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Preprint ARTICLE | doi:10.20944/preprints202405.0506.v1

Upper Back Distinguishing Work-Related Musculoskeletal Problems among Quay and Rubber Tyred Gantry Crane Operators Working in Deep-Sea Port

Teerayut Sa-ngiamsak, Anamai Thetkathuek

Subject: Public, Environmental And Occupational Health, Public Health And Healthcare Keywords: port crane operators; quay crane; rubber tyred gantry crane; work-related musculoskeletal problem; perceived discomfort

Online: 8 May 2024 (14:03:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0508.v1

HCI and Data: Interacting in a New Era of Virtualization

Iván Durango Blanco, José Antonio Gallud Lázaro, Victor M. Ruiz Penichet

Subject: Information Systems, Computer Science And Mathematics Keywords: Human-Data Interaction; Human-Computer Interaction; Big Data; Data virtualization; Data Accessibility; Data Management; Data Privacy; Data Ethics; Data-Driven Decision-Making

Online: 8 May 2024 (14:01:28 CEST)

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This article explores the intricate relationship between Human-Data Interaction (HDI) and Data Virtualization (DV), two integral fields that are redefining how we engage with and manage data in the digital age. Positioned at the intersection of technology and user-centric design, this study examines how DV can transcend traditional data management boundaries to significantly enhance data accessibility, legibility, and agency, thus fostering more ethical and meaningful interactions across various sectors. Opening with a detailed exposition on the evolving role of HDI, the paper contextualizes the importance of user-centric data practices within contemporary digital challenges. HDI’s principles are pivotal as they advocate for user empowerment in data interactions, ensuring that data processes are not only transparent but also negotiable and aligned with users’ needs and ethical standards. DV emerges as a transformative solution that inherently supports these principles by integrating diverse data sources into a cohesive and accessible format, thereby eliminating many of the inefficiencies found in conventional data management systems. Through a series of nuanced case studies, the paper provides empirical evidence of DV’s effectiveness across diverse domains. In healthcare, DV facilitates a holistic approach to patient care by providing seamless access to comprehensive medical records, thereby enabling faster, more accurate diagnostic and treatment processes. In the financial sector, DV proves instrumental in enhancing the detection and management of fraud, integrating transactional data across global platforms in real-time to allow for swift, proactive interventions. In education, DV supports personalized learning by synchronizing data from various educational tools, thus allowing for tailored educational experiences that respond dynamically to student performance and engagement metrics. Moreover, the paper critically addresses the ethical considerations and privacy concerns that arise with the integration of HDI and DV, particularly as data interactions become more pervasive and complex. By proposing forward-thinking research directions, it seeks to refine these technologies to better serve societal needs while addressing potential risks and governance issues. In conclusion, this study significantly contributes to the discourse on HDI by advocating for DV as an essential, innovative tool that enhances the clarity, fairness, and efficacy of data interactions. By demonstrating how DV can transform large-scale data sets into user-friendly formats that support decision-making and improve operational efficiencies, the paper underscores DV’s potential to advance a range of industries and enhance the daily lives of individuals interacting with digital systems.

Preprint ARTICLE | doi:10.20944/preprints202405.0504.v1

Characterization of Aerosols Elementary Composition Emitted by Fires in the North of the Pantanal

Lucas Cardoso Ramos, Thais Costa Brunelli, Flávio César Vicentin, Leone Francisco Amorim Curado, André Matheus de Souza Lima, Fernando Gonçalves Morais, Rafael da Silva Palácios, Nicolas Neves de Oliveira, João Basso Marques

Subject: Atmospheric Science And Meteorology, Environmental And Earth Sciences Keywords: aerosol; AOD; EDXRF; biomass burning; black carbon

Online: 8 May 2024 (13:55:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0507.v1

Quantifying Traditional Wisdom: A Study of Indigenous Medicinal Plants in Suhelwa Wildlife Sanctuary, India

Anju K Ojha

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Ethnomedicine; Medicinal Plants; Traditional Knowledge; Biodiversity Conservation; Sustainable Healthcare; Suhelwa; Terai; India

Online: 8 May 2024 (13:47:44 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0509.v1

Evidence of Dextral Strike-Slip Movement of the Alakol Lake Fault in the Western Junggar Based on Remote Sensing

Wenxing Yi, An Li, Liangxin Xu, Zongkai Hu, Xiaolong Li

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: Alakol Lake fault; dextral strike-slip; Slip rate; UAV photogrammetry; Satellite Stereo-imagery

Online: 8 May 2024 (13:46:34 CEST)

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The NW-SE trending dextral strike-slip faults on the north side of the Tian Shan play an important role in accommodating the crustal shortening, which mainly includes the Karatau fault, Talas-Fergana fault, Dzhalair-Naiman fault, Aktas fault, Dzhungarian fault (also named Bolokenu-Aqikekuduk fault) and Chingiz fault. The classic viewpoint is that the strike-slip fault is the adjustment product caused by the difference of the crustal shortening from west to east. Another viewpoint attributes the dextral strike-slip fault to large-scale sinistral shearing. The Alakol Lake Fault is situated along the northern margin of the Dzhungarian Gate, stretching for roughly 150 km from Lake Ebinur to Lake Alakol. Our team utilized aerial photographs, Satellite Stereo-imagery, and field observation to map the distribution of the Alakol Lake fault. Our findings provided evidence supporting the assertion that the fault is a dextral strike-slip fault. In reference to its spatial distribution, Lake Alakol is situated in a pull-apart basin that lies between two major dextral strike-slip fault lines: the Chingiz and Dzhungarian faults. The Alakol Lake Fault serves as a connecting point for these two faults, resulting in the formation of a mega NW-SE dextral strike-slip fault zone. According to our analysis of the dating samples taken from the alluvial fan, as well as our measurement of the displacement of the riser and gully, it appears that the Alakol Lake fault has a dextral strike-slip rate of 0.8-1.5mm/yr. The strike-slip rate of the Alakol Lake fault is comparatively higher than that of the Chingiz fault in the northern region (~0.7 mm/yr), but slower than that of the Dzhungarian fault in the southern (3.2-5 mm/yr). The Chingiz-Alakol-Dzhungarian fault zone shows a gradual decrease in deformation towards the interior of the Kazakhstan platform. We contend that the rate of deformation observed is better explained by the crustal shortening adjustment model, rather than the large-scale sinistral shearing model.

Preprint REVIEW | doi:10.20944/preprints202405.0492.v1

Phagocytosis Checkpoints in Glioblastoma: CD47 and Beyond

Amber Afzal, Zobia Afzal, Sophia Bizink, Amanda Davis, Sara Makahleh, Yara Mohamed, Salvatore J Coniglio

Subject: Immunology And Microbiology, Biology And Life Sciences Keywords: Glioblastoma; glioma; macrophage; phagocytosis; CD47; CSF-1R; Siglec

Online: 8 May 2024 (13:44:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0444.v1

Estimation and Compensation of the Ionospheric Path Delay Phase in PALSAR-3 and NISAR-L Interferograms

Urs Wegmüller, Charles L. Werner, Othmar Frey, Christophe Magnard

Subject: Remote Sensing, Environmental And Earth Sciences Keywords: SAR; DInSAR; ionosphere; dispersive phase; non-dispersive phase; split-spectrum method; double difference interferogram; PALSAR-3; NISAR

Online: 8 May 2024 (13:42:30 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0440.v1

Techno-Economic Assessment of Anaerobic Digestion Technology for Small- and Medium-Sized Animal Husbandry Enterprises

Alexandros Eftaxias, Iliana Kolokotroni, Christos Michailidis, Panagiotis Charitidis, Vasileios Diamantis

Subject: Waste Management And Disposal, Environmental And Earth Sciences Keywords: anaerobic digestion; biogas; circular economy; manure; sustainable production; waste management; cost equations

Online: 8 May 2024 (13:36:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0432.v1

The Role of Multigene Panel Next-Generation Sequencing Techniques in Managing Patients with Metastatic Colorectal Carcinoma

Laura Matteucci, Francesco Giulio Sullo, Chiara Gallio, Luca Esposito, Margherita Muratore, Ilario Giovanni Rapposelli, Daniele Calistri, Elisabetta Petracci, Claudia Rengucci, Laura Capelli, Elisa Chiadini, Paola Ulivi, Alessandro Passardi, Alessandro Bittoni

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: metastatic colorectal cancer; multigene panel; next-generation sequencing; molecular biomarkers; druggable targets

Online: 8 May 2024 (13:34:55 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0499.v1

Combination of Hydrolysable Tannins and Zinc Oxide on Enterocyte Functionality: In Vitro Insights

Francesca Ciaramellano, Lucia Scipioni, Benedetta Belà, Giulia Pignataro, Giacomo Giacovazzo, Clotilde Beatrice Angelucci, Roberto Giacominelli Stuffler, Alessandro Gramenzi, Sergio Oddi

