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Preprint REVIEW | doi:10.20944/preprints201701.0094.v1

Theranostics in Nuclear Medicine Practice

Anna Yordanova, Elisabeth Eppard, Stefan Kürpig, Stefan Schönberger, Maria Gonzalez-Carmona, Georg Feldmann, Hojjat Ahmadzadehfar, Markus Essler

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: theranostics; nuclear medicine; personalized medicine

Online: 22 January 2017 (04:29:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0456.v1

High-efficiency Non-viral Transfection of Human Primary T Lymphocytes

Hossein Khanahmad, Ilnaz Rahimmanesh, Mehdi Totonchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Human primary T cells; Cancer immunotherapy; Gene delivery; Protamine sulfate; Transfection

Online: 28 May 2020 (11:33:47 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0091.v1

Screening for Selective Anticancer Activity of Plants from Grazalema Natural Park, Spain

José Manuel Calderón-Montaño, Sara María Martínez-Sánchez, Estefanía Burgos-Morón, Emilio Guillén-Mancina, Julio José Jiménez-Alonso, Felipe García, Abelardo Aparicio, Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; lung cancer; leukemia; Daphne; Thapsia; daphnane diterpenes

Online: 13 February 2018 (07:08:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201707.0074.v1

The Stem Cell Division Theory of Cancer

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer etiology; carcinogenesis; cancer prevention; stem cells; cancer stem cells; stem cell environment; cells of origin in cancer; somatic mutation theory of cancer

Online: 26 July 2017 (08:42:41 CEST)

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All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and this cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the disease and has important implications for cancer prevention and therapy.

Preprint ARTICLE | doi:10.20944/preprints201609.0074.v1

Regulation of ERK and AKT Pathways by Hepatitis B Virus X Protein via Notch1 Pathway in Hepatocellular Carcinoma

Bo Liao, Hong-Hao Zhou, Hui-Fang Liang, Chang-Hai Li

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: hepatocellular carcinoma; hepatitis B virus X protein; Notch1 pathway; ERK; AKT

Online: 21 September 2016 (09:49:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0093.v1

Efficacy and Safety of Eribulin in Taxane-Refractory Patients in the “Real World”

Vito Lorusso, Saverio Cinieri, Agnese Latorre, Luca Porcu, Lucia Del Mastro, Fabio Puglisi, Sandro Barni

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: metastatic breast cancer; taxanes; eribulin; observational study

Online: 26 September 2016 (11:39:32 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0052.v1

Oral Mucositis: Melatonin Gel an Effective New Treatment

Ahmed E Abdel-Moneim, Ana Guerra-Librero, Javier Florido, Ying-Qiang Shen, Beatriz Fernández-Gil, Darío Acuña-Castroviejo, Germaine Escames

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mucositis; radiotherapy; chemotherapy; pathophysiology; management; melatonin

Online: 9 March 2017 (04:46:30 CET)

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Preprint REVIEW | doi:10.20944/preprints201902.0043.v1

HER2 Directed Antibody-Drug-Conjugates beyond T-DM1 in Breast Cancer

Gabriel Rinnerthaler, Simon Peter Gampenrieder, Richard Greil

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: ADC; HM2-MMAE; (vic-)trastuzumab duocarmazine; Trastuzumab deruxtecan; TAK-522; Trastuzumab emtansine; anti-HER2/PBD-MA; HER2 low; HER2-low; mode of action

Online: 4 February 2019 (17:01:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0165.v2

Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats

Anna Kakehashi, Midori Yoshida, Yoshiyuki Tago, Naomi Ishii, Takahiro Okuno, Min Gi, Hideki Wanibuchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pueraria mirifica; mammary gland; uterus; carcinogenesis; estrogenic activity; Donryu rat

Online: 26 September 2016 (09:25:39 CEST)

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Preprint EDITORIAL | doi:10.20944/preprints201608.0130.v1

What Is the Main Cause of Cancer?

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: carcinogenesis; cancer; age distribution of cancer

Online: 11 August 2016 (11:40:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202205.0092.v1

Fluctuation of Serum CEA in the Conventional Normal Range and The Risk of Relapse Following Curative Intent Treatment of Colorectal Cancer

Zsolt Fekete, Patricia Suteu, Laura Gligor, Nicolae Todor, Alina-Simona Muntean, Alexandra Gherman, Dan Eniu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CEA 1; colorectal cancer 2; follow-up 3; tumor markers 4; early intervention 5; adjuvant chemotherapy 6

Online: 7 May 2022 (04:09:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0016.v1

Human Caveolin-1 a Potent Inhibitor for Prostate Cancer Therapy: A Computational Approach

Uzma Khanam, Pallavi Somvanshi, Shafiul Haque, Balwant Kishan Malik, Bhawna Rathi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: molecular dynamics simulation; virtual screening; molecular docking; prostate cancer; caveolin-1

Online: 7 October 2016 (12:09:06 CEST)

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Preprint ESSAY | doi:10.20944/preprints201608.0158.v1

A Local Mechanism by which Alcohol Consumption Causes Cancer

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: alcohol; cancer; ethanol; tobacco; carcinogenesis; oral cavity; pharynx; esophagus; stem cells; stem cell division theory of cancer

Online: 16 August 2016 (09:45:33 CEST)

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Epidemiological data indicate that 5.8% of cancer deaths world-wide are attributable to alcohol consumption. The risk of cancer is higher in tissues in closest contact on ingestion of alcohol, such as the oral cavity, pharynx and esophagus. The risk of these cancers is increased even in people who have only one alcoholic drink per day. However, since ethanol is not mutagenic and the carcinogenic metabolite of ethanol (acetaldehyde) is mostly produced in the liver, it is not clear why alcohol use preferentially exerts a local carcinogenic effect. It is well known that ethanol causes cell death at the concentrations present in alcoholic beverages; however, this effect has been overlooked probably because dead cells cannot give rise to cancer. Here I discuss that the cytotoxic effect of ethanol on the cells lining the oral cavity, pharynx and esophagus activates the division of the stem cells located in deeper layers of the mucosa to replace the dead cells. Every time stem cells divide, they become exposed to unavoidable errors associated with cell division (e.g., mutations arising during DNA replication and chromosomal alterations occurring during mitosis) and also become highly vulnerable to the genotoxic activity of endogenous and exogenous DNA-damaging agents (e.g., reactive oxygen species, acetaldehyde and tobacco carcinogens). Alcohol consumption probably increases the risk of developing cancer of the oral cavity, pharynx and esophagus by promoting the accumulation of cell divisions in the stem cells that maintain these tissues in homeostasis. Because the cytotoxic activity of ethanol is concentration-dependent, the risk of these cancers will not only increase with increasing amounts of ethanol, but also with increasing concentrations; an ounce of whisky is probably more carcinogenic when taken undiluted than when taken mixed with non-alcoholic beverages. The local cytotoxic effect of ethanol can also explain the known synergistic effect of alcohol and tobacco use on the risk of these cancers. Understanding the mechanisms of carcinogenicity of alcohol is important to reinforce the epidemiological evidence and to raise public awareness of the strong link between alcohol consumption and cancer.

