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Preprint ARTICLE | doi:10.20944/preprints201707.0014.v1

Principles of Dynamic Network Reconfiguration across Diverse Brain States

James M. Shine, Russell A. Poldrack

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: network; topology; integration; segregation; fMRI

Online: 10 July 2017 (05:48:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0148.v1

Ultrasound-Guided Nerve Hydrodissection for Pain Management: An Updated Review of Anatomy and Techniques

King Hei Stanley Lam, Chen-Yu Hung, Yi-Pin Chiang, Kentaro Onishi, Thomas B. Clark, Dean K Reeves, Su Daniel

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: nerve hydrodissection; pain management; ultrasonography; neuropathic pain

Online: 15 January 2020 (12:09:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints202309.2091.v1

Assessing Functional Capacity in ME/CFS: A Patient Informed Questionnaire

Kristian Sommerfelt, Trude Schei, Katharine A Seton, Simon R Carding

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: ME/CFS; chronic fatigue syndrome; functional capacity; post exertional malaise; questionnaire; survey

Online: 29 September 2023 (09:21:59 CEST)

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Working Paper CONCEPT PAPER

EUROPEAN ME NETWORK (EUROMENE) Expert Consensus on the Diagnosis, Service Provision and Care of People with ME/CFS in Europe

Luis Nacul, Fraçois Jérôme Authier, Carmen Scheibenbogen, Lorenzo Lorusso, Ingrid Helland, Jose Alegre Martin, Carmen Adella Sirbu, Anne Marit Mengshoel, Olli Polo, Uta Behrends, Henrik Nielsen, Patricia Grabowski, Slobodan Sekulic, Nuno Sepulveda., Fernando Esteves Lopez, Pawel Zalewski, Derek Pheby, Jesus Castro-Marrero, Giorgos K Sakkas, Jonas Bergquist, Enrica Capelli, Ivan Brandslund, John Cullinan, Angelika Krumina, Modra Murovska, Ruud Vermuelen, Eliana Lacerda

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome; diagnosis; Health services; clinical care

Online: 16 October 2020 (08:58:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints201611.0138.v1

Review of Computational Methods on Brain Symmetric and Asymmetric Analysis from Neuroimaging Techniques

P. Kalavathi, K. Senthamilselvi, V. B. Surya Prasath

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: computational imaging; midsagittal plane; inter-hemispheric fissure; symmetry analysis; neuroimaging

Online: 28 November 2016 (02:03:34 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202304.0108.v1

Towards a Biological Definition of Parkinson’s Disease

Günter U. Höglinger, Charles H. Adler, Daniela Berg, Christine Klein, Tiago F. Outeiro, Werner Poewe, Ronald Postuma, Jon Stoessl, Anthony E. Lang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; genetics; α-synuclein; neurodegeneration; clinical manifestation; diagnosis

Online: 7 April 2023 (03:54:11 CEST)

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With the growing hope that disease-modifying treatments could target the molecular basis of neurodegenerative diseases even before the onset of symptoms, there is mounting pressure to define disease entities based on pathophysiology rather than on clinical syndromes. The Alzheimer’s disease research community has recently transitioned from diagnostic criteria based on an amnestic syndrome to a purely biomarker-based disease definition, relying on the demonstration of amyloid-beta pathology, tau pathology, and neurodegeneration. In contrast, current diagnostic criteria for Parkinson’s disease still rely on the presence of the well-described clinical syndrome of parkinsonism, with the addition of characteristic motor- and non-motor signs and symptoms. However, there is now unequivocal evidence that Parkinson’s disease starts years before the onset of parkinsonism. Furthermore, neuropathologically defined Lewy body disease is clinically heterogeneous, combining a range of motor, non-motor, dopaminergic and non-dopaminergic features. Finally, clinically defined Parkinson’s disease has diverse underlying etiologies most, but not all, associated with α-synuclein positive Lewy pathology. In light of recent scientific advances, we propose a biologically based definition for the diagnosis of Parkinson's disease, initially to be used for research purposes. The criteria use a three-component ‘G-S-N’ system. The first is documentation of defined gene variants (‘G’), which cause or strongly predispose to PD as the most upstream component. The second is α-synuclein pathology (‘S’), currently defined as pathological α-synuclein deposition in tissue or positive α-synuclein seeding assays. The third is evidence of underlying neurodegeneration (‘N’), currently defined by specific neuroimaging procedures. The associated clinical syndrome (‘C’) is defined by a single high-specificity feature or multiple lower-specificity features. Initiating this transition will enable the field to fuel both basic and clinical research and move closer to the precision medicine required to develop clinically meaningful disease-modifying therapies. We acknowledge current limitations, ethical implications, and the need for prospective validation of this approach.

Preprint REVIEW | doi:10.20944/preprints201701.0027.v1

iPad Use in Stroke Neuro-Rehabilitation

Khalid Ameer, Khalid Ali

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: iPad; tablet computers; Stroke; neuro-rehabilitation

Online: 5 January 2017 (09:56:53 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201708.0106.v1

A Rare Case of Aicardi-Goutières Syndrome Who Showed a Positive Evolution after Being Treated with Growth Hormone, High Doses of Melatonin and Neurorehabilitation

Jesús Devesa, Alba Alonso, Patricia Porto, Ana Quintana, María Carrillo, Pablo Devesa, Carlos Israel Puell

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Aicardi-Goutiéres syndrome; interferon 1; melatonin; growth hormone; neurorehabilitation

Online: 31 August 2017 (12:30:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201609.0024.v1

Identification of One BOCR Mutation and Five NF1 Mutations in Male Patients with Neurofibromatosis Type 1 and Congenital Pseudarthrosis of the Tibia

Zhifan Zhou, Yong Zeng, Xinchun Wu, Fei Li, Xiaoyan Liu, Lu Zhou, Lihua Hou, Silong Sun, Lu Shen, Zhangyuan Lin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurofibromatosis type 1; congenital pseudarthrosis of the tibia; whole-exome sequencing; targeted sequencing; BCOR

Online: 7 September 2016 (11:19:00 CEST)

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Preprint REVIEW | doi:10.20944/preprints202001.0370.v1

CCL11 or Eotaxin-1: An Immune Marker for Ageing and Accelerated Ageing in Neuro-psychiatric Disorders

Mariya Ivanovska, Zakee Abdi, Marianna Murdjeva, Danielle Macedo, Annabel Maes, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: eotaxin; immune marker; neuroinflammation; ageing; neuro-psychiatric disorder

Online: 30 January 2020 (14:42:45 CET)

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Preprint REVIEW | doi:10.20944/preprints201801.0179.v1

Proteostasis in Huntington’s Disease: Disease Mechanisms and Therapeutic Opportunities

Rachel J. Harding, Yufeng Tong

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Huntington’s disease; neurodegenerative diseases; autophagy; proteostasis; proteasomal degradation

