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Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Fabric Phase Sorptive Extraction (FPSE); sol-gel; phenols; environmental pollution; sample preparation; microextraction

Online: 19 January 2017 (02:21:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0075.v3

A Robust Liquid Chromatographic Method for Confirmation of Drug Stability of Azithromycin in Bulk Samples, Tablets and Suspensions

Alex O. Okaru, Kennedy O. Abuga, Franco N. Kamau, Stanley N. Ndwigah, Dirk W. Lachenmeier

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: azithromycin; HPLC; robust; isocratic; drug stability; degradation products

Online: 4 January 2017 (10:08:52 CET)

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Preprint REVIEW | doi:10.20944/preprints201909.0020.v1

Phytoremediation of Polluted Waterbodies with Aquatic plants: Recent Progress on Heavy Metal and Organic Pollutants

Enyoh Christian, Isiuku Beniah

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chemical pollutants; chemometrics; constructed wetlands; hydroponics; macrophytes; models; toxicity; water pollution

Online: 2 September 2019 (09:45:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0036.v1

Electrochemical Detection of Dopamine Using 3D Porous Graphene Oxide/Gold Nanoparticle Composites

Sung-Sik Choo, Ee-Seul Kang, Inbeom Song, Dong-Hyun Lee, Jeong-Woo Choi, Tae-Hyung Kim

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: graphene oxide; porous structure; gold nanoparticles; indium tin oxide, neurotransmitters, dopamine, composites, electrochemical detection

Online: 6 April 2017 (16:49:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0084.v2

Quantitative Detection of Trace Malachite Green in Aquiculture Water Samples by Extractive Electrospray Ionization Mass Spectrometry

Xiaowei Fang, Shuiping Yang, Konstantin Chingin, Liang Zhu, Xinglei Zhang, Zhiquan Zhou, Zhanfeng Zhao

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: extractive electrospray ionization; rapid detection; malachite green; water; mass spectrometry

Online: 11 August 2016 (10:00:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0080.v1

M-Polynomials and Topological Indices of Titania Nanotubes

Shin Min Kang, Mobeen Munir, Abdul Rauf Nizami, Shazia Rafique, Waqas Nazeer

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: degree-based topological index; Zagreb index; general Randic index; symmetric division index; M-polynomial, titania nanotubes

Online: 19 October 2016 (12:44:36 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints201610.0106.v1

A Validated HPLC Method for the Determination of Vanillyl Butyl Ether in Cosmetic Preparations

Antonio Alberola, Francisco Trigo, Joaquin Melendez, Gema Muedra

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: vanillyl butyl ether; HPLC; method validation; cosmetic product

Online: 25 October 2016 (09:43:18 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201608.0076.v1

Electrochemical Behavior and Determination of Chlorogenic Acid Based on Carbon Nanotubes Modified Screen-Printed Electrode

Xiao-Yan Ma, Hong-Qiao Yang, Hua-Bing Xiong, Xiao-Fen Li, Jing-Ting Gao, Yun-Tao Gao

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Chlorogenic acid; screen-printed electrode; carbon nanotubes

Online: 8 August 2016 (12:07:57 CEST)

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Preprint REVIEW | doi:10.20944/preprints201609.0015.v1

Current Research on the Speciation and Determination of Mercury in Different Environmental Matrices Using Various Analytical Instruments

Lakshmi Narayana Suvarapu, Sung-Ok Baek

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: speciation; mercury; analytical instruments; speciation; environmental samples

Online: 5 September 2016 (10:43:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0041.v1

Some Computational Aspects of Triangular Boron Nanotubes

Mobeen Munir, Waqas Nazeer, Shazia Rafique, Abdul Rauf Nizami, Shin Min Kang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: M-polynomial; degree-based index; boron nanotubes

Online: 7 November 2016 (07:41:36 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0023.v1

A Novel Method for Multiple Mycotoxins Analysis in Feedstuffs by Flow-Through Cartridge Purification and Ultra-High-Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry

Rui-guo Wang, Xiao-ou Su, Zhang Wei, Pei-long Wang, Zhi-qi Zhang, Ai-bo Wu, Chuan-min Cheng, Yan Xue, Yu Li

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: UPLC-MS/MS; mycotoxins; feedstuffs; flow-through; multiple analysis

Online: 5 December 2016 (09:40:24 CET)

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Preprint REVIEW | doi:10.20944/preprints201908.0260.v1

Microplastic-Toxic Chemical Interaction: A Review Study on Quantified Levels, Mechanism and Implication

Verla Andrew Wirnkor, Enyoh Christian Ebere, Verla Evelyn Ngozi, Nwanorh Kieran Oharley

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: air pollution; micropollutants; plastic debris; risks; soil pollution; toxicity; water pollution

Online: 26 August 2019 (01:39:10 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0362.v1

Optimization of Time-Weighted Average Air Sampling by Solid-Phase Microextraction Fibers Using Finite Element Analysis Software

Bulat Kenessov, Jacek A. Koziel, Nassiba Baimatova, Olga P. Demyanenko, Miras Derbissalin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: solid-phase microextraction; air sampling; air analysis; volatile organic compounds; COMSOL; time-weighted average

Online: 19 September 2018 (04:08:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201610.0090.v1

Fatty Acids Profiles of Stipe and Blade from the Norwegian Brown Macroalga Laminaria hyperborea, Using Off-Line SPE and GC-MS

Lena Oksdøl Foseid, Hanne Devle, Yngve Stenstrøm, Carl Fredrik Naess-Andresen, Dag Ekeberg

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Laminaria hyperborean; lipids; fatty acids; GC-MS

Online: 21 October 2016 (08:59:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0001.v2

Effects of Continuous Deep Fat Frying on the Physical and Chemical Properties of Assorted Brands of Edible Cooking Oils Sold in Metropolitan Kampala

Timothy Omara, Erisa Kigenyi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: color; free fatty acids; iodine absorption value; paraanisidine value; peroxide value

Online: 6 February 2019 (06:36:41 CET)

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Preprint ARTICLE | doi:10.20944/preprints201703.0047.v1

Detection of 17 β-estradiol in Environmental Estrogen Pollution and in Women’s Health Care Using a Single-Use, Cost Effective Biosensor Based on Differential Pulse Voltammetry (DPV)

Yifan Dai, Chung chiun Liu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: 17 β-estradiol; estrogen pollution; female reproduction; DPV

Online: 8 March 2017 (05:39:59 CET)

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Preprint ARTICLE | doi:10.20944/preprints201612.0038.v1

Chemical Fingerprint Analysis and Quantitative Analysis of Rosa Rugosa by UPLC-DAD

Sanawar Mansur, Rahima Abdullab, Amatjan Ayubicb, Haji Akbar Aisa

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Rosa rugosa; UPLC-DAD; quality control; fingerprint

Online: 7 December 2016 (11:11:00 CET)

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Preprint REVIEW | doi:10.20944/preprints202111.0546.v1