Preprint ARTICLE | doi:10.20944/preprints201608.0188.v1

The Apoptosis Induction of Oleandrin on Osteosarcoma Cells through Regulating Mitochondrial- and Death Receptor-Dependent Apoptotic Pathways in Vitro

Yunlong Ma, Bin Zhu, Lei Yong, Chunyu Song, Xiao Liu, Huilei Yu, Peng Wang, Zhongjun Liu, Xiaoguang Liu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oleandrin; osteosarcoma; apoptosis; caspases

Online: 22 August 2016 (05:35:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints201610.0100.v1

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

Yasushi Taniguchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: BET; bromodomain; histone acetylation; gene transcription; BET inhibitor

Online: 24 October 2016 (05:06:56 CEST)

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Preprint COMMENTARY | doi:10.20944/preprints201608.0187.v1

A Plausible Biological Mechanism by which Extremely Low-Frequency Electromagnetic Fields Increase the Risk of Childhood Leukemia

Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: magnetic fields; power lines; cancer; carcinogenesis; stem cell division theory of cancer

Online: 22 August 2016 (05:15:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0105.v1

Comparison of Two EpCAM-Based Methods for CTC Detection and Molecular Characterization in Advanced Colorectal Cancer

Santiago Cabezas-Camarero, Virginia De La Orden, Silvia Veganzones-De-Castro, Beatriz Medievo-Valeros, Manuel Enrique Fuentes-Ferrer, Antonio Sánchez-Ruiz, Mariano Provencio, Enrique Aranda, Javier Sastre, Eduardo Díaz-Rubio

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: circulating tumor cells; CTC, liquid biopsy; KRAS; colorectal cancer; EpCAM; CellSearch; IsoFlux; castPCR; intratumor heterogeneity

Online: 21 November 2016 (09:52:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0030.v1

Differences in the Bacteriome of Smokeless Tobacco Products with Different Oral Carcinogenicity: Compositional and Predicted Functional Analysis

Nezar Noor Al-hebshi, Fahd Ali Alharbi, Mohammed Mahri, Tsute Chen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bacteria; bacteriome; carcinoma; microbiome; mouth; smokeless; snuff; tobacco

Online: 6 March 2017 (07:18:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201701.0098.v1

Induction of G2M Arrest by Flavokawain A, A Kava Chalcone, Increases the Responsiveness of HER2 Overexpressing Breast Cancer Cells to Herceptin

Danielle D. Jandial, Lauren S. Krill, Lixia Chen, Chunli Wu, Yu Ke, Jun Xie, Bang H. Hoang, Xiaolin Zi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Flavokawain A; HER2 overexpression; resistance to apoptosis

Online: 23 January 2017 (03:30:01 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0139.v1

Cancer: A Turbulence Problem

Abicumaran Uthamacumaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer; Turbulence; Navier-Stokes; Chaos; Complexity; Fractals; Fluid Dynamics; Reprogramming

Online: 14 February 2019 (14:04:51 CET)

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Preprint ARTICLE | doi:10.20944/preprints201906.0288.v1

Cancer: Strange Attractors and Complexity

Abicumaran Uthamacumaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancer; Turbulence; Complexity; Machine Learning; Chaos; Reprogramming

Online: 27 June 2019 (11:36:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0165.v1

Pueraria mirifica Exerts Estrogenic Effect and Promotes Mammary and Endometrial

Anna Kakehashi, Midori Yoshida, Yoshiyuki Tago, Naomi Ishii, Min Gi, Hideki Wanibuchi

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pueraria mirifica; mammary gland; uterus; carcinogenesis; estrogenic activity; Donryu rat

Online: 17 August 2016 (11:57:56 CEST)

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Preprint REVIEW | doi:10.20944/preprints202008.0528.v1

Canine Hemangiosarcoma: A Certainly Less Than Ideal, Very Ugly Cancer

Ashley Tinsley

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Hemangiosarcoma; neoplasia; oncology; metastasis; doxorubicin; hemoabdomen

Online: 24 August 2020 (10:08:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0028.v1

Predictors of Survival in Children with Ependymoma from a Single Center: Using Random Survival Forests

Francisco H. C. Felix, Juvenia B. Fontenele

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: random survival forests; ependymoma; predictors; valproic acid

Online: 3 November 2016 (11:02:12 CET)

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Preprint REVIEW | doi:10.20944/preprints201608.0115.v2

Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment

Rudolph E. Willis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oncogenes; oncogene addiction; carcinogenesis; transcription factor; cancer genome; gene fusion; cancer genetics; cancer stem cell; targeted cancer therapy; personalized medicine

Online: 14 September 2016 (08:30:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201612.0107.v1

Evidence for the Involvement of Toll-Like Receptor 4 (TLR4)-Mediated Apoptosis in Gynecological Cancers

Jinyoung Won, Youngjeon Lee, Kyu-Tae Chang, Yonggeun Hong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: apoptosis; gynecologic cancer; lipopolysaccharide; proliferation; Toll-like receptor

Online: 20 December 2016 (11:12:07 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0098.v1

Adenovirus with DNA Packaging Gene Mutations Increased Virus Release

Stephen L. Wechman, Xiao-Mei Rao, Kelly M. McMasters, Heshan Sam Zhou

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung cancer; adenovirus; E1b; UV-irradiation; genomics

Online: 19 December 2016 (09:33:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints201708.0023.v1