Online: 19 January 2018 (04:25:29 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0503.v1

Central Nervous System Depressant Drugs: Updated Review

Abdullah Alkattan, Eman Alsalameen, Amr Ahmed

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: CNS; Drug receptors; GABA; Cannabinoid; Opioid; Serotonin; Dopamine

Online: 25 January 2021 (14:15:20 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202004.0305.v1

Latent Tuberculosis Infection in Patients with Multiple Sclerosis

Isabelle Pastor Bandeira, Caroline Figueiredo da Silva, Maria Eduarda Marchi Martin, Gustavo Figueiredo da Silva, Laura Fiuza Parolin, Luiz Henrique Melo, Marcus Vinicius Magno Goncalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: multiple sclerosis; tuberculosis; immunosuppressive therapy; Latent tuberculosis

Online: 17 April 2020 (15:34:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0054.v1

Neuropsychiatric Borreliosis/Tick-Borne Disease: An Overview

Robert C Bransfield

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Lyme disease; Borrelia burgdorferi; tickborne diseases; persistent infection; treatment; assessment; depression; anxiety; sleep disorders; opioid addiction

Online: 5 June 2018 (08:33:20 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0010.v1

Synergistic Effect of Coadministration of Haemophilus influenzae and Neisseria meningitidis Vaccines on Immune Responses to Meningitis in Mouse Model

Randa H. Ali, Nourtan F. Abdeltawab, Osama A. Hady, Magdy A. Amin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Haemophilus influenza; Neisseria meningitidis; meningitis; vaccine efficacy evaluation; immunization schedule.

Online: 2 January 2017 (18:14:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0133.v1

Growth Hormone (GH) and Rehabilitation Promoted Distal Innervation in a Child Affected from a Syndrome of Caudal Regression

Jesús Devesa, Alba Alonso, Natalia López, José García, Carlos Israel Puell, Tamara Pablos, Pablo Devesa

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: GH; syndrome of caudal regression; sacral agenesis; physiotherapy; neurogenic bladder; flaccid paraplegia

Online: 27 November 2016 (04:35:36 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201805.0300.v1

Rett Syndrome: Treatment with IGF-1, Melatonin, Blackcurrant Extracts, and Rehabilitation

Jesús Devesa, Olga Devesa, María Carrillo, Nerea Casteleiro, Ana Devesa, David Llorente, Cristina González

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: IGF-1; MT; Blackcurrant extracts; Oxidative stress; Mecp2; Speech therapy; Neurostimulation; cyclic glycine-proline; GPE.

Online: 22 May 2018 (11:25:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201706.0034.v1

The Role of SNCA Rep1 Microsatellite in Parkinson’s Disease Progression

Lucia Corrado, Fabiola De Marchi, Sara Tunesi, Gaia Oggioni, Miryam Carecchio, Luca Magistrelli, Silvana Tesei, Giulio Riboldazzi, Alessio Di Fonzo, Clarissa Locci, Ilaria Trezzi, Roberta Zangaglia, Cristina Cereda, Sandra D'Alfonso, Corrado Magnani, Comi Giacomo Pietro, Giorgio Bono, Claudio Pacchetti, Roberto Cantello, Stefano Goldwurm, Cristoforo Comi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dementia; hallucinations; genetics

Online: 6 June 2017 (08:39:30 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201612.0105.v5

Implantable Systems for Continuous Liquorpheresis and CSF Replacement

Manuel Menendez Gonzalez

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: csf; shunt; filtration; neurodegenerative; neuroimmunology; alzheimer; parkinson; guillain-barre; device; ventriculo-peritoneal shunt

Online: 30 January 2017 (14:22:03 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0378.v1

Advances in Research on the Relationship between Intestinal Flora and Myasthenia Gravis

Xingxing Wu, Yong Xu, Qin Wang, Yuhui Wei, Md Rezaul Karim, Yun-Fu Wang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: intestinal flora; myasthenia gravis; research progress; autoimmune disease; EAMG

Online: 23 May 2020 (16:40:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0591.v1

Neuromuscular Adverse Events Associated with Anti-PD-1 Monoclonal Antibodies: Systematic Review

Annette Johansen, Søren Just Christensen, David Scheie, Joan L. S. Højgaard, Daniel Kondziella

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: adverse events; immune checkpoint inhibitor; myasthenia gravis; myopathy; neuropathy; nivolumab; pembrolizumab

Online: 29 September 2018 (11:28:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0114.v1

A Possible Role of an Interaction of the Age at Common Childhood Infections and Selected Dietary Factors at Young Age, for the Risk of Multiple Sclerosis

Klaus Lauer, Annette Wahl, Marcel Geilenkeuser

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: multiple sclerosis; epidemiology; diet; childhood infections; interaction

Online: 22 November 2016 (13:00:45 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0453.v1

Neurological Manifestations and Complications of COVID-19: A Literature Review

Imran Ahmad, Farooq Azam Rathore

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurology; clinical features; coronavirus; stroke; encephalitis; headache; delirium

Online: 25 April 2020 (02:36:21 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202009.0297.v1

SARS-CoV-2 Infection in the Central Nervous System of a 1-Year-Old Infant Submitted to Complete Autopsy

Ismael Carlos Gomes, Karina Karmirian, Julia Oliveira, Carolina Pedrosa, Fernando Colonna Rosman, Leila Chimelli, Stevens Rehen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: SARS-CoV-2; COVID-19; CNS; infant; Choroid plexus

Online: 13 September 2020 (16:16:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201702.0054.v1

Identification of the Sixth Ig-like Domain of VCAM-1 as a Novel Therapeutic Target in Lung Cancer Cell Invasion

Mi Ra Kim, Ji Hye Jang, Chang Sik Park, Taek-Keun Kim, Youn-Jae Kim, Junho Chung, Hyunbo Shim, In Hyun Nam, Jung Min Han, Sukmook Lee

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: human antibody; invasion; lung cancer; therapeutic target; VCAM-1; VCAM-1-D6

Online: 15 February 2017 (10:45:16 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints202004.0304.v1

Neurological Complications of Pandemic COVID-19: What Have We Got So Far?

