Wed, 17 October 2018
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Preprint ARTICLE Download: 22| View: 29| Comments: 0| doi:10.20944/preprints201810.0381.v1
Subject: Chemistry, Medicinal Chemistry; Biginelli reaction; dihydropyrimidin-2-thiones; synthesis, virtual screening, drug design; LaSOM 282
Online: 17 October 2018 (11:34:06 CEST)
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Preprint ARTICLE Download: 30| View: 43| Comments: 0| doi:10.20944/preprints201810.0375.v1
Subject: Chemistry, Medicinal Chemistry; endophytic fungi; sesterterpene; cytotoxic activity; pancreatic cancer
Online: 17 October 2018 (08:39:51 CEST)
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Tue, 16 October 2018
Preprint REVIEW Download: 30| View: 44| Comments: 0| doi:10.20944/preprints201810.0360.v1
Subject: Chemistry, Medicinal Chemistry; Molecular Dynamics, CoSolvent Molecular Dynamics, Drug design, Fragment Screening, Docking
Online: 16 October 2018 (14:15:17 CEST)
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Preprint ARTICLE Download: 23| View: 35| Comments: 0| doi:10.20944/preprints201810.0355.v1
Subject: Chemistry, Medicinal Chemistry; assay; diarrhea; isolate; hydrolysis; proteins; inhibition zone
Online: 16 October 2018 (13:26:59 CEST)
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Fri, 28 September 2018
Preprint ARTICLE Download: 59| View: 57| Comments: 0| doi:10.20944/preprints201809.0564.v1
Subject: Chemistry, Medicinal Chemistry; Pritimerin; target fishing; druggability; network pharmacology
Online: 28 September 2018 (13:54:58 CEST)
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Mon, 24 September 2018
Preprint ARTICLE Download: 40| View: 62| Comments: 0| doi:10.20944/preprints201809.0451.v1
Subject: Chemistry, Medicinal Chemistry; Free Radical, Phenol, Scropholaria Striata Boiss, DPPH, Folin-Ciocalteu, Height, Soil
Online: 24 September 2018 (12:27:02 CEST)
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Mon, 3 September 2018
Preprint ARTICLE Download: 110| View: 169| Comments: 0| doi:10.20944/preprints201809.0048.v1
Subject: Chemistry, Medicinal Chemistry; pretargeting; Fusarinine C; rituximab; click chemistry; multimerization; PET; gallium-68
Online: 3 September 2018 (17:55:44 CEST)
Thu, 30 August 2018
Preprint ARTICLE Download: 91| View: 119| Comments: 0| doi:10.20944/preprints201808.0516.v1
Subject: Chemistry, Medicinal Chemistry; ALK5 inhibitor; TGF-β; kinase assay; selectivity; docking
Online: 30 August 2018 (07:52:08 CEST)
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Wed, 29 August 2018
Preprint REVIEW Download: 123| View: 109| Comments: 0| doi:10.20944/preprints201808.0488.v1
Subject: Chemistry, Medicinal Chemistry; Sarcophyton; Sinularia; Lobophytum; new compounds; anti-microbial; anti-inflammatory; anti-tumoral
Online: 29 August 2018 (11:03:48 CEST)
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Mon, 27 August 2018
Preprint ARTICLE Download: 107| View: 146| Comments: 0| doi:10.20944/preprints201808.0463.v1
Subject: Chemistry, Medicinal Chemistry; Factor Xa ( F-Xa), Cardiovascular diseases (CD), Coronary heart disease (CHD), Tissue plasminogen activator (t-PA), Urokinase (UK), Streptokinase (SK), N,N-Dimethyl formamide (DMF)
Online: 27 August 2018 (16:54:10 CEST)
Thu, 2 August 2018
Preprint REVIEW Download: 193| View: 115| Comments: 0| doi:10.20944/preprints201808.0032.v1
Subject: Chemistry, Medicinal Chemistry; caffeine; methylxanthine; chlorogenic acid; caffeic acid; inflammation; antimutagen; anticancer; antioxidant
Online: 2 August 2018 (07:14:02 CEST)