CBFA2T2 is Associated with a Cancer Stem Cell State in Renal Cell Carcinoma

Du-Chu Chen, You-de Liang, Yi-Ze Wang, Chun-Zhi Ai, Xin-Xing Zhu, Ya-Wei Yan, yasmeen saeed, Bin Yu, Jingying huang, Yuxin Gao, Jiaqi Liu, Yi-zhou jiang, Min Liu, Demeng Chen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CBFA2T2; renal cell carcinoma; cancer stem cells; OCT-4; NANOG

Online: 7 August 2017 (15:22:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints201612.0113.v1

Breast Cancer Brain Metastases: Clonal Evolution in Clinical Context

Jodi M. Saunus, Amy E. McCart Reed, Zhun Leong Lim, Sunil R. Lakhani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; brain metastases; clonal evolution; precision medicine; genomics; tumour microenvironment

Online: 22 December 2016 (09:57:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0080.v1

Detecting Breast Cancer with a Dual-Modality Device

Kamila Padia, Tania S. Douglas, Lydia L. Cairncross, Roland V. Baasch, Christopher L. Vaughan

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; dense breasts; dual-modality imaging; FFDM; ABUS

Online: 14 March 2017 (09:24:58 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0216.v1

A Dysbiotic Mycobiome Dominated by Candida albicans is Identified within Oral Squamous Cell Carcinomas

Manosha Perera, Nezar Noor Al-hebshi, Irosha Perera, Deepak Ipe, Glen Ulett, David J. Speicher, Tsute Chen, Newell W. Johnson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 18S rRNA; fungi; mycobiome; carcinoma; High-Throughput Nucleotide Sequencing; microbiome; mouth; squamous cell

Online: 30 March 2017 (05:37:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints201811.0525.v1

CAR T-Cell Immunotherapy in Human and Veterinary Oncology: Changing the Odds against Hematological Malignancies

Jonathan P Mochel, Stephen C Ekker, Chad M Johannes, Albert E Jergens, Karin Allenspach, Agnes Bourgois-Mochel, Michael Knouse, Sebastien Benzekry, Wesley Wierson, Amy K LeBlanc, Saad S Kenderian

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: immuno-oncology; CAR T-cell; lymphoma; one health

Online: 21 November 2018 (11:34:58 CET)

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Preprint REVIEW | doi:10.20944/preprints201801.0167.v1

Molecular imaging modalities using nanoprobes for cancer diagnosis

Daryoush Shahbazi-Gahrouei, Pegah Moradi Khaniabadi, Bita Moradi khaniabadi, Saghar Shahbazi-Gahrouei, Mona Fazel

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: molecular imaging; nanoparticles; cancer diagnosis; imaging modalities

Online: 18 January 2018 (05:12:13 CET)

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Preprint REVIEW | doi:10.20944/preprints202202.0052.v1

New Targeted Therapies and Combinations of Treatments for Cervical, Endometrial and Ovarian Cancers: A Year in Review

Adelina Silvana Dragomir, Elena Adriana Dumitrescu, Isabela Anda Komporaly, Raluca Ioana Mihăilă, Cristian Virgil Lungulescu, Dana Lucia Stănculeanu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cervical cancer; endometrial cancer; ovarian cancer; 2021 update; novel targeted therapies; immunotherapy

Online: 3 February 2022 (13:02:11 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0024.v1

Inflammatory Bacteriome Featuring Fusobacterium nucleatum and Pseudomonas aeruginosa Identified in Association with Oral Squamous Cell Carcinoma

Nezar Noor Al-hebshi, Akram Thabet Nasher, Mohamed Yousef Maryoud, Husham E. Homeida, Tsute Chen, Ali Mohamed Idris, Newell W. Johnson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: 16S rRNA; bacteria; bacteriome; carcinoma; High-Throughput Nucleotide Sequencing; microbiome; mouth; squamous cell

Online: 6 March 2017 (04:47:15 CET)

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Preprint REVIEW | doi:10.20944/preprints202104.0517.v1

Overview of Adverse Events Associated With Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy

Ekaterina Vorozheikina, Magdalena Ruiz, Maria Leticia Solari, Dmitry Ostasevich, Luis Mendoza

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: CAR T-cells; chimeric antigen receptor T cells; cytokine release syndrome; central nervous system toxicity; neurotoxicity; adverse events; pathophysiology

Online: 19 April 2021 (21:17:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints201702.0098.v1

MicroRNAs in the Communication between Cancer Associated Fibroblasts (CAF) and Cancer Cells

Maren Schoepp, Anda Jana Stroese, Joerg Haier

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: MicroRNA; cancer associated fibroblasts; cell-cell communication; transformation; epigenetic

Online: 28 February 2017 (10:29:27 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0190.v1

Synthesis and Preliminarily Cytotoxicity to A549, HCT116 and MCF-7 Cell Lines of Thieno[2,3-d]pyrimidine Derivatives Containing Isoxazole Moiety

Jianping Yong, Canzhong Lu, Xiaoyuan Wu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Isoxazole moiety; Thieno[2,3-d]pyrimidine derivatives; Synthesis; Anticancer activity

Online: 24 March 2017 (17:52:30 CET)

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Preprint REVIEW | doi:10.20944/preprints201611.0120.v1

Pancreatic Neuroendocrine Neoplasms: Basic Biology, Current Treatment Strategies and Prospects for the Future

Akihiro Ohmoto, Hirofumi Rokutan, Shinichi Yachida

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pNENs; 2010 WHO classification; Ki-67 index; mitotic count; pNEC; tumor differentiation; whole-exome sequence data; everolimus; sunitinib; platinum regimen

Online: 24 November 2016 (10:59:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v2

IQGAP1 in Podosome /Invadosome is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Dolores Pérez-Rodríguez, Manuel Morales, María del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; GBM; scaffold protein; podosome/invadosome

Online: 9 January 2017 (03:21:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0044.v1

Alcohol-containing Mouthwashes and Oral Cancer: A Mechanistic Explanation

José Manuel Calderón-Montaño, Julio José Jiménez-Alonso, Emilio Guillén-Mancina, Estefanía Burgos-Morón, Miguel Lopez-Lazaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer prevention; carcinogenesis; oral cancer; pharynx cancer; mouthrinses; ethanol.

