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Preprint ARTICLE | doi:10.20944/preprints201704.0145.v1

Five Phases Music Therapy (FPMT) in Chinese Medicine: Fundamentals and Application

Hui Zhang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: emotion and will; music therapy; five phases; five phases music therapy; psychology

Online: 24 April 2017 (05:37:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0709.v1

COVID-19 Suicide among Adolescents and Youths during the Lockdown: An Exploratory Study based on Media Reports

Md. Dilshad Manzar, Abdulrhman Albougami, Norina Usman, Mohammed A. Mamun

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; lockdown; psychological impacts; self-harm; suicide; COVID-19 suicide; teenage suicide; adolescent suicide; youth suicide; press reporting suicide

Online: 31 August 2020 (05:43:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0169.v1

A Longitudinal Approach to Biological Psychiatric Research: The PsyCourse Study

Monika Budde, Heike Anderson-Schmidt, Katrin Gade, Daniela Reich-Erkelenz, Kristina Adorjan, Janos L. Kalman, Fanny Senner, Sergi Papiol, Till F. M. Andlauer, Ashley L. Comes, Eva C. Schulte, Farah Klöhn-Saghatolislam , Anna Gryaznova, Maria Hake, Kim Bartholdi, Laura Flatau, Markus Reitt, Silke Quast, Sophia Stegmaier, Milena Meyers, Barbara Emons, Ida Sybille Haußleiter, Georg Juckel, Vanessa Nieratschker, Udo Dannlowski, Max Schmauß, Jörg Zimmermann, Jens Reimer, Sybille Schulz, Jens Wiltfang, Eva Reininghaus, Ion-George Anghelescu, Volker Arolt, Bernhard T. Baune, Carsten Konrad, Andreas Thiel, Andreas J. Fallgatter, Christian Figge, Martin von Hagen, Manfred Koller, Fabian U. Lang, Moritz E. Wigand, Thomas Becker, Markus Jäger, Detlef E. Dietrich, Sebastian Stierl, Harald Scherk, Carsten Spitzer, Here Folkerts, Stephanie H. Witt, Franziska Degenhardt, Andreas J. Forstner, Marcella Rietschel, Markus M. Nöthen, Peter Falkai, Thomas G. Schulze, Urs Heilbronner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Schizophrenia; bipolar; psychosis; depression; polygenic risk score; diagnosis; RDoC

Online: 27 October 2017 (11:58:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints201609.0022.v1

Art of Music, as Harmony of the Spheres and Autism Spectrum Disorder

Bharathi Geetha, Thangaraj Sugunadevi, Babu Srija, Nagarajan Laleethambika, Vellingiri Balachandar

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Pervasive developmental disorder; Autism spectrum disorder (ASD); brain network; Theory of Mind (ToM); Music Therapy (MT); therapeutic effect

Online: 6 September 2016 (11:53:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0041.v1

Association between Excessive Use of Mobile Phone and Insomnia and Depression among Japanese Adolescents

Tamura Haruka, Tomoko Nishida, Akiyo Tsuji, Hisataka Sakakibara

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: adolescents; depression; insomnia; mobile phone; Japanese

Online: 7 April 2017 (04:33:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0093.v2

Mental Health in Cypriot Citizens of the Rural Health Centre Kofinou

Georgios Stavrou, Eleni Jelastopulu, Lefkios Paikousis, Georgios Charalambous

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; anxiety; emotional distress; HADS; GDS; Health Centre

Online: 11 August 2016 (11:05:44 CEST)

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Objective: The main purpose of this study was to investigate the mental health of Cypriot citizens, living in the current difficult period of economic recession. Specific objective was to investigate the different factors (gender, age, socio-economic factors, etc.) that may affect the levels of emotional distress, anxiety and depression in visitors of the Rural Health Centre of Kofinou. Materials and Methods: The sample consisted of total 300 Cypriots who visited Kofinou Health Centre in the period between August and September 2015. For the middle-aged citizens the Greek version of the HADS scale (Hospital Anxiety Depression Scale) was administered to 150 persons (Michopoulos I., 2007), while for the visiting senior citizens (aged over 65 years) the Greek version of the GDS scale (Geriatric Depression Scale) was used (Fountoulakis K., et al., 1999). All analyses were performed with the social science analysis package SPSS (version 21). Results: HADS: A total of 150 people of average age 47±11,5 years (23-64), were 56% women, while the 77.3% stated they had drastic reduction of income as well as 46.7% suffered from chronic disease. The 36.6% and 28.7% of the visitors showed moderate and severe forms of anxiety and depression, accordingly. Higher emotional distress is associated with lower educational level (p<0,001). Moreover, patients with low income have higher levels of anxiety (p=0,003), depression (p=0,036) and total emotional distress (p=0,007), while those with chronic disease have a higher stress (p<0,001), depression (p<0,001) and total emotional distress symptoms (p<0,001) compared to non - patients. GDS: 150 patients out of which 77 were women (51.3%). The average age of participants was 72±5,5 years. 93(62%) participants declared a drastic reduction of income due to the financial crisis while 139 (92.7%) stated they had chronic disease. 53 participants (35.3%) think they have symptoms of depression after the economic crisis. The women showed higher level of geriatric depression symptoms than men (p<0.001). Higher levels of depression is associated with lower income (p=0.001). Conclusions: The study shows that stress levels, depression and emotional distress are increased in specific population groups. The main factors affecting the mental health of the participants are the presence of chronic disease, income and level of education.

Preprint ARTICLE | doi:10.20944/preprints201611.0056.v1

Clinical Decision-Making in the Treatment of Schizophrenia: Focus on Long-Acting Injectable Antipsychotics

Ludovic Samalin, Marion Garnier, Candy Auclair, Pierre-Michel Llorca

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: long-acting injectable; antipsychotic; decision-making; guidelines; schizophrenia

Online: 10 November 2016 (07:00:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0083.v1

Psychological Distress among Bangladeshi Dental Students during the COVID-19 Pandemic

Farah Sabrina, Mohammad Tawfique Hossain Chowdhury, Sujan Kanti Nath, Ashik Abdullah Imon, S M Abdul Quader, Md Shahed Jahan, Ashek Elahi Noor, Clopa Pina Podder, Unisha Gainju, Rina Niroula, Muhammad Aziz Rahman

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Psychological distress; Fear; Coping; COVID-19; Bangladesh; Dental; Mental health

Online: 6 December 2021 (15:22:59 CET)

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Preprint REVIEW | doi:10.20944/preprints201703.0077.v1

Effects of Forest Therapy on Depressive Symptoms among Adults: A Systematic Review

Insook Lee, Heeseung Choi, Kyung-Sook Bang, Sungjae Kim, MinKyung Song, Buhyun Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: systematic review; forest therapy; depression; adults

Online: 14 March 2017 (08:45:56 CET)

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Working Paper REVIEW

A New Perspective of Genetic Associations to the Cause of Multiple Sclerosis: The Role of Genes Expressed on Chromosomes 2 and 5

Robin Terese Montesano

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: multiple sclerosis; MS; cause; genes; polygenic; heredity; autoimmune; diet; depression; fatigue; suicide; seizures; bowel disorders; thyroid; mitochondria; chromosome 2; chromosome 5; glial cells; sunlight; vitamin D3; ultraviolet radiation; melanocyte stimulating hormone; melanocyte concentrating hormone; stress

Online: 22 July 2019 (04:37:27 CEST)

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The literature on the causation of multiple sclerosis (MS), both genetic and environmental, extends over hundreds of years, with no firm conclusions on the exact role of autoimmunity and lifestyle. The epidemiology of MS was the basis for this review, but with a new, extensive examination of genes pertaining to each disorder, and disease of first, and second, degree relatives of those with MS. The author’s motivation was to discover some relationship between MS, and notable familial conditions, as the heredity of MS is concluded to be 30%, and the disorders had a chronic and/or idiopathic nature. This investigation hoped to further understand the randomness of MS- who acquires it, and what symptoms develop- after the author’s decades of observing several incidences of multiple members developing MS in a single family. Online databases for the human genome were used to link genes to MS, and symptoms, including excessive depression, fatigue and suicide rates, in coordination with linking genes for specific familial conditions including seizures, stroke, mental illness, bowel disorders, and thyroid conditions. Interesting associations were found, notably a cluster of Th2 cytokines, known to cure the animal model of MS, important receptors for neurotransmitters and hormones, a gene specific to Epstein Barr Virus, and potential genes for mitochondrial dysfunction. The results surprised the author, showing polygenic regions of chromosome 2 and 5, especially a cluster at loci 5q31-q33, may be dysregulated. The conclusion agrees with past hypotheses MS results not from a single gene, but from various genes, including those expressed in glial cells. The individual theories to the causation of MS, starting with Charcot may be explained by multiple pathways converging into a single disease outcome. In coordination with a sunlight factor, chromosome 2 appears to mediate the immune system, and inflammation, through ultraviolet radiation producing vitamin D3 in the skin, but additionally through peptides formed in the melanocyte stimulating and concentrating hormone class. The impact of stress in MS could be primary, given the loci of several stress-related and stress-modulated genes on these chromosomes, and calls for more appreciation of, and greater care for, the MS patients’ state of mind.

Preprint ARTICLE | doi:10.20944/preprints201610.0065.v1

Views and Preferences for Nicotine Products as an Alternative to Smoking: A Focus Group Study of People Living with Mental Disorders

Carla Meurk, Pauline Ford, Ratika Sharma, Lisa Fitzgerald, Coral Gartner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: nicotine products; tobacco harm reduction; people living with mental illness; qualitative research; consumer preferences

Online: 17 October 2016 (10:49:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0145.v2

Five Phases Music Therapy (FPMT) in Chinese Medicine: Fundamentals and Application

Hui Zhang, Han Lai

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: emotion and will; music therapy; five phases, five phases music therapy; psychology

Online: 29 November 2017 (09:54:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202107.0255.v1

A Review on Mental Stress Assessment Methods Using EEG Signals

Rateb Katmah, Fares Al-Shargie, Usman Tariq, Fabio Babiloni, Fadwa Al-Mughairbi, Hasan Al-Nashash

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental stress; EEG; data analysis; connectivity network; machine Learning

Online: 12 July 2021 (12:06:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0346.v1

The Mental Health of School-Going Children During Existing Lockdown Situation Due to COVID-19 Pandemic in Bangladesh

Muhammad Anwar Hossain, Sanjida Rahman, Md Rezaul Karim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health; COVID-19; school-going children; lockdown

Online: 21 May 2020 (15:59:25 CEST)

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Working Paper ARTICLE

Interrogating Hope Theory

Jacob Shivley

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: interrogating hope theory, hope theory, hope, the hope scale, positive psychology

Online: 25 March 2019 (09:53:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0262.v1

Chronic Fatigue and Fibromyalgia Symptoms are Key Components of Deficit Schizophrenia and are Strongly Associated with Activated Immune-Inflammatory Pathways

Abbas Almulla, Hussein Al-Hakeim, Mokhlad Abed, André Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Chronic fatigue syndrome, inflammation, neuro-immune, physio-somatic, schizophrenia, cytokines

Online: 23 July 2019 (11:49:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0116.v3

Network Analysis: A Novel Approach to Understand Suicidal Behavior

Derek de Beurs

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; network analysis; symptoms; personalized treatment

Online: 13 February 2017 (11:04:49 CET)

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Working Paper ARTICLE

Short Form 36-Item Health Survey (SF-36) in Patients with Physical Disabilities: Validity and Reliability

Nassim Ahmadi, Mojgan Rajati, Maryam Khazaei Pool, Leili Salehi, Mohammad Ebrahimi, Fatemeh Rajati

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Disabled Persons; Health Status; Iran; Psychometrics; Quality of Life; Reliability

Online: 7 September 2020 (03:24:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0093.v1

Mental Health in Cypriot Citizens of the Rural Health Centre Kofinou

Georgios Stavrou, Eleni Jelastopulu, Lefkios Paikousis, Georgios Charalambous

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; anxiety; emotional distress; HADS; GDS; Health Centre

Online: 9 August 2016 (11:38:27 CEST)

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Objective: The main purpose of this study was to investigate the mental health of Cypriot citizens, living in the current difficult period of economic recession. Specific objective was to investigate the different factors (gender, age, socio-economic factors, etc.) that may affect the levels of emotional distress, anxiety and depression in visitors of the Rural Health Centre of Kofinou. Materials and Methods: The sample consisted of total 300 Cypriots who visited Kofinou Health Centre in the period between August and September 2015. For the middle-aged citizens the Greek version of the HADS scale (Hospital Anxiety Depression Scale) was administered to 150 persons (Michopoulos I., 2007), while for the visiting senior citizens (aged over 65 years) the Greek version of the GDS scale (Geriatric Depression Scale) was used (Fountoulakis K., et al., 1999). All analyses were performed with the social science analysis package SPSS (version 21). Results: HADS: A total of 150 people of average age 47±11,5 years (23-64), were 56% women, while the 77.3% stated they had drastic reduction of income as well as 46.7% suffered from chronic disease. The 36.6% and 28.7% of the visitors showed moderate and severe forms of anxiety and depression, accordingly. Higher emotional distress is associated with lower educational level (p<0,001). Moreover, patients with low income have higher levels of anxiety (p=0,003), depression (p=0,036) and total emotional distress (p=0,007), while those with chronic disease have a higher stress (p<0,001), depression (p<0,001) and total emotional distress symptoms (p<0,001) compared to non - patients. GDS: 150 patients out of which 77 were women (51.3%). The average age of participants was 72±5,5 years. 93(62%) participants declared a drastic reduction of income due to the financial crisis while 139 (92.7%) stated they had chronic disease. 53 participants (35.3%) think they have symptoms of depression after the economic crisis. The women showed higher level of geriatric depression symptoms than men (p<0.001). Higher levels of depression is associated with lower income (p=0.001). Conclusions: The study shows that stress levels, depression and emotional distress are increased in specific population groups. The main factors affecting the mental health of the participants are the presence of chronic disease, income and level of education.

Preprint REVIEW | doi:10.20944/preprints202002.0084.v1

The Microbiota-gut-immune-glia (MGIG) Axis in Major Depression

Leszek Rudzki, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; leaky gut; microbiota; cytokines; neuroimmunomodulation; oxidative stress

Online: 6 February 2020 (10:30:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0135.v1

Lowered Zinc and Copper Levels in Drug-Naïve patients with Major Depression: Effects of Antidepressants, Ketoprofen and Immune Activation

Ahmed Jasim Twayej , Hussein Al-Hakeim, Arafat Hussein Al-Dujaili , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Depression, inflammation, neuro-immune, interleukins, ketoprofen, zinc

Online: 14 January 2019 (11:47:42 CET)

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There is now evidence that major depression is accompanied by lowered serum zinc, an immune-inflammatory biomarker. However, the effect of anti-inflammatory drugs as adjuvant to antidepressants on serum zinc and copper in relation to pro- and anti-inflammatory cytokines are not studied. The aim of the present work is to examine the effects of treatment with sertraline with and without ketoprofen on serum levels of zinc and copper in association with immune-inflammatory biomarkers in drug-naïve major depressed patients. We measured serum zinc and copper, interleukin (IL)-1β, IL-4, IL-6, IL-18, interferon (IFN)-γ, and transforming growth factor (TGF)-β1 in 40 controls and 133 depressed patients. The clinical efficacy of the treatment was measured using the Beck Depression Inventory-II (BDI-II) at baseline and 8 weeks later. In drug-naïve major depressed patients we found significantly reduced baseline levels of serum zinc and copper in association with upregulation of all cytokines, indicating activation of the immune-inflammatory responses system (IRS) as well as the compensatory immune regulatory system (CIRS). Treatment with sertraline significantly increased zinc and decreased copper levels, while ketoprofen did not have a significant add-on effect on zinc but attenuated the suppressant effects of sertraline on copper levels. During treatment, there was a significant inverse association between serum zinc and activation of the IRS/CIRS. The improvement in the BDI-II during treatment was significantly associated with increments in serum zinc coupled with attenuation of the IRS/CIRS. In conclusion, lower serum zinc is a hallmark of depression, while increments in serum zinc and attenuation of the immune-inflammatory response during treatment appear to play a role in the clinical efficacy of sertraline. Intertwined changes in zinc levels and the immune response play a role in the pathophysiology of major depression and participate in the mechanisms underpinning the clinical efficacy of antidepressants.

Preprint ARTICLE | doi:10.20944/preprints201710.0047.v2

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Adrenal Axis Dysregulation Model in Stress Induced Genesis of Psychiatric Disorders

Ashutosh Kumar, Pavan Kumar, Muneeb A. Faiq, Vikas Pareek, Khursheed Raza, Sankat Mochan, Pranav Prasoon, Vivek Sharma

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: HPA axis; NGFs; psychiatric disorders; prevention of mental diseases; stress

Online: 4 December 2017 (07:45:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0108.v1

In Schizophrenia, Psychomotor Retardation is Associated with Executive and Memory Impairments, Negative and Psychotic Symptoms, Neurotoxic Immune Products and Lower Natural IgM to Malondialdehyde

Michael Maes, Sunee Sirivichayakul, Buranee Kanchanatawan, Andre F. Carvalho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia, inflammation, nitrosative stress, tryptophan catabolites, cytokines, oxidative stress

Online: 11 January 2019 (10:37:50 CET)

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Preprint REVIEW | doi:10.20944/preprints201712.0051.v1

DBS in Treatment of Post-Traumatic Stress Disorder

Angelo Lavano, Giusy Guzzi, Attilio Della Torre, Serena Marianna Lavano, Raffaele Tiriolo, Giorgio Volpentesta

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: posttraumatic stress disorder; deep brain stimulation; fear extinction; amygdala; prefrontal cortex

Online: 8 December 2017 (07:21:28 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0106.v1

A Comparative Study of the Causes and Methods of Completed Suicide Referred to Legal Medicine Organization in Bushehr Province, South of Iran, 2006-2015

Alireza Raeisi, Mahmo]od Montazeri, Hiyam Hosseini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: completed suicide; hanging out; self-Immolation; Bushehr; Iran

Online: 24 January 2017 (04:16:45 CET)

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Preprint ARTICLE | doi:10.20944/preprints201904.0176.v1

In Major Depression, Increased Serum Dynorphin and Kappa Opioid Receptor Levels are Positively Associated with Mu Opioid Receptor Levels and Immune Activation and Are Attenuated by Nicotine Dependence

Hussein Al-Hakeim, Suhaer Al-Fadhel, Arafat Hussein Al-Dujaili, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; cytokines; inflammation; endogenous opioid; opioid receptor

Online: 16 April 2019 (09:49:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201710.0047.v1

Nerve Growth Factor(s) Mediated Hypothalamic Pituitary Axis Activation Model in Stress Induced Genesis of Psychiatric Disorders

Ashutosh Kumar, Pavan Kumar, Vikas Pareek, Muneeb A. Faiq, Khursheed Raza, Pranav Prasoon, Sankat Mochan, Vivek Sharma

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: HPA axis; NGFs; psychiatric disorders; prevention of mental diseases; stress

Online: 9 October 2017 (09:55:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0074.v1

The Role of Big Data Analytics in Developing System Dynamic Models

Hamed Kianmehr, Nasim Sabounchi, Lina Begdache

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: system dynamics modeling; big data; mental distress; diet

Online: 5 November 2018 (02:34:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0415.v1

Relating the Effect of HPA Axis to the Emotional State of Bipolar II Disorder Patient

Uchenna Michael, Moses Oyesanya

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: HPA axis, Bipolar II disorder, perturbation, cortisol

Online: 23 July 2018 (11:28:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202009.0149.v1

The Relationships between Smartphone Addiction of Middle School Students and Smartphone Usage Types, Depression, ADHD, Stress, Interpersonal Problems, and Parenting Attitude

Youl Pyo Hong, Yeon Ok Yeom, Myung Ho Lim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Smartphone Addiction; Middle School Students; Smartphone Usage Types; Depression; Parenting Attitude

Online: 6 September 2020 (16:27:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202003.0416.v1

Menstruation Distress Is Strongly Associated with Hormone-Immune-Metabolic Biomarkers

Chutima Roomruangwong, Sunee Sirivichayakul, Andressa Keiko Matsumoto, Ana Paula Michelin, Laura de Oliveira Semeao, João Victor de Lima Pedrao, Decio S. Barbosa, Estefania G. Moreira, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: menstrual cycle-related syndrome; neuroimmunomodulation; biomarkers; inflammation; oxidative stress; antioxidants

Online: 29 March 2020 (03:22:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201905.0353.v1

Sleep Disturbances are Consequences or Mediators between Socioeconomic Status and Health: A Scoping Review

Faustin Armel Etindele Sosso, Dimitrios Papadopoulos, Salim R. Surani, Giuseppe Curcio

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sleep disorders; socioeconomic status; mediator; allostatic load; health; scoping review

Online: 29 May 2019 (14:48:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0149.v1

Stressor And Coping Strategies Of People Living With Hiv/aids (PlWHA): A Literature Review

Ahmad Ikhlasul Amal, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Stressor; Coping Strategies; HIV/AIDS

Online: 5 April 2021 (15:55:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0061.v1

Salivary Oxytocin Concentration Changes during a Group Drumming Intervention for Maltreated School Children

Teruko Yuhi, Hiroaki Kyuta, Hisa-aki Mori, Chihiro Murakami, Kazumi Furuhara, Mari Okuno, Masaki Takahashi, Daikei Fuji, Haruhiro Higashida

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: child abuse; maltreatment; intervention; drum playing; salivary; oxytocin

Online: 9 November 2017 (08:43:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0116.v1

A Network Perspective on Suicidal Behaviour

Derek de Beurs

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; networkanalysis; symptoms; personalized treatment

Online: 25 January 2017 (17:19:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0619.v1

Prevalence of Stress in Healthcare Professional During COVID-19 Pandemic in Northeast México: A Remote Fast Survey Evaluation, the Use of an Adapted COVID-19 Stress Scale

Juan Luis Delgado-Gallegos, Rene de Jesus Montemayor-Garza, Gerardo R. Padilla-Rivas, Hector Franco-Villareal, Jose Francisco Islas

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 Mexico; stress in healthcare professionals; COVID-19 stress scale

Online: 26 September 2020 (08:07:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0146.v1

Acupuncture as Add-On Treatment of the Positive, Negative, and Cognitive Symptoms of Patients with Schizophrenia: A Systematic Review

Maurits Van den Noort, Sujung Yeo, Sabina Lim, Sook-Hyun Lee, Heike Staudte, Peggy Bosch

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; psychosis; sleep; sleep disturbances; sleep disorders; integrative medicine; acupuncture; add-on therapy

Online: 23 February 2018 (04:59:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0029.v1

Shared Microglial Mechanisms Underpinning Depression and Fatigue and Their Comorbidities

Adriano José Maia Chaves Filho, Danielle S. Macedo, David Freitas de Lucena, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depressive disorder, microglia, cytokines, neuro-immune, chronic fatigue, oxidative stress

Online: 4 February 2019 (11:41:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202006.0058.v1

From "Leaky Gut" to Impaired Glia-neuron Communication in Depression

Leszek Rudzki, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; leaky gut; microbiota; cytokines; neuroimmunomodulation; oxidative stress; glia; blood-brain barrier; LPS; TLR

Online: 5 June 2020 (15:06:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0249.v1

Can Psychedelics be the Treatment for the Crisis in Psychopharmacology?

Genís Ona, José Carlos Bouso

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health; psychedelics; psychopharmacology; psychiatry; innovative

Online: 24 January 2019 (08:46:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0037.v1

The Plastic Adaptation to Pathology in Psychiatry. Are Patients with Psychiatric Disorders Pathological Experts?

Ali Amad, Paul Expert, Louis-David Lord, Thomas Fovet, Pierre A. Geoffroy

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: neuroplasticity; neuroprogression; psychiatric disorders; brain economy; severe mental illness; biomarkers

Online: 3 December 2018 (16:18:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202006.0124.v1

NegEnt: Cannabidiol-based Aromatherapy - Theoretical Aspects, Pharmacology, Clinical and Research Perspectives, Economic and Social Implications

Tullio Scrimali

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: therapeutic cannabis; cannabidiol; aromatherapy; NegEnt; Herbal Neurocare

Online: 9 June 2020 (13:44:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0356.v1

The Psychological Impact of COVID-19 Pandemic among Communities Living in Dilla Town, Ethiopia, April 2020

Chalachew Kassaw

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: anxiety; depression; stress; coronavirus; Dilla; Ethiopia

Online: 30 June 2020 (08:00:58 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0233.v1

Network Medicine and Alzheimer’s Disease Therapy

Juliet T. Jarrell, Li Gao, David S. Cohen, Xudong Huang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alzheimer’s Disease; network medicine; inflammation; network and system pharmacology; traditional Chinese medicine

Online: 18 April 2018 (07:41:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0077.v1

The Role of Immune and Oxidative Pathways in Menstrual-Cycle Associated Depressive, Physio-Somatic, Breast and Anxiety Symptoms: Modulation by Sex Hormones

Chutima Roomruangwong, Andressa Keiko Matsumoto, Ana Paula Michelin, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Sunee Sirivichayakul, Andre Carvalho, Decio S. Barbosa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual syndrome; depression; anxiety; antioxidants; neuro-immune; inflammation; oxidative stress

Online: 9 January 2020 (08:17:43 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0641.v1

Influence of Socioeconomic Status and Stress Over Quality of Sleep: A Systematic Review

Faustin Armel Etindele Sosso, Aarti Jagannath, Fabricio Ferreira De Oliveira, Salim R. Surani, Vincent Mysliwiec

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: sleep, socioeconomic status, stress, circadian rhythm, allostatic load, mood disorder, social class

Online: 26 October 2018 (16:32:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0116.v2

Network Analysis: A Novel Approach to Understand Suicidal Behavior

Derek de Beurs

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: suicide; network analysis; symptoms; personalized treatment

Online: 8 February 2017 (09:39:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0464.v1

Post-partum Depression in Mothers of Children under 2 years in Military Barracks in Lagos, Nigeria

Alero Ann Roberts, Chisa Mariam Nworka, Esther Oluwakemi Oluwole, Ezekiel Sofela Oridota

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Postpartum depression, Edinburgh Postpartum Depression Scale, general help-seeking, mothers, military barracks

Online: 27 August 2018 (14:59:46 CEST)

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Working Paper ARTICLE

The Menstrual Cycle may not Be Limited to the Endometrium but also may Impact Intestinal Permeability

Chutima Roomruangwong, André F. Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual syndrome; depression; anxiety; fatigue; neuro-immune; progesterone

Online: 21 March 2019 (04:13:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0381.v1

Perceived Stress, Depression and Alcohol Use Disorders in College Students During the COVID-19 Pandemic: A Socio-Economic Dimension

Beata Gavurova, Viera Ivankova, Martin Rigelsky

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Alcohol dependence; Depression; Stress; Gender; Income; Differences; Behavioural disorders; Mental disorders; Socio-economic effects; Pandemic; Isolation; COVID-19; Slovak students

Online: 13 November 2020 (13:24:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201812.0246.v1

An Instrument to Measure Mental Health Professionals’ Beliefs and Attitudes Towards Service Users’ Rights

Francisco José Eiroa-Orosa, Laura Limiñana-Bravo

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health services, attitudes; beliefs; coercion; paternalism; discrimination

Online: 20 December 2018 (10:11:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints202003.0432.v1

Chronic Fatigue Syndrome and Fibromyalgia-Like Symptoms Are an Integral Component of the Phenome of Schizophrenia: Neuro-Immune and Opioid System Correlates

Rana Fadhil Mousa, Hussein Kadhem Al-Hakeim, Amir Alhaidari, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: chronic fatigue syndrome; myalgic encephalomyelitis; schizophrenia; neuroimmunomodulation; inflammation; biomarkers

Online: 29 March 2020 (10:52:40 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202305.2186.v1

Is Histamine, and Not Acetyl-choline, the Missing Link between ADHD and Allergy? The Speer Allergic Tension Fatigue Syndrome Re-visited

Hilario Blasco-Fontecilla

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Diamine oxidase deficiency; attention deficit hyperactivity disorder; histamine; cognition; attention

Online: 31 May 2023 (07:42:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0526.v1

Neuropsychiatric Disorders: Influence of Gut Microbe to Brain Signaling

Mary Scriven, Mary Wall, John F. Cryan, Timothy G. Dinan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: psychiatry; gut microbiome; probiotics

Online: 27 July 2018 (03:22:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints201809.0289.v1

The Role of Aberrations in the Immune-inflammatory Reflex System (IRS) and the Compensatory Immune-regulatory Reflex System (CIRS) in Different Phenotypes of Schizophrenia: The IRS-CIRS Theory of Schizophrenia

Chutima Roomruangwong, Cristiano Noto, Buranee Kanchanatawan, George Anderson, Marta Kubera, Andre F. Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia, immune system, inflammation, cytokines, immune regulatory, CIRS, psychiatry, immunology, psychosis

Online: 17 September 2018 (08:57:53 CEST)

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In this paper we propose a novel theoretical framework, which was previously developed for major depression and bipolar disorder, namely the compensatory immune-regulatory reflex system (CIRS), as applied to the neuro-immune pathophysiology of schizophrenia and its phenotypes, including first episode psychosis (FEP), acute relapses, chronic and treatment resistant schizophrenia (TRS), comorbid depression, and deficit schizophrenia. These schizophrenia phenotypes and manifestations are accompanied by increased production of positive acute phase proteins, including haptoglobin and α2-macroglobulin, complement factors, and macrophagic M1 (IL-1β, IL-6 and TNF-α), T helper (Th)-1 (interferon-γ and IL-2R), Th-2 (IL-4, IL-5), Th-17 (IL-17) and T regulatory (Treg; IL-10 and transforming growth factor (TGF)-β1) cytokines, cytokine-induced activation of the tryptophan catabolite (TRYCAT) pathway as well as chemokines, including CCL-11 (eotaxin), CCL-2, CCL-3 and CXCL-8. While the immune profiles in the different schizophrenia phenotypes indicate activation of the immune-inflammatory response system (IRS), there are simultaneous signs of CIRS activation, including increased levels of the IL-1 receptor antagonist (sIL-1RA), sIL-2R and tumor necrosis factor-a receptors, Th-2 and Treg phenotypes with increased IL-4 and IL-10 production, and increased levels of TRYCATs and haptoglobin, α2-macroglobulin and other acute phase reactants, which have immune-regulatory and anti-inflammatory effects. Signs of activated IRS and CIRS pathways are also detected in TRS, chronic and deficit schizophrenia indicating that these conditions are accompanied by a new homeostatic setpoint between upregulated IRS and CIRS components. In FEP, increased baseline CIRS activity is a protective factor which may predict favorable clinical outcomes. Moreover, impairments in the CIRS are associated with deficit schizophrenia and greater impairments in semantic and episodic memory. It is concluded that CIRS plays a key role in the pathophysiology of schizophrenia by negatively regulating the primary IRS and contributing to recovery from the acute phase of illness. Components of the CIRS may offer promising therapeutic targets for schizophrenia.

Preprint REVIEW | doi:10.20944/preprints201805.0177.v1

Hippocampal Volume Changes in Patients with Mood Disorders: A Systematic Review of MRI Studies

Marcelo Antônio Oliveira Santos, Lucas Soares Bezerra, Alessandra Mertens Brainer-Lima, Ana Rita Ribeiro Marinho Carvalho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: hippocampus volume; mood Disorders; MRI; depression; subiculum; CA1

Online: 11 May 2018 (06:32:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0092.v1

Development of a Novel Staging Model for Affective Disorders Using Partial Least Squares Bootstrapping: Effects of Lipid-Associated Antioxidant Defenses and Neuro-Oxidative Stress

Michael Maes, Juliana Brum Moraes , Ana Congio , Kamila Landucci Bonifacio , Decio Sabbatini Barbosa , Heber Odebrecht Vargas , Ana Paula Michelin , Andre F. Carvalho , Sandra Odebrecht Vargas Nunes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: staging, affective disorders, major depression, bipolar disorder, oxidative, neuro-immune

Online: 7 December 2018 (13:56:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202212.0569.v1

A Scoping Review of Digital Wellbeing in Early Childhood: Definitions, Measurements, Contributors, and Interventions

Simin Cao, Hui Li

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: young children; early childhood; digital; wellbeing; review; definition; measurement; contributor; intervention.

Online: 30 December 2022 (04:29:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0306.v1

Mental Health Issues in Madhya Pradesh: Insights from National Mental Health Survey of India 2016.

Arun Kokane, Abhijit Pakhare, Gopalkrishna Gururaj, Mathew Varghese, Vivek Benegal, Girish Rao, Aravind B A, Mukesh Shukla, Arun Mitra, Kriti Yadav, Rajni Chatterji, Sukanya Ray, Akash Ranjan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Mental disorder, treatment gap, health system, Madhya Pradesh.

Online: 30 January 2019 (09:25:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0098.v2

Prevalence of Mental Disorders and Addictions among the Homeless Population in the Greater Paris Area, France

Anne Laporte, Stéphanie Vandentorren, Marc-Antoine Détrez, Caroline Douay, Yann Le Strat, Erwan Le Mener, Pierre Chauvin

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: homeless; mental health; epidemiology; psychotic disorders; anxiety; mood disorders; alcohol

Online: 16 January 2018 (13:12:32 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0365.v1

Connecting the Dots Between Mental and Menstrual Health

Esther Ajari

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Menstruation; menstrual health; menstrual hygiene; period poverty; mental health; mental disorder

Online: 17 May 2021 (07:51:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0564.v1

Treating Depression in Patients with Borderline Personality Disorder: Clinical Clues on the Use of Antidepressants

Carmine Tomasetti, Gianna Autullo, Andrea Ballerini, Andrea De Bartolomeis, Bernardo Maria Dell'Osso, Alessio Fiorentini, Federico Tonioni, Vincenzo Villari, Domenico De Berardis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: serotonin antagonist/reuptake inhibitors; comorbidity; psychiatric disorders; trazodone; neurobiology; emotion

Online: 19 April 2023 (07:52:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0229.v1

Reaching Out to Rural Caregivers and Veterans with Dementia Utilizing Clinical Video-Telehealth

James S. Powers, Jennifer Buckner

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: rural health; dementia care; telehealth

Online: 18 April 2018 (05:25:13 CEST)

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Context: A clinical video telehealth (CVT) program was implemented improve access and quality of dementia care to patients and their caregivers in rural areas. The program was offered as part of an established dementia clinic/geriatric primary care clinic in collaboration with five community-based outpatient clinics (CBOC’s) affiliated with the Tennessee Valley Healthcare System (TVHS) in middle Tennessee. Telehealth support was provided by a physician – social worker team visit. Methods: Telehealth training and equipment were provided to clinic personnel, functioning part-time with other collateral clinical duties. Patients and caregivers were referred by primary care providers and had an average of 1 to 2 CVT encounters originating at their local CBOC lasting 20 to 30 minutes. Clinical characteristics and outcomes of patients and caregivers receiving CVT support were collected by retrospective electronic medical record (EMR) review. Results: Over a 3-year period 45 CVT encounters were performed on patient-caregiver pairs, followed for a mean of 15 (1-36) months. Some 80% patients had dementia confirmed and 89% of these had serious medical comorbidities, took an average of 8 medications, and resided at a distance of 103 (76-148) miles from the medical center. Dementia patients included 33% with late stage dementia, 25% received additional care from a mental health provider, 23% took antipsychotic medications, 19% transitioned to a higher level of care, and 19% expired an average of 10.2 months following consultation. Caregiver distress was present in 47% of family members. Consult recommendations included 64% community-based long-term care services and supports (LTSS), 36% medications, and 22% further diagnostic testing. Acceptance of the CVT encounter was 98%, with 8770 travel miles saved. Conclusion: CVT is well received and may be helpful in providing dementia care and supporting dementia caregivers to obtain LTSS for high-need older adults in rural areas.

Preprint ARTICLE | doi:10.20944/preprints201805.0382.v1

A Comparison of Dependence Across Different Types of Nicotine Containing Products and Coffee

Karl Fagerström

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: dependence; nicotine; tobacco; coffee

Online: 28 May 2018 (05:16:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0217.v1

An Overview of Mental Health During the COVID-19 Pandemic

Patrick Chen, Yanna Pusica, Dorsa Sohaei, Ioannis Prassas, Eleftherios Diamandis

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; pandemic; mental health; psychological health; anxiety; suicide

Online: 8 March 2021 (13:32:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0140.v1

The Mental Health Status and Intellectual Ability of Unwed Mothers Dwelling in Korea Shelter Homes

Suyeon Jo, Soowon Park, Jung Hae Youn, Bo Kyung Sohn, Hyo Jung Choi, Ji Yeon Lee, Jin Yong Lee, Jun-Young Lee

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: unwed mother; mental health; intellectual ability

Online: 22 February 2018 (09:03:42 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0251.v1

Mental Health Assessment Method Based on Emotion Level Derived from Voice

Shuji Shinohara, Mitsuteru Nakamura, Yasuhiro Omiya, Masakazu Higuchi, Naoki Hagiwara, Shunji Mitsuyoshi, Hiroyuki Toda, Taku Saito, Masaaki Tanichi, Aihide Yoshino, Shinichi Tokuno

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health assessment; vitality; mental activity; voice index; emotion analysis; noninvasiveness

Online: 11 August 2020 (05:33:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0033.v1

Major Depression in Children with β-Thalassemia Major is Strongly Associated with the Number of Blood Transfusions, Iron Overload and Increased Levels of Interleukin-1β

Hussein Kadhem Al-Hakeim, Asawer Hassan Najm, Arafat Hussein Al-Aldujaili, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; cytokines; neuro-immune; inflammation; oxidative stress; antioxidants

Online: 3 September 2019 (16:20:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0142.v1

Feasibility of Children in Disaster: Evaluation and Recovery (CIDER) Protocol for Traumatized Adolescents in South Korea: A Preliminary Study

Mi-Sun Lee, Hyun Soo Kim, Eun Jin Park, Soo-Young Bhang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: CIDER; post-traumatic stress disorder; trauma; adolescent; trauma-focused group psychotherapy

Online: 15 February 2019 (15:04:13 CET)

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Preprint ARTICLE | doi:10.20944/preprints202001.0285.v1

Increased Oxidative Stress Toxicity and Lowered Antioxidant Defenses in Temporal Lobe Epilepsy and Mesial Temporal Sclerosis: Associations with Psychiatric Comorbidities

Michael Maes, Thitiporn Supasitthumrong, Chusak Limotai, Ana Paula Michelin, Andressa Keiko Matsumoto, Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania G. Moreira, Andre Carvalho, Sunee Sirivichayakul, Decio Barbosa, Buranee Kanchanatawan

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: oxidative stress; neuroimmunomodulation; major depression; inflammation; neurotoxicity; schizophrenia

Online: 24 January 2020 (14:46:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202008.0207.v1

The Prevalence and Sociodemographic Correlates of Social phobia in Oman: Online National Survey

Aamal Ambusaidi, Salim Al Huseini, Hiba Alshaqsi, Manal AlGhafri, Moon-Fai Chan, Nasser Al-Sibani, Samir Al-Adawi

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Social Anxiety Disorder; Social Phobia, Online Survey; Adult, Oman; Liebowitz Social Anxiety Scale

Online: 8 August 2020 (09:39:49 CEST)

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Preprint REVIEW | doi:10.20944/preprints202205.0413.v1

Routine Use of Financial Capacity Instruments for Clinical Decisional Capacity Testing: A Scoping Review

Eduard P. Drima

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: financial capacity instruments; Semi-Structured Clinical Interview for Financial Capacity; deci-sional capacity; mild cognitive impairment; gamification

Online: 31 May 2022 (07:37:21 CEST)

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Financial capacity instruments are psychometric tools designed to evaluate individual decisional capacity based on financial decisions. As tests are complex and need special conditions for administration and evaluation, it is difficult to use them in daily geriatric clinics. Our scoping review objective was to evaluate existing financial capacity instruments from the perspective of simplicity and portability. We evaluated one English speaking knowledge database (Medline) using a dedicated MeSH terminology. The review yielded one independent instrument, The Semi-Structured Clinical Interview for Financial Capacity, that can be easy adapted for every-day clinical use. It is simple to understand and perform and do not need trained personnel for administration. It can be finalized in 15 minutes. Initially validated on 261 subjects (with different forms of cognitive impairment), it showed good accuracy and precision mainly in subjects with cognitive impairment. The test is less apt to detect early or fluctuating cognitive impairment. Simplicity, the main advantage of the test, allows gamification fact that increases portability. Familiar images (coins, money) that are used for performing simple tasks does not need complex translation and adaptation. In form of a game, the test is suitable for serial administration, increasing the chance for early capacity reduction detection. Results reflect a physician judgement related to the subjects’ capacity to understand and execute simple financial instructions and not financial proficiency scores. The main limitation of our review is that we investigated only one, English speaking, knowledge database. The scoping strategy generated a financial capacity instrument that can be used in geriatric clinics for early diagnostic of decisional capacity reduction. Further studies are needed to evaluate the reliability and validity of the test in conditions of serial administration and in populations having various financial experience.

Preprint ARTICLE | doi:10.20944/preprints201907.0037.v1

“Doing my profession is also part of worship”: How Clinical Psychologists Address Aspects of Spirituality and Religion in Indonesia

Andrian Liem

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: clinical psychology; cultural psychology; ethic and professionalism; holistic medicine; qualitative methods

Online: 2 July 2019 (09:39:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0095.v1

In Schizophrenia, PON1 Q192R Genotypes and/or Lowered Paraoxonase 1 (PON1) Enzymatic Activity are Significantly Associated with the Deficit Syndrome, Negative Symptoms, Formal Thought Disorders, Psychomotor Retardation, Excitation and Increased IgA Levels to Gram-Negative Microbiota

Andressa Keiko Matsumoto, Michael Maes, Annabel Maes, Ana Paula Michelin , Laura de Oliveira Semeão, João Victor de Lima Pedrão, Estefania Moreira, Buranee Kanchanatawan, Decio S. Barbosa

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: deficit schizophrenia; antioxidants; bacteria; neuro-immune; inflammation; oxidative and nitrosative stress

Online: 9 September 2019 (09:00:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0206.v1

An analysis on Dual Diagnosis Revealed a Possible deviation of Schizophrenia Polygenic Risk Score by Mexican Amerindian Ancestry

Jose Jaime Martínez-Magaña, Thelma Beatriz Gonzalez-Castro, Alma Delia Genis-Mendoza, Carlos Alfonso Tovilla-Zarate, Isela Juarez-Rojop, Erasmo Saucedo-Uribe, Nuria Lanzagorta, Michael Escamilla, Luis Macías-Kauffer, Humberto Nicolini

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Mexican Amerindian, Dual diagnosis, polygenic risk scores, psychiatric diseases, bipolar disorder, schizophrenia, substance use disorder

Online: 12 September 2018 (01:20:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0411.v2

Short but Continuous Natural Pain for Depression Treatment and Beyond

Mingwei Huang

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: pain; depression; treatment; meditation; synaptic plasticity and homeostasis; DNA damage response

Online: 31 May 2018 (09:51:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201906.0243.v1

Serum Agrin and Talin, Two Muscular Proteins, are Significantly Increased in Major Depression and Increased Agrin and Lowered Creatine Phosphokinase are Associated with Chronic Fatigue and Fibromyalgia Symptoms in Depression

Hussein Kadhem Al-Hakeim, Ameer Abdul Razzaq Al-Issa, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; chronic fatigue; fibromyalgia; neuro-immune; inflammation

Online: 24 June 2019 (10:19:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0724.v2

Clozapine: An Updated Overview of Pharmacogenetic Biomarkers, Risks, and Safety—Particularities in the Context of COVID-19

Ana Miruna Dragoi, Ioana Radulescu, Anca Lucia Pop, Bogdana Adriana Năsui, Valentin Varlas, Simona Trifu

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: clozapine; schizophrenia; early-onset; pregnancy; bipolar affective disorder; agranulocytosis; COVID-19; pharmacogenetic

Online: 9 November 2020 (11:48:29 CET)

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Background: Clozapine (CLZ) use is precarious due to its neurological, cardiovascular, and hematological side effects; however, it is the gold standard in therapy-resistant schizophrenia (TRS) in adults and is underused. Objective: to examine the most recent CLZ data on (a) side effects concerning (b) recent pharmacological mechanisms, (c) therapy benefits, and (d) the particularities of the COVID-19 pandemic. Data sources: a search was performed in two databases (PubMed and Web of Science) using the specific keywords "clozapine" and "schizophrenia," "side effects," "agranulocytosis," "TRS," or "bipolar affective disorder (BAF)" for the last ten years. Study eligibility criteria: clinical trials on adults with acute symptoms of schizophrenia or related disorders. Results: We selected 37 studies, randomized controlled trials (RCTs), and clinical case series (CCS), centered on six main topics in the search area: (a) CLZ in schizophrenia, (b) CLZ in bipolar disorder, (c) side effects during the clozapine therapy, (d) CLZ in pregnancy, (e) CLZ in early-onset schizophrenia, and (f) CLZ therapy and COVID-19 infection. Limitations: We considered RCTs and CCS from two databases, limited to the search topics. Conclusions and implications of key findings: (a) Clozapine doses should be personalized for each patient based on pharmacogenetics testing when available; the genetic vulnerability postulates predictors of adverse reactions' severity; patients with a lower genetic risk could have less frequent hematological monitoring; (b) CLZ-associated risk of pulmonary embolism imposes prophylactic measures for venous thromboembolism; (c) convulsive episodes are not an indication for stopping treatment; the plasma concentration of clozapine is a better side effect predictor than the dosage; (d) COVID-19 infection may enhance clozapine toxicity, generating an increased risk of pneumonia. Therapy must be continued with proper monitoring of the white blood count, and the clozapine dose decreased by half until three days after the fever breaks; psychiatrists and healthcare providers must act together. Background: Clozapine (CLZ) use is precarious due to its neurological, cardiovascular, and hematological side effects; however, it is the gold standard in therapy-resistant schizophrenia (TRS) in adults and is underused. Objective: to examine the most recent CLZ data on (a) side effects concerning (b) recent pharmacological mechanisms, (c) therapy benefits, and (d) the particularities of the COVID-19 pandemic. Data sources: a search was performed in two databases (PubMed and Web of Science) using the specific keywords "clozapine" and "schizophrenia," "side effects," "agranulocytosis," "TRS," or "bipolar affective disorder (BAF)" for the last ten years. Study eligibility criteria: clinical trials on adults with acute symptoms of schizophrenia or related disorders. Results: We selected 37 studies, randomized controlled trials (RCTs), and clinical case series (CCS), centered on six main topics in the search area: (a) CLZ in schizophrenia, (b) CLZ in bipolar disorder, (c) side effects during the clozapine therapy, (d) CLZ in pregnancy, (e) CLZ in early-onset schizophrenia, and (f) CLZ therapy and COVID-19 infection. Limitations: We considered RCTs and CCS from two databases, limited to the search topics. Conclusions and implications of key findings: (a) Clozapine doses should be personalized for each patient based on pharmacogenetics testing when available; the genetic vulnerability postulates predictors of adverse reactions' severity; patients with a lower genetic risk could have less frequent hematological monitoring; (b) CLZ-associated risk of pulmonary embolism imposes prophylactic measures for venous thromboembolism; (c) convulsive episodes are not an indication for stopping treatment; the plasma concentration of clozapine is a better side effect predictor than the dosage; (d) COVID-19 infection may enhance clozapine toxicity, generating an increased risk of pneumonia. Therapy must be continued with proper monitoring of the white blood count, and the clozapine dose decreased by half until three days after the fever breaks; psychiatrists and healthcare providers must act together.

Preprint ARTICLE | doi:10.20944/preprints201907.0293.v1

Increased Serum Immunoglobulin Responses to Gut Commensal Gram-Negative Bacteria in Unipolar Major Depression and Bipolar Disorder Type 1, Especially When Melancholia is Present

Denitsa Simeonova, Drozdstoy Stoyanov, Jean–Claude Leunis, Andre F. Carvalho, Marta Kubera, Marianna Murdjeva, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; bipolar disorder; gut; bacterial translocation; LPS; oxidative stress; neuro-immune; immunology; psychiatry

Online: 26 July 2019 (00:38:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0236.v1

Total and Ionized Calcium and Magnesium Are Significantly Lowered in Drug-Naïve Depressed Patients: Effects of Antidepressants and Associations with Immune Activation

Arafat Hussein Al-Dujaili , Hussein Kadhem Al-Hakeim, Ahmed Jasim Twayej , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: depression; neuro-immune; cytokines; inflammation; indoleamine 2,3-dioxygenase

Online: 26 February 2019 (11:05:49 CET)

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Major depressive disorder (MDD) is associated with changes in the levels of the cations calcium (Ca) and magnesium (Mg) as well as circulating pro- and anti-inflammatory cytokines. The immune-inflammatory nature of MDD has encouraged researchers to use anti-inflammatory drugs as an adjuvant treatment for MDD. However, the effect of this treatment on cation levels has not been studied. The present study examined a) differences in both cations between drug-naïve MDD patients and controls, and b) the effects of a combination of sertraline and ketoprofen, an anti-inflammatory drug, on Ca and Mg (both total and ionized). In the same patients we also examined the associations between both cations and IL-1β, IL-4, IL-6, IL-18, IFN-γ, TGF-β1, zinc and indoleamine 2,3-dioxygenase (IDO). Clinical improvement was estimated using the Beck Depression Inventory-II (BDI-II) at baseline and after follow up for two months. Serum Ca and Mg (total and ionized) were significantly lower in MDD patients as compared with controls, while treatment significantly increased calcium but decreased magnesium levels. There were significant and inverse correlations between the BDI-II scores from baseline to endpoint and Ca (both total and ionized), but not Mg, levels. The effects of calcium on the BDI-II score remained significant after considering the effects of zinc, IDO and an immune activation z unit weighted composite score based on the sum of all cytokines. There was a significant and inverse association between this immune activation index and calcium levels from baseline to endpoint. In conclusion, reduced levels of both cations play a role in the pathophysiology of major depression. Increased calcium levels are coupled to the clinical efficacy of antidepressants and attenuation of immune activation. The suppressant effect of antidepressants on Mg levels may be a side effect of those drugs. New antidepressant treatments should be developed that increase the levels both Ca and Mg.

Preprint ARTICLE | doi:10.20944/preprints201812.0131.v1

Ketoprofen as an Add-on Treatment to Sertraline for Drug-Naïve Major Depressed Patients: Normalization of Plasma Levels of Indoleamine-2,3-Dioxygenase in Association with Pro-Inflammatory and Immune Regulatory Cytokines

Hussein Al-Hakeim, Ahmed Jasim Twayej , Arafat Hussein Al-Dujaili , Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Major depressive disorder (MDD), ketoprofen, TGF-β1, INF-γ, IDO, immune, inflammation

Online: 11 December 2018 (13:52:50 CET)

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Preprint ARTICLE | doi:10.20944/preprints202007.0499.v1

Executive Functions and Cannabis Use in Adolescents

Alessandro Frolli, Maria Carla Ricci, Antonella Cavallaro, Agnese Lombardi, Grazia Maria Giovanna Pastorino, Francesca Felicia Operto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: adolescents; cannabis; cognition; working memory; executive functions

Online: 22 July 2020 (05:42:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0078.v1

Reduced Grey Matter Volume in Frontal and Temporal Areas in Depression: A Voxel Based Morphometry Study

Sevdalina Kandilarova, Drozdstoy Stoyanov, Nickolay Sirakov, Michael Maes, Karsten Specht

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depressive disorder, bipolar disorder, structural MRI, grey matter volume, voxel-based morphometry

Online: 8 February 2019 (09:30:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201807.0364.v1

Emergency and Mental Health Nurses’ Perceptions and Attitudes towards Alcoholics

Jesús Molina-Mula, Antonio González-Trujillo, Margarita Simonet-Bennassar, GIBED Balearic Nursing Drug Addiction Research Group

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: alcoholism, health professionals’ attitudes, social perception, drugs-adictions

Online: 19 July 2018 (15:18:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202001.0138.v1

The Endogenous Opioid System in Schizophrenia and Treatment Resistant Schizophrenia: Increased Plasma Endomorphin 2, and κ and μ Opioid Receptors are Associated with Interleukin-6

Shatha Rouf Moustafa, Khalid F. Al-Rawi, Arafat Hussein Al-Dujaili, Thitiporn Supasitthumrong, Hussein Kadhem Al-Hakeim, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: inflammation; Schizophrenia; treatment resistance; neurocognition; neuroimmunomodulation

Online: 13 January 2020 (04:15:01 CET)

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Working Paper REVIEW

Narrative Review: The (Mental) Health consequences of the Northern Iraq offensive of ISIS in 2014 for female Yezidis

Pia Jäger, Claudia Rammelt, Notburga Ott, Angela Brand

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: Yezidi/ Yazidi; ISIS / IS; Northern Iraq offensive; Iraq / Syrian civil war; women's mental health; PTSD

Online: 24 June 2019 (09:11:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0314.v1

Activation of the Immune-Inflammatory Response System and the Compensatory Immune-Regulatory Reflex System in Antipsychotic Naive First Episode Psychosis

Mariane Nunes Noto, Michael Maes, Sandra Odebrecht Vargas Nunes, Vanessa Kiyomi Ota, Ana C. Rossaneis, Waldiceu A. Verri Jr., Quirino Cordeiro, Sintia Iole Belangero, Ary Gadelha, Rodrigo Affonseca Bressan, Cristiano Noto

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; first episode psychosis; antipsychotic; immune; inflammation; cytokines

Online: 17 September 2018 (14:13:38 CEST)

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Background: First episode psychosis (FEP), schizophrenia and affective disorders are accompanied by activation of the immune inflammatory response system (IRS). The compensatory immune-regulatory reflex system (CIRS) is a regulatory immune response that is induced by the IRS but exerts negative feedback through, for example, increased levels of anti-inflammatory cytokines such as IL-4, IL-13 and IL-10. Different phenotypes of schizophrenia may exhibit distinct IRS and CIRS immune profiles.Aims: This study aims to examine the IRS and CIRS components, including macrophagic M1, T-helper (Th)-1, Th-2, Th-17 and T-regulatory (Treg) phenotypes, in antipsychotic-naïve FEP patients before and after risperidone treatment.Methods: We included 31 antipsychotic-naïve FEP patients who had measurements of IRS and CIRS biomarkers before and after treatment with risperidone for 10 weeks, and 22 healthy controls.Results: Antipsychotic-naive FEP patients showed interrelated increments in M1, Th-1, Th-2, Th-17 and Treg phenotypes and a relatively greater IRS response (especially granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-6 and IL-12) as compared with the CIRS response (IL-4, IL-13, IL-5 and IL-10). Inflammatory markers, especially IL-6 and IL-8, were significantly correlated with negative, psychotic, affective and excitation symptom dimensions. Treatment with risperidone significantly suppressed the IRS and CIRS. Baseline levels of CIRS biomarkers, especially higher soluble tumor necrosis factor receptor-1 and IL-10 predicted clinical improvement during treatment.Discussion: Our findings indicate that FEP is characterized by robust IRS (M1 + Th-1 + Th-17) and CIRS responses, suggesting that monocytes, macrophages, Th-1, Th-2, Th-17 and Treg cells are activated. The findings indicate that a) FEP patients are prone to the detrimental effects of M1, Th-1, Th-17 and Th-2 cells, which may contribute to long-lasting abnormalities in brain circuitry; and b) in FEP, the CIRS may contribute to recovery from the acute phase of illness. Enhancing the CIRS is a new drug target to treat FEP.

Preprint ARTICLE | doi:10.20944/preprints201902.0182.v1

Breakdown of the Paracellular Tight and Adherens Junctions in the Gut and Blood Brain Barrier and Damage to the Vascular Barrier in Patients with Deficit Schizophrenia

Michael Maes, Sunee Sirivichayakul, Buranee Kanchanatawan, Aristo Vojdani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; inflammation; neuro-immune; oxidative stress; TRYCATs; leaky gut

Online: 19 February 2019 (12:14:29 CET)

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Preprint ARTICLE | doi:10.20944/preprints201909.0329.v1

The Uterine-Chemokine-Brain Axis: Menstrual Cycle-Associated Symptoms (MCAS) are in Part Mediated by CCL2, CCL5, CCL11, CXCL8 and CXCL10

Chutima Roomruangwong, Sunee Sirivichayakul, Andre F. Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual syndrome; chemokines; inflammation; neuro-immune; depression

Online: 29 September 2019 (06:29:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0258.v1

Increased Nitro-Oxidative Stress Toxicity as a Major Determinant of Increased Blood Pressure in Mood Disorders

Kamila Landucci Bonifacio, Décio Sabbatini Barbosa, Estefânia Gastaldello Moreira, Carine Farias Coneglian, Heber Odebrecht Vargas, Sandra Odebrecht Vargas Nunes, Juliana Brum Moraes, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: major depression; oxidative and nitrosative stress; antioxidants; inflammation; neuro-immune; biomarkers

Online: 15 May 2020 (16:52:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0012.v1

Biomarker Validation of a New Case Definition of Menstrual Cycle-Associated Syndrome (MCAS)

Chutima Roomruangwong, Michael Maes

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: premenstrual; depression; inflammation; neuro-immune; oxidative stress; antioxidants

Online: 2 December 2019 (14:12:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201901.0141.v1

Upregulation of the Intestinal Paracellular Pathway with Breakdown of Tight and Adherens Junctions in Deficit Schizophrenia

Michael Maes, Sunee Sirivichayakul, Buranee Kanchanatawan, Aristo Vodjani

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: schizophrenia; leaky gut; neuro-immune; inflammation; oxidative stress; TRYCATs; cytokines

Online: 15 January 2019 (07:17:55 CET)

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In 2001, the first author of this paper reported that schizophrenia is associated with an increased frequency of the haptoglobin (Hp)-2 gene. The precursor of Hp-2 is zonulin, a molecule that affects intercellular tight junction integrity. Recently, we reported increased plasma IgA/IgM responses to Gram-negative bacteria in deficit schizophrenia indicating leaky gut and gut dysbiosis. The current study was performed to examine the integrity of the paracellular (tight and adherens junctions) and transcellular (cytoskeletal proteins) pathways in deficit versus non-deficit schizophrenia. We measured IgM responses to zonulin, occludin, E-cadherin, talin, actin and vinculin in association with IgA responses to Gram-negative bacteria, CCL-11, IgA responses to tryptophan catabolites (TRYCATs), immune activation and IgM to malondialdehyde (MDA) and NO-cysteinyl in 78 schizophrenia patients and 40 controls. We found that the ratio of IgM to zonulin + occudin / talin + actin + viculin (PARA/TRANS) was significantly greater in deficit than in non-deficit schizophrenia and higher in schizophrenia than controls and was significantly associated with increased IgA responses to Gram-negative bacteria. IgM responses to zonulin were positively associated with schizophrenia (versus controls), while IgM to occludin was significantly associated with deficit schizophrenia (versus non-deficit schizophrenia and controls). A large part of the variance (90.8%) in negative and PHEM (psychosis, hostility, excitation and mannerism) symptoms was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, IgM to E-cadherin and malondialdehyde (MDA) and memory dysfunctions, while 53.3% of the variance in the latter was explained by PARA/TRANS ratio, IgA to Gram-negative bacteria, CCL-11, TRYCATs and immune activation. The results show an upregulated paracellular pathway with breakdown of the tight and ahherens junctions and increased bacterial translocation in deficit schizophrenia. These dysfunctions in the intestinal paracellular route together with lowered natural IgM, immune activation and production of CCL-11 and TRYCATs contribute to the phenomenology of deficit schizophrenia.

Preprint ARTICLE | doi:10.20944/preprints202008.0606.v1

Stigma and Life Satisfaction among Out-of-School Korean Youths: The Mediating Roles of Self-Esteem and Depression

Myong Sun Cho

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: life satisfaction; depression; self-esteem; stigma; out of school youth; structural equation modeling

Online: 27 August 2020 (09:02:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0346.v2

The Mental Health of School-Going Children During Existing Lockdown Situation Due to COVID-19 Pandemic in Bangladesh

Muhammad Anwar Hossain, Sanjida Rahman, Md Rezaul Karim

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: mental health; COVID-19; school-going children; lockdown

Online: 22 July 2020 (07:43:01 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0156.v1

Ketamine as a Novel Psychopharmacotherapy for Eating Disorders: Evidence and Future Directions

Anya Ragnhildstveit, Matthew Slayton, Laura Jackson, Madeline Brendle, Sachin Ahuja, Willis Holle, Claire Moore, Kellie Sollars, Paul Seli, Reid Robison

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: esketamine; ketamine; ketamine assisted psychotherapy; eating disorder; anorexia nervosa; bulimia nervosa; binge eating disorder; pharmacology; psychedelics; treatment

Online: 11 February 2022 (04:30:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202007.0373.v1

Cannabinoids for People with ASD: A Systematic Review of Published and Ongoing Studies

Laura Fusar-Poli, Vito Cavone, Silvia Tinacci, Ilaria Concas, Antonino Petralia, Maria Salvina Signorelli, Covadonga M. Díaz-Caneja, Eugenio Aguglia

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: autism spectrum disorder; cannabinoids; cannabidiol; cannabidivarin; THC; problem behaviors; sleep; epilepsy; side effects.

Online: 17 July 2020 (09:19:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0037.v1

Hygiene Behavior in Face of the Corona Pandemic: Compliance Rates and Associations With Fear, SARS-COV-2 risk, Mental Health and Disability

Sonia Lippke, Franziska M. Keller, Christina Derksen, Lukas Kötting, Alina Dahmen

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; disability; risk factors; communication; medical rehabilitation; psychosomatic patients; general public; infection; physical health; psychological health

Online: 2 September 2021 (12:08:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0342.v1

‘I Can’t Breathe’: Anxiety and Emotion Awareness in Older Adolescents at The Time of Covid-19

Pietro Smirni, Gioacchino Lavanco, Daniela Smirni

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19 pandemic; virus’ transmission; fear of contagion; breathing difficulty; healthy adolescents; emotion awareness; anxiety-state

Online: 15 August 2020 (08:25:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0423.v1

Social and Emotional Loneliness among Older People Living in Nursing Homes in Spain: A Cross-Sectional Study

Miriam Molas-Tuneu, Javier Jerez-Roig, Eduard Minobes-Molina, Laura Coll-Planas, Anna Escribà-Salvans, Pau Farrés-Godayol, Meltem Yildirim, Sandra Rierola-Fochs, Ester Goutan-Roura, Dyego Leandro Bezerra de Souza, Dawn A. Skelton, Jordi Naudó-Molist

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: emotional loneliness; social loneliness; nursing homes; older adults; social isolation

Online: 27 January 2022 (13:25:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints202102.0194.v1

From Recession to Depression? Prevalence and Correlates of Depression, Anxiety, Traumatic Stress and Burnout in Healthcare Workers During the COVID-19 Pandemic in Greece: A Multi-Center, Cross-Sectional Study

Sofia Pappa, Nikolaos Athanasiou, Nikolaos Sakkas, Stavros Patrinos, Elpitha Sakka, Zafeiria Barmparessou, Stamatoula Tsikrika, Andreas Adraktas, Athanasia Pataka, Ilias Migdalis, Sofia Gida, Paraskevi Katsaounou

Subject: Medicine And Pharmacology, Psychiatry And Mental Health Keywords: COVID-19; health care workers; Greece; mental health; depression; anxiety; traumatic stress; burnout

Online: 8 February 2021 (11:41:59 CET)

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Medicine and Pharmacology