of Children and Adolescents with ADHD

Maurizio Bonati, Francesca Scarpellini, Massimo Cartabia, Michele Zanetti

Subject: Medicine & Pharmacology, Pediatrics Keywords: Attention deficit disorder with hyperactivity; child; adolescent; mental health; chronic disease; register; clinical protocol

Online: 4 June 2021 (09:04:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0043.v1

The Longitudinal Pediatric Data Resource: Facilitating Longitudinal Collection of Health Information to Inform Clinical Care and Guide Newborn Screening Follow-Up Efforts

Amy Brower, Kee Chan, Michael Hartnett, Jennifer Taylor

Subject: Medicine & Pharmacology, Pediatrics Keywords: newborn screening; research; long-term follow-up; NBSTRN; LPDR; RUSP. (3-10 keywords separated by semi colons)

Online: 1 June 2021 (15:10:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202104.0487.v1

Factors Influencing Initiation and Discontinuation of Vitamin D Supplementation Among Infants

Selen HURMUZLU KOZLER, Tulin Revide SAYLI

Subject: Medicine & Pharmacology, Pediatrics Keywords: adherence; healthcare providers; infant; Vitamin D; supplementation

Online: 19 April 2021 (13:25:55 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202104.0187.v2

Brief Report, Rationality and Irrationality in the Use of Antibiotics in the Epiclatino Latin American Neonatal Units

Angela Hoyos

Subject: Medicine & Pharmacology, Pediatrics Keywords: Antibiotic use, Neonatal Units, EpicLatino, Latin America.

Online: 9 April 2021 (13:24:43 CEST)

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Background: Recent years have seen chaos in the neonatology use of antibiotics with diverse opinions and recommendations in international guidelines and societies. This has created great uncertainty in which cases to use, for how long, and which tests apply to make these decisions. We conducted a retrospective cohort study about the use of antibiotics in the EpicLatino neonatal units and a Latin American network database, after noting these variations in the 2019 report. Methods: For the year 2019 using the EpicLatino database, we included cases (only first admission) ≤32 weeks gestational age at birth, excluding one unit that did not accept to participate. The number of cases and days receiving antibiotics were recorded as well as the progression for each unit. Inappropriate use of antibiotics was defined as greater than 3 days in patients with negative cultures (blood/CSF cultures) excluding: major malformations, urinary tract infections, necrotizing enterocolitis (NEC) and cases with suspected chorioamnionitis in the mother (the latter two only during the course of diagnosis of NEC or chorioamnionitis). This study was approved by the EpicLatino board of directors and by the participating units. Results: A total of 6,543 days of antibiotics were observed, 49.5% of cases had at least one positive blood/CSF culture. A total of595 days of antibiotics without justification were found in 72 courses in 61 cases; 14/72(19.4%) had no diagnosis of infection in the database, 7/72(9.7%) did not document any culture throughout their stay, and 37/72(51,4%) obtained only one blood/CSF culture during their entire stay. Most diagnosis were clinical sepsis and in 24/58(41%) curses, a diagnosis of pneumonia with a poor positive culture correlation was found. Furthermore, 74% of the units didn´t use pneumonia as a justification to use antibiotics. Other diagnosis found: Conjunctivitis, NEC 1A and rotavirus NEC. Conclusions: Although the method of reviewing the use of antibiotics in a database has a number of limitations, especially the cause that motivated the use of antibiotics and other tools used for diagnosis of infections, the notable differences between units is striking. Although it is difficult to make recommendations to all units, it is important to control infections in some units and in others to reduce the excessive use of antibiotics, especially with diagnosis of pneumonia in neonates and negative blood/CSF cultures.

Preprint ARTICLE | doi:10.20944/preprints202005.0305.v2

Improvement of Sickle Cell Disease Morbi-Mortality in Children: Experience Gained in a Remote Area of an African Country

Benoît Mukinayi Mbiya, Didier Kalenda Kalombo, Yannick Nkesu Mukendi, Valery Daubie, John Kalenda Mpoyi, Parola Mukendi Biboyi, Ghislain Tumba Disashi, Béatrice Gulbis

Subject: Medicine & Pharmacology, Pediatrics Keywords: sickle cell disease; feasibility; regular follow-up; remote area; Democratic Republic of Congo

Online: 22 September 2020 (08:12:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0435.v1

Pediatric Inflammatory Multisystem Syndrome (PIMS) Did Occur in Poland during Months with Low COVID-19 Prevalence. Preliminary Results of a Nationwide Register.