Subject: Other, Biology And Life Sciences Keywords: Caco-2 cells; epithelial barrier function; gastrointestinal diseases; zinc oxide (ZnO); hydrolysable tannins (HTs); epithelial barrier function; oxidative stress

Online: 8 May 2024 (13:25:09 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0498.v1

Cerebral Microbleeds Associate with Brain Endothelial Cell Activation-Dysfunction and Blood-Brain Barrier Dysfunction-Disruption with an Increased Risk of Hemorrhagic and Ischemic Stroke That Is Capable of Exacerbating Neurodegeneration

Melvin Ray Hayden

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: Alzheimers Disease; BBB; Cerebral microbleeds; Dementia; Hypertension; MRI; Neurovascular unit; cerebral small vessel disease; Transmission electron microscopy

Online: 8 May 2024 (12:47:07 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0501.v1

IGF-1 and IGFBP-1, Possible Predictors of Response to Lifestyle Intervention – Results from Randomized Controlled Trials

Nina M.T. Meyer, Stefan Kabisch, Ulrike Dambeck, Caroline Honsek, Margrit Kemper, Christiana Gerbracht, Ayman M. Arafat, Andreas L. Birkenfeld, Peter E. H. Schwarz, Jürgen Machann, Martin A. Osterhoff, Martin O. Weickert, Andreas F. H. Pfeiffer

Subject: Endocrinology And Metabolism, Medicine And Pharmacology Keywords: IGF-axis; lifestyle intervention; intervention response; prediabetes

Online: 8 May 2024 (12:45:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0496.v1

Baicalein Attenuates Myocardial Fibrosis via Directly Targeting Phosphoglycerate Mutase 1

Xunxun Wu, Ranqing Zang, Changxin Zhang, Meiyan Liu, Site Wei, Ni Yang, Siqi Wang, Yong Diao

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: DARTS; Myocardial fibrosis; PGAM1; Baicalein; Carthamus tinctorius L.

Online: 8 May 2024 (12:02:13 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0495.v1

Quantum Data Science: Leveraging Data Analytics for Advancing Quantum Computing

Koffka Khan

Subject: Computer Science, Computer Science And Mathematics Keywords: Quantum Computing; Data Science; Quantum Algorithms; Quantum Data Analysis; Quantum Error Correction

Online: 8 May 2024 (12:01:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0430.v1

Evolution of Space Exploration: A Statistical Analysis of Space Launches including Challenges and Future Outlook

REDDY VARUN VUNNAM

Subject: Space And Planetary Science, Environmental And Earth Sciences Keywords: Space Exploration; International Space Station; Space Debris; Space Tourism; Space Sustainability

Online: 8 May 2024 (11:58:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202310.1872.v6

Alena Tensor and Its Possible Applications in Unification Theories

Piotr Ogonowski, Piotr Skindzier

Subject: Theoretical Physics, Physical Sciences Keywords: unification of interactions; general relativity; quantum field theory; quantum mechanics

Online: 8 May 2024 (11:36:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0489.v1

Influence of Iterative Reconstruction Algorithm towards Transfer Function and Contrast resolution of Low Dose CT Lung Cancer Screening

Esnu Halim, Dania Mazlan, Mohd Mustafa Awang Kechik, Hanif Haspi Harun, Nor Azura Muhammad, Mohammad Johari Ibahim, Muhammad Khalis Abdul Karim

Subject: Radiation And Radiography, Physical Sciences Keywords: Computed Tomography; lung cancer screening; Iterative Reconstruction; Task-Based Assessment; Ultra-low dose; Noise Power Spectrum.

Online: 8 May 2024 (11:34:39 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0491.v1

Repurposing of Synthetic Acetaminophen Derivatives Containing Benzothiazole Scaffold as Alternative Therapy for Infectious Diarrhea Caused by Drug-Resistant Shigella Species

Boniface Pone Kamdem, Brice rostan Pinlap, Bijou-Lafortune Noumboue Kouamou, Aubin Youbi Kamche, Boris Arnaud Kuate, Joseph Tsemeugne, Orleans Ngomo, Pierre Mkounga, Fabrice Fekam Boyom

Subject: Pharmacology And Toxicology, Medicine And Pharmacology Keywords: Acetaminophen; Benzothiazoles; Azo dyes; Shigella flexneri; Anti-Shigella activity; Repositioning; Combination studies; Diarrhea.

Online: 8 May 2024 (11:33:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0493.v1

Spatio-temporal Evolution and Drivers of High-quality Utilization of Urban Land in Chinese Cities

Bing Kuang, Jinhua Liu

Subject: Geography, Planning And Development, Social Sciences Keywords: urban land use; high-quality development; spatio-temporal evolution; driving factors

Online: 8 May 2024 (11:29:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202302.0051.v71

Duality Principles and Numerical Procedures for a Large Class of Non-convex Models in the Calculus of Variations

Fabio Silva Botelho

Subject: Applied Mathematics, Computer Science And Mathematics Keywords: duality theory; non-convex analysis; numerical method for a non-smooth model

Online: 8 May 2024 (11:28:29 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0426.v1

Exploring Novel Biomarkers for an Acute Coronary Syndrome Diagnosis Utilizing Plasma Metabolomics

Masayuki Shibata, Masahiro Sugimoto, Norikazu Watanabe, Atsuo Namiki

Subject: Cardiac And Cardiovascular Systems, Medicine And Pharmacology Keywords: acute coronary syndrome; biomarker; metabolomics; multiple logistic regression model

Online: 8 May 2024 (11:25:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0474.v1

Quality Education for All: A Fuzzy Set Analysis of Sustainable Development Goal Compliance

Luísa Carvalho, Dora Almeida, Ana Loures, Paulo Ferreira, Fernando Rebola

Subject: Other, Social Sciences Keywords: Sustainable Development Goals; Quality education; Development; Fuzzy set qualitative comparative analysis; Regional analysis.

Online: 8 May 2024 (11:24:42 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0448.v1

Financial Impact of Personal Electric Transportation Platforms in an Urban Area: A Cohort of Injuries over 18 Months at a Level 1 Urban Trauma Center

Yuval Ran, Dana Niry, Genady Shendler, Itay Blum, Aviad Rabinowich, Dana Stav, Zmira Silman, Amit Benady, Jacob Chen, Adi Brenner

Subject: Health Policy And Services, Public Health And Healthcare Keywords: Financial; policy; planning; injury-prevention; cost; micro-mobility; e-bicycle; e-scooter

Online: 8 May 2024 (11:21:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0466.v1

GERD after Roux-en-Y Gastric Bypass: Prevalence and Risk Factors Analysis

Matas Pažūsis, Gabrielė Gerasimovič, Rūta Petereit, Rita Gudaitytė, Almantas Maleckas

Subject: Gastroenterology And Hepatology, Medicine And Pharmacology Keywords: bariatric surgery; Roux-en-Y gastric bypass; GERD; prevalence; risk factors

Online: 8 May 2024 (11:20:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0447.v1

Larvicidal Activity of Hemp Extracts and Cannabidiol against the Yellow Fever Mosquito Aedes aegypti

Erick J. Martínez Rodríguez, P. Larry Phelan, Luis Cañas, Nuris Acosta, Harinantenaina L. Rakotondraibe, Peter M. Piermarini

Subject: Toxicology, Biology And Life Sciences Keywords: Hemp; extracts; cannabidiol (CBD); mosquito; larvicide; insecticide resistance.

Online: 8 May 2024 (11:18:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0458.v1

Can Peripheral Vertigo Be Predicted?

Monika Kvederaitė, Maksimilian Grasevič, Antanas Vaitkus

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: peripheral vertigo; predicting peripheral vertigo; prediction; risk factors.

Online: 8 May 2024 (11:14:22 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0488.v1

Oligodendrocyte Progenitors in Glial Scar: A Bet on Remyelination

Davide Marangon, Juliana Helena Castro e Silva, Valentina Cerrato, Enrica Boda, Davide Lecca

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: remyelination; oligodendrocytes; glia; astrocytes; proteoglycans; spinal cord injury; multiple sclerosis; demyelination; CNS lesion.