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Wed, 1 August 2018
Preprint ARTICLE Download: 73| View: 125| Comments: 1| doi:10.20944/preprints201808.0011.v1
Subject: Chemistry, Medicinal Chemistry; chitosan; aldehydes; chalcone; MIC; anti-cancer activity
Online: 1 August 2018 (11:38:35 CEST)
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Sun, 29 July 2018
Preprint ARTICLE Download: 88| View: 145| Comments: 0| doi:10.20944/preprints201807.0552.v1
Subject: Chemistry, Medicinal Chemistry; Hedgehog signaling; Veratrum californicum; cyclopamine; HPLC-MS; Shh-Light II cells
Online: 29 July 2018 (01:25:31 CEST)
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Mon, 23 July 2018
Preprint ARTICLE Download: 141| View: 178| Comments: 0| doi:10.20944/preprints201807.0427.v1
Subject: Chemistry, Medicinal Chemistry; Pharmacophore; 3D-QSAR; virtual screening; D3R selective antagonist; molecular docking; CNS-like
Online: 23 July 2018 (16:09:10 CEST)
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Mon, 16 July 2018
Preprint ARTICLE Download: 116| View: 130| Comments: 0| doi:10.20944/preprints201807.0264.v1
Subject: Chemistry, Medicinal Chemistry; Orotic hydrazide, Arylhydrazone, Mesenchymal Stem Cells, Proliferation
Online: 16 July 2018 (11:06:33 CEST)
Sat, 14 July 2018
Preprint ARTICLE Download: 138| View: 271| Comments: 0| doi:10.20944/preprints201807.0251.v1
Subject: Chemistry, Medicinal Chemistry; docking; epigenetics; epi-informatics; molecular interactions; molecular dynamics; natural products; flavonoids
Online: 14 July 2018 (19:45:16 CEST)
Fri, 13 July 2018
Preprint REVIEW Download: 193| View: 181| Comments: 0| doi:10.20944/preprints201807.0226.v1
Subject: Chemistry, Medicinal Chemistry; galvanic replacement; photothermal therapy; drug delivery; nanoparticles; cancer treatment
Online: 13 July 2018 (07:11:21 CEST)
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Fri, 6 July 2018
Preprint REVIEW Download: 174| View: 258| Comments: 0| doi:10.20944/preprints201807.0116.v1
Subject: Chemistry, Medicinal Chemistry; chemical space; chemoinformatics; data mining; databases; DNMT inhibitors; drug discovery; epi-informatics; molecular modeling; similarity searching; virtual screening
Online: 6 July 2018 (12:04:44 CEST)
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Preprint ARTICLE Download: 123| View: 212| Comments: 0| doi:10.20944/preprints201807.0110.v1
Subject: Chemistry, Medicinal Chemistry; G-quadruplex; oxadiazole/pyridine polyheteroaryls; G4-ligands; FRET-melting; G4-FID; circular dichroism
Online: 6 July 2018 (10:28:22 CEST)
Tue, 3 July 2018
Preprint ARTICLE Download: 120| View: 163| Comments: 0| doi:10.20944/preprints201807.0039.v1
Subject: Chemistry, Medicinal Chemistry; xanthohumol; biotinylated chalcones; anticancer activity; antioxidants
Online: 3 July 2018 (13:42:41 CEST)
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Mon, 4 June 2018
Preprint ARTICLE Download: 139| View: 159| Comments: 0| doi:10.20944/preprints201711.0091.v2
Subject: Chemistry, Medicinal Chemistry; asymmetrical mono-carbonyl analogs of curcumin (AMACs); synthesis; cytotoxicity, Vero; HeLa; MCF7; cell lines
Online: 4 June 2018 (10:19:03 CEST)
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Wed, 30 May 2018
Preprint ARTICLE Download: 145| View: 173| Comments: 0| doi:10.20944/preprints201805.0437.v1
Subject: Chemistry, Medicinal Chemistry; Jatropha pelargoniifolia; alkaloids; flavonoids; coumarinolignans; diterpenes; anti-inflammatory; antinociceptive; antipyretic; free radical scavenging
Online: 30 May 2018 (08:15:42 CEST)
Tue, 29 May 2018