Review on Chemical Graph Theory and Its Application in Computer-Assisted Structure Elucidation

Mehmet Aziz Yirik, Kumsal Ecem Colpan, Saskia Schmidt, Maria Sorokina, Christoph Steinbeck

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chemical graph theory; computational chemistry; CASE; computer-assisted structure elucidation

Online: 29 November 2021 (15:35:43 CET)

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Preprint REVIEW | doi:10.20944/preprints201706.0108.v1

Application of Carbon Nanotubes in Chiral and Achiral Separations of Pharmaceuticals, Biologics and Chemicals

Ayman Hemasa, Nenad Naumovski, William A. Maher, Ashraf Ghanem

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: carbon nanotubes; chiral separation; achiral separation; SWCNTs; MWCNTs

Online: 23 June 2017 (03:30:13 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202010.0486.v1

Carnosine to Combat Novel Coronavirus (nCoV, COVID-19): Molecular Docking and Modeling to Co-Crystallized Host Angiotensin-Converting Enzyme 2 (ACE2) and Viral Spike Protein

Loai M. Saadah, Ghina’a I Abu Deiab, Qosay Al-Balas, Iman A. Basheti

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: COVID-19; carnosine; angiotensin-converting enzyme 2 (ACE2); practitioner; molecular docking; modeling

Online: 23 October 2020 (10:44:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201704.0188.v1

The Investigation of Electrochemistry Behaviors of Tyrosinase Based on Directly Electrodeposited Graphene on Choline–Gold Nanoparticals

Yaping He, Xiaohui Yang, Quan Han, Jianbin Zheng

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: electrochemistry; tyrosinase; graphene; Choline–gold nanoparticals; catechol

Online: 28 April 2017 (05:25:54 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201801.0213.v1

Identification of Bichalcones as Sirtuin Inhibitors by Virtual Screening and in Vitro Testing

Berin Karaman, Zayan Alhalabi , Sören Swyter, Shetonde O. Mihigo, Kerstin Andrae-Marobela, Manfred Jung , Wolfgang Sippl , Fidele Ntie-Kang

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: bichalcones; sirtuin inhibitors; virtual screening

Online: 23 January 2018 (09:12:43 CET)

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Preprint REVIEW | doi:10.20944/preprints201908.0316.v1

Airborne Microplastics: A Review Study on Method for Analysis, Occurrence, Movement and Risks

Enyoh Christian Ebere, Verla Andrew Wirnkor, Verla Evelyn Ngozi, Ibe Francis Chizoruo, Amaobi Collins Emeka

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: air pollution; dermal route; fibers; health risk; inhalation; micropollutants

Online: 30 August 2019 (05:08:43 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201611.0075.v1

A Robust Liquid Chromatographic Method for the Analysis of Azithromycin in Bulk Samples, Tablets and Suspensions

Alex O. Okaru, Kennedy O. Abuga, Franco N. Kamau, Stanely N. Ndwigah, Dirk W. Lachenmeier

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: azithromycin; HPLC; robust; isocratic; degradation products

Online: 14 November 2016 (07:57:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201707.0086.v1

Development of a Rapid Method for the Determination of Caffeine in Coffee Grains by GC-FID-A Fully Validated Approach

Ioannis Pasias, Ioannis Kyriakou, Charalampos Proestos

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Caffeine, Uncertainty calculation; ISO 17025, Guatemala coffee grains; GC-FID

Online: 28 July 2017 (13:05:43 CEST)

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Preprint REVIEW | doi:10.20944/preprints202103.0419.v1

Role of Resveratrol in Prevention and Control of Cardiovascular Disorders and Cardiovascular Complications Related to Covid-19 Disease: Mode of Action and Approaches Explored to Increase Its Bioavailability

Nikola Gligorijević, Dragana Stanić-Vučinić, Mirjana Radomirović, Marija Stojadinović, Olgica Nedic, Urmila Khulal, Tanja Ćirković Veličković

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Resveratrol; Cardiovascular disease; Bioavailability; Diet; COVID-19; Resveratrol carriers; Cardiovascular protection

Online: 16 March 2021 (12:00:17 CET)

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Preprint CASE REPORT | doi:10.20944/preprints202101.0059.v1

Plastic Pollution Recycling: A Case Study of First Marine Protected Area of Pakistan (Astola Island)

Misbah Younis, Uzaira Rafique, Asma Jabeen, Faisal Baloch

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Astola Island; plastic pollution; Zeolite catalyst; recycling

Online: 4 January 2021 (16:23:56 CET)

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Preprint ARTICLE | doi:10.20944/preprints201608.0084.v1

Quantitative detection of trace malachite green in aquiculture water samples by extractive electrospray ionization mass spectrometry

Xiaowei Fang, Shuiping Yang, Konstantin Chingin, Liang Zhu, Xinglei Zhang, Zhiquan Zhou, Zhanfeng Zhao

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: extractive electrospray ionization; rapid detection; malachite green; water; mass spectrometry

Online: 8 August 2016 (14:58:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0176.v2

A Novel Protocol to Monitor Trace Levels of Selected Polycyclic Aromatic Hydrocarbons in Environmental Water Using Fabric Phase Sorptive Extraction Followed by High Performance Liquid Chromatography-Fluorescence Detection

Shivender Singh Saini, Abuzar Kabir, Avasarala Lakshmi Jagannadha Rao, Ashok Kumar Malik, Kenneth G. Furton

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Fabric Phase Sorptive Extraction (FPSE); Polycyclic Aromatic Hydrocarbons (PAHs); Persistent pollutants; Green Analytical Chemistry (GAC); Environmental water; Sorptive microextraction

Online: 19 April 2017 (19:27:27 CEST)

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Fabric phase sorptive extraction (FPSE) combines the advanced material properties of sol–gel derived microextraction sorbents and the flexible and permeable fabric support to create a robust, simple and green sample preparation device. It simultaneously improves the extraction sensitivity, and the speed of the extraction by incorporating high volume of sponge-like porous sol–gel hybrid inorganic–organic sorbents into permeable fabric substrates that is capable of extracting target analytes directly from simple to complex aqueous sample matrices. For the first time, this technique was applied to the trace level determination of selected polycyclic aromatic hydrocarbons (PAHs) in environmental water samples using a non-polar sol–gel C18 coated FPSE media. Several extraction parameters were optimized to improve extraction efficiency and to achieve high detection sensitivity. Validation tests of spiked samples showed good linearity for four selected PAHs (R² = 0.9983–0.9997) over a wide range of concentrations (0.010-10 ng/mL). Limits of detection (LODs) and quantification (LOQs) were measured at pg/mL levels, 0.1–1 pg/mL and 0.3–3 pg/mL, respectively. Inter- and intra-day precision tests showed variations of 1.1–4.1% for four selected PAHs. Average absolute recovery values were in the range of 88.1–90.5% surpassed the recovery prediction model, with relative standard deviations below 5%. The developed FPSE-HPLC-FLD protocol was finally applied to analyze 8 environmental water samples. Out of four selected PAHs, fluoranthene (Flu) and phenanthrene (Phen) were the most frequently detected in four samples, at concentration levels of 5.6–7.7 ng/mL and 4.1-11 ng/mL, respectively followed by anthracene (Anth) and pyrene (Pyr) in two samples. The newly developed FPSE-HPLC-FLD protocol is simple, green, fast and economical, with adequate sensitivity for trace levels of four selected PAHs and seems to be promising in routine monitoring of water quality and safety.