Online: 6 March 2018 (14:28:22 CET)

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Preprint REVIEW | doi:10.20944/preprints202203.0156.v1

Breathing Exercises for Pain Management in Cancer Survivors: A Systematic Review

Haiying Wang, Xian-Liang Liu, Tao Wang, Jing-Yu (Benjamin) Tan, Houqiang Huang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breathing exercises; pain; cancer survivors

Online: 10 March 2022 (15:17:07 CET)

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Preprint REVIEW | doi:10.20944/preprints202003.0201.v1

Oncogenic Signaling Pathways in Cancer: An Overview

Afshin Derakhshani, Zeinab Rostami, Sina Taefehshokr, Hossein Safarpour, Reza Vaezi Astamal, Nima Taefehshokr, Nazila Alizadeh, Antonella Argentiero, Nicola Silvestris, Behzad Baradaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; cell signaling; therapeutic targets; signaling pathways

Online: 12 March 2020 (04:53:02 CET)

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Preprint REVIEW | doi:10.20944/preprints202010.0622.v1

Circulating Tumor Cell Separation of Blood Cells and Sorting in novel Microfluidic approaches: a review

Alireza Farahinia, W.J. Zhang, Ildiko Badea

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Cancerous Cell, Tumors, Cancer Metastasis, Circulating Tumor Cells (CTCs), Microfluidic Devices, lab-On-a-Chip (LOC), Lab-On-a-CD (LOCD)

Online: 29 October 2020 (15:38:54 CET)

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Separation and interpretation of rebellious Circulating Tumor Cells (CTCs) originating from the primary tumor or cancer tissue plays a significant role in diagnostics, cancer progression analyses, suitable medicine exploration, and treatment proficiency examination. Cancer metastasis occurs when CTCs spread throughout the body and invade healthy tissues, leading to new tumors in that area. Although a dramatic rate of deaths begins from spreading CTCs around the body, valuable measures have been made to control their development. However, the first step is separating these harmful cells from the bloodstream and investigating their features. Having examined the characteristics of CTCs as cancer’s main strength, researchers can introduce complementary treatments that can affect cancerous cells without damaging the healthy cells. Therefore, according to their unique characteristics, numerous techniques have been established for continuous and fast separation and sorting of CTCs. Nevertheless, few separators enjoy the efficient performance and appropriate accuracy and can be produced in mass numbers due to the available fabrication equipment. Microfabrication advancements enable separators to combine the advantages of active and passive methods in a small-scale platform for probing individual cells and separation purposes. Reduction in reagents, sample volume, analysis time, and less harmfulness to patients are some of the motivations that encourage researchers to employ microfluidic instruments for CTCs separation from other blood cells over the last two decades. However, microfabrication limitations mean effective separators, and the diagnostic option they provide, are not readily available. Addressing these limitations requires optimizing the design and fabrication of separators such that they are reduced in their size and fabrication cost, while also maintaining high-throughput separating capability. The emergence of the Lab-On-a-Chip (LOC) and then Lab-On-a-CD (LOCD) technologies, having more inherent benefits than conventional microfluidic devices, has created new opportunities and become increasingly widespread in recent years. Evidence suggests that employing single methodologies or integrating approaches without sufficient understanding of potential outcomes is unlikely to result in successful diagnostic results. This paper contributes an extensive review of several separation systems, including fundamental theories and experimental details, and describes detailed operating principles and device performance.

Preprint ARTICLE | doi:10.20944/preprints201703.0215.v1

Discovery and Biological Evaluation of a Series of Pyrrolo[2,3-b]pyrazines as Novel FGFR Inhibitors

zhang yan, Hongchun Liu, Zhen Zhang, Ruifeng Wang, Tongchao Liu, Chaoyun Wang, Yuchi Ma, Jing Ai, Dongmei Zhao, Jingkang Shen, Bing Xiong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: FGFR1; inhibitor; kinase inhibitor; pyrazine; hinge binder

Online: 30 March 2017 (04:13:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v3

IQGAP1 in Podosomes/Invadosomes Is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Pérez-Rodríguez, Manuel Morales, María Del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; glioblastoma multiforme (GBM); scaffold protein; podosome/invadosome

Online: 16 January 2017 (10:30:48 CET)

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Working Paper ARTICLE

Mathematical Modelling of the Dynamics of Tumor Growth and its Optimal Control

Jannatun Irana Ira, Md. Shahidul Islam, Jagadis Chandra Misra, Md. Kamrujjaman

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Mathematical models; tumor growth; chemotherapy; diffusion; optimal control

Online: 5 July 2020 (16:39:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0103.v1

Cancer Etiology: Variation in Cancer Risk among Tissues is Poorly Explained by the Number of Gene Mutations

Miguel Lopez-Lazaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: stem cells; somatic mutations; cancer prevention; carcinogenesis; whole genome sequencing; stem cell division theory of cancer; bad luck of cancer

Online: 30 August 2017 (12:14:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201608.0115.v1

Targeted Cancer Therapy: Vital Oncogenes and a New Molecular Genetic Paradigm for Cancer Initiation Progression and Treatment

Rudolph E. Willis

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: oncogenes; oncogene addiction; carcinogenesis; transcription factor; cancer genome; gene fusion; cancer genetics; cancer stem cell; targeted cancer therapy; personalized medicine

Online: 11 August 2016 (11:04:35 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202003.0350.v1

A Radiation Oncology Departmental Policy for the 2019 Novel Coronavirus (COVID-19) Pandemic

Yuan James Rao, Destie Provenzano, Hiram A. Gay, Paul W. Read, Martin Ojong, Sharad Goyal

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: COVID-19; SARS-CoV-2; coronavirus; novel coronavirus; department policy; radiation oncology

Online: 23 March 2020 (09:55:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201705.0102.v1

Novel Combination of Withaferin A and Sulforaphane Inhibits Epigenetic Machinery, Cellular Viability and Induces Apoptosis of Breast Cancer Cells

Kendra Royston, Neha Udayakumar, Kayla Lewis, Trygve Tollefsbol

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: sulforaphane; withaferin; breast cancer; HDAC1; DNMTs; chemoprevention; epigenetics

Online: 12 May 2017 (05:19:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints201705.0108.v1

Long-Lived Epidermal Cancer-Initiating Cells

Marina Youssef, Andrew Cuddihy, Charbel Darido

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: squamous cell carcinoma (SCC), Grainyhead-like 3 (Grhl3), interfollicular epidermis (IFE), supra-basal epidermis, involucrin (IVL), cancer-initiating cell (CIC), cancer stem cell (CSC).

