Thu, 2 August 2018
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Preprint REVIEW Download: 80| View: 58| Comments: 0| doi:10.20944/preprints201808.0032.v1
Subject: Chemistry, Medicinal Chemistry; caffeine; methylxanthine; chlorogenic acid; caffeic acid; inflammation; antimutagen; anticancer; antioxidant
Online: 2 August 2018 (05:14:02 CEST)
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Wed, 1 August 2018
Preprint ARTICLE Download: 23| View: 54| Comments: 1| doi:10.20944/preprints201808.0011.v1
Subject: Chemistry, Medicinal Chemistry; chitosan; aldehydes; chalcone; MIC; anti-cancer activity
Online: 1 August 2018 (09:38:35 CEST)
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Sat, 28 July 2018
Preprint ARTICLE Download: 40| View: 83| Comments: 0| doi:10.20944/preprints201807.0552.v1
Subject: Chemistry, Medicinal Chemistry; Hedgehog signaling; Veratrum californicum; cyclopamine; HPLC-MS; Shh-Light II cells
Online: 28 July 2018 (23:25:31 CEST)
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Mon, 23 July 2018
Preprint ARTICLE Download: 47| View: 87| Comments: 0| doi:10.20944/preprints201807.0427.v1
Subject: Chemistry, Medicinal Chemistry; Pharmacophore; 3D-QSAR; virtual screening; D3R selective antagonist; molecular docking; CNS-like
Online: 23 July 2018 (14:09:10 CEST)
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Mon, 16 July 2018
Preprint ARTICLE Download: 54| View: 64| Comments: 0| doi:10.20944/preprints201807.0264.v1
Subject: Chemistry, Medicinal Chemistry; Orotic hydrazide, Arylhydrazone, Mesenchymal Stem Cells, Proliferation
Online: 16 July 2018 (09:06:33 CEST)
Sat, 14 July 2018
Preprint ARTICLE Download: 84| View: 174| Comments: 0| doi:10.20944/preprints201807.0251.v1
Subject: Chemistry, Medicinal Chemistry; docking; epigenetics; epi-informatics; molecular interactions; molecular dynamics; natural products; flavonoids
Online: 14 July 2018 (17:45:16 CEST)
Fri, 13 July 2018
Preprint REVIEW Download: 96| View: 118| Comments: 0| doi:10.20944/preprints201807.0226.v1
Subject: Chemistry, Medicinal Chemistry; galvanic replacement; photothermal therapy; drug delivery; nanoparticles; cancer treatment
Online: 13 July 2018 (05:11:21 CEST)
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Fri, 6 July 2018
Preprint REVIEW Download: 78| View: 164| Comments: 0| doi:10.20944/preprints201807.0116.v1
Subject: Chemistry, Medicinal Chemistry; chemical space; chemoinformatics; data mining; databases; DNMT inhibitors; drug discovery; epi-informatics; molecular modeling; similarity searching; virtual screening
Online: 6 July 2018 (10:04:44 CEST)
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Preprint ARTICLE Download: 64| View: 135| Comments: 0| doi:10.20944/preprints201807.0110.v1
Subject: Chemistry, Medicinal Chemistry; G-quadruplex; oxadiazole/pyridine polyheteroaryls; G4-ligands; FRET-melting; G4-FID; circular dichroism
Online: 6 July 2018 (08:28:22 CEST)
Tue, 3 July 2018
Preprint ARTICLE Download: 70| View: 95| Comments: 0| doi:10.20944/preprints201807.0039.v1
Subject: Chemistry, Medicinal Chemistry; xanthohumol; biotinylated chalcones; anticancer activity; antioxidants
Online: 3 July 2018 (11:42:41 CEST)
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Mon, 4 June 2018
Preprint ARTICLE Download: 74| View: 112| Comments: 0| doi:10.20944/preprints201711.0091.v2
Subject: Chemistry, Medicinal Chemistry; asymmetrical mono-carbonyl analogs of curcumin (AMACs); synthesis; cytotoxicity, Vero; HeLa; MCF7; cell lines
Online: 4 June 2018 (08:19:03 CEST)
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Wed, 30 May 2018
Preprint ARTICLE Download: 96| View: 125| Comments: 0| doi:10.20944/preprints201805.0437.v1