Preprint ARTICLE | doi:10.20944/preprints201812.0216.v2

Platinum and Rhodium in Potatoes Samples by Using Voltammetric Techniques

Santino Orecchio, Diana Amorello

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Potatoes; Platinum; Rhodium; Voltammetry

Online: 22 January 2019 (17:54:09 CET)

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Preprint ARTICLE | doi:10.20944/preprints201902.0001.v1

Effects of Continuous Deep Fat Frying on the Physical and Chemical Properties of Assorted Brands of Edible Cooking Oils Sold in Metropolitan Kampala

Timothy Omara, Erisa Kigenyi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: color; free fatty acids; fries; iodine absorption value; Kampala; paraanisidine value; peroxide value

Online: 1 February 2019 (03:53:04 CET)

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Preprint ARTICLE | doi:10.20944/preprints201611.0075.v2

A Robust Liquid Chromatographic Method for the Analysis of Azithromycin in Bulk Samples, Tablets and Suspensions

Alex O. Okaru, Kennedy O. Abuga, Franco N. Kamau, Stanely N. Ndwigah, Dirk W. Lachenmeier

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: azithromycin; HPLC; robust; isocratic; degradation products

Online: 29 December 2016 (07:24:43 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0106.v2

The Discovery of Synthetic Proteolytic Peptide

Rina Nakamura, Motomi Konishi, Masanari Taniguchi, Yusuke Hatakawa, Toshifumi Akizawa

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: catalytide; serine protease-like peptide; Tob1

Online: 17 January 2018 (07:27:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints202104.0038.v1

Synthesis of ZnO Nanoparticles by Using Rosmarinus officinalis Extract and Their Application for Methylene Bleu and Crystal Violet Dyes Degradation under Sunlight Irradiation

Tahani Al-Garni, Naaser A.Y. Abduh, Abdullah Al-Kahtani, Ahmed Aouissi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: dye; ZnO; NPs; leaf extract; Rosmarinus officinalis; photodegradation; methylene bleu; crystal violet

Online: 2 April 2021 (08:11:51 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201701.0085.v2

Fabric Phase Sorptive Extraction Explained

Abuzar Kabir, Rodolfo Mesa, Jessica Jurmain, Kenneth Furton

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: fabric phase sorptive extraction (FPSE); sol-gel; phenols; environmental pollution; sample preparation; microextraction; green analytical chemistry (GAC)

Online: 10 May 2017 (04:37:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0103.v1

Wearable Enzymatic Alcohol Biosensor

Bob Lansdorp, William Ramsay, Rashad Hamid, Evan Strenk

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: alcohol; biosensor; cartridge; disposable; transdermal; Alcohol Use Disorder

Online: 8 April 2019 (15:07:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0225.v1

Selective Colorimetric Sensors for Cyanide and Acetate Ion in Partially Aqueous Medium

Divya Singhal, Neha Gupta, Ashok Kumar Singh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chemosensors; CN− selective sensor; test strip sensor

Online: 27 March 2018 (12:13:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201902.0016.v1

Simultaneous Determination of Pharmaceuticals by Solid-phase Extraction and Liquid Chromatography–tandem Mass Spectrometry: A Case Study from Sharjah Sewage Treatment Plant

Mohammad H. Semreen, Abdallah Shanableh, Lucy Semerjian, Hasan Alniss, Muath Mousa, Xuelian Bai, Kumud Acharya

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: liquid chromatography–tandem mass spectrometry; pharmaceuticals; wastewater analysis; solid phase extraction

Online: 2 February 2019 (03:21:04 CET)

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Preprint REVIEW | doi:10.20944/preprints202106.0350.v1

A Review on Green Synthesis and Biological Activities of Nitrogen and Oxygen Containing Heterocycles

Susheel Gulati, Rajvir Singh, Suman Sangwan

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Heterocycles; Coumarins; Dihyfropyrimidinones; Imidazoles; Isoxazoles; Benzimidazoles; Green Chemistry

Online: 14 June 2021 (10:39:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0258.v1

Rapid Monitoring of Organochlorine Pesticides Residues in Various Fruit Juices and Water Samples Using Fabric Phase Sorptive Extraction and Gas Chromatography-Mass Spectrometry

Ramandeep Kaur, Ripneel Kaur, Susheela Rani, Ashok Kumar Malik, Abuzar Kabir, Kenneth G. Furton, Victoria Samanidou

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Fabric phase sorptive extraction; Gas chromatography-Mass Spectrometry; Organochlorine pesticides; Sample preparation

Online: 25 January 2019 (14:56:26 CET)

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Preprint ARTICLE | doi:10.20944/preprints202103.0652.v1

Influence of Chitosan-Based Edible Coating on the Shelf Life and Nutritional Quality of Guava (Psidium guajava L.) Fruit in Room and Refrigerated Temperatures

Areeqa Shamshad, shahzad Zafar Iqbal, Ahmad Faizal Abdull Razis, Sunusi Usman, Nada Basheir Ali, Amna Mumtaz, Muhammad Rafique Asi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chitosan coating; edible coating; guava fruit; shelf-life; HPLC; flavonoids

Online: 26 March 2021 (10:12:24 CET)

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Preprint REVIEW | doi:10.20944/preprints202108.0383.v1

Carotenoids in Bacteria: Biosynthesis, Extraction, Characterization and Applications

Gerson-Dirceu López, Gerardo Álvarez-Rivera, Chiara Carazzone, Elena Ibañez, Chad Leidy, Alejandro Cifuentes

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Bacterial carotenoids; Cell disruption; HPLC separation; MS analysis; Food and textile applications

Online: 18 August 2021 (14:09:35 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202101.0059.v2

Recycling of Plastic Waste by Using Pyrolysis Reactor: A Case Study of First Marine Protected Area of Pakistan (Astola Island)

Misbah Youngish, Uzaira Rafique, Asma Jabeen, Faisal Baloch

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Astola Island; plastic pollution; Zeolite catalyst; recycling

Online: 6 January 2021 (15:34:11 CET)

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Preprint REVIEW | doi:10.20944/preprints202105.0567.v1

Artificial Intelligence and Machine Learning in Medicinal Chemistry and Validation of Emerging Drug Targets

Sameer Quazi, Rohit Jangi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Artificial intelligence AI; machine learning; algorithms; QSAR; drug discovery

Online: 24 May 2021 (13:02:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0321.v1

Modeling Solid-Phase Microextraction of Volatile Organic Compounds by Porous Coatings Using Finite Element Analysis