Preprint ARTICLE Download: 148| View: 209| Comments: 0| doi:10.20944/preprints201805.0419.v1
Subject: Chemistry, Medicinal Chemistry; doxorubicin; heterobifunctional; linker
Online: 29 May 2018 (10:54:56 CEST)
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Mon, 14 May 2018
Preprint ARTICLE Download: 194| View: 229| Comments: 0| doi:10.20944/preprints201805.0189.v1
Subject: Chemistry, Medicinal Chemistry; G-quadruplex DNA; interactions; berberine and palmatine analogues; chemotherapy; NMR; FRET and MST assays
Online: 14 May 2018 (13:44:10 CEST)
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Tue, 8 May 2018
Preprint ARTICLE Download: 154| View: 238| Comments: 0| doi:10.20944/preprints201805.0133.v1
Subject: Chemistry, Medicinal Chemistry; antioxidant potential; molecular docking; molecular descriptors; binding free energy; free radicals; oxidative stress
Online: 8 May 2018 (17:38:38 CEST)
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Fri, 4 May 2018
Preprint ARTICLE Download: 162| View: 245| Comments: 0| doi:10.20944/preprints201805.0085.v1
Subject: Chemistry, Medicinal Chemistry; 7-acetamido-2-aryl-5-bromoindoles; trifluoroacetylation; cytotoxicity; apoptosis; tubulin polymerization; molecular docking
Online: 4 May 2018 (09:47:06 CEST)
Mon, 23 April 2018
Preprint ARTICLE Download: 182| View: 191| Comments: 0| doi:10.20944/preprints201804.0282.v1
Subject: Chemistry, Medicinal Chemistry; aminosteroid; aminocycloartane; alkaloid; 3D-QSAR; CoMFA; antitrypanosomal activity; cytotoxicity
Online: 23 April 2018 (13:02:16 CEST)
Thu, 5 April 2018
Preprint REVIEW Download: 187| View: 216| Comments: 0| doi:10.20944/preprints201804.0071.v1
Subject: Chemistry, Medicinal Chemistry; Sulfenic acids; Sulfoxides; Sulfones; Disulfides; Alliin derivatives; Glycoconjugates; Pyrimidine derivatives.
Online: 5 April 2018 (18:30:18 CEST)
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Mon, 19 March 2018
Preprint ARTICLE Download: 202| View: 424| Comments: 0| doi:10.20944/preprints201803.0142.v1
Subject: Chemistry, Medicinal Chemistry; chitosan; thermoresponsive hydrogel; nitric oxide; s-nitrosothiols; biocompatibility; antimicrobial; Pseudomonas aeruginosa; pluronic F127
Online: 19 March 2018 (08:25:27 CET)
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Wed, 7 March 2018
Preprint ARTICLE Download: 233| View: 485| Comments: 2| doi:10.20944/preprints201803.0050.v1
Subject: Chemistry, Medicinal Chemistry; carboxamide; carbohydrazine; antibacterial; antifungal; molecular docking; Schiff base; NMR; IR
Online: 7 March 2018 (06:11:10 CET)
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Thu, 1 March 2018
Preprint ARTICLE Download: 312| View: 283| Comments: 0| doi:10.20944/preprints201803.0003.v1
Subject: Chemistry, Medicinal Chemistry; derivatives of N-phenylanthranilic acids; anti-inflammatory activity; flexible molecular docking; microsomal prostaglandin E synthase-1
Online: 1 March 2018 (05:58:58 CET)
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Thu, 22 February 2018
Preprint ARTICLE Download: 332| View: 422| Comments: 0| doi:10.20944/preprints201802.0142.v1
Subject: Chemistry, Medicinal Chemistry; reactive selenium species; arylmethyl selenocyanate; cellular thiolstat; antimicrobial; anticancer; ESKAPE; multidrug resistance
Online: 22 February 2018 (12:34:22 CET)
Fri, 2 February 2018
Preprint ARTICLE Download: 227| View: 325| Comments: 0| doi:10.20944/preprints201802.0021.v1
Subject: Chemistry, Medicinal Chemistry; Keywords: one-pot synthesis; single crystal x-ray crystallography; oxovanadium(IV); zinc(II); spectroscopic studies; in vitro antibacterial studies.