Magdalena Okarska-Napierała, Kamila Ludwikowska, Leszek Szenborn, Natalia Dudek, Anna Mania, Piotr Buda, Janusz Książyk, Katarzyna Mazur-Malewska, Magdalena Figlerowicz, Maciej Szczukocki, Beata Kucińska, Bożena Werner, Lidia Stopyra, Agnieszka Czech, Elżbieta Berdej-Szczot, Aneta Gawlik, Paulina Opalińska, Artur Mazur, Danuta Januszkiewicz-Lewandowska, Cezary Niszczota, Teresa Jackowska, Jacek Wysocki, Paweł Tracewski, Jacek Kusa, Paulina Potocka, Artur Sulik, Katarzyna Ziora, Helena Krakowczyk, Aleksandra Wodniak, Janusz Zaryczański, Alicja Żakiewicz-Cepak, Elżbieta Jarocka-Cyrta, Agnieszka Koczwara, Anna Prusek-Dudkiewicz, Ewa Zbucka-Jachowska, Sabina Langer-Wójcik, Elżbieta Kołodziej, Ernest Kuchar

Subject: Medicine & Pharmacology, Pediatrics Keywords: PIMS; MIS-C; SARS-CoV-2; COVID-19; Kawasaki disease; survey

Online: 18 September 2020 (11:29:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0330.v1

Parental Reported Bullying among Saudi Schoolchildren: Its Forms, Effect on Academic Abilities, and Associated Sociodemographic, Physical, and Dentofacial Features

Raghad Alabdulrazaq, Sanaa Al-Haj Ali

Subject: Medicine & Pharmacology, Pediatrics Keywords: bullying; dentofacial features; physical features; schoolchildren

Online: 15 September 2020 (04:48:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0073.v1

Genetics and Genomics of Pediatric Pulmonary Arterial Hypertension

Carrie L. Welch, Wendy K. Chung

Subject: Medicine & Pharmacology, Pediatrics Keywords: genomics; pediatrics; lung disease; pulmonary arterial hypertension

Online: 3 September 2020 (15:29:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0452.v1

How Do We Monitor Oxygenation During The Management of PPHN? Alveolar, Arterial or Mixed Oxygen Tension or Peripheral Saturation?

Praveen Chandrasekharan, Munmun Rawat, Satyan Lakshminrusimha

Subject: Medicine & Pharmacology, Pediatrics Keywords: oxygenation; PPHN; oxygen tension

Online: 20 August 2020 (09:50:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0366.v1

The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?

Melissa Rioux, Mara McNeil, Magen Francis, Nicholas Dawe, Mary Foley, Joanne Langley, Alyson Kelvin

Subject: Medicine & Pharmacology, Pediatrics Keywords: vaccine; age; pneumonia; influenza virus; seasonal influenza; influenza imprinting; infant; infant immunity; immune response

Online: 17 August 2020 (12:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0180.v1

Long-Term Effects of Kasai Portoenterostomy for Biliary Atresia

Anna Degtyareva, Alexander Razumovskiy, Nadezhda Kulikova, Sergey Ratnikov, Elena Filippova, Ekaterina Gordeeva, Marina Albegova, Denis Rebrikov, Anna Puchkova

Subject: Medicine & Pharmacology, Pediatrics Keywords: biliary atresia; Kasai portoenterostomy; cholangitis; portal hypertension; bile ducts dilatations; native liver survival

Online: 7 August 2020 (09:27:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0165.v1

A Novel Oral Syringe for Dosing and Administration of Multiparticulate Formulations: Acceptability Study in Preschool and School Children

Justyna Hofmanová, Joanne Bennett, Alastair Coupe, Jeremy Bartlett, Andrew Monahan, Hannah Katharine Batchelor

Subject: Medicine & Pharmacology, Pediatrics Keywords: multiparticulates, administration device, acceptability, paediatric formulation, mouthfeel, oral syringe

Online: 6 August 2020 (12:00:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0008.v1

Normal Percentiles for Respiratory Rate in Children – Reference Ranges Determined from an Optical Sensor

Anthony Herbert, John Pearn, Stephen Wilson

Subject: Medicine & Pharmacology, Pediatrics Keywords: Respiratory Rate; Growth

Online: 2 August 2020 (10:38:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0718.v1

Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children

D M Kamrul Hasan, Shafayat Hossain Evan, Md Rezaul Karim, Xin Yi Men, Zhang Huifeng, Chen Yuan

Subject: Medicine & Pharmacology, Pediatrics Keywords: Sepsis, Septic shock, Lactic acid, Dynamic monitoring, Prognosis