Online: 12 May 2017 (18:15:31 CEST)

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Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population as well as an economic load to the health care system, yet treatments of these preventable cancers remain ineffective. Although primary prevention is possible through minimising sunlight exposure, the World Health Organisation estimates that between 2 and 3 million new cases of NMSCs are diagnosed each year, accounting for 1 in 3 of all newly diagnosed cancers. Furthermore, studies have estimated there has been a 2-fold increase in the incidence of NMSCs between 1960s and 1980s. The increase in cases of NMSCs as well as the lack of effective treatments makes the need for novel therapeutic approaches all the more necessary. To rationally develop more targeted treatments for NMSCs, a better understanding of the cell of origin, in addition to the underlying pathophysiological mechanisms that govern the development of these cancers, is urgent. NMSCs are generally thought to arise from specific types of stem cells that become the source of clonal expansion of tumourigenic cells. Previous research on SCC has alluded to these stem cells being localised in the basal compartment of the skin, which ordinarily houses the progenitor cells that contribute towards wound healing and normal cell turnover of overlying epidermal skin layers. More recent research has suggested that commitment to differentiation, which requires exiting the basal, progenitor-cell compartment, is a reversible mechanism. Genetic modifications engage differentiated cells into dedifferentiation, converting them into cancer-initiating cells (CICs) and thereby promoting a tumourigenic environment. Here we explore the most recent developments in the understanding of skin SCC cell of origin, and discuss a case study illustrating the loss of the Grainy-head like 3 (GRHL3) transcription factor in suprabasal layers, which confers a tendency towards tumour development and thereby challenging the “stem cell” theory of tumourigenesis.

Preprint REVIEW | doi:10.20944/preprints201910.0296.v1

Nasal Drug Delivery of Anticancer Drugs for the Treatment of Glioblastoma: Preclinical and Clinical Trials

Franciele Aline Bruinsmann, Gustavo Richter Vaz, Aline de Cristo Soares Alves, Tanira Aguirre, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres, Fabio Sonvico

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: nasal delivery; glioblastoma multiforme; drug delivery; nanoparticles; nose-to-brain delivery; pre-clinical studies; clinical evaluation

Online: 27 October 2019 (09:36:27 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0304.v1

A Complex Systems Analysis of Cancer Networks

Abicumaran Uthamacumaran

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; complexity; machine learning; deep learning; fluid dynamics; turbulence; chaos

Online: 27 September 2019 (07:24:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0295.v1

Emerging and Established Models of Bone Metastasis

Alexander H. Jinnah, Benjamin C. Zacks, Chukwuweike Gwam, Bethany A. Kerr

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: bone metastasis; tissue engineering; mesenchymal stem cells; osteoclast; osteoblast; dormancy; mouse models; circulating tumor cell

Online: 23 April 2018 (12:35:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0126.v1

IQGAP1 in Podosome /Invadosome is Involved in the Progression of Glioblastoma Multiforme Depending on the Tumor Status

Deborah Rotoli, Natalia Pérez-Rodríguez, Manuel Morales, María Del Carmen Maeso, Julio Ávila, Ali Mobasheri, Pablo Martín-Vasallo

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: IQGAP1; GBM; scaffold protein; podosome/invadosome

Online: 24 November 2016 (18:02:20 CET)

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Preprint ARTICLE | doi:10.20944/preprints202009.0483.v1

Enhancing the Landscape of Colorectal Cancer Using Targeted Deep Sequencing

Chul Seung Lee, In Hye Song, Ahwon Lee, Jun Kang, Yoon Suk Lee, In Kyu Lee, Young Soo Song, Sung Hak Lee

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: next-generation sequencing; colorectal cancer; ATM mutation; FBXW7 mutation

Online: 20 September 2020 (15:20:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0018.v1

PKM2 Knockdown Induces Autophagic Cell Death via the AKT/mTOR Pathway in Human Prostate Cancer Cells

Prasanta Dey, Amit Kundu, Richa Sachan, Jaehyun Park, Mee Young Ahn, Kyungsil Yoon, Jaewon Lee, Nam Deuk Kim, In Su Kim, Byung Mu Lee, Hyung Sik Kim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pyruvate kinase M2; prostate cancer; cancer metabolism; mTOR; autophagy

Online: 3 January 2019 (12:32:52 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0238.v1

Identification of Potent Inhibitors against Aurora Kinase A Using Molecular Docking and Molecular Dynamics Simulation Studies

Sathishkumar Chinnasamy, Gurudeeban Selvaraj, Aman Chandra Kaushik, Satyavani Kaliamurthi, Asma Sindhoo Nangraj, Chandrabose Selvaraj, Sanjeev Kumar Singh, Ramanathan Thirugnanasambandam, Keren Gu, Donq-qing Wei

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: aurora kinase A; molecular docking; DFT; MD simulation

Online: 23 August 2019 (05:01:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0186.v2

Residence in proximity of a coal-oil-fired thermal power plant and risk of lung and bladder cancer in north-eastern Italy. A population-based study, 1995-2009

Paolo Collarile, Ettore Bidoli, Fabio Barbone, Loris Zanier, Stefania Del Zotto, Simonetta Fuser, Fulvio Stel, Chiara Panato, Irene Gallai, Diego Serraino

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Air pollution; coal-fired thermal power plant; oil thermal power plant; geocoded; lung cancer; bladder cancer; North-eastern Italy

Online: 20 June 2017 (08:50:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0079.v1

Dietary Intake of Meat Cooking-Related Mutagens (HCAs) and Risk of Colorectal Adenoma and Cancer: A Systematic Review and Meta-Analysis

Manuela Chiavarini, Gaia Bertarelli, Liliana Minelli, Roberto Fabiani

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: heterocyclic amines (HCAs); meat intake; colorectal cancer; colorectal adenomas; cancer prevention

Online: 9 May 2017 (06:13:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0082.v1

Mitochondrial Dysfunction and Cytochrome C Translocation Induced by Resveratrol Are Dependent on NF-κB Activity and Facilitate TRAIL Sensitivity in Human Lung Cancers

Mohammad Rasheduzzaman, Jae-Kyo Jeong, Sang-Youel Park

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Resveratrol; autophagy; TRAIL; apoptosis; lung cancer cells; NF-κB; Cytochrome c

Online: 6 April 2018 (18:59:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0097.v1

Indirubin inhibits cell proliferation, migration, invasion andangiogenesis in tumor-derived endothelial cells

Li zhuohong, Zhu chaofu, An baiping, Chen yu, He xinyue, Qian Lin, Lan lan, Shijie Li