Online: 8 May 2024 (10:53:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0201.v2

Predictors of Speech-in-Noise Understanding in a Population of Occupationally Noise-Exposed Individuals

Guillaume Andéol, Nihaad Paraouty, Fabrice Giraudet, Nicolas Wallaert, Vincent Isnard, Annie Moulin, Clara Suied

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: Extended high frequency; speech in noise; amplitude modulation detection; frequency modulation detection; distortion products of otoacoustic emissions; electrocochleography; speech spatial and hearing qualities questionnaire

Online: 8 May 2024 (10:35:04 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0460.v1

Macular Ischemia Changes in Patients with Diabetic Macular Edema Treated with Aflibercept and Ranibizumab

Dimitrios Maris, Anna Dastiridou, Maria Kotoula, Aikaterini Karathanou, Evangelia E. Tsironi, Alexandra Bargiota, Sofia Androudi

Subject: Ophthalmology, Medicine And Pharmacology Keywords: diabetic macular edema; ranibizumab; aflibercept; ischemia; fovea avascular zone; OCT angiography

Online: 8 May 2024 (10:35:00 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0452.v1

Identifying the Leading Sources of Saturated Fat and Added Sugar in U.S. Adults

Christopher A Taylor, Peter Madril, Rick Weiss, Cynthia A Thomson, Genevieve F Dunton, Michelle R Jospe, Kelli M Richardson, Edward J Bedrick, Susan M Schembre

Subject: Behavioral Sciences, Biology And Life Sciences Keywords: Saturated fat; added sugars; dietary assessment; dietary surveillance; dietary intakes; ecological momentary assessment

Online: 8 May 2024 (10:34:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0445.v1

Distribution and impacts of invasive plant species in Gullele Botanical Garden

Mehari Girmay, Derib Abebaw, Melese Bekele

Subject: Plant Sciences, Biology And Life Sciences Keywords: Gullele; impacts; Indigenous species; invasive plants; rehabilitation

Online: 8 May 2024 (10:34:53 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0462.v1

CT Effective Dose and Image Quality in Deep Learning Image Reconstruction in Intensive Care Patients

Emilio Quaia, Elena Kiyomi Lanza de Cristoforis, Elena Maria Agostini, Chiara Zanon

Subject: Other, Medicine And Pharmacology Keywords: CT; intensive care; reconstruction; algorithms; deep learning

Online: 8 May 2024 (10:34:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0472.v1

Demystifying Heavy Metals and Physicochemical Characteristics of Groundwater in a Volcano-Tectonic Region of Middle Awash, Ethiopia, for Multipurpose Use

Yosef Abebe, Taye Alemayehu, Behialu Birhanu, Tena Alamirew, Esayas Alemayehu

Subject: Pollution, Environmental And Earth Sciences Keywords: Awash River; groundwater; heavy metals; Lake Beseka; water quality

Online: 8 May 2024 (10:34:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0457.v1

Morphological and Genetic Assessment of Invasive Corbicula Lineages in Southern South America: A Case Study in Argentina

Leandro Andrés Hünicken, Esteban Marcelo Paolucci, Pablo Damian Lavinia, Francisco Sylvester

Subject: Ecology, Evolution, Behavior And Systematics, Biology And Life Sciences Keywords: Corbicula; Morphology; COI; Argentina; Distribution

Online: 8 May 2024 (10:34:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0455.v1

Multi-Scale Digital Pathology Patch Level Prostate Cancer Grading Using Deep Learning: Use Case Evaluation of DiagSet Dataset

Tanaya Kondejkar, Salah Mohammed Awad Al-Heejawi, Anne Breggia, Bilal Ahmad, Robert Christman, Ryan Stephen T, Saeed Amal

Subject: Pathology And Pathobiology, Medicine And Pharmacology Keywords: machine learning; prostate cancer classification; health care; histopathological images

Online: 8 May 2024 (10:34:37 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0463.v1

Strategies and Actions’ Definition for the New Territorial Government Plan of Voghera, Italy: Towards a Healthier City

Roberto De Lotto, Caterina Pietra, Matilde Sessi, Elisabetta Venco

Subject: Architecture, Building And Construction, Engineering Keywords: strategic planning; practical planning actions; healthy city; planning process

Online: 8 May 2024 (10:34:33 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0225.v2

On the Indication from Pioneer 10/11 Data of an Anomalous Acceleration

Yong Gwan Yi

Subject: Astronomy And Astrophysics, Physical Sciences Keywords: Pioneer 10/11 anomalous acceleration; Hubble's law; Mach's principle

Online: 8 May 2024 (10:34:26 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0454.v1

Creating Family-Centred Support for Children with Developmental Disabilities in Africa. Examples of Local Community Interventions

Roy McConkey, Sally Allen, Chipo Mlambo, Patricia Kambarami, Karina Martin

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: disability; preschool; children; family-centred; community-based; low income; inclusion; healthcare; education

Online: 8 May 2024 (10:34:21 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0453.v1

The Institutionalization of People with Intellectual Disabilities: A Never-Ending Story

Roy McConkey

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: Intellectual disability; institutions; ; ; medical model; rights; person-centred; quality of life

Online: 8 May 2024 (10:34:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0442.v1

Reviewing the Trends of Social Value in Construction Research in the Last Decade: A Bibliometric Review

Nana Akua Asabea Gyadu-Asiedu, Clinton Aigbavboa, Simon Ofori Ametepey

Subject: Other, Environmental And Earth Sciences Keywords: Construction Industry; Social Value; Qualitative research; Social Procurement; Social Innovation; Project management; Social Benefits

Online: 8 May 2024 (10:34:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202404.0277.v2

The Role of CyberKnife Stereotactic Radiosurgery in Recurrent Cranial Medulloblastomas across Pediatric and Adult Populations

Kelly H. Yoo, Neelan J Marianayagam, David J Park, Aroosa Zamarud, Xuejun Gu, Erqi Pollom, Scott G. Soltys, Antonio Meola, Steven D Chang

Subject: Surgery, Medicine And Pharmacology Keywords: stereotactic radiosurgery; CyberKnife radiosurgery; medulloblastoma

Online: 8 May 2024 (09:49:15 CEST)

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Background and Objectives: Medulloblastoma is the most common malignant brain tumor in children. In recent decades, the therapeutic landscape has undergone significant changes, with stereotactic radiosurgery (SRS) emerging as a promising treatment for recurrent cases. Our study provides a comprehensive analysis of the long-term efficacy and safety of SRS in recurrent medulloblastomas across both pediatric and adult patients at a single institution. Methods: We retrospectively reviewed the clinical and radiological records of patients who underwent CyberKnife SRS for recurrent cranial medulloblastomas at our institution between 1998 and 2023. Follow-up data were available for 15 medulloblastomas in 10 patients. The cohort comprised 8 pediatric patients (ages 3-18) and 2 adult patients (ages 19-75). Median age at the time of SRS was 13 years, median tumor volume accounted for 1.9 cc, median biologically equivalent dose (BED) was 126 Gy, and single-fraction equivalent dose (SFED) was 18 Gy. The SRS was administered at 75% of the median isodose line. Results: Following a median follow-up of 39 months (range: 6-78), 53.3% of the medulloblastomas progressed, 13.3% regressed, and 33.3% remained stable. The 3-year local tumor control (LTC) rate for all medulloblastomas was 65%, with lower rates observed in the adult cohort (50%) and higher rates in pediatric patients (67%). The 3-year overall survival (OS) rate was 70%, with significantly higher rates in pediatric patients (75%) compared to adult patients (50%). The 3-year progression-free survival (PFS) rate was 58.3%, with higher rates in pediatric patients (60%) compared to adult patients (50%). Two pediatric patients developed radiation-induced edema, while two adult patients experienced radiation necrosis at the latest follow-up, with both adult patients passing away. Conclusion: Our study provides a complex perspective on the efficacy and safety of CyberKnife SRS in treating recurrent cranial medulloblastomas across pediatric and adult populations. The rarity of adverse radiation events (ARE) underscores the safety profile of SRS, reinforcing its role in enhancing treatment outcomes. The intricacies of symptomatic outcomes, intertwined with factors such as age, tumor location, and prior surgeries, emphasize the need for personalized treatment approaches. Our findings underscore the imperative for ongoing research and the development of more refined treatment strategies for recurrent medulloblastomas. Given the observed disparities in treatment outcomes, a more meticulous tailoring of treatment approaches becomes crucial.