Online: 2 February 2018 (17:00:10 CET)
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Wed, 31 January 2018
Preprint ARTICLE Download: 486| View: 366| Comments: 0| doi:10.20944/preprints201801.0292.v1
Subject: Chemistry, Medicinal Chemistry; African medicinal plants; Leishmaniasis; natural products; protozoal diseases; Schistosomiasis; Trypanosomiasis
Online: 31 January 2018 (06:28:15 CET)
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Wed, 10 January 2018
Preprint SHORT NOTE Download: 266| View: 340| Comments: 0| doi:10.20944/preprints201801.0087.v1
Subject: Chemistry, Medicinal Chemistry; redox-sensitive; disulfide linker; gemini amphiphiles; gene therapy
Online: 10 January 2018 (10:12:03 CET)
Tue, 9 January 2018
Preprint ARTICLE Download: 365| View: 405| Comments: 0| doi:10.20944/preprints201801.0079.v1
Subject: Chemistry, Medicinal Chemistry; Diabetes; GPR40; AKRB1; PPARγ; GLUT-4
Online: 9 January 2018 (09:54:18 CET)
Tue, 2 January 2018
Preprint ARTICLE Download: 314| View: 347| Comments: 0| doi:10.20944/preprints201711.0177.v2
Subject: Chemistry, Medicinal Chemistry; Leishmania; thiochroman-4-ones; acyl hydrazone; cytotoxicity
Online: 2 January 2018 (11:11:55 CET)
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Mon, 11 December 2017
Preprint ARTICLE Download: 274| View: 458| Comments: 0| doi:10.20944/preprints201712.0066.v1
Subject: Chemistry, Medicinal Chemistry; cancer; cell line; urea derivatives; synthesis; antiproliferative activity
Online: 11 December 2017 (16:10:36 CET)
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Tue, 31 October 2017
Preprint ARTICLE Download: 452| View: 348| Comments: 0| doi:10.20944/preprints201710.0200.v1
Subject: Chemistry, Medicinal Chemistry; 4-Thiazolidinones; ORAC assay; Metalloproteinase-9; Docking study; Keratinocytes cultures; Nuclear factor -kB.