Subject: Chemistry, Medicinal Chemistry; Jatropha pelargoniifolia; alkaloids; flavonoids; coumarinolignans; diterpenes; anti-inflammatory; antinociceptive; antipyretic; free radical scavenging
Online: 30 May 2018 (06:15:42 CEST)
Tue, 29 May 2018
Preprint ARTICLE Download: 97| View: 135| Comments: 0| doi:10.20944/preprints201805.0419.v1
Subject: Chemistry, Medicinal Chemistry; doxorubicin; heterobifunctional; linker
Online: 29 May 2018 (08:54:56 CEST)
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Mon, 14 May 2018
Preprint ARTICLE Download: 121| View: 155| Comments: 0| doi:10.20944/preprints201805.0189.v1
Subject: Chemistry, Medicinal Chemistry; G-quadruplex DNA; interactions; berberine and palmatine analogues; chemotherapy; NMR; FRET and MST assays
Online: 14 May 2018 (11:44:10 CEST)
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Tue, 8 May 2018
Preprint ARTICLE Download: 104| View: 184| Comments: 0| doi:10.20944/preprints201805.0133.v1
Subject: Chemistry, Medicinal Chemistry; antioxidant potential; molecular docking; molecular descriptors; binding free energy; free radicals; oxidative stress
Online: 8 May 2018 (15:38:38 CEST)
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Fri, 4 May 2018
Preprint ARTICLE Download: 106| View: 191| Comments: 0| doi:10.20944/preprints201805.0085.v1
Subject: Chemistry, Medicinal Chemistry; 7-acetamido-2-aryl-5-bromoindoles; trifluoroacetylation; cytotoxicity; apoptosis; tubulin polymerization; molecular docking
Online: 4 May 2018 (07:47:06 CEST)
Mon, 23 April 2018
Preprint ARTICLE Download: 136| View: 138| Comments: 0| doi:10.20944/preprints201804.0282.v1
Subject: Chemistry, Medicinal Chemistry; aminosteroid; aminocycloartane; alkaloid; 3D-QSAR; CoMFA; antitrypanosomal activity; cytotoxicity
Online: 23 April 2018 (11:02:16 CEST)
Thu, 5 April 2018
Preprint REVIEW Download: 142| View: 160| Comments: 0| doi:10.20944/preprints201804.0071.v1
Subject: Chemistry, Medicinal Chemistry; Sulfenic acids; Sulfoxides; Sulfones; Disulfides; Alliin derivatives; Glycoconjugates; Pyrimidine derivatives.
Online: 5 April 2018 (16:30:18 CEST)
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Mon, 19 March 2018
Preprint ARTICLE Download: 163| View: 343| Comments: 0| doi:10.20944/preprints201803.0142.v1
Subject: Chemistry, Medicinal Chemistry; chitosan; thermoresponsive hydrogel; nitric oxide; s-nitrosothiols; biocompatibility; antimicrobial; Pseudomonas aeruginosa; pluronic F127
Online: 19 March 2018 (07:25:27 CET)
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Wed, 7 March 2018
Preprint ARTICLE Download: 198| View: 408| Comments: 2| doi:10.20944/preprints201803.0050.v1
Subject: Chemistry, Medicinal Chemistry; carboxamide; carbohydrazine; antibacterial; antifungal; molecular docking; Schiff base; NMR; IR
Online: 7 March 2018 (05:11:10 CET)
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Thu, 1 March 2018
Preprint ARTICLE Download: 247| View: 222| Comments: 0| doi:10.20944/preprints201803.0003.v1
Subject: Chemistry, Medicinal Chemistry; derivatives of N-phenylanthranilic acids; anti-inflammatory activity; flexible molecular docking; microsomal prostaglandin E synthase-1
Online: 1 March 2018 (04:58:58 CET)
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Thu, 22 February 2018
Preprint ARTICLE Download: 269| View: 300| Comments: 0| doi:10.20944/preprints201802.0142.v1
Subject: Chemistry, Medicinal Chemistry; reactive selenium species; arylmethyl selenocyanate; cellular thiolstat; antimicrobial; anticancer; ESKAPE; multidrug resistance
Online: 22 February 2018 (11:34:22 CET)
Fri, 2 February 2018
Preprint ARTICLE Download: 190| View: 252| Comments: 0| doi:10.20944/preprints201802.0021.v1
Subject: Chemistry, Medicinal Chemistry; Keywords: one-pot synthesis; single crystal x-ray crystallography; oxovanadium(IV); zinc(II); spectroscopic studies; in vitro antibacterial studies.