Preprint ARTICLE | doi:10.20944/preprints202405.0419.v1

Chemical Content and Cytotoxic Activity on Various Cancer Cell Lines of Chaga (Inonotus obliquus) Growing on Betula pendula and Betula pubescens

Ain Raal, Hedi Kaldmäe, Karin Kütt, Katrin Jürimaa, Maidu Silm, Uko Bleive, Alar Aluvee, Kalev Adamson, Marili Vester, Mart Erik, Oleh Koshovyi, Khan Viet Nguyen, Hoai Thi Nguyen, Rein Drenkhan

Subject: Pharmacy, Medicine And Pharmacology Keywords: Betula pendula; Betula pubescens; birch; cancer, cell lines; chaga; Estonia; glucans; Inonotus obliquus; triterpenoids

Online: 8 May 2024 (09:48:08 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0418.v1

Visual Fixation of Skull Vibration Induced Nystagmus in Patients with Peripheral Vestibulopathy

Melissa Blanco, Chiara Monopoli-Roca, Marta Álvarez de Linera-Alperi, Pablo Menéndez Fernández-Miranda, Bárbara Molina, Ángel Batuecas-Caletrío, Nicolás Pérez-Fernández

Subject: Otolaryngology, Medicine And Pharmacology Keywords: ; skull vibration induced nystagmus; visual fixation; peripheral vestibulopathy ;

Online: 8 May 2024 (09:46:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0451.v1

A Review of Wormhole Stabilization in f(R) Gravity Theories

Ramesh Radhakrishnan, Patrick M. Brown, Jacob A. Matulevich, Eric W Davis, Delaram Mirfendereski, Gerald B Cleaver

Subject: Theoretical Physics, Physical Sciences Keywords: traversable wormhole; modified gravity; extended gravity; f(R) theory; wormhole stabilization

Online: 8 May 2024 (09:44:32 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0486.v1

Effect of Using Black Soldier Fly Larvae Thermocomposted Frass as a Germination Substrate on Phytotoxicity, Germination Index, Growth, and Antioxidants Content in Kale (Brassica oleracea)

Hugo González-Lara, Benito Parra-Pacheco, Armando Gudiño-Calixto, Ana Angélica Feregrino-Perez, Juan Fernando García-Trejo

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: organic waste; spiral economy; dynamic programming; risk management; post-decision state variable

Online: 8 May 2024 (09:43:35 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0422.v1

Review of Measuring Methods of Residual Stress in Wire Arc Additive Manufacturing Products

Fakada Dabalo Gurmesa, Hirpa Gelgele Lemu, Yosef Wakjira Adugna, Mesfin Demise Harsibo

Subject: Mechanical Engineering, Engineering Keywords: residual stress; Wire Arc Additive Manufacturing; process parameters; residual stress measurement; wire arc additive manufacturing assessment

Online: 8 May 2024 (09:42:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0477.v1

Pregnancy and Luteal Responses to Embryo Reinsertion Following Embryo Flushing in Donor Mares

Rebeca Martínez-Boví, Jana T.H. Gaber, Laura Sala-Ayala, María Plaza-Dávila, Juan Cuervo-Arango

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: horse; embryo reinsertion; progesterone; endometritis; capsule fragment

Online: 8 May 2024 (09:40:05 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0482.v1

Establishment of a Suitable Diagnostic Pipeline to Ensure Sensitive Detection of African Swine Fever Virus Genome in Porcine Semen

Virginia Friedrichs, Darwin Reicks, Jeffrey J. Zimmerman, Eric A. Nelson, Carola Sauter-Louis, Martin Beer, Jane Christopher-Hennings, Sandra Blome

Subject: Virology, Biology And Life Sciences Keywords: African swine fever virus; virus diagnostics; boar semen; commercial qPCR kits; comparison; nucleic acid extraction; sensitivity; performance

Online: 8 May 2024 (09:38:35 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0424.v1

“In the Village That She Comes from, Most of the People Don’t Know Anything about Cervical Cancer”: A Health Systems Appraisal of Cervical Cancer Prevention Services in Tanzania

Melinda Chelva, Sanchit Kaushal, Nicola West, Erica Erwin, Safina Yuma, Jessica Sleeth, Khadija Yahya-Malima, Donna Shelley, Karen Yeates

Subject: Public Health And Health Services, Public Health And Healthcare Keywords: cervical cancer; knowledge; education; beliefs; health systems appraisal; tanzania

Online: 8 May 2024 (09:36:56 CEST)

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Introduction: Cervical cancer is the fourth most common cancer in women globally and the most common cancer in Tanzania, resulting in about 9772 new cases and 6695 deaths each year. Research has shown an association between low levels of risk perception and knowledge of the prevention, risks, signs, etiology, and treatment of cervical cancer and low screening uptake, as contributing to high rates of cervical cancer-related mortality. However, there is scant literature on the perspectives of a wider group of stakeholders (e.g., policymakers, healthcare providers (HCPs), and women at risk), especially those living in rural and semi-rural settings. Methods: We adapted Risso-Gill and colleagues’ framework for a Health Systems Appraisal (HSA), to identify HCPs' perspective of the extent to which health system requirements for effective cervical cancer screening, prevention, and control are in place in Tanzania. We adapted interview topic guides for cervical cancer screening using the HSA framework approach. Study participants (69 in total) were interviewed between 2014-2018 –participants included key stakeholders, HCPs, and women at risk for cervical cancer. The data was analyzed using reflexive thematic analysis methodology. Results: Seven themes emerged from our analysis of semi-structured interviews and focus groups: 1) knowledge of cervical cancer risk and the role of screening and preventive care/services (e.g., prevention, risks, signs, etiology, and treatment), 2) training and knowledge of HCPs, 3) knowledge of cervical cancer screening among women at risk, 4) beliefs about cervical cancer screening, 5) role of traditional medicine, 6) risk factors, and 7) symptoms and signs. Conclusion: It is evident that there is a low level of knowledge of cervical cancer risk and the role of screening and preventive services among stakeholders, HCPs, and women living in rural and semi-rural locations in Tanzania. There is a critical need to implement more initiatives and programs to increase the uptake of screening and related services and allow women to make more informed decisions on their health.

Preprint ARTICLE | doi:10.20944/preprints202405.0469.v1

Implementation Management of Collaborative Robots in Knowledge-Based Organizations: An Innovative and Sustainable Perspective

Aurel Mihail Țîțu, Vasile Gusan, Mihai Dragomir, Alina Bianca Pop, Ștefan Țîțu

Subject: Automotive Engineering, Engineering Keywords: collaborative robots; sustainable manufacturing; process; management; quality; manufacturing; automation

Online: 8 May 2024 (09:35:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0425.v1

Cross-Cultural Intelligent Language Learning System (CILS): Leveraging AI to Facilitate Language Learning Strategies in Cross-Cultural Communication

Yina Xia, Seong-Yoon Shin, Jong-Chan Kim

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: Cross-Cultural Communication; Artificial Intelligence in Education; Adaptive Learning Technologies; Language Learning Systems; Intercultural Competence

Online: 8 May 2024 (09:35:34 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0427.v1

RSM to Explore the Influence Mechanism of Process Configuration and Fiber Diameter in a New Multi-needle Spinneret Electrospinning

Jianmin Jiang, Xiaojie Chen, Hang Wang, Weicheng Ou, Jiayi He, Maolin Liu, Zehui Lu, Jingyi Hu, Gaofeng Zhen, Dezhi Wu

Subject: Nanotechnology, Chemistry And Materials Science Keywords: multi-needle electrospinning; spinneret; simulation; response surface method

Online: 8 May 2024 (09:34:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0467.v1

Enhancing Histopathological Image Classification Performance through Synthetic Data Generation with Generative Adversarial Networks

José L. Ruiz-Casado, Miguel A. Molina-Cabello, Rafael M. Luque-Baena

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: generative adversarial networks; data augmentation; classification; histopathological images; breast cancer

Online: 8 May 2024 (09:33:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0428.v1

Investigating the Effects of Gamification Elements on Student Motivation, Engagement, and Academic Performance in Higher Education Courses

Xiaoshang Wang, Shi Suxue, Yanfei Zheng, Charles Hackman Kwamena Essel, Michael Provide Fumey, Percy David Papa Akuetteh

Subject: Education, Social Sciences Keywords: Innovative Gamification; motivational development; online learning; psychological outcomes; user engagements

Online: 8 May 2024 (09:28:41 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0417.v1

Mutational Profiles of Cutaneous Squamous Cell Carcinomas with Different Patterns of Clinical Aggression from Head and Neck District

Maria Colombino, Giuseppe Palmieri, Manuela Rodio, Matilde Tettamanzi, Silvia Rampazzo, Raffaello Margani, Emilio Trignano, Antonio Cossu, Maria Antonietta Fedeli, Giovanni Maria Fadda, Corrado Rubino

Subject: Oncology And Oncogenics, Medicine And Pharmacology Keywords: non-melanoma skin cancer; cutaneous squamous cell carcinoma (cSCC); recurrent cSCC; next generation sequencing (NGS); mutation profile; immunogenicity

Online: 8 May 2024 (09:17:25 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0423.v1

Predictive Analytics Performance on Oil and Gas: A Significant Review

Putri Azmira R Azmi, Marina Yusoff, Mohamad Taufik Mohd Salledud-din

Subject: Artificial Intelligence And Machine Learning, Computer Science And Mathematics Keywords: classification; clustering; machine learning; oil and gas; predictive analytics

Online: 8 May 2024 (09:05:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0471.v1

Nutrient Use Efficiency and Cucumber Productivity as a Function of Nitrogen Fertilization Rate and Wood Fiber Content in the Growing Media