Isabelle Pastor Bandeira, Marco Antônio Machado Schlindwein, Leticia Caroline Breis, Jean Pierre Schatzmann Peron, Marcus Vinicius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; SARS-CoV-2; Neurology; coronavirus

Online: 17 April 2020 (15:27:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints201703.0095.v1

Melatonin as an Interventional Novel Candidate for the Individual with Autistic Fragile X Syndrome in Human

Jinyoung Won, Yunho Jin, Tae Ho Lee, Sang-Rae Lee, Kyu-Tae Chang, Yonggeun Hong

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: autism spectrum disorders; fragile X syndrome (FXS); sleep disorder; melatonin

Online: 15 March 2017 (07:40:49 CET)

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Preprint REVIEW | doi:10.20944/preprints202004.0330.v1

Brainstem Dysfunction in SARS-COV2 Infection Can Be a Potential Cause of Respiratory Distress

Calixto Machado, Joel Victor Gutierrez

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: SARS-CoV-2 (CoV-2); COVID-19; coronavirus; pandemic; respiratory distress; brainstem; respiratory center

Online: 19 April 2020 (05:37:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201712.0128.v1

A Deep Learning Model of Perception in Color-Letter Synesthesia

Joel R. Bock

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: synesthesia; deep learning network; color perception; generative adversarial network; cognitive modeling; character recognition; GPU computing

Online: 19 December 2017 (06:45:50 CET)

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Preprint REVIEW | doi:10.20944/preprints202006.0147.v1

Novel Therapeutic Targets and Biomarkers for the Treatment of Progressive Supranuclear Palsy

Imogen Tyer, Alison Hill

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: PSP; Progressive Supranuclear Palsy; 4R-tau; four-repeat tau; MAPT; Microtubule-associated ligand; PET; Positron Emission Tomography

Online: 12 June 2020 (09:41:06 CEST)

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Preprint BRIEF REPORT | doi:10.20944/preprints201707.0022.v1

Validation Study of Italian Version of Inventory for DéJà vu Experiences Assessment (I-IDEA): A Screening Tool to Detect DéJà vu Phenomenon in Italian Healthy Individuals

Laura Mumoli, Giovanni Tripepi, Umberto Aguglia, Antonio Augimeri, Rossella Baggetta, Francesca Bisulli, Antonella Bruni, Salvatore M. Cavalli, Alfredo D'Aniello, Ornella Daniele, Carlo Di Bonaventura, Giancarlo Di Gennaro, Jinane Fattouch, Edoardo Ferlazzo, Alessandra Ferrari, Annateresa Giallonardo, Sara Gasparini, Salvatore Nigro, Andrea Romigi, Vito Sofia, Paolo Tinuper, Maria Grazia Vaccaro, Leila Zummo, Aldo Quattrone, Antonio Gambardella, Angelo Labate

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Déjà Vu; Inventory for Déjà Vu Experiences Assessment (IDEA)

Online: 11 July 2017 (16:05:10 CEST)

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Preprint REVIEW | doi:10.20944/preprints201712.0111.v1

The Relationship between Autism Spectrum Disorder and Melatonin during Fetal Development

Yunho Jin, Jeonghyun Choi, Jinyoung Won, Yonggeun Hong

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: autism spectrum disorder; melatonin; fetal development; neuroprotection; circadian rhythm

Online: 17 December 2017 (08:41:18 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0365.v1

Molecular Modelling and Docking Experiments Examining the Interaction between SARS-CoV-2 Spike Glycoprotein and Neuronal Nicotinic Acetylcholine Receptors

Konstantinos Farsalinos, Elias Eliopoulos, Demetres Leonidas, Georgios Papadopoulos, Socrates Tzartos, Konstantinos Poulas

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; SARS-CoV-2; smoking; nicotine; nicotinic cholinergic system; inflammation; acetylcholine receptors

Online: 23 May 2020 (10:06:14 CEST)

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Preprint REVIEW | doi:10.20944/preprints201812.0200.v1

MicroRNA cross-involvement in Autism Spectrum Disorders and Atopic Dermatitis: a literature review

Alessandro Tonacci, Gianluca Bagnato, Gianluca Pandolfo, Lucia Billeci, Francesco Sansone, Raffaele Conte, Sebastiano Gangemi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Allergy; Autistic Disorder; Dermatitis; Genetics; Immunity; MicroRNAs

Online: 17 December 2018 (15:53:35 CET)

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Preprint CONCEPT PAPER | doi:10.20944/preprints201612.0105.v2

A CSF Shunt System for Liquorpheresis and CSF Replacement

Manuel Menéndez González

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: csf; shunt; filtration; neurodegenerative; neuroimmunology; alzheimer; parkinson; guillain-barre; device; ventriculo-peritoneal shunt

Online: 21 December 2016 (10:12:13 CET)

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Preprint REVIEW | doi:10.20944/preprints201709.0050.v1

Nanotherapy for Early Dementia: Targeting Senile Endothelium

Joseph S. D'Arrigo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's-disease; dementia; drug targeting; nanoemulsion; neuroinflammation; oxidative stress; scavenger receptors; sonoporation; transcranial ultrasound

Online: 13 September 2017 (05:44:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints201706.0067.v1

Transition from Pediatric Care to Adult Care in Headache Patients

Allyson Bazarsky , Shalonda K. Slater , Hope L. O’Brien

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Transition Medicine; Pediatric migraine; Pediatric; Migraine; Migraine in young adults

Online: 14 June 2017 (09:26:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints201810.0014.v1

Neurologic and Inflammatory Manifestations in Sjögren’s Syndrome: The Role of Tryptophan/kynurenine Pathway

Fabiola Reis Oliveira, Marina Zilio Fantucci, Leidiane Adriano, Valeria Valim, Thiago Mattar Cunha, Paulo Louzada Junior, Eduardo Melani Rocha

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: IDO, kynurenine, pain, Sjögren’s syndrome, tryptophan

Online: 1 October 2018 (14:59:23 CEST)

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Preprint REVIEW | doi:10.20944/preprints202006.0074.v1

Management of Myasthenia Gravis During COVID-19 Pandemic

Xingxing Wu, Jiang Yuan, Md Rezaul Karim, Yun-Fu Wang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; myasthenia gravis; respiratory management

Online: 7 June 2020 (09:28:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202002.0452.v1

Virtual Reality Tremor Reduction in Parkinson's Disease

John Cornacchioli, Alec Galambos, Stamatina Rentouli, Robert Canciello, Roberta Marongiu, Daniel Cabrera, eMalick G. Njie

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neurodegeneration; Parkinson's disease; essential tremor; Deep Brain stimulation; Levodopa; Virtual Reality; Oculus Rift; Medical Virtual Reality; Tremor stabilization; Equalizers

Online: 29 February 2020 (03:56:19 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0421.v1

Dengue Fever and Neurology: Well Beyond Hemorrhage and Strokes

Marco Antônio Machado Schlindwein, Isabelle Pastor Bandeira, Letícia Caroline Breis, Júlia Machado Rickli, Caio César Demore, Beatriz Sordi Chara, Luiz Henrique Melo, Marcus Vinícius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dengue; dengue fever; neurology; neuroimmunology

Online: 26 May 2020 (05:43:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0056.v1

Association between Cervical Spondylosis and Migraine: A Nationwide Retrospective Cohort Study

Wang-Sheng Lin, Tung-Fu Huang, Tien-Yow Chuang, Cheng-Li Lin, Chia-Hung Kao

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cervical spondylosis; migraine; retrospective cohort study; population-based

Online: 7 February 2018 (06:40:48 CET)

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Preprint REVIEW | doi:10.20944/preprints202009.0293.v1