Online: 30 July 2020 (11:23:48 CEST)

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Objectives: To investigate the value of early lactate dynamic monitoring index in predicting prognosis of patients with sepsis and septic shock. Methods: We performed our test on 50 patients. Out of 50 patients, 28 are male, and 22 are female. Prospectively studied pediatric patients with septic shock were performed. Vital signs, Lactate clearance, were obtained at presentation 6 h, 12 h, 24 h over the first 48 h of hospitalization. The therapy received, outcome parameters of mortality and duration of hospitalization were recorded. Results: The statistical data and comparative analysis showed that an average of 16.88 days after admission, 5 patients have died, 17 patients are poorly prognosis leaves the hospital, and the remaining 28 are recovered and discharged. The primary outcome variable of mean 16 days hospitalization mortality rate was 10%. Poor prognosis 34% and fully recovery 56 % were observed. In this retrospective cohort study, a lactate level of more than 2.5mmol/L was the best threshold to predict 28-day mortality among severe sepsis and septic shock patients. In our research, we found mean LC 6 h 3.08mmol/L, and after 48 h mean it is 1.79mmol/L. Significant LC 6 h found, which is 8.08mmol/L in the death group patient where 48 h mmol/L shows significant high. Poor prognosis also presents a clinical increase of lactate level high in the LC 6 h analysis, which is 3.32mmol/L. Recovered patients showed a significant improvement after administering treatment depending on the patient organ involvement and good decrease of lactate reports achieved, which is 1.20mmol/L, where admission reports show it was 1.91mmol/L in LC 6 h. Mean Heart rate 94/51mmhg, pulse 119, temperature 39℃, respiratory rate 32.26, and urine output 456 ml recorded during our study. Death patient shows a remarkable detonation of those reports but has a significant clinical report with the recovered patients. Conclusion: The early lactate dynamic monitoring index has a high value in predicting sepsis and septic shock patients' prognosis, thus worth popularizing.

Preprint BRIEF REPORT | doi:10.20944/preprints202007.0633.v1

Community-Based Household Survey to Identify Disability Burden and Health-Related Quality of Life Following Road Traffic Accidents in Ujjain, India

Aditya Mathur, Love Mehra, Ashish Pathak

Subject: Medicine & Pharmacology, Pediatrics Keywords: Children; adolescents; post-road traffic accidents; EQ-5D-5L; disability burden; health-related quality of life

Online: 26 July 2020 (03:11:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0627.v1

Red Blood Cell Exchange in children with Sickle Cell Disease in French Guiana

Narcisse Elenga, Vincent Vantilcke, Elise Martin, Emma Cuadro, Mickael Parisot, Françoise Maire, Pierre Selles, Thierry Basset

Subject: Medicine & Pharmacology, Pediatrics Keywords: Erythrocytapheresis; red blood cell exchange; sickle cell disease; target HbS level; heparin locking

Online: 26 July 2020 (02:22:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0368.v1

Application of Low-Intensity Modified Constraint-Induced Movement Therapy to Improve the Affecter Upper Limb Functionality in Infantile Hemiplegia with Moderate Manual Ability. Case Series

Rocío Palomo-Carrión, Rita-Pilar Romero-Galisteo, Elena Piñero-Pinto, Purificación López-Muñoz, Helena Romay-Barrero, Francisco García-Muro

Subject: Medicine & Pharmacology, Pediatrics Keywords: family; infantile hemiplegia; modified Constraint-Induced Movement Therapy; Physical Therapy modalities; upper extremity.

Online: 17 July 2020 (08:04:27 CEST)

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Working Paper ARTICLE

Psychosocial Aspects of Children and Adolescents Deliberate Physical Suicide Attempts

Odeta Kinciniene, Rokas Sambaras, Auge Lesinskaite, Virginija Zilinskaite, Sigita Lesinskiene

Subject: Medicine & Pharmacology, Pediatrics Keywords: physical suicide attempt; self-harm; health condition; bullying; violence; adolescent

Online: 14 July 2020 (11:34:21 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202007.0219.v1

Linezolid Add-On Rescue Therapy Cured MRSA Necrotizing Pneumonia: A Case Report in a Preterm Infant

Abbas Moosa Al-Omran, Sameer Yaseen Al-Abdi, Hasan Mohammad Al-Amer

Subject: Medicine & Pharmacology, Pediatrics Keywords: Preterm infant; Necrotizing pneumonia; Methicillin-Resistant Staphylococcus Aureus (MRSA); Pneumatoceles; Linezolid; Vancomycin; Rifampicin