Bulat Kenessov, Miras Derbissalin, Jacek A. Koziel, Dmitry S. Kosyakov

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: SPME; Carboxen; volatile organic compounds; benzene; transport in porous media; COMSOL Multiphysics

Online: 31 January 2019 (07:08:17 CET)

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Preprint ARTICLE | doi:10.20944/preprints202010.0181.v1

Determination of Aflatoxin M1 in Raw Cow's Milk by Using HPLC-FLD, in Injibara Town, Awi Zone, Amhara, Ethiopia

Adisie Kassa, Alemu Talema, Getasew Ketsela

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Ethiopia; milk; aflatoxin; Awi zone; HPLC-FLD; Aspergillus

Online: 8 October 2020 (15:53:52 CEST)

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Preprint REVIEW | doi:10.20944/preprints201801.0120.v1

Responsive Polydiacetylene Vesicles for Biosensing Microorganisms

Estelle Lebègue, Carole Farre, Catherine Jose, Joelle Saulnier, Florence Lagarde, Yves Chevalier, Carole Chaix, Nicole Jaffrezic-Renault

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: vesicles; polydiacetylene; biosensing; bacteria; toxins; virus; peptides

Online: 15 January 2018 (07:44:02 CET)

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Preprint ARTICLE | doi:10.20944/preprints202011.0586.v1

Chemical Compositions and Antioxidant Activities of Indonesian Citrus Essential Oils and Their Elucidation Using Principal Component Analysis

Euis Julaeha, Kristin Shinta Dewi, Mohamad Nurzaman, Tatang Wahyudi, Tati Herlina, Ari Hardianto

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chemical composition; antioxidant; Citrus; essential oils; Principal Component Analysis.

Online: 23 November 2020 (14:19:03 CET)

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Preprint ARTICLE | doi:10.20944/preprints201912.0416.v1

Design of Multiplex Lateral Flow Tests: A Case Study for Simultaneous Detection of Three Antibiotics

Anastasiya V. Bartosh, Dmitriy V. Sotnikov, Olga D. Hendrickson, Anatoly V. Zherdev, Boris B. Dzantiev

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: multiparametric assay; rapid tests; immunochromatography; antibiotics; non-equilibrium interactions

Online: 31 December 2019 (16:25:33 CET)

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Preprint ARTICLE | doi:10.20944/preprints201907.0055.v1

Effects of Time, Temperature, and Solvent Ratio on the Extraction of Non-Extractable Polyphenols with Anticancer Activity of Barhi Date Palm Kernels Extracts Using Response Surface Methodology

Israa Mahmud, Mohamed E. S. Mirghani, Faridah Yusof, Ma'an Al-khatib

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Barhi date palm kernels (BDPK); non-extractable polyphenols (NEPP); anticancer activity; antioxidant activity; response surface methodology; optimisation.

Online: 3 July 2019 (09:23:01 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0269.v1

Evaluating the Adsorbed Water Layer on Polar Stationary Phases for Hydrophilic Interaction Chromatography (HILIC)

Yong Guo, Nidhi Bhalodia, Bassel Fattal, Ioannis Serris

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: volume ratio; adsorbed water layer; stationary phase; salt concentration; column temperature

Online: 28 January 2019 (08:31:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints201801.0022.v1

Development of Phaleria macrocarpa (Scheff.) Boerl Fruits Using Response Surface Methodology On Phenolic, Flavonoid and Antioxidants Properties

Khurul Ain Mohamed Mahzir, Siti Salwa Abdul Gani, Nor Fadzillah Mokhtar

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Phaleria macrocarpa; extraction; free radical scavenging activity (DPPH); ferric ion reducing power assay (FRAP); total phenolic content (TPC); total flavonoid content (TFC); response surface methodology (RSM)

Online: 3 January 2018 (10:15:16 CET)

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Preprint ARTICLE | doi:10.20944/preprints201804.0309.v1

Development of a Fabric Phase Sorptive Extraction-High Performance Liquid Chromatography-Ultraviolet Detection Method for the Analysis of Phenyltin Compounds in Environmental Water and Canned Food Samples

Heena N/A, Ashok Kumar Malik, Abuzar Kabir, Kenneth G. Furton

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: phenyltin derivatives; tetraphenyltin; triphenyltin chloride; triphenyltin acetate; triphenyltin hydroxide; fabric phase sorptive extraction (FPSE), high performance liquid chromatography (HPLC)

Online: 24 April 2018 (07:45:23 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202101.0440.v1

Comprehensive Identification of Glycosphingolipids in Human Plasma using Hydrophilic Interaction Liquid Chromatography – Electrospray Ionization Mass Spectrometry

Michal Holčapek, Karel Hořejší, Robert Jirásko, Michaela Chocholoušková, Denise Wolrab, David Kahoun

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: glycosphingolipids; lipidomics; mass spectrometry; hydrophilic interaction liquid chromatography; human plasma; lipid profile; sample preparation; fragmentation behavior

Online: 22 January 2021 (11:31:39 CET)

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Preprint ARTICLE | doi:10.20944/preprints202306.1846.v1

Metabolome Mining of Curcuma longa L. Using HPLC-MS/MS and Molecular Networking

Rabin Budhathoki, Arjun Prasad Timilsina, Bishnu P. Regmi, Khaga Raj Sharma, Niraj Aryal, Niranjan Parajuli

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Untargeted metabolomics; HPLC-ESI-MS/MS; Curcuma longa; GNPS; Diarylheptanoids

Online: 27 June 2023 (04:47:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201904.0205.v1

Preactivation Crosslinking – An Efficient Method for the Oriented Immobilization of Antibodies

Barbara Schroeder, Hoa Le Xuan, Jule L. Völzke, Michael G. Weller

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: antibody coating; proximity-enhanced reaction; immunoglobulins; IgG; protein A; protein G; bio-interaction; immunoprecipitation; pull-down assay; immunocapture; stabilization; yield; regeneration; nanoparticles; microparticles; biochips; immunosensor; photochemical crosslinker; click chemistry; herceptin; trastuzumab

Online: 18 April 2019 (07:55:11 CEST)

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Preprint TECHNICAL NOTE | doi:10.20944/preprints202009.0683.v1

A Novel DNA Extraction Protocol from Frozen Blood of Normal Individuals and Patients Who Received Systemic Chemotherapy

Hayder O. Hashim, Mohammed Baqur S. Al-Shuhaib

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: DNA extraction; normal; patients; protocol; frozen blood

Online: 28 September 2020 (10:52:59 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201703.0176.v1

A Novel Protocol to Monitor Trace Levels of Selected Polycyclic Aromatic Hydrocarbons in Environmental Water Using Fabric Phase Sorptive Extraction Followed by High Performance Liquid Chromatography-Fluorescence Detection

Shivender Singh Saini, Abuzar Kabir, Ashok Kumar Malik, Avasarala Lakshmi Jagannadha Rao, Kenneth Furton