Potential Pathological Biomarkers in Multiple Sclerosis

Deepali Mathur, Soumyashree Rout, Bikash Kumar Mishra, Gerardo Lopez Rodas, Jayalakshmi Vallamkondu, Ramesh Kandimalla, Bonaventura Casanova

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Biomarkers; Multiple Sclerosis; diagnostic; disease activity; Myelin oligodendrocyte glycoprotein antibody (MOG) diseases

Online: 13 September 2020 (15:49:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0015.v1

Swallowing Speed as Potential Predictor of Aspiration in Parkinson’s Disease Patients

Christina Pflug, Almut Niessen, Carsten Buhmann, Moritz Bihler

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dysphagia; FEES; Parkinson’s disease; swallowing speed; screening; water test

Online: 1 April 2019 (13:32:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202004.0376.v1

Urinary Tract Infection in Patients with Multiple Sclerosis: An Overview

Washigton Luiz Gomes de Medeiros Junior, Caio Cesar Demore, Larissa Peres Mazaro, Matheus Fellipe Nascimento de Souza, Laura Fiuza Parolin, Luiz Henrique Melo, Claudio Rogerio Werka Junior, Marcus Vinicius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: urinary tract infection; multiple sclerosis; hospitalization and mortality rate

Online: 21 April 2020 (06:03:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0103.v1

Cytokine Release Syndrome-Associated Encephalopathy in Patients with COVID-19

Peggy Perrin, Nicolas Collongues, Seyyid Baloglu, Dimitri Bedo, Xavier Bassand, Thomas Lavaux, Gabriela Gautier, Nicolas Keller, Stephane Kremer, Samira Fafi-Kremer, Bruno Moulin, Ilies Benotmane, Sophie Caillard

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: clinical medecine; physiopathology; COVID-19; neurological manifestations; kidney disease; cytokine; corticosteroids; intravenous immunoglobulins

Online: 7 June 2020 (15:50:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0080.v1

Implantation of Elongated Porous Silicon Neural Probe Array in Rat Cortex

Mohamad Hajj-Hassan, Rayan Fayad, Soumaya Berro, Vamsy P. Chodavarapu, Sam Musallam

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: cognitive neural prosthetics; brain machine interfaces; porous silicon; microprobes

Online: 9 January 2018 (09:14:39 CET)

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Preprint REVIEW | doi:10.20944/preprints202006.0198.v1

Sudden Onset, Acute Loss of Taste and Smell in Coronavirus Disease 2019 (COVID-19): A Systematic Review

Lakshman SAMARANAYAKE, Kausar Fakhruddin, Chamila Panduwawala

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: loss of taste and smell; dysgeusia; anosmia; chemosensory dysfunction; SARS-CoV-2; COVID-19

Online: 16 June 2020 (07:46:15 CEST)

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Preprint REVIEW | doi:10.20944/preprints202002.0396.v1

Sirtuins, Mitochondria and the Melatonergic Pathway in Alzheimer’s Disease

George Anderson, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; sirtuins; mitochondria; leaky gut; inflammation; neuroimmune

Online: 27 February 2020 (10:52:33 CET)

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Working Paper REVIEW

Hearing Loss and Brain Plasticity: The Hyperexcitability Phenomenon

Björn Herrmann, Blake Butler

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: hearing loss; aging; hyperexcitability; loss of inhibition; neurophysiology; auditory perception; neural plasticity; speech processing

Online: 5 September 2020 (04:54:15 CEST)

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Preprint CONCEPT PAPER | doi:10.20944/preprints202009.0744.v1

Recommendations for Epidemiological Research in ME/CFS from the EUROMENE Epidemiology Working Group

Kathleen Mudie, Fernando Estévez-López, Slobodan Sekulic, Andrejs Ivanovs, Nuno Sepulveda, Pawel Zalewski, Anne Marit Mengshoel, Jean-Dominique De Korwin, Natasa Hinic Capo, Jose Alegre-Martin, Jesus Castro-Marrero, Modra Murovska, Luis Nacul, Eliana Lacerda

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), Data Collection Standardisation, Research Guidelines, Europe

Online: 30 September 2020 (12:24:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0332.v1

Efficacy of a Gluten-Free Diet in the Gilles de la Tourette Syndrome: A Pilot Study

Luis Rodrigo, Nuria Álvarez, Enrique Fernández-Bustillo, Javier Salas-Puig, Marcos Huerta, Carlos Hernández-Lahoz

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Gilles de la Tourette syndrome (GTS); children and adults; motor and vocal/phonic tics; obsessive-compulsive disorder (OCD); non-coeliac gluten sensitivity (NCGS); gluten-free diet; one-year adherence

Online: 26 April 2018 (06:26:55 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0407.v1

A Review of the Complex Roles of Glial Cells in Alzheimer’s Disease and Potential Glial-Oriented Therapeutic Targets

Saif Shahriar Rahman Nirzhor, Rubayat Islam Khan, Sharmind Neelotpol

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Glial Cells, Astrocytes, NG2 Glia, Microglia, Oligodendrocytes, Alzheimer’s disease, Neurodegenerative disease. Aβ-peptides

Online: 26 June 2018 (10:24:02 CEST)

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Working Paper REVIEW

Precision Medicine in Parkinson’s Disease Patients with LRRK2 and GBA Risk Variants – Let’s Get Even More Personal

Christian U. von Linstow, Ziv Gan-Or, Patrik Brundin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s disease; precision medicine; personalized medicine; GBA; Glucocerebrosidase; GCase; LRRK2; Leucine-rich repeat kinase-2; Dopamine; PD drug trials; PD risk variants

Online: 14 September 2020 (00:22:59 CEST)

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Parkinson’s disease (PD) is characterized by motor deficits and a wide variety of non-motor symptoms. The age of onset, rate of disease progression and the precise profile of motor and non-motor symptoms display considerable individual variation. Neuropathologically, the loss of substantia nigra dopaminergic neurons is a key feature of PD. The vast majority of PD patients exhibit alpha-synuclein aggregates in several brain regions, but there is also great variability in the neuropathology between individuals. While the dopamine replacement therapies can reduce motor symptoms, current therapies do not modify the disease progression. Numerous clinical trials using a wide variety of approaches have failed to achieve disease modification. It has been suggested that the heterogeneity of PD is a major contributing factor to the failure of disease modification trials, and that it is unlikely that a single treatment will be effective in all patients. Precision medicine, using drugs designed to target the pathophysiology in a manner that is specific to each individual with PD, has been suggested as a way forward. PD patients can be stratified according to whether they carry one of the risk variants associated with elevated PD risk. In this review we assess current clinical trials targeting two enzymes, leucine-rich repeat kinase 2 (LRRK2) and glucocerebrosidase (GBA), which are encoded by two most common PD risk genes. Because the details of the pathogenic processes coupled to the different LRRK2and GBA risk variants are not fully understood, we ask if these precision medicine-based intervention strategies will prove “precise“ or “personalized“ enough to modify the disease process in PD patients. We also consider at what phases of the disease that such strategies might be effective, in light of the genes being primarily associated with the risk of developing disease in the first place, and less clearly linked to the rate of disease progression. Finally, we critically evaluate the notion that therapies targeting LRRK2 and GBA might be relevant to a wider segment of PD patients, beyond those that actually carry risk variants of these genes.