Online: 11 July 2020 (02:10:45 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202006.0118.v1

Infliximab Attenuates Paediatric Inflammatory Multisystem Syndrome in SARS-CoV-2 (PIMS-TS)

Joseph Meredith, Cher-Antonia Khedim, Paul Henderson, David C. Wilson, Richard K. Russell

Subject: Medicine & Pharmacology, Pediatrics Keywords: paediatric; immunology; infectious disease; gastroenterology

Online: 9 June 2020 (05:11:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0020.v1

Timing of Complementary Feeding in Preterm Infants is not Associated with Early Adiposity Rebound: Longitudinal Analysis of BMI Data from Birth to 7 Years

Maria Elisabetta Baldassarre, Antonio Di Mauro, Margherita Caroli, Federico Schettini, Valentina Rizzo, Alessia De Giorgi, Margherita Fanelli, Nicola Laforgia

Subject: Medicine & Pharmacology, Pediatrics Keywords: Adiposity rebound; Infant; Premature; Pediatric Obesity; Complementary Feeding; Weaning; Body Mass Index

Online: 4 June 2020 (03:24:10 CEST)

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Background: Adiposity rebound (AR) refers to the second rise of the BMI curve that usually occurs physiologically between 5 and 7 years of age. AR timing has a great impact on children´s health, being the early adiposity rebound (EAR) associated with the development of metabolic disease later in life. Aim: We aimed to investigate the prevalence of EAR in a cohort of preterm newborns. Secondary outcomes evaluated if some determinants such as (1) gender (male/female), (2) type of delivery (caesarean/vaginal), (3) birth weight (SGA/NGA/LGA), (4) type of feeding (5) duration of breastfeeding, (6) timing of introduction of solid food, (7) parental education and (8) parental pre-pregnancy BMI can influence EAR in this cohort. Tertiary aim was to evaluate the prevalence of obesity or overweight at 7 years of age in children according to early versus timely AR. Methods: This is a perspective, population-based longitudinal study, where infants born preterm were evaluated at birth and at 1, 3, 6, 9, 12, 15, 18, 24 months and 3, 4, 5, 6, 7 years of gestational-corrected age. Weight and height data were analyzed, and BMI was calculated. AR was assessed in the growth trajectory in a body mass index (BMI) plot. Results: Of the 250 preterm newborns included, 100 completed the 7 years follow-up and entered in the final analysis. The prevalence of EAR in our cohort of preterm newborns was 54%. EAR was associated with being LGA at birth. No other factors were associated to EAR. Early adiposity rebounders have a significant higher BMI at 7 years compared to children with timely AR (17.2 ±2.7 vs 15.6 ± 2.05, p=0.021). No significant differences were found in the prevalence of obesity or overweight at 7 years of age in children with early or timely AR (29% vs 14% p=0.202). Conclusions: Clinical management of preterm infants should focus on reducing excess weight gain to prevent long-term metabolic risk. Others neonatal factors are not associated to an higher risk of EAR.

Preprint BRIEF REPORT | doi:10.20944/preprints202005.0482.v1

Neonatal COVID 19 Pneumonia: Report of the First Case in a Preterm Neonate in Mayotte, an Overseas Department of France

Soumeth Abasse, Leila Essabar, Tereza Costin, Voninavoko Mahistra, Mohamed Kaci, Axelle Braconnier, Roger Serhal, Louis Collet, Abdallah Fayssoil

Subject: Medicine & Pharmacology, Pediatrics Keywords: COVID19; preterm neonate; pneumonia; vertical transmission

Online: 31 May 2020 (16:39:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0305.v1

Feasibility and Applicability of Standardized and Regular Follow-up of Sickle Cell Patients in a Remote Area of a Developing Country

Benoît Mukinayi Mbiya, Didier Kalenda Kalombo, Yannick Nkesu Mukendi, Valery Daubie, John Kalenda Mpoyi, Parola Mukendi Biboyi, Ghislain Tumba Disashi, Béatrice Gulbis

Subject: Medicine & Pharmacology, Pediatrics Keywords: sickle cell disease; feasibility; regular follow-up; remote area; Democratic Republic of Congo

Online: 18 May 2020 (17:26:04 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0225.v2

COVID-19: Considerations for Children and Adolescents with Diabetes

Devi Dayal

Subject: Medicine & Pharmacology, Pediatrics Keywords: Coronavirus disease 2019; COVID-19; children; diabetes; type 1 diabetes; type 2 diabetes; recommendations