Rita Čepulienė, Lina Marija Butkevičienė, Vaida Steponavičienė

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: nutrient uptake; cucumber productivity; wood fiber; physicochemical properties of growing media

Online: 8 May 2024 (08:54:07 CEST)

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: Greenhouse plants are usually grown in containers filled with growing media. Peat is the main component of the growing media used in greenhouses. However, peat substrate is made from peat from drained peatlands, which is a limited resource. Wood fiber can be an alternative to use as a growing media for controlled-climate crops. The chemical properties of the growing media interact and change continuously due to the small volume of the growing media, which is limited by the vegetative container. Therefore, this study aims to gain new knowledge on the impact of nutrient changes in the microbial degradation of carbon compounds in wood fiber and mixtures with peat substrate on the content and uptake of nutrients required by plants. Cucumbers (Cucumis sativus L.) were cultivated in growing media of peat substrate and wood fiber: (1) peat substrate (PS); (2) wood fiber (WF); (3) wood fiber and peat substrate 50/50 v/v (WF/PS 50/50); (4) wood fiber and peat substrate 25/75 v/v (WF/PS 25/75). The rates of fertilization were the following: (1) conventional fertilization (CF); (2) N13; (3) N23; (4) N30. Fertilization of cucumbers with different rates of nitrogen influenced the nutrient uptake. Plants grown in WF/PS 50/50 and WF/PS 25/75 growing media had the best Cu uptake when fertilized with N23. When the plants grown in the wood fiber media and the 50/50 media were fertilized with N13, N23, and N30, the Mn content in the growing media at the end of the growing season was significantly lower than the Mn content in the media with conventional fertilization. Thus, nitrogen improved the uptake of Mn by plants grown not only in the wood fiber but also in combinations with peat substrate. Growing plants in wood fiber and fertilizing them with N13 can result in optimum uptake of micronutrients. The number and mass of cucumber fruits per plant were influenced by the amount of wood fiber in the growing media and the application of nitrogen fertilizer. The highest number of fruits and mass of fruits per plant was obtained significantly higher when cucumbers were grown on WF/PS 50/50 growing media with additional N13 fertilization.

Preprint ARTICLE | doi:10.20944/preprints202405.0464.v1

Dangling the Land as a Carrot’: The Bantustans and the Territorial Extension under the Apartheid Regime in South Africa

Chitja Twala, Ayanda Sphelele Ndlovu

Subject: History, Arts And Humanities Keywords: Bantustans; TBVC states; African National Congress; territorial extension; apartheid regime; Tomlinson Commission

Online: 8 May 2024 (08:52:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0415.v1

Artificial Intelligence and Cybersecurity: A Global Scenario

Subhadip Mandal, Swapan Kumar Patra

Subject: Safety Research, Social Sciences Keywords: artificial intelligence; machine learning; information resilience; robustness; data bias

Online: 8 May 2024 (08:52:15 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0473.v1

Temporal Alpha Power in Resting-State EEG as Neuromarker of Complex Childhood Trauma in Institutionalized Adolescents

Gabriela Mariana Marcu, Ciprian Ionuț Bacilă, Ana-Maria Zăgrean

Subject: Psychiatry And Mental Health, Social Sciences Keywords: ; neuromarkers; resting-state EEG; alpha waves; complex childhood trauma; adolescents; biomarkers; adversities ;

Online: 8 May 2024 (08:49:22 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0478.v1

Exploring the Microbial Mosaic: Insights into Composition, Diversity, and Environmental Drivers in the Pearl River Estuary Sediments

Tal Zvi-Kedem, Maya Lalzar, Jing Sun, Jiying Li, Dan Tchernov, Dalit Meron

Subject: Environmental Science, Environmental And Earth Sciences Keywords: sediment; microbiota; Pearl River estuary; microbial markers; environmental drivers

Online: 8 May 2024 (08:46:46 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0414.v1

High Rates of Honey Bee Colony Losses and Regional Variability in Ethiopia Based on the Standardised COLOSS 2023 Survey

Teweldemedhn Gebretinsae Hailu, Alem Tadesse Atsbeha, Kibebew Wakjira, Alison Gray

Subject: Insect Science, Biology And Life Sciences Keywords: colony loss; varroa; beekeeping; natural disaster; honey bee

Online: 8 May 2024 (08:46:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0465.v1

Effect of Slaughter and Drying Temperatures on Protein Hydrolysis of Black Soldier Fly Larvae Meal

Maria Rodriguez-Rodríguez, María José Sánchez-Muros, María del Carmen Vargas-García, Agnes Timea Varga, Dmitri Fabrikov, Fernando García Barroso

Subject: Insect Science, Biology And Life Sciences Keywords: insect processing; insect meal; digestibility; hydrolysis degree; Hermetia illucens

Online: 8 May 2024 (08:43:58 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0475.v1

Aerodynamic Hinge Moment Characteristics of Pitch Regulated Mechanism for Mars Rotorcraft: Investigation and Experiments

Qingkai Meng, Yu Hu, Wei Wei, Zhaopu Yao, Zhifang Ke, Haitao Zhang, Molei Zhao, Qingdong Yan

Subject: Mechanical Engineering, Engineering Keywords: aerodynamic hinge moment; pitch angle; pitch regulated mechanism; blade pressure; flow field characteristics; Mars rotorcraft

Online: 8 May 2024 (08:26:06 CEST)

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The precise regulation of hinge moment and pitch angle driven by the pitch regulated mechanism is crucial for modulating thrust requirements and ensuring stable attitude control in Martian coaxial rotorcraft. Nonetheless, the aerodynamic hinge moment in rotorcraft presents time-dependent dynamic properties, posing significant challenges for accurate measurement and assessment for such characteristics. In this study, we delve into the detailed aerodynamic hinge moment characteristics associated with the pitch regulated mechanism of Mars rotorcraft under a spectrum of control strategies. A robust computational fluid dynamics model has been developed to simulate rotor’s aerodynamic loads, accompanied by a quantitative hinge moment characterization that takes into account the effects of varying rotor speeds and pitch angles. Our investigation has yielded a thorough understanding of the interplay between aerodynamic load behavior and rotor surface pressure distributions, leading to the creation of an empirical mapping model for hinge moments. To validate our findings, we engineered a specialized test apparatus capable of measuring the hinge moments of the pitch regulated mechanism, facilitating empirical assessments under replicated atmospheric conditions of both Earth and Mars. The result indicates aerodynamic hinge moments depend non-linearly on rotational speed, peaking at a 0° pitch angle and showing minimal sensitivity to pitch under 0°. Above 0°, hinge moments decrease, reaching a minimum at 15° before rising again. Simulation and experimental comparisons demonstrate that under Earth conditions, the aerodynamic performance and hinge moment errors are within 8.54% and 24.90%, respectively. For Mars conditions, errors remain below 11.62%, proving the CFD model’s reliability. This supports its application in the design and optimization of Mars rotorcraft systems, enhancing their flight control through accurate prediction of aerodynamic hinge moments across various pitch angles and speeds.

Preprint ARTICLE | doi:10.20944/preprints202405.0461.v1

RDAGAN:A Residual Dense Attention GAN for Microscopic Image Super-Resolution

Sanya Liu, Xiao Weng, Xingen Gao, Xiaoxin Xu, Lin Zhou

Subject: Telecommunications, Engineering Keywords: single image super-resolution; microscopic image; generative adversarial network; image processing

Online: 8 May 2024 (08:19:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0485.v1

A Novel Landmark-Based Semi-Supervised Deep Learning Method for Aneurysm Detection Using 3D TOF-MRA

Hyeonsik Yang, Eunyoung Regina Kim, ZunHyan Rieu, Donghyeon Kim, Beomseok Sohn, Minho Lee

Subject: Radiation And Radiography, Physical Sciences Keywords: neuroradiology; MRI; deep learning; aneurysm detection; semi-supervised learning; neuroradiology brain; MR; computer applications-detection; diagnosis; aneurysms

Online: 8 May 2024 (08:15:49 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0483.v1

Hepatitis B Virus Prevalence Among HIV-Uninfected People Living in Rural and Peri-Urban Areas in Botswana

Motswedi Anderson, Thabo Mangogola, Bonolo B. Phinius, Gorata Mpebe, Christopher O. Aimakhu, Wonderful T. Choga, Basetsana Phakedi, Lynnette N. Bhebhe, Doreen Ditshwanelo, Kabo Baruti, Linda Mpofu-Dobo, Lebogang Othusitse, Tsholofelo Ratsoma, Tendani Gaolathe, Joseph Makhema, Roger Shapiro, Shahin Lockman, Sikhulile Moyo, Simani Gaseitsiwe

Subject: Virology, Biology And Life Sciences Keywords: Hepatitis B Virus, HBV, prevalence, genotypes, mutations, HIV negative, Africa