Preprint ARTICLE | doi:10.20944/preprints201712.0138.v1

TGF-Beta 1 and the Spinal Cord-Specific Outcome of Multiple Sclerosis Active Plaques

Serge Nataf

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: multiple sclerosis; spinal cord; transforming growth factor beta 1; active plaques

Online: 20 December 2017 (07:04:10 CET)

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Preprint REVIEW | doi:10.20944/preprints201804.0026.v1

The Role of Transcranial Magnetic Stimulation as a Diagnostic Tool for Multiple Sclerosis

Shahid Bashir, Muhannad M. Alsharidah, Sarah S.Alseneidi, Afnan A. Alkharan, Ali Hamza

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: MS: Multiple sclerosis, TMS: transcranial magnetic stimulation, Evoked Potentials;

Online: 2 April 2018 (16:03:29 CEST)

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Preprint REVIEW | doi:10.20944/preprints201709.0166.v1

Alzheimer's Disease, Brain Injury, and C.N.S. Nanotherapy in Humans: Sonoporation Augmenting Drug Targeting

Joseph S. D'Arrigo

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer's disease; drug targeting; nanoemulsion; neuroinflammation; neurotrauma; oxidative stress; scavenger receptors; SR-BI; transcranial sonoporation

Online: 30 September 2017 (05:21:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202004.0001.v1

Power Spectral Analysis upon Disfluent Utterance in Adults Who Stutter; a qEEG-based Investigation

Masoumeh Bayat, Reza Boostani, Malihe Sabeti, Fariba Yadegari, Mohammadreza Pirmoradi, Rao KS, Mohammad Nami

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stuttering; power spectra; speech preparation; imagined speech; simulated speech

Online: 1 April 2020 (07:52:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201810.0414.v1

In Schizophrenia, Increased Plasma Igm/Iga Responses to Gut Commensal Bacteria are Associated with Negative Symptoms, Neurocognitive Impairments and the Deficit Phenotype

Michael Maes, Buranee Kanchanatawan, Sunee Sirivichayakul, Andre F. Carvalho

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: immune, inflammation, natural IgM, B1 cells, oxidative stress, TRYCATs, schizophrenia, psychosis, psychiatry

Online: 18 October 2018 (10:55:52 CEST)

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Increased gut permeability (leaky gut) with increased translocation of Gram-negative bacteria plays a role in the gut-brain axis through effects on systemic immune-inflammatory processes. Deficit schizophrenia is characterized by an immune-inflammatory response combined with a deficit in natural IgM antibodies to oxidative specific epitopes (OSEs), which are a first line defense against bacterial infections. This study measured plasma IgA/IgM responses to 5 Gram-negative bacteria in association with IgM responses to malondialdehyde (MDA) and azelaic acid in 80 schizophrenia patients (40 with the deficit syndrome and 40 without) and in 38 healthy controls.Deficit schizophrenia was characterized by significantly increased IgA responses to Hafnei alvei, Pseudomonas aeruginosa, Morganella morganii and Klebsiella pneumoniae as compared with non-deficit schizophrenia. The presence of deficit schizophrenia was highly predicted by increased IgA responses to Pseudomonas putida and IgM responses to all 5 Gram-negative bacteria and lowered natural IgM to MDA and azelaic acid with a bootstrap area under the ROC curve of 0.960 (2000 random curves). A large proportion of the variance (41.5%) in the PANSS negative score was explained by the regression on IgA responses to K. pneumoniae and IgM responses to the 5 enterobacteria coupled with lowered IgM antibodies to azelaic acid. There were significant associations between IgA levels to Gram-negative bacteria and Mini Mental State Examination, Boston naming test, Verbal Fluency and Word List Memory test scores.These findings provide further evidence that deficit schizophrenia is a distinct phenotype of schizophrenia, which is characterized by an increased impact of Gram-negative commensal bacteria coupled with a deficit in natural IgM, pointing to aberrations in B1 cells. It is concluded that increased bacterial translocation and deficits in the compensatory immune-regulatory system (CIRS) may drive negative symptoms and neurocognitive impairments, which are hallmarks of deficit schizophrenia.

Preprint ARTICLE | doi:10.20944/preprints202209.0028.v1

The Habits of the Indonesian People by Drinking Coffee with the Incidence of Hypertension

Candra Kusuma Negara, Moses Glorino Rumambo Pandin

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Hypertension; drinking coffee

Online: 2 September 2022 (02:41:17 CEST)

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Preprint REVIEW | doi:10.20944/preprints202105.0317.v1

The Medial Septum as a Potential Target for Treating Brain Disorders Associated with Oscillopathies

Yuichi Takeuchi, Anett Nagy, Lívia Barcsai, Qun Li, Masahiro Ohsawa, Kenji Mizuseki, Antal Berényi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Medial septum; Oscillation; Oscillopathy; Deep brain stimulation; Epilepsy

Online: 14 May 2021 (08:44:10 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202012.0148.v1

Somatic Rhythmic Motion Effective on Peristaltic Circulation of Cerebrospinal Fluid: Hypothesis for Music- and Sport-Based Interventions

Huibing Tan, Torin Chiles, Yinhua Li, Tianyi Zhang, Hangqi Liu, Yunge Jia, Wei Hou, Xinghang Wang, Chenxu Rao, Zichun Wei, Ximeng Xu, Xiaoxin Wen, Siyu Tian

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Music-making; Cerebrospinal fluid; Myodural bridge; Somatic rhythmic motion; CSF-static compartment

Online: 7 December 2020 (12:34:58 CET)

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Preprint REVIEW | doi:10.20944/preprints201905.0326.v1

Monoclonal Antibody as an Emerging Therapies for Ischemic Stroke

Demi Woods, Qian Jiang, Xiang-Ping Chu

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: stroke; antibody therapy; monoclonal antibody; inflammation; acid-sensing ion channel; receptor; growth factors

Online: 28 May 2019 (10:05:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0013.v1

Complexity-Entropy Maps as a Tool for the Characterization of the Clinical Electrophysiological Evolution of Patients Under Pharmacological Treatment with Psychotropic Drugs

Juan M. Diaz, Diego M. Mateos, Carina Boyallian

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: permutation entropy; permutation complexity; pharmacological treatment

Online: 4 August 2017 (11:06:40 CEST)

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Preprint REVIEW | doi:10.20944/preprints201901.0275.v1

The Role of the Gut-Brain Axis in Neurodegenerative Diseases and Relevance of the Canine Model: A Review