Online: 15 May 2020 (04:54:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0156.v2

Delays in Initial Referral, Diagnosis and Treatment in Children with Cancer

Abbasali Hosein Pourfeizi, Rana Hosseini, Roghayeh Sheervalilou, Sahar Mehranfar

Subject: Medicine & Pharmacology, Pediatrics Keywords: cancer; delay in referral; children; delay in diagnosis; delay in treatment

Online: 10 May 2020 (18:21:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0160.v1

COVID-19 and Kawasaki Like Disease: The Known-Known, the Unknown-Known and the Unknown-Unknown

Aurélie Morand, Diego Urbina, Alexandre Fabre

Subject: Medicine & Pharmacology, Pediatrics Keywords: Sars-Cov2; Covid-19; Children; Kawasaki disease; toxic shock syndrome

Online: 9 May 2020 (09:01:24 CEST)

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In the end of April nearly 100 cases of children aged between 6 month and 9 years with Kawasaki like disease were reported (mostly in Europe) probably linked to COVID-19. With the increasing awareness of this condition the number of cases reported is increasing worldwide. We aim to sum up the known data about this new entity based on published data (in a case report, a series of 8 cases and in newspapers and society statement) and using our knowledge of classical Kawasaki disease. It seems to be a post infectious disease with an onset between 2-4 weeks after the infection, probably in genetically predisposed children aged between 6 month to 17 years. A very rough estimation of incidence based on current data from Bergamo, Italy, and New York State and a lot assumption is between 0.016% (95% CI:0.013-0.02%) - 0.31% (95% CI: 0.2-0.47%) of infected children. Clinical signs overlaps with Kawasaki disease in some children, but another feature is prominent gastrointestinal manifestations. For the 9 detailed patients most had incomplete presentation for Kawasaki disease (with a mean 1.7 (+/-1.2) criteria per patient for the 5 non fever criterion) and only one had a classical form. In some cases, presentation is closer to toxic shock syndrome or isolated myocarditis. Persistent fever seems to be constant and biological exploration are consistent with inflammation (elevated CRP, ferritin and D-Dimers). Management is described as supportive and children seem to improve rapidly, but can require cardiac or respiratory support. In date of 11 may 2020 there is 4 deaths confirmed linked to these new entities (1 in UK and 3 in New York). Paediatricians and general practitioners need to be aware of these possible evolution following COVID-19 infection. However it seems to be rare and children are probably still spared from most morbidities and mortality linked to COVID-19 infection .There are need of published detailed cohorts to better delineate these entities.

Preprint ARTICLE | doi:10.20944/preprints202004.0404.v1

Analysis of the Human Breast Milk Microbiome and Bacterial Extracellular Vesicles in Healthy Mothers

Su Yeong Kim, Dae Yong Yi

Subject: Medicine & Pharmacology, Pediatrics Keywords: milk; human; microbiota; microbiome; extracellular vesicle; breastfeeding

Online: 23 April 2020 (05:11:19 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0225.v1

COVID-19: Considerations for Children and Adolescents with Diabetes

Devi Dayal

Subject: Medicine & Pharmacology, Pediatrics Keywords: Coronavirus disease 2019; COVID-19; children; diabetes; type 1 diabetes; type 2 diabetes; recommendations

Online: 14 April 2020 (15:21:52 CEST)

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Working Paper ARTICLE

The Shape of Anterior-Posterior Spinal Curvatures and Body Composition in School-Children

Jacek Wilczyński, Magdalena Lipińska-Stańczak

Subject: Medicine & Pharmacology, Pediatrics Keywords: body posture defects; the shape of anterior-posterior spinal curvatures; body composition; school-children

Online: 11 April 2020 (05:38:01 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202004.0043.v1

Maternal Fasting or Fluid Abstention Does Not Significantly Affect the Macronutrient Composition of Human Milk: Clinical and Clinical Research Relevance

Karel Allegaert, anne smits

Subject: Medicine & Pharmacology, Pediatrics Keywords: lactation; physiology-based lactation models; drug exposure prediction; fasting; drug safety; newborn; infant; human milk

Online: 6 April 2020 (09:11:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0352.v1

Maternal Subpopulation Variances in Vaginal and Cesarean Section Delivery Method Predicts Excess Infant Mortality of Black/African Americans in the United States: Linked Birth/Infant Death Records, 2007-2016

Laurens Holmes. Jr, Leah O’Neill, Hikma Elmi, Camillia Comeaux, Chinaka Chinacherem, Lavisha Pelaez, Kirk W. Dabney, Olumuyiwa Akinola, Michael Enwere