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: fabric phase sorptive extraction (FPSE); polycyclic aromatic hydrocarbons (PAHs); persistent pollutants; green analytical chemistry (GAC); environmental water; sorptive microextraction

Online: 22 March 2017 (17:47:16 CET)

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Fabric phase sorptive extraction (FPSE) combines the advanced material properties of sol–gel derived microextraction sorbents and the flexible and permeable fabric support to create a robust, simple and green sample preparation device. It simultaneously improves the extraction sensitivity, and the speed of the extraction by incorporating high volume of sponge-like porous sol–gel hybrid inorganic–organic sorbents into permeable fabric substrates that is capable of extracting target analytes directly from simple to complex aqueous sample matrices. For the first time, this technique was applied to the trace level determination of selected polycyclic aromatic hydrocarbons (PAHs) in environmental water samples using a non-polar sol–gel C18 coated FPSE media. Several extraction parameters were optimized to improve extraction efficiency and to achieve high detection sensitivity. Validation tests of spiked samples showed good linearity for four selected PAHs (R² = 0.9983–0.9997) over a wide range of concentrations (0.010-10 ng/mL). Limits of detection (LODs) and quantification (LOQs) were measured at pg/mL levels, 0.1–1 pg/mL and 0.3–3 pg/mL, respectively. Inter- and intra-day precision tests showed variations of 1.1–4.1% for four selected PAHs. Average absolute recovery values were in the range of 88.1–90.5% surpassed the recovery prediction model, with relative standard deviations below 5%. The developed FPSE-HPLC-FLD protocol was finally applied to analyze 8 environmental water samples. Out of four selected PAHs, fluoranthene (Flu) and phenanthrene (Phen) were the most frequently detected in four samples, at concentration levels of 5.6–7.7 ng/mL and 4.1-11 ng/mL, respectively followed by anthracene (Anth) and pyrene (Pyr) in two samples. The newly developed FPSE-HPLC-FLD protocol is simple, green, fast and economical, with adequate sensitivity for trace levels of four selected PAHs and seems to be promising in routine monitoring of water quality and safety.

Preprint ARTICLE | doi:10.20944/preprints201711.0074.v1

Cuprous Oxide Thin Film Non-Enzymatic Glucose Sensor Using Differential Pulse Voltammetry (DPV) and Other Voltammetry Methods and Comparing to Different Thin Film Electrodes on the Detection of Glucose in an Alkaline Solution

Yifan Dai, Alireza Molazemhosseini, Kevin Abbasi, Chung Chiun Liu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: cuprous oxide; non-enzymatic glucose sensor; alkaline solution; differential pulse voltammetry

Online: 13 November 2017 (03:15:30 CET)

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Preprint ARTICLE | doi:10.20944/preprints201803.0209.v1

MS/MS-Guided Isolation of Clarinoside, a New Anti-Inﬂammatory Pentalogin Derivative

Coralie Audoin, Adam Zampalégré, Natacha Blanchet, Alexandre Giuliani, Emmanuel Roulland, Olivier Laprévote, Grégory Genta-Jouve

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Mitracarpus scaber Zucc.; pentalogin; anti-inﬂammatory; MS/MS; Il-8

Online: 26 March 2018 (08:37:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201802.0113.v1

Microbes a Tool for the Remediation of Organotin Pollution Determined by Static Headspace Gas Chromatography-Mass Spectrometry

Christopher Finnegan, David Ryan, Ann-Marie Enright, Guiomar Garcia-Cabellos

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Bioremediation; gas chromatography; green chemistry; mass spectrometry; microcosm; organotin analysis; static headspace; tributyltin (TBT)

Online: 17 February 2018 (11:39:21 CET)

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Preprint REVIEW | doi:10.20944/preprints202101.0606.v1

Sources of ROS Species an Its Harmful and Benefical Effects on Human Health

Sidra Munir

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: ROS; sources of ROS; oxidative stress; ROS and cancer

Online: 29 January 2021 (09:01:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints201908.0145.v1

The First Application of 1H NMR Spectroscopy for the Assessment of the Authenticity of Perfumes

Grzegorz Ciepielowski, Barbara Pacholczyk-Sienicka, Łukasz Albrecht

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: authentication of perfume, flavours, nuclear magnetic resonance, PCA

Online: 12 August 2019 (14:00:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0588.v1

Biophysical, Biochemical and Biomedical Evaluation of Collagen Hydrolysate in Comparison to Sulfated Glucosamine from Marine Organisms and Lipids of Fish Oil Origin Used as Chondroprotective Food Supplements

Thomas Eckert, Mahena Jährling-Butkus, Helen Louton, Monika Burg-Roderfeld, Ning Zhang, Ruiyan Zhang, Karsten Hesse, Athanasios K. Petridis, Tibor Kožár, Jürgen Steinmeyer, Roland Schauer, Peter Engelhard, Anna Kozarova, John W. Hudson, Hans-Christian Siebert

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: osteoarthritis; collagen-hydrolysate; sulfated N-acetyl glucosamine; sialic acids; eicosapentaenoic acid (EPA); MMP-3; ADAMTS-5

Online: 25 May 2021 (08:27:16 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0343.v2

Aptamer-based Biosensors for Antibiotic Detection: A Review

Asol Mehlhorn, Parvaneh Rahimi, Yvonne Joseph

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: biosensor; aptasensor; aptamer; antibiotic; ampicillin; penicillin; gentamicin; kanamycin; neomycin; tobramycin; streptomycin; daunomycin; chloramphenicol; ciprofloxacin; danofloxacin; enrofloxacin; ofloxacin; lincomycin; oxytetracycline; tetracycline; sulfadimethoxine

Online: 27 April 2018 (16:11:09 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0213.v1

Evaluation of the Analytical Conditions for the Determination of Chlorogenic Acid in Coffee Silverskin

Elisa A. Beltrán-Medina, Guadalupe M. Guatemala-Morales, Rosa I. Corona-González, Eduardo Padilla-Camberos, Pedro M. Mondragón-Cortez, Priscilla Ruiz-Palomino, Enrique Arriola-Guevara

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: chlorogenic acid; extraction; coffee silverskin; analytical method

Online: 18 September 2019 (17:21:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201809.0555.v1

Reusability of SPE and Sb-Mmodified SPE Sensors for Trace Pb(II) Determination

Matjaž Finšgar, David Majer, Uroš Maver, Tina Maver

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: screen-printed electrode; Sb-film electrode; SPE; SbFE; stripping analysis; EIS

Online: 28 September 2018 (06:18:11 CEST)

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Preprint REVIEW | doi:10.20944/preprints202101.0181.v2

Lignins Isolated via Catalyst-free Organosolv Pulping from Miscanthus x giganteus, M. sinensis, M. robustus and M. nagara: A Comparative Study

Michel Bergs, Yulia Monakhova, Bernd Diehl, Christopher Konow, Goerg Völkering, Ralf Pude, Margit Schulze