Online: 8 May 2024 (07:19:03 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0443.v1

An Enhanced FGI-GSRx Software-Defined Receiver for the Execution of Long Datasets

Muwahida Liaquat, M. Zahidul H. Bhuiyan, Saiful Islam, Into Pääkkönen, Sanna Kaasalainen

Subject: Aerospace Engineering, Engineering Keywords: Software-defined GNSS receiver; open-source software; parallel processing

Online: 8 May 2024 (04:01:06 CEST)

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The Global Navigation Satellite Systems (GNSS) software-defined receivers offer greater flexibility, cost-effectiveness, customization, and integration capabilities compared to traditional hardware-based receivers, making them essential for a wide range of applications. The continuous evolution of GNSS research and the availability of new features require these software-defined receivers to upgrade continuously to facilitate the latest requirements. The Finnish Geospatial Research Institute (FGI) has been supporting the GNSS research community with its open-source implementations, such as a MATLAB-based GNSS software-defined receiver ’FGI-GSRx’ and a Python-based implementation ’FGI-OSNMA’ for utilizing Galileo’s Open Service Navigation Message Authentication (OSNMA). In this context, longer datasets are crucial for GNSS software-defined receivers to support adaptation, optimization and facilitate testing to investigate and develop future-proof receiver capabilities. In this paper we present an updated version of FGI-GSRx, namely FGI-GSRx-v2.0.0, which is also available as an open-source resource for the research community. FGI-GSRx-v2.0.0 offers improved performance as compared to its previous version, especially for the execution of long datasets. This is carried out by optimizing the receiver’s functionality and offering a newly added parallel processing feature to ensure faster capabilities to process the raw GNSS data. This paper also presents an analysis of some key design aspects of previous and current versions of FGI-GSRx for a better insight into the receiver’s functionalities. The results show that FGI-GSRx-v2.0.0 offers about 40% run time execution improvement over FGI-GSRx-v1.0.0 in case of sequential processing mode and about 59% improvement in case of parallel processing mode with 17 GNSS satellites from GPS and Galileo. In addition, an attempt is made to execute v2.0.0 with MATLAB’s own parallel computing toolbox. A detail performance comparison reveals an improvement of about 43% in execution time over v2.0.0 parallel processing mode for the same GNSS scenario.

Preprint ARTICLE | doi:10.20944/preprints202405.0372.v1

Cross-Cultural Adaptation and Validation of an Attitude about Euthanasia Scale in Portuguese Older Adults with Mixed Anxiety-Depressive Disorder

Luis Fonseca, Luísa Castro, Andreia Gonçalves, Francesco Monteleone, Guilhermina Rêgo, Rui Nunes

Subject: Psychiatry And Mental Health, Social Sciences Keywords: Euthanasia; Depression; Anxiety; Psychometrics; Scale; Older adults

Online: 8 May 2024 (03:12:28 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0380.v1

The Investigation of the Synthesis, Characterization, Molecular Docking, and Pharmacokinetic Properties of New Thiocarbohydrazones Based on Schiff Bases

Nalan Turkoz Karakullukcu

Subject: Pharmacy, Medicine And Pharmacology Keywords: thiocarbohydrazones; Schiff base; moleculer docking; urease inhibition; pharmacokinetic properties; drug combinations ;

Online: 8 May 2024 (02:40:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0420.v1

Reservoir Routing and Its Application to Atmospheric Carbon Dioxide Balance

Demetris Koutsoyiannis

Subject: Water Science And Technology, Environmental And Earth Sciences Keywords: mass balance; continuity equation; reservoir routing; residence time; response time; carbon dioxide

Online: 8 May 2024 (00:24:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0412.v1

Temporal Assessment of Phosphorus Speciation in a Model Ramsar Lake System in Asia

Anjali Venukumar, Abdugani Azimov, Gani Iztleuov, Vishnu Moorchilot, Usha K Aravind, Marat Sataev, Valsamma Koshy, Charuvila T. Aravindakumar

Subject: Environmental Science, Environmental And Earth Sciences Keywords: Vembanad lake; adjoining rivers; eutrophication; phosphorus speciation; inorganic and organic phosphorus.

Online: 7 May 2024 (23:51:36 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0405.v1

Conditional Knockout of Neurexins Alters the Contribution of Calcium Channel Subtypes to Presynaptic Ca2+-Influx

Johannes Brockhaus, Iris Kahl, Mohiuddin Ahmad, Daniele Repetto, Carsten Reissner, Markus Missler

Subject: Neuroscience And Neurology, Biology And Life Sciences Keywords: Neurexin; Calcium Channel Subtypes; Presynapse; Endocannabinoid System; Genetically Encoded Calcium Indicator

Online: 7 May 2024 (23:49:57 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0406.v1

Quantitative-Qualitative Assessment of Dream Reports in Schizophrenia and Their Correlations with Illness Severity

Gianluca Ficca, Oreste De Rosa, Davide Giangrande, Tommaso Mazzei, Salvatore Marzolo, Benedetta Albinni, Alessia Coppola, Alessio Lustro, Francesca Conte

Subject: Cognitive Science, Social Sciences Keywords: Dreams; Schizophrenia; Emotion Regulation

Online: 7 May 2024 (23:48:18 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0410.v1

Camel Milk Processing Opportunities: A Review

Arman Issimov

Subject: Food Science And Technology, Biology And Life Sciences Keywords: camel milk; dairy products; powder milk; processing opportunities

Online: 7 May 2024 (23:46:11 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.0403.v1

Simultaneous Laparoscopic Surgery for Esophageal Achalasia Combined with Epiphrenic Diverticulum: A Case Report

Koichi Okamoto, Jun Kinoshita, Hiroto Saito, Itasu Ninomiya, Noriyuki Inaki, Hiroyuki Takamura

Subject: Gastroenterology And Hepatology, Medicine And Pharmacology Keywords: achalasia; epiphrenic diverticulum; laparoscopic surgery

Online: 7 May 2024 (23:44:25 CEST)

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Preprint COMMUNICATION | doi:10.20944/preprints202403.0942.v2

Environmental Surveillance through Machine Learning-Empowered Utilization of Optical Networks

Hasan Awad, Fehmida Usmani, Emanuele Virgillito, Rudi Bratovich, Roberto Proietti, Stefano Straullu, Francesco Aquilino, Rosanna Pastorelli, Vittorio Curri

Subject: Environmental Science, Environmental And Earth Sciences Keywords: Earthquakes; Polarization; Machine-learning; Early-warnings; Optical-Networks; Sensing; Waveplate-model

Online: 7 May 2024 (17:32:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0354.v1

Design and Implementation of an Energy Selector for Laser-Accelerated Protons

Alicia Reija, David Esteban, Aarón Alejo, Jon Imanol Apiñaniz, Adrián Bembibre, José Benlliure, Michael Ehret, Javier García López, María Carmen Jiménez-Ramos, Jessica Juan-Morales, Cruz Méndez, David Pascual, María Dolores Rodríguez-Frías, Mauricio Rodríguez Ramos, And Michael Seimetz

Subject: Applied Physics, Physical Sciences Keywords: laser-plasma acceleration; proton; mono-energetic beam; magnetic dipole

Online: 7 May 2024 (17:22:50 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0340.v1

Development and Implementation of a Smart Charging System for Electric Vehicles based on the ISO 15118 Standard

Jóni Buchinho Santos, André Mendes Botelho Francisco, Cristiano Lourenço Cabrita, Janio Monteiro, André Pacheco, Pedro Jorge Sequeira Cardoso

Subject: Electrical And Electronic Engineering, Engineering Keywords: Electric Vehicles; Smart Charging; Demand Response; ISO 15118; Smart Grids; Renewable Energy Sources

Online: 7 May 2024 (17:20:56 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0325.v1

Navigating the Path to Management: Insights into Sport Manager Selection and Diversity Strategies in Romania

Valentina Stefanica, Marko Joksimović, Halil İbrahim Ceylan, Raul- Ioan Muntean

Subject: Human Resources And Organizations, Business, Economics And Management Keywords: affirmative action; recruitment strategies; decision making; board selection; organizational culture

Online: 7 May 2024 (17:15:14 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0324.v1

Better Implementation of the Rural Revitalization Strategy: China’s Land Transfer and Farmers’ Income

Qin Zhang, Yanfang Huo, Yan Han, Tianque Cao, Zifang Chen

Subject: Area Studies, Social Sciences Keywords: land transfer; farmer income; heterogeneity in farmer types; heterogeneity in income types; rural revitalization

Online: 7 May 2024 (17:14:07 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0322.v1

A Review of Data Mining Strategies by Data Type, with a Focus on Construction Processes and Health and Safety Management

Antonella Pireddu, Angelico Bedini, Mara Lombardi, Angelo L.C. Ciribini, Davide Berardi