Subject: Medicine & Pharmacology, Pediatrics Keywords: vaginal; cesarean section; African American women; infant mortality; race/ethnicity

Online: 23 March 2020 (11:21:46 CET)

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Objective: Racial/ethnic disparities in infant mortality (IM) continue to persist in the United States, with Black/African Americans (AA) being disproportionally affected with threefold increase in mortality compared to Whites. Epidemiologic data have identified maternal characteristics as risk IM such as eclampsia, maternal education, smoking, maternal weight, maternal SES, and family structure. Understanding the cause of causes including the method of labor and delivery and the racial heterogeneity may facilitate intervention mapping in narrowing the Black White IM risk differences. We aimed to assess the temporal/racial trends and the methods of delivery, mainly vaginal versus cesarean section (C-section) as exposure function of IM. Methods: The United States linked Birth/Infant Death records (2007-2016) were used with a cross-sectional ecologic design. The analysis involved chi squared statistic, incidence rate estimation, and period percent change. Results: Of the 40,445,070 births between 2007 and 2016, cumulative mortality incidence was 249,135 (1.16 per 1000). The IM rate was highest among Black/AA (11.41 per 1000), intermediate among Whites (5.19 per 1000), and lowest among Asian /Pacific Islanders (4.24 per 1000). The cumulative incidence rate difference, comparing vaginal to cesarean procedure was 1.73 per 1000 infants, implying excess IM with C-section. Compared to C-section, there was a 31% decreased risk of IM among mothers with vaginal delivery, rate ratio (RR) = 0.69, 95% CI 0.64-0.74. Racial disparities was observed in the method of delivery associated with IM. Black/AA mothers with vaginal delivery had a 6% decreased risk of IM compared to C-section, RR = 0.94, 95%CI 0.92-0.95, while Whites with vaginal delivery had a 38% decrease risk of IM relative to C-section, RR= 0.68, 95%CI 0.67-0.69, p<0.001. Conclusion: Infant mortality varied by race, with Black/AA disproportionally affected which is explained in part by labor and delivery procedures, suggesting reliable and equitable intrapartum assessment of Black/AA mothers during labor.

Preprint ARTICLE | doi:10.20944/preprints202002.0356.v1

CCHD Screening Implementation Efforts in Latin American Countries by the Ibero American Society of Neonatology (SIBEN)

Augusto Sola, Susana Rodriguez, Alejandro Young, Lourdes Lemus, Ramon Mir Villamayor, Marcelo Cardetti, Jorge Pleitez Navarrete, Veronica Favareto, Victoria Lima, Hernando Baquero, Lorena Velandia Forero, Maria Elena Venegas, Carmen Davila, Fernando Dominguez Dieppa, Taina Malena Germosen, Ada Nidia Oviedo Barrantes, Ana Lorena Alvarez Castañeda, Monica Morgues, Aldana Avila, Diana Fariña, Jose Luis Oliva, Erika Sosa, Sergio G Golombek

Subject: Medicine & Pharmacology, Pediatrics Keywords: pulse oximetry; congenital heart disease; neonate; hypoxemia; Latin America; Ibero-American Society of Neonatology

Online: 24 February 2020 (14:08:22 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202002.0252.v1

Thrombocytosis in an Infant with a TRPV4 Mutation: A Case Report

Christopher S. Thom, Erik Brandsma, Michele P. Lambert

Subject: Medicine & Pharmacology, Pediatrics Keywords: thrombocytosis; skeletal dysplasia; TRPV4; calcium channel

Online: 18 February 2020 (02:47:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202002.0154.v1

Examination of Demographic Characteristics of Drug and Corrosive Poisonings, Morbidity and Mortality in Children in terms of Emergency Department and Pediatric Surgery

Cengiz Güney, Abuzer Coskun

Subject: Medicine & Pharmacology, Pediatrics Keywords: pediatric drug poisoning; emergency department; corrosive; mortality

Online: 11 February 2020 (15:57:47 CET)