Online: 31 October 2017 (17:36:16 CET)
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Preprint ARTICLE Download: 402| View: 485| Comments: 0| doi:10.20944/preprints201710.0196.v1
Subject: Chemistry, Medicinal Chemistry; osteoporosis; herbal medicine; Kukoamine B; osteoblast; osteoclast; bone mineral density; ovariectomized mice
Online: 31 October 2017 (16:35:04 CET)
Preprint ARTICLE Download: 1039| View: 578| Comments: 0| doi:10.20944/preprints201710.0194.v1
Subject: Chemistry, Medicinal Chemistry; Africa; Terminalia brownii; antifungal extracts; Aspergillus, Nattrassia, Fusarium; triterpenoids; flavonoids; ellagitannins; stilbenes
Online: 31 October 2017 (10:54:35 CET)
Fri, 13 October 2017
Preprint ARTICLE Download: 352| View: 474| Comments: 0| doi:10.20944/preprints201710.0088.v1
Subject: Chemistry, Medicinal Chemistry; Caesalpinia sappan; cassane diterpenes; N bridge; antimalarial activity
Online: 13 October 2017 (08:30:04 CEST)
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Thu, 17 August 2017
Preprint ARTICLE Download: 1174| View: 1427| Comments: 0| doi:10.20944/preprints201708.0057.v1
Subject: Chemistry, Medicinal Chemistry; [18F]PSMA-1007; fluorine-18; PSMA; automation; prostate cancer; PET
Online: 17 August 2017 (08:10:57 CEST)
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Tue, 11 July 2017
Preprint REVIEW Download: 673| View: 526| Comments: 0| doi:10.20944/preprints201707.0019.v1
Subject: Chemistry, Medicinal Chemistry; affective disorders; alzheimer’s disease; l-Deprenyl (Selegiline); donepezil; galantamine; value; inhibitor constant; mechanism-based inhibition; multitarget-directed ligand (MTDL); rasagiline; rivastigmine
Online: 11 July 2017 (07:58:53 CEST)
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Fri, 30 June 2017
Preprint ARTICLE Download: 598| View: 693| Comments: 0| doi:10.20944/preprints201706.0132.v1
Subject: Chemistry, Medicinal Chemistry; arylamine N-acetyltransferases; cancer; tuberculosis; drug discovery; traditional Chinese medicine; virtual screening; molecular dynamics simulation; MM-PBSA
Online: 30 June 2017 (13:36:22 CEST)
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Preprint ARTICLE Download: 593| View: 616| Comments: 0| doi:10.20944/preprints201706.0128.v1
Subject: Chemistry, Medicinal Chemistry; steroidal dimer; steroidal N-heterocycles; antiproliferative activity; esophageal cancer cells
Online: 30 June 2017 (09:43:06 CEST)
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Fri, 16 June 2017
Preprint COMMUNICATION Download: 578| View: 641| Comments: 0| doi:10.20944/preprints201706.0074.v1
Subject: Chemistry, Medicinal Chemistry; deep-sea; actinomycete; Microbacterium sp.; indole
Online: 16 June 2017 (06:40:54 CEST)
Mon, 15 May 2017
Preprint REVIEW Download: 1575| View: 997| Comments: 0| doi:10.20944/preprints201705.0115.v1
Subject: Chemistry, Medicinal Chemistry; Palladium; Suzuki cross coupling; natural product; non-natural product
Online: 15 May 2017 (20:30:52 CEST)
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Mon, 24 April 2017
Preprint ESSAY Download: 612| View: 723| Comments: 0| doi:10.20944/preprints201704.0120.v2
Subject: Chemistry, Medicinal Chemistry; oleanolic acid derivatives; synthesis; anti-tumor activity; molecular docking; computer-aided drug design
Online: 24 April 2017 (14:08:36 CEST)
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Thu, 16 March 2017
Preprint REVIEW Download: 828| View: 889| Comments: 0| doi:10.20944/preprints201703.0118.v1
Subject: Chemistry, Medicinal Chemistry; dengue; chikungunya; virus enzymes; antiviral; natural products
Online: 16 March 2017 (10:42:52 CET)
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Fri, 10 March 2017
Preprint ARTICLE Download: 811| View: 864| Comments: 0| doi:10.20944/preprints201703.0053.v1
Subject: Chemistry, Medicinal Chemistry; 1,3,4-Thiadiazole; 1,2,4-Triazole; synthesis; MTT assay; Cytotoxicity of Schiff base