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Indirubin; Td-EC; proliferation; migration; invasion; angiogenesis

Online: 20 June 2017 (11:30:51 CEST)

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Preprint REVIEW | doi:10.20944/preprints201808.0044.v1

BRK”ing” Down All We Know About PTK6 in Breast Cancer

Yi Yuan, Hui Li Ang, Xianning Lai, Lingzhi Wang, Vijay Pandey, Benjamin BoJun Huang, Tuan Zea Tan, Hui Yi Chong, Philip Zheng Yang Ong, Kanchugarakoppal S. Rangappa, Frank Arfuso, Kevin Shyong-Wei Tan, Basappa, Boon Cher Goh, Ruby Yun-Ju Huang, Gautam Sethi, Peter E. Lobie, Alan Prem Kumar

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast tumor kinase (BRK); protein tyrosine kinase 6 (PTK6); breast cancer; pathways; therapeutics

Online: 2 August 2018 (09:58:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0074.v1

Breast Cancer Risk Factors in Iran: A Systematic Review and Meta-analysis

Amir Shamshirian, Keyvan Heydari, Zahra Shams, Amir Reza Aref, Danial Shamshirian, Omid Reza Tamtaji, Zatollah Asemi, Hamed Mirzaei, Neda Mohammadi, Behdad Zibaee, Keyvan Karimifar, Bahman Zarandi, Akbar Hedayatizadeh-Omran, Reza Alizadeh-Navaei

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast tumor; mammary neoplasm; breast carcinoma; meta-analysis; population at risk

Online: 7 April 2020 (01:22:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201711.0082.v1

Spectroscopic Evidence, Evaluation of Biological Activity and Prediction of the Safety Profile of Fatty Hydroxamic Acids Derived from Olive Oil Triacylglycerides

Monika Barbarić, Dražen Vikić-Topić, Željko Marinić, Danijela Bakarić, Marijana Zovko Končić, Katarina Mišković Špoljarić, Mirela Baus Lončar, Milena Jadrijević-Mladar Takač

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: fatty hydroxamic acids; synthesis; spectroscopy; antioxidant activity; cytotoxic activity; biological targets; ADMET; safety profile

Online: 14 November 2017 (04:42:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints201710.0157.v1

Docosahexaenoic Acid Induces Cell Death through Downregulation of Hedgehog Signaling via Surt6 Activation in Human EGFR Mutant Non-Small Cell Lung Cancer

Soyeon Jeong, Kaipeng Jing, Soyeon Shin, Soyeon Kim, Seung-Hyeon Han, Yoon-Seon Yoo, Young-Joo Jeon, Jun-Young Heo, Gi-Ryang Kweon, Seung-Kiel Park, Jong-Il Park, Kyu Lim

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: docosahexaenoic acid; apoptosis; SIRT6; Hedgehog signaling; non-small cell lung cancer cells

Online: 24 October 2017 (05:43:16 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201705.0186.v1

Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study, 1995–2009

Paolo Collarile, Ettore Bidoli, Fabio Barbone, Loris Zanier, Stefania Del Zotto, Simonetta Fuser, Fulvio Stel, Chiara Panato, Ilaria Gallai, Diego Serraino

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: air pollution; coal-fired thermal power plant; oil thermal power plant; geocoded; lung cancer; bladder cancer; north-eastern Italy

Online: 25 May 2017 (08:40:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0142.v1

Retrospective Proteomic Screening of 100 Breast Cancer Tissues

Ida Pucci-Minafra, Gianluca Di Cara, Rosa Musso, Patrizia Cancemi, Nadia Ninfa Albanese, Elena Roz, Salvatore Minafra

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer; surgical tissues; gel-based proteomics; mass spectrometry; protein clustering

Online: 24 April 2017 (05:14:06 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0294.v1

Signaling Pathways in Cervical Cancer Chemoresistance: Are microRNAs and Long-Noncoding RNAs the Main Culprits?

Seyyed Reza Mousavi, Nima Hemmat, Hossein Bannazadeh Baghi, Afshin Derakhshani, Stefania Tommasi, Oronzo Brunetti, Behzad Baradaran, Nicola Silvestris

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: signaling pathway; microRNA; long-noncoding RNA; chemoresistence; cervical cancer

Online: 17 April 2020 (08:12:52 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202007.0179.v1

UCSCXenaShiny: An R Package for Exploring and Analyzing UCSC Xena Public Datasets in Web Browser

Shixiang Wang, Yi Xiong, Kai Gu, Longfei Zhao, Yin Li, Fei Zhao, Xuejun Li, Xue-Song Liu

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: UCSC Xena, cancer genomics, TCGA

Online: 9 July 2020 (07:59:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0360.v1

Selective Cytotoxic Activity and DNA Damage by an Epoxyalkyl Galactopyranoside

Estefanía Burgos-Morón, Nuria Pastor, Manuel Luis Orta, Julio José Jiménez-Alonso, Margarita Vega-Holm, José Manuel Vega-Pérez, Fernando Iglesias-Guerra, Santiago Mateos, Miguel Lopez-Lazaro, José Manuel Calderón-Montaño

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: epoxide, cancer, anticancer, cytotoxicity, nucleotide excision repair

Online: 27 April 2018 (14:00:47 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0577.v1

Monoclonal Antibodies for the Treatment of Multiple Myeloma: An Update

Hanley Abramson

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: myeloma; daratumumab; elotuzumab; isatuximab; CD38; JNJ- 63723283; denosumab; checkpoint inhibitors; BCMA; bispecific T-cell engager; antibody-drug conjugates

Online: 24 October 2018 (12:11:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202008.0562.v1

Mutational Hotspots and Conserved Domains in P53 Tumour Suppressor Protein

Olabode E. Omotoso

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: mutations; exon; p53; regulation; DNA; tumour suppressor

Online: 26 August 2020 (09:10:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0071.v1

The Role of Next-Generation Sequencing in Precision Medicine: A Review of Outcomes in Oncology

Margaret Morash, Hannah Mitchell, Himisha Beltran, Olivier Elemento, Jyotishman Pathak

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: precision medicine; next generation sequencing; oncology, patient outcomes; health insurance coverage

Online: 4 July 2018 (11:06:43 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints201806.0343.v1

Breast tumor detection and classification in Mammograms: Gabor wavelet vs. statistical features