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Miscanthus x giganteus; Miscanthus sinensis; Miscanthus robustus; Miscanthus nagara; lignin; monolignol ratio; low-input crops

Online: 25 January 2021 (14:51:06 CET)

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Abstract: As a low-input crop, Miscanthus offers numerous advantages that, in addition to agricultural applications, permits its exploitation for energy, fuel, and material production. Depending on the Miscanthus genotype, season, and harvest time as well as plant component (leaf versus stem), correlations between structure and properties of the corresponding isolated lignins differ. Here, a comparative study is presented between lignins isolated from M. x giganteus, M. sinensis, M. robustus and M. nagara using a catalyst-free organosolv pulping process. The lignins from different plant constituents are also compared regarding their similarities and differences regarding monolignol ratio and important linkages. Results showed that the plant genotype has the weakest influence on monolignol content and interunit linkages. In contrast, structural differences are more significant among lignins of different harvest time and/or season. Analyses were performed using fast and simple methods such as nuclear magnetic resonance (NMR) spectroscopy. Data was assigned to four different linkages (A: b-O-4 linkage, B: phenylcoumaran, C: resinol, D: b-unsaturated ester). In conclusion, A content is particularly high in leaf-derived lignins at just under 70 % and significantly lower in stem and mixture lignins at around 60 % and almost 65 %. The second most common linkage pattern is D in all isolated lignins, the proportion of which is also strongly dependent on the crop portion. Both stem and mixture lignins, have a relatively high share of approximately 20 % or more (maximum is M. sinensis Sin2 with over 30 %). In the leaf-derived lignins, the proportions are significantly lower on average. Stem samples should be chosen if the highest possible lignin content is desired, specifically from the M. x giganteus genotype, which revealed lignin contents up to 27 %. Due to the better frost resistance and higher stem stability, M. nagara offers some advantages compared to M. x giganteus. Miscanthus crops are shown to be very attractive lignocellulose feedstock (LCF) for second generation biorefineries and lignin generation in Europe.

Preprint ARTICLE | doi:10.20944/preprints202104.0189.v1

Development of Flaxseed Gum/Konjac Glucomannan with Agar as Gelling Agents with Enhanced Elastic Properties

Ji Soo Yang, Junghoon Kim, Jungwoo Hahn, Young Jin Choi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: flaxseed gum; konjac glucomannan; agar; gelling agent

Online: 7 April 2021 (11:10:42 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0623.v1

Towards Clean and Safe Water: A Review on the Emerging Role of Imprinted Polymer-Based Electrochemical Sensors

Xiaofeng Zheng, Sohayb Khaoulani, Nadia Ktari, Momath Lo, Ahmed M. Khalil, Najla FOURATI ENNOURI, Chouki Zerrouki, Mohamed M. Chehimi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: imprinted polymers; electrochemical sensors; pesticides; metal ions; bacteria

Online: 23 April 2021 (09:51:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201805.0475.v1

A Quantitative Structure-activity Relationships Model Based on Hybrid Artificial Intelligence Methods and its Application

Mengshan Li, Huaijin Zhang, Liang Liu, Bingsheng Chen, Lixin Guan, Yan Wu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: quantitative structure-activity relationship; hybrid intelligence; artificial neural network; particle swarm optimization

Online: 31 May 2018 (11:42:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201804.0029.v1

Comparison of the Plasma Temperature and Electron Number Density of Pulsed Electrolyte Cathode Atmospheric Pressure Discharge and Direct Current Solution Cathode Glow Discharge

Jinmei Wang, Shiyu Li, Peichao Zheng, Yanying Chen

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: pulsed electrolyte cathode atmospheric pressure discharge (pulsed-ECAD); plasma temperatures; temperature characteristics; electron number density

Online: 3 April 2018 (03:58:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201803.0198.v1

Rhodamine Derivative Functionalized Magnetic Nano-Platform for Cu²⁺ Sensing and Removal

Jiaxin Wang, Shuhan Wang, Wanqing Tian, Dong Yao, Lining Sun, Liyi Shi, Jinliang Liu

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: copper detection; magnetic nanoparticle; rhodamine B derivative; removal

Online: 23 March 2018 (10:28:53 CET)

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Preprint COMMUNICATION | doi:10.20944/preprints201810.0136.v2

Fluorescence and Naked-Eye Detection of Pb²⁺in Drinking Water Using a Low-Cost Ionophore Based Sensing Scheme

Aron Hakonen, Niklas Strömberg

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: lead ions; fluorescence detection; ionophore; Benzo-18-Crown-6-ether; drinking water

Online: 30 October 2018 (07:42:15 CET)

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Preprint ARTICLE | doi:10.20944/preprints202105.0773.v1

Fermentation Dynamics of Ethiopian Traditional Beer (Tella) As Influenced by Substitution of Gesho (Rhamnus prinoides) With Moringa Stenopetala as Innovation for Nutrition

Ajanw Maru Birhanu, Tadesse Fikre Teferra, Tesfu Bekele lema

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Ethnic beer; borde; shamita; keribo; korefe; indigenous drinks; fermented beverages; probiotics; Farsoo; moringa

Online: 31 May 2021 (12:50:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201901.0290.v1

Biogenic Amines in Traditional Fiore Sardo PDO Sheep Cheese: Assessment, Validation and Application of a RP-HPLC-DAD-UV Method

Claudia Zazzu , Margherita Addis, Marco Caredda, Maria Francesca Scintu, Giovanni Piredda , Gavino Sanna

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Fiore Sardo PDO; biogenic amines; sheep’s cheese; RP-HPLC

Online: 29 January 2019 (09:32:26 CET)

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Preprint REVIEW | doi:10.20944/preprints202005.0060.v3

Fighting the SARS CoV-2 (COVID-19) Pandemic with Soap

Narendra Kumar Chaudhary, Nabina Chaudhary, Manis Dahal, Biswash Guragain, Sumie Rai, Rahul Chaudhary, K.M. Sachin, Reena Lamichhane-Khadka, Ajaya Bhattarai

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: COVID-19; SARS-Cov-2; soap; hand washing; WHO

Online: 6 July 2021 (11:30:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0245.v1

A Comprehensive Biological and Physico-Chemical Characterization of Humic and Fulvic Acids Nanoparticles as a Perspective Drug

Elena V. Valer'evna Uspenskaya, Tatiana Vadimovna Pleteneva, Tatiana Vladimirovna Grebennikova, Ilaha Vagifovna Kazimova, Irina Timofeevna Fedyakina, Varvara Victorovna Lebedeva, Oleg Evgen'evich Latyshev, Olesia Vasil'evna Eliseeva, Viktor Filippovich Larichev, Timur Mansurovich Garaev, Tatiana Vladimirovna Maximova, Mariya Andreevna Morozova, Pham My Hang, Anton Vladimirovich Syroeshkin

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: extract of humic substances; fulvic acid; standardization; nanoparticles of polyelectrolytes; antiviral activity; SARS-CoV-2; VERO-E6; Spirotox-method