Online: 10 March 2017 (11:11:56 CET)
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Tue, 7 March 2017
Preprint ARTICLE Download: 602| View: 738| Comments: 0| doi:10.20944/preprints201703.0037.v1
Subject: Chemistry, Medicinal Chemistry; hypertension; 4-hydroxy-2-nonenal (4HNE); reactive oxygen species(ROS)
Online: 7 March 2017 (08:00:16 CET)
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Thu, 15 December 2016
Preprint ARTICLE Download: 999| View: 916| Comments: 0| doi:10.20944/preprints201612.0082.v1
Subject: Chemistry, Medicinal Chemistry; transdermal physical penetration technology; Fu’s Cupping Therapy; pharmacokinetics; SEM; TEM; stratum corneum; mechanism
Online: 15 December 2016 (11:57:46 CET)
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Sun, 27 November 2016
Preprint CASE REPORT Download: 916| View: 1073| Comments: 1| doi:10.20944/preprints201611.0134.v1
Subject: Chemistry, Medicinal Chemistry; GINKGO; hyperlipideamia; lipid profile
Online: 27 November 2016 (05:43:15 CET)
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Mon, 14 November 2016
Preprint ARTICLE Download: 818| View: 832| Comments: 0| doi:10.20944/preprints201611.0072.v1
Subject: Chemistry, Medicinal Chemistry; aporphine derivatives; antiarrhythmia; 10,11-dibromocrebanine; 3-bromocrebanine; crebanine; stephanine
Online: 14 November 2016 (08:24:04 CET)
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Preprint ARTICLE Download: 1114| View: 1050| Comments: 0| doi:10.20944/preprints201611.0071.v1
Subject: Chemistry, Medicinal Chemistry; diabetes mellitus; metformin; glibenclamide and lipid profile
Online: 14 November 2016 (08:14:00 CET)
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Mon, 7 November 2016
Preprint ARTICLE Download: 660| View: 877| Comments: 0| doi:10.20944/preprints201611.0043.v1
Subject: Chemistry, Medicinal Chemistry; chalcone; cytotoxic activity; pharmacophore model
Online: 7 November 2016 (09:30:12 CET)
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Mon, 31 October 2016
Preprint ARTICLE Download: 908| View: 874| Comments: 1| doi:10.20944/preprints201610.0137.v1
Subject: Chemistry, Medicinal Chemistry; glibenclamide therapies; glycemic; Glucose-6-phosphatase
Online: 31 October 2016 (09:35:41 CET)
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Thu, 29 September 2016
Preprint ARTICLE Download: 1120| View: 1174| Comments: 0| doi:10.20944/preprints201609.0122.v1
Subject: Chemistry, Medicinal Chemistry; Cancer; FGFR; Inhibitor; 4‐Substituted‐1H‐indazole
Online: 29 September 2016 (17:42:08 CEST)
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Mon, 15 August 2016
Preprint ARTICLE Download: 1376| View: 1043| Comments: 0| doi:10.20944/preprints201608.0145.v1
Subject: Chemistry, Medicinal Chemistry; methyl 3,4-dihydroxybenzoate; oxidative stress; apoptosis; neuroprotection; nuclear factor erythroid 2-related factor 2
Online: 15 August 2016 (12:42:05 CEST)
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Thu, 11 August 2016
Preprint ARTICLE Download: 1451| View: 1208| Comments: 0| doi:10.20944/preprints201608.0119.v1
Subject: Chemistry, Medicinal Chemistry; thiazoles; thiadiazoles; hydrazonoyl chlorides; anticancer activity; structure activity relationship
Online: 11 August 2016 (13:05:21 CEST)
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Tue, 9 August 2016
Preprint ARTICLE Download: 1125| View: 1113| Comments: 0| doi:10.20944/preprints201608.0086.v1
Subject: Chemistry, Medicinal Chemistry; Acid hydrolysis; Degradation product; Saikosaponin a
Online: 9 August 2016 (13:32:29 CEST)
Tue, 2 August 2016
Preprint ARTICLE Download: 1392| View: 1251| Comments: 0| doi:10.20944/preprints201608.0013.v1
Subject: Chemistry, Medicinal Chemistry; α-mangostin; antibacterial; antifungal; food packaging; semi-synthetic modification
Online: 2 August 2016 (11:02:09 CEST)
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