Subject: Civil Engineering, Engineering Keywords: Clustering; Principal Component Analysis (PCA); Meta-Analysis; Construction Industry; Data Mining; Machine Learning; Prediction Models; Workplaces Safety; Smart Technology (ST); State-of-the-art

Online: 7 May 2024 (17:12:23 CEST)

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Increasingly, information technology facilitates the storage and management of data useful for risk analysis and event prediction. Studies on data extraction related to occupational health and safety are increasingly available; however, due to its variability, the construction sector warrants special attention. This review is conducted under the research programmes of the National Institute for Occupational Accident Insurance (Inail). Objectives: The research question focuses on identifying which data mining (DM) methods, among supervised, unsupervised, and others, are most appropriate to be applied to certain investigation objectives, types, and sources of data, as defined by the authors. Methods: Scopus and ProQuest were the main sources from which we extracted studies in the field of construction, published between 2014 and 2023. The eligibility criteria applied in the selection of studies, were based on the Preferred Reporting Items for Systematic Review and meta-analysis (PRISMA). For exploratory purposes, we applied hierarchical clustering, while for in-depth analysis, we use principal component analysis (PCA) and meta-analysis. Results: The search strategy based on the PRISMA eligibility criteria, provided us with 61 out of 2,234 potential articles, 202 observation, 91 methodologies, 4 survey purposes, 3 data sources, 7 data types, and 3 resource type. Cluster analysis and PCA organized the information included in the paper dataset into two dimensions and labels: "supervised methods, institutional dataset, and predictive and classificatory purposes" (correlation 0.97÷8.18E-01; p-value 7.67E-55÷1.28E-22) and the second, Dim2 "not-supervised methods; project, simulation, literature, text data; monitoring, decision-making processes; machinery and environment" (corr. 0.84÷0.47; p-value 5.79E-25÷3.59E-06). We answered the research question regarding which method, among supervised, unsupervised, or other, is most suitable for application to data in the construction industry. Conclusions: The meta-analysis provided an overall estimate of the better effectiveness of supervised methods (Odds Ratio = 0.71, Confidence Interval 0.53÷0.96) compared to not-supervised methods.

Preprint ARTICLE | doi:10.20944/preprints202405.0338.v1

Preliminary Report of Nationwide COVID-19 Vaccine Compensation in Taiwan

Yi-An Lu, Fu-Yuan Huang, Hsin Chi, Chien-Yu Lin, Nan-Chang Chiu

Subject: Primary Health Care, Public Health And Healthcare Keywords: coronavirus disease 2019 vaccine; vaccine adverse events; vaccine injury compensation program

Online: 7 May 2024 (17:06:34 CEST)

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Preprint REVIEW | doi:10.20944/preprints202401.1803.v2

Exploring Integrated Biogas Solutions for Industrial Processes: an Advanced Approach Towards Renewable Energy

Nnadikwe Johnson, AKUJURU KELVIN, JAMES RICHARD V.

Subject: Energy And Fuel Technology, Engineering Keywords: Biogas; Landfills; CO₂; H₂; H₂0; Energy Sustainability; Synthesis gas; Methane; Carbon (IV) oxide; Feedstock Gasification

Online: 7 May 2024 (17:02:30 CEST)

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This case study focuses on exploring the potential of biogas as a direct substitute for conventional fossil fuels in industrial applications. Instead of being limited to its common uses as a vehicle fuel or for power generation, this research aims to investigate how biogas can be integrated into industrial processes as an advanced and sustainable energy solution. By conducting a detailed analysis of the financial implications associated with the utilization of landfill gas and gas derived from biomass, a comprehensive understanding of their practical applications in the industrial sector can be obtained. This research goes beyond a superficial examination and delves into the intricate aspects of incorporating biogas as a viable alternative fuel source. When we say that utilizing biogas is technically feasible, it means that the necessary infrastructure and technologies are available to support its integration into industrial processes. This implies that there are existing methods and systems in place that can efficiently harness and utilize biogas for various industrial applications. These technologies ensure a seamless transition from conventional fossil fuels to renewable energy sources, leading to a more sustainable and environmentally friendly industrial landscape. Moreover, the statement that utilizing biogas is economically feasible emphasizes that the financial viability of employing biogas in industrial processes is advantageous. This research explores the potential cost savings and benefits associated with substituting conventional fuels with biogas. By carefully examining the economic aspects, such as initial investments, operational costs, and potential revenue streams, a comprehensive understanding of the financial impact of adopting biogas solutions in the industrial sector can be gained. By expanding and broadening the understanding of the technical and economic feasibility of biogas integration, this research aims to provide valuable insights into the potential of advanced biogas solutions for industrial applications. Indeed, to make biogas a viable and sustainable option as a raw material, it is necessary to establish farming subsidies and financial support specifically tailored for biogas production, similar to the existing support provided for food production. These subsidies and financial incentives play a crucial role in promoting and encouraging the growth of the biogas industry. By establishing such support systems, farmers and other stakeholders in the agricultural sector can be incentivized to participate in the production of biogas. This can involve the utilization of agricultural waste, organic residues, or dedicated energy crops for biogas generation. The financial assistance can help offset the initial investment costs, provide incentives for production, and ensure the economic viability of biogas projects. Moreover, when considering large-scale landfills or situations where industrial demands for energy are relatively low, landfill gas becomes a viable and practical option. Landfill gas, which is generated by the decomposition of organic waste in landfills, can be harnessed and utilized for various industrial purposes. This not only helps in managing waste but also provides a valuable source of renewable energy. In summary, while farming subsidies and financial support are crucial for promoting biogas production, landfill gas remains a viable option for large landfills or situations with minor industrial demands. The combination of these two approaches offers a comprehensive outlook on utilizing biogas as a renewable energy source for industrial applications.

Preprint ARTICLE | doi:10.20944/preprints202405.0421.v1

Assessing Industrial Past and Cultural Change over Industrial Lands along Hangzhou Section of Chinese Grand Canal

Furan CAO, Bin Zhu, Lingyan Huang, Chao Liu

Subject: Urban Studies And Planning, Social Sciences Keywords: Industrial Lands; Chinese Grand Canal; Cultural Change; Industrial Heritage

Online: 7 May 2024 (16:54:41 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0328.v1

Enzyme Is the Name – Adapter Is the Game

Michael Huber, Tilman Brummer

Subject: Biochemistry And Molecular Biology, Biology And Life Sciences Keywords: protein complexes; pseudokinase; KSR1; dimerization; ErbB3/HER3; immunodeficiency; SHP2; cancer; inflammatory diseases

Online: 7 May 2024 (16:52:40 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0327.v1

Chemical Compositions and Fumigation Effects of Essential Oils Derived from Cardamom, Elettaria cardamomum (L.) Maton, and Galangal, Alpinia galanga (L.) Willd Against Red Flour Beetle, Tribolium castaneum (Herbst) (Coleoptera: Tenebrionidae)

Ruchuon Wanna, Parinda Khaengkhan, Hakan Bozdoğan

Subject: Insect Science, Biology And Life Sciences Keywords: Zingiberaceae; essential oil; stored insect pest; plant secondary metabolite; GC-MS

Online: 7 May 2024 (16:50:06 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0402.v1

Wheat Yield Estimation Using Machine Learning Method Based on UAV Remote Sensing Data

Shurong Yang, Lei Li, Shuaipeng Fei, Mengjiao Yang, Zhiqiang Tao, Yaxiong Meng, Yonggui Xiao

Subject: Agricultural Science And Agronomy, Biology And Life Sciences Keywords: Machine learning; Yield prediction; Data fusion; Wheat; Phenotyping

Online: 7 May 2024 (16:47:22 CEST)

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Accurate forecasting of crop yields holds paramount importance in guiding decision-making processes related to breeding efforts. This study focused on the application of multi-sensor data fusion and machine learning algorithms based on unmanned aerial vehicles (UAVs) in wheat yield prediction. Five machine learning (ML) algorithms namely random forest (RF), partial least squares (PLS), ridge regression (RR), K-Nearest Neighbor (KNN) and eXtreme Gradient Boosting Decision Tree (XGboost) were utilized for multi-sensor data fusion, and three ensemble methods including the second-level ensemble methods (stacking and feature-weighted) and the third-level ensemble method (simple average) for wheat yield prediction. The 270 wheat hybrids were used as planting materials under full and limited irrigation treatments. A cost-effective multi-sensor UAV platform, equipped with red–green–blue (RGB), multispectral (MS), and thermal infrared (TIR) sensors, was utilized to gather remote sensing data. The results revealed that the XGboost algorithm exhibited outstanding performance in multi-sensor data fusion, with the RGB+MS+Texture+TIR combination demonstrating the highest fusion performance (R2=0.660, RMSE= 0.754). Compared with the single ML model, the employment of three ensemble methods significantly enhanced the prediction accuracy of wheat yield. Notably, the third-layer simple average ensemble method demonstrated superior performance (R2 = 0.733, RMSE= 0.668 t ha-1). It significantly outperformed both the second-layer ensemble methods of Stacking (R2= 0.668, RMSE= 0.673 t ha-1) and feature-weighted (R2= 0.667, RMSE= 0.674 t ha-1), thereby exhibiting superior predictive capabilities. This finding demonstrated that the third-layer ensemble method not only augments the predictive ability of the model but also fine-tuned the accuracy of wheat yield prediction through the employment of simple average ensemble learning. Consequently, it offers a novel perspective for crop yield prediction and breeding selection.