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Background: Poisoning constitutes an important part of morbidity and mortality among environmental emergencies that can be prevented, frequent in childhood, requiring rapid diagnosis and treatment. This study aimed was to examine the epidemiological, clinical and therapeutic characteristics of drug and corrosive poisonings in terms of children. Materials and Methods: Between January 2010 and December 2018, 1678 patients between the ages of 1-16 who applied to the emergency department with drug and corrosive poisoning were included in the study. The patients were divided into three groups as 1-5, 6-11 and over 12 years of age, and the substances with known pharmacological agents were divided into 10 groups. The Zargar Classification (7) was used to determine the degree of damage caused by corrosive substances in the esophagus. Results: The mean age of the patients was 8.32 ± 3.23 years (1-15 years). The girl/boy ratio of the cases was 1.18 / 1 and 54.3% were girls. 18.9% of the cases were under five years of age, 61% were between 6-11 years and 20% were older than 12 years. 94.6% of the patients were poisoned by drugs and 5.4% of them were poisoned due to non-drug reasons. Accidental poisoning was most commonly seen in children aged 6-11 and suicides were seen in children older than 12 years. It was found that 62.2% of the poisonings were accidental and 37.8% were suicidal. The most common causes of poisoning were analgesics and paracetamol exposure as a pharmacological agent. Mortality was found to be most common in 1-5 years age group and accidental poisonings. Accidental poisoning was common in girls and suicidal poisoning was common in boys. Grade 3 damage was found endoscopically in all of the mortalities due to corrosive substances. Conclusion: It was found that accidental poisoning was observed in children under five years of age, suicides were observed in children older than 12 years and the most important cause of mortality was due to corrosive substances. Cause-specific rapid diagnosis and treatment will contribute to the reduction of morbidity and mortality.

Preprint REVIEW | doi:10.20944/preprints202001.0315.v1

Succinic Semialdehyde Dehydrogenase Deficiency: An Update

Miroslava Didiášová, Antje Banning, Heiko Brennenstuhl, Sabine Jung-Klawitter, Claudio Cinquemani, Thomas Opladen, Ritva Tikkanen

Subject: Medicine & Pharmacology, Pediatrics Keywords: succinic semialdehyde dehydrogenase deficiency; gamma-amino butyric acid; organic acidurias; enzyme replacement therapy; pharmacological chaperones; clinical trials; autophagy

Online: 26 January 2020 (08:10:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0213.v1

Glomerular Filtration Rate in Former Extreme Low Birth Weight Infants over the Full Pediatric Age Range: A Pooled Analysis

Elise Goetschalkx, Djalila Mekahli, Elena Levtchenko, Karel Allegaert

Subject: Medicine & Pharmacology, Pediatrics Keywords: glomerular filtration rate; Brenner hypothesis; extreme low birth weight infants; renal outcome

Online: 19 January 2020 (05:12:19 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0205.v2

Incidence and Risk Factors for Severe Dehydration in Hospitalized Children in Ujjain, India

Abhishek Sharma, Aditya Mathur, Cecilia Stålsby Lundborg, Ashish Pathak

Subject: Medicine & Pharmacology, Pediatrics Keywords: diarrhoea; severity; severe dehydration; children; risk factors; Ujjain; India

Online: 16 January 2020 (03:21:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0356.v1

Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients

Hasan Smesam, Hasan Qazmooz, Sareh Arjmand, Hussein Kadhem Al-Hakeim, Seyed Omid Ranaei‐Siadat,

Subject: Medicine & Pharmacology, Pediatrics Keywords: Beta-thalassemia, Erythroferrone, Ferritin, Hepcidin, Iron overload

Online: 26 December 2019 (12:37:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0205.v1

Incidence Risk Factors for Severe Dehydration in Hospitalized Children in Ujjain, India

Abhishek Sharma, Aditya Mathur, Cecilia Stålsby Lundborg, Ashish Pathak

Subject: Medicine & Pharmacology, Pediatrics Keywords: diarrhoea; severity; severe dehydration; children; risk factors; Ujjain; India

Online: 16 December 2019 (05:14:30 CET)

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Preprint REVIEW | doi:10.20944/preprints201910.0179.v1

New Insights of Human Parvovirus B19 in Modulating Erythroid Progenitor Cells Differentiation

Shuwen Feng, Dongxin Zeng, Junwen Zheng, Dongchi Zhao

Subject: Medicine & Pharmacology, Pediatrics Keywords: human parvovirus B19; nonstructural protein NS1; erythroid progenitor cells; differentiation; GATA; anemia

Online: 16 October 2019 (05:37:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0314.v1

Demographic, Laboratory and Clinical Comparison of Pediatric Brucella Cases with and without Liver Involvement

Mehmet Agin, Yusuf Kayar

Subject: Medicine & Pharmacology, Pediatrics Keywords: brucellosis; elevated liver enzymes; hepatomegaly; children

Online: 29 August 2019 (17:22:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0170.v1