Mandeep Singh, Dharmesh Singh, Vipul Sharma

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Lesion classification; statistical features; mammograms

Online: 21 June 2018 (15:46:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0088.v1

Novel Combinatorial Therapeutic Strategy to Overcome Gain-of-Function p53 Mutations

Xiangbing Meng, Shujie Yang, Yujun Li, Yiyang Li, Jianling Bi, Xinhao Wang, Shaikamjad Umesalma, Eric J. Devor, Kristina W. Thiel, Dawn E. Quelle, Kimberly K. Leslie

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: p53; proteasome inhibitor; endometrial cancer; ovarian cancer; gain-of-function mutation

Online: 4 May 2018 (09:03:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0092.v1

Elevated Polyamines in Saliva of Pancreatic Cancer

Yasutsugu Asai, Takao Itoi, Masahiro Sugimoto, Atsushi Sofuni, Takayoshi Tsuchiya, Reina Tanaka, Ryosuke Tonozuka, Mitsuyoshi Honjo, Shuntaro Mukai, Mitsuru Fujita, Kenjiro Yamamoto, Yukitoshi Matsunami, Takashi Kurosawa, Yuichi Nagakawa, Miku Kaneko, Sana Ota, Shigeyuki Kawachi, Motohide Shimazu, Tomoyoshi Soga, Masaru Tomita, Makoto Sunamura

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: pancreatic cancer; saliva; metabolomics; polyamines

Online: 10 January 2018 (15:32:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201806.0177.v1

Screening for Selective Anticancer Activity of 65 Extracts of Plants Collected in Western Andalusia, Spain

José Manuel Calderón-Montaño, Sara María Martínez-Sánchez, Estefanía Burgos-Morón, Emilio Guillén-Mancina, Julio José Jiménez-Alonso, Felipe García, Abelardo Aparicio, Miguel López-Lázaro

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; lung cancer; selectivity; Tetraclinis articulata (Vahl) Mast., Cupressaceae

Online: 12 June 2018 (09:02:50 CEST)

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Preprint REVIEW | doi:10.20944/preprints201807.0217.v1

Prevention of Cervical Cancer in Sub-Saharan Africa: the Promises and Challenges of HPV Vaccination

Eleanor Black, Robyn Richmond

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cervical cancer; HPV vaccination; sub-Saharan Africa

Online: 12 July 2018 (14:32:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201906.0002.v1

Application of Highly Immunocompromised Mice for Establishment of Patient-Derived Xenograft (PDX) Model

Seiji Okada, Kulthida Vaeteewootthacharn, Ryusho Kariya

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: patient-derived xenograft; immunocompromised mice; precision medicine; drug screening; cancer; cell line

Online: 3 June 2019 (04:47:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0183.v1

NRF1-Mediated Oncogenic Reprogramming Drives Estrogen-Induced Breast Carcinogenesis

Jayanta Kumar Das, Quentin Felty, Robert Poppiti, Robert M. Jackson, Deodutta Roy

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: NRF1; oncogenic reprogramming; estrogen; breast cancer

Online: 11 September 2018 (05:27:01 CEST)

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Preprint COMMENTARY | doi:10.3390/sci2020042

Advancing Therapies for Cancer—From Mustard Gas to CAR T

Dillon Jarrell, Seth Drake, Mark Brown

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: small molecule inhibitor; personalized medicine; precision medicine; oncology; targeted therapy; drug delivery; drug screening; chemotherapy

Online: 10 June 2020 (00:00:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0159.v1

Early Diagnosis of Breast Cancer – In Respect to Expectations of Participants in Screening Programs and to Contemporary Research in Imaging Methods

Heino Hille

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Key wordsbrest cancer screening, mammography, breast ultrasound, breast MRI

Online: 29 September 2017 (15:00:08 CEST)

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Preprint REVIEW | doi:10.20944/preprints201802.0011.v1

Opportunities and Resistance to Signal-targeted Therapies in Pancreatic Cancer: What Can We Learn from Proteomic Studies?

Celia Cintas, Thibaut Douche, Julie Guillermet-Guibert

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Pancreatic cancer, proteomics, PI3K pathway, precision medicine, predictor of therapeutic response

Online: 1 February 2018 (17:16:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0215.v1

In Vitro Anticancer Activity and Mechanism of Action of an Aziridinyl Galactopyranoside

Estefanía Burgos-Morón, Nuria Pastor, Manuel Luis Orta, Julio José Jiménez-Alonso, Carlos Palo-Nieto, Margarita Vega-Holm, José Manuel Vega-Pérez, Fernando Iglesias-Guerra, Santiago Mateos, Miguel López-Lázaro, José Manuel Calderón-Montaño

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: aziridine; cancer; cytotoxic; cytotoxicity; selectivity; nucleotide excision repair

Online: 15 May 2018 (09:00:29 CEST)

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Working Paper ARTICLE

Surgery, Chemotherapy and Radiotherapy Promote Cancer Growth Speeds and Shorten Patient Lives

Jianqing Wu, Ping Zha

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: cancer; surgery; chemotherapy; radiotherapy; health optimization; exercises; diet; emotion; chronic stress; kinetics; lethal factors

Online: 24 November 2019 (04:40:48 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0051.v1

TTF1, in the Form of Nanoparticles, Inhibits Angiogenesis, Cell Migration and Cell Invasion in VitroandIn Vivoin Human Hepatoma through STAT3 Regulation

Bin Xiao, Dongjing Lin, Xuan Zhang, Meilan Zhang, Xuewu Zhang

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: angiogenesis; cell invasion; cell migration; Flavone derivative (TTF1); hepatoma; STAT3

Online: 9 November 2016 (10:21:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0467.v1

The Use of Translocator protein 18 kDa (Tspo) as a Biomarker in Various Human Cancers

Nimisha H. Bhoola, Zukile Mbita, Rodney Hull, Zodwa Dlamini

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Tspo; prostate cancer; stomach cancer; colon cancer; liver cancer; lung cancer; kidney cancer; breast cancer; brain cancer

Online: 31 May 2018 (10:59:31 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0076.v1

NGAL is Downregulated in Oral Squamous Cell Carcinoma and Leads to Increased Survival, Proliferation, Migration, and Chemoresistance