Online: 9 June 2021 (07:42:16 CEST)

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This work presents the results of a comprehensive physico-chemical and biological study of hu-mic substances samples – an extract of humic and fulvic acids. The performed loss on drying test showed a 22 times different dry matter content between EHS and FA. The morphology and dis-tribution of particles in the dry residue of the samples assessed using the methods of optical and digital microscopy demonstrated differences in the qualitative features of the microstructures of their surfaces and granulometries. Shimadzu X-ray fluorescence spectrometry revealed Si (8.1 and 1.7%), P (33.5 and 2.7%), S (4.3 and 59.5%), K (1.35 and 2.5%), Ca (10.9 and 3.2%), Mn (0.27 and 0.06%), Fe (11 and 0.05%), Cu (0.16 and 0.45%), Zn (0.06 and 0.02%) in the dry residues of the EHS and FA samples, respectively. A high intensity of the X-ray fluorescence signal for Fe atoms in the EHS sample was demonstrated. The FT-IR spectra for EHS and FA are characterized by simi-lar vibration frequencies that are characteristic of the chromone derivatives (1-benzopyran-4-one). The UV absorption spectrum is characterized by max = 281 nm for FA. The EHS solution showed a fluorescence maximum at em = 560 nm at ex = 280 nm. Using the DLS method, nanoparticles of 1 nm and 200 nm were detected in EHS and FA diluted solutions, which are likely to condition the biochemical and physical properties of humic acids. Using the Spiro-tox-test method, the absence of the toxic effect of humic acids on the cell model of ciliates Sp. am-bigua was established. When the cell model was incubated in a solution of a toxicant of the fluo-roquinolone group, a decrease in toxicity was demonstrated when diluted with the EHS solu-tion. The results of the study of the antiviral activity of EHS and FA showed that the study ob-jects in the culture of Vero-E6 cells, in doses non-toxic to cells, suppress the reproduction of the SARS-CoV-2 virus both in the study of the virucidal effect and in the study of the antiviral activ-ity according to the therapeutic and prophylactic model scheme of injection. The results obtained suggest that standardized drugs based on humic acids may open up new perspectives in their biomedical application as antiviral drugs.

Preprint ARTICLE | doi:10.20944/preprints201712.0082.v1

Chromatographic and Spectroscopic Identification and Recognition of Natural Dyes, Uncommon Dyestuff Components and Mordants Found in the 16th Century Carpet

Olga Otłowska, Marek Ślebioda, Agata Kot-Wasik, Jakub Karczewski, Magdalena Śliwka-Kaszyńska

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: natural dyes; flavonoids; flavone glycosides; anthraquinones; extraction procedure; liquid chromatography mass spectrometry

Online: 13 December 2017 (17:58:00 CET)

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Preprint ARTICLE | doi:10.20944/preprints201810.0406.v1

The application of ATR-FTIR Spectroscopy and the Reversible DNA Conformation as a Sensor to Test the Effectiveness of Platinum(II) Anticancer Drugs

Khansa Al-Jorani, Anja Rüther, Miguela Martin, Rukshani Haputhanthri, Glen B. Deacon, Hsiu Lin Li, Bayden R. Wood

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: platinum; DNA; IR

Online: 18 October 2018 (07:54:20 CEST)

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Platinum(II) complexes have been found to be effective against cancer cells. Cisplatin curbs cell replication by interacting with the deoxyribonucleic acid (DNA), eventually leading to cell death and reducing cell proliferation. In order to investigate the ability of platinum complexes to affect cancer cells, two examplesfrom the class of polyflurophenylorganoamidoplatinum(II) complexes were synthesised and tested on isolated DNA. The two compounds trans-[N,N’-bis(1,2,3,5,6-pentafluorophenyl)ethane-1,2-diaminato(1-)](2,3,4,5,6-pentafluorobenzoato)(pyridine)platinum(II) (PFB), and trans-[N,N’-bis(1,2,3,5,6-pentafluorophenyl)ethane-1,2-diaminato(1-)](2,4,6-trimethylbenzoato)(pyridine)platinum(II) (TMB) were compared with cisplatin through their reaction with DNA. Attenuated Total Reflection Fourier Transform Infrared (ATR-FTIR) spectroscopy was applied to analyse the interaction of the Pt^(II) complexes with DNA in the hydrated, dehydrated and rehydrated state. These were compared with control DNA in acetone/water (PFB, TMB) and isotonic saline (cisplatin) under the same conditions. Principle Component Analysis (PCA) was applied to compare the ATR-FTIR spectra of the untreated control DNA with spectra of PFB and TMB treated DNA samples. Disruptions in the conformation of DNA treated with the Pt^(II) complexes upon rehydration were mainly observed by monitoring the position of the IR-bandaround 1711 cm^-1assigned to the DNA base-stacking vibration. Furthermore, other intensity changes in the phosphodiester bands of DNA at ~1234 cm^-1 and 1225 cm^-1 and shifts in the dianionic phosphodiester vibration at 966 cm^-1 were observed. The isolated double stranded DNA (dsDNA) or single stranded DNA (ssDNA) showed different structural changes when incubated with the studied compounds. PCA confirmed PFB had the most dramatic effect by denaturing both dsDNA and ssDNA. Both compounds, along with cisplatin, induced changes in DNA bands at 1711, 1088, 1051 and 966 cm^-1 indicative of DNA conformation changes. The ability to monitor conformational change with infrared spectroscopy paves the way for a sensor to screen for new anticancer therapeutic agents.

Preprint ARTICLE | doi:10.20944/preprints201907.0235.v1

Coupling MicroNIR/Chemometrics for the On-Site Detection of Cannabinoids in Hemp Flours

Roberta Risoluti, Giuseppina Gullifa, Alfredo Battistini, Stefano Materazzi

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: cannabinoids; hemp flour; MicroNIR; chemometrics

Online: 22 July 2019 (08:13:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201907.0263.v1

Open LabBot and RmsiGUI: Community Development Kit for Sampling Automation and Ambient Imaging

Ignacio Rosas-Román, Cesaré Ovando-Vázquez, Abigail Moreno-Pedraza, Héctor Guillén-Alonso, Robert Winkler

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: ambient ionization; mass spectrometry; high-throughput sampling; imaging; modular robot; open hardware; lab automation; peer production; open software; low-temperature plasma

Online: 23 July 2019 (15:20:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202107.0278.v1

Characterization and Investigation of Stigmasterol Isolated from Rodent Tuber Mutant Plant (Typhonium flagelliforme), Its Molecular Docking as Anticancer on MF-7 Cells

Nesti Fronika Sianipar, Yuni Elsa Hadisaputri, Khoirunnisa Assidqi, Supriatno Salam, Muhammad Yusuf, Wanda Destiarani, Ragapadmi Purnamaningsih, Idris Gautama So

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Typhonium flagelliforme; MCF-7 cell line; stigmasterol; agonistic; mutant plant

Online: 13 July 2021 (08:27:04 CEST)