Preprint REVIEW | doi:10.20944/preprints202405.0326.v1

3-Chymotrypsin-like Protease (3CLpro): Validation as a Molecular Target, Proposal of a Novel Catalytic Mechanism, and Inhibitors in Preclinical and Clinical Trials

Vitor Martins de Freitas Amorim, Eduardo Pereira Soares, Anielle Salviano de Almeida Ferrari, Davi Gabriel Salustiano Merigh, Robson Francisco de Souza, Cristiane Rodrigues Guzzo, Anacleto Silva de Souza

Subject: Pharmacology And Toxicology, Medicine And Pharmacology Keywords: SARS-CoV-2; 3CLpro; Novel Mechanism of Catalysis; FDA-approved drugs; Triad

Online: 7 May 2024 (16:44:24 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0323.v1

Environmental Impact Evaluation of CO₂ Absorption and Desorption Enhancement by Membrane Gas Absorption: A life Cycle Assessment Study

Fuzhao Li, Yuexia Lv, Jinpeng Bi, Hui Zhang, Wei Zhao, Yancai Su, Tingting Du, Junkun Mu

Subject: Environmental Science, Environmental And Earth Sciences Keywords: CO₂ capture; membrane gas absorption; life cycle assessment; environmental impact

Online: 7 May 2024 (16:40:21 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0321.v1

MRI-Based Brain Tumor Classification Using Dilated Parallel Deep Convolutional Neural Network with Ensemble of Machine Learning Classifiers

Takowa Rahman, Md. Saiful Islam, Jia Uddin

Subject: Bioengineering, Engineering Keywords: Brain tumor classification; data augmentation; receptive field; grid effect; multiscale dilated parallel convolution; machine learning classifiers

Online: 7 May 2024 (16:38:48 CEST)

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Preprint CASE REPORT | doi:10.20944/preprints202405.0320.v1

Splenic Myelolipomas in the Domestic Cat – to Operate or Not to Operate?

Diana J Kennedy, Helena MT Ferreira, Melanie J Dobromylskyj, Stefan Hobi, Angel Almendros, Paweł M Bęczkowski

Subject: Animal Science, Veterinary Science And Zoology, Biology And Life Sciences Keywords: myelolipoma; spleen; splenectomy; mass; hyporexia; weight loss; cat; feline

Online: 7 May 2024 (16:31:25 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0319.v1

Factors Influencing Non-Surgical Root Canal Treatment Outcomes in Mandibular Second Molars: A Retrospective Cone-Beam Computed Tomography Analysis

Da-min Park, Woo-Hyun Seok, Ji-Young Yoon

Subject: Dentistry And Oral Surgery, Medicine And Pharmacology Keywords: non-surgical endodontics; periapical diseases; cone-beam computed tomography; treatment outcomes

Online: 7 May 2024 (16:28:45 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0413.v1

Insect Protein as a Component of Meat Analogue Burger

Anna Krawczyk, Juana Fernández-López, Anna Zimoch-Korzycka

Subject: Food Science And Technology, Biology And Life Sciences Keywords: edible insect; Alphitobius diaperinus; alternative protein source; consumer acceptance; quality properties; texture profile

Online: 7 May 2024 (15:55:12 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0416.v1

New Sustainable Fintech Business Models Created by Open API Technology: A Case Study of Korea’s Open Banking API Platform

Sangseung Oh, Gyongchan Chung, Keuntae Cho

Subject: Business And Management, Business, Economics And Management Keywords: open banking; open API; fintech; financial innovation; financial platform; payment infrastructure; business model innovation

Online: 7 May 2024 (15:44:11 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0390.v1

BSA Binding and Aggregate Formation of a Synthetic Amino Acid with Potential for Promoting Fibroblast Proliferation: An In Silico, CD Spectroscopic, DLS, and Cellular Study

Hayarpi M Simonyan, Rosanna Palumbo, Satenik Petrosyan, Anna F Mkrtchyan, Armen Galstyan, Ashot S. Saghyan, Pasqualina Liana Scognamiglio, Caterina Vicidomini, Marta Fik-Jaskółka, Giovanni N Roviello

Subject: Applied Chemistry, Chemistry And Materials Science Keywords: in silico; protein binding; self-assembling system; synthetic amino acid; fibroblast growth enhancement; tissue regeneration

Online: 7 May 2024 (15:41:49 CEST)

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This study presents the chemical synthesis, purification, and characterization of a novel non-natural synthetic amino acid. The compound was synthesized in solution, purified, and characterized using NMR spectroscopy, polarimetry, and melting point determination. Dynamic Light 22 Scattering (DLS) analysis demonstrated its ability to form aggregates with an average size of 391 nm, extending to low micrometric sizes. Furthermore, cellular biological assays revealed its ability to enhance fibroblast cell growth, highlighting its potential for tissue regenerative applications. Circular dichroism (CD) spectroscopy showed the ability of the synthetic amino acid to bind serum albumins (using bovine serum albumin (BSA) as a model), and CD deconvolution provided insights into the changes in secondary structures of BSA upon interaction with the amino acid ligand. Additionally, molecular docking using HDOCK software elucidated the most likely binding mode of the ligand inside the BSA structure. We also performed in silico oligomerization of the synthetic compound in order to obtain a model of aggregate to investigate computationally. More in detail, in the dimer formation achieved by molecular self-docking, two distinct poses were observed, corresponding to the lowest and comparable energies, with one pose exhibiting a quasi-coplanar arrangement characterized by a close alignment of two aromatic rings from the synthetic amino acids within the dimer, suggesting the presence of π-π stacking interactions. In contrast, the second pose displayed a non-coplanar configuration, with the aromatic rings oriented in a staggered arrangement, indicating distinct modes of interaction. Both poses were further utilized in the self-docking procedure. Notably, iterative molecular docking of amino acid structures resulted in the formation of higher-order aggregates, with a model of a 512-mer aggregate obtained through self-docking procedures. This model of aggregate presented a cavity capable of hosting therapeutic cargoes and biomolecules, rendering it a potential scaffold for cell adhesion and growth in tissue regenerative applications. Overall, our findings highlight the potential of this synthetic amino acid for tissue regenerative therapeutics and provide valuable insights into its molecular interactions and aggregation behavior.

Preprint ARTICLE | doi:10.20944/preprints202405.0392.v1

Efficacy of Lasmiditan as a Secondary Treatment for Migraine Attacks After Unsuccessful Treatment with a Triptan

Yasushi Shibata, Hiroshige Sato, Akiko Sato, Youichi Ha

Subject: Neuroscience And Neurology, Medicine And Pharmacology Keywords: migraine; triptan; lasmiditan; step care

Online: 7 May 2024 (15:40:27 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0391.v1

Comparative Review of Thermal Management System for BESS

Nixon Kerwa Mdachi, Chang Choong-koo

Subject: Energy And Fuel Technology, Engineering Keywords: active liquid cooling; battery energy storage systems; hybrid systems; passive cooling; thermal management systems; virtual power plants

Online: 7 May 2024 (15:39:02 CEST)

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Preprint REVIEW | doi:10.20944/preprints202405.0385.v1

Statistical Considerations for the Design and Analysis of Pragmatic Trialsin Aging Research

Ashuin Kammar-García, Liliana Aline Fernández-Urrutia, Jorge Alberto Guevara-Díaz, Javier Mancilla-Galindo

Subject: Aging, Biology And Life Sciences Keywords: pragmatic clinical trials; aged; statistical analysis; geroscience; sample size; secondary data analysis

Online: 7 May 2024 (15:36:52 CEST)

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Preprint ARTICLE | doi:10.20944/preprints202405.0404.v1

Extracts from Artemisia annua Linne’ Regulate the Translocation of p53 to Mitochondria and Induce Apoptotic Effects on LS174T Colon Cancer Cells In Vitro and In Vivo

Gaewon Nam, Bo-Min Kim, Young-Min Kim

Subject: Medicine And Pharmacology, Medicine And Pharmacology Keywords: LS174T; mitochondrial apoptosis; Artemisia annua; p53 translocation

Online: 7 May 2024 (15:35:03 CEST)

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