Yoko Ambrosini, Dana Borcherding, Anumantha Kanthasamy, Hyun Jung Kim, Albert Jergens, Karin Allenspach, Jonathan Mochel

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: canine enteroid/colonoids; gut-on-a-chip; translational medicine; Alzheimer’s disease; canine cognitive disfunction

Online: 28 January 2019 (10:30:57 CET)

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Preprint ARTICLE | doi:10.20944/preprints202101.0530.v1

Discovery of Simple Blood-Based Test to Predict Early Onset of Alzheimer’s Using Standard Clinical Mass Spectrometry Platforms

Simona Piccirella, Simone Cristoni, Christopher Fowler, James Doecke, Giulia Abate, Daniela Uberti

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; biomarker; prognosis; P53; mass spectrometry

Online: 26 January 2021 (10:01:35 CET)

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Preprint ARTICLE | doi:10.20944/preprints201802.0165.v1

The Importance and Effectiveness of Carotid Endarterectomy in Ischaemic Stroke or TIA with Significant Carotid Stenosis

Muhammad Shohel Almamun, Mobashshereen Khan

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leuco encephalopathy (CADASIL); Carotid Endarterectomy (CEA); Modified Rankin Scale (MRS); Computed Tomography(CT); Tissue plasminogen activator (tPA); Diffusion weighted Imaging (DWI); Recognition of Stroke in the Emergency Room (ROSIER) scale; Magnetic resonance Imaging (MRI); Internal Carotid Artery (ICA)

Online: 26 February 2018 (11:46:47 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0481.v2

A Closer Look into the Role of Protein Tau in the Identification of Promising Therapeutic Targets for Alzheimer’s Disease

Rubayat Islam Khan, Saif Shahriar Rahman Nirzhor, Barnaly Rashid

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: protein tau; Alzheimer’s disease; neurodegenerative disease; synaptic dysfunction; Aβ-peptides; tau-imaging

Online: 27 August 2018 (11:25:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0267.v1

Performance of a Non-Invasive Blood Test for a Conformational Variant of p53 to Predict Alzheimer’s Disease Within 6 Years of Clinical Diagnosis

Simona Piccirella, Daniela Uberti, Chengjie Xiong, Christopher Fowler, James Doecke, Anne Fagan, Giovanni Frisoni, Paul Kinnon

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; AD; blood-based biomarker; p53; unfolded p53; U-p53

Online: 12 May 2021 (11:21:18 CEST)

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Background: Research continues to search for blood-based biomarkers sensitive to Alzheimer’s disease (AD) pathology during the initial stages when symptoms of cognitive decline are not yet apparent. A blood-based biomarker candidate is metalloprotein p53, the conformation of which was previously found to be altered in peripheral cells from individuals with mild cognitive impairment (MCI) and AD, presenting as an unfolded p53 (U-p53) conformational variant. Methods: Plasma samples from the well-characterized Australian Imaging, Biomarkers, and Lifestyle (AIBL) cohort were used to identify the clinically relevant AZ 284^® peptide, specifically present in samples from individuals with symptomatic AD. The AZ 284^® peptide, which is a marker of the U-p53 conformational variant (U-p53^AZ), was identified by immunoprecipitation (IP) with a novel U-p53 conformational variant-specific antibody followed by liquid chromatography (LC) tandem mass spectrometry (MS/MS) and protein sequencing. Using IP-LC surface-activated chemical ionization (SACI) MS/MS analysis, the prognostic and diagnostic performance of U-p53^AZ were examined in the longitudinal AIBL cohort, including 252 plasma samples derived from 214 elderly individuals. For the prognostic analyses, U-p53^AZ levels were assessed at 36, 72, and 90 months after baseline assessment. Results: The prognostic performance of U-p53^AZto predict the progression to AD from preclinical or prodromal AD was high, with area under the receiver operating characteristic curve (AUC) values close to or above 0.90. Furthermore, U-p53^AZ predicted the progression to AD more than 6 years prior to symptom onset with positive and negative predictive values of about 90%. Additionally, the estimated prognostic performance of U-p53^AZ was superior to other main risk factors (i.e., age, sex, and either alone or in combination with amyloid status. Furthermore, U-p53^AZ had high diagnostic performance to differentiate cognitively normal individuals from those with AD (AUC values >0.88). Conclusion: These findings support the use of U-p53^AZ as a prognostic blood-based biomarker accurately predicting the progression to AD dementia during the preclinical and prodromal stages at least 6 years before receiving the clinical diagnosis of AD dementia.

Preprint ARTICLE | doi:10.20944/preprints201907.0345.v1

Classification of Alzheimer's Disease with and without Imagery Using Gradient Boosted Machines and ResNet-50

Lawrence V. Fulton, Diane Dolezel, Jordan Harrop, Yan Yan, Christopher P. Fulton

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s Disease; Extreme Gradient Boosting; Deep Residual Learning; conolutional neural networks; machine learning; dementia

Online: 31 July 2019 (04:33:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints201806.0460.v1

Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact

Rita Moretti, Maria elisa Morelli, Paola Caruso

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: neuro-degeneration; MS; demyelination; vascular disease; stroke; AD; vitamin D-OH 25; VDR; VDH; calcium

Online: 28 June 2018 (05:38:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0196.v1

Quality of Life in Patients with Gluten Neuropathy; Case-Controlled Study

Panagiotis Zis, Ptolemaios Georgios Sarrigiannis, Dasappaiah Ganesh Rao, Marios Hadjivassiliou

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: gluten neuropathy; coeliac disease; gluten free diet; quality of life

Online: 16 April 2018 (08:19:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0018.v2

Effects of Excitatory Repetitive Transcranial Magnetic Stimulation of the P3 Point in Chronic Stroke Patients – Case Reports

Ronaldo Luis da Silva, Angela Maria Costa de Souza, Francielly Ferreira Santos, Sueli Toshie Inoue, Johanne Higgins , Victor Frak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: intraparietal sulcus; stroke; rTMS; Fugl-Meyer Assessment; fast frequency TMS; motricity; sensibility; chronic patients

Online: 17 April 2018 (08:35:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202005.0021.v1

Anti Iglon5 Syndrome: What We Know So Far? A Non-Systematic Review

Caroline Figueiredo da Silva, Gustavo Figueiredo da Silva, Washigton Luiz Gomes de Medeiros Junior, Marcus Vinícius Magno Gonçalves

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: anti-IgLON5 disease; sleep disorders; tau protein accumulation; immunotherapy; neurodegenerative diseases

Online: 2 May 2020 (16:26:03 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202004.0443.v1

The clinical outcome of concurrent speech therapy and transcranial direct current stimulation in dysarthria and palilalia following traumatic brain injury: A case study