Online: 2 February 2018 (16:00:10 CET)
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Wed, 31 January 2018
Preprint ARTICLE Download: 370| View: 307| Comments: 0| doi:10.20944/preprints201801.0292.v1
Subject: Chemistry, Medicinal Chemistry; African medicinal plants; Leishmaniasis; natural products; protozoal diseases; Schistosomiasis; Trypanosomiasis
Online: 31 January 2018 (05:28:15 CET)
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Wed, 10 January 2018
Preprint SHORT NOTE Download: 226| View: 274| Comments: 0| doi:10.20944/preprints201801.0087.v1
Subject: Chemistry, Medicinal Chemistry; redox-sensitive; disulfide linker; gemini amphiphiles; gene therapy
Online: 10 January 2018 (09:12:03 CET)
Tue, 9 January 2018
Preprint ARTICLE Download: 297| View: 337| Comments: 0| doi:10.20944/preprints201801.0079.v1
Subject: Chemistry, Medicinal Chemistry; Diabetes; GPR40; AKRB1; PPARγ; GLUT-4
Online: 9 January 2018 (08:54:18 CET)
Tue, 2 January 2018
Preprint ARTICLE Download: 264| View: 283| Comments: 0| doi:10.20944/preprints201711.0177.v2
Subject: Chemistry, Medicinal Chemistry; Leishmania; thiochroman-4-ones; acyl hydrazone; cytotoxicity
Online: 2 January 2018 (10:11:55 CET)
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Mon, 11 December 2017
Preprint ARTICLE Download: 229| View: 376| Comments: 0| doi:10.20944/preprints201712.0066.v1
Subject: Chemistry, Medicinal Chemistry; cancer; cell line; urea derivatives; synthesis; antiproliferative activity
Online: 11 December 2017 (15:10:36 CET)
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Tue, 31 October 2017
Preprint ARTICLE Download: 365| View: 308| Comments: 0| doi:10.20944/preprints201710.0200.v1
Subject: Chemistry, Medicinal Chemistry; 4-Thiazolidinones; ORAC assay; Metalloproteinase-9; Docking study; Keratinocytes cultures; Nuclear factor -kB.