The Associations of Physical Activity and Sedentary Behaviour with Mental Health in a Nationwide Sample of Kazakhstan Adolescents

Kwok Ng, Alina Cosma, Shynar Abdrakhmanova, Assel Adayeva

Subject: Medicine & Pharmacology, Pediatrics Keywords: WHO-5; well-being; rural; urban

Online: 15 August 2019 (16:17:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0101.v1

Bezafibrate Improves Mitochondrial Fission and Function in DNM1L Deficient Patient Cells

Liza Douiev, Ruth Sheffer, Gabriella Horvath, Ann Saada

Subject: Medicine & Pharmacology, Pediatrics Keywords: DNM1L; Drp1; mitochondrial disease; mitochondrial fission-fusion; Bezafibrate; fibroblast

Online: 8 August 2019 (11:01:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0055.v1

Can Fetuin-A Level, CRP, and WBC be a Predictive Value in the Diagnosis of Acute Appendicitis in Children with Abdominal Pain?

Abuzer Coskun, Cengiz Güney

Subject: Medicine & Pharmacology, Pediatrics Keywords: emergency department; pediatric acute appendicitis; perforatio; fetuin-A level

Online: 5 August 2019 (08:00:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0343.v1

A Fifteen Year Analysis of Rare Isolated Fallopian Tube Torsions in Adolescent Children: A Case Series

Cengiz Güney, Abuzer Coskun

Subject: Medicine & Pharmacology, Pediatrics Keywords: emergency department acute abdominal pain; isolated fallopian tube torsion; detorsion; salpingectomy

Online: 31 July 2019 (04:20:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0210.v1

Pertussis Immunisation in Pregnancy Safety (PIPS) Study: A Retrospective Cohort Study of Safety Outcomes in Infants Exposed to Tdap Vaccine in Utero

Helen A. Petousis-Harris, Yannan Jiang, Lennox Yu, Donna Watson, Tony Walls, Nikki Turner, Anna Howe, Jennifer Griffin

Subject: Medicine & Pharmacology, Pediatrics Keywords: post-marketing surveillance; vaccine safety; pertussis; Tdap; pregnancy; infant

Online: 18 July 2019 (09:26:02 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0155.v1

Dielectric Properties of Serum in Children with Suspected Immunodeficiency and Suffering from Recurrent Respiratory Infections

Gerard Pasternak, Katarzyna Pentoś, Deta Łuczycka, Maria Kaźmierowska-Niemczuk, Aleksandra Lewandowicz-Uszyńska

Subject: Medicine & Pharmacology, Pediatrics Keywords: immune system; immunedeficiency; respiratory tract infections; children; impedance; serum; laboratory diagnostics

Online: 11 July 2019 (09:12:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0435.v2

Assessment of Left Ventricular Diastolic Function in Children Undegoing Hemodialysis. A Mini Review

Ljiljana Sulovic, Vladimir Sulovic, Zorica Zivkovic, Maja Vasic, Nenad Sulovic

Subject: Medicine & Pharmacology, Pediatrics Keywords: chronic kidney disease; hemodialysis; cardiovascular disease; echocardiography; child

Online: 4 July 2019 (10:37:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0048.v1

Vitamin D and ω-3 Supplementations in Mediterranean Diet During the 1st Year of Overt Type 1 Diabetes: A Cohort Study

Francesco Cadario, Erica Pozzi, Stefano Rizzollo, Marta Stracuzzi, Sheila Beux, Alberto Giorgis, Deborah Carrera, Fabiola Fullin, Sergio Riso, Angela Maria Rizzo, Gigliola Montorfano, Marco Bagnati, Umberto Dianzani, Philippe Caimmi, Gianni Bona, Camillo Ricordi

Subject: Medicine & Pharmacology, Pediatrics Keywords: cholecalciferol; omega3; EPA; DHA; arachidonic acid; AA/EPA ratio; type 1 diabetes; remission period; honeymoon period

Online: 3 July 2019 (08:10:44 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201907.0002.v1

Diagnostic and Prognostic Value of Transcranial Magnetic Stimulation in Mucopolysaccharidosis-Related Cervical Myelopathy

Mariagiovanna Cantone, Giuseppe Lanza, Alice Le Pira, Rita Barone, Giovanni Pennisi, Rita Bella, Manuela Pennisi, Agata Fiumara

Subject: Medicine & Pharmacology, Pediatrics Keywords: motor evoked potentials lysosomal disorders; cortical-spinal tract; spinal cord compression; cervical myelopathy; clinical neurophysiology

Online: 1 July 2019 (11:05:52 CEST)

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