Masumeh Bayat, Mahshid Tahamtan, Malihe Sabeti, Mohammad Nami

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: traumatic brain injury (TBI); Dysarthria; transcranial direct current stimulation (tDCS); Quantitative Electroencephalography (QEEG); speech therapy

Online: 24 April 2020 (13:56:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints201907.0265.v2

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

Melvin Hayden

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Aging; Alzheimer’s disease; brain insulin resistance; db/db diabetic mouse model; diabetic cognopathy; insulin resistance; metabolic syndrome; mixed dementia; obesity; type 2 diabetes mellitus

Online: 9 September 2019 (06:12:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202006.0093.v1

Thymic Stromal Lymphopoietin promoted CD4⁺CD25^- T cells differentiation isolated from the thymus of patients with Myasthenia Gravis to CD4⁺CD25⁺ Regulatory T Cells In Vitro

Jiang Yuan, Na Wang, Md Rezaul Karim, Lei Zeng, Qiang Sun, Yanpeng Sun, Hong-Yan Zhang, Yun-Fu Wang

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: myasthenia gravis; thymic stromal lymphopoietin; regulatory T cells; TGF- β; IL-10

Online: 7 June 2020 (15:00:37 CEST)

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Preprint REVIEW | doi:10.20944/preprints201812.0267.v1

Epigenetic Factors in Late-Onset Alzheimer’s Disease: MTHFR and CTH Gene Polymorphisms, Metabolic Trans-sulfuration and Methylation Pathways, and B Vitamins

Gustavo C. Román, Oscar Mancera-Páez, Camilo Bernal

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; CTH gene; DNA methylation; epigenetics; epigenome-wide association study; methylome; MTHFR gene; nutrition; S-adenosylmethionine; vitamin B complex

Online: 24 December 2018 (04:48:53 CET)

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Preprint REVIEW | doi:10.20944/preprints201907.0265.v1

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Obesity, Aging, Intersects and Continuum Of Progression

Melvin R. Hayden

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: aging; Alzheimer’s disease; brain insulin resistance; db/db diabetic mouse model; diabetic cognopathy; insulin resistance; metabolic syndrome; mixed dementia; obesity; type 2 diabetes mellitus

Online: 24 July 2019 (08:05:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202206.0002.v1

Oxygen and the Spark of Human Brain Evolution: a Complex Systems Account

Andrea Luppi, Fernando Rosas, Maryann Noonan, Pedro Mediano, Morten Kringelbach, Robin Carhart-Harris, Emmanuel Stamatakis, Anthony Vernon, Federico Turkheimer

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Human brain evolution; complex systems theory

Online: 1 June 2022 (03:37:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0037.v1

Investigation of Brain Vascular Territories in Stroke Patients Detected Non-Valve Atrial Fibrillation as an Etiological Factor

Mustafa Karaoglan, Serkan Demir

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: brain vessel; ischemic stroke; non-valvular atrial fibrillation

Online: 3 April 2018 (11:07:39 CEST)

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Preprint REVIEW | doi:10.20944/preprints202009.0254.v1

Patient Satisfaction in Medicine and Dentistry: A Need to Advance to a Patient-Reported Outcome Measures (PROMs) Culture in Surgical Sciences

Kelvin I. Afrashtehfar, Mansour K. A. Assery

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: dental care; emotions; health personnel; health services; human needs; motivation; patient reported outcome measures; patient satisfaction; personal satisfaction; theory of satisfaction

Online: 11 September 2020 (09:44:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0355.v1

Prenatal Exposure to Bisphenol A and Phthalates and Behavioral Problems in Children at Preschool Age: The Hokkaido Study on Environment and Children’s Health

Machiko Minatoya, Sachiko Itoh, Keiko Yamazaki, Atsuko Araki, Chihiro Miyashita, Naomi Tamura, Jun Yamamoto, Yu Onoda, kazuki Ogasawara, Toru Matsumura, Reiko Kishi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: SDQ; bisphenol A; phthalates; prenatal exposure; birth cohort; behavioral problems

Online: 27 April 2018 (08:27:38 CEST)

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Preprint REVIEW | doi:10.20944/preprints202201.0098.v1

New Hope for Behavioural and Psychological Symptoms in Dementia (BPSD): A Narrative Review of Clinical Studies Conducted in the Symptomatic Treatments for Agitation and Psychosis Episodes in Alzheimer’s Disease/Dementia

Haider Saddam Qasim, Maree Donna Simpson

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: BPSD; Alzheimer’s dementia; agitation; psychosis; SSRIs; antipsychotics; brexpiprazole; dextromethorphan

Online: 10 January 2022 (11:12:38 CET)

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Background: The psychomotor agitation of the BPSD is one of the common issues in aged care facilities, leading to the poor functional and medical consequences. Psychotropic interventions are the preferable choice of treatment. But which medication should be the prescribers first preference? This review aims to compare pharmacological interventions for psychomotor agitation, judging them according to their effectuality and justifiability profiles. This is to be achieved by retrieving information from RCTs and systematic reviews. Objectives: This review evaluates evidence from RCTs, systematic reviews, and meta-analyses of BPSD patients who had taken agitation treatments. Assessing the efficacy of antidepressants and antipsychotic treatments when compared to each other for the purpose of improving agitation outcomes. Methods: This narrative review includes RCTs and retrospective studies that were comparing one or more active ingredient medications with another or with a placebo, along with sys-tematic reviews comparing antidepressants with antipsychotics such as quetiapine, olanzapine, and risperidone. Studies extracted by searching accessing databases, such as PubMed, OVID, and Cochrane with restrictions of date from 2000 to 2021 and English language. Quality of evidence: The quality of systematic reviews was judged against AMSTAR score, and RCTs were judged according to CONSORT checklist for RCT protocols. Conclusion: There are still few studies of serotonin targeting treatment of agitation in BPSD. The SSRIs such as citalopram were associated with a reduction in symptoms of agitation, and lower risk of adverse effects compared to antipsychotics. This review also illustrates brexpiprazole as a target of multimodal neurotransmitters such as dopamine, serotonin, and norepinephrine; and dextromethorphan, OR dextromethorphan associated with bupropion or quinidine as a blockade of NMDA receptors. The outcome of this review suggests that further studies involving more dementia/Alzheimer’s participants should be conducted. Future studies are required also to assess the long-term safety and efficacy of SSRI, brexpiprazole, dextromethorphan treatments for agitation in BPSD.

Preprint ARTICLE | doi:10.20944/preprints201901.0296.v1

Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia

Thitiporn Supasitthumrong, Chavit Tunvirachaisakul, Daruj Aniwattanapong , Sookjaroen Tangwongchai, Phenphichcha Chuchuen , Itthipol Tawankanjanachot , Thiti Snabboon, Solaphat Hemrungrojn , Andre F. Carvalho, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: episodic memory, apolipoprotein, dementia, biomarkers, anion gap, inflammation

Online: 29 January 2019 (16:52:14 CET)

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Preprint CASE REPORT | doi:10.20944/preprints201805.0146.v2

Growth Hormone (GH) Administration Increases the Metabolic Activity of the Left Hippocampus in an Elder Patient with Cognitive Disorders

Jesús Devesa, Iria Núñez, Carlos Agra, Alejandro Bejarano, Pablo Devesa

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Growth Hormone; cognition; recent memory; PET-SCAN; hippocampus; amygdala; parahippocampus; ApoE genotype.

