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Preprint ARTICLE | doi:10.20944/preprints201906.0030.v1

Is Excessive Prenatal Ultrasonography a Risk Factor for Autism? A Literature Review

Hissa Moammar, Rabi Sulayman

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: autism; autistic spectrum disorder; children; behavior; ultrasonography; prenatal; pregnancy

Online: 4 June 2019 (12:56:37 CEST)

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For the past several decades, abdominal prenatal ultrasonography has been the most significant technology in obstetrics with a long-established application. However, the frequency, exposure time, thermal and cavitation exposure indices, and increased acoustic output of the ultrasonic waves may be harmful to the embryo/fetus and might increase susceptibility to Autism Spectrum Disorder (ASD). The increase in the prevalence of ASD is associated with an affluent ethnicity, high socioeconomic status, and high parental education where prenatal ultrasonography is readily available and affordable. Enhanced biophysical adverse effects may link the analogous increase in prenatal ultrasonography and autism, and prenatal ultrasonography may emerge as a risk factor for autism. Radiography usage provides historical evidence for this fact: the predominant past opinion was that exposure to X-rays during pregnancy caused no significant risk to a fetus. However, the association between X-ray exposure and childhood leukemia was only established 40 years after X-ray use began. This review focuses on excessive PUS usage and ASD development. Public Abstract Advancements in medical technology over the past several decades have made prenatal ultrasound more frequently accessible to expecting mothers during their pregnancy, especially for the affluent. A parallel development in health care is the increase in autism diagnoses (Autism Spectrum Disorder, or ASD) in children of affluent families. There is a general lack of studies of the impact of prenatal ultrasound on fetuses, especially around varying attributes such as frequency, duration of exposure, and thermal and cavitation indices. There is also a historical precedent set, where exposing fetuses to X-rays was not found to be harmful until it was linked to the development of childhood leukemia decades later. This paper seeks to establish a need to further study these attributes of prenatal ultrasound overuse and their possible impact on a developing fetus, with a special focus on the occurrence of Autism.

Preprint ARTICLE | doi:10.20944/preprints201804.0349.v1

Measurement of Immature Granulocytes (IG) Percentage to Assess Severe Bacterial Infection in Latvian Children: A Secondary Data Analysis

Jana Pavare, Ilze Grope, Dace Gardovska

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: bacterial infections; sensitivity; specificity; immature granulocytes; Latvia; child; sepsis

Online: 27 April 2018 (06:09:47 CEST)

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Background: Detection of small proportion of serious bacterial infections (SBI) with potentially life threating course in a large group of children with fever admitted to emergency department (ED) is still complicated. Measurement of immature granulocytes (IG) percentage may be used as a marker of bacterial infections. The aim of the study was to evaluate whether the IG percentage is a useful additional predictive marker of SBI. Methods: This study included 258 children with febrile infections admitted to the ED. Clinical follow-up, microbiological and radiological tests were used as reference standards for the definition of SBI. Study population was categorized into two groups: (i) infected patients with no suspicion of SBI (n = 75); (ii) patients with suspicion of SBI (n = 183). IG percentage, white blood cell count (WBC) and C-reactive protein (CRP) levels were analyzed from the first routine blood samples at hospital admission. Results: A statistically significant difference in IG percentage levels was observed in children with SBI and those without - the mean IG percentage was 1.2% for the SBI group, 0.3% for those without SBI. The cutoff level of IG percentage to predict SBI was 0.45 (84% specificity, 66% sensitivity, 90% positive predictive value). We combine variables and evaluate their additive values. The sensitivity of WBC to detected SBI improved from 74% to 85% when IG percentage was added to the prediction models. When CRP, WBC and IG percentage were combined, the sensitivity to predict SBI increased to 93%, the specificity to 86%. (95% CI 77–93%). Receiver operator characteristic analysis to predict SBI showed an area under the curve (AUC) of 0.80 for IG percentage. Conclusion: Addition of IG percentage to traditionally used markers of SBI as WBC and CRP may help to identify children with serious bacterial infections. Furthermore IG percentage can be rapidly obtained from the traditional full blood count without any extra sampling and costs.

Preprint REVIEW | doi:10.20944/preprints202005.0160.v1

COVID-19 and Kawasaki Like Disease: The Known-Known, the Unknown-Known and the Unknown-Unknown

Aurélie Morand, Diego Urbina, Alexandre Fabre

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Sars-Cov2; Covid-19; Children; Kawasaki disease; toxic shock syndrome

Online: 9 May 2020 (09:01:24 CEST)

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In the end of April nearly 100 cases of children aged between 6 month and 9 years with Kawasaki like disease were reported (mostly in Europe) probably linked to COVID-19. With the increasing awareness of this condition the number of cases reported is increasing worldwide. We aim to sum up the known data about this new entity based on published data (in a case report, a series of 8 cases and in newspapers and society statement) and using our knowledge of classical Kawasaki disease. It seems to be a post infectious disease with an onset between 2-4 weeks after the infection, probably in genetically predisposed children aged between 6 month to 17 years. A very rough estimation of incidence based on current data from Bergamo, Italy, and New York State and a lot assumption is between 0.016% (95% CI:0.013-0.02%) - 0.31% (95% CI: 0.2-0.47%) of infected children. Clinical signs overlaps with Kawasaki disease in some children, but another feature is prominent gastrointestinal manifestations. For the 9 detailed patients most had incomplete presentation for Kawasaki disease (with a mean 1.7 (+/-1.2) criteria per patient for the 5 non fever criterion) and only one had a classical form. In some cases, presentation is closer to toxic shock syndrome or isolated myocarditis. Persistent fever seems to be constant and biological exploration are consistent with inflammation (elevated CRP, ferritin and D-Dimers). Management is described as supportive and children seem to improve rapidly, but can require cardiac or respiratory support. In date of 11 may 2020 there is 4 deaths confirmed linked to these new entities (1 in UK and 3 in New York). Paediatricians and general practitioners need to be aware of these possible evolution following COVID-19 infection. However it seems to be rare and children are probably still spared from most morbidities and mortality linked to COVID-19 infection .There are need of published detailed cohorts to better delineate these entities.

Preprint ARTICLE | doi:10.20944/preprints201609.0116.v1

Newborn Care in the Home and Health Facility: Formative Findings for Intervention Research in Cambodia

Alessandra N. Bazzano, Leah D. Taub, Richard Oberhelman, Chivorn Var

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Neonate; qualitative research; Southeast Asia

Online: 29 September 2016 (11:17:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0416.v1

Human Milk Oligosaccharides: 2’-fucosyllactose (2’-FL) and Lacto-N-neotetraose (LNnT) in Infant Formula

Y. Vandenplas, B. Berger, V.P. Carnielli, J. Ksiazyk, H. Lagström, M. Sanchez Luna, N. Migacheva, J.M.M. Mosselmans, J.C. Picaud, M. Possner, A. Singhal, M. Wabitsch

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: breast feeding; formula feeding; human milk oligosaccharide; 2’-fucosyllactose; Lacto-N-neotetraose; microbiota; bifidobacteria

Online: 23 July 2018 (11:34:09 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201608.0094.v1

Brain Biomarkers of Long-term Outcome of Neonatal Onset Urea Cycle Disorder

Maha Mourad, Johannes Häberle, Matthew Whitehead, Tamar Stricker, Andrea L. Gropman

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: urea cycle disorder; ornithine transcarbamylase deficiency; magnetic resonance imaging; magnetic resonance spectroscopy