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Working Paper ARTICLE

Proton Detected Solid-State NMR of Membrane Proteins at 28 Tesla and 100 Khz Magic-Angle Spinning

Evgeny Nimerovsky, Kumar Tekwani Movellan, Xizhou Zhang, Marcel C. Forster, Eszter Najbauer, Kai Xue, Rıza Dervişoğlu, Karin Giller, Christian Griesinger, Stefan Becker, Loren B Andreas

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: magic-angle spinning; solid-state NMR; membrane protein; beta barrel; transmembrane; proton detection; high magnetic field

Online: 29 March 2021 (12:49:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202104.0258.v1

Towards Scaling-up Photocatalytic Process for Multiphase Environmental Applications: A Review

Mohamed Gar Alalm, Ridha Djellabi, Daniela Meroni, Carlo Pirola, Claudia L. Bianchi, Daria Camilla Boffito

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Air pollution; Photocatalysis; Reactors; Wastewater; Water matrix; Scaling up

Online: 9 April 2021 (13:04:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202011.0027.v1

PNA-based Graphene Oxide/porous Silicon Hybrid Biosensor: Towards a Label-free Optical Assay for Brugada Syndrome

Rosalba Moretta, Monica Terracciano, Nicola Borbone, Giorgia Oliviero, Chiara Schiattarella, Gennaro Piccialli, Andrea Patrizia Falanga, Maria Marzano, Principia Dardano, Luca De Stefano, Ilaria Rea

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Brugada syndrome; peptide nucleic acid-PNA, porous silicon; graphene oxide; optical biosensor; hybrid device

Online: 2 November 2020 (11:12:24 CET)

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Preprint ARTICLE | doi:10.20944/preprints202005.0071.v1

COVID-19: Simultaneous Surveillance Studies and Case Series, Jordan as a Case Study

Ahmad Alkhawaldeh

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: COVID-19; coronavirus; SARS-CoV-2; Simultaneous surveillance; Jordan

Online: 5 May 2020 (10:57:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0401.v1

Polycyclic Aromatic Hydrocarbons in Soil Samples from Diboll, East Texas (USA)

Kefa Karimu Onchoke, Jorge J. Ojeda, Michael A. Janusa

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: soil; PAHs; diboll; fluoranthene; pyrene; gas chromatography-mass spectrometry

Online: 23 August 2018 (04:18:17 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0451.v1

Fatty Acid Composition, Enrichment of Polyunsaturated Fatty Acids and Bioactivities of Oils from Four Species of Animals Bone Marrow

Parhat Rozi, Aytursun Abuduwaili, Mourboul Abilise, Gao Yan-Hua, Parida Maimaiti, Abulimiti Yili

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: bone marrow oil; unsaturated fatty acid; urea inclusion; low temperature crystallization; GC/MS

Online: 27 August 2018 (11:02:38 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201708.0031.v1

Detection of Aβ(1-40) Protein in Human Serum as A Causative Agent of Alzheimer’s Disease by Strain Gauge Cantilever Biosensor Immobilizing Liposome Incorporating Cholesterol

Tomoya Taniguchi, Yuki Murakami , Masayuki Sohgawa , Kaoru Yamashita, Minoru Noda

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: cantilever; NiCr strain gauge; biosensor; liposome; amyloid beta; aggregation; fibrillization; interaction; human serum; digital low-pass filtering procedure

Online: 8 August 2017 (09:57:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201807.0313.v1

Identification of volatile compounds and selection of discriminant markers for elephant dung coffee using static headspace gas chromatography–mass spectrometry and chemometrics

Poowadol Thammarat, Chadin Kulsing, Kanet Wongravee, Natchanun Leepipatpiboon, Thumnoon Nhujak

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: elephant dung coffee; volatile compound; discriminant marker; SHS GC–MS; chemometrics; coffee authentication

Online: 17 July 2018 (15:02:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201909.0281.v1

Releases of Fire-Derived Contaminants from Water Pipes Made of Polyvinyl Chloride Polymer

Ngee-Sing Chong, Saidi Abdulramoni, Dwight Patterson, Heather Brown

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: polymer-derived contaminants; pvc fires; fire emissions analysis; polymer leachate characterization; gc-ms and ftir analysis of gaseous pollutants

Online: 25 September 2019 (09:12:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints201808.0436.v1

Synthesis of Carbon dots-based Fluorescent Probe for the High Selective Detection of Mercury Ions

Li Song, Yanyan Cui

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Fluorescent carbon dots, hydrothermal treatment, characterization, cell imaging, mercury ions, selective and sensitive detection

Online: 24 August 2018 (12:29:30 CEST)

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Preprint REVIEW | doi:10.20944/preprints201804.0343.v1

Aptamer-based Biosensors for Antibiotic Detection: A Review

Asol Mehlhorn, Parvaneh Rahimi, Yvonne Joseph

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: biosensor; aptasensor; aptamer; antibiotic; ampicillin; penicillin; gentamicin; kanamycin; neomycin; tobramycin; streptomycin; daunomycin; chloramphenicol; ciprofloxacin; danofloxacin; enrofloxacin; ofloxacin; lincomycin; oxytetracycline; tetracycline; sulfadimethoxine

Online: 26 April 2018 (16:51:27 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0493.v1

Pumice as a Novel Nature Heterogeneous Catalyst for Synthesis of 3,4-dihydropyrimidine-2-(1H)-Ones/Thiones via Biginelli Reaction under Solvent-free Conditions

Lamya H. Al-Wahaibi, Antar A. Abdelhamid, Sayed A. Saber, Nadia A.A. Elkanzi, Ali M. Ali

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: One pot reaction; 3,4- Dihydropyrimidin-2(1H) ones / thiones and Pumice

Online: 20 May 2021 (13:38:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202106.0576.v1

Neuroprotective Efficacy of Folecitin From Hypericum Oblongifolium Against LPS-Induced Oxidative Stress, Neurodegeneration, and Memory Dysfunction

Umar Farooq, Shahid Ali Shah, Taous Khan, Rahim Ullah, Naila Raziq, Muhammad Shahid, Ameer Khusro, Muhammad Umar Khayam Sahibzada, Veronique Seidel, Adel Alkhedaide, Gaber El-Saber Batiha, Niranjan Koirala

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: Hypericum oblongifolium; Alzheimer’s disease; Folecitin; Memory impairment; Neurodegenerative disease; Neuroprotection

Online: 23 June 2021 (11:25:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202105.0250.v1

Acid Dissolution of Neodymium Magnet Nd-Fe-B in Different Conditions

Akmaral Gazizovna Ismailova, Gulsara Zhakashovna Akanova, Duisek Khaissagalievich Kamysbayev

Subject: Chemistry And Materials Science, Analytical Chemistry Keywords: acid dissolution; neodymium magnet; open system; microwave sample preparation system; ICP-MS analysis

Online: 11 May 2021 (15:06:50 CEST)

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Chemistry and Materials Science