Online: 5 June 2018 (15:18:11 CEST)

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Preprint HYPOTHESIS | doi:10.20944/preprints202004.0215.v1

The Role of Endocannabinoid System in Sleep Deprivation-Induced Psychosis-Like Symptoms through Hampering Prepulse Inhibition; A Hypothesis

Mohammad Nami, Ali-Mohammad Kamali, Milad Kazemiha, Rao kosagisharaf, Sabri Derman

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: endocanabinoid system; sleep deprivation; animal models; psychosis-like symptoms; drug development

Online: 14 April 2020 (06:28:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0371.v1

Effect of Resveratrol on Reactive Oxygen Species-Induced Cognitive Impairment in Rats with Angiotensin II-Induced Early Alzheimer’s Disease

Yu-Te Lin, Yi-Chung Wu, Gwo-Ching Sun, Chiu-Yi Ho, Tzyy-Yue Wong, Ching-Huang Lin, Hsin-Hung Chen, Tung-Chen Yeh, Chia-Jung Li, Ching-Jiunn Tseng, Pei-Wen Cheng

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Alzheimer’s disease; central nervous system; hypertension; brain-derived neurotrophy factor; NADPH oxidase

Online: 21 August 2018 (06:04:03 CEST)

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Preprint REVIEW | doi:10.20944/preprints202211.0177.v1

Monoclonal Antibodies Against Calcitonin Gene-related Peptide for Migraine Prophylaxis: A Systematic Review of Real-world Data

Antun Pavelic, Christian Wöber, Franz Riederer, Karin Zebenholzer

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Real-world; Erenumab; Galcanezumab; Fremanezumab; Eptinezumab; pharmacoepidemiology; effectiveness; tolerability; safety; treatment pause; switching

Online: 9 November 2022 (11:51:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202012.0322.v1

Hydrocephalus Revisited: New Insights Into Dynamics of Neurofluids on Macro- and Microscales

Hans Ludwig, Christoph Bock, Jutta Gärtner, Stina Schiller, Jens Frahm, Steffi Dreha-Kulaczewski

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Cerebrospinal fluid; real-time MRI; hydrocephalus; space flight disease; aquaporin; spontaneous intracranial hypotension; neural tube defect

Online: 14 December 2020 (10:21:21 CET)

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Preprint ARTICLE | doi:10.20944/preprints202107.0014.v1

Using a Combination of Electroencephalographic and Acoustic Features to Accurately Predict Emotional Responses to Music

Devon Krish

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: EEG; music therapy; acoustic features; machine learning; emotional-response predictions

Online: 1 July 2021 (11:12:19 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201812.0210.v1

Common Connectivity Phenotypes in Rapid Eye Movement Sleep Behavior Disorder and Parkinson’s Disease: The Search for an Intermediate Phenotype

Craig A. Moodie, Kelvin O. Lim, Bryon A. Mueller, Laura S. Hemmy, Michael J. Howell, Paul J. Tuite

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Parkinson’s; RBD; connectivity; phenotype; classification; network

Online: 18 December 2018 (03:58:08 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0018.v1

Effects of Excitatory Transcranial Magnetic Stimulation of the Anterior Intraparietal Area in Chronic Stroke Patients

Ronaldo Luis da Silva, Angela Maria Costa de Souza, Francielly Ferreira Santos, Sueli Toshie Inoue, Johanne Higgins , Victor Frak

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: anterior intraparietal area; stroke; rTMS; Fugl-Meyer Assessment; fast frequency TMS; motricity; sensibility; chronic patients

Online: 2 March 2018 (05:16:16 CET)

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Preprint REVIEW | doi:10.20944/preprints201807.0631.v1

Opportunities and Challenges for Single-Unit Recordings from Enteric Neurons in Awake Animals

Bradley Barth, Hsin-I Huang, Gianna Hammer, Xiling Shen

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: microelectrodes; in vivo electrophysiology; neural interfaces; enteric nervous system; conscious recording; electrode implantation

Online: 31 July 2018 (22:34:34 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202008.0669.v1

A case of Miller fisher’s Syndrome Presenting with Dysphagia and Nasal Voice

Leila Tamaoui, Mounia Rahmani, Hajar Touati, leila Errguig, Maria Benabdeljlil, Sadia Aidi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Miller Fisher Syndrome; Guillain Barré Syndrome variant; Dysphonia; Dysphagia

Online: 30 August 2020 (14:41:29 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202211.0153.v1

Successful Treatment With Minocycline and Saiko-Keishi-to for Covid-19-Associated CNS Lesion

Masashi Ohe, Shida Haruki, Junya Yamamoto, Masahide Seki, Ken Furuya

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: COVID-19; minocycline; saiko-keishi-to

Online: 8 November 2022 (10:28:06 CET)

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Preprint ARTICLE | doi:10.20944/preprints201805.0070.v1

Inhaled Xenon Washout as a Biomarker of Alzheimer’s Disease

Francis T. Hane, Tao Li, Jennifer Anne Plata, Ayman Hassan, Karl Granberg, Mitchell S. Albert

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Hyperpolarized gas MRI; xenon; gas retention; Alzheimer’s disease; wash out; vascular

Online: 3 May 2018 (12:02:44 CEST)

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Preprint REVIEW | doi:10.20944/preprints201912.0261.v1

Therapeutics Advancement for Huntington Disease

Ashok Kumar, Vijay Kumar, Kritanjali Singh, You-Sam Kim, Yun-Mi Lee, Jong-Joo Kim

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: huntington disease; cag repeat; mutant huntingtin (mhtt); therapeutics; neurodegeneration

Online: 19 December 2019 (13:18:38 CET)

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Preprint INTERESTING IMAGES | doi:10.20944/preprints202309.0612.v1

Encephalomalacia in a Young Adult: A Rare Presentation

Pallavi Harjpal, Irshad Qureshi

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: Encephalomalacia; gliosis; cerebral softening; stroke

Online: 11 September 2023 (09:37:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202005.0122.v1

Impaired Social Skills as a Key Component of Clinical Depression: Associations with Severity of Illness, Self-Esteem, Family Functional Health Satisfaction, and Personality Features

Pitima Kurimoto, Peeraphon Lueboonthavatchai, Michael Maes

Subject: Medicine And Pharmacology, Neuroscience And Neurology Keywords: social skill deficits; major depression; stress; state marker; introvert personality; family supporting satisfaction

Online: 7 May 2020 (12:37:06 CEST)

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Medicine and Pharmacology