Online: 31 October 2017 (16:36:16 CET)
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Preprint ARTICLE Download: 317| View: 414| Comments: 0| doi:10.20944/preprints201710.0196.v1
Subject: Chemistry, Medicinal Chemistry; osteoporosis; herbal medicine; Kukoamine B; osteoblast; osteoclast; bone mineral density; ovariectomized mice
Online: 31 October 2017 (15:35:04 CET)
Preprint ARTICLE Download: 777| View: 498| Comments: 0| doi:10.20944/preprints201710.0194.v1
Subject: Chemistry, Medicinal Chemistry; Africa; Terminalia brownii; antifungal extracts; Aspergillus, Nattrassia, Fusarium; triterpenoids; flavonoids; ellagitannins; stilbenes
Online: 31 October 2017 (09:54:35 CET)
Fri, 13 October 2017
Preprint ARTICLE Download: 297| View: 414| Comments: 0| doi:10.20944/preprints201710.0088.v1
Subject: Chemistry, Medicinal Chemistry; Caesalpinia sappan; cassane diterpenes; N bridge; antimalarial activity
Online: 13 October 2017 (06:30:04 CEST)
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Thu, 17 August 2017
Preprint ARTICLE Download: 1018| View: 1175| Comments: 0| doi:10.20944/preprints201708.0057.v1
Subject: Chemistry, Medicinal Chemistry; [18F]PSMA-1007; fluorine-18; PSMA; automation; prostate cancer; PET
Online: 17 August 2017 (06:10:57 CEST)
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Tue, 11 July 2017
Preprint REVIEW Download: 589| View: 481| Comments: 0| doi:10.20944/preprints201707.0019.v1
Subject: Chemistry, Medicinal Chemistry; affective disorders; alzheimer’s disease; l-Deprenyl (Selegiline); donepezil; galantamine; value; inhibitor constant; mechanism-based inhibition; multitarget-directed ligand (MTDL); rasagiline; rivastigmine
Online: 11 July 2017 (05:58:53 CEST)
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Fri, 30 June 2017
Preprint ARTICLE Download: 537| View: 633| Comments: 0| doi:10.20944/preprints201706.0132.v1
Subject: Chemistry, Medicinal Chemistry; arylamine N-acetyltransferases; cancer; tuberculosis; drug discovery; traditional Chinese medicine; virtual screening; molecular dynamics simulation; MM-PBSA
Online: 30 June 2017 (11:36:22 CEST)
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Preprint ARTICLE Download: 530| View: 572| Comments: 0| doi:10.20944/preprints201706.0128.v1
Subject: Chemistry, Medicinal Chemistry; steroidal dimer; steroidal N-heterocycles; antiproliferative activity; esophageal cancer cells
Online: 30 June 2017 (07:43:06 CEST)
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Fri, 16 June 2017
Preprint COMMUNICATION Download: 515| View: 572| Comments: 0| doi:10.20944/preprints201706.0074.v1
Subject: Chemistry, Medicinal Chemistry; deep-sea; actinomycete; Microbacterium sp.; indole
Online: 16 June 2017 (04:40:54 CEST)
Mon, 15 May 2017
Preprint REVIEW Download: 1278| View: 867| Comments: 0| doi:10.20944/preprints201705.0115.v1
Subject: Chemistry, Medicinal Chemistry; Palladium; Suzuki cross coupling; natural product; non-natural product
Online: 15 May 2017 (18:30:52 CEST)
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Mon, 24 April 2017
Preprint ESSAY Download: 542| View: 669| Comments: 0| doi:10.20944/preprints201704.0120.v2
Subject: Chemistry, Medicinal Chemistry; oleanolic acid derivatives; synthesis; anti-tumor activity; molecular docking; computer-aided drug design
Online: 24 April 2017 (12:08:36 CEST)
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Thu, 16 March 2017
Preprint REVIEW Download: 760| View: 830| Comments: 0| doi:10.20944/preprints201703.0118.v1
Subject: Chemistry, Medicinal Chemistry; dengue; chikungunya; virus enzymes; antiviral; natural products
Online: 16 March 2017 (09:42:52 CET)
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Fri, 10 March 2017
Preprint ARTICLE Download: 729| View: 803| Comments: 0| doi:10.20944/preprints201703.0053.v1
Subject: Chemistry, Medicinal Chemistry; 1,3,4-Thiadiazole; 1,2,4-Triazole; synthesis; MTT assay; Cytotoxicity of Schiff base