Javadi Monisha, Nand Kishor Roy, Ganesan Padmavathi, Kishore Banik, Devivasha Bordoloi, Amrita Devi Khwairakpam, Frank Arfuso, Arunachalam Chinnathambi, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Gautam Sethi, Alan Prem Kumar, Ajaikumar B. Kunnumakkara

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Oral cancer; mTOR pathway; secreted glycoprotein; drug resistance

Online: 3 May 2018 (12:47:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201908.0118.v1

Green Synthesis of Silver Nanoparticles Using Scindapsus officinalis (Gajpipli): In-Vitro Cytotoxic Activity Against HepG-2 & MCF-7 Cancer Cell Lines

Manish Pathak, Vikas Kumar, Prateek Pathak, Rahul Majee, Promod W. Ramteke, Amita Verma

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: Silver nanoparticles, Scindapsus officinalis, MTT assay, HepG-2, MCF-7

Online: 13 August 2019 (09:10:03 CEST)

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Working Paper ARTICLE

Lung Adenocarcinoma Patients Own Higher Risk of SARS-CoV-2 Infection

Long Chen, Li Zhong

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: lung adenocarcinoma; SARS-CoV-2; ACE2; miR-125b-5p; IL6

Online: 26 February 2020 (02:50:17 CET)

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Preprint REVIEW | doi:10.20944/preprints201806.0105.v1

Current Status of Fibroblast Growth Factor Receptors Targeted Therapies in Breast Cancer

Navid Sobhani, Anna Ianza, Alberto D'Angelo, Giandomenico Roviello, Fabiola Giudici, Marina Bortul, Fabrizio Zanconati, Cristina Bottin, Daniele Generali

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: fibroblast growth factor; fibroblast growth factor receptor; targeted treatments; breast cancer

Online: 7 June 2018 (07:50:30 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints201711.0122.v1

On Spatial Relations for Non-small Cells Lungs Cancer Interpretation

Nadeem Salamat, V. B. Surya Prasath, Malik M. Saad Missen

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: computer aided diagnosis; topological relations; TNM system; non-small Cells; lung cancer

Online: 20 November 2017 (07:57:32 CET)

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Preprint REVIEW | doi:10.20944/preprints201908.0038.v1

STAT3 and STAT5 Activation in Solid Cancers

Sebastian Igelmann, Heidi A. Neubauer, Gerardo Ferbeyre

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: solid cancers; cell cycle; apoptosis; inflammation; mitochondria; stemness; tumor suppression

Online: 5 August 2019 (03:43:33 CEST)

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Working Paper ARTICLE

A Hybrid Ensemble Method for Accurate Breast Cancer Tumor Classification using State-of-the-Art Classification Learning Algorithms

Adel Saad Assiri, Sergio Velastin, Saima Nazir

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: breast cancer tumor; classification; majority-based voting mechanism; multilayer perceptron learning network; simple logistic regression; stochastic gradient descent learning; wisconsin breast cancer dataset

Online: 27 November 2019 (09:51:31 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0546.v1

Atezolizumab and Pembrolizumab in Triple-Negative Breast Cancer: A Meta-Analysis

Mahwish Amin, Shaiza Sharif, Waleed Asghar, Humaira Sadaf, Azza Sarfraz, Zouina Sarfraz, Ivan Cherrez-Ojeda

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: triple negative breast cancer; Pembrolizumab; Atezolizumab; chemotherapy; anti-PD-L1; biomarkers; targeted therapies; development of novel drugs

Online: 24 May 2021 (09:23:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0174.v1

Whole Genome Transcriptome Analysis of the Association between Obesity and Triple Negative Breast Cancer in Caucasian Women

Tarun Mamidi, Jiande Wu, Paul B. Tchounwou, Lucio Miele, Chindo Hicks

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: gene expression obesity triple negative breast cancer

Online: 20 March 2018 (07:56:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0163.v1

Ultraconserved Long Non-Coding RNA Uc.112 is Abnormally Expressed in Childhood Acute Lymphoblastic Leukemia Subtypes

Pablo Chagas, Graziella Sousa, Marcio Kodama, Carlos Biagi Junior, José Yunes Andres, Silvia Brandalise, George Calin, Luiz Tone, Carlos Scrideli, Jaqueline Oliveira

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: T-UCR; pediatric acute lymphoblastic leukemia; uc.112; T-ALL; hyperdiploidy.

Online: 8 October 2018 (17:01:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints201803.0076.v1

Conflicting Roles of Connexin43 in Tumor-Induced Inflammation and Cancer Pathology

Miaki Uzu, Wun Chey Sin, Ayaka Shimizu, Hiromi Sato

Subject: Medicine And Pharmacology, Oncology And Oncogenics Keywords: connexin43; central nervous system; glioma; astrocyte; blood brain barrier; neurovascular unit

Online: 12 March 2018 (04:20:03 CET)

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The tumor microenvironment is known to have increased levels of cytokines and metabolites, such as glutamate, due to their release from the surrounding cells. A normal cell around the tumor that responds to the inflammatory environment is likely to be subsequently altered. We will discuss how these abnormalities will support tumor survival via the actions of gap junctions (GJs) and hemichannels (HCs) which are composed of hexamer of connexin 43 (Cx43) protein. In particular, we will discuss how GJ intercellular communication (GJIC) in glioma cells, the primary brain tumor, is a regulatory factor and its attenuation leads to tumor invasion. In contrast, the astrocytes, which are normal cells around the glioma, are "hijacked" by tumor cells, either by receiving the transmission of malignant substances from the cancer cells via GJIC, or perhaps via astrocytic HC activity through the paracrine signaling which enable the delivery of these substances to the distal astrocytes. This astrocytic signaling would promote tumor expansion in the brain. In addition, brain metastasis from peripheral tissues has also been known to be facilitated by GJs formed between cerebral vascular endothelial cells and cancer cells. Astrocytes and microglia are generally thought to eliminate cancer cells at the blood brain barrier. In contrast, some reports suggest they facilitate tumor progression as tumor cells take advantage of the normal functions of astrocytes that support the survival of the neurons by exchanging nutrients and metabolites. In summary, GJIC is essential for the normal physiological function of growth and allowing the diffusion of physiological substances. Therefore, whether GJIC is cancer promoting or suppressing may be dependent by what permeates through GJs, when it is active, and to which cells. The nature of GJs, which has been ambiguous in brain tumor progression, will need to be re-visited and understood together with new findings on Cx proteins and HC activities.

Medicine and Pharmacology