Online: 9 August 2016 (12:03:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0113.v1

Perinatal Risk Factors and Genu Valgum Conduce to the Onset of "Growing Pains" in Early Childhood

Angelos Kaspiris, Efstathios Chronopoulos, Elias Vasiliadis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Growing pains; genu valgum; perinatal factors; bone metabolism

Online: 10 August 2016 (15:20:53 CEST)

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Preprint REVIEW | doi:10.20944/preprints202202.0115.v1

Available Evidence Indicates That Pediatric Use of Acetaminophen Adversely Affects Neurodevelopment in Susceptible Babies and Children

William Parker, Esha Patel, John Jones, Zacharoula Konsoula

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acetaminophen; autism; infant; paracetamol; neurodevelopment

Online: 8 February 2022 (13:42:48 CET)

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Preprint REVIEW | doi:10.20944/preprints201810.0002.v1

Role of Probiotics to Prevent and Reduce the Duration of Upper Respiratory Infections in Ambulatory Children: Systematic Review with Network-Meta Analysis

Pedro Gutierrez-Castrellon, Zvi Weizman, Silvia Cruchet, Ener Cagri Dinleyci, Carlos Jimenez-Gutierrez, Gabriel Lopez-Velazquez

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Probiotics, Upper Respiratory Infections, Network Meta-Analysis

Online: 1 October 2018 (10:22:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0049.v1

Vitamin-D Deficiency Predicts Infections in Young North Indian Children: A Secondary Data Analysis

Ranadip Chowdhury, Sunita Taneja, Nita Bhandari, Bireshwar Sinha, Ravi Upadhyay, Maharaj Kishan Bhan, Tor A. Strand

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: vitamin-D deficiency; ALRI; Indian children

Online: 8 November 2016 (10:40:34 CET)

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Preprint ARTICLE | doi:10.20944/preprints201702.0025.v1

Impact of Lower Screening TSH Cutoff Level on the Increasing Incidence of Congenital Hypothyroidism

Violeta Anastasovska, Mirjana Kocova

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: congenital hypothyroidism; incidence; neonatal screening; thyroid-stimulating hormone; cutoff level

Online: 8 February 2017 (10:54:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201808.0295.v1

Review of Biomedical Applications of Contactless Imaging of Neonates using Infrared Thermography and Beyond

Abbas K. AlZubaidi, Yahya Ethawi, Georg M. Schmoelzer, Sherif Sherif, Michael Narvey, Molly Seshia

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: NICU; Physio-features; Neonatal imaging; Infrared thermography; Optical coherence tomography; Tissue optics; Near-infrared imaging; Short-wave infrared imaging; Visible light imaging

Online: 17 August 2018 (02:27:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0207.v1

Diffusion-Weighted MRI and Urinary Activin-A are Correlated with the Degree of Hypoxic Ischemic Encephalopathy in Neonates

Sheren Maher, Mohamed Abdelazim, Mohamed Eissawy, Mahmoud Higazi, Nagwa Okaily

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Activin-A; HIE; MRI; apparent diffusion coefficient; neonates

Online: 28 March 2017 (03:07:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0084.v1

The First Results of Extended Newborn Screening in the Majority and the Roma Ethnic Group in Slovakia

Svetozár Dluholucký, Mária Knapková

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: extended newborn screening; ethnic screening differences; Roma ethnicity

Online: 14 April 2017 (08:31:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0129.v1

Changes in Biochemical Parameters of the Calcium-Phosphorus Homeostasis in Relation to Nutritional Intake in Very-Low-Birth-Weight Infants

Viola Christmann, Charlotte J. W. Gradussen, Michelle N. Körnmann, Nel Roeleveld, Johannes B. Van Goudoever, Arno F.J. Van Heijst

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: blood; bone mineralization; minerals; monitoring; nutrition; renal tubular reabsorption; supplementation; urine

Online: 25 November 2016 (10:14:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0083.v1

Random network models to predict the long term impact of HPV vaccination on genital warts

Javier Díez-Domingo, Víctor Sánchez-Alonso, Rafael-J. Villanueva, Luis Acedo, José-Antonio Moraño, Javier Villanueva-Oller

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Human papillomavirus; Network model; Vaccination strategies

Online: 28 July 2017 (12:32:26 CEST)

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Preprint REVIEW | doi:10.20944/preprints201910.0179.v1

New Insights of Human Parvovirus B19 in Modulating Erythroid Progenitor Cells Differentiation

Shuwen Feng, Dongxin Zeng, Junwen Zheng, Dongchi Zhao

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: human parvovirus B19; nonstructural protein NS1; erythroid progenitor cells; differentiation; GATA; anemia

Online: 16 October 2019 (05:37:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0107.v1

Donor Human Milk Protects against Bronchopulmonary Dysplasia: A Systematic Review and Meta-Analysis

Eduardo Villamor-Martínez, Maria Pierro, Giacomo Cavallaro, Fabio Mosca, Boris W. Kramer, Eduardo Villamor

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: donor human milk; bronchopulmonary dysplasia; breast milk; preterm formula; pasteurization

Online: 12 January 2018 (05:42:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0118.v1

Outing the Elephants: Exploring a New Paradigm for Child Protection Social Work

Ian Hyslop, Emily Keddell

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: child protection; poverty; inequality; neoliberalism; new paradigm

Online: 10 April 2018 (08:21:26 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints201704.0051.v1

Utility of Genetic Testing for Confirmation of Abnormal Newborn Screening in Disorders of Long-Chain Fatty Acids: A Missed Case of Carnitine Palmitoyltransferase 1A (CPT1A) Deficiency

Leah Dowsett, Lauren Lulis, Can Ficicioglu, Sanmati Cuddapah

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: carnitine palmitoyltransferase deficiency; CPT1A; fatty acid oxidation disorders; transaminitis; Ashkenazi Jewish; neonatal screening

Online: 10 April 2017 (06:23:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0058.v1

A Review on Non-Pharmacological Treatments for Pain Management in Newborn Infants

Avneet K. Mangat, Ju-Lee Oei, Kerry Chen, Im Quah-Smith, Georg M. Schmölzer

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: infant; premature; pain; acupuncture; skin to skin contact; sucrose; massage; musical therapy; breastfeeding

Online: 3 August 2018 (04:09:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0185.v1

Early Detection and Diagnosis of Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency Missed by Newborn Screening Using Tandem Mass Spectrometry

Hiroko Shigetomi, Toju Tanaka, Masayoshi Nagao, Hiroyuki Tsutsumi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: SLC25A13; amino acid ratio; citrullinemia; latent liver dysfunction; mitochondrial aspartate-glutamate carrier

Online: 26 December 2017 (10:18:45 CET)

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Preprint REVIEW | doi:10.20944/preprints201711.0204.v1

Pediatric Thermal Burns and Treatment: A Review of Progress and Future Prospects

Elton Mathias, Madhu Srinivas Murthy

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: burns; treatment; pediatric; autograft; biological skin substitute; thermal

Online: 30 November 2017 (14:12:10 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0153.v1

Weekdays and Weekends Variation of Step Count in 9 to 11 Years Old Obese School Children

Sharifah Wajihah Wafa, Nur Nadzirah Aziz, Marhasiyah Rahim

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: childhood; obesity; activPAL; steps; sedentary behavior

Online: 19 March 2018 (10:16:20 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202006.0118.v1

Infliximab Attenuates Paediatric Inflammatory Multisystem Syndrome in SARS-CoV-2 (PIMS-TS)

Joseph Meredith, Cher-Antonia Khedim, Paul Henderson, David C. Wilson, Richard K. Russell

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: paediatric; immunology; infectious disease; gastroenterology

Online: 9 June 2020 (05:11:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0008.v1

Normal Percentiles for Respiratory Rate in Children – Reference Ranges Determined from an Optical Sensor

Anthony Herbert, John Pearn, Stephen Wilson

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Respiratory Rate; Growth

Online: 2 August 2020 (10:38:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0366.v1

A Demographic and Biochemical Analytic of Cases of G6PD Deficiency: A Cross-Sectional Study from the Middle East

Ahmed Al-Imam

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Glucosephosphate Dehydrogenase Deficiency; G6PD; ABO Blood-Group System; Middle East; Arabs.

Online: 16 October 2018 (15:43:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0278.v1

MCP-1/CCL2 in a Bulgarian Cohort of Children with Bronchial Asthma and Cystic Fibrosis

Tsvetelina Velikova, Ekaterina Krasimirova, Snezhina Lazova, Penka Perenovska, Anna Valerieva, Dimitrinka Miteva, Vasil Dimitrov, Maria Staevska, Dobroslav Kyurkchiev, Guergana Petrova

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: monocyte chemoattractant protein-1; MCP-1; C-C motif chemokine ligand 2; CCL2; childhood asthma; bronchial asthma; severe asthma; cystic fibrosis; chronic obstructive pulmonary disease

Online: 23 April 2018 (09:00:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0482.v1

The Associations between Screen Time and Sleep Duration, and Body Mass Index (BMI) in under Five-Year-Old Children

Hossein Sourtiji, Mehdi Rassafiani, Seyed Ali Hosseini, Mohammad Esmaeil Motlagh, Mehdi Noroozi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: screen time; sleep duration; body mass index (BMI); time use

Online: 31 May 2018 (16:34:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0017.v1

Filling the Gaps for Community-Based Programs Managing Treatment and Prevention of Child Malnutrition in Non-Emergency Contexts: Results from the Rainbow Project 2015-17 in Zambia

Stefania Moramarco, Giulia Amerio, Jean Kasengele Chipoma, Karin Nielsen-Saines, Leonardo Palombi, Ersilia Buonomo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: childhood malnutrition; community-based management of acute malnutrition–CMAM; moderate acute malnutrition–MAM; supplementary feeding programs–SFP; Zambia

Online: 1 June 2018 (12:04:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0064.v1

Soluble CD40 Iigand and Oxidative Response Are Reciprocally Stimulated during Shiga Toxin-Associated Hemolytic Uremic Syndrome

Maria J Abrey Recalde, Romina S. Alvarez, Fabiana Alberto, Maria p Mejias, Maria V. Ramos, Romina J. Fernandez Brando, Andrea C. Bruballa, Ramon A. Exeni, Laura Alconcher, Cristina A. Ibarra, María M. Amaral, Marina S. Palermo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: hemolytic uremic syndrome; oxidative stress; blood platelets; shiga toxin 2; CD40L

Online: 18 August 2017 (11:46:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0154.v1

Examination of Demographic Characteristics of Drug and Corrosive Poisonings, Morbidity and Mortality in Children in terms of Emergency Department and Pediatric Surgery

Cengiz Güney, Abuzer Coskun

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: pediatric drug poisoning; emergency department; corrosive; mortality

Online: 11 February 2020 (15:57:47 CET)

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Background: Poisoning constitutes an important part of morbidity and mortality among environmental emergencies that can be prevented, frequent in childhood, requiring rapid diagnosis and treatment. This study aimed was to examine the epidemiological, clinical and therapeutic characteristics of drug and corrosive poisonings in terms of children. Materials and Methods: Between January 2010 and December 2018, 1678 patients between the ages of 1-16 who applied to the emergency department with drug and corrosive poisoning were included in the study. The patients were divided into three groups as 1-5, 6-11 and over 12 years of age, and the substances with known pharmacological agents were divided into 10 groups. The Zargar Classification (7) was used to determine the degree of damage caused by corrosive substances in the esophagus. Results: The mean age of the patients was 8.32 ± 3.23 years (1-15 years). The girl/boy ratio of the cases was 1.18 / 1 and 54.3% were girls. 18.9% of the cases were under five years of age, 61% were between 6-11 years and 20% were older than 12 years. 94.6% of the patients were poisoned by drugs and 5.4% of them were poisoned due to non-drug reasons. Accidental poisoning was most commonly seen in children aged 6-11 and suicides were seen in children older than 12 years. It was found that 62.2% of the poisonings were accidental and 37.8% were suicidal. The most common causes of poisoning were analgesics and paracetamol exposure as a pharmacological agent. Mortality was found to be most common in 1-5 years age group and accidental poisonings. Accidental poisoning was common in girls and suicidal poisoning was common in boys. Grade 3 damage was found endoscopically in all of the mortalities due to corrosive substances. Conclusion: It was found that accidental poisoning was observed in children under five years of age, suicides were observed in children older than 12 years and the most important cause of mortality was due to corrosive substances. Cause-specific rapid diagnosis and treatment will contribute to the reduction of morbidity and mortality.

Preprint ARTICLE | doi:10.20944/preprints201808.0349.v1

A MALDI-TOF MS Approach for Mammalian, Human, and Formula Milks’ Profiling

Laura Di Francesco, Francesco Di Girolamo, Maurizio Mennini, Andrea Masotti, Guglielmo Salvatori, Fabrizio Signore, Emanuela Pietrantoni, Margherita Scapaticci, Isabella Lante, Bianca Maria Goffredo, Oscar Mazzina, Ahmed Ibrahim Elbousify, Paola Roncada, Andrea Dotta, Alessandro Fiocchi, Lorenza Putignani

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: infant nutrition; breast milk; mammalian milk; formula milk; protein similarity profiling; MALDI-TOF mass spectrometry

Online: 20 August 2018 (10:28:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0029.v1

Incidence and Determinants of Health Care Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study

Mamta Dhaneria, Sachin Jain, Poonam Singh, Aditya Mathur, Cecilia Stålsby Lundborg, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: blood stream health care associated infections; neonates; risk factors, antibiotic use, antibiotic resistance; neonatal intensive care unit; India

Online: 5 December 2017 (08:19:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202109.0192.v1

Enzyme Replacement Therapy with Pabinafusp Alfa for Neuronopathic Mucopolysaccharidosis II: an Integrated Analysis of Preclinical and Clinical Data

Roberto Giugliani, Ana Maria Martins, Torayuki Okuyama, Yoshikatsu Eto, Norio Sakai, Kimitoshi Nakamura, Hideto Morimoto, Kohtaro Minami, Tatsuyoshi Yamamoto, Mariko Yamaoka, Toshiaki Ikeda, Sairei So, Kazunori Tanizawa, Hiroyuki Sonoda, Mathias Schmidt, Yuji Sato

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: neuronopathic mucopolysaccharidosis; Hunter syndrome; mucopolysaccharidosis II; idu-ronate-2-sulfatase; enzyme replacement therapy; neurodegeneration; neurocognitive impairment; pabinafusp afa; blood brain barrier

Online: 10 September 2021 (15:49:10 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints202005.0482.v1

Neonatal COVID 19 Pneumonia: Report of the First Case in a Preterm Neonate in Mayotte, an Overseas Department of France

Soumeth Abasse, Leila Essabar, Tereza Costin, Voninavoko Mahistra, Mohamed Kaci, Axelle Braconnier, Roger Serhal, Louis Collet, Abdallah Fayssoil

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID19; preterm neonate; pneumonia; vertical transmission

Online: 31 May 2020 (16:39:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0070.v1

Early Corticosteroid Therapy for Mycoplasma pneumoniae Pneumonia Irrespective of Used Antibiotics in Children

Eun-Ae Yang, Hun-Mi Kang, Jung-Woo Rhim, Jin-Han Kang, Kyung-Yil Lee

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: mycoplasma pneumoniae pneumonia; macrolide antibiotics; antibiotic resistance; corticosteroids; prednisolone; methylprednisolone; children

Online: 7 April 2019 (12:35:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0129.v2

First Aid Practices and Health Seeking Behaviors of Caregivers for Unintentional Childhood Injuries in Ujjain, India: A Community Based Cross-Sectional Study

Ashish Pathak, Nitin Agrawal, Love Mehra, Aditya Mathur, Vishal Diwan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: unintentional childhood injuries; first aid; health seeking, community survey injuries; India

Online: 3 September 2018 (11:41:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0225.v1

COVID-19: Considerations for Children and Adolescents with Diabetes

Devi Dayal

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Coronavirus disease 2019; COVID-19; children; diabetes; type 1 diabetes; type 2 diabetes; recommendations

Online: 14 April 2020 (15:21:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0029.v2

Incidence and Determinants of Health Care Associated Blood Stream Infection at a Neonatal Intensive Care Unit in Ujjain, India: A Prospective Cohort Study

Mamta Dhaneria, Sachin Jain, Poonam Singh, Aditya Mathur, Cecilia Stålsby Lundborg, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: blood stream health care associated infections; neonates; risk factors, antibiotic use, antibiotic resistance; neonatal intensive care unit; India

Online: 30 January 2018 (08:03:04 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints201806.0014.v1

Piloting a Developmental Screening Tool Adapted for East African Children

Mollika A. Sajady, Christopher J. Mehus, Emily C. Moody, Ericka G. Jaramillo, Ezekiel Mupere, Andrew J. Barnes, Sarah E. Cusick

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: development; milestones; screening; poverty; stunting; lead exposure; developmental risk; child health; global health; pediatrics

Online: 1 June 2018 (11:11:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0264.v1

Self-Reported Environmental Tobacco Smoke Exposure and Avoidance Compared with Cotinine Confirmed Tobacco Smoke Exposure among Pregnant Women and Their Infants

Adam Gregory Gavarkovs, Patricia Markham Risica, Donna R. Parker, Ernestine Jennings, Jennifer Mello, Maureen Phipps

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: environmental tobacco exposure; pregnancy; infancy; measurement

Online: 30 March 2018 (09:51:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202202.0296.v1

Managing Care during the COVID-19 Pandemic: The Point of View and Fears of Pediatric Cancer Patients’ Families

Olga Nigro, Giovanna Sironi, Andrea Ferrari, Gabriele Tinè, Gabriele Infante, Francesco Barretta, Matteo Silva, Carlo Alfredo Clerici, Stefano Chiaravalli, Elisabetta Schiavello, Veronica Biassoni, Marta Podda, Cristina Meazza, Filippo Spreafico, Michela Casanova, Monica Terenziani, Roberto Luksch, Maura Massimino

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19; pediatric cancer; managing care

Online: 23 February 2022 (13:57:46 CET)

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Preprint ARTICLE | doi:10.20944/preprints201712.0004.v1

A Retrospective Review of Resuscitation Planning at a Children’s Hospital

Jean Kelly, Jo Ritchie, Leigh Donovan, Carol Graham, Anthony Herbert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: resuscitation planning; paediatric palliative care; advance care planning

Online: 1 December 2017 (10:25:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints202004.0404.v1

Analysis of the Human Breast Milk Microbiome and Bacterial Extracellular Vesicles in Healthy Mothers

Su Yeong Kim, Dae Yong Yi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: milk; human; microbiota; microbiome; extracellular vesicle; breastfeeding

Online: 23 April 2020 (05:11:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202201.0034.v1

Estimating the Male to Female Ratio in Autistic Spectrum Disorder, Defining and Calculating the Biases and Finding the True Number of Girls.

Robert McCrossin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: autistic spectrum disorder, male to female ratio, biases, young women.

Online: 5 January 2022 (10:57:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0081.v1

Population-Based Screening for Severe Combined Immunodeficiency in Manitoba, Canada

J. Robert Thompson, Cheryl R. Greenberg, Andrew Dick, Olga Jilkine, Luvinia Kwan, Tamar S. Rubin, Teresa Zelinski, Marlis L. Schroeder, Paul Van Caeseele

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn screening; SCID; TREC

Online: 3 May 2018 (13:24:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202106.0184.v1

Nutritional, Gastrointestinal and Endo-Metabolic Traps in the Management of Children with Spinal Muscular Atrophy Type 1

Antonio Corsello, Lorenzo Scatigno, Martina Chiara Pascuzzi, Valeria Calcaterra, Dario Dilillo, Sara Vizzuso, Gloria Pelizzo, Elena Zoia, Anna Mandelli, Annalisa Govoni, Alessandra Bosetti, Ruggiero Francavilla, Flavia Indrio, Valentina Fabiano, Gianvincenzo Zuccotti, Elvira Verduci

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: SMA; spinal muscular atrophy type 1; SMN1; nutritional management; enteral nutrition; pediatric gastroenterology; dysphagia; neurological disability; endocrine disorders; precocious pubarche

Online: 7 June 2021 (13:14:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201912.0356.v1

Evaluation of Erythroferrone, Hepcidin, and Iron Overload Status in Iraqi Transfusion-dependent β-Thalassemia Major Patients

Hasan Smesam, Hasan Qazmooz, Sareh Arjmand, Hussein Kadhem Al-Hakeim, Seyed Omid Ranaei‐Siadat,

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Beta-thalassemia, Erythroferrone, Ferritin, Hepcidin, Iron overload

Online: 26 December 2019 (12:37:36 CET)

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Preprint REVIEW | doi:10.20944/preprints202008.0452.v1

How Do We Monitor Oxygenation During The Management of PPHN? Alveolar, Arterial or Mixed Oxygen Tension or Peripheral Saturation?

Praveen Chandrasekharan, Munmun Rawat, Satyan Lakshminrusimha

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: oxygenation; PPHN; oxygen tension

Online: 20 August 2020 (09:50:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0170.v1

The Associations of Physical Activity and Sedentary Behaviour with Mental Health in a Nationwide Sample of Kazakhstan Adolescents

Kwok Ng, Alina Cosma, Shynar Abdrakhmanova, Assel Adayeva

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: WHO-5; well-being; rural; urban

Online: 15 August 2019 (16:17:46 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0504.v1

Gamification Concepts to Promote and Maintain Therapy Adherence in Children with Growth Hormone Deficiency

Sally Radovick, Eli Hershkovitz, Aline Kalisvaart, Marco Koning, Kristine Paridaens, Maged N. Kamel Boulos

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: app; somatotropin; serious games; gamification; digital; mobile health

Online: 26 July 2018 (04:41:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0228.v1

A Web-Based Calculator for Prediction of Severe Neurodevelopmental Impairment in Preterm Infants Using Clinical and Imaging Characteristics

Zachary A. Vesoulis, Nathalie M. El Ters, Maja Herco, Halana V. Whitehead, Amit M. Mathur

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: cerebellar hemorrhage; intraventricular hemorrhage; preterm; MRI; neurodevelopment; outcome prediction; white matter injury

Online: 11 October 2018 (04:21:24 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202007.0219.v1

Linezolid Add-On Rescue Therapy Cured MRSA Necrotizing Pneumonia: A Case Report in a Preterm Infant

Abbas Moosa Al-Omran, Sameer Yaseen Al-Abdi, Hasan Mohammad Al-Amer

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Preterm infant; Necrotizing pneumonia; Methicillin-Resistant Staphylococcus Aureus (MRSA); Pneumatoceles; Linezolid; Vancomycin; Rifampicin

Online: 11 July 2020 (02:10:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0545.v1

Can the Mindful Awareness and Resilience Skills for Adolescents (MARS-A) program be provided online? Voices from the Youth

Nicholas Chadi, Elli Weisbaum, Catherine Malboeuf-Hurtubise, Sara Ahola Kohut, Christine Viner, Miriam Kaufman, Jake Locke, Dzung X. Vo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: qualitative, mindfulness, meditation, chronic illness, adolescents, eHealth

Online: 27 July 2018 (15:34:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202109.0355.v1

Neonatal Pneumothorax- Five Years of Experience in a Tertiary Care Center

Miljana Z Jovandaric, Svetlana J Milenkovic, Ivana R Babovic

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: newborn; therapy; pneumothorax

Online: 21 September 2021 (11:09:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0101.v1

Bezafibrate Improves Mitochondrial Fission and Function in DNM1L Deficient Patient Cells

Liza Douiev, Ruth Sheffer, Gabriella Horvath, Ann Saada

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: DNM1L; Drp1; mitochondrial disease; mitochondrial fission-fusion; Bezafibrate; fibroblast

Online: 8 August 2019 (11:01:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0627.v1

Red Blood Cell Exchange in children with Sickle Cell Disease in French Guiana

Narcisse Elenga, Vincent Vantilcke, Elise Martin, Emma Cuadro, Mickael Parisot, Françoise Maire, Pierre Selles, Thierry Basset

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Erythrocytapheresis; red blood cell exchange; sickle cell disease; target HbS level; heparin locking

Online: 26 July 2020 (02:22:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0170.v1

Mapping Research in Assisted Reproduction Worldwide

D. García, Francesco Alessandro Massucci, Alessandro Mosca, Ismael Ràfols, A. Rodríguez, R. Vassena

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: topic modelling; latent dirichlet allocation; text mining; assisted reproduction; ART; IVF

Online: 15 April 2019 (12:25:12 CEST)

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Study question: What are the current trends of research in Human Assisted Reproduction around the world? Summary answer: USA is the leading country, followed by the UK, China, France and Italy. The largest research area is “laboratory techniques”, although other areas such as “public health”, “quality, ethics and law” and “female factor” are gaining ground worldwide. What is known already: Scientific research, especially in health and medical sciences, aims at addressing specific needs that society (and, especially, patients) perceives as pressing. One of the main challenges for policymakers and research funders alike is therefore to align research priorities to societal needs. We can thus think of research agendas in terms of a demand side (societal needs) and a supply side (research outputs). Research output in Human Assisted Reproduction has expanded in the past years, as indicated by the increasing number of scientific publications in indexed journals in this area. Nevertheless, no map of research related to assisted reproduction has been produced so far, hindering the identification of potential areas of improvement and need. Study design, size, duration: 26,000+ scientific publications (articles, letters, and reviews) on Human Assisted Reproduction produced worldwide between 2005 and 2016 were analyzed. These publications were indexed in PubMed or obtained from reference list of indexed publications included in the analysis.Participants/materials, setting, methods: The corpus of publications was obtained by combining the MeSH terms: “Reproductive techniques”, “Reproductive medicine”, “Reproductive health”, “Fertility”, “Infertility”, and “Germ cells”. Then it was analyzed by means of text mining algorithms (Topic Modeling (TM) based on Latent Dirichlet Allocation (LDA)), in order to obtain the main topics of interest. Finally, these categories were analyzed across world regions and time. Main results and the role of chance: We identified 44 main topics, which were further grouped in 11 macro categories, form larger to smaller: “laboratory techniques”, “male factor”, “quality, ethics and law”, “female factor”, “public health and infectious diseases”, “basic research and genetics”, “pregnancy complications and risks”, “general infertility and ART”, “psychosocial aspects”, “cancer”, and “research methodology”. The USA was the leading country in number of publications, followed by the UK, China, France and Italy. Interestingly, research contents in high income countries is fairly homogeneous across macro-categories, and it is dominated by “laboratory techniques” in Western and Southern Europe, and by “quality, ethics and law” in North America, Australia and New Zealand. In middle income countries we observe that research is mainly performed on “male factor”, and noticeably less on “female factor”. Finally, research on “public health and infectious diseases” predominates in low-income countries. Regarding temporal evolution of research, “laboratory techniques” is the most abundant topic on a yearly basis, and relatively constant over time. However, since production in most of the other categories is increasing, the relative contribution of this research category is actually decreasing. Publication is especially increasing in “public health and infectious diseases” (in all world regions, but especially in low income countries), “quality, ethics and law” (high income countries), and “female factor” (middle income countries). Limitations, reasons for caution: Three main factors might limit the robustness of our work: the textual corpus analyzed is based on abstract and titles, the reproducibility of the stochastic algorithms applied, which may produce slightly differing results at each run, and the interpretation of the topics obtained. Wider implications of the findings: This study should prove beneficial in the design of research strategies and policies that foster the alignment between supply (assisted reproduction research) and demand (society). Study funding/competing interest(s): PTQ-14-06718 of the Spanish MINECO Torres Quevedo programme (FAM).

Preprint CASE REPORT | doi:10.20944/preprints201808.0343.v1

Globalization Effects on the Reports of Non-Endemic Parasitosis in Italy

Giorgia Bracaglia, Livia Mancinelli, Stefania Ranno, Federica Del Chierico, Hyppolite K. Tchidjou, Ottavia Porzio, Andrea Onetti Muda, Lorenza Putignani

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: international adoptions; asymptomatic and misidentified parasitosis; intestinal parasite infections, IPIs; Giardia lamblia; Trichuris spp.; Strongyloides stercoralis; IPIs screening guidelines

Online: 19 August 2018 (05:30:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0304.v1

When Control Exacerbates Distress: A Qualitative Study Exploring the Experiences of Hong Kong Chinese Parents in Caring for a Child with Asthma

Yuen-yu Chong, Doris Leung, Yim-wah Mak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: parents; children; asthma; qualitative research; psychological distress; psychological adjustment

Online: 22 May 2018 (12:21:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201811.0435.v1

Assessment of Left Ventricular Diastolic Function in Children Undegoing Hemodialysis Using Various Doppler Techniques

Ljiljana Sulovic, Vladimir Sulovic, Zorica Zivkovic, Jovan Zivkovic, Maja Vasic, Nenad Sulovic

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: chronic kidney disease; hemodialysis; cardiovascular disease; echocardiography; child

Online: 19 November 2018 (09:22:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0435.v1

Pediatric Inflammatory Multisystem Syndrome (PIMS) Did Occur in Poland during Months with Low COVID-19 Prevalence. Preliminary Results of a Nationwide Register.

Magdalena Okarska-Napierała, Kamila Ludwikowska, Leszek Szenborn, Natalia Dudek, Anna Mania, Piotr Buda, Janusz Książyk, Katarzyna Mazur-Malewska, Magdalena Figlerowicz, Maciej Szczukocki, Beata Kucińska, Bożena Werner, Lidia Stopyra, Agnieszka Czech, Elżbieta Berdej-Szczot, Aneta Gawlik, Paulina Opalińska, Artur Mazur, Danuta Januszkiewicz-Lewandowska, Cezary Niszczota, Teresa Jackowska, Jacek Wysocki, Paweł Tracewski, Jacek Kusa, Paulina Potocka, Artur Sulik, Katarzyna Ziora, Helena Krakowczyk, Aleksandra Wodniak, Janusz Zaryczański, Alicja Żakiewicz-Cepak, Elżbieta Jarocka-Cyrta, Agnieszka Koczwara, Anna Prusek-Dudkiewicz, Ewa Zbucka-Jachowska, Sabina Langer-Wójcik, Elżbieta Kołodziej, Ernest Kuchar

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: PIMS; MIS-C; SARS-CoV-2; COVID-19; Kawasaki disease; survey

Online: 18 September 2020 (11:29:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0093.v1

Identification of Research Priorities in Infertility and Assisted Reproduction: An International, Multicenter Study in Partnership with Patients

D García, F Lindenberg, E Toft, A La Marca, R Borrás, AR Lorenzon, MB Chehin, L Silva, ELA Motta, M Ripero, j Madero, RM Marinho, CA Oliveira, JPJ Caetano, A Bolívar, S Brazal, A Rodríguez, R Vassena

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Patients involvement; research interests; ART treatments; treatment personalization; psychological effects; healthy habits; fertility protection; infertility prevention; lifestyle; diet

Online: 8 April 2019 (12:46:17 CEST)

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STUDY QUESTION: Which are the main research interests among patients of assisted reproductive technologies (ART)? SUMMARY ANSWER: Patients identified as research priorities that deserve further investigation: success rates and risks of ART, side-effects of treatments, resources to cope with infertility, effectiveness of alternative therapies, lifestyle habits to protect fertility, oocyte quality and ovarian reserve, and causes of genetic or hereditary infertility. WHAT IS KNOWN ALREADY: The involvement of patients and caregivers in setting research agendas in medicine has gathered significant momentum in the last decade. Patients’ involvement in setting research priorities offers several benefits: improved patient knowledge and awareness of their condition; greater understanding of the medical professionals of the impact of the condition on patients’ quality of life; reduced costs associated with redundant research activities. This is may be also applicable to research in infertility and ART, where patients’ interests have never been explored before. STUDY DESIGN, SIZE, DURATION: This is a cross-sectional study that consists of an anonymous online survey, which was sent up to three times to 2112 patients from 11 fertility centers in 5 countries between January-December 2018. The study design was based on the James Lind Alliance priority setting partnership model, which comprises the identification of patients groups, the exploration of the research agenda, the analysis of collected data and identification of priorities. PARTICIPANTS/MATERIALS, SETTING, METHODS: Overall, 2112 patients were contacted, and 945 surveys were answered (RR: 44.7%). Patients were asked to identify research questions relevant to them in the areas of infertility causes and prevention, fertility treatments (medication and ART), and the emotional aspects of infertility. Answers were categorized in topics and ranked by frequency. A long list of the top-30 research topics was extracted from the aggregate results, from which, a short list of the top-10 research topics was created. At the end, 10 research questions related to each of the 10 research topics were constructed, based on the answers given by patients. MAIN RESULTS AND THE ROLE OF CHANCE: Female (845, 89.4%) and male (100, 10.6%) patients were included. The mean age of patients was 37.8 (SD 1.74). Most of the patients did not have children at the time of the survey (523, 59%), while 51 (5.7%) were pregnant. Sixty (6.3%) patients did not start treatment, 579 (61.3%) were performing a treatment with their own gametes and 304 (32.2%) were treated through gamete donation. Patients were mainly interested in the effectiveness of ART -especially per clinical profile-, side effects of drugs, protection of fertility and prevention of infertility –especially through diet and exercise-, and psychological aspects of the infertility journey. The top-10 research questions (and weight) obtained were: 1) What are the side-effects of ART treatments? (41.6%); 2) What are the most effective methods to cope with infertility from the psychological point of view? (37.2%); 3) What effects could diet have on fertility? (25.9%); 4) What are ART success rates per clinical profile? (25.9%); 5) Are there habits and lifestyle factors that could prevent infertility? (20.0%); 6) What are the long-term risks associated to ART? (18.5%); 7) Are alternative therapies such as acupuncture, yoga, and meditation effective to treat/prevent infertility? (18.5%); 8) What is the impact of exercise on fertility? (15.4%); 9) How does oocytes quantity and quality affect fertility? (9.5%); 10) What are the genetic patterns or hereditary conditions causing/related to infertility? (9.5%). LIMITATIONS, REASONS FOR CAUTION: Although all respondents had attended a fertility center, not all of them were diagnosed as infertile (i.e. single women) and had started treatment at the time of response, while a few were pregnant; their priorities for research might have been influenced by their infertility journey. Also, all participants attended private fertility centers: areas of interest may be different in public settings. WIDER IMPLICATIONS FOR THE FINDINGS: Researchers and clinicians should keep in mind that, in addition to improvement of treatments’ success rates and side-effects, patients greatly value research on causes, prevention and emotional aspects of infertility. As their views might differ from those of medical professionals, patients’ voices should be incorporated in setting infertility research priorities.

Preprint ARTICLE | doi:10.20944/preprints202205.0011.v1

Tanning Bed Legislation for Minors: A Comprehensive International Comparison

Katharina Diehl, Karla S. Lindwedel, Sonja Mathes, Tatiana Görig, Olaf Gefeller

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: tanning bed; sunbed; legislation; ban; adolescent; minors; ultraviolet radiation

Online: 4 May 2022 (13:19:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201806.0129.v1

In Search of Factors Negatively Affecting Vaccine Immunity to Pertussis in Preschool Children Before the Administration of the First Booster

Anna Bednarek, Anna Bodajko-Grochowska, Barbara Hasiec, Robert Klepacz, Katarzyna Szczekala, Danuta Zarzycka, Andrzej Emeryk

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: negatively factors; pertussis; preschool children; vaccine immunity

Online: 8 June 2018 (11:28:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0315.v1

Succinic Semialdehyde Dehydrogenase Deficiency: An Update

Miroslava Didiášová, Antje Banning, Heiko Brennenstuhl, Sabine Jung-Klawitter, Claudio Cinquemani, Thomas Opladen, Ritva Tikkanen

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: succinic semialdehyde dehydrogenase deficiency; gamma-amino butyric acid; organic acidurias; enzyme replacement therapy; pharmacological chaperones; clinical trials; autophagy

Online: 26 January 2020 (08:10:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0225.v2

COVID-19: Considerations for Children and Adolescents with Diabetes

Devi Dayal

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Coronavirus disease 2019; COVID-19; children; diabetes; type 1 diabetes; type 2 diabetes; recommendations

Online: 15 May 2020 (04:54:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201906.0261.v1

Diagnostic Imaging in Pediatric Chronic Rhinosinusitis: A Guide for Clinicians

Giorgio Conte, Luca Caschera, Sandro Magnani, Claudia Cinnante, Fabio Maria Triulzi, Lorenzo Pignataro, Sara Torretta

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: rhinosinusitis; pediatric chronic rhinosinusitis; computed tomography; magnetic resonance imaging

Online: 26 June 2019 (07:21:24 CEST)

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Preprint REVIEW | doi:10.20944/preprints202301.0139.v1

Recent Trends in Antisense Therapies for Duchenne muscular dystrophy

Harry Wilton-Clark, Toshifumi Yokota

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: eteplirsen; golodirsen; viltolarsen; casimersen; WVE-N531; SRP-5051; DS-5141B; NS-089/NCNP-02; SCAAV9.U7.ACCA; ATL1102

Online: 9 January 2023 (04:18:24 CET)

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Preprint BRIEF REPORT | doi:10.20944/preprints202007.0633.v1

Community-Based Household Survey to Identify Disability Burden and Health-Related Quality of Life Following Road Traffic Accidents in Ujjain, India

Aditya Mathur, Love Mehra, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Children; adolescents; post-road traffic accidents; EQ-5D-5L; disability burden; health-related quality of life

Online: 26 July 2020 (03:11:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0048.v1

Vitamin D and ω-3 Supplementations in Mediterranean Diet During the 1st Year of Overt Type 1 Diabetes: A Cohort Study

Francesco Cadario, Erica Pozzi, Stefano Rizzollo, Marta Stracuzzi, Sheila Beux, Alberto Giorgis, Deborah Carrera, Fabiola Fullin, Sergio Riso, Angela Maria Rizzo, Gigliola Montorfano, Marco Bagnati, Umberto Dianzani, Philippe Caimmi, Gianni Bona, Camillo Ricordi

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: cholecalciferol; omega3; EPA; DHA; arachidonic acid; AA/EPA ratio; type 1 diabetes; remission period; honeymoon period

Online: 3 July 2019 (08:10:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202204.0014.v1

Prevalence and Determinants of Excessive Screen Viewing Time in Children and its Effects on Physical Activity, Sleep, Eye Symptoms and Headache

Shilpa Jain, Shreya Shrivastava, Aditya Mathur, Deepali Pathak, Ashish Pathak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: screen view time; children; risk factors; India

Online: 4 April 2022 (10:57:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202007.0718.v1

Effect of Lactate and Lactate Clearance Condition on the Prognosis of Sepsis in Children

D M Kamrul Hasan, Shafayat Hossain Evan, Md Rezaul Karim, Xin Yi Men, Zhang Huifeng, Chen Yuan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Sepsis, Septic shock, Lactic acid, Dynamic monitoring, Prognosis

Online: 30 July 2020 (11:23:48 CEST)

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Objectives: To investigate the value of early lactate dynamic monitoring index in predicting prognosis of patients with sepsis and septic shock. Methods: We performed our test on 50 patients. Out of 50 patients, 28 are male, and 22 are female. Prospectively studied pediatric patients with septic shock were performed. Vital signs, Lactate clearance, were obtained at presentation 6 h, 12 h, 24 h over the first 48 h of hospitalization. The therapy received, outcome parameters of mortality and duration of hospitalization were recorded. Results: The statistical data and comparative analysis showed that an average of 16.88 days after admission, 5 patients have died, 17 patients are poorly prognosis leaves the hospital, and the remaining 28 are recovered and discharged. The primary outcome variable of mean 16 days hospitalization mortality rate was 10%. Poor prognosis 34% and fully recovery 56 % were observed. In this retrospective cohort study, a lactate level of more than 2.5mmol/L was the best threshold to predict 28-day mortality among severe sepsis and septic shock patients. In our research, we found mean LC 6 h 3.08mmol/L, and after 48 h mean it is 1.79mmol/L. Significant LC 6 h found, which is 8.08mmol/L in the death group patient where 48 h mmol/L shows significant high. Poor prognosis also presents a clinical increase of lactate level high in the LC 6 h analysis, which is 3.32mmol/L. Recovered patients showed a significant improvement after administering treatment depending on the patient organ involvement and good decrease of lactate reports achieved, which is 1.20mmol/L, where admission reports show it was 1.91mmol/L in LC 6 h. Mean Heart rate 94/51mmhg, pulse 119, temperature 39℃, respiratory rate 32.26, and urine output 456 ml recorded during our study. Death patient shows a remarkable detonation of those reports but has a significant clinical report with the recovered patients. Conclusion: The early lactate dynamic monitoring index has a high value in predicting sepsis and septic shock patients' prognosis, thus worth popularizing.

Preprint CASE REPORT | doi:10.20944/preprints202002.0252.v1

Thrombocytosis in an Infant with a TRPV4 Mutation: A Case Report

Christopher S. Thom, Erik Brandsma, Michele P. Lambert

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: thrombocytosis; skeletal dysplasia; TRPV4; calcium channel

Online: 18 February 2020 (02:47:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints202112.0312.v1

Factors Affecting the Knowledge and Motivation of Health Cadres on Stunting Prevention in Children in Indonesia

Henny Suzana Mediani, Sri Hendrawati, Tuti Pahria, Ati Surya Mediawati, Mira Suryani

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Health cadres; knowledge; motivation; stunting children; stunting prevention

Online: 20 December 2021 (12:40:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0185.v1

The Use of Dietary Interventions in Pediatric Patients

Shirin Madzhidova, Lusine Sedrakyan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: pediatric pharmacy; complementary alternative medicine; dietary interventions; oral manifestations; chronic pediatric conditions; ketogenic diet; gluten free casein free diet

Online: 8 November 2018 (03:55:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0305.v2

Improvement of Sickle Cell Disease Morbi-Mortality in Children: Experience Gained in a Remote Area of an African Country

Benoît Mukinayi Mbiya, Didier Kalenda Kalombo, Yannick Nkesu Mukendi, Valery Daubie, John Kalenda Mpoyi, Parola Mukendi Biboyi, Ghislain Tumba Disashi, Béatrice Gulbis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: sickle cell disease; feasibility; regular follow-up; remote area; Democratic Republic of Congo

Online: 22 September 2020 (08:12:05 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0073.v1

Genetics and Genomics of Pediatric Pulmonary Arterial Hypertension

Carrie L. Welch, Wendy K. Chung

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: genomics; pediatrics; lung disease; pulmonary arterial hypertension

Online: 3 September 2020 (15:29:36 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0366.v1

The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?

Melissa Rioux, Mara McNeil, Magen Francis, Nicholas Dawe, Mary Foley, Joanne Langley, Alyson Kelvin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: vaccine; age; pneumonia; influenza virus; seasonal influenza; influenza imprinting; infant; infant immunity; immune response

Online: 17 August 2020 (12:04:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0187.v1

Clinical Characteristics for Differentiating Febrile Children with Suspected Kawasaki Disease Diagnosis

Jia-Huei Yan, Ling-Sai Chang, Yi-Ju Lin, Mindy Ming-Huey Guo, Ying-Hsien Huang, Ho-Chang Kuo

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: clinical characteristics; febrile children; Kawasaki disease

Online: 20 February 2019 (09:10:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201808.0129.v1

First Aid Practices and Health Seeking Of Caregivers for Unintentional Childhood Injuries in Ujjain, India: A Community Based Cross-Sectional Study

Ashish Pathak, Nitin Agrawal, Love Mehra, Aditya Mathur, Vishal Diwan

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: unintentional childhood injuries; first aid; health seeking, community survey injuries; India

Online: 6 August 2018 (16:25:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0678.v1

Unstructured Text in EMR Improves Prediction of Death after Surgery in Children

Oguz Akbilgic, Ramin Homayouni, Kevin Heinrich, Max Raymond langham, Jr, Robert Lowell Davis

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: post-operative death; unstructured data; logistic regression; text mining; surgery outcome

Online: 29 October 2018 (11:46:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0314.v1

Demographic, Laboratory and Clinical Comparison of Pediatric Brucella Cases with and without Liver Involvement

Mehmet Agin, Yusuf Kayar

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: brucellosis; elevated liver enzymes; hepatomegaly; children

Online: 29 August 2019 (17:22:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202207.0447.v1

Impact of COVID-19 Pandemic on School-aged Children’s Physical Activity, Screen Time and Sleep in Hong Kong: a Cross-sectional Repeated Measures Study

Hung-Kwan So, Gilbert T Chua, Ka-Man Yip, Keith TS Tung, Rosa S Wong, Lobo HT Louie, Winnie WY Tso, Ian Wong, Jason Yam, Mike Kwan, Gary KK Lau, Judy Kong, Wilfred HS Wong, Patrick Ip

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: COVID-19 pandemic; school closures; school-aged children; physical activity; screen time; sleep; Hong Kong

Online: 29 July 2022 (03:57:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0706.v1

Infant Food Security in New Zealand: A Multidimensional Index Developed from Cohort Data

Deborah Schlichting, Ladan Hashemi, Cameron Grant

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: food security; paediatrics; cohort study; New Zealand; developed country

Online: 30 October 2018 (05:29:12 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0055.v1

Can Fetuin-A Level, CRP, and WBC be a Predictive Value in the Diagnosis of Acute Appendicitis in Children with Abdominal Pain?

Abuzer Coskun, Cengiz Güney

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: emergency department; pediatric acute appendicitis; perforatio; fetuin-A level

Online: 5 August 2019 (08:00:41 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201907.0002.v1

Diagnostic and Prognostic Value of Transcranial Magnetic Stimulation in Mucopolysaccharidosis-Related Cervical Myelopathy

Mariagiovanna Cantone, Giuseppe Lanza, Alice Le Pira, Rita Barone, Giovanni Pennisi, Rita Bella, Manuela Pennisi, Agata Fiumara

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: motor evoked potentials lysosomal disorders; cortical-spinal tract; spinal cord compression; cervical myelopathy; clinical neurophysiology

Online: 1 July 2019 (11:05:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0114.v1

Epilepsy in Children: From Diagnosis to Treatment

Carmelo Minardi, Roberta Minacapelli, Pietro Valastro, Francesco Vasile, Sofia Pitino, Piero Pavone, Marinella Astuto, Paolo Murabito

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: seizures; status epilepticus; children

Online: 6 October 2018 (11:38:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0210.v1

Pertussis Immunisation in Pregnancy Safety (PIPS) Study: A Retrospective Cohort Study of Safety Outcomes in Infants Exposed to Tdap Vaccine in Utero

Helen A. Petousis-Harris, Yannan Jiang, Lennox Yu, Donna Watson, Tony Walls, Nikki Turner, Anna Howe, Jennifer Griffin

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: post-marketing surveillance; vaccine safety; pertussis; Tdap; pregnancy; infant

Online: 18 July 2019 (09:26:02 CEST)

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Working Paper ARTICLE

The Shape of Anterior-Posterior Spinal Curvatures and Body Composition in School-Children

Jacek Wilczyński, Magdalena Lipińska-Stańczak

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: body posture defects; the shape of anterior-posterior spinal curvatures; body composition; school-children

Online: 11 April 2020 (05:38:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0219.v1

Intragenic Duplication of DMRT1 in a SRY-Negative Boy with 46,XX Disorder of Sex Development

Veronica Bertini, Fulvia Baldinotti, Nina Tyutyusheva, Camillo Rosano, Cinzia Cosini, Adelaide Maria Caligo, Diego Peroni, Angelo Valetto, Silvano Bertelloni

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 46,XX disorder of sex development; SRY-negative male; Testis determination; DMRT1; DMRT1 duplication

Online: 14 December 2021 (07:58:55 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201810.0169.v2

A Rare Pediatric Case of Severe Bird Fancier's Hypersensitivity Pneumonitis Presented with Viral Pneumonitis-Like Picture

Basel Habra, Atqah AbdulWahab

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: bird fancier’s lung (BFL); hypersensitivity pneumonitis (HP); child; pulse steroid

Online: 11 October 2018 (05:08:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202011.0224.v2

Excessive Use of Paracetamol (Acetaminophen) during Early Development and Difficulties in Retrospective Analyses of Risks

Dillan Bono-Lunn, Maragatha Kuchibhatla, Antara Palkar, Jasmine Cendejas-Hernandez, Joshua T. Sarafian, Victoria G. Lawton, Lauren G. Anderson, John P. Jones III, William Parker

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: acetaminophen; paracetamol; autism; pediatrics; safety

Online: 30 March 2022 (05:47:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202304.0652.v1

Chromosome 22q11.2 Deletion Syndrome: A Comprehensive Review of Molecular Genetics in the Context of Multidisciplinary Cinical Approach

Aleksandra Szczawińska-Popłonyk, Eyal Schwartzmann, Zuzanna Chmara, Antonina Głukowska, Tomasz Krysa, Maksymilian Majchrzycki, Maurycy Olejnicki, Paulina Ostrowska, Joanna Babik

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: 22q11.2 deletion; microdeletion; DiGeorge syndrome; velocardiofacial syndrome; dysmorphism; inborn errors of immunity; thymus; congenital heart defect; hypocalcemia

Online: 20 April 2023 (10:41:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints202306.2262.v1

Water in the Belly- a Review of Current Knowledge About Ascites in Children

Aleksandra Kamińska, Katarzyna Plata-Nazar, Julia Leszkowicz

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: ascites; liver failure; portal hypertension

Online: 30 June 2023 (13:40:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202303.0027.v1

Assessing Adverse Childhood Experiences in Young Refugees: A Systematic Review of Available Questionnaires

Shaymaa Abdelhamid, Eline Kraaijenvanger, Joachim Fischer, Maria Steinisch

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: Adverse Childhood Experiences (ACEs); Refugee children; Systematic review; Questionnaires

Online: 2 March 2023 (01:42:19 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201808.0437.v1

Teicoplanin-Induced Anaphylactic Reaction in Children: a Case Report

Godwin Oligbu, Leila Ahmed

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: teicoplanin, anaphylaxis, children

Online: 24 August 2018 (14:22:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202112.0093.v1

To Mask or Not to Mask - Evaluation of Cognitive Performance in Children Wearing Face Masks during School Lessons (Maskids)

Anne Schlegtendal, Lynn Eitner, Michael Falkenstein, Anna Hoffmann, Thomas Lücke, Kathrin Sinningen, Folke Brinkmann

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: children; face masks; school; cognitive impairment; concentration

Online: 6 December 2021 (17:31:38 CET)

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Preprint ARTICLE | doi:10.20944/preprints201811.0435.v2

Assessment of Left Ventricular Diastolic Function in Children Undegoing Hemodialysis. A Mini Review

Ljiljana Sulovic, Vladimir Sulovic, Zorica Zivkovic, Maja Vasic, Nenad Sulovic

Subject: Medicine And Pharmacology, Pediatrics, Perinatology And Child Health Keywords: chronic kidney disease; hemodialysis; cardiovascular disease; echocardiography; child

Online: 4 July 2019 (10:37:00 CEST)

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Medicine and Pharmacology