Online: 10 March 2017 (10:11:56 CET)
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Tue, 7 March 2017
Preprint ARTICLE Download: 559| View: 692| Comments: 0| doi:10.20944/preprints201703.0037.v1
Subject: Chemistry, Medicinal Chemistry; hypertension; 4-hydroxy-2-nonenal (4HNE); reactive oxygen species(ROS)
Online: 7 March 2017 (07:00:16 CET)
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Thu, 15 December 2016
Preprint ARTICLE Download: 910| View: 856| Comments: 0| doi:10.20944/preprints201612.0082.v1
Subject: Chemistry, Medicinal Chemistry; transdermal physical penetration technology; Fu’s Cupping Therapy; pharmacokinetics; SEM; TEM; stratum corneum; mechanism
Online: 15 December 2016 (10:57:46 CET)
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Sun, 27 November 2016
Preprint CASE REPORT Download: 840| View: 931| Comments: 1| doi:10.20944/preprints201611.0134.v1
Subject: Chemistry, Medicinal Chemistry; GINKGO; hyperlipideamia; lipid profile
Online: 27 November 2016 (04:43:15 CET)
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Mon, 14 November 2016
Preprint ARTICLE Download: 747| View: 786| Comments: 0| doi:10.20944/preprints201611.0072.v1
Subject: Chemistry, Medicinal Chemistry; aporphine derivatives; antiarrhythmia; 10,11-dibromocrebanine; 3-bromocrebanine; crebanine; stephanine
Online: 14 November 2016 (07:24:04 CET)
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Preprint ARTICLE Download: 1022| View: 1004| Comments: 0| doi:10.20944/preprints201611.0071.v1
Subject: Chemistry, Medicinal Chemistry; diabetes mellitus; metformin; glibenclamide and lipid profile
Online: 14 November 2016 (07:14:00 CET)
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Mon, 7 November 2016
Preprint ARTICLE Download: 616| View: 822| Comments: 0| doi:10.20944/preprints201611.0043.v1
Subject: Chemistry, Medicinal Chemistry; chalcone; cytotoxic activity; pharmacophore model
Online: 7 November 2016 (08:30:12 CET)
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Mon, 31 October 2016
Preprint ARTICLE Download: 820| View: 815| Comments: 1| doi:10.20944/preprints201610.0137.v1
Subject: Chemistry, Medicinal Chemistry; glibenclamide therapies; glycemic; Glucose-6-phosphatase
Online: 31 October 2016 (08:35:41 CET)
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Thu, 29 September 2016
Preprint ARTICLE Download: 1039| View: 1115| Comments: 0| doi:10.20944/preprints201609.0122.v1
Subject: Chemistry, Medicinal Chemistry; Cancer; FGFR; Inhibitor; 4‐Substituted‐1H‐indazole
Online: 29 September 2016 (15:42:08 CEST)
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Mon, 15 August 2016
Preprint ARTICLE Download: 1259| View: 989| Comments: 0| doi:10.20944/preprints201608.0145.v1
Subject: Chemistry, Medicinal Chemistry; methyl 3,4-dihydroxybenzoate; oxidative stress; apoptosis; neuroprotection; nuclear factor erythroid 2-related factor 2
Online: 15 August 2016 (10:42:05 CEST)
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Thu, 11 August 2016
Preprint ARTICLE Download: 1389| View: 1123| Comments: 0| doi:10.20944/preprints201608.0119.v1
Subject: Chemistry, Medicinal Chemistry; thiazoles; thiadiazoles; hydrazonoyl chlorides; anticancer activity; structure activity relationship
Online: 11 August 2016 (11:05:21 CEST)
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Tue, 9 August 2016
Preprint ARTICLE Download: 1046| View: 1010| Comments: 0| doi:10.20944/preprints201608.0086.v1
Subject: Chemistry, Medicinal Chemistry; Acid hydrolysis; Degradation product; Saikosaponin a
Online: 9 August 2016 (11:32:29 CEST)
Tue, 2 August 2016
Preprint ARTICLE Download: 1286| View: 1154| Comments: 0| doi:10.20944/preprints201608.0013.v1
Subject: Chemistry, Medicinal Chemistry; α-mangostin; antibacterial; antifungal; food packaging; semi-synthetic modification
Online: 2 August 2016 (09:02:09